Дисертації з теми "TMD PDF"
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Takekawa, Stefano. "Study of T-odd parton distribution functions in polarised Drell-Yan processes at COMPASS." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3722.
Повний текст джерелаLo studio di processi di Drell-Yan (DY) polarizzato permette di accedere alle funzioni di distribuzione partoniche dipendenti dal momento intrinseco trasverso (TMD PDF) che sono usate per descrivere la struttura del protone. La proposta di misura di T-odd TMD PDF (funzioni di Sivers e di Boer-Mulders) è in scrittura e verrà presentata all'SPS Committee. Essa illustra l'intezione di usare lo spettrometro dell'esperimento COMPASS al CERN per effettuare questa misura studiando eventi di Drell-Yan polarizzato. Simulazioni di Monte Carlo sono state effettuate e sono riportate le analisi dei dati raccolti durante i test di DY svolti alla fine dei run di COMPASS degli anni 2007, 2008 e 2009.
The study of Drell-Yan (DY) processes allows to access to the transverse momentum dependent parton distribution functions (TMD PDF) which are used to describe the structure of the proton. The proposal of measure of T-odd TMD PDF (Sivers and Boer-Mulders functions) has been written and it will be submitted to the SPS Committee. It is about the use of the COMPASS spectrometer at CERN to perform this measure via Drell-Yan processes. Monte Carlo simulations were done and the analysis of the data collected during the DY test at the end of 2007, 2008 and 2009 runs are reported.
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Filho, José Dirceu Vollet. "\"Identificação e quantificação de fotossensibilizador em tecido hepático por espectroscopia de fluorescência e sua importância na terapia fotodinâmica\"." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-28032007-180658/.
Повний текст джерелаPhotodynamic Therapy (PDT) is a technique that implies in cell damage by the action of a photosensitizer (PS) with tumor tissue localization selectivity; light at PS absorption spectrum wavelengths, which leads the PS to a metastable triplet state; and molecular oxygen, which earns the energy absorbed by the PS, reaching a high oxidative potential singlet state. The technique has found sucess on the treatment of lesions as cancer. However, it finds difficulties for its dosimetry stablishment, like the quantification of PS distribuition in a photosensitized tissue. This work has three purposes: obtainance of fluorophores quantitative information into turbid media through fluorescence spectroscopy; to show the distribution of the PS Photogem® in healthy Wistar rats livers and its consequences on dosimetry; and the upgrade of an existing model for depth of necrosis (Ynec) forecast. There were three experimental stages: the first one was an attemp to rebuild a healthy liver spectrum from a composition using mathematical weights for isolate liver endogenous fluorophores spectra. On the second stage, in vitro and in vivo studies were performed using Coralim-Mix® blue, green and red food dyes and the Exciton® dyes Coumarin-480 and LDS-722, aiming to recover dyes spectra from dyes in turbid solutions and dyes mixtures. On the third one, Photogem® was administered to Wistar rats and fluorescence was collected on rats livers, and a relationship was stablished between the changes on fluorescence intensity, PS concentration in the tissue and necrosis profiles obtained via PDT. Results were applied to the upgrade of the Ynec forecast model. Spectra rebuilding, as well as dyes spectra recovering, were not completely reached. Results showed that a great deal of factors contribute to distortions at the collected fluorescence. It was verified that PS distribution is inhomogeneous in a photosensitized organ. It was found a function for the PS tissue distribution and it made possible to upgrade the Ynec forecast model. It was showed that medium turbidity affects in a complex manner the collected fluorescence, making difficult to quantify directly fluorophores in such medium. A need to go deeper into the investigation of light interactions with turbid media so that we may remove distortions they introduce into fluorescence spectra became evident. It was also showed how important is to track PS distribuition in a photosensitized tissue as a part of PDT dosimetry, and how fluorescence spectroscopy seems to be appropriate to perform such tracking, as long as the difficulties on fluorescence collection are overcome.
Castex, Elodie Grasland Loïc. "Le transport à la demande (TAD) en France." Villeurbanne : TEL, 2008. http://tel.archives-ouvertes.fr/docs/00/26/87/13/PDF/These.E.Castex_2007_V2.pdf.
Повний текст джерелаPerez, Priego Juan Gabriel. "Ad-Hoc Sharing for Palm Devices." ScholarWorks@UNO, 2005. http://scholarworks.uno.edu/td/239.
Повний текст джерелаCastex, Elodie. "Le Transport A la Demande (TAD) en France : de l'état des lieux à l'anticipation. Modélisation des caractéristiques fonctionnelles des TAD pour développer les modes flexibles de demain." Phd thesis, Avignon, 2007. http://tel.archives-ouvertes.fr/docs/00/26/87/13/PDF/These.E.Castex_2007_V2.pdf.
Повний текст джерелаDemand Responsive Transport (DRT) is a type of public transportation which combines the advantages of collective transport and taxi. It has often been considered as a marginal means of transportation reserved to low density territories. Since the end of 90s, the number of DRT services has increased regularly. A database of 615 services shows that DRT services invest new territories such as urban, suburban or rural spaces. They offer a large variety of operating services, which are described by using several models we designed (functional, statistical and graphical models). The last part of the thesis is devoted to the flexibility of the DRT, a survey is analysed to discuss the reliability of future DRT services. Three examples illustrate the flexible DRT potentialities for public transportation networks
Ustunel, Eser Kwon Hyuck M. "Time division duplex-wideband code division multiplex (TDD-WCDMA)." Diss., Click here for available full-text of this thesis, 2006. http://library.wichita.edu/digitallibrary/etd/2006/t029.pdf.
Повний текст джерела"May 2006." Title from PDF title page (viewed on October 19, 2006). Thesis adviser: Hyuck M. Kwon. Includes bibliographic references (leaves 40-42).
Nebbe, Brian. "Adolescent facial morphology and TMJ internal derangement." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/NQ29085.pdf.
Повний текст джерелаRossmanith, David A. Jr. "Poroacuatics Under Brinkman's Model." ScholarWorks@UNO, 2016. http://scholarworks.uno.edu/td/2183.
Повний текст джерелаLongstaffe, Margery A. "The prophet unmasked, the poetry of Ted Hughes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0008/MQ33247.pdf.
Повний текст джерелаMora, Espí Inmaculada. "Photosensitizers and microparticles as tools against malignant cells." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664179.
