Дисертації з теми "THERAPEUTICS ACTION"
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Crowley, John J. "Enabling carers to administer depot injections : an action research study." Thesis, University of Greenwich, 2014. http://gala.gre.ac.uk/11617/.
Повний текст джерелаRomero-Canelón, Isolda. "Design and mechanism of action of organometallic anticancer complexes." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55211/.
Повний текст джерелаVieira, Goncalves Leonam. "Mechanisms of virucidal action of alcohol and metallic ions against nonenveloped viruses." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/111705/.
Повний текст джерелаCrisford, Anna. "An investigaton into mode of action and selective toxicity of the novel antiparasitic emodepside." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/338971/.
Повний текст джерелаCooper, David L., Derek E. Murrell, David Roane, and Sam Harirforoosh. "Effects of Formulation Design on Niacin Therapeutics: Mechanism of Action, Metabolism, and Drug Delivery." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/7166.
Повний текст джерелаUllah, Imran. "A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum." Thesis, Keele University, 2016. http://eprints.keele.ac.uk/2411/.
Повний текст джерелаWortley, Michael. "An investigation into the efficacy and mechanisms of action of novel therapeutics for chronic cough." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29125.
Повний текст джерелаSayce, Andrew Cameron. "Iminosugars as dengue virus therapeutics : molecular mechanisms of action of a drug entering clinical trials." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8d4da0ce-bfa6-447d-a280-630479f898af.
Повний текст джерелаAl, Matrood W. A. A. "Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics." Thesis, Liverpool John Moores University, 2016. http://researchonline.ljmu.ac.uk/4727/.
Повний текст джерелаMubaraki, Murad. "Pharmacometabolomic study of the human malaria parasite, Plasmodium falciparum : new insights into parasite biology and mode of drug action." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/12337/.
Повний текст джерелаWong, Michael. "Rational design of small molecule probes for investigating the mechanism of action of the chemotherapeutic agents CDDO and artemisinin." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2006368/.
Повний текст джерелаHughes, George Marc. "Design and mechanism of action of novel organoiridium(iii) azopyridine anticancer complexes." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/103913/.
Повний текст джерелаSchroeder, Frederick Albert. "A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/370.
Повний текст джерелаCourtney, Hamish. "Determinants of insulin action : physiological and therapeutic implications." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343100.
Повний текст джерелаBuckshey, Sakshi. "Remineralizing action of CPP-ACP reagents on artificial carious lesions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46848915.
Повний текст джерелаMakhani, Kiran, and Kiran Makhani. "Mechanism of Action of ERBB Decoy Cancer Therapeutic Peptide SAH5." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626139.
Повний текст джерелаWaters, Cerith. "Acceptance and commitment therapy : efficacy and mechanisms of therapeutic action." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/37760/.
Повний текст джерелаSpandler, Helen. "Asylum to action : Paddington Day Hospital, therapeutic communities and beyond." Thesis, Manchester Metropolitan University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247203.
Повний текст джерелаAl-Zobaidy, Mohammed. "Differential actions of methlyarginines in the rat aorta." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3838/.
Повний текст джерелаLilliengren, Peter. "Exploring therapeutic action in psychoanalytic psychotherapy : Attachment to therapist and change." Doctoral thesis, Stockholms universitet, Psykologiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-106501.
Повний текст джерелаAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Epub ahead of print.
Smith, Andrew Mark. "The action of therapeutic antibodies of varying geometry on lymphoma cells." Thesis, University of Winchester, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550213.
Повний текст джерелаLessard, Sarah, and not supplied. "Therapeutic interventions for lipidinduced insulin resistance in skeletal muscle: mechanisms of action." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070205.101938.
Повний текст джерелаScott, Brigitte Clare. "Analysis of the antioxidant action of potential food antioxidants and therapeutic agents." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338445.
Повний текст джерелаBates, Sarah H. "Investigation of potential intervention targets to improve insulin action: a therapeutic approach." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10980/.
Повний текст джерелаMilton, Lateshia B. "Engaging Parents of Black Students in Therapeutic Processes to Decrease Disciplinary Action." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7491.
Повний текст джерелаCholisoh, Zakky. "Viral infection in a murine model of allergic airways inflammation : actions of corticosteroids." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/58454/.
Повний текст джерелаMoss, Joe. "Anti-inflammatory actions of nutraceuticals : novel emerging therapies for atherosclerosis?" Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/111849/.
Повний текст джерелаSteketee, Pieter Christiaan. "Investigating the mode of action of AN5568, a novel therapeutic against African trypanosomiasis." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7478/.
Повний текст джерелаWoods, Margaret Annaliese. "Molecular mechanisms of action of therapeutic monoclonal antibodies on T lymphocytes in vitro." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627301.
Повний текст джерелаMykytyuk, O. P. "Therapeutic hypothermia in intensive cardiology: definition, mechanisms of action, safety and technical aspects." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18054.
Повний текст джерелаRODER, EMANUELA. "The complexity of therapeutic action in DBT: preliminary studies on process and outcome." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241311.
