Дисертації з теми "Toxicity testing In vitro"
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Radburn-Smith, Marcus Alexander. "Novel in vitro models and methods for ocular toxicity testing." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443263.
Yang, Jie. "Three dimensional perfused cell culture for in vitro toxicity testing." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:a72b7015-cc57-4bb8-904a-a5a88e2194f1.
Lestari, Fatma Safety Science Faculty of Science UNSW. "Development of in vitro toxicity methods for fire combustion products." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24280.
Lawrence, J. N. "Cryopreservation and toxicity studies with cultured rat and human hepatocytes." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233123.
Bruschi, Sam A. "Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /." Title page, abstract and table of contents only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phb192.pdf.
Yu, Lok Chiu. "Cellular metabolism in in vitro toxicity and toxicology studies." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/675.
McKay, Gillian Claire. "Cryopreservation of hepatocyte monolayers : a potential in vitro model system for toxicity testing." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366885.
Bakand, Shahnaz Safety Science Faculty of Science UNSW. "Development of in vitro methods for toxicity assessment of workplace air contaminants." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24246.
Pu, Yubing. "Toxicity assessment of engineered nanoparticles." Thesis, Troyes, 2017. http://www.theses.fr/2017TROY0001/document.
The objective of this thesis is to improve understandings of toxicity of various engineered nanoparticles (ENPs) to human and ecosystem. It is realized via coordinating toxicological data and a scientific consensus environmental model -- the USEtox model. As an important element in life cycle impact assessment, the characterization factor (CF) is employed as a toxicity indicator for human and ecosystem in this work. To obtain the firsthand dose-response phenomena and human toxicological data, in vitro experiments have been conducted by exposing freshly isolated porcine neutrophils to three kinds of ENPs (i.e. copper, nickel and aluminum oxide nanoparticles). The morphologies, mortality rates, and chemiluminescence, of neutrophils are observed or monitored. Additionally, to estimate the persistence time of ENPs in freshwater ecosystem, a fate model on the basis of colloid science is developed. It takes nano-specific behaviors of ENPs into account and includes recommendations of regionalized hydrological parameters. Finally, a comprehensive literature survey is accomplished to collect the ecotoxicological data of various ENPs. Under the framework of USEtox model, the non-carcinogenic human toxicological CFs for Copper NPs and the ecotoxicological CFs for 14 ENPs are recommended. These CF values could be useful in the future when evaluating the environmental impacts of products containing ENPs
Berkelind, Ellinor. "In vitro bioassays for toxicity testing of wastewater - an evaulation of different sample treatment techniques." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412525.
Cadieux, Brigitte. "Development of a novel, rapid, in vitro assay for the detection of Clostridium botulinum neurotoxin type E." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32836.
The specificity of the antisera was increased by adsorbing cross-reactive antibodies from whole antisera with affinity columns made with total proteins from culture supernatants of closely related clostridia. Alternatively, specific antibodies were isolated with an affinity column prepared with C. botulinum type E toxoid.
Different methods of concentrating BoNT/E in each sample prior to testing them were evaluated to increase the sensitivity of the assay.
The slot blot immunoassay was then evaluated for detection of BoNT/E in mixed cultures and in food samples. (Abstract shortened by UMI.)
Masango, Mxolisi Goodwill. "A comparative analysis of the cytotoxicity of cyanotoxins using in vitro (cell culture) and in vivo (mouse) assays." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-100402/.
Nicholls-Grzemski, Felicity April. "The effect of short-term pretreatment with peroxisome proliferators on the acute toxicity of various toxicants, including paracetamol /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phn6158.pdf.
Manglik, Aparna Safety Science Faculty of Science UNSW. "Development of comparitive methods for chemical analysis and in vitro cytotoxicity testing of contaminated sites." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/25168.
Sega, Estela Munhoz. "Determinação da toxicidade in vitro e in vivo de novos organofosforados e ressonancia magnetica nuclear do cloreto de acetilcolina." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311381.