Повний текст джерелаEn los últimos años, se han desarrollado diversas estrategias para destruir específicamente células cancerosas y minimizar los efectos secundarios en células sanas. Una de estas estrategias es la terapia fotodinámica (PDT), una técnica que utiliza un fotosensibilizante (PS) y luz de una longitud de onda concreta, en presencia de oxígeno. Cuando el PS es excitado por la luz, produce especies reactivas del oxígeno (ROS) que inducen la muerte de las células circundantes. Para dirigir selectivamente los PSs hacia las células diana, éstos pueden vehiculizarse en nano- y micropartículas (NPs y µPs, respectivamente). En este sentido, biofuncionalizar NPs o µPs con PSs y con moléculas capaces de reconocer las células malignas debería permitir hacer tratamientos más selectivos con PDT. Otra estrategia para destruir células malignas es el uso de otros fármacos terapéuticos que interaccionen con dianas intracelulares para matar la célula. Estos fármacos también pueden ser vehiculizados en NPs o µPs para dirigirlos con más eficiencia a las células diana, pero la mayor limitación de este enfoque es que tras la internalización pueden quedar atrapados junto a sus vehículos en el compartimento endolisosomal. Para superar este problema, se han desarrollado estrategias como la internalización fotoquímica (PCI), que se basa en los mismos principios que la PDT pero, en este caso, el PS se acumula en las membranas endolisosomales, que sufren una disrupción tras la excitación del PS, permitiendo la liberación del contenido endolisosomal hacia el citosol. El objetivo de la presente tesis es contribuir al desarrollo de las estrategias mencionadas previamente, para eliminar selectivamente células malignas. En el primer trabajo, los tratamientos fotodinámicos con dos PSs (Na-H2TCPP y su derivado de zinc Na-ZnTCPP) indujeron un descenso en la supervivencia de células tumorales (SKBR3) y no tumorales (MCF10A), aunque éstas últimas mostraron mayor resistencia a bajas concentraciones de ambos PSs. Además, según el PS y la línea celular se desencadenaron diferentes mecanismos de muerte celular, hecho que podría explotarse para proteger selectivamente las células no malignas durante los tratamientos fotodinámicos. En el segundo trabajo, se demostró que HER2, sobreexpresado en células de algunos tipos de cáncer, era una diana adecuada para dirigir µPs biofuncionalizadas con anti-HER2. También demostramos que diferentes condiciones de cultivo (mono o cocultivos en sistemas estáticos o microfluídicos), influenciaban la internalización de las µPs, lo que puso de relieve la importancia de realizar estudios sobre las interacciones entre µPs y células en condiciones más similares a las existentes in vivo. Finalmente, en nuestro tercer trabajo observamos que la PCI induce eficazmente la disrupción de las membranas endolisosomales, permitiendo la liberación de moléculas solubles hacia el citosol, pero no una desintegración completa de la membrana, lo que sería necesario para la liberación de las µPs atrapadas. En conclusión, la presente tesis proporciona nuevo conocimiento para el desarrollo de mejores agentes terapéuticos y tratamientos basados en el uso de PSs y µPs para la destrucción selectiva de células malignas.
In the last years, different strategies have been developed to specifically destroy cancer cells minimizing side effects on healthy ones. One of these strategies is photodynamic therapy (PDT), a technique that uses a photosensitizer (PS) in combination with a specific wavelength in the presence of oxygen. When the PS is excited, reactive oxygen species (ROS) are produced, which would kill the surrounding cells. To selectively direct PSs to target cells, they can be attached to drug carries, like nano- and microparticles (NPs and µPs, respectively). In this way, biofunctionalizing NPs or µPs with PSs and molecules able to recognize malignant cells would improve cell targeting, increasing the effectivity of PDT. Another strategy to destroy malignant cells is the use of other therapeutic drugs that interact with intracellular targets to kill the cell. These drugs can also be carried by NPs or µPs to improve cell targeting, but the main limitation of this approach is their entrapment in the endolysosomal compartment after internalization by cells. To overcome this problem, escape enhancing strategies have been developed, like photochemical internalization (PCI), which is based in the same principles as PDT, but in this case the PS must accumulate in the endolysosomal membranes. In this way, disruption of the endolysomal membranes after PS excitation would allow the release of the endocytosed cargo. The aim of the present thesis is to contribute in the development of the aforementioned strategies for the selective destruction of malignant cells. In the first work, photodynamic treatments with two PSs (Na-H2TCPP and its zinc derivative Na-ZnTCPP) were found to induce a decrease in cell survival in both tumoral (SKBR3) and non-tumoral (MCF10A) cells, though the latter showed higher resistance at low PSs concentrations. Moreover, different cell death mechanisms were triggered depending on both the PS and the cell line, a result that could be exploited to selectively protect non-malignant cells in photodynamic treatments. In a second work, HER2 was found to be a suitable target to direct anti-HER2 biofunctionalized µPs to a tumorigenic cell line overexpressing this receptor. We also demonstrated that different culture conditions (monoculture or coculture in static or microfluidics systems) influenced µPs internalization, emphasising the importance of performing in vitro studies on cells- µPs interactions in an environment more similar to in vivo conditions (cocultures in microfluidic systems). Finally, in our third work, we found that PCI effectively induces endolysosomal membrane disruption, allowing the release of soluble molecules into the cytosol, but not complete membrane disintegration, which would be needed for the release of entrapped µPs. In conclusion, the present thesis provides new knowledge towards the development of better therapeutic agents and treatments based on the use of PSs and µPs for the selective destruction of malignant cells.
Howie, Andrew Gordon, and howie andrew@gmail com. "Improving high dose rate and pulsed dose rate prostate brachytherapy - alternative prostate definition and treatment delivery verification methods." RMIT University. Applied Sciences, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091007.091553.
Повний текст джерелаTrpkova, Biljana. "Posterior-anterior cephalometric assessment of adolescents with TMJ internal derangement." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28994.pdf.
Повний текст джерелаWilliamson, Philip Charles. "Condyle angulation and position associated with adolescent TMJ disc status." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/MQ28999.pdf.
Повний текст джерелаAguiar, Leidiane Marques de. "Programa de desenvolvimento educacional/PDE/PR: formação tecnológica de professores da rede estadual, um estudo de caso." Universidade Estadual do Oeste do Parana, 2016. http://tede.unioeste.br:8080/tede/handle/tede/2436.
