Дисертації з теми "TLWs"
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Klasila, A. (Aleksi). "TryTLS:testing TLS libraries." Bachelor's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201712203359.
Повний текст джерелаSalaus on perusrakenneosa yksityisyyden ja turvallisuuden suojaamisessa yhteiskunnassamme, valitettavasti saatamme suoriutua siinä huonosti. TLS:llä (Transport Layer Security) on nykyisin tärkeä osa Internet-liikenteen salaamisessa. SSL (Socket Layer Security) on TLS:n vanhentunut ja vaarallinen edeltäjä. SSL:ää ei pitäisi käyttää enään nykyisin. On olemassa monia protokollia, kuten HTTPS (Hypertext Transfer Protocol Secure), FTPS (File Transfer Protocol with support for TLS) ja IMAP (Internet Message Access Protocol), jotka käyttävät TLS:ää. Lisäksi, kaikilla TLS:ää käyttävillä protokollilla on useita toteutuksia eri ohjelmointikielillä ja kirjastoilla. Tässä työssä tutkitaan kehitettyjä työkaluja TLS-kirjastojen testaamiseen. Tässä työssä tutkitaan myös tunnettuja TLS/SSL-haavoittuvuuksia. Tässä työssä rakennetaan lisäksi järjestelmä TLS:n testaamista varten
McLeary, Alwyn. "Dynamic response of TLPs during tether installation." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394952.
Повний текст джерелаLi, Jiatong. "TLS Library for Isolated Enclaves : Optimizing the performance of TLS libraries for SGX." Thesis, KTH, Kommunikationssystem, CoS, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-241245.
Повний текст джерелаNumera hanterar molnberäkningssystem stora mängder data och bearbetar dessa data över olika system. Det är viktigt att ta itu med datasäkerhetsproblem och dataskydd. Ett sätt att minska säkerhetsproblem är att partitionera koden i olika moduler och sedan isolera kodens exekvering tillsammans med dess data. Intel’s Software Guard Extension (SGX) tillhandahåller säkerhetskritisk kodisolering i en enklav. Genom att isolera kodens körning från en otillförlitlig zon (en oskyddad användarplattform) säkerställs kodintegritet och sekretess. Transport Layer Security (TLS) ansvarar för att ge integritet och konfidentialitet för kommunikation mellan två enheter. Flera TLS-bibliotek stödjer kryptografiska funktioner både för en osäker zon och en enklav. Olika TLS-bibliotek har olika prestanda när de används med Intel’s SGX. Det är önskvärt att använda TLS-bibliotekets bästa prestanda för specifika kryptografiska funktioner. Denna avhandling beskriver en prestationsutvärdering av flera populära TLS-bibliotekens prestanda på Intel SGX. Genom att använda utvärderingsresultaten och kombinera flera olika TLS-bibliotek tillsammans, presenterar avhandlingen en ny design och lösning för att förbättra prestanda för TLS-bibliotek på Intel SGX. Den resulterande prestanda åberopar TLS-bibliotekets bästa prestanda inom en viss datastorlek samtidigt som krypteringsfunktionerna är mångsidiga.
Moore, Mark. "ST2 & TLRs : coordination of chemokine-driven immunity." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/830/.
Повний текст джерелаKassem, Ali. "Toll-like receptors (TLRs) and inflammatory bone modeling." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110296.
Повний текст джерелаVinje, Eivind. "Educational implementation of SSL/TLS." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for datateknikk og informasjonsvitenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-13834.
Повний текст джерелаLevillain, Olivier. "Une étude de l’écosystème TLS." Thesis, Evry, Institut national des télécommunications, 2016. http://www.theses.fr/2016TELE0014/document.
Повний текст джерелаSSL/TLS, a 20-year old security protocol, has become a major component securing network communications, from HTTPS e-commerce and social network sites to Virtual Private Networks, from e-mail protocols to virtually every possible protocol. In the recent years, SSL/TLS has received a lot of attentions, leading to the discovery of many security vulnerabilities, and to protocol improvements. In this thesis, we first explore the SSL/TLS ecosystem at large using IPv4 HTTPS scans, while proposing collection and analysis methodologies to obtain reproducible and comparable results across different measurement campaigns. Beyond these observations, we focused on two key aspects of TLS security: how to mitigate Record Protocol attacks, and how to write safe and efficient parsers. Finally, building on the numerous implementation flaws in almost all TLS stacks in the last years, we propose some thoughts about the challenges in writing a secure TLS library
Cavalieri, Tássio Antonio. "Emprego do MCNP no estudo dos TLDs 600 e 700 visando a implementação da caracterização do feixe de irradiação na instalação de BNCT do IEA-R1." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-19112013-135350/.
Повний текст джерелаBoron Neutron Capture Therapy, BNCT, is a bimodal radiotherapic procedure for cancer treatment. Its usefull energy comes from a nuclear reaction driven by impinging thermal neutron upon Boron 10 atoms. A BNCT research facility has been constructed in IPEN at the IEA-R1 reactor, to develop studies in this area. One of its prime experimental parameter is the beam dosimetry which is nowadays made by using activation foils, for neutron measurements, and TLD 400, for gamma dosimetry. For mixed field dosimetry, the International Commmission on Radiation Units and Measuments, ICRU, recommends the use of pair of detectors with distinct responses to the field components. The TLD 600/ TLD 700 pair meets this criteria, as the amount of 6Li, a nuclide with high thermal neutron cross section, greatily differs in their composition. This work presents a series of experiments and simulations performed in order to implement the mixed field dosimetry based on the use of TLD 600/TLD 700 pair. It also intended to compare this mixed field dosimetric methodology to the one so far used by the BNCT research group of IPEN. The response of all TLDs were studied under irradiations in different irradiation fields and simulations, underwent by MCNP, were run in order to evaluate the dose contribution from each field component. Series of repeated irradiations under pure gamma field and mixed field neutron/gamma field showed differences in the TLD individual responses which led to the adoption of a Normalization Factor. From the use of Normalization Factor the TLD selection it has allowed to overcome TLD selection. TLD responses due to different field components and spectra were studied. It has shown to be possible to evaluate the ralative gamma/neutron fluxes from the relative responses observed in the two Regions of Interest of TLDs glow curves, ROIs, from TLD 600 and TLD 700. It has also been possible to observe the TLD 700 response to neutron, which leads to a gamma dose overstimation when one follows the ICRU recommended mixed field dosimetric procedure. Dose response curves were obtained for the distinct types of TLDs for pure gamma and mixed fields. This work recommends the TLD 600/TLD 700 pair methodology for mixed field dosimetry, this methodology presents a better precision than the one based on TLD 400, however one has to be carefull to avoid gamma dose superestimation.
