Статті в журналах: "Tissue application"

1

Feng, Wei, Yoke San Wong, and Dietmar W. Hutmacher. "The Application of Image Processing Software for Tissue Engineering(Cellular & Tissue Engineering)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2004.1 (2004): 95–96. http://dx.doi.org/10.1299/jsmeapbio.2004.1.95.

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2

Jing, D., Y. Yi, W. Luo, S. Zhang, Q. Yuan, J. Wang, E. Lachika, Z. Zhao, and H. Zhao. "Tissue Clearing and Its Application to Bone and Dental Tissues." Journal of Dental Research 98, no. 6 (April 22, 2019): 621–31. http://dx.doi.org/10.1177/0022034519844510.

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Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Many tissue-clearing methods have been developed, and they all follow similar working principles. During the tissue-clearing process, chemical or physical treatments are applied to remove components blocking or scattering the light. Finally, samples are immersed in a designated clearing medium to achieve a uniform refractive index and to gain transparency. Once the transparency is reached, images can be acquired even at several millimeters of depth with high resolution. Tissue clearing has become an essential tool for neuroscientists to investigate the neural connectome or to analyze spatial information of various types of brain cells. Other than neural science research, tissue-clearing techniques also have applications for bone research. Several methods have been developed for clearing bones. Clearing treatment enables 3-dimensional imaging of bones without sectioning and provides important new insights that are difficult or impossible to acquire with conventional approaches. Application of tissue-clearing technique on dental research remains limited. This review will provide an overview of the recent literature related to the methods and application of various tissue-clearing methods. The following aspects will be covered: general principles for the tissue-clearing technique, current available methods for clearing bones and teeth, general principles of 3-dimensional imaging acquisition and data processing, applications of tissue clearing on studying biological processes within bones and teeth, and future directions for 3-dimensional imaging.

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3

Hollander, J. E., and A. J. Singer. "Application of tissue adhesives." Plastic Surgical Nursing 19, no. 4 (1999): 209. http://dx.doi.org/10.1097/00006527-199919040-00011.

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4

Un, Umran Tezcan, Seher Topal, Emre Oduncu, and Ulker Bakir Ogutveren. "Treatment of Tissue Paper Wastewater: Application of Electro-Fenton Method." International Journal of Environmental Science and Development 6, no. 6 (2015): 415–18. http://dx.doi.org/10.7763/ijesd.2015.v6.628.

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5

Dhandayuthapani, Brahatheeswaran, Yasuhiko Yoshida, Toru Maekawa, and D. Sakthi Kumar. "Polymeric Scaffolds in Tissue Engineering Application: A Review." International Journal of Polymer Science 2011 (2011): 1–19. http://dx.doi.org/10.1155/2011/290602.

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Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

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6

Pascoal-Faria, Paula, Pedro Castelo Ferreira, Abhishek Datta, Sandra Amado, Carla Moura, and Nuno Alves. "Electrical Stimulation Optimization in Bioreactors for Tissue Engineering Applications." Applied Mechanics and Materials 890 (April 2019): 314–23. http://dx.doi.org/10.4028/www.scientific.net/amm.890.314.

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We review here the current research status on bioreactors for tissue engineering with cell electrical stimulation. Depending on the cell types, electrical stimulation has distinct objectives, in particular being employed both to mimic and enhance the endogenous electricity measured in the natural regeneration of living organisms as well as to mimic strain working conditions for contractible tissues (for instance muscle and cardiac tissues). Understanding the distinct parameters involved in electrical stimulation is crucial to optimize its application. The results presented in the literature and reviewed here reveal that the application of electrical stimulation can be essential for tissue engineering applications.

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7

Borrella-Andrés, Sergio, Miguel Malo-Urriés, Albert Pérez-Bellmunt, José L. Arias-Buría, Jacobo Rodríguez-Sanz, María Isabel Albarova-Corral, Vanessa González-Rueda, Gracia M. Gallego-Sendarrubias, César Fernández-de-las-Peñas, and Carlos López-de-Celis. "Application of Percutaneous Needle Electrolysis Does Not Elicit Temperature Changes: An In Vitro Cadaveric Study." International Journal of Environmental Research and Public Health 19, no. 23 (November 26, 2022): 15738. http://dx.doi.org/10.3390/ijerph192315738.