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-06T21:30:04Z (GMT). No. of bitstreams: 1 Sega_EstelaMunhoz_M.pdf: 1403353 bytes, checksum: 0aec5b888298032d359cc1b3cf0905b6 (MD5) Previous issue date: 2006
Resumo: Esse estudo analisou as propriedades toxicológicas de novos compostos organofosforados. Foram realizados experimentos para avaliar a atividade anticolinesterásica desses organofosforados, in vitro, no sangue total através do método de Ellman modificado. Para determinar a sua citotoxicidade foram utilizadas células PC 12, com as quais avaliamos a viabilidade celular após contato com os organofosforados e determinamos a IC 50, encontrando valores muito diferentes para os diversos organofosforados estudados. Estudos de toxicidade aguda in vivo foram realizados com camundongos, através da metodologia recomendada pela OECD nos quais determinamos a DL50 para três dos organofosforados estudados, sendo que um apresentou toxidade moderada. Foram analisados os efeitos dos solventes nas constantes de acoplamento JHH, JHH, JNC e 2Jnc em espectros de RMN de LH e 13C do cloreto de acetilcolina. Os valores das constantes de acoplamento em solventes de diferentes constantes dielétricas (s) não sofreram variações, indicando uma ausência de efeitos de solvente no equilíbrio conformacional do cloreto de acetilcolina (ACh). As constantes de acoplamento mostram que o sistema OCH2CH2N+ tem uma conformação gaúche (sinclinal). O Jnh e Jkc são observados na maioria dos solventes, mas não em solventes clorados e não são dependentes da viscosidade do solvente, esse comportamento foi explicado usando dados de medidas de Ti. Os valores dos coeficientes de difusão de RMN mostraram que a ACh tem uma grande tendência de se agregar quando dissolvida em solventes clorados, fato que pode explicar as diferenças observadas em valores de T1 para o 14N
Abstract: This study analyzed the properties of the news organophosphorus. Experiments had been carried through to evaluate the inhibition of acetylcholinesterase of these organophosphorus, in vitro, through the modified EUman's method. In order to determine its cytotoxicity cells PC 12 had been used, with which we evaluate the cellular viability after contact with the organophosphorus and determined the IC50, different values were found for the diverse organophosphorus. Studies of acute toxicity had been carried through with mice, following the methodology recommended by the OECD in which determine the DL50 for three of the organophosphorus studied, being that one presented moderate toxicity. Coupling constants values ( Jhh and Jnc) obtained from the 'H and 13 C NMR spectra of acetylcholine chloride (ACh) in several solvents with a wide range of dielectric constants (e) are remarkably invariant, indicating an absence of solvent effects in the conformational equilibrium of this compound. Those values show that the OCH2CH2N+ system occurs in a synclinal conformation. The Jnh and Jnc are observable in most solvents, but not in chlorine-containing solvents and are not dependent on solvent viscosity. This behavior was explained using data from Ti measurements. The measurement of NMR diffusion coefficients show that ACh has a greater tendency to aggregate when dissolved in chlorinated solvents, a fact that could explain the observed differences in 14N T1
Mestrado
Patologia Clinica
Mestre em Ciências Médicas
Haglund, Caroline. "Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications." Doctoral thesis, Uppsala universitet, Klinisk farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150361.
Greenan, Rebecca. "Optimization of the VITROCELL® Exposure System for In Vitro Toxicity Testing of Diesel Emissions at the Air-Liquid Interface." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32254.
Morrison, Roxanne. "The development of an in vitro system for the production of drug metabolites using microsomal enzymes from bovine liver." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1007698.
Bellwon, Patricia [Verfasser], Wolfgang [Gutachter] Dekant, and Martin [Gutachter] Müller. "Kinetic assessment by in vitro approaches - A contribution to reduce animals in toxicity testing / Patricia Bellwon. Gutachter: Wolfgang Dekant ; Martin Müller." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1111784213/34.
Reichel, Carmela Marie. "The effects of neonatal manganese exposure on impulsivity, unlearned motoric function, and reward." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2788.