Повний текст джерелаThis research has as its theme the technological training of basic education teachers of the State schools, provided by the Educational Development Program - PDE / PR. We aim to initially understand how the technological training process is given during evidenced training and how the courses offered and the engagement with the Digital Communication Technology (DCT) during this continuing training enable important reflections and actions in the act of educating of the participating teachers. This research is supported, among others, in the following question: What are the contributions that the actions/activities of the program shaft, Didactic and pedagogical activities with the use of technological support, offered for the teachers training as meaning to prepare them for their new role, in view the use of technology in the educational context of Aprendência (teaching learning process)? To this end, based on theoretical assumptions, initially we approach the relationship between Experimentation, Rhizome, Education and Technology, the view to problematize a teaching still out of step the reality of our students, who are browsing at constant speeds through the computerization of knowledge. In order to problematize a teaching still out of step the reality of our students, who are browsing at constant speeds through the computerization of knowledge. We still carry on about the importance of teachers continuing training in the twenty-first century context, in order to provide a rhizome teaching, respecting the multiplicities and providing more cooperative, emancipatory and meaningful learning. Methodologically, this research follows the paths of Applied Linguistics, it is supported by the qualitative approach and is characterized by the case study under interpretative approach. The research has as theoretical support the ideas of the authors: Gilles Deleuze (2006, 2003, 2001, 1996, 1995), Félix Guattari (1996, 1995), Michel Authier (1995), Pierre Lévy (2000, 1999a, 1999b, 1995, 1993), Hugo Assmann (2012, 2001, 2000), Edgar Morin (2003, 2000), Araci Hack Capatan (2001), Marc Prensky (2001), Beatriz Helena Dal Molin (2003), Manuel Castells (1999), Silvio Gallo (2008, 2002), Gilson Fais (2011), Dóris Roncarelli (2012), José Rogério Vitkowski (2014), Rose Maria Belim Motter (2013), Teresa Cristina Jordão (2009), among others. We checked during the research, that the PDE program is the way of fundamental public policy allowing the necessary involvement of the participating teachers in several theories, methodologies and in contact with the technology through its third shaft. However, we found when analyzing the speeches generated based on questions proposed to the participants, that the program still has challenges to be overcome, such as to allow the teachers who attend the PDE, epistemological reflections on the process of teaching and learning with the use of Digital Communication Technology.
A presente pesquisa tem como tema a formação tecnológica de professores da Rede Estadual de ensino da Educação Básica, proporcionada pelo Programa de Desenvolvimento Educacional PDE/PR. Objetivamos, inicialmente, compreender como se dá o processo de formação tecnológica durante a formação evidenciada e como os cursos oferecidos e o envolvimento com a Tecnologia de Comunicação Digital (TCD) durante essa formação continuada possibilitam importantes reflexões e ações no fazer educativo dos professores participantes. Esta pesquisa sustenta-se, entre outras, na seguinte indagação: Quais as contribuições que as ações/atividades do eixo do programa, Atividades didático-pedagógicas com utilização de suporte tecnológico, ofereceram para a formação do docente no sentido de prepará-lo para seu novo papel, frente ao emprego da tecnologia no contexto educativo da Aprendência? Para tanto, a partir dos pressupostos teóricos, abordamos inicialmente a relação entre Experimentação, Rizoma, Educação e Tecnologia, a vista de problematizar um ensino ainda em descompasso da realidade de nosso educandos, que estão navegando a velocidades constantes por meio da informatização do saber. Ocupamo-nos ainda em discorrer sobre a importância de formação continuada de professores em contexto de século XXI, com o objetivo de proporcionar um ensino rizomático, respeitando as multiplicidades e proporcionando aprendizagens mais cooperativas, emancipatórias e significativas. Metodologicamente, esta pesquisa segue pelos caminhos da Linguística Aplicada, sustentada pela abordagem qualitativa e caracterizada pelo estudo de caso, sob a abordagem interpretativista. A pesquisa traz como aporte teórico as ideias dos autores: Gilles Deleuze (2006, 2003, 2001, 1996, 1995); Félix Guattari (1996,1995); Michel Authier (1995); Pierre Lévy (2000, 1999a, 1999b, 1995, 1993); Hugo Assmann (2012, 2001, 2000); Edgar Morin (2003, 2000); Araci Hack Capatan (2001); Marc Prensky (2001); Beatriz Helena Dal Molin (2003); Manuel Castells (1999); Silvio Gallo (2008, 2002); Gilson Fais (2011); Dóris Roncarelli (2012); José Rogério Vitkowski (2014); Rose Maria Belim Motter (2013); Teresa Cristina Jordão (2009); entre outros. Verificamos, no decorrer da pesquisa, que o programa PDE é via de política pública fundamental para a formação em tempos de TCD, possibilitando o necessário envolvimento dos professores participantes, em várias teorias, metodologias e no contato com a tecnologia por meio do seu terceiro eixo. Entretanto, constatamos, ao analisar os discursos gerados a partir dos questionamentos propostos aos participantes, que o programa ainda apresenta desafios a serem superados, como é o caso de possibilitar aos professores que cursam o PDE, reflexões epistemológicas sobre o processo de ensinar e de aprender com o emprego da Tecnologia de Comunicação Digital
Meshkati, Farhad. "Chip equalization and transmit antenna diversity for high-speed SS/TDM systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63022.pdf.
Повний текст джерелаSturaro, Giulio. "Attività antiproliferativa di derivati furocumarinici attivati da blue light in linee cellulari di carcinoma prostatico e vescicale." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425396.