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Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this intervention is a potential thermal effect. The aim of this study was to investigate if the application of PNE induces changes in temperature in different cadaveric musculoskeletal tissues. A repeated measure experimental cadaveric study was designed with 10 cryopreserved knees (5 men, 5 women). Sterile stainless-steel needles of 40 mm length and 0.30 mm caliber were used in this study. An ultrasound-guided needling puncture was performed in the targeted tissue (patellar tendon, infra-patellar fat, and vastus medialis muscle). Additionally, the tip of the needle was placed next to the thermometer sensor at the minimum possible distance without direct contact with it. The temperature differences before and after different applications were measured. The applications were: three applications for 3 s of 3 mA of intensity (3:3:3) when the tendon was the targeted tissue, three applications for 3 s of 1.5 mA of intensity (1.5:3:3) when the fat or muscle was the targeted tissue, and 24 s of 1 mA of intensity (1:24:1) in all tissues. No statistically significant Group*Time interactions were found in any tissue (tendon: F = 0.571, p = 0.459, ŋ2 = 0.03; fat pad: F = 0.093; p = 0.764, ŋ2 = 0.01; muscle: F = 0.681; p = 0.420, ŋ2 = 0.04). Overall, no changes in temperature were observed between both applications in the tendon (3:3:3 vs. 1:24:1) and fat/muscle (1.5:3:3 vs. 1:24:1) tissues. The application of two different percutaneous needle electrolysis protocols did not produce appreciable thermal changes in the tendon, fat, and muscle tissues of human cadavers. The results from the current cadaver study support that a thermal effect should not be considered as a mechanism of clinical action regardless of the targeted human tissue when applying percutaneous needle electrolysis since no changes in temperature after its application were observed.

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8

Best, Cameron, Ekene Onwuka, Victoria Pepper, Malik Sams, Jake Breuer, and Christopher Breuer. "Cardiovascular Tissue Engineering: Preclinical Validation to Bedside Application." Physiology 31, no. 1 (January 2016): 7–15. http://dx.doi.org/10.1152/physiol.00018.2015.

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Advancements in biomaterial science and available cell sources have spurred the translation of tissue-engineering technology to the bedside, addressing the pressing clinical demands for replacement cardiovascular tissues. Here, the in vivo status of tissue-engineered blood vessels, heart valves, and myocardium is briefly reviewed, illustrating progress toward a tissue-engineered heart for clinical use.

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9

TORII, Takahiro, Mitsuo MIYAZAWA, and Isamu KOYAMA. "Application of Shear Stress to Tissue Engineering." Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 28, no. 2 (2003): 168–70. http://dx.doi.org/10.4030/jjcs1979.28.2_168.

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10

Varghese, Dr Mekha Grace, Dr Thomas George V., Dr Nebu George Thomas, Dr Alenya Mary Pyas, and Dr Arimboor Maymol Francis. "Marine Based Biomaterials in Dental Regeneration." International Journal of Innovative Research in Medical Science 5, no. 10 (October 3, 2020): 443–48. http://dx.doi.org/10.23958/ijirms/vol05-i10/965.

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The novel approach of tissue engineering aims at regenerating the functional alveolar or periodontal tissues through a series of key events that is modulated by the use of scaffolds, cells and signalling molecules. Many synthetic and natural polymers have been used as tissue engineering constructs so far with varying results in regeneration. Developing a biomaterial to replace the damaged tissue is of paramount importance for effective regeneration. Due to its rich biodiversity, marine environment yields structures with immense potential for biomedical application. These bio molecules offer many applications in cartilage and bone tissue engineering, dental tissue regeneration, wound healing and local drug delivery system. These substances are usually nontoxic, bio compatible and well tolerated by the body, which boost their efficacy for tissue engineering application. In this article, we are trying to brief the various marine based biomaterials used in dental regeneration, their possible sources and clinical applications.

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11

Holt, Timothy L., and Fred A. Mann. "Soft tissue application of lasers." Veterinary Clinics of North America: Small Animal Practice 32, no. 3 (May 2002): 569–99. http://dx.doi.org/10.1016/s0195-5616(02)00006-2.

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12

Swenson, Randal W. "Tissue expansion: Technique and application." Operative Techniques in Otolaryngology-Head and Neck Surgery 4, no. 1 (March 1993): 61–64. http://dx.doi.org/10.1016/s1043-1810(10)80108-3.

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13

Davis, Judi E., and Sophie Cordeaux. "Tissue adhesive: use and application." Emergency Nurse 2, no. 2 (August 1994): 16–18. http://dx.doi.org/10.7748/en.2.2.16.s4.

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14

Lee, Jung-Hwan, and Seog-Jin Seo. "Biomedical Application of Dental Tissue-Derived Induced Pluripotent Stem Cells." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/9762465.

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The academic researches and clinical applications in recent years found interest in induced pluripotent stem cells (iPSCs-) based regenerative medicine due to their pluripotency able to differentiate into any cell types in the body without using embryo. However, it is limited in generating iPSCs from adult somatic cells and use of these cells due to the low stem cell potency and donor site morbidity. In biomedical applications, particularly, dental tissue-derived iPSCs have been getting attention as a type of alternative sources for regenerating damaged tissues due to high potential of stem cell characteristics, easy accessibility and attainment, and their ectomesenchymal origin, which allow them to have potential for nerve, vessel, and dental tissue regeneration. This paper will cover the overview of dental tissue-derived iPSCs and their application with their advantages and drawbacks.

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15

JIANG, XINGSHAN, SHUANGMU ZHUO, and JIANXIN CHEN. "DIAGNOSTIC APPLICATION OF MULTIPHOTON MICROSCOPY IN EPITHELIAL TISSUES." Journal of Innovative Optical Health Sciences 04, no. 02 (April 2011): 159–63. http://dx.doi.org/10.1142/s179354581100137x.

