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Дисертації з теми "Thyroid hormones Therapeutic use"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 31 липня 2025

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1

Veltri, Flora. "Variables influencing thyroid function during pregnancy and their potential use in clinical practice." Doctoral thesis, Universite Libre de Bruxelles, 2020. https://dipot.ulb.ac.be/dspace/bitstream/2013/313347/4/TDM.pdf.

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Pregnancy is a condition leading to an important strain on thyroid morphology and function.A normal functioning of the thyroid gland in the mother is essential for the early fetal development, since the fetal thyroid does not produce thyroid hormones until the end of the first trimester (approximately 12 to 14 weeks).The impact of thyroid dysfunction (and especially hypothyroidism) during pregnancy is well documented and has been associated with a number of obstetrical complications, such as premature delivery, low birth weight and even fetal death. In view of all changes in thyroid physiology

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2

伍伯堯 and Pak-yiu Ng. "Investigation on the differential expression and hormonal regulation of olfactomedin in uterus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557765.

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3

Roberts, April M. "Steroid hormone treatments alter growth characteristics in transformed human ovarian cell lines." Virtual Press, 2003. http://liblink.bsu.edu/uhtbin/catkey/1265095.

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4

Babicheva, Rosalie. "Radiation doses to family members of patients treated with Iodine-131 therapy." Master's thesis, School of Medical Radiation Sciences, Faculty of Health Sciences, 2001. http://hdl.handle.net/2123/5318.

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Thesis (M. App. Sc.)--University of Sydney, 2001.<br>Title from title screen (viewed Aug. 11, 2009) Includes tables. Submitted in fulfilment of the requirements for the degree of Master of Applied Science to the Faculty of Health Sciences. Includes bibliographical references. Also available in print form.

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5

Mugari, Mufaro Buhlebenkosi. "The inhibitory effect of rooibos on cytochromes P450 and downstream in vitro modulation of steroid hormones." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96680.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: This study describes: 1. Substrate binding assays investigating the effects of methanolic extracts of unfermented and fermented Rooibos on the binding of natural substrates to ovine adrenal microsomal and mitochondrial P450 enzymes, demonstrating the interference of substrate binding in the presence of the Rooibos extracts. 2. The effects of selected flavonoids (quercetin, rutin and aspalathin) on the binding of natural substrates to ovine adrenal microsomal and mitochondrial P450 enzymes, demonstrating interference of su

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6

Meyer, Eric. "Comparative bioavailability and ranking of topical corticosteroid formulations." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1001471.

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Numerous experiments in recent years have indicated differences in the bioavailability of corticosteroids from seemingly identical topical dosage forms. The human blanching assay was utilized in this study to assess the comparative blanching activities of various locally manufactured proprietary corticosteroid preparations. The first experiment was performed to assess the relative blanching activities of six semi - solid preparations containing the same concentration of betamethasone 17-valerate. The preparations used were Betnovate cream and ointment, Persivate cream and ointment and Celestod

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7

林穎華 and Wing-wah Phoebe Lam. "A systematic review of postoperative treatments for laser eye surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970643.

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8

Magnus, Ashley Denis. "Aspects of the bioavailability of topical corticosteroid formulations." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1009516.

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Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17-valer ate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found tha

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9

Milliken, Erin L. "USE OF A TRANSGENIC MOUSE MODEL OF OVARIAN HYPERSTIUMLUATION TO IDENTIFY THERAPEUTIC TARGETS AND MECHANISMS IN HORMONE-INDUCED MAMMARY CANCER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1121273034.

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10

Salb, Nicole [Verfasser], та Peter [Akademischer Betreuer] Nelson. "Application of engineered mesenchymal stem cells as therapeutic vehicles for the treatment of solid tumors : HIF1α-based targeting and the influence of thyroid hormones / Nicole Salb ; Betreuer: Peter Nelson". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1171131372/34.