Wickramaratna, Janith C. "A pharmacological characterisation of death adder (Acanthophis Spp.) venoms and toxins." Monash University, Dept. of Pharmacology, 2003. http://arrow.monash.edu.au/hdl/1959.1/5514.
Chapman, Laurie A. "Interactions of nutrients on methyl mercury toxicity in neuron X spinal chord hybrid cells (NSC-34) and human oligodendrocyte X rhabdomyosarcoma cells (MO3.13)." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36888.
Procópio, Andréa Lemos Falcão. "Efeito antimicrobiano residual e citotoxidade in vitro de resina acrílica para base de prótese após imersão prolongada em agentes de limpeza." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25146/tde-26102015-103717/.
This in vitro study aimed to evaluate the long-term residual antimicrobial activity and cytotoxicity of chemical denture cleansers incorporated into a heat-polymerized acrylic resin after successive cycles of daily overnight soaking. Discs (10mm x 1mm) were prepared from heat-polymerized acrylic resin (Lucitone 550) and submitted to three daily immersion (8h/each) in 1% sodium hypochlorite (NaClO), chlorhexidine digluconate 2% (CHX) or distilled water (control) for 91 days (T91) or 183 days (T183), simulating the period of 9 months or 1.5 year of nocturnal immersion performed by the patient. Initially, the method of minimum inhibitory concentration in broth was used to determine the possible residual effect (incorporation) of the acrylic resin solution. Half of the disks immersed in each cleaning agent for one of the period immersion (n=5) was inoculated (1x107cells/mL) with pathogens associated with denture stomatitis: Candida albicans (Ca) or Staphylococcys aureus (Sa). The disks were incubated at 37oC for analysis in a spectrophotometer after 24h, 7 and 14 days. The absorbance values were expressed as percentages of microbial inhibition. Confirmed the residual antimicrobial action of cleaning agents incorporated into the acrylic resin, its cytotoxicity was analyzed in vitro on human gingival fibroblasts (L929). Cytotoxic effects were evaluated by the colorimetric assay MTT [3- (4,5- dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide] to determine cellular viability after the cells were exposed for 24h to the samples of each experimental condition (n=18) previously immersed in one of the solutions for the evaluation periods (T91 or T183). Cytotoxicity was determined based on mitochondrial activity compared to the specimens not subjected to immersion in the solutions. The MTT assay results were 1-way ANOVA followed by Tukey\'s HSD post-hoc test (a=0.05). For the periods T91 and T183, no microbial inhibition was observed with immersion in water (control) for up to 14 days of incubation. The CHX progressively inhibited microbial growth over the 14 days for both immersion times (Ca: 19 to 73.58%, Sa: 0 to 87.08%); with greater antimicrobial activity in T183. The NaClO showed a slight microbial inhibition only in the 14-day period in both T91 (Ca: 0%; Sa: 2.70%) and T183 (Ca: 8.50%; Sa: 15.08%). According to the results of the MTT assay, the chemical cleaning solutions tested showed a significant reduction in cell viability when compared to the control cells propagated in normal culture medium (p<0.002). The CHX resulted in the lowest cell viability in both immersion periods (p<0.018). The acrylic samples immersed in water or NaClO in T91 and T183 showed cell viability statistically similar to nonimmersed samples (p>0.05). CHX incorporated into the acrylic resin denture base had a residual antimicrobial effect on both immersion periods, which was not observed with NaClO. On the other hand, the residual CHX were severely cytotoxic to human gingival fibroblasts compared to NaClO and distilled water which were slightly cytotoxic. These results suggest caution in selecting denture cleaning agents as a method of prevention and adjunct treatment of denture stomatitis because even at low concentrations recommended for overnight immersion, they may exhibit some degree of toxicity to the denture bearing mucosa.
Widdowson, Alexandra. "Microbial toxicity testing of inorganic nanoparticles." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=227625.
Macdonald, Niall Patrick. "Microsystems manufacturing technologies for pharmaceutical toxicity testing." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5070/.