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Epithelial cancer comprises more than 85% of human cancers. The detection and treatment at the early stage has been demonstrated to apparently improve patient survival. In this review, we summarize our recent research works on the diagnostic application of epithelial tissue based on multiphoton microscopy (MPM), including identification of the layered structures of esophagus, oral cavity, skin and bronchus tissues, establishment of the diagnostic features for distinguishing gastric normal tissue from cancerous tissue, linking collagen alteration and ectocervical epithelial tumor progression for evaluating epithelial tumor progression, and differentiating normal, inflammatory, and dysplastic ectocervical epithelial tissues. These results provide the groundwork for developing MPM into clinical multiphoton endoscopy.

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16

Grove, Christina, Oliver Peschel, and Andreas G. Nerlich. "A Systematic Approach to the Application of Soft Tissue Histopathology in Paleopathology." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/631465.

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The application of histology to soft tissue remains offers an important technique to obtain diagnostically important information on various physiological and pathological conditions in paleopathology. In a series of 29 cases with mummified tissue ranging between 16 months and c. 5.200 years of postmortem time interval, we systematically investigated paleohistology and the preservation of various tissues. We established a reproducible histological ranking system for the evaluation of mummified tissue preservation. The application of this scheme to the series showed good tissue preservation of tissues with high connective tissue content but also fat tissue and connective tissue rich organs, such as lung tissue, while most other internal organs were less well preserved despite highly different postmortem time intervals. There are some organs with only poor conservation even in short term periods such as the kidneys and CNS. Artificial mummification does not provide better conservation than naturally mummified tissues; “cold” mummies may be much better conserved than those from desert areas. The identification of specific pathologies underlines the potential power of paleohistology.

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17

Jiang, Wei, Haiying Mei, and Shuyan Zhao. "Applications of 3D Bio-Printing in Tissue Engineering and Biomedicine." Journal of Biomedical Nanotechnology 17, no. 6 (June 1, 2021): 989–1006. http://dx.doi.org/10.1166/jbn.2021.3078.

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In recent years, 3D bio-printing technology has developed rapidly and become an advanced bio-manufacturing technology. At present, 3D bio-printing technology has been explored in the fields of tissue engineering, drug testing and screening, regenerative medicine and clinical disease research and has achieved many research results. Among them, the application of 3D bio-printing technology in tissue engineering has been widely concerned by researchers, and it contributing many breakthroughs in the preparation of tissue engineering scaffolds. In the future, it is possible to print fully functional tissues or organs by using 3D bio-printing technology which exhibiting great potential development prospects in th applications of organ transplantation and human body implants. It is expected to solve thebiomedical problems of organ shortage and repair of damaged tissues and organs. Besides,3Dbio-printing technology will benefit human beings in more fields. Therefore, this paper reviews the current applications, research progresses and limitations of 3D bio-printing technology in biomedical and life sciences, and discusses the main printing strategies of 3D bio-printing technology. And, the research emphases, possible development trends and suggestions of the application of 3D bio-printing are summarized to provide references for the application research of 3D bio-printing.

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18

Hamano, Sayuri, Risa Sugiura, Daiki Yamashita, Atsushi Tomokiyo, Daigaku Hasegawa, and Hidefumi Maeda. "Current Application of iPS Cells in the Dental Tissue Regeneration." Biomedicines 10, no. 12 (December 16, 2022): 3269. http://dx.doi.org/10.3390/biomedicines10123269.

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When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been established from various dental tissues for dental tissue regeneration. This review describes the regeneration of dental tissue using iPS cells. It is important to mimic the process of tooth development in dental tissue regeneration using iPS cells. Although iPS cells had safety issues in clinical applications, they have been overcome in recent years. Dental tissue regeneration using iPS cells has not yet been established, but it is expected in the future.

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19

Xi, Lei. "Research Progress of the Application of Hypothermia in the Eye." Oxidative Medicine and Cellular Longevity 2020 (December 15, 2020): 1–13. http://dx.doi.org/10.1155/2020/3897168.

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Hypothermia is widely used in the medical field to protect organs or tissues from damage. Different research fields have different explanations of the protection mechanism of hypothermia. Hypothermia is also widely used in the field of ophthalmology, for example, in the eye bank, the preservation of corneal tissue and the preservation of the eyeball. Low temperature can also be applied to some ophthalmic diseases, such as allergic conjunctivitis, retinal ischemia, and retinal hypoxia. It is used to relieve eye symptoms or reduce tissue damage. Hypothermic techniques have important applications in ophthalmic surgery, such as corneal refractive surgery, vitrectomy surgery, and ciliary body cryotherapy for end-stage glaucoma. Hypothermia can reduce the inflammation of the cornea and protect the retinal tissue. The eyeball is a complex organ, including collagen tissue of the eyeball wall and retinal nerve tissue and retinal blood vessels. The mechanism of low temperature protecting eye tissue is complicated. It is important to understand the mechanism of hypothermia and its applications in ophthalmology. This review introduces the mechanism of hypothermia and its application in the eye banks, eye diseases (allergic conjunctivitis, retinal ischemia, and hypoxia), and eye surgeries (corneal transplant surgery, corneal refractive surgery, and vitrectomy).