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11

Horn, Je'nine. "The analysis of 6- and 24-hour iodine-131 thyroid uptake in patients with Graves' disease at Universitas Hospital." Thesis, [Bloemfontein?] : Central University of Technology, Free State, 2007. http://hdl.handle.net/11462/102.

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Thesis (M.Tech.)(Nuclear Medicine) -- Central University of Technology, free State, 2007<br>In the South African Health Services (SAHS) it is each health worker’s responsibility to find ways to reduce health care cost and improve health service to the public. The measurement of radioactive iodine uptake (RAIU) by the thyroid gland for diagnostic purposes has been used as early as the 1940s. The 24-hour (hr) iodine-131 (131I) uptake measurement is traditionally used for the calculation of the 131I administered activity for therapy dosage. This entails that the patient’s hospitalisation is prol

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12

Schloms, Lindie. "The inhibition of adrenal steroidogenic enzymes and modulation of glucocorticoid levels in vitro and in vivo by aspalathus linearis (rooibos)." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97000.

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Thesis (PhD)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: This study describes: • the influence of a methanolic extract of unfermented Rooibos and five major Rooibos flavonoids, aspalathin, nothofagin, rutin, orientin and vitexin, on the activities of key adrenal steroidogenic enzymes - cytochrome P450 17β- hydroxylase/17,20-lyase (CYP17A1), 3β-hydroxysteroid dehydrogenase • the development of a novel UPLC-MS/MS method for the separation and quantification of 21 adrenal steroid metabolites; • the influence of Rooibos and aforementioned flavonoids on adrenal steroid hormone prod

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13

Parreira, Samara Lamounier Santana. ""Quantificação da força muscular e habilidades motoras de pacientes com distrofia muscular de Duchenne, em tratamento com corticoterapia"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-04042006-153416/.

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Em 32 pacientes com Distrofia Muscular de Duchenne, em corticoterapia, avaliou-se a evolução da força muscular, ao longo de 14 meses, mensalmente no primeiro semestre e a cada dois meses no segundo e terceiro semestre. Testes empregados: escala "Medical Research Council", Hammersmith "motor ability score", levantamento de peso cronometragem do tempo para manobra de Gowers e para percorrer 9 metros. O estudo revelou tendência de estabilidade da força muscular durante o acompanhamento e que para avaliar objetivamente a força muscular são suficientes intervalos de três meses no primeiro semestre

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14

Palvie, Stefanie Michelle. "An investigation into the neuroprotective effects of dehydroepiandrosterone." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003260.

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Dehydroepiandrosterone, a C-19 steroid, is found endogenously with the highest circulating serum levels. It is converted to important steroids such as the sex hormones oestrogen and testosterone. DHEA has come under the spotlight as a purported “fountain of youth” due to its well-characterised age-related decline. The supplementation of DHEA in both the elderly and those with a pathophysiological deficiency has been shown to be of benefit, particularly with regard to wellbeing and depression. The role of DHEA in the periphery has not been elucidated beyond its role as a precursor hormone in se

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15

Fernandes, Roberta Possato. "Quantificação do RNAm de tireoglobulina em sangue periférico de pacientes com câncer diferenciado de tireóide: acompanhamento a longo prazo." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15042009-154717/.

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O carcinoma diferenciado de tireóide (CDT) abrange 95% de todas as doenças malignas da tireóide. Nos EUA, aumentou em 2,4 vezes nos últimos anos (1973-2002). O seu tratamento inclui tireoidectomia total, seguido por terapia com radioiodo e supressão do TSH com L-tiroxina. A doença pode recidivar em ~20% dos casos, sendo necessária avaliação periódica através de exames de imagens e dosagem de tireoglobulina sérica (TGs). Os Anticorpos (Acs) anti-TG podem ser detectados em 15 a 25% dos pacientes, comprometendo, parcialmente, o uso da TGs como marcador de recidiva do câncer. Um método alternativo

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16

Cotrim, Denise Moreira de Andrade. "Estudo das interleucinas no processo inflamatório na doença pulmonar obstrutiva crônica, Prednisona/uso terapêutico." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09102014-091632/.