Sousa, Edi Carlos Pereira de [UNESP]. "Cinética de cristalização em vidros teluritos do sistema TLWN." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/91983.
Повний текст джерелаVidros preparados a partir de massa fundida podem nuclear ou cristalizar novas fases quando são submetidos a tratamentos térmicos acima da temperatura de transição vítrea. Neste traba- lho foram apresentados estudos sobre a cinética de cristalização de vidros teluritos do sistema 80TeO2 –10WO3 –(10–x)Li2 O–xNa2 O, x = 0, 2, 4, 6 e 10% mol, denominado sistema TLWN. As principais teorias sobre nucleação e cristalização de vidros foram detalhadas, tais como: Teoria Clássica de Nucleação, Teoria Clássica de Nucleação Modificada, Teoria de Nucleação Adiabática e Teoria JMAK. Classicamente, o estudo da cristalização de vidros pode ser realizado através da teoria formulada por Johnson–Mehl–Avrami–Kolmogorov (JMAK), a qual descreve os processos de nucleação e cristalização, por intermédio das curvas de calorimetria exploratória diferencial – DSC. Os vidros foram sintetizados pelo método de resfriamento rápido (melt–quenching ). Medidas de DSC foram realizadas a diferentes taxas de aquecimento e com diferentes tama- nhos de partículas para estudar a cinética de cristalização dos vidros. Foi evidenciado o caráter amorfo de alguns vidros e para o vidro TLWN6 foram encontradas diferentes fases cristalinas, tais como: Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α–TeO2 e γ–TeO2 , dispersas na matriz devido aos di- versos tratamentos térmicos realizados em torno das temperaturas correspondentes aos máximos dos picos de cristalização e evidenciadas por DRX. Deconvoluções foram realizadas utilizando funções gaussianas para separar os picos sobrepostos da amostra TLWN6. Ficou evidente, por intermédio da análise dos termogramas, que o número de picos de cristalização aumenta com o incremento do óxido de sódio e também que os vidros teluritos deste sistema não possuem boa estabilidade térmica, quando...
The glasses prepared from the melt mass may crystallize or nuclear new phases when subjected to heat treatment above the glass transition temperature. In this work were presented studies on the kinetics of nucleation and crystallization of glasses tellurite of the system 80TeO2 –10WO3 – (10–x)Li2 O–xNa2 O, x = 0, 2, 4, 6 e 10% mol called TLWN system. The main theories on nucleation and crystallization of glasses have been detailed, such as: Classical Theory of Nucle- ation, Modified Classical Theory of Nucleation, the Nucleation Adiabatic Theory and Theory JMAK. Classically, the study of crystallization of glasses can be performed by theory formu- lated by Johnson–Mehl–Avrami–Kolmogorov (JMAK) which describes processes of nucleation and crystallization through of differential scanning calorimetry curves – DSC. The glasses were synthesized by the method of melt - quenching. DSC measurements were made at different hea- ting rates and with different particle sizes to study the crystallization kinetics of glass. It became evident amorphous character of some glasses and glass TLWN6 different crystalline phases have been found, such as Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α–TeO2 e γ–TeO2 , dispersed in the matrix due to the different heat treatments performed in around the temperatures corresponding to the peak maximum crystallization and evidenced by XRD. Deconvolutions were performed using gaussian functions to separate overlapping peaks TLWN6 sample. It became evident through the examination of thermographs, that the number of peaks of crystallization increases with the increase of sodium oxide and also that this system tellurite glasses do not have good thermal stability when compared to traditional glasses. The activation energies of the crystalline pha- ses were obtained using the... (Complete abstract click electronic access below)
Sousa, Edi Carlos Pereira de. "Cinética de cristalização em vidros teluritos do sistema TLWN /." Ilha Solteira, 2013. http://hdl.handle.net/11449/91983.
Повний текст джерелаBanca: João Carlos Silos Moraes
Banca: Walter Maigon Pontuschka
Resumo: Vidros preparados a partir de massa fundida podem nuclear ou cristalizar novas fases quando são submetidos a tratamentos térmicos acima da temperatura de transição vítrea. Neste traba- lho foram apresentados estudos sobre a cinética de cristalização de vidros teluritos do sistema 80TeO2 -10WO3 -(10-x)Li2 O-xNa2 O, x = 0, 2, 4, 6 e 10% mol, denominado sistema TLWN. As principais teorias sobre nucleação e cristalização de vidros foram detalhadas, tais como: Teoria Clássica de Nucleação, Teoria Clássica de Nucleação Modificada, Teoria de Nucleação Adiabática e Teoria JMAK. Classicamente, o estudo da cristalização de vidros pode ser realizado através da teoria formulada por Johnson-Mehl-Avrami-Kolmogorov (JMAK), a qual descreve os processos de nucleação e cristalização, por intermédio das curvas de calorimetria exploratória diferencial - DSC. Os vidros foram sintetizados pelo método de resfriamento rápido (melt-quenching ). Medidas de DSC foram realizadas a diferentes taxas de aquecimento e com diferentes tama- nhos de partículas para estudar a cinética de cristalização dos vidros. Foi evidenciado o caráter amorfo de alguns vidros e para o vidro TLWN6 foram encontradas diferentes fases cristalinas, tais como: Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α-TeO2 e γ-TeO2 , dispersas na matriz devido aos di- versos tratamentos térmicos realizados em torno das temperaturas correspondentes aos máximos dos picos de cristalização e evidenciadas por DRX. Deconvoluções foram realizadas utilizando funções gaussianas para separar os picos sobrepostos da amostra TLWN6. Ficou evidente, por intermédio da análise dos termogramas, que o número de picos de cristalização aumenta com o incremento do óxido de sódio e também que os vidros teluritos deste sistema não possuem boa estabilidade térmica, quando... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The glasses prepared from the melt mass may crystallize or nuclear new phases when subjected to heat treatment above the glass transition temperature. In this work were presented studies on the kinetics of nucleation and crystallization of glasses tellurite of the system 80TeO2 -10WO3 - (10-x)Li2 O-xNa2 O, x = 0, 2, 4, 6 e 10% mol called TLWN system. The main theories on nucleation and crystallization of glasses have been detailed, such as: Classical Theory of Nucle- ation, Modified Classical Theory of Nucleation, the Nucleation Adiabatic Theory and Theory JMAK. Classically, the study of crystallization of glasses can be performed by theory formu- lated by Johnson-Mehl-Avrami-Kolmogorov (JMAK) which describes processes of nucleation and crystallization through of differential scanning calorimetry curves - DSC. The glasses were synthesized by the method of melt - quenching. DSC measurements were made at different hea- ting rates and with different particle sizes to study the crystallization kinetics of glass. It became evident amorphous character of some glasses and glass TLWN6 different crystalline phases have been found, such as Na2 (TeW2 O9 ), Li2 Te2 O5 , WO3 , α-TeO2 e γ-TeO2 , dispersed in the matrix due to the different heat treatments performed in around the temperatures corresponding to the peak maximum crystallization and evidenced by XRD. Deconvolutions were performed using gaussian functions to separate overlapping peaks TLWN6 sample. It became evident through the examination of thermographs, that the number of peaks of crystallization increases with the increase of sodium oxide and also that this system tellurite glasses do not have good thermal stability when compared to traditional glasses. The activation energies of the crystalline pha- ses were obtained using the... (Complete abstract click electronic access below)