Повний текст джерелаIl carcinoma protatico e quello vescicale sono le patologie tumorali a maggiore incidenza con i più alti tassi di mortalità. Quest’ultima è connessa all’elevata frequenza di ricadute derivante da una scarsa efficacia dei trattamenti disponibili, spesso caratterizzati da invasività e tossicità. Un nuovo approccio potrebbe essere rappresentato dalla fotochemioterapia nella quale i farmaci vengono attivati per svolgere la loro funzione direttamente sul sito interessato, riducendo quindi la tossicità alle cellule sane limitrofe. L’attività antiproliferativa dei composti usati, psoraleni ed angelicine in associazione con luce UVA, è ben nota ed in gran parte dovuta alla loro capacità di interagire con il DNA formando monoaddotti (MA) e legami crociati (XL). Tuttavia, il maggior svantaggio è rappresentato dal rischio di mutagenicità legato sia alla loro capacità di legare covalentemente l’acido nucleico che alla tossicità della stessa radiazione utilizzata. La possibilità di fotoattivare questo tipo di molecole con blue light (BL) potrebbe rappresentare un’innovazione nel campo della fotochemioterapia poichè BL, diversamente da UVA, possiede una più profonda penetrazione tessutale, permettendo quindi il potenziale trattamento di tumori più invasivi, e al contempo presenta una minore mutagenicità. In questa tesi è stato dimostrato che 8-MOP e TMA, nonostante i loro bassi coefficienti di estinzione molare, sono in grado di essere fotoattivate da BL ed esercitano un effetto antiproliferativo su linee cellulari di tumore prostatico (DU145) e vescicale (T24). Esperimenti su DNA isolato hanno confermato la capacità di queste molecole di formare MA e XL, produrre tagli ai filamenti e fotoossidare le basi dell’acido nucleico quando attivate da UVA; la fotoattivazione mediante BL induceva, invece, sia una diminuzione quantitativa che una variazione nella tipologia delle lesioni alla macromolecola. Questa diminuzione risultava di gran lunga maggiore nel caso di TMA che, al contrario di 8-MOP, in seguito ad attivazione con BL non era in grado di formare XL e di fotoossidare il DNA. L’ attività antiproliferativa di 8-MOP e TMA risultava dall’induzione del processo apoptotico e dalla formazione di ROS. Inoltre, veniva modulato lo stato di attivazione di p38 ed ERK1/2 con entrambe le tipologie di irradiazione. Tuttavia, i dati raccolti hanno evidenziato che TMA possedeva una maggiore efficacia rispetto a 8-MOP essendo attiva a dosi minori. Inoltre, non era genotossica, come mostrato dalla valutazione dello stato di fosforilazione dell’istone H2AX sia nelle cellule DU145 che nelle T24, quando irradiata con UVA o BL. TMA/BL, inoltre, modulava in modo negativo la via di segnale canonica di Wnt; aumentava le forme fosforilate di β-catenina e di GSK3β (tirosina 216) e diminuiva i livelli nucleari di β-catenina. L’inibizione di questa via si traduceva nella diminuzione dell’espressione di ciclina D1, c-Myc e CD44 nella sua variante v6, come evidenziato dalla RT-PCR; per quest’ultima si registrava anche una riduzione dell’espressione proteica. L’inibizione della via Wnt era dovuta alla modulazione dello stato di fosforilazione di GSK3β, come suggerito dal parziale recupero dell’espressione di β-catenina nucleare ed alla riduzione della sua forma fosforilata in seguito a trattamento con LiCl. I dati raccolti hanno suggerito, inoltre, che lo stato di attivazione di GSK3β potesse essere mediato da ERK1/2, in quanto TMA/BL induceva una diminuzione della sua forma fosforilata. In conclusione, TMA fotoattivata da BL può rappresentare un’interessante opzione per la fotochemioterapia dei carcinomi prostatico e vescicale non invasivo, in quanto tale trattamento è in grado di inibire vie chiave per la crescita e la progressione tumorale in assenza di effetti genotossici.
Tilley, Aleceia Marie. "Comparison study of the states of Washington and Oregon's total maximum daily load (TMDL) process." Online pdf file accessible through the World Wide Web, 2007. http://archives.evergreen.edu/masterstheses/Accession86-10MES/Tilley_A%20MESThesis%202007.pdf.
Повний текст джерелаEnglish, Luke D. "A discussion of the 3D geometry, ascent and emplacement mechanisms for the Anabama granite, South Australia using TMI data, geochemistry and core logs /." Adelaide, 2002. http://web4.library.adelaide.edu.au/theses/09SB/09sbe578.pdf.
Повний текст джерелаRego, Raquel Ferreira. "Estudo comparativo de precursores da PpIX (ALA e MAL) utilizados topicamente em terapia fotodinâmica." Universidade Federal de São Carlos, 2008. https://repositorio.ufscar.br/handle/ufscar/6945.
Повний текст джерелаUniversidade Federal de Sao Carlos
Photodynamic therapy (PDT) is a modality for treatment of tumors, and uses a combination of a drug (photosensitizer) and light in the presence of the molecular oxygen to selectively damage target tissue. In the absent of one of these components, the cytotoxic effect is not observed. Since 1990, many works in the literature studies the topical application of precursors of protoporphyrin IX (PpIX) in PDT, such 5- aminolevulinic acid (ALA) and methyl aminolevulinate (MAL). The purpose of this work was realized an comparative study in vivo between two commercial and available drugs precursors of PpIX, the ALAsense (5-aminolevulinic acid - ALA) from Russian and Metvix (methyl aminolevulinate MAL) from United Kingdom. Experiments were carried out in animals to analyze the performance and the ALA photodynamic MAL in liver of rats. The fluorescence spectra of the liver were collected at pre-determined time. The time of accumulation of PpIX was observed by 2 hours and 45 minutes for the ALA and MAL for 4 hours after application of drugs in the liver. The formation, accumulation and depth of penetration of PpIX in liver tissue were determined by fluorescence spectroscopy. Using a total of 21 animals were the irradiation of the liver fotossensibilizado with ALA or MAL alone with different doses of light (20, 50, 100 and 200J/cm2) or in a combination MAL + ALA to 8%, 16% and 32 dose of 100J/cm2. Thirty hours after the lighting, the animals were killed and livers removed. The area of necrosis of the liver was assessed macroscopically and the samples were prepared for histological study, considering especially the aspects and depth of necrosis. In histological analysis were carried out many aspects of necrosis and the normal liver. The depths of necrosis were measured and the threshold dose obtained using a mathematical model proposed in the literature. Moreover, the monitoring was carried out of O2 consumption of mitochondria isolated from livers of rats, after topical administration of drugs precursors of PpIX (ALA and MAL) in order to check the influence of these substances in mitochondrial bioenergetics. The results showed a higher penetration of MAL in the tissue, as well as greater depth of necrosis when compared to the ALA. These results suggest that MAL has a tendency to better photodynamic response than ALA to the criteria studied.
Terapia Fotodinâmica (TFD) é uma modalidade terapêutica para tratamento de tumores que provoca a destruição do tecido alvo através da combinação de uma droga (fotossensibilizador) e uma fonte de luz na presença de oxigênio molecular. Na ausência de algum desses componentes, o efeito citotóxico não é observado. Desde 1990, têm-se estudado a aplicação tópica de substâncias precursoras da protoporfirina IX (PpIX) associada à TFD, como o ácido 5-aminolevulínico (ALA) e o metil aminolevulinato (MAL). O objetivo do presente trabalho foi realizar um estudo comparativo in vivo entre duas substâncias precursoras da PpIX , o ALAsense (ácido 5-aminolevulínico - ALA) da Rússia e o Metvix (metil aminolevulinato MAL) do Reino Unido. Foram realizados experimentos em animais para analisar o desempenho fotodinâmico ALA e pelo MAL em fígado de ratos. Os espectros de fluorescência do fígado foram coletados em tempos prédeterminados. O tempo de acúmulo da PpIX observado foi de 2 horas e 45 minutos para o ALA e 4 horas para o MAL após a aplicação da droga no fígado. A formação, acúmulo e a profundidade de penetração da PpIX no tecido hepático foram determinados através da espectroscopia de fluorescência. Utilizando um total de 21 animais foi realizada a irradiação do fígado fotossensibilizado com ALA ou com MAL isoladamente com diferentes doses de luz (20, 50, 100 e 200J/cm2) ou na forma combinada MAL + ALA a 8%, 16 e 32% com dose de 100J/cm2. Trinta horas após a iluminação, os animais foram mortos e os fígados removidos. A área necrosada do fígado foi avaliada macroscopicamente e as amostras foram preparadas para o estudo histológico, considerando, principalmente, os aspectos e a profundidade da necrose. Na análise histológica realizada foram observados vários aspectos da necrose e da região normal do fígado. As profundidades de necrose foram medidas e a dose limiar obtida utilizando-se um modelo matemático proposto na literatura. Além disso, foi realizado o monitoramento do consumo de O2 de mitocôndrias isoladas de fígados de ratos, após administração tópica dos medicamentos precursores da PpIX (ALA e MAL) afim de verificar a influência dessas substâncias na bioenergética mitocondrial. Os resultados obtidos mostraram uma maior penetrabilidade do MAL no tecido, bem como uma maior profundidade de necrose quando comparado ao ALA. Esses resultados sugerem que o MAL possui uma tendência a melhor resposta fotodinâmica que o ALA para os critérios estudados.
