Дисертації з теми "Transgenic Mice"
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Simard, Marie-Chantal. "Nef pathogenesis in transgenic mice." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103182.
Therefore, it appears that SIV Nef alone expressed in mice, in appropriate cell types and at sufficient levels, can elicit many of the phenotypes of simian and human AIDS. These Tg mice should be instrumental in studying the pathogenesis of SIV Nef-induced phenotypes.
Husbands, Sandra D. "Tolerance and immunity in transgenic mice." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303680.
Cosentino, Lidia. "A comparison of transgenic and endogenous loci in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ56223.pdf.
Malmström, Vivianne. "Arthritis susceptibility and tolerance in collagen transgenic mice." Lund : Dept. of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38986502.html.
So, Chi-leung. "Transgenic mouse model of human chondrodysplasia /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19161347.
Gratao, Ana Angélica. "Impaired fertility in transgenic mice overexpressing betacellulin." [S.l.] : [s.n.], 2007. http://edoc.ub.uni-muenchen.de/archive/00006575.
Gratao, Ana Angelica. "Impaired Fertility in Transgenic Mice Overexpressing Betacellulin." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-65751.
Felmer, R. "Genetic manipulation of fat in transgenic mice." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650832.
Cox, April. "Effects of hyperoxia in alzheimers transgenic mice." Scholar Commons, 2005. http://scholarcommons.usf.edu/etd/2836.
Calver, Andrew Robert. "Oligodendrocyte population dynamics : insights from transgenic mice." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322239.
Derrett-Smith, E. C. "Systemic sclerosis vasculopathy : exploration in transgenic mice." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383812/.
蘇志良 and Chi-leung So. "Transgenic mouse model of human chondrodysplasia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31237678.
衛永剛 and Wing-kong Wai. "Abnormal chondrocyte differentiation: a transgenic model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237800.
Wai, Wing-kong. "Abnormal chondrocyte differentiation : a transgenic model /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19656439.
Thomas, Alysia D. "Endocrine mechanisms for reproductive failure and transgene transmission in oMt1a-oGH transgenic mice /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.
Myelnikov, Dmitriy. "Transforming mice : technique and communication in the making of transgenic animals, 1974-1988." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252737.
Lemon, Jennifer Rollo C. David. "Oxidative stress and aging processes in transgenic growth hormone mice." *McMaster only, 2005.
Oghumu, Steve Onyeka. "Generation and Characterization of CXCR3 Bicistronic Reporter Mice and CXCR3 Transgenic Mice." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274927351.
Rizzo, Stefania. "Arrhythmogenic cardiomyopathy: electrical instability and intercalated disc abnormalities in transgenic mice." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426181.
Introduzione: Mutazioni nei geni che codificano per le proteine desmosomali giocano un ruolo fondamentale nella patogenesi della cardiomiopatia aritmogena del ventricolo destro (ARVC). Tuttavia, le conseguenze di tali mutazioni negli stadi precoci della malattia sono sconosciute. Scopo del nostro studio è stato di indagare se il rimodellamento dei dischi intercalari come conseguenza di mutazioni nelle proteine desmosomali modifichi le proprietà elettrofisiologiche cardiache prima dello sviluppo di morte cellulare e fibrosi sostitutiva. Metodi e Risultati: Topi transgenici con overespressione cardiaca della proteina Desmogleina2 mutata (Dsg2) -Dsg2-N271S (Tg-NS/L)- sono stati studiati prima e dopo lo sviluppo di morte miocitaria e fibrosi sostitutiva. Come controlli, abbiamo usato topi wild-type e topi con overespressione della Dsg2 normale. Studi di microscopia elettronica hanno evidenziato la presenza di spazi intercellulari allargati in corrispondenza delle giunzioni meccaniche desmosomi/giunzioni aderenti nei topi Tg-NS/L prima dello sviluppo di necrosi e fibrosi. Contemporaneamente, il mappaggio epicardico in cuori perfusi con soluzione Langendorff ha dimostrato prolungamento del tempo di attivazione ventricolare, riduzione della velocità di conduzione longitudinale e trasversale, ed aumento della inducibilità di aritmie. Inoltre, nello stesso stadio di malattia, si osservava ridotta velocità del potenziale d’azione dovuta a minore densità della corrente del sodio. Studi di co-immunoprecipitazione, infine, dimostravano un’interazione in vivo tra la Dsg2 e la proteina NaV1.5 dei canali del sodio. Conclusioni: Un allargamento degli spazi intercellulari a livello dei dischi intercalari e una concomitante riduzione del potenziale d’azione, come conseguenza di una minore corrente del sodio, portano ad un ritardo di conduzione ed ad aumentata suscettibilità aritmica negli stadi di malattia che precedono la necrosi e la fibrosi sostitutiva. La dimostrazione di un’interazione in vivo tra Dsg2 e NaV1.5 suggerisce una spiegazione a livello molecolare dei disturbi elettrici osservati negli stadi precoci dell’ARVC.