Mestre
Koscielniak, Jan. "Detekce časových postranních kanálů v TLS." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2020. http://www.nusl.cz/ntk/nusl-417261.
Повний текст джерелаNovo, Tiago António Gadim. "Melhoramento da resposta sísmica de edifícios com recurso a TLDs." Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/2335.
Повний текст джерелаSismos ocorridos recentemente têm demonstrado, de forma dramática, que a investigação na área da engenharia sísmica deve ser direccionada para a avaliação da vulnerabilidade das construções, geralmente desprovidas de adequadas características resistentes. O seu esforço deve ser realizado reduzindo a sua vulnerabilidade e, consequentemente, o risco para níveis aceitáveis. O estudo e desenvolvimento de novas técnicas e de materiais de reforço têm um papel fundamental no sentido de evitar perdas económicas e vidas humanas. O trabalho desenvolvido nesta dissertação de mestrado centra-se no estudo de um sistema de protecção sísmica de edifícios, Tuned Liquid Damperes(TLDs), que reduzem as vibrações induzidas pelas acções dinâmicas através de fenómenos de oscilação da superfície livre do fluido (sloshing). Este trabalho foi estruturado em duas partes. Na primeira, estudou-se o comportamento de um Tuned Liquid Damper (TLD) isolado quando sujeito a uma excitação sinusoidal na sua base, com diferentes amplitudes de deslocamento. Na segunda parte deste trabalho avaliou-se a eficiência dos TLDs na melhoria da resposta sísmica de um edifício, com base em análises dinâmicas lineares. O edifício estudado é representativo da arquitectura moderna, localizado em Lisboa. ABSTRACT: Recent earthquakes have dramatically revealed that research in the area of earthquake engineering should be directed towards the evaluation of construction vulnerabilities, which are generally devoid of adequate resistance characteristics. Its reinforcement should be made with a view to reducing its vulnerabilities and consequently, the risk to acceptable levels. The study and development of new reinforcement techniques and/or the improvement of seismic performance is fundamental so as to avoid significant economic losses as well as human lives in future events. The work done in this Master's dissertation is centered on the study of an earthquake protection system, the Tuned Liquid Dampers (TLDs), which can reduce the motions induced by the earthquake's effect on buildings, taking into account the oscillation of the fluid free surface (sloshing). This work was divided into two parts. In the first part, the behavior of an isolated Tuned Liquid Damper (TLD), subjected to a sinusoidal excitation at its base, with different displacement amplitudes was studied. In the second part of this work, the efficiency of the TLDs in improving the seismic response of an existing building was evaluated based on linear dynamic analyses. The building in the study is representative of modern architecture and located in Lisbon.
Lindström, Per, and Oscar Pap. "Mapping the current state of SSL/TLS." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138391.
Повний текст джерелаArmknecht, Jonathan Blake. "A Developer Usability Study of TLS Libraries." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8685.
Повний текст джерелаGeorges, George. "Algorithmes de calcul de positions GNSS basés sur les méthodes des moindres carrés avancées." Thesis, Belfort-Montbéliard, 2016. http://www.theses.fr/2016BELF0298/document.
Повний текст джерелаIn this thesis, the neural approach TLS EXIN was proposed in a new way in order to estimate the position of a GPSreceiver. The general idea of this approach is to develop a more robust method for calculating the position.The ¿pseudorange alone¿ method is one of the simplest techniques and most widely used for estimating the GPSpositioning and it results in solving an overdetermined system of linear equations Ax¿b. In general, the ordinaryleast squares (OLS) and weighted least squares (WLS) are the commonly used methods to estimate the position ofa receiver for their quickness and robustness, but the particular structure of the data matrix A and the noise affectingits entries are not considered. This thesis, instead, aims to address these problems and study the behavior of leastsquares (LS) methods in the presence of a noisy data matrix A.The approach of total least squares (TLS) takes into account the noise in A and b. It is a less robust technique thanOLS and more sensitive to data changes. It is general solved as a direct method. Instead, the neural network TLSEXIN, which is an iterative algorithm (gradient flow) for solving TLS, works better both because it may exploit theinitial condition information derived from the previous epochs, and, in case of null initial conditions, yields anaccurate estimate even in case of close-to-degenerate data matrix.To perform tests between different methods of least squares, two sets of data were collected. The first one comesfrom the TERIA network and includes data collected from different reference stations located throughout France.While the second one is the result of a measurement campaign using GPS (Ublox NL-6002U).Using the real data, a low condition number has been estimated: in this case all LS methods yield equivalentestimates: as a consequence, OLS and WLS are to be preferred for their low computational cost. However, theworst scenario has been investigated which may occur in case of a distant satellite, resulting in the ill-conditioning ofthe GPS problem. This extreme situation justifies the use of the TLS EXIN neural network. The results obtainedconfirm of this approach even for very large condition numbers
Zugárek, Adam. "Hardwarově akcelerovaný přenos dat s využitím TLS protokolu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413087.
