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Дисертації з теми "Translationally controlled tumour protein"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 31 липня 2025

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1

Thaw, Paul. "Structural studies of p23'f'y'p : a translationally controlled tumour protein." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341815.

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2

Foster, William Swinburne. "Translationally Controlled Tumour Protein as a Novel Therapeutic Target in Pulmonary Arterial Hypertension." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35006.

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Background: Pulmonary arterial hypertension (PAH) is a multifaceted disease characterized by elevated pulmonary arterial pressure, right ventricular hypertrophy, and a poor prognosis. Pathological hallmarks of PAH include pulmonary vascular remodelling, pre-capillary arterial obliteration, and plexiform lesions. Over the past 15 years, pulmonary endothelial cell (EC) apoptosis has been repeatedly implicated as a key trigger of occlusive arterial remodelling in PAH. While it has been hypothesized that pulmonary EC apoptosis gives rise to the emergence of growth-dysregulated, apoptosis- resistan

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3

Hayward, K. L. "Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival". Thesis, University of the West of England, Bristol, 2014. http://eprints.uwe.ac.uk/22538/.

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Introduction: Diabetes affects more than 346 million individuals worldwide. Some 90% of diabetics have type 2 diabetes mellitus, which is frequently associated with obesity and hyperlipidemia as well as hyperglycaemia. There is ample evidence that fatty acids become toxic (lipotoxicity) when present at elevated concentrations for prolonged periods of time, although mechanisms are still not fully elucidated. Current diabetic medications do not tackle the underlying issue of β-cell death. New therapeutic strategies to more effectively combat and early deterioration of the β-cell mass and functio

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4

Bruckner, Fernanda Prieto. "The translationally controlled tumor protein is necessary for potyvirus replication." Universidade Federal de Viçosa, 2016. http://www.locus.ufv.br/handle/123456789/11715.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2017-09-13T16:56:22Z No. of bitstreams: 1 texto completo.pdf: 2092738 bytes, checksum: 991c21e0ecefbc7be1990a39f757c9bb (MD5)<br>Made available in DSpace on 2017-09-13T16:56:22Z (GMT). No. of bitstreams: 1 texto completo.pdf: 2092738 bytes, checksum: 991c21e0ecefbc7be1990a39f757c9bb (MD5) Previous issue date: 2016-11-21<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Translationally controlled tumor protein (TCTP) é uma proteína amplamente distribuída em eucariotos. Ela está envolvida na regulação de proce

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5

陳漢文 and Hon-man Chan. "Overexpression of translationally controlled tumor protein (TCTP) predisposes to hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193056.

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Hepatocellular carcinoma (HCC) is the most common tumors worldwide. In contrast to other cancers, the prognosis of HCC is extremely poor, with less that 5% of 5-year survival rate worldwide. From our previous studies, we isolated Chromodomain Helicases/ATPase DNA binding protein1-Like (CHD1L) gene from chromosome 1q21, and characterized it as a specific oncogene in HCC. By using 2D-PAGE and MALDI-TOF mass spectrometry approach, Translationally Controlled Tumor Protein (TCTP) was identified as a CHD1L target, which was preferentially expressed in CHD1L-transfected cells. TCTP is a highly conser

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6

Karafin, Teele. "Etude de la fonction de Translationally Controlled Tumor Protein (TCTP) dans différents modèles génétiques dans la souris." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS211.

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TCTP est une protéine de 20 kDa que l’on retrouve souvent sous forme de dimère. Elle est fortement conservée dans la phylogénie et on la trouve dans les levures, les plantes, les invertébrés et les mammifères. Elle est localisée dans tous les compartiments de la cellule : noyau, cytoplasme, et membranes. Il s’agit d’une protéine très abondante dans des cellules souches ainsi que des cellules en croissance exponentielle, y compris les cellules tumorales. Sa fonction principale est celle d’une « protéine de survie ». TCTP a été décrite comme interagissant avec de multiples protéines dont p53, MD

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7

Thébault, Stéphanie. "Etude des complexes entre TCTP (Translationally Controlled Tumor Protein) et ses partenaires." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T024.