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Embora a utilização do corticóide oral não seja indicada no tratamento de manutenção na doença pulmonar obstrutiva crônica, identificamos em nosso ambulatório, um grupo de pacientes que fazem uso desta medicação de forma continuada e, nos quais, todas as tentativas anteriores de retirada da medicação, havia resultado em exacerbação dos sintomas. O objetivo deste estudo foi o de analisar os fenômenos inflamatórios associados à tentativa de redução progressiva do corticóide oral nesses doentes. Avaliamos o escarro induzido de 14 pacientes usuários crônicos de corticóide. Após a avaliação basal,

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17

"Apoptotic effects of iodine in thyroid cancer cells." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074822.

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This reseach firstly investigated iodine-induced apoptotic effects and the underlying mechanism in thyroid cancer cells. Results indicated that apoptosis induced by iodine, especially at high dose of iodine (100 muM), was mitochondrial-mediated, with the loss of mitochondrial membrane potential, Bak up-regulation, caspase 3 activation and cytochrome C release from mitochondria. Iodine treatment decreased the level of mutant p53 including the R273H mutant that possesses anti-apoptotic features while increased the p21 level. The block of p21 significantly prevented iodine-induced apoptosis. High

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18

Vale, Catarina Afonso Couto e. "The role of thyroid hormones in heart failure: triiodothyronine as a therapeutic target in HFpEF." Master's thesis, 2019. https://hdl.handle.net/10216/119942.

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19

Vale, Catarina Afonso Couto e. "The role of thyroid hormones in heart failure: triiodothyronine as a therapeutic target in HFpEF." Dissertação, 2019. https://hdl.handle.net/10216/119942.

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20

"The effect of corticosteroid therapy on growth in Black South African children with nephrotic syndrome." Thesis, 1986. http://hdl.handle.net/10413/2433.

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The most useful drugs in the management of nephrotic syndrome are the corticosteroids. These drugs are as well known for their adverse effects as they are for their therapeutic advantages. The two most common paediatric side effects are suppression of linear growth and posterior subcapsular cataracts. Both of these untoward effects are insiduous and therefore less easily perceived. Although many workers have studied the growth inhibiting effects of the corticosteroids in the various diseases e.g. asthma, very little work was done to investigate these effects in patients with nephrotic syndrome

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21

"Investigation into the mechanism of action of corticosteroids to antagonise cisplatin- and motion-induced emesis." 2000. http://library.cuhk.edu.hk/record=b5890434.

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Sam Sze Wing.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 156-184).<br>Abstracts in English and Chinese.<br>Publications based on work in this thesis --- p.ii<br>Abstract --- p.iii<br>Acknowledgements --- p.vii<br>Chapter 1 --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Corticosteroids --- p.2<br>Chapter 1.1.1 --- Chemical Structure of Steroids --- p.3<br>Chapter 1.1.2 --- Biosynthesis of Endogenous Corticosteroids --- p.3<br>Chapter 1.1.2.1 --- Regulation of Cortisol synthesis and negative feedback system --- p.4<br>Chapter 1

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22

"Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and mitochondrial dysfunction." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075047.

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Additionally, cyclosporin A, an inhibitor of the mitochondrial permeability transition (MPT) pore, failed to prevent hIAPP-induced DeltaPsim collapse, cytochrome c and AIF release and caspase-3 activation, indicating that the MPT pore was not involved in hIAPP-induced apoptosis. On the other hand, potential crosstalk between the extrinsic and intrinsic apoptotic pathways was demonstrated by cleavage of Bid by caspase-8 in the apoptotic process triggered by hIAPP.<br>It is widely accepted that human islet amyloid polypeptide (hIAPP) aggregation plays an important role in the loss of insulin-pro

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