Повний текст джерелаHutar, Jan. "Detekce a analýza přenosů využívajících protokoly SSL/TLS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-317032.
Повний текст джерелаDuraes, Fernanda do Valle. "O papel dos receptores do tipo Toll (TLRs) na infecção pelo Schistosoma mansoni." Universidade Federal de Minas Gerais, 2010. http://hdl.handle.net/1843/UCSD-85EQ3N.
Повний текст джерелаRESUMOA esquistossomose é o resultado de uma infecção helmíntica crônica e permanece como importante fator de morbidade em áreas endêmicas tropicais, incluindo o Brasil. Os receptores do tipo toll (TLRs) têm um importante papel no reconhecimento imune inato de patógenos por células dendríticas (DCs) e na indução das respostas adaptativas subseqüentes. Embora já tenha sido demonstrado que TLR2, TLR3 e TLR4 sejam capazes de reconhecer diferentes componentes do Schistosoma in vitro, pouco se sabe sobre o papel desses receptores in vivo. Para a caracterização da resposta imune inata durante a infecção pelo Schistosoma, camundongos selvagens (C57BL/6) e deficientes em MyD88, TLR2 e TLR4 foram infectados com 30 cercárias. Parâmetros parasitológicos como o número de vermes e de ovos no fígado, bem como patológicos - área do granuloma e de fibrose - e imunológicos foram avaliados. Apesar de não terem sido observadas diferenças com relação ao número total de vermes recuperados entre os grupos, os animais TLR2 KO apresentaram uma reduzida fecundidade, com consequente redução do número de ovos depositados no fígado. Entretanto, as maiores alterações foram vistas com relação à resposta imune do hospedeiro. A ausência de MyD88 e de TLR2 resultou em granulomas menores acompanhados da menor produção de CCL11 no tecido hepático desses animais. Além disso, a produção de IL-5 tanto no tecido hepático quanto em esplenócitos de animais MyD88 KO quando re-estimulados com SEA in vitro, estava diminuída, indicando uma redução na resposta Th2. O esquistossômulo é o estágio de vida do Schistosoma mais susceptível ao ataque pelo sistema imune do hospedeiro. Portanto, o papel da resposta imune inata in vitro, num modelo de ativação de células dendríticas pelo tegumento do esquistossômulo (Smteg) foi avaliado. O Smteg foi capaz de ativar as DCs para produzir IL-12 e TNF- e também para aumentar a expressão das moléculas co-estimuladoras CD40 e CD86. Além disso, utilizando DCs derivadas de camundongos deficientes em MyD88, TLR2 e TLR4 nós demonstramos que a habilidade das DCs em produzir IL-12 e TNF- envolve a interação entre o Smteg/ TLR4 e a via de sinalização dependente de MyD88. Em conjunto, esses resultados indicam que o sistema imune inato participa do reconhecimento inicial de componentes do Schistosoma tanto in vitro quanto in vivo. Esse reconhecimento influencia as mudanças patológicas e imunológicas decorrentes da infecção.
Svensson, Pär. "Upgrading the SSL protocol to TLS in the Roxen WebServer." Thesis, Linköping University, Department of Electrical Engineering, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1475.
Повний текст джерелаThe company Roxen Internet Software have an implementation of the secure network protocol SSL (Secure Sockets Layer) which is used in their web server product. This report describes the upgrading of that implementation to the TLS1.0 (Transport Layer Security) standard. It also describes a performance investigation of the SSL/TLS support in the Roxen WebServer and compares it with other common web servers. The initial setup time for the secure SSL/TLS connection was found to be very long in the Roxen Webserver compared to its competitors. The main bottleneck, in the Roxen implementation, was found to be the modular exponentiation that is the core of the RSA decryption algorithm. One suggested improvement is to upgrade the bignumber numerical package used in Roxen WebServer, GMP (The GNU Multiple Precision arithmetic library) from version 2.0 to version 4.0. The newer version of the bignumber package have been measured to have considerably better performance in its modular exponentation operation.
Walsby, Elisabeth Jane. "Role of FUS (TLS) in differentiation in acute myeloid leukaemia." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55540/.
Повний текст джерелаFell, Sérgio George Silva. "Avaliação do desempenho do TLS nas comunicações aeronáuticas via satélite." Instituto Tecnológico de Aeronáutica, 2004. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=623.
Повний текст джерелаKäck, Emil. "TLS Decryption in passive monitoring system with server private key." Thesis, Umeå universitet, Institutionen för datavetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184490.
Повний текст джерелаSilva, Leandro Gustavo da. "Papel dos receptores do tipo Toll (TLRs) na imunopatogênese da malária associada à gravidez." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-21032012-160144/.
Повний текст джерелаPregnancy associated malaria can lead to complications both for the mother and the fetus. Toll like receptors (TLR) TLR2, TLR4 and TLR9 can recognize components of the Plasmodium sp. These receptors signal through the MyD88 protein. However there are few data on TLR in placental malaria. Thus, The objective of this work was to study the role of TLR2, 4, 9 and MyD88 in placental malaria. Among female mice C57BL/6, TLR2-/-, TLR9-/- and MyD88-/-, the lineage MyD88-/- showed higher levels of parasitemia, survival and parental care, and still placentas of MyD88-/- infected female, differently of TLR2-/- and TLR9-/-, had no decrease in the vascular space compared to controls. Animals C57BL/6 infected showed increased mRNA for IL1-b and IL-6 in the placenta, which did not occur in MyD88-/-. Pregnant infected C57BL/6 and MyD88-/- had more splenocytes, with preferential expansion of B lymphocytes (CD19+). in infected C57BL/6 was also demonstrated an increased expression of the activation marker CD69 on CD8+ T lymphocytes. Together, these results suggest that signaling through MyD88 is important for the development of placental malaria and this may be related with an increased inflammatory response induced by the parasite.