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20

Kleinhenz, Matthew D., Jiwan P. Palta, Christopher C. Gunter, and Keith A. Kelling. "Impact of Source and Timing of Calcium and Nitrogen Applications on `Atlantic' Potato Tuber Calcium Concentrations and Internal Quality." Journal of the American Society for Horticultural Science 124, no. 5 (September 1999): 498–506. http://dx.doi.org/10.21273/jashs.124.5.498.

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Three Ca sources and two application schedules were compared for their effectiveness for increasing tissue Ca concentrations in 170 to 284 g field-grown tubers of `Atlantic' potato (Solanum tuberosum L.). Additional observations were made of internal physiological defects. Paired measures of tissue (periderm and nonperiderm) Ca concentration and internal quality (±hollow heart, ±internal brown spot) were made on individual tubers produced in plots fertilized with N at 224 kg·ha-1 and Ca at either 0 or 168 kg·ha-1, supplied from either gypsum, calcium nitrate or NHIB (9N-0P-0K-11Ca, a commercial formulation of urea and CaCl2). Application of N and Ca at emergence and hilling (nonsplit) was compared to application at emergence, hilling, and 4 and 8 weeks after hilling (split). Tuber yield and grade were unaffected by treatments. Split Ca application (from either calcium nitrate or NHIB) increased mean tuber nonperiderm tissue Ca concentrations and the percentage of tubers with an elevated Ca concentration in both years compared with non-Ca-supplemented controls. Split Ca application also resulted in greater increases in Ca in nonperiderm tissue than nonsplit Ca application in 1994. Although the correlation coefficient between Ca level in periderm and nonperiderm tissue of >400 individual tubers was highly significant in both study years, linear regression analyses suggested the Ca level in the two tissues were poorly related. Split application was associated with a 37% reduction in the incidence of internal tuber defects, relative to nonsplit application in 1994. Calcium application did not affect tuber internal quality based on means analysis, but chi-square analysis suggested that Ca concentration and internal quality of individual tubers may be related. The incidence of internal defects was 16.4% in tubers with nonperiderm tissue Ca >100 μg·g-1 dry weight compared to 10.6% in tubers with nonperiderm tissue Ca >100 μg·g-1 dry weight. These data suggest that 1) it is feasible to increase tuber Ca levels by field applications of moderate amounts of Ca, 2) tuber quality is impacted by N and Ca application schedule, and 3) Ca concentrations in tuber periderm and nonperiderm tissues may be controlled independently.

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21

Angker, L., and M. V. Swain. "Nanoindentation: Application to dental hard tissue investigations." Journal of Materials Research 21, no. 8 (August 1, 2006): 1893–905. http://dx.doi.org/10.1557/jmr.2006.0257.

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In the last decade, most publications on the mechanical properties of dental calcified tissues were based on nanoindentation investigation. This technique has allowed a better understanding of the mechanical behavior of enamel, dentin, and cementum at a nanoscale. The indentations are normally carried out using pointed or spherical indenters. Hardness and elastic modulus are measured as a function of indenter penetration depth and from the elastic recovery upon unloading. The unique microstructure of each calcified tissue significantly contributes to the variations in the mechanical properties measured. As complex hydrated biological composites, the relative proportions of the composite components, namely, inorganic material (hydroxyapatite), organic material, and water, determines the mechanical properties of the dental hard tissues. Many pathological conditions affecting dental hard tissues cause changes in mineral levels, crystalline structures, and mechanical properties that may be probed by nanoindentation. This review focuses on relevant nanoindentation techniques and their applications to enamel, dentin, and cementum investigations.

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22

Tanaka, Soichi, and Masashi Bando. "Autologous tissue breast reconstruction following the application of tissue expander." Breast Cancer 5, no. 1 (January 1998): 71–75. http://dx.doi.org/10.1007/bf02967418.

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23

Heinmöller, Ernst, Anke Bockholt, Meike Werther, Maria Ziemer, Annegret Müller, B. Michael Ghadimi, and Josef Rüschoff. "Laser Microdissection of Small Tissue Samples – Application to Chronic Pancreatitis Tissues." Pathology - Research and Practice 199, no. 6 (January 2003): 363–71. http://dx.doi.org/10.1078/0344-0338-00432.

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24

Kim, Se Hoon, Dong-Min Kim, Hyosup Shim, Junjeong Choi, Seong Hwan Park, Seung Min Song, Young Ho Shin, and Donghoon Choi. "Application of tissue microarray for atherectomized tissues from peripheral arterial disease." Pathology - Research and Practice 207, no. 9 (September 2011): 568–72. http://dx.doi.org/10.1016/j.prp.2011.06.007.