Rego, Raquel Ferreira. "Estudo histomorfométrico da necrose em tecido hepático de ratos: terapia fotodinâmica combinada com ablação a laser e terapia fotodinâmica com o fotossensibilizador Luzitin®." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/264.
Повний текст джерелаUniversidade Federal de Sao Carlos
Photodynamic Therapy (PDT) is known to be limited to applications in large volume tumours due to its limited penetration. Therefore, the PDT with the Luzitin® photossensitizer as well as a combination of PDT and laser surgery may constitute a potential to destroy bulk tumors. Thus, with the aim of proposing a minimally invasive treatment protocol involving the application of PDT for large tumors, the present study analyzed histomorphometrically necrosis resulting from both a combination of a laser ablation with PDT as PDT with the photosensitizer Luzitin® (a bacteriochloryn synthetic with greater potential for penetration into biological tissue) in livers of healthy rats. In the first study, 87 animals were divided into 2 groups: CO2 laser and diode laser. Each of these groups were subdivided into six subgroups: 1) only laser ablation, 2) administered the PS and ablated with laser, 3) only PDT (drug and ligth), 4) drug and light (PDT) followed by laser ablation, 5) ) laser ablation followed by a PDT and 6) drug, followed by laser ablation and ligth. For each subgroup, three types of photosensitization were used: topical 5- aminilevunic acid (ALA), intravenous ALA and intravenous Photogem®. Thirty hours after the different treatments, the animals were sacrificed and the livers removed for the histological and morphometric study of necrosis. The results showed that the effects of treatment were considerably improved when PDT was used in combination with laser ablation. For the group CO2 laser, the average depth of necrosis obtained showed a minimum difference between the studied conditions for the group photosensitized Photogem® and with an increased depth of necrosis after the combined procedures in comparison with the isolated techniques for the subgroups fotossensibilizados with ALA, especially treatment with PDT was performed before ablation by CO2 laser. In the diode laser group, subgroups with better performance were those in which the ablation was performed before PDT using intravenous photosensitizers and ALA topic. From these results, it is suggested that PDT and laser ablation can synergistically in the treatment of large tumors. In the second study, sixteen normal male rats were randomly divided into 4 groups with 4 animals each. Initially, all groups were intravenously photosensitizated with 2 mg/kg or 2.6 mg/kg of the drug and after 12 hours, a 1cm2 of area, in the right abdominal region, corresponding to the liver, was irradiated during 22 minutes and 13 seconds or16 minutes and 40 seconds. Groups are described following: 1) control group: photosensitized with 2mg/kg, but untreated, 2) treated group 1: irradiated with light dose of 100J/cm2 after photosensitization with 2mg/kg of 12hs and 3) treated group 2: irradiated with light dose of 70J/cm2 and photosensitized with 2mg/kg of Luzitin®, 4) treated group 3: photosensitized with 2.6 mg/kg of the drug and irradiated with light dose of 70J/cm2 Animals were sacrificed 30 hours after irradiation, except the control group, which were sacrificed 42hs after drug administration. Livers were removed and prepared for histological analysis. Moreover, macroscopic aspects of liver were observed. Results showed significantly more extensive necrosis and greater severity in treated group 1. Data suggested that, among the conditions studied, light dose suitable for PDT treatment of photosensitized tissue by Luzitin® is 100J/cm2 and that 30% of reduction in this value produces decay in PDT response, even with proportional increase of drug concentration in the organism.
A terapia fotodinâmica (TFD) é uma técnica conhecida por sua limitada aplicação em tumores volumosos, devido a sua restrita penetração. Portanto, a TFD com o fotossensibilizador (FS) Luzitin®, bem como a combinação da TFD com a cirurgia a laser possuem potencial destrutivo para tumores volumosos. Assim, com o intuito de propor um protocolo de tratamento minimamente invasivo envolvendo a TFD para aplicação em tumores volumosos, o presente estudo analisou histomorfometricamente a necrose resultante tanto da combinação de lasers ablativos com a TFD, quanto da TFD com o fotossensibilizador Luzitin® (uma bacterioclorina sintética com maior potencial para penetração nos tecidos biológicos) em fígados de ratos saudáveis. No primeiro estudo, 87 animais foram divididos em 2 grupos: grupo laser de CO2 e grupo laser de Diodo. Cada um desses grupos foram subdivididos em 6 subgrupos: 1) subgrupo ablação a laser, 2) subgrupo fotossensibilização seguida de ablação a laser, 3) subgrupo TFD, 4) subgrupo fotossensibilização e luz seguido pela ablação a laser, 5) subgrupo laser seguido de fotossensibilização e luz, e 6) subgrupo fotossensibilização seguida da ablação a laser e luz. Para cada subgrupo, três condições de fotossensibilização foram utilizadas: ácido 5-aminolevulínico (ALA) tópico, ALA endovenoso e Photogem® endovenoso. Trinta horas após o tratamento, os animais foram eutanasiados e os fígados removidos para estudo histológico e morfométrico da necrose. Os resultados mostram que os efeitos do tratamento com TFD foram consideravelmente melhorados quando combinada com a ablação a laser. Para o grupo laser de CO2, a profundidade de necrose média obtida mostrou uma mínima diferença entre as condições estudadas para o grupo fotossensibilizado com o Photogem® e um aumento da profundidade de necrose após os procedimentos combinados em comparação com as técnicas isoladas para os subgrupos fotossensibilizados com o ALA, especialmente qunado o tratamento com a TFD foi realizado antes da ablação pelo laser de CO2. No grupo laser de Diodo, os subgrupos com melhor desempenho foram aqueles em que a ablação foi realizada antes da TFD para os fotossensibilizadores intravenosos e o subgrupo fotossensibilizado com ALA tópico, ablacionado e iluminado. A partir desses resultados, sugere-se que a TFD e a ablação a laser podem atuar de forma sinérgica no tratamento de tumores volumosos. No segundo estudo, dezesseis ratos machos normais foram randomicamente divididos em 4 grupos, com 4 animais cada. Inicialmente foi realizada a fotossensibilização