Unurkhaan, Esbold. "Secure end-to-end transport over SCTP a new security extension for SCTP /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975686569.
Повний текст джерелаSilva, Fernanda Abujamra da. "Associação da aterosclerose com polimorfismo de TLR2, TLR4, TNF-α e IL-6 e suas expressões em pacientes diabéticos tipo 2." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-23042010-083813/.
Повний текст джерелаType 2 diabetes is an heterogeneous syndrome characterized by the resistance to insulin and/or relative decrease of the secretion of insulin of the pancreatic β cells. T2DM are in high risk of develop atherosclerosis, that is a chronic inflammatory disease involving immune response. Many existing in the atherosclerotics plaques the TLRs are signaling for immune innate response, that activate inflammatory cells involved in progression of atherosclerotic disease. TLRs can be also associated with induction of the resistance to insulin. Many studies have been suggesting that inflammation is a key factor of the progression of atherosclerotic disease in type 2 diabetes. Proinflammatory cytokines, such as IL-6 and TNF-α, are produced by the adipose tissue in high concentration in obese individuals, mainly among patients with T2DM. This study aims to investigate the relationship between TLR2, TLR4, TNF-α and IL-6 gene expression and polymorphisms with T2DM and atherosclerosis. Sixty-one T2DM and thirty nine normoglycemic (control group) individuals were selected at the Coronary Session of the Instituto Dante Pazzanese de Cardiologia (Sao Paulo, Brazil). Carotid artery ultrassonography was used to evaluate the atherosclerotic status. Polymorphisms of TLR4 (Thr399lle), TLR2 (Arg753Gln), and IL6 (-174G>C) genes were detected by PCR-RFLP. TLR4 (Asp299Gly) and TNFA (-308G>A) gene polymorphisms were detected by HRM. Blood leukocytes mRNA expression was measured by real time PCR using GAPD as a reference gene. In T2DM, individuals carrying IL6 -174C allele had higher total cholesterol, VLDL-c and triglycerides than the genotype GG carriers (respectively, p=0,007, p=0,006 and p= 0,030). TLR4 mRNA expression was higher in T2DM than in control individuals (p=0,029). In T2DM group, TNF-α -308GG genotype was associated with increased TNF-α mRNA expression levels (p=0,031) and higher fibrinogen levels than those carrying -308A allele (GA+AA genotypes) (p=0,020). In individuals with atherosclerosis TLR4 299Gly allele was associated with high post-test glucose levels (p=0,012). And carrying IL6 -174C allele had higher total cholesterol and LDL-C than the genotype GG carriers (both p<0,001). The polymorphism -174G>C and the T2DM was related with risk for atherosclerosis (odds ratio respectively: 3,0 and 16,962) and, the male sex and menopause was related with risk for T2DM (odds ratio respectively: 3,401 and 3,025).
Vignudelli, Andrea. "Filtraggio e censura dei servizi Internet Un'analisi sul protocollo SSL/TLS." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13204/.
Повний текст джерелаPetersson, Jakob. "Analysis of Methods for Chained Connections with Mutual Authentication Using TLS." Thesis, Linköpings universitet, Informationskodning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119455.
Повний текст джерелаReimers, Erik. "On the security of TLS and IPsec : Mitigation through physical constraints." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119357.
Повний текст джерелаCedergren, Lucas, and Richard Paakkonen. "En jämförelse mellan TLS och UAV-fotogrammetri : Inmätning av hårdgjorda ytor." Thesis, Uppsala universitet, Byggteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-257679.
Повний текст джерелаMcVeety, Sam. "Secure channel establishment in disadvantaged networks : TLS optimization using intercepting proxies." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61301.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 65-66).
Transport Layer Security (TLS) is a secure communication protocol that is used in many secure electronic applications. In order to establish a TLS connection, a client and server engage in a handshake, which usually involves the transmission of digital certificates. In this thesis we develop a practical speedup of TLS handshakes over bandwidth-constrained, high-latency (i.e. disadvantaged) links by reducing the communication overhead associated with the transmission of digital certificates. This speedup is achieved by deploying two specialized TLS proxies across such links. Working in tandem, one proxy will replace certificate data in packets being sent across the disadvantaged link with a short reference, while the proxy on the other side of the link will restore the certificate data in the packet. The certificate data will be supplied by local or remote caches. Our solution preserves the end-to-end security of TLS and is designed to be transparent to third-party applications, and will thus facilitate rapid deployment by removing the need to modify existing installations of TLS clients and TLS servers. Testing shows that this technique can reduce the overall bandwidth used during a handshake by over 50%, and can reduce the time required to establish a secure channel by over 40% across Iridium links.
by Sam McVeety.
M.Eng.
Gunke, Andreas, and Sven Jany. "Ableitung eines Bergmännischen Risswerks, korreliert aus ALS-, TLS- und RGB-Daten." Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2018. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-237304.
Повний текст джерелаLe, Corf Katy. "La dualité fonctionnelle de la protéine MyD88, dans la signalisation Ras/MAPKs et l'inflammation, conduit à la transformation cellulaire." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10121.
Повний текст джерелаMyD88 is an adaptator protein of the innate immune system, implicated in the défense against microbes. MyD88 is recruited by the Toll-Like Receptors (TLRs) upon there interaction with conserved microbial patterns (PAMPs). Therefore, TLR signaling pathway induces the production of pro-inflammatory cytokines, chemokines and reactive oxygen species. TLRs, via MyD88, form the first line of defense against pathogens. Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion for Ras-mediated carcinogenesis in mice in vivo and for MAPK activation and transformation in vitro. Mechanistically, MyD88 bound to the key MAPK, ERK, and prevented its inactivation by its phosphatase, MKP3, thereby amplifying the activation of the canonical Ras pathway. The relevance of this mechanism to human neoplasia was suggested by the finding that MyD88 was overexpressed and interacted with activated ERK in primary human cancer tissues. Collectively, these results show that in addition to its role in inflammation, MyD88 plays what we believe to be a crucial direct role in Ras signaling, cell-cycle control, and cell transformation
Ihaddadene, Mohand Ameziane. "Numerical modeling of streamer discharges in preparation of the TARANIS space mission." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2040/document.