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25

Klontzas, Michail E., and Alexandros Protonotarios. "High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review." Bioengineering 8, no. 11 (November 10, 2021): 182. http://dx.doi.org/10.3390/bioengineering8110182.

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The rapid evolution of regenerative medicine and its associated scientific fields, such as tissue engineering, has provided great promise for multiple applications where replacement and regeneration of damaged or lost tissue is required. In order to evaluate and optimise the tissue engineering techniques, visualisation of the material of interest is crucial. This includes monitoring of the cellular behaviour, extracellular matrix composition, scaffold structure, and other crucial elements of biomaterials. Non-invasive visualisation of artificial tissues is important at all stages of development and clinical translation. A variety of preclinical and clinical imaging methods—including confocal multiphoton microscopy, optical coherence tomography, magnetic resonance imaging (MRI), and computed tomography (CT)—have been used for the evaluation of artificial tissues. This review attempts to present the imaging methods available to assess the composition and quality of 3D microenvironments, as well as their integration with human tissues once implanted in the human body. The review provides tissue-specific application examples to demonstrate the applicability of such methods on cardiovascular, musculoskeletal, and neural tissue engineering.

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ONODERA, Hiroshi. "Biomedical Application of Tissue Clearing Methods." Journal of the Japan Society for Precision Engineering 87, no. 12 (December 5, 2021): 922–25. http://dx.doi.org/10.2493/jjspe.87.922.

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27

Lakhera, Kanchan, Amit Kumar, Anju Rani, Rekha Dixit, and Sonali Rana. "Plant tissue culture and its application." Bulletin of Pure & Applied Sciences- Botany 37b, no. 1 (2018): 32. http://dx.doi.org/10.5958/2320-3196.2018.00004.6.

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Thorpe, Trevor A., and Indra S. Harry. "APPLICATION OF TISSUE CULTURE TO HORTICULTURE." Acta Horticulturae, no. 447 (October 1997): 39–50. http://dx.doi.org/10.17660/actahortic.1997.447.2.

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29

KERUT, EDMUND K. "Novel Application of Tissue Doppler Imaging." Echocardiography 15, no. 6 (August 1998): 553–61. http://dx.doi.org/10.1111/j.1540-8175.1998.tb00647.x.

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30

Mojtahed, Mohammad, Babak Saedi, Masoud Soleimani, Ali Reza Karimi Yazdi, and Ali Mojtahed. "Clinical Application of Tissue-Engineered Ossicle." Otolaryngology–Head and Neck Surgery 143, no. 2_suppl (August 2010): P225. http://dx.doi.org/10.1016/j.otohns.2010.06.480.

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31

Hahne, Günther. "Plant tissue culture: Application and limitations." Plant Science 77, no. 1 (January 1991): 137. http://dx.doi.org/10.1016/0168-9452(91)90190-j.

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32

Bu, Wenbo, Mengli Zhang, Fang Fang, and Qiang Wang. "An alternative application of tissue paper." Journal of the American Academy of Dermatology 84, no. 1 (January 2021): e1. http://dx.doi.org/10.1016/j.jaad.2020.03.111.

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33

Zhang, Yachen, Yong Tang, Ying Wang, and Liying Zhang. "Nanomaterials for Cardiac Tissue Engineering Application." Nano-Micro Letters 3, no. 4 (December 2011): 270–77. http://dx.doi.org/10.1007/bf03353683.

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34

Zhang, Jingyang, Haolin Chen, Meng Zhao, Guiting Liu, and Jun Wu. "2D nanomaterials for tissue engineering application." Nano Research 13, no. 8 (June 4, 2020): 2019–34. http://dx.doi.org/10.1007/s12274-020-2835-4.

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35

Markovic, Dejan, Ivana Karadzic, Vukoman Jokanovic, Ana Vukovic, and Vesna Vucic. "Biological aspects of application of nanomaterials in tissue engineering." Chemical Industry and Chemical Engineering Quarterly 22, no. 2 (2016): 145–53. http://dx.doi.org/10.2298/ciceq141231028m.

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Millions of patients worldwide need surgery to repair or replace tissue that has been damaged through trauma or disease. To solve the problem of lost tissue, a major emphasis of tissue engineering (TE) is on tissue regeneration. Stem cells and highly porous biomaterials used as cell carriers (scaffolds) have an essential role in the production of new tissue by TE. Cellular component is important for the generation and establishment of the extracellular matrix, while a scaffold is necessary to determine the shape of the newly formed tissue and facilitate migration of cells into the desired location, as well as their growth and differentiation. This review describes the types, characteristics and classification of stem cells. Furthermore, it includes functional features of cell carriers - biocompatibility, biodegradability and mechanical properties of biomaterials used in developing state-of-the-art scaffolds for TE applications, as well as suitability for different tissues. Moreover, it explains the importance of nanotechnology and defines the challenges and the purpose of future research in this rapidly advancing field.