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La thématique du laboratoire de l’équipe d’Adam Telerman porte sur la réversion tumorale, un processus rare au cours duquel les cellules cancéreuses perdent leur phénotype malin, et deviennent des cellules dites révertantes. Plusieurs protéines clefs impliquées dans cette transformation ont été mises en évidence, dont TCTP (Translationally Controlled Tumor Protein). La protéine TCTP est également impliquée dans la régulation de l’apoptose en interagissant et en renforçant l’activité anti-apoptotique de Mcl-1 et de Bcl-xl, deux protéines appartenant à la famille des Bcl-2. Ce projet s’attache à

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8

Andrade, Patrícia Oliveira. "Involvement of Translationally controlled tumor protein in Tomato yellow spot virus infection." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/21427.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2018-08-24T18:20:21Z No. of bitstreams: 1 texto completo.pdf: 484015 bytes, checksum: fda75b7a7bc67b7a6301406613010fcd (MD5)<br>Made available in DSpace on 2018-08-24T18:20:21Z (GMT). No. of bitstreams: 1 texto completo.pdf: 484015 bytes, checksum: fda75b7a7bc67b7a6301406613010fcd (MD5) Previous issue date: 2017-07-26<br>Fundação de Amparo à Pesquisa do Estado de Minas Gerais<br>Os vírus são as formas de vida mais abundantes e geneticamente diversas conhecidas em nossa biosfera. Para infectar hospedeiros com sucesso, os vírus

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9

Carvalho, Márcio de [UNESP]. "Estudo do papel da TCTP (Translationally Controlled Tumour Protein) na resposta ao estresses bióticos e abióticos em plantas." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92453.

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Made available in DSpace on 2014-06-11T19:26:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-09-28Bitstream added on 2014-06-13T19:12:49Z : No. of bitstreams: 1 carvalho_m_me_botib.pdf: 857762 bytes, checksum: 6884bf144951c5e915d6a1c0a0ca3e5c (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>O gene que codifica a TCTP (Translationally Controlled Tumour Protein) está presente em todos os eucariontes e o seu produto está envolvido em diferentes processos celulares. Embora bem caracterizada em mamíferos, poucos são os trabalhos disponíveis na literatura

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10

Carvalho, Márcio de. "Estudo do papel da TCTP (Translationally Controlled Tumour Protein) na resposta ao estresses bióticos e abióticos em plantas /." Botucatu, 2010. http://hdl.handle.net/11449/92453.

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Orientador: Ivan de Godoy Maia<br>Banca: Fábio Tebaldi Silveira Nogueira<br>Banca: Jomar Patricío Monteiro<br>Resumo: O gene que codifica a TCTP (Translationally Controlled Tumour Protein) está presente em todos os eucariontes e o seu produto está envolvido em diferentes processos celulares. Embora bem caracterizada em mamíferos, poucos são os trabalhos disponíveis na literatura relacionados à análise da TCTP em plantas. No presente trabalho, a expressão do gene que codifica a TCTP em tomateiros foi analisada em situações de estresse biótico e abiótico. No estresse abiótico, as plantas de toma

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11

Kim, Kevin Dae Keon. "The Translationally Controlled Tumor Protein (TCTP) associates to and destabilizes the Circadian Factor Period 2 (Per2)." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/76848.

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Period 2 (Per2) is a core circadian factor responsible for its own negative regulation. It operates in the circadian clock, which affects multiple biological functions such as metabolic rate, hormone release, and core body temperature. The Per2 protein functions directly with factors in other biological functions such as tumor suppression, immune system, and metabolism. In many cases, the Per2 deficiency caused by disrupted expression is sufficient to create severe abnormalities in many of the mentioned functions. The sequence contains several domains and motifs in Per2 that are traditionally

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12

Tuijnder, Marcel. "Biological models of tumor reversion." Paris 7, 2005. http://www.theses.fr/2005PA077085.

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13

Baylot, Virginie. "L'analyse des mécanismes d'action d'Hsp27 a mis en évidence TCTP comme nouvelle cible thérapeutique des cancers de la prostate résistants à la castration." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4021.

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Le cancer de la prostate (CaP) représente la deuxième cause de mortalité par cancer chez l'homme. La suppression androgénique (castration-thérapie) demeure la seule thérapie efficace du CaP avancé du fait de son caractère castration-sensible. Cependant, elle n'empêche pas la progression castration-résistante (CR) de la maladie dans les 1 à 3 ans après le début du traitement hormonal. Récemment, l'implication d'Hsp27 (Heat shock protein 27) dans l'échappement thérapeutique des CaPs a été montrée et un oligonucléotide antisens inhibiteur d'Hsp27, OGX-427, est en cours d'évaluation clinique II/II

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14

Duflaut, Dominique. "Etudes moléculaires et fonctionnelles des gènes TSAP6 (Tumor Suppressor Activated Pathway 6) et TCTP (Translationally Controlled Tumor Protein) : cibles pharmacologiques anti-tumorales." Phd thesis, Université Paris Sud - Paris XI, 2008. http://tel.archives-ouvertes.fr/tel-00293914.

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L'objectif de mon travail de doctorat était une caractérisation fonctionnelle des gènes TCTP et TSAP6. Ces gènes sont impliqués dans la réversion tumorale et forment un complexe protéique. <br />Tpt1, codant pour la protéine TCTP, est le gène le plus sous-exprimé lors de la réversion tumorale. L'analyse du cristal de TCTP humain montre une forte homologie entre ses hélices H2-H3 et les hélices H5-H6 de Bax. Grâce à ses hélices, TCTP inhibe l'apoptose induite par Bax au niveau des mitochondries. En effet, nous démontrons que TCTP, entre autres par le biais de ces hélices, empêche la dimérisatio

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15

Chabrier, Amélie. "Réversion tumorale pour le traitement du cancer : conception et synthèse de nouveaux inhibiteurs de la TCTP (« Translationally Controlled Tumor Protein »)." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS437.

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La réversion tumorale est un événement naturel qui conduit les cellules cancéreuses à retrouver spontanément un phénotype tumoral significativement atténué. Ce processus de reprogrammation cellulaire survient très rarement (au rythme d’une cellule par million), et suggère que des composés (petites molécules chimiques) seraient susceptibles de stimuler la réversion tumorale dans le but de constituer une nouvelle classe de médicaments novateurs pour soigner des patients atteints du cancer. Pour ce faire, la protéine TCTP (« Translationally Controlled Tumor Protein ») a été identifiée comme étant

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16

Lavoie, Jessie. "Proteomic Analysis Identifies Translationally Controlled Tumor Protein as a Potential Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24243.

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Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation of pulmonary vascular cells, such as endothelial cells (ECs). Hereditary (H) PAH is mainly caused by ―loss-of-function‖ mutations in the gene coding for the bone morphogenetic protein type II receptor (BMPR2). However, the mechanisms by which these mutations cause PAH remain unclear. The hypothesis of this thesis was that BMPR2 mutations produce an imbalance in EC protein expression and/or activity that is integrally related to the development of abnormalities in lung vascular function and struct

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17

Susini, Laurent. "Implication de Siah-1 dans la dégradation des protéines et dans l' expression des gènes durant la réversion tumorale." Paris 7, 2003. http://www.theses.fr/2003PA077115.

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18

Brioudes, Florian. "Regulation of organ morphogenesis : Functional analysis of the TRANSLATIONALLY CONTROLLED TUMOR PROTEIN and of the transcription factor BIGPETALp in Arabidopsis thaliana." Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0602.

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Dans les organismes pluricellulaires la morphogenèse nécessite une étroite régulation de la prolifération, de la croissance et de la mort cellulaire, permettant la formation d’organes aux formes et tailles bien spécifiques. Au cours de ma thèse, je me suis intéressé aux rôles biologiques de deux gènes impliqués dans la morphogenèse des organes chez Arabidopsis thaliana, TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (AtTCTP) et BIGPETALp (BPEp). J’ai montré que AtTCTP est essentiel pour le développement des plantes et que AtTCTP contrôle la progression du cycle cellulaire, au niveau de la transition

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19

Bruckner, Fernanda Prieto. "Aspectos da interação entre a proteína TCTP e o potyvírus PepYMV na infecção de tomateiro e Nicotiana benthamiana." Universidade Federal de Viçosa, 2012. http://locus.ufv.br/handle/123456789/5355.

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Made available in DSpace on 2015-03-26T13:51:57Z (GMT). No. of bitstreams: 1 texto completo .pdf: 1092167 bytes, checksum: 8586b9a4bcc728e0319bbbdb012ca136 (MD5) Previous issue date: 2012-07-19<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Viruses are organisms with small genomes of simple organization, which coding about 3 to encode 10 viral proteins. The success of the infection depends on the manipulation of the cell by the virus, by means of complex interactions occurring between viral factors and host factors. The induced changes by virus infection include cell morph

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20

Wippermann, Barbara. "Functional characterisation of the TCTP gene : a role in regulation of organ growth." Thesis, Lyon, École normale supérieure, 2013. http://www.theses.fr/2013ENSL0814.

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La croissance d’un organisme multicellulaire pour atteindre une taille bien définie, nécessite une coordination de la prolifération cellulaire, de l’expansion et de la différentiation cellulaire ainsi que de la mort cellulaire. Ces processus sont sous l’influence de l’état nutritionnel de l’organisme, les conditions de son environnement et des signaux hormonaux. Translationally controlled tumor protein (TCTP) est un facteur essentiel à la croissance des plantes et des animaux. La protéine TCTP de plante contrôle la croissance mitotique, tandis que la protéine TCTP animale contrôle la croissanc

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21

Savarin, Julie. "Caractérisation de la voie TCTP (TRANSLATIONALLY CONTROLLED TUMOR PROTEIN) chez Arabidopsis thaliana : identification des régulateurs de son accumulation et importance de la voie au cours du développement embryonnaire." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN001.