Повний текст джерелаSprites are large optical phenomena usually produced between 40 and 90 km altitude generally by positive cloud-to-ground lightning (+CG). These are short lifetime phenomena (duration of few milliseconds) that belong to the family of transient luminous events (TLEs) and composed of complex filamentary structures called streamers. Streamers are non-thermal plasma filament, highly collisional, propagating with velocities up to 10⁷ m/s, and characterized with high electric fields at their heads often close to 150 kV/cm when scaled to ground level air. In this work, we have developed a streamer plasma fluid model coupled with an optical emission model to investigate the physics of streamers and sprites in the framework of the TARANIS space mission. TARANIS will observe TLEs from a nadir-viewing geometry along with their related emissions (electromagnetic and particles). In this dissertation, we investigate some mechanisms of emission of energetic radiation from streamers recently proposed in the literature and we present an original spectroscopic method to determine sprite streamers altitudes, velocities, and electric fields through their optical emissions. This method is especially useful for increasing the scientific return of space missions that have adopted nadir-based observation strategies
FILIO, AGUILAR PEDRO DAVID 481858, and AGUILAR PEDRO DAVID FILIO. "Propuesta de inclusión del criptosistema triple des 96en ssl/tls record protocol." Tesis de maestría, Universidad Autónoma del Estado de México, 2014. http://hdl.handle.net/20.500.11799/49976.
Повний текст джерелаDebido a la seguridad requerida al momento de intercambiar información delicada a través de internet, es necesario el uso de algoritmos y protocolos criptográficos complejos como es el caso de Secure Sockets Layer y Transport Layer Security (SSL/TLS), el funcionamiento de éste está dividido en cuatro sub protocolos; Handshake Protocol, Change Cipher Spec Protocol, Alert Protocol y Record Protocol. El presente trabajo de investigación se centra en el SSL/TLS Record Protocol, donde se construye la inclusión del algoritmo Triple DES-96 en la suite de cifrado de SSL/TLS. Con este objetivo, se desarrollan en lenguaje de programación Java los algoritmos Triple DES y Triple DES-96, se realizan pruebas de cifrado y descifrado sobre 1000 archivos de diferentes tipos y tamaños, se mide el tiempo de cada algoritmo en cifrar y descifrar la información, se registran todos los resultados experimentales obtenidos y por último se comparan los resultados. Al descubrir que los resultados son favorables, en disminución de tiempo y mayor robustez en el cifrado, se plantea la inclusión del algoritmo Triple DES-96 en la suite de cifrado SSL/TLS Record Protocol.
CONACYT
Sama, Reddy Ranjith Kumar. "FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/704.
Повний текст джерелаPeresi, Eliana [UNESP]. "Polimorfismo gênico de receptores TLRs e citocinas: papel na resposta imune em pacientes com tuberculose pulmonar." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/101472.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Estadual Paulista (UNESP)
It is estimated that one-third of the total world population is latently infected with M. tuberculosis and only 5-10% of the infected individuals will develop active TB disease during their life-time. The reason why some infected individuals develop active disease, while others do not is not yet entirely understood. Given the central role of TLR-2 in the incitement of inflammation, polymorphisms in its gene might be involved in both infectious and inflammatory diseases. The aim of this study was to evaluate the influence of TLR2 - 16934A/T and GT repeat polymorphisms on the immune response of PTB patients undergoing anti-TB treatment at different time points of anti-tuberculosis treatment: T1 (beginning), T2 (3 months) and T3 (end). For this we genotyped TLR2 -16934 and (GT)n repeats polymorphisms and evaluated the immune response of pulmonary tuberculosis patients during the time of anti-tuberculosis treatment. The present study suggests that TLR2 - 16934A/T and GT repeats polymorphisms can influence differential TLR-2, NF-κB and cytokine levels during anti-TB treatment. We also suggest that PTB patients with TLR2 - 16934 AA genotype may have a worst outcome of the disease, since they have a lower IFN-γ, cytokine essential to initiate the protective immunity to active TB. This association could not be made in our study due to the low number of patients evaluated. Since TLR-2 play a major role in initiating immune response against M. tuberculosis other polymorphisms in TLR2 would be crucial to better understand protective immune responses and may serve as biomarkers of protection or susceptibility to TB
Peresi, Eliana. "Polimorfismo gênico de receptores TLRs e citocinas : papel na resposta imune em pacientes com tuberculose pulmonar /." Botucatu, 2012. http://hdl.handle.net/11449/101472.
Повний текст джерелаCoorientador: Ana Carla Pereira
Coorientador: Edward A. Gravis
Banca: Lenice do Rosário Souza
Banca: Ida Maria Foschiani Dias Baptista
Banca: Fátima Regina Vilani Moreno
Banca: Ana Cláudia Pelizon
Resumo: Não disponível
Abstract: It is estimated that one-third of the total world population is latently infected with M. tuberculosis and only 5-10% of the infected individuals will develop active TB disease during their life-time. The reason why some infected individuals develop active disease, while others do not is not yet entirely understood. Given the central role of TLR-2 in the incitement of inflammation, polymorphisms in its gene might be involved in both infectious and inflammatory diseases. The aim of this study was to evaluate the influence of TLR2 - 16934A/T and GT repeat polymorphisms on the immune response of PTB patients undergoing anti-TB treatment at different time points of anti-tuberculosis treatment: T1 (beginning), T2 (3 months) and T3 (end). For this we genotyped TLR2 -16934 and (GT)n repeats polymorphisms and evaluated the immune response of pulmonary tuberculosis patients during the time of anti-tuberculosis treatment. The present study suggests that TLR2 - 16934A/T and GT repeats polymorphisms can influence differential TLR-2, NF-κB and cytokine levels during anti-TB treatment. We also suggest that PTB patients with TLR2 - 16934 AA genotype may have a worst outcome of the disease, since they have a lower IFN-γ, cytokine essential to initiate the protective immunity to active TB. This association could not be made in our study due to the low number of patients evaluated. Since TLR-2 play a major role in initiating immune response against M. tuberculosis other polymorphisms in TLR2 would be crucial to better understand protective immune responses and may serve as biomarkers of protection or susceptibility to TB
Doutor
Wendlandt, Erik Bruce. "Macrophage microRNA and mRNA responses to stimulation of TLRs or upon infection with Leishmania infantum chagasi." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1416.