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Bennett, Katherine, Mary Vargo, Guido Schnabel, and James E. Faust. "Calcium Application Method Impacts Botrytis Blight Severity on Petunia Flowers." HortScience 55, no. 2 (February 2020): 192–95. http://dx.doi.org/10.21273/hortsci14419-19.

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Two application methods of calcium (Ca), fertigation and spray, were investigated regarding their effects on Botrytis blight on petunia (Petunia ×hybrida) flowers. Plants were grown for 6 weeks with three nutrient solutions consisting of 0, 100, or 200 mg·L−1 Ca and weekly calcium chloride (CaCl2) sprays of 0, 750, or 1500 mg·L−1 Ca for a total of nine treatment combinations. Flowers were harvested, inoculated with Botrytis spores, placed in humidity chambers, and evaluated for Botrytis blight severity. Disease severity decreased by 57% and 70% when flowers were treated with Ca spray applications of 750 and 1500 mg·L−1 Ca, respectively; however, no change in disease severity occurred across the Ca fertigation applications. Ca concentration in the flower petal tissue increased with the Ca spray applications: the flower petal Ca concentration increased from 0.26% to 0.65% of tissue dry mass (DM) as the Ca spray application rate increased from 0 to 1500 mg·L−1. However, no change was observed across the Ca fertigation treatments. Leaf tissue Ca concentration increased from 2.1% to 3.2% DM as the fertigation solution increased from 0 to 200 mg·L−1 Ca, whereas spray application had no significant effects of leaf tissue Ca concentration. The results demonstrate that spray application is a more effective technique than fertigation application to provide higher Ca tissue concentrations in flowers, and that the Ca concentration in flower petal tissue is an important consideration when evaluating tissue susceptibility to Botrytis blight. Because of the high rate of fungicide resistance to Botrytis cinerea found in commercial greenhouses, spray applications of CaCl2 are an important disease management tool for commercial growers.

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Kumar, Pawan, Meenu Saini, Brijnandan S. Dehiya, Anil Sindhu, Vinod Kumar, Ravinder Kumar, Luciano Lamberti, Catalin I. Pruncu, and Rajesh Thakur. "Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications." Nanomaterials 10, no. 10 (October 13, 2020): 2019. http://dx.doi.org/10.3390/nano10102019.

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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38

Zhang, Shiqing, and Haibin Wang. "Current Progress in 3D Bioprinting of Tissue Analogs." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 1 (September 26, 2018): 70–78. http://dx.doi.org/10.1177/2472630318799971.

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Tissue engineering has progressed tremendously over recent decades through the generation of functional tissue analogs. Traditional approaches based on seeding cells into scaffold are limited in their capacity to produce tissues with precise biomimetic properties. Three-dimensional (3D) bioprinting is one kind of fabrication technology used to precisely dispense cell-laden biomaterials for the construction of functional tissues or organs. In recent years, much research progress has been made in 3D bioprinting technology and its application in generating tissue analogs, including skin, heart valves, blood vessels, bone, and cardiac tissue. However, it still faces many technical challenges. In this review, we introduce the current progress in 3D bioprinting technology and focus on biomaterials and their potential applications in regenerative medicine and drug discovery. Current challenges are also discussed.

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Kucinska-Lipka, Justyna, Helena Janik, and Iga Gubanska. "Ascorbic Acid in Polyurethane Systems for Tissue Engineering." Chemistry & Chemical Technology 10, no. 4s (December 25, 2016): 607–12. http://dx.doi.org/10.23939/chcht10.04si.607.

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The introduction of the paper was devoted to the main items of tissue engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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Li, Haojiang, Shi Shen, Haitao Fu, Zhenyong Wang, Xu Li, Xiang Sui, Mei Yuan, Shuyun Liu, Guiqin Wang, and Quanyi Guo. "Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering." Stem Cells International 2019 (January 13, 2019): 1–18. http://dx.doi.org/10.1155/2019/9671206.

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The inflammatory response to chronic injury affects tissue regeneration and has become an important factor influencing the prognosis of patients. In previous stem cell treatments, it was revealed that stem cells not only have the ability for direct differentiation or regeneration in chronic tissue damage but also have a regulatory effect on the immune microenvironment. Stem cells can regulate the immune microenvironment during tissue repair and provide a good “soil” for tissue regeneration. In the current study, the regulation of immune cells by mesenchymal stem cells (MSCs) in the local tissue microenvironment and the tissue damage repair mechanisms are revealed. The application of the concepts of “seed” and “soil” has opened up new research avenues for regenerative medicine. Tissue engineering (TE) technology has been used in multiple tissues and organs using its biomimetic and cellular cell abilities, and scaffolds are now seen as an important part of building seed cell microenvironments. The effect of tissue engineering techniques on stem cell immune regulation is related to the shape and structure of the scaffold, the preinflammatory microenvironment constructed by the implanted scaffold, and the material selection of the scaffold. In the application of scaffold, stem cell technology has important applications in cartilage, bone, heart, and liver and other research fields. In this review, we separately explore the mechanism of MSCs in different tissue and organs through immunoregulation for tissue regeneration and MSC combined with 3D scaffolds to promote MSC immunoregulation to repair damaged tissues.