Wootz, Hanna. "Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7342.
Andäng, Michael. "Expression and function of ribozymes in transgenic mice /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4143-2/.
Wang, Jianming. "Life without mitochondrial DNA : studies of transgenic mice /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4491-1/.
Salem, Hatem. "Behavioural analysis of transgenic mice overexpressing gamma-synuclein." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/32398/.
Scudamore, Owen. "Modelling Parkinson's disease with α-synuclein transgenic mice". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/modelling-parkinsons-disease-with-alphasynuclein-transgenic-mice(2c799251-df3c-43f8-8b29-866d06179512).html.
Emson, Claire Lucy. "Analysis of interleukin-13 function using transgenic mice." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624439.
Downing, Alison. "Generation of Ren-2/SV40 TsTAg transgenic mice." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/13711.
Klomkleaw, Wuthichai. "ATF3 transgenic mice : structural analysis of cardiac myocytes /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486457871785014.
Yamada, Go. "Generation of Transgenic Mice Overexpressing a Ghrelin Analog." Kyoto University, 2011. http://hdl.handle.net/2433/135383.
Collette, Nicole Marie. "Characterization of obesity in oMt1a-oGH transgenic mice /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
Page, Raymond Lynn. "Evaluation of techniques for the production of transgenic animals." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.
Page, Raymond L. "Evaluation of techniques for the production of transgenic animals." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.
Ph. D.
Chung, Chi-kin Samuel. "The development and characterization of a gene-knockout mouse model for secretin receptor /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31491121.
Yang, Xiu. "Altered neuronal lineages in the facial ganglia of Hoxa₂ mutant mice." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1207189742.
陳醒覺 and Sing-kwok Chan. "Mouse preproendothelin-1 gene: transgenic mouse models to study tissue-specific and developmental expression andregulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31236571.
Rojas, JoseÌ-Manuel. "Identification of novel immunogenic HLA-DR-restricted peptides from tumour-associated antigens." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273771.
Gilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.
Siu, Kwan-yin. "The development and characterization of a knockout model for secretin." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40887674.
Chan, Sing-kwok. "Mouse preproendothelin-1 gene : transgenic mouse models to study tissue-specific and developmental expression and regulation /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19737002.
Lee, Yin-ting. "Molecular characterization of the insertional mouse mutant yellow submarine, Ysb /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24709372.
Wood, Stephen Andrew. "V-myc expressing transgenic mice generated by recombinant retroviral infection." Thesis, The University of Sydney, 1990. https://hdl.handle.net/2123/26388.
Canseco-Sedano, Rodolfo. "Factors affecting the efficiency of gene transfer in mice." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-03172010-020810/.
Groom, Joanna Ruth School of Medicine UNSW. "Loss of immune regulatory checkpoints in BAFF transgenic mice." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/27281.
Zhu, Lei 1980. "Perturbed B cell development in young B7.2 transgenic mice." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84090.
Mao, Jian-Hua. "Stochastic modelling of tumorigenesis in p53 deficient transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286124.
Thomas, Thomas David Colin. "Immunoregulation in the NOD mouse and NOD transgenic mice." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612992.
Kim, Youngwoo. "Generation of transgenic mice for conditional overexpression of Sox9." Kyoto University, 2013. http://hdl.handle.net/2433/174810.
Spratt, Christopher. "Development of behavioural tasks for phenotyping of transgenic mice." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23201.
Costa, Vivian. "Effects of overexpressing ASIC2a and ASIC3 in transgenic mice." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/1132.
Kashinathrao, Mamta. "Recurrent genetic alterations in thymic lymphomas of LckMyrAkt2 transgenic mice." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432499.
凌錦榮 and Kam-wing Ling. "Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238993.