Повний текст джерелаLongo, Rosario Alessandro. "Dalla generazione di modelli 3D densi mediante TLS e fotogrammetria alla modellazione BIM." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13284/.
Повний текст джерелаStevanović, Irena 1980. "Characterization of the in vivo functions of PrimPol, a novel TLS primase-polymerase." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/293265.
Повний текст джерелаHemos identificado PrimPol, una proteína no caracterizada que actua in vitro como una polimerasa de bajo procesamiento que es capaz de evitar los dímeros de timina del ADN y que se localiza en el núcleo y en las mitocondrias. Para poder investigar la función de este enzima, hemos generado ratones genetrap y knock out en los cuales se ha abolido la expression de PrimPol. En las células que no expresan PrimPol podemos observar un aumento de la inestabilidad genómica incluso en ausencia de daño, indicando que podría suprimir la expression de sitios frágiles comunes. Tras inducir daño mediante radiación ultravioleta y tratamiento con afidicolina se observó un aumento significativo de aberraciones cromosómicas. En embriones y ratones adultos mediante tinción de LacZ y pudimos ver que PrimPol está altamente expresado en piel y en los ojos en comparación con otros tejidos. La piel dañada con UV en ratones PrimPol-/- mostró una marcada hiperplasia epidérmica en comparación con los ratones salvajes. También hemos observado que en ratones PrimPol-/- de edad avanzada y en ratones jóvenes con lesiones por UV hay un aumento del número de copias de ADN mitocondrial en diferentes tejidos, lo que sugiere que PrimPol podría estar también implicada en la reparación del daño oxidativo. De acuerdo con estos descubrimientos nos planteamos la hipótesis de que PrimPol pueda actuar como una translesion polimerasa que puede saltarse grandes lesiones inducidas por UV y especies reactivas de oxígeno y así promover la integridad del ADN nuclear y mitocondrial además de un normal envejecimiento.
Rascão, Madalena da Silva Ruivo Coreixas. "Aquisição de dados LiDAR com TLS e HMLS para deteção de árvores individuais." Master's thesis, ISA, 2019. http://hdl.handle.net/10400.5/21291.
Повний текст джерелаLiDAR (Light Detection And Ranging) é um sistema baseado nos princípios de Deteção Remota que permite medir distâncias com base no tempo da trajetória da radiação laser, desde que é emitida pelo aparelho até que retorna ao recetor depois de ser refletida numa superfície sólida. A aplicabilidade deste sistema é abrangente a várias áreas da engenharia e prende-se com a capacidade que o mesmo tem de recolher e armazenar dados tridimensionais em forma de nuvens de pontos de qualquer objeto sólido sobre a superfície terrestre. No sector florestal, este sistema permite estimar características dos povoamentos e digitalizar uma extensa área de floresta, de uma forma automatizada, rápida e com detalhe na ordem dos milímetros. O objetivo do presente trabalho é avaliar a capacidade do sistema LiDAR na individualização da árvore comparando as coordenadas estimadas obtidas com dois métodos LiDAR - HMLS (Held-Hand Mobile Laser Scanner) e TLS (Terrestrial Taser Scanner) - com as coordenadas obtidas com GPS sub-métrico, pelo método tradicional de campo, num ensaio clonal de Eucalyptus globulus Labill. com 10 anos de idade. O presente estudo serviu também como primeira abordagem ao desempenho dos dois métodos LiDAR na obtenção de diâmetros às várias alturas do tronco, recorrendo aos algoritmos disponíveis no software R. Para a deteção das árvores individuais, os resultados demonstraram que, em média, o método TLS detetou 65,1% das árvores, enquanto o método HMLS detetou 44,7% das árvores, para todas as parcelas de estudo. Comprovou-se ainda que o levantamento com HMLS só é vantajoso para terrenos regulares e percursos retos. Concluiu-se que deve ser efetuada uma melhoria nos processos associados à utilização do algoritmo SLAM (Simultaneous Localization And Mapping) e salientou-se a importância de utilizar pontos de referência em campo para a obtenção de nuvens de pontos de melhor qualidade
N/A
Sun, Yanshen. "Evaluating the quality of ground surfaces generated from Terrestrial Laser Scanning (TLS) data." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/90577.
Повний текст джерелаMaster of Science
Elevation is one of the most basic data for researches such as flood prediction and land planning in the field of geography, agriculture, forestry, etc. The most common elevation data that could be downloaded from the internet were acquired from field measurements or satellites. However, the finest grained of that kind of data is 1/3m and errors can be introduced by ground objects such as trees and buildings. To acquire more accurate and pure-ground elevation data (also called Digital Terrain Models (DTM)), Researchers and GIS analysts introduced laser scanners for small area geographical research. For land surface data collection, researchers usually fly a drone with laser scanner (ALS) to derive the data underneath, which could be blocked by ground objects. An alternative way is to place the laser scanner on a tripod on the ground (TLS), which provides more data for ground morphological features under dense tree canopies and better precision. As ALS and TLS collect data from different perspectives, the coverage of a ground area can be different. As most of the ground extraction algorithm were designed for ALS data, their performance on TLS data hasn’t been fully tested yet. Our research area was a 100m by 140m region of grass, weeds and small trees along Strouble’s Creek on the Virginia Tech campus. Four popular ground filter tools (ArcGIS, LASTools, PDAL, MCC) were applied to both ALS and TLS data. The output ground point clouds were then compared with a ground surface generated from ALS data of the same region. Among the four ground filter tools employed in this research, the distances from TLS ground points to the ALS ground surface were no more than 0.06m with standard deviations less than 0.3m. The results indicated that the differences between the ground extracted from TLS and that extracted from ALS were subtle. The conclusion is that Digital Terrain Models (DTM) generated from TLS data are valid.
NESREEN, HAMAD ABDELGAWWAD HAMAD. "Structural analysis of the interaction between FUS/TLS protein and non-coding RNA." Kyoto University, 2020. http://hdl.handle.net/2433/259065.