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Jing, Xirui, Zekang Xiong, Zian Lin, and Tingfang Sun. "The Application of Black Phosphorus Nanomaterials in Bone Tissue Engineering." Pharmaceutics 14, no. 12 (November 28, 2022): 2634. http://dx.doi.org/10.3390/pharmaceutics14122634.

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Recently, research on and the application of nanomaterials such as graphene, carbon nanotubes, and metal–organic frameworks has become increasingly popular in tissue engineering. In 2014, a two-dimensional sheet of black phosphorus (BP) was isolated from massive BP crystals. Since then, BP has attracted significant attention as an emerging nanomaterial. BP possesses many advantages such as light responsiveness, electrical conductivity, degradability, and good biocompatibility. Thus, it has broad prospects in biomedical applications. Moreover, BP is composed of phosphorus, which is a key bone tissue component with good biocompatibility and osteogenic repair ability. Thereby, BP exhibits excellent advantages for application in bone tissue engineering. In this review, the structure and the physical and chemical properties of BP are described. In addition, the current applications of BP in bone tissue engineering are reviewed to aid the future research and application of BP.

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Lee, Eunjee A., Hyungu Yim, Jiseung Heo, Hwan Kim, Giyoung Jung, and Nathaniel S. Hwang. "Application of magnetic nanoparticle for controlled tissue assembly and tissue engineering." Archives of Pharmacal Research 37, no. 1 (December 6, 2013): 120–28. http://dx.doi.org/10.1007/s12272-013-0303-3.

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Abedi, Niloufar, Zahra Sadat Sajadi-Javan, Monireh Kouhi, Legha Ansari, Abbasali Khademi, and Seeram Ramakrishna. "Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature." Antioxidants 12, no. 3 (February 27, 2023): 594. http://dx.doi.org/10.3390/antiox12030594.

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Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts.

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Pongratz, T., K. Siegrist, C. Burgmeier, H. D. Barth, C. G. Schmedt, and R. Sroka. "Endovenous Laser Application." Phlebologie 42, no. 03 (March 2013): 121–29. http://dx.doi.org/10.12687/phleb2134-3-2013.

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SummaryIntroduction: Endoluminal vein treatment is a promising minimal invasive treatment option for peoples suffering from varicose veins. The basic mechanism underlying this procedure is to selectively induce heat in the vessel wall with the result of denaturation of proteins and shrinkage of collagen fibers due to energy application. So far energy could be applied either as RF-current, laser light or water steam. The different approaches to deliver such forms of energies are described.Methods: Investigations on heat dependent vein tissue effects were performed. The degree of shrinkage and wall thickening due to heat induction was calculated. Tensile test on vein tissue were performed. Investigation using the radial emitting laser fibre in the ox-foot-model under reproducible condition were done and wavelengths dependent tissue reaction were explored.Results: The experiments clearly demonstrate the degree of the shrinkage of length and diameter, the thickening of the vein wall, as well as the decrease of the elasticity of the tissue. The optical irradiation pattern of the radial emitting laser fiber serves for safe and reproducible energy application directly to the vein wall. Using a laser wavelength with high absorption by the tissue water needs reduced irradiation and irradiance compared to wavelengths with less water absorption. Conclusion: An experimental approach to improve laser application for endovenous varicose treatment is described. Laser parameters and treatment parameters were found which are now under clinical testing. The demonstrated tissue effects may help to find further arguments for clinical findings and sensations described by the patients during follow-up.

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MILTHORPE, BRUCE K. "APPLICATION OF BIOMECHANICS TO TISSUE ENGINEERING: A PERSONAL VIEW." Journal of Mechanics in Medicine and Biology 08, no. 02 (June 2008): 153–60. http://dx.doi.org/10.1142/s0219519408002590.

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Cellular biomechanics is an area of study that is receiving more attention as time progresses. The response of cells to their mechanical environment, including biomechanical stimuli, has far-reaching ramifications for the area of tissue engineering, especially for tissues designed to withstand mechanical loading (e.g. bone, cartilage, tendons and ligaments, and arteries). The effects of mechanical stimuli on cells are only recently being examined, and the potential role of mechanical stimuli in tissue engineering is still one that is largely ignored in the design of tissue engineering scaffolds. The relationship of mechanical properties of scaffolds or of mechanical stimuli to cell behavior is complex, but vital to the development of the field. Also, understanding the complex interplay of form and environment on cells involves an increase in our knowledge of how cells react to their total environment including mechanical stimuli and material properties. In order to improve tissue engineering outcomes, a nexus must be developed between the mechanical, biochemical, and biological studies of cellular behavior, in the context of extremely complex systems.

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Brodetskyi, I. S., V. O. Malanchuk, and V. E. Dosenko. "Application of microRNA-34a for diagnosis of pleomorphic adenomas of salivary glands." Klinicheskaia khirurgiia 86, no. 10 (October 21, 2019): 67–70. http://dx.doi.org/10.26779/2522-1396.2019.10.67.