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TCTP (Translationally Controlled Tumor Protein) est une protéine très conservée chez l'ensemble des eucaryotes. C’est une protéine vitale impliquée dans divers processus essentiels, et pour de nombreux organismes son absence conduit à la létalité dès les stades embryonnaires.Chez les animaux comme chez les végétaux, TCTP joue un rôle primordial dans la croissance et le développement des individus. En plus de son implication dans l’apoptose et la réparation de l’ADN, TCTP favorise la prolifération cellulaire, et se trouve donc être un élément important de la tumorigenèse. Chez les végétaux, la

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22

Hassan, Dhiya. "Forced Overexpression of Translationally Controlled Tumor Protein (TCTP/TPT1) Induces a Growth-Dysregulated Phenotype in Endothelial and Smooth Muscle Cells: Role of TCTP Exosomal Export in Paracrine Cell-Cell Signaling Induced by Endothelial Injury." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38674.

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Background: Pulmonary arterial hypertension (PAH) is a lethal disease for which the fundamental molecular mechanisms are only partially understood. Existing therapies, which primarily focus on endothelial dysfunction, have limited effects on improving outcomes. Increases in pulmonary vascular resistance in PAH may be attributed to complex lung arterial remodeling which result in obliterative “plexiform” lesions, a pathological hallmark of this disease. Recent studies have shown that endothelial cell (ECs) apoptosis may be a central trigger for PAH, resulting in the emergence of growth-dysregul

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23

Thiele, Holger. "Struktur und Funktion des Gens für das translationell kontrollierte Tumorprotein (TCTP)." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14496.

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Das translationell kotrollierte Tumorprotein (TCTP) ist ein bei Eukaryonten vorkommendes hochkonserviertes Protein, das eine Rolle bei der Pathogenese allergischer Erkrankungen spielt. Bei atopischen Kindern vermittelt es eine IgE abhängige Histaminfreisetzung aus basophilen Granulozyten. Die zugrundeliegenden Mechanismen sind jedoch unklar. TCTP hat die Eigenschaft, an das Tubulin des Zytoskeletts der Zelle zu binden und besitzt eine hohe Affinität für Kalzium. Seine Synthese wird auf dem transkriptionellen und translationellen Niveau reguliert. Eine früher angenommene spezifisc

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24

Branco, Remi. "Functional analysis of a putative master regulator of plant development, the Translationally-Controlled Tumour Protein." Phd thesis, 2020. http://hdl.handle.net/1885/209920.

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Being sessile, plants need to accurately coordinate leaf and root growth to adapt to changing environmental conditions. TCTP (Translationally Controlled Tumour Protein) belongs to a conserved gene family, present in all eukaryotes. In animals, TCTP controls several core cellular processes including apoptosis, cellular proliferation and growth, tissue patterning, and is thought to interact with the TOR (Target Of Rapamycin) pathway. Plant TCTPs are little known, however, but recent studies suggest functional similarities with animal TCTPs. What functions they assume is still a matter of debate

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25

Leclercq, Tamara Marie. "Regulation of sphingosine kinase by interacting proteins." Thesis, 2010. http://hdl.handle.net/2440/64752.

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Sphingosine kinase 1 (SK1) is responsible for phosphorylating the lipid sphingosine, generating the bio-active phospholipid, sphingosine 1-phosphate (S1P). Cells possess basal SK1 activity which has been proposed to serve in a ‘housekeeping’ function to limit the levels of proapoptotic sphingosine and ceramide in the cell. In some circumstances, however, such as cell exposure to growth factors and cytokines this basal level of SK1 activity is increased, resulting in an increased production of S1P. As S1P is a pro-proliferative, pro-survival molecule, its increased production is associated with

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26

Roque, Cláudio André Gouveia Martins. "A Role for Tctp in Neural Circuitry Formation." Doctoral thesis, 2015. http://hdl.handle.net/10316/28232.

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Tese de doutoramento em Biociências, ramo de especialização em Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>With 86 billion neurons in the human brain, the ordered array of neuronal pathways is an exceptionally complex web of accurately connected axonal and dendritic processes, ultimately allowing us to perceive the world and respond consciously to it. Precise wiring of the nervous system is therefore the cornerstone of its intricate functions. Neuronal connectivity begins to take shape during

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