por meio da administração intravenosa de 2mg/kg ou 2,6mg/kg da droga e após 12 horas, uma área de 1cm2 na região abdominal direita correspondente ao fígado foi irradiada durante 22 minutos e 13 segundo ou 16 minutos e 40 segundos. Os grupos estão descritos a seguir: 1) grupos controle: fotossensibilizado com 2mg/kg, porém não tratado; 2) grupo tratado 1: irradiado com intensidade de 100J/cm2 após 12hs da fotossensibilização com 2mg/kg; 3) grupo tratado 2: irradiado com intensidade de 70J/cm2 e fotossensibilizados com 2mg/kg de Luzitin®, 4) grupo tratado 3: fotossensibilizado com 2,6mg/kg da droga e irradiado com intensidade de 70J/cm2 Os animais foram eutanasiados após 30 horas da irradiação, exceto o grupo controle, que foram aguardadas 42hs após a administração do composto. Os fígados dos animais foram removidos e preparados para a análise histológica. Além disso, foram observados aspectos macroscópicos do fígado. A análise dos resultados mostrou uma necrose significativamente mais extensa e com maior grau de severidade para o grupo tratado 1. Com base nos dados observados, sugere-se que, dentre as condições estudadas, a dose mais adequada para o tratamento com TFD do tecido fotossensibilizado com Luzitin® seja de 100J/cm2 e que uma redução de 30% desse valor provoca um decaimento na resposta da TFD, mesmo com aumento proporcional da concentração da droga no organismo.
Anet, Neto Luiz. "Étude des potentialités des techniques de modulation multiporteuse pour les futurs réseaux d'accès optique WDM et TDM PON." Limoges, 2012. http://aurore.unilim.fr/theses/nxfile/default/cab79f38-79d8-4a40-b758-d014d6d0ee3e/blobholder:0/2012LIMO4021.pdf.
Повний текст джерелаMalgré son succès dans le domaine des radio-fréquences, l’OFDM n’a que récemment commencé à attirer l’attention de la communauté optique grâce à une remarquable évolution de l’électronique et aux demandes de débit de plus en plus élévées dans les réseaux d’accès. OFDM apparaît comme un très fort candidat pour fournir la flexibilité tant attendue dans les réseaux d’accès optiques "rigides" d’aujourd’hui ayant aussi le potentiel de permettre une évolution vers des débits, portées et nombre d’abonnés plus élévés. Dans cette thèse, nous nous concentrons sur une approche de modulation en intensité et détection directe (IMDD) qui permet de conserver la simplicité sur le plan optique en transférant la complexité de la transmission au domaine du traitement numérique du signal. Ce travail se base sur deux axes principaux. Dans le premier, nous étudions l’influence de la réponse fréquentielle du canal, caracterisée par l’interaction entre la dispersion chromatique de la fibre optique et la modulation parasite en phase provenant de la source optique et les moyens d’optimiser le débit du système avec des algorithmes d’allocation de puissance et modulation. Deuxièmement, nous évaluons l’approche IMDD OFDM sous différentes architectures et techniques de partage des ressources du réseau entre les abonnées, à savoir les multiplexages en temps, longueur d’onde et fréquence
Santos, Nayra Fernandes. "Relação entre estresse oxidativo fotoinduzido e morte celular autofágica." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01102014-090745/.
Повний текст джерелаPhotodynamic Therapy (PDT) is a promising therapeutic modality that has shown effective clinical outcomes and benefits in terms of costs to the national health system. Although PDT is associated with induction of cell death by necrosis or apoptosis, recent data suggest the activation of autophagy. In order to understand the relationship between reactive oxygen species (ROS), generated after light activation of photosensitizers (PSs), and the autophagic cell death induction, we have used two phenothiazines with similar structure - methylene blue (MB) and 1,9-dimethyl methylene blue (DMMB); HaCaT and HeLa cells were used as biological models and LEDs emitting at 633 nm were used as light source. Cell viability assays as function of light dose and PS concentration showed that the increase in cell death was directly proportional to the PS concentration and light dose, to the both PSs. At IC50 was verified that DMMB concentration (10 nmol/L) is lower than MB concentration (2,0 µmol/L) in two order of magnitude, and this difference is reflected in degree of oxidative stress promoted by photosensitizers . Only for MB the amount of detected ROS is highly correlated with loss of cell viability, while for DMMB this correlation is weak, because there is loss of viability without large generation of ROS. Nevertheless, the viability decreased for DMMB is highly correlated with the increase of autophagy, indicating occurrence of autophagic cell death in both HaCaT cells and in HeLa cells. The analyses of damaged cell organelles indicated that both PSs, after be photoactivated, induce lysosomal and mithochondrial damage in HaCaT cells. And the subcellular localization assay confirmed that DMMB and MB are localized in these organelles. Because the subcellular localization of PSs influences cell death mechanisms, this research identified that MB, in the same nanomolar concentration of DMMB, does not induce autophagy, because it is photochemically inactive in mitochondria due the reducing coenzymes present in this organelle. DMMB has a lower reduction potential than MB, which hinders PS reduction in mitochondria, and possibly generate a mild oxidative stress that compromise the integrity of mitochondria and lysosomes, and justify autophagy induction as a cell death mechanism. The conditions that MB is not fully reduced in the cellular environment are at higher concentrations, in which was detected high level of oxidative stress and autophagic cell death was not observed after photosensitization. These results show that the efficiency of cell death induced by PDT is not necessarily related with oxidative stress level, since the oxidative stress induced by DMMB was lesser than by MB, however, the cell death was greater. This research confirms the concept that more effective photosensitizers for PDT means greater specificity of photosensitization reactions, and not only improvement of the efficiency of ROS generation.
Boudjarane, Mohamed. "Etude observationnelle sur les domaines cognitifs, neurosensoriels et comportementaux de deux populations d'enfants avec des Troubles Envahissants du Développement." Thesis, Brest, 2018. http://www.theses.fr/2018BRES0007.