Повний текст джерелаDialectical Behavior Therapy (DBT; Linehan, 1993, 2014) is a structured, complex and comprehensive cognitive-behavioral treatment program for patients with Borderline Personality Disorder (BPD) and severe dysfunctional behaviors (repeated suicidal attempts, self-harm behaviors, relational instability, other impulsive behaviors). Up to now, DBT proved its effectiveness in several studies: suicide attempts and dysfunctional behaviors decreased, while emotional regulation and general functioning improved. The present research aimed at assessing the effectiveness of DBT and its mechanisms of action, evaluating both outcome and process dimensions. The first part of the thesis is dedicated to the presentation of the DBT model, examining its theoretical foundations, the agreements underlying the treatment, the modalities of therapeutic program, and the strategies of intervention. The second part of the thesis is an evaluation of the effectiveness of DBT, examining the course over time of the target variables. The study is longitudinal, single-blind, with a two-arm parallel design, conducted following the international guidelines for the outcome studies on intention-to-treat samples. DBT was compared with another treatment program comparable by patient type, objectives, and complexity of interventions. The sample was comprised by 95 outpatients, assigned to groups with the minimisation procedure and assessed every three months. Since the individual variability was expected to be consistent, Hierarchical Linear Models with random effects were used. Results showed that suicidality, self-harm, emotional and behavioral dysregulation decreased in both groups after one year; unconditional growth models indicated that subjects differed in the elevation and in the rate of change. Moreover, results on the completers’ subsample suggested that the group setting and the intensity of treatment could represent specific therapeutic mechanisms. The third part of the thesis is composed by process studies with a single-case design, in the strand of the process-outcome research: the empirical evaluation of two therapeutic couples, one with a favorable outcome and one with a partial outcome, was conducted. The patients were two young women with a diagnosis of Borderline Personality Disorder, different for personality profile and dysfunctional behaviors at the beginning of treatment; they followed a DBT standard program with the same therapist, a male experienced clinician. Sessions over the first year of treatment were examined (N1 = 38; N2 = 37). The technical and the relational dimensions of the therapeutic process were assessed and examined through a macroanalytic and microanalytic perspective. Results showed that some aspects are present in both couples: namely, the adherence to the treatment model and the attitude of the therapist oriented towards collaboration. On the other hand, specificities relating to each therapeutic couple emerged. In the treatment of the patient with positive outcomes, there was a globally positive relational climate; furthermore, therapist and patient can deal even with episodes of misunderstanding. Instead, in the treatment of the patient with partial outcomes, therapist and patient struggled to find an attunement and to work in synergy, remaining trapped in problematic relational patterns and without fully achieving the therapeutic objectives previously agreed. Taken together, results confirmed the effectiveness and the complexity of DBT. More specifically, they shed light on overlaps and differences between DBT and other theoretical models, in particular interventions promoting reflective functioning. Furthermore, the importance of a collaborative relationship between therapist and patient was confirmed. Overall, results suggested that mechanisms of action in DBT can be understood only in light of the dynamics of the therapeutic process in which they occur.
He, Lin. "Defining the role of the actin cytoskeleton in cellular uptake of cell penetrating peptides." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/94910/.
Повний текст джерелаZhu, Peili. "Anti-hepatocellular carcinoma mode and mechanism of action of antrodia camphorata mycelia." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/605.
Повний текст джерелаMac, Gabhann Liam. "Improving nurse patient therapeutic interactions in acute inpatient psychiatric care through participatory action research." Thesis, Swansea University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517752.
Повний текст джерелаSmith, Jennifer Ann. "An explorative study of child and youth care workers experiences of "lifespace therapeutic care"." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=init_4931_1178701317.
Повний текст джерелаCheung, Chun, and 張俊. "Mechanism of action of Xinmailong, a proprietary Chinese medicine for the treatment of chronic heart failure." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208582.
Повний текст джерелаpublished_or_final_version
Pharmacology and Pharmacy
Master
Master of Philosophy
Tian, Songhai, and 田松海. "Proteomic and pharmacological analyses of the mechanism of actions of anticancer gold(I) complexes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206471.
Повний текст джерелаpublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Butler, Elmien. "Poetic and therapeutic encounters with adolescents." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-08212007-123522.
Повний текст джерелаFinch, Krystal. "Adolescent Engagement in Home-Based Treatment: An Action Research Study." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5859.
Повний текст джерелаKojo, Kwofie Samuel. "Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_1790_1363781942.
Повний текст джерелаTo ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain greater understanding of HCV pathobiological mechanisms. The multitudes of metadata originating from HCV clinical trials as well as low and high-throughput experiments embedded in text corpora can be mined as data sources for the implementation of HCV-specific resources. HCV-customized resources may support the generation of worthy and testable hypothesis and reveal potential research clues to augment the pursuit of efficient diagnostic biomarkers and therapeutic targets. This research thesis report the development of two freely available HCV-specific web-based resources: (i) Dragon Exploratory System on Hepatitis C Virus (DESHCV) accessible via http://apps.sanbi.ac.za/DESHCV/ or http://cbrc.kaust.edu.sa/deshcv/ and (ii) Hepatitis C Virus Protein Interaction Database (HCVpro) accessible via 
http://apps.sanbi.ac.za/hcvpro/ or http://cbrc.kaust.edu.sa/hcvpro/. DESHCV is a text mining system implemented using named concept recognition and cooccurrence based 
approaches to computationally analyze about 32, 000 HCV related abstracts obtained from PubMed. As part of DESHCV development, the pre-constructed dictionaries of the 
Dragon Exploratory System (DES) were enriched with HCV biomedical concepts, including HCV proteins, name variants and symbols to enable HCV knowledge specific 
exploration. The DESHCV query inputs consist of user-defined keywords, phrases and concepