Добірка наукової літератури з теми "Thymidine monophosphate"
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Статті в журналах з теми "Thymidine monophosphate"
Miyasaki, Taiko, and Katsuhiko Harada. "Effects of specific purine and pyrimidine compounds on the ingestion of test diets by the abalone Haliotis discus and the oriental weatherfish Misgurnus anguillicaudatus." Marine and Freshwater Research 54, no. 3 (2003): 235. http://dx.doi.org/10.1071/mf02066.
Повний текст джерелаGogolin, Lars, Ralf Seidel, Martin Engelhard, Roger S. Goody, and Christian F. W. Becker. "Semisynthesis of human thymidine monophosphate kinase." Biopolymers 94, no. 4 (June 3, 2010): 433–40. http://dx.doi.org/10.1002/bip.21398.
Повний текст джерелаWu, R. R., L. A. Hamlow, C. C. He, Y. w. Nei, G. Berden, J. Oomens, and M. T. Rodgers. "The intrinsic basicity of the phosphate backbone exceeds that of uracil and thymine residues: protonation of the phosphate moiety is preferred over the nucleobase for pdThd and pUrd." Physical Chemistry Chemical Physics 19, no. 45 (2017): 30351–61. http://dx.doi.org/10.1039/c7cp05521h.
Повний текст джерелаThompson, L. F. "Ecto-5'-nucleotidase can provide the total purine requirements of mitogen-stimulated human T cells and rapidly dividing human B lymphoblastoid cells." Journal of Immunology 134, no. 6 (June 1, 1985): 3794–97. http://dx.doi.org/10.4049/jimmunol.134.6.3794.
Повний текст джерелаGul, Sana, Ruqaiya Khalil, Zaheer Ul-Haq, and Mohammad S. Mubarak. "Computational Overview of Mycobacterial Thymidine Monophosphate Kinase." Current Pharmaceutical Design 26, no. 15 (May 18, 2020): 1676–81. http://dx.doi.org/10.2174/1381612826666200403114152.
Повний текст джерелаGustavsson, Thomas, Alexei Sharonov, and Dimitra Markovitsi. "Thymine, thymidine and thymidine 5′-monophosphate studied by femtosecond fluorescence upconversion spectroscopy." Chemical Physics Letters 351, no. 3-4 (January 2002): 195–200. http://dx.doi.org/10.1016/s0009-2614(01)01375-6.
Повний текст джерелаSchlosser, Julika, Julian F. M. Hebborn, Daria V. Berdnikova, and Heiko Ihmels. "Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane." Chemistry 5, no. 2 (May 11, 2023): 1220–32. http://dx.doi.org/10.3390/chemistry5020082.
Повний текст джерелаTomasz, Jeno, Barbara Ramsay Shaw, Ken Porter, Bernard F. Spielvogel, and Anup Sood. "5′-P-Borane-Substituted Thymidine Monophosphate and Triphosphate." Angewandte Chemie International Edition in English 31, no. 10 (October 1992): 1373–75. http://dx.doi.org/10.1002/anie.199213731.
Повний текст джерелаVan Poecke, Sara, Hélène Munier-Lehmann, Olivier Helynck, Matheus Froeyen, and Serge Van Calenbergh. "Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase." Bioorganic & Medicinal Chemistry 19, no. 24 (December 2011): 7603–11. http://dx.doi.org/10.1016/j.bmc.2011.10.021.
Повний текст джерелаKeita, M., A. Kumar, B. Dali, E. Megnassan, M. I. Siddiqi, V. Frecer, and S. Miertus. "Quantitative structure–activity relationships and design of thymine-like inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis with favourable pharmacokinetic profiles." RSC Adv. 4, no. 99 (2014): 55853–66. http://dx.doi.org/10.1039/c4ra06917j.
Повний текст джерелаДисертації з теми "Thymidine monophosphate"
Tourneux, Lise. "Propriétés structurales et catalytiques des thymidine monophosphate kinases bactériennes." Paris 6, 1999. http://www.theses.fr/1999PA066499.
Повний текст джерелаGasse, Cécile. "Synthèse et évaluation d'inhibiteurs de la thymidine monophosphate kinase de "mycobacterium tuberculosis"." Paris 5, 2006. http://www.theses.fr/2006PA05P628.
Повний текст джерелаM. Tuberculosis thymidine monophosphate kinase (TMPKmt) is a potential target for the development of new antituberculous agents. This enzyme is directly implied in M. Tuberculosis growth and catalyses the last specific step of the dTTP synthesis i. E. The phosphorylation of the dTMP in dTDP by using ATP as preferred phosphate donor. This manuscript describes the synthesis and evaluation of TMPKmt specific inhibitors. Thus, nucleosidic analogues were synthesized using Ap5T as a well known inhibitor of the nucleoside monophosphate kinases model. Hence, analogues of the two substrates were linked by a spacer. In a second approach, a new family of non-nucleosidic molecules were designed using a modelling program (LEA3D) and were synthesized. The affinities of both families of molecules were determined in vitro on TMPKmt and the human TMPK. Moreover, some of the non-nucleosidic analogues also turned out to be active on M. Bovis BCG growth
El, Omari Kamel. "Etudes structurales et biochimiques de protéines cibles pour le développement de molécules antivirales et antitumorales." Paris 6, 2007. http://www.theses.fr/2007PA066024.
Повний текст джерелаChen, Jun-Xian, and 陳俊賢. "Monitoring thymidine monophosphate and thymidne diphosphate by capillary electrophoresis with pH junction and formation of ion complex for online preconcentration." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/74049617344436707965.
Повний текст джерела國立暨南國際大學
應用化學系
100
The formation of thymidine monophosphate (TMP) and thymidine diphosphate (TDP), which are precursors for DNA synthesis, are catalyzed by thymidine kinase (TK) and thymidylate kinase (TMPK), respectively. Therefore, TK and TMPK activity can be used as markers of DNA synthesis and cell proliferation. In this study, capillary electrophoresis coupled with online preconcentration techniques was used to quantify TMP and TDP in order to estimate the activity of TK and TMPK. Prior to sample injection, a small plug of HCl was pushed into the capillary. The cationic polymer Polyethylenimine (PEI) 2000 in the sample buffer (pH 8.0) formed a complex with ATP primarily. Therefore TMP and TDP were injected selectively into a PEI 2000 modified capillary with a reversed electroosmotic flow by the electrokinetic injection. Then the pH junction of the alkaline sample buffer and the HCl plug made TMP and TDP accumulated. The analyte and PEI 2000 in the background electrolyte (BGE) formed ion-paired complex, thereby decreasing its mobility and resulting in sample stacking. Several parameters affecting the online preconcentration and separation were investigated, including the pH and concentration of the BGE, the concentrations of cationic modifier PEI 2000 in the sample buffer and the BGE, the concentration and the injection volume of the HCl plug, the voltage and time period of the electrokinetic injection, and the separation voltage. The results showed that the PEI 2000 in the BGE resolved the analytes from ATP effectively. Good separation with high separation efficiency and reproducibility was achieved within 7 min under optimal conditions. In comparison with the previous method, the sensitivity was enhanced up to two orders of magnitude with the present method. The linear range of the method was 50-5000 nM for TDP and TMP. The limits of detection of TDP and TMP were 34.9 nM and14.8 nM, respectively. The proposed method may be applied to TK and TMPK activity assays in cells.
Luo, Yaling, and 羅雅玲. "Monitoring thymidine monophosphate by capillary electrophoresis with pH junction and formation of ion complex for online preconcentration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/01897101812372573201.
Повний текст джерела國立暨南國際大學
應用化學系
99
The code of life – DNA is composed by deoxyadenosine triphosphate (dATP), deoxycytidine triphosphate (dCTP), thymidine triphosphate (TTP), and deoxyguanosine triphosphate (dGTP). There are two ways to form thymidine monophosphate (TMP) which is further phosphorylated to TTP. One is de novo pathway, and the other is salvage pathway. In the salvage pathway, thymidine is phosphorylated to TMP catalyzed by thymidine kinase (TK). Therefore, the activity of TK is a marker of DNA synthesis and cell proliferation. This study combined capillary electrophoresis (CE) with online preconcentration techniques to monitor TMP. TMP and adenosine triphosphate (ATP) are negatively charged in the sample buffer at pH 8.0. The dynamic pH junction between the background electrolyte and the sample buffer results in the decrease of the charges of analytes. Addition of hexadimethrine bromide (HDB) into the background electrolyte reverses the electroosmotic flow and speeds up the migration of negatively charged analytes. Furthermore, HDB could form ion complex with negatively charged analytes, which increases mass/charge ratios of the analytes. Besides, -cyclodextrin (-CD) was added to resolve TMP from adenosine monophosphate (AMP). Several parameters affecting the separation were optimized including the concentration of HDB, the concentration and the pH value of the background electrolytes and the concentration of -CD. This method is linear in the range of 0.5 M to 50 M and the limit of detection is 0.85 M for TMP. This method can be applied to determine the cellular TK activity in future.
Chaudhary, Santosh Kumar. "Structural and functional studies on DNA synthesis and repair proteins." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5320.
Повний текст джерелаЧастини книг з теми "Thymidine monophosphate"
YOSHIDA, H., R. L. HETTICH, J. A. LAVERNE, K. B. JACOBSON, and J. E. TURNER. "CHARACTERIZATION OF RADIATION-INDUCED PRODUCTS IN THYMIDINE 3'- MONOPHOSPHATE BY LASER DESORPTION FTMS." In Radiation Research: A Twentieth-century Perspective, 400. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-12-168561-4.50125-6.
Повний текст джерелаWilliam Tong, C. Y. "Antivirals." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0059.
Повний текст джерелаТези доповідей конференцій з теми "Thymidine monophosphate"
Van Rompaey, Philippe, Vanheusden Veerle, Sylvie Pochet, Hélene Munier-Lehmann, Matheus Froeyen, Piet Herdewijn, and Serge Van Calenbergh. "Thymidine (monophosphate) analogues as Mycobacterium tuberculosis thymidylate kinase inhibitors." In XIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205393.
Повний текст джерелаVan Calenbergh, Serge, Ineke Van Daele, Sara Van Poecke, Matheus Froeyen, Hélene Munier Lehmann, and Jan Balzarini. "From M. tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitors towards mitochondrial thymidine kinase (TK-2) inhibitors." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810087.
Повний текст джерела