Повний текст джерелаThe purpose of this work is to observe the potential effects of new treatment in children with Pervasive Developmental Disorders. For this, we compared two groups of children with PDD, one being treated the other constituting a control group, across domains of cognition, sensory and behaviors of daily life and socialization. We collected different tools for our methodology: parental questionnaires, psychometric assessments and psychophysical assessments. We also used a comparative approach for the sensory domain integrating a typical child development group.The results of this work highlight that whole of the evaluated behaviors did not appear altered in our population of children with PDD. We pointed out increased improvements in treated children regarding their visuospatial abilities. We also found that these children had improvements in some verbal processes. We confirmed the presence of particular patterns of sensory behavior in children with PDD compared to the typically developed population.However, we did not show any difference in evolution of these sensory alterations between our two groups of children with PDD. Finally, repeated and restricted behaviors appeared to be more alleviated in treated PDD children than control PDD children but we did not confirm the improvements in social behaviors reported by previous studies. This study has brought results that need to be scrutinized in more detail, on a larger scale
Pires, Layla. "Optical strategies for diagnosis and treatment of melanoma." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-01122017-154608/.
Повний текст джерелаO melanoma é um tumor pigmentado que surge dos melanócitos, células pigmentadas presentes em todo o corpo, incluindo a pele e a íris. A forma cutânea é a mais comum e representa cerca de 5% dos tumores cutâneos diagnosticados no Brasil. Embora não tenha uma alta incidência, representa cerca de 80% a 85% de todas as mortes por tumor de pele. O segundo tipo de melanoma mais frequente é o ocular. Representa 5% de todos os casos de melanoma e é uma doença potencialmente letal, especialmente em casos de metástase. A principal abordagem terapêutica para melanomas, em geral, é a cirurgia, com ressecção da lesão cutânea ou enucleação no caso do melanoma ocular. Outras técnicas, como imunoterapia adjuvante, quimioterapia paliativa e radioterapia também são usadas, porém, apresentam baixa eficiência e muitos efeitos colaterais. A terapia fotodinâmica é uma modalidade terapêutica baseada na interação da luz em um comprimento de onda específico e um fotossensibilizador, na presença de oxigênio molecular, levando a célula à morte. Como o melanoma é um câncer pigmentado, geralmente não responde bem à terapia fotodinâmica devido à alta absorção de luz na superfície do tumor, impossibilitando a erradicação volumétrica. Este projeto investigou estratégias ópticas para o diagnóstico e tratamento do melanoma. Para o diagnóstico, foi avaliada a técnica de tempo de vida de fluorescência para distinguir melanoma de pele normal. Utilizando análise de discriminação linear, obteve-se uma sensibilidade de 99,4%, especificidade de 97,4% e precisão de 98,4%. Para o tratamento de melanoma cutâneo, a PDT combinada com clareadores ópticos (OCAs) foi investigada. Um fotossensibilizador que tem como alvo vaso sanguíneo e um fotossensibilizador de alvo celular foram avaliados combinados ou não com OCAs. OCAs são soluções hiperosmóticas que desidratam o tecido, diminuindo o espalhamento da luz e melhorando a penetração de luz em profundidade. OCA melhorou a resposta de PDT em todos os tumores melanóticos tratados, mas os melhores resultados foram obtidos quando a PDT foi realizada com a combinação dos fotossensibilizadores e clareador óptico em uma única sessão. O tratamento do melanoma conjuntival foi realizado utilizando a terapia fotodinâmica por excitação de 2 fótons (TPE-PDT). A vantagem desta técnica é o uso de luz na região do infravermelho, em um comprimento de onda que melanina tem baixa absorção, melhorando a penetração de luz no tumor. A histologia do tumor mostrou que a apoptose foi induzida apenas no local do tratamento, sem danos no tecido adjacente. Além disso, uma única sessão de TPE-PDT foi capaz de tratar todo o tumor.
Swasey, Christel Lane. "Ethnographic Literary Journalism." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd3087.pdf.
Повний текст джерелаGalvis, Gloria Esneida Castrillon. "(Des)encuentros del profesor con la alteridad del alumno de la educación especial y la construcción de um acogimiento : transitando entre textualidades, gestos y contornos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/104490.
Повний текст джерелаPublic policies about special education, the different teaching techniques and the offerings of teacher’s training, hardly address the subject of alterity. Training courses focused in re-education, in diagnostics and already-made orientations about what and how-to do, do not take into account the impasses that come from an encounter with a student read as uncanny; from the paralyzation of the teacher upon the presence of an individual that seems not to learn, not to associate with other, not to be. How does the teacher embrace the student’s alterity? Hard work is necessary in this matter. In this research, we propose ourselves to think this duty as a journey able to reposition the teacher by means of words upon her student with Pervasive Developmental Disorder (PDD). For that end, we will take as empirical field a continued teacher training (I and II stages) between 2012 and 2013, in the city of Porto Alegre, located in the state of Rio Grande do Sul, Brazil. In such training, the teachers were invited to read what they lived and turn that into experience through writing, while being accompanied by a reader, through annotations and comments on a side of what was written. The texts that set up this research deal with the (dis)encounters among three teachers that participated in the training, related with the inclusion of students with PDD in the school. This is an exploratory study with a methodology that contemplates the essay as form. The argumentative tissue is built considering the film called Spirited Away, the Freudian concept of the uncanny and the concept of reading proposed by Barthes. As results we can note: the narrative construction, about a student that initially produces silence and discomfort, allows important disruptions in the declarative position and in the pedagogic practice of the teachers; the potential of the alterity as something that has to be considered in teacher training, policies, and the implementation of inclusive processes; in the collaborative work that considers embracing the student and the teacher, as well, in her fears and uncertainty.
Las políticas públicas de educación especial, las diversas didácticas y las ofertas de formación de profesores, difícilmente se ocupan de la temática de la alteridad. Cursos formativos centrados en la reeducación, en el conocimiento diagnóstico y en orientaciones acabadas sobre qué y cómo hacer, no contemplan los impases oriundos de un encuentro con un alumno leído como ominoso; de la paralización del profesor ante la presencia de un sujeto que parece no aprender, no relacionarse, no estar. ¿Cómo el profesor acoge la alteridad del alumno? Es preciso un arduo trabajo en este sentido. En esta pesquisa, nos proponemos a pensar tal trabajo como una travesía capaz de reposicionar discursivamente al profesor ante su alumno con Trastornos Generalizados del Desarrollo (TGD). Para ello, tomaremos como campo empírico una formación continuada de profesores en sus I y II módulo, ocurrida entre los años 2012 y 2013, en el municipio de Porto Alegre, situado en el estado de Rio Grande del Sur en Brasil. En dicha formación, el profesor fue convidado a leer lo vivido y tornarlo experiencia a través de su escritura. Siendo acompañado de un lector, a través de notas y comentarios al margen del escrito. Las textualidades constitutivas de esta pesquisa dan cuenta de los (des)encuentros entre tres profesores participantes del curso, relacionados con la inclusión escolar de alumnos con TGD. Se trata de un estudio exploratorio cuya metodología contempla el ensayo como forma. El tejido argumentativo es construido considerando el largometraje: El Viaje de Chihiro, el concepto freudiano de lo ominoso y la conceptualización de lectura de Barthes. Como resultados destacamos: la construcción narrativa, sobre un alumno que inicialmente produce silencio y malestar, permite dislocamientos importantes en la posición enunciativa y en la práctica pedagógica de los profesores; la potencia de la alteridad como temática a ser contemplada en la formación de profesores, en las políticas y en la implementación de los procesos inclusivos; el trabajo en red que contempla el acogimiento del alumno y también del profesor, en sus temores e incerteza.