Повний текст джерелаONeill, Mark Thomas. "The State of Man-in-the-Middle TLS Proxies: Prevalence and User Attitudes." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6180.
Повний текст джерелаSatterwhite, Christopher R. "Development of CPANEL, An Unstructured Panel Code, Using a Modified TLS Velocity Formulation." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1472.
Повний текст джерелаMuniz, Rafael Oliveira Rondon. "Desenvolvimento de um simulador antropomórfico para simulação e medidas de dose e fluxo de nêutrons na instalação para estudos em BNCT." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-15082011-082735/.
Повний текст джерелаIPEN facility for researches in BNCT (Boron Neutron Capture Therapy) uses IEA-R1 reactor\'s irradiation channel number 3, where there is a mixed radiation field neutrons and gamma. The researches in progress require the radiation fields, in the position of the irradiation of sample, to have in its composition maximized thermal neutrons component and minimized, fast and epithermal neutron flux and gamma radiation. This work was developed with the objective of evaluating whether the present radiation field in the facility is suitable for BNCT researches. In order to achieve this objective, a methodology for the dosimetry of thermal neutrons and gamma radiation in mixed fields of high doses, which was not available in IPEN, was implemented in the Center of Nuclear Engineering of IPEN, by using thermoluminescent dosimeters TLDs 400, 600 and 700. For the measurements of thermal and epithermal neutron flux, activation detectors of gold were used applying the cadmium ratio technique. A cylindrical phantom composed by acrylic discs was developed and tested in the facility and the DOT 3.5. computational code was used in order to obtain theoretical values of neutron flux and the dose along phantom. In the position corresponding to about half the length of the cylinder of the phantom, the following values were obtained: thermal neutron flux (2,52 ± 0,06).108n/cm2s, epithermal neutron flux (6,17 ± 0,26).107.106n/cm2s, absorbed dose due to thermal neutrons (4,2 ± 1,8)Gy and (10,1 ± 1,3)Gy due to gamma radiation. The obtained values show that the fluxes of thermal and epithermal neutrons flux are appropriate for studies in BNCT, however, the dose due to gamma radiation is high, indicating that the facility should be improved.
Perego, Jessica. "Modulation pharmacologique des voies de signalisation des TLRs par le Guanabenz, un inhibiteur de la réponse au stress." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4066.
Повний текст джерелаSustained immune reaction is strictly interconnected to pathogenic situations. For this reason, the activation of immune cells is controlled by multiple pathways. A cross-talk between microbial sensing and Endoplasmic Reticulum (ER) homeostasis has been discovered. Abnormal accumulation of proteins in the ER is a sign of cellular malfunction and triggers emergency rescue pathways, collectively known as the Unfolded Protein Response (UPR). UPR induction triggers or amplifies inflammatory signals by dendritic cells (DCs). GADD34/PP1 is a holophosphatase complex that dephosphorylates eIF2α and participates in the UPR feedback loop, by restoring protein translation. It has been shown that GADD34 plays an important role in controlling the expression of pro-inflammatory cytokines, especially type I interferon. In dendritic cells (DCs), pathogens are sensed by Pathogen Recognition Receptors (PRRs); the better characterised class of PRRs being the Toll-Like Receptors (TLRs). Thus, the aim of my thesis is to investigate how TLRs and ER-signalling pathways intersect and how this can be used to control pathogenic states, with particular attention for the GADD34/PP1 complex. Using both human and mouse DCs, we show that guanabenz (GBZ), an inhibitor of the GADD34/PP1 complex, blocks endosomal TLRs activation. The same inhibitor rescues mice viability in a TLR-dependent septic shock model and controls the circulating autoantibodies in a lupus model. Our studies show that TLR9 is particularly sensitive to GBZ. We show also that GBZ has a previously unidentified effect on CH25H, an enzyme that hydroxylates the cholesterol in 25-hydroxycholesterol, recently linked to TLRs signaling
Frenzel, Laurent. "Régulations épigénétiques et rôles de la protéine Btk dans l'expression du TNF-α par la voie des TLRs". Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01071591.
Повний текст джерелаMobit, Paul Njom. "Monte Carlo and experimental studies of dose measurement in radiotherapy with LiF-TLDs and other solid state dosemeters." Thesis, Institute of Cancer Research (University Of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244763.
Повний текст джерелаMoretti, Isabele Fattori. "Receptor do tipo Toll 4 dentre os TLRs de membrana plasmática possui um papel na malignidade de astrocitomas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-05122018-131346/.
Повний текст джерелаToll-like receptors (TLRs) are the first to identify disturbances in the immune system, recognizing pathogens such as bacteria, fungi, and viruses. Since the inflammation process plays an important role in several diseases, TLRs have been considered potential therapeutic targets, including treatment for cancer. However, TLRs\' role in cancer remains ambiguous. This study aims to analyze the expression levels of plasmatic cell membrane TLRs (TLR1, TLR2, TLR4, TLR5, and TLR6) in different grades (II-IV) of human astrocytoma, the most prevalent tumor of CNS. We demonstrated that TLR expressions were higher in astrocytoma samples compared to non-neoplastic brain tissue, by qRT-PCR. The genes and proteins expressions were observed in U87MG and A172 GBM cell lines, proving their presence in the tumor cells. Associated expressions between the known heterodimers TLR1-TLR2 were found in diffusely infiltrative astrocytoma. In GBM, the mesenchymal subtype showed higher levels of TLR expressions in relation to classical and proneural subtypes. Aiming to indentify the role of TLRs in tumor cells, we chose the highest TLR expressed in GBM cells, the TLR4, and performed functional assays stimulating U87MG-GBM cell line with LPS, a natural agonist for TLR4. The proliferation rate was similar in treated and non-treated cell with LPS. However, NF-kB activation was detected after 12hrs of LPS stimulation. When TLR4 signaling pathway was inhibited by a chemical compound (VGX-1027) a decrease in the proliferation rate was observed. Additionally, in silico analysis revealed a strong association of TLRs upregulation with increased expression level of genes related to cell cycle, inflammasome and ripoptosome pathways, further highlighting TLRs as interesting targets for cancer complementary treatment