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Objective. Determination of expression of microRNA-34a in tissues of pleomorphic adenomas of large salivary glands, adjacent to tumor salivary gland tissue, intact tissue of a salivary gland, which was not connected with the tumor, and in a venous blood as well. Materials and methods. The investigation was conducted in 20 patients, suffering benign tumors of large salivary glands (pleomorphic adenomas). Expression was estimated, using adverse transcription and quantitative polymerase chain reaction in regime of a real time. Results. Analysis of the expression level for microRNA-34a was conducted in the tumoral tissue, adjacent to the tumor salivary gland tissue, and in intact tissue of salivary gland, which lacked a link with the tumor, the venous blood in patients, suffering pleomorphic adenomas of large salivary glands, and there was revealed, that it have appeared the highest in the salivary gland adjacent to the tumor - (1052.02 ± 367.20, comparing with the same index in the intact gland - 47.72 ± 28.93). Conclusion. Level of expression of microRNA-34a in the tissues of pleomorphic adenomas of salivary glands, which is in 11 times higher, than in norm (in intact tissue of salivary gland), may be applied as a genetic marker for verification of these tumors.

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47

Hasan, Anwarul, Md Nurunnabi, Mahboob Morshed, Arghya Paul, Alessandro Polini, Tapas Kuila, Moustafa Al Hariri, Yong-kyu Lee, and Ayad A. Jaffa. "Recent Advances in Application of Biosensors in Tissue Engineering." BioMed Research International 2014 (2014): 1–18. http://dx.doi.org/10.1155/2014/307519.

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Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.

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Grant, C. A., and L. D. Bailey. "Interactions of zinc with banded and broadcast phosphorus fertilizer on the concentration and uptake of P, Zn, Ca and Mg in plant tissue of oilseed flax." Canadian Journal of Plant Science 73, no. 1 (January 1, 1993): 17–29. http://dx.doi.org/10.4141/cjps93-004.

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Field experiments on four sites over 3 yr evaluated the effect of banded and broadcast applications of fertilizer P, with and without application of Zn on the tissue concentration and uptake by the plant of Zn, P, Ca, and Mg in oilseed flax (Linum usitatissimum L.). Residual effects of the P applications were also evaluated over five site-years. Banded applications of P tended to be more effective than either broadcast applications or residual P in increasing tissue concentration and uptake of P. Zinc application tended to decrease P concentration in the tissue where P levels were relatively high. When Zn was applied with banded P applications, it tended to reduce P uptake by the plant; when it was applied with broadcast P, it tended to increase P uptake by the plant. Changes in P uptake in response to Zn application generally reflected changes in dry matter production. When an increase in Zn concentration in the tissue or uptake by the plant occurred due to Zn applications, it was primarily when the Zn was applied with broadcast P fertilizer or where P had been broadcast the previous season. The increase in uptake of Zn generally reflected increased dry matter yield. Banded applications of P tended to produce lower tissue concentrations of Zn than did broadcast applications. Zinc concentration in the tissue also tended to be reduced by residual P from applications the previous season. Changes in Ca concentration in the tissue and uptake by the plant generally reflected changes in dry matter production. However, Mg concentration in the tissue and uptake by the plant were increased by P applications, particularly where P was banded. The increase in concentration in the tissue and uptake of Mg by the plant with application of P indicates that applications of P increase the ability of the plant to absorb Mg, presumably due to an effect on the absorption-translocation system within the plant. Key words: Flax, P placement, P, Zn, Ca, Mg

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Tan, Hui-Li, Sin-Yeang Teow, and Janarthanan Pushpamalar. "Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration." Bioengineering 6, no. 1 (February 11, 2019): 17. http://dx.doi.org/10.3390/bioengineering6010017.

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Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP–hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP–hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed.

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Kook, Yun-Min, Yoon Jeong, Kangwon Lee, and Won-Gun Koh. "Design of biomimetic cellular scaffolds for co-culture system and their application." Journal of Tissue Engineering 8 (January 1, 2017): 204173141772464. http://dx.doi.org/10.1177/2041731417724640.

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The extracellular matrix of most natural tissues comprises various types of cells, including fibroblasts, stem cells, and endothelial cells, which communicate with each other directly or indirectly to regulate matrix production and cell functionality. To engineer multicellular interactions in vitro, co-culture systems have achieved tremendous success achieving a more realistic microenvironment of in vivo metabolism than monoculture system in the past several decades. Recently, the fields of tissue engineering and regenerative medicine have primarily focused on three-dimensional co-culture systems using cellular scaffolds, because of their physical and biological relevance to the extracellular matrix of actual tissues. This review discusses several materials and methods to create co-culture systems, including hydrogels, electrospun fibers, microfluidic devices, and patterning for biomimetic co-culture system and their applications for specific tissue regeneration. Consequently, we believe that culture systems with appropriate physical and biochemical properties should be developed, and direct or indirect cell–cell interactions in the remodeled tissue must be considered to obtain an optimal tissue-specific microenvironment.

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