Cai, Bonnie Bao Yan. "Sex-related differences in the suppressive effects of peripheral morphine but not GABA on reflex jaw muscle activity evoked by glutamate application to the TMJ region in rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58880.pdf.
Повний текст джерелаPanier, Sylvain. "Conception des circuits de polarisation des détecteurs et de maintien de la tension de base du LabPET II." Mémoire, Université de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/5293.
Повний текст джерелаBrisot-Dubois, Judith. "Troubles Envahissants du Développement Sans Déficience Intellectuelle : Facteurs Prédictifs de la reconnaissance des expressions faciales émotionnelles." Thesis, Montpellier 3, 2011. http://www.theses.fr/2011MON30083/document.
Повний текст джерелаFacial emotionanl expression recognition in Pervasive Developpemental Disorders (PDD) are atypic and contribute to social skills difficulties for children and adolescents with PDD, including without intellectual disabilities. Hypothesis: predictiv factors exist in facial emotional expression recognition in PDD. Objectives: 1) characterize the abilities of facial emotional expressions recognition of 32 children and adolescents; 2) identify risk or protective factors in the development of these abilities. Compare our results with a control group of 37 typical peers. Our study is cross-sectional, descriptive and analytical. The primary point was the number of errors in the Danva 2F, which is a validated and standardized assessment tool (basic emotional expression). Results: show that our clinical group made significantly more errors in the recognition of facial emotional expressions than what is observed in population and standardized in our control population. Risk factors of the number of errors made in the Danva are highlighted: the intensity of socio-communicative disorders present as measured by the ADOS (ORa=2,08 ; IC 95%= [1,02/4,22] ; p=0,006). Protective factors are identified, linked to a low of stereotyped and repetitive patterns score below the threshold of the area 3 of the ADI (DANVA AF: ORa=0,078 ; IC 95%= [0,007/0,883] ; p=0,02. DANVA CF: ORa: 0,05 ; IC 95%= [0,005/0,44] ; p=0,0004). Conclusion: results allow us to observe a disorder of the ability to recognize facial expressions in our clinical group and the presence of risk factors and protective factors related to it. Perspectives: use a larger sample to study clinical parameters more related to emotional processing, our clinical work emphasizes the importance of early intervention multimodal, to improve the capacity of emotional processing
Boisjoly, Dominic. "Sélection de l'habitat par le coyote, Canis latrans, dans le contexte de la conservation du caribou de la Gaspésie." Thèse, [Rimouski, Québec] : Université du Québec à Rimouski, 2007. http://bibvir.uqac.ca/bd/man.cfm?TD=ARC&IdNot=000339967&FORMAT=pdf.
Повний текст джерелаTitre de l'écran-titre (visionné le 20 juin 2007). Mémoire présenté à l'Université du Québec à Rimouski comme exigence partielle du programme de maîtrise en gestion de la faune et de ses habitats. Comprend un résumé. CaQRU CaQRU CaQRU Comprend des bibliogr. Parait aussi en éd. imprimée. CaQRU
Walid, Abdelrahman. "4G LTE : eMBMS with MBSFN Service Simulation using OPNET." Thesis, Mittuniversitetet, Avdelningen för informations- och kommunikationssystem, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24208.
Повний текст джерелаMarques, David Alexandre Quaresma de Morais. "Sistema de multiplexagem para tributários síncronos e assíncronos." Master's thesis, 2000. http://hdl.handle.net/10773/26139.
Повний текст джерелаThis document describes a prototype system architecture for the simultaneous transport of synchronous (PDH) and asynchronous (Ethernet) traffic through a single communication channel. The work here described covered a magnitude of areas, from system supported interfaces related problems, through system dimensioning and architecture issues, until detailed implementations of all fundamental system units. A fully digital solution for system implementation is presented, as well as the used system architecture. This implementation, based on digital technology, allows the use of this system in different transport medium channels. Special attention is taken with the detailed implementation of large part of this system, including those modules responsible for fundamental functions that improve system performance. The proposed architecture has been materialised in two programmable logic devices (CPLD) - based circuit able to transparently transport PDH and Ethernet signals. An extra auxiliary channel for specific control purposes was additionally desirable, and has been initially included in the defined system architecture.
Mestrado em Engenharia Eletrónica e Telecomunicações
Pethuraj, Rajpamal R. "Adaptive resource allocation strategies for dynamic heterogeneous traffic in TD-CDMA/TDD systems." 2006. http://digital.library.okstate.edu/etd/umi-okstate-1819.pdf.
Повний текст джерелаZhang, Biao Fei. "Photoswitching of Bis-Spiropyran Using Upconversion Luminescent Tm3+/Yb3+-Co-Doped Lithium Yttrium Fluoride Nanoparticles." Thesis, 2013. http://spectrum.library.concordia.ca/976948/1/Zhang_MSc_F2013.pdf.
Повний текст джерелаBally, Anne-Sophie. "Structure nominale et expression du temps, du mode et de l'aspect en saramaka : analyse synchronique et diachronique." Thèse, 2011. http://www.archipel.uqam.ca/4050/1/D2165.pdf.
Повний текст джерелаGoudreault, Pénélope. "Étude descriptive corrélationnelle entre le soutien à l'autonomie perçu par les personnes atteintes d'hypertension artérielle et leur motivation à adhérer aux traitements." Thèse, 2020. http://depot-e.uqtr.ca/id/eprint/9511/1/eprint9511.pdf.
Повний текст джерелаDiagne, Elhadji Diaraff Diegane. "Analyse discriminante et perceptron multicouche-liens formels et applications." Thèse, 2019. http://depot-e.uqtr.ca/id/eprint/9412/1/eprint9412.pdf.
Повний текст джерела