Taylor, Nadine Suzanne. "Novel approaches to toxicity testing in Daphnia magna." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/668/.
Holmes, Jan L. "Development of functional in vitro toxicity tests." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10976/.
Derache, Philippe. "Influence de la reduction des xenobiotiques organo-nitres sur la peroxydation des phospholipides." Toulouse 3, 1986. http://www.theses.fr/1986TOU30062.
Payne, Chris 1971. "Phylogenetic trends in phytoplankton resistance to Cd and Cu toxicity." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24033.
Adler, Sarah. "The use of pluripotent cells in developmental toxicity testing." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976069806.
Naidoo, Vinasan. "Diclofenac in Gyps vultures a molecular mechanism of toxicity /." Electronic thesis, 2007. http://upetd.up.ac.za/thesis/available/etd-07032008-093716/.
Mitchell, Roger Dale 1955. "Systemic indicators of inorganic arsenic toxicity in several species." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276678.
Cikutovic, Salas Marcos A. "Pathologies in earthworms: sublethal biomarkers of xenobiotic toxicity." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798085/.
Kane, Amadou. "Intoxication subchronique par l'ochratoxine a, mycotoxine contaminant les aliments : effets nephrotoxiques et genotoxiques." Strasbourg 1, 1986. http://www.theses.fr/1986STR13126.
Juchelka, Charlotte Milada. "Rapid toxicity assessment using ingestion rate as a sublethal biomarker." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25413.
Johnson, Clint Edwin. "In vitro toxicity assessment of silver and zinc oxide nanoparticles." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0119.
Keynes, Robert Geoffrey. "Nitric oxide reactivity and toxicity in brain tissue in vitro." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446781/.
Dhakal, Kiran. "Comparative in vitro estimates of inhalation toxicity of selected nanoparticles." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1639.
Cookson, Mark R. "Studies of activation and toxicity in cultured astrocytes." Thesis, University of Salford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308094.
Nielsch, A. S. "Effects of prostaglandins and prostaglandin synthetase inhibitors on liver toxicity." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU499301.
Burbank, Susan Elizabeth. "Development of rapid toxicity tests using enzyme inhibition as sulethal biomarker." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25401.
Högberg, Helena. "Developmental Neurotoxicity Testing Using In vitro Approaches." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30056.
The work of this thesis was performed at ECVAM, European Commission, Italy.At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: In press. Paper 3: In progress. Paper 4: In progress.
Högberg, Helena. "Developmental Neurotoxicity Testing Using In vitro Approaches." Stockholm : The Wenner-Gren Institute, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30056.
The work of this thesis was performed at ECVAM, European Commission, Italy. At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: In press. Paper 3: In progress. Paper 4: In progress. Härtill 4 uppsatser.
Middendorf, Paul Joseph. "Development and evaluation of toxicity tests using Caenorhabditis elegans with reproduction, mutation, lethality, and behavior as end points." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25201.
Lai, Keng Po. "Study on the environmental contamination and mechanistic toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/527.
Mochan, Daria Galina. "Evaluation of a Rapid-screening Toxicity Test Using the Ciliate, Colpoda inflata (Stokes): Sensitivity and Bioavailability to Model Compounds." PDXScholar, 1996. https://pdxscholar.library.pdx.edu/open_access_etds/5165.
Davies, Joanna. "Synthesis of zwitterionic compounds for aquatic toxicity testing for QSAR correlation studies." Thesis, Swansea University, 2003. https://cronfa.swan.ac.uk/Record/cronfa42651.
Everitt, Victoria Jane. "The use of indigenous macroinvertebrates and Daphnia pulex in acute toxicity testing." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1005483.
Fortner, Jason C. "Illuminating whole effluent toxicity testing : ultraviolet radiation, phototoxicity, and PAH-contaminated groundwater /." Online version, 2009. http://content.wwu.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=314&CISOBOX=1&REC=10.
Bramble, Lisa Anne. "Utilization of mitochondrial and microsomal metabolism for the assessment of toxicity." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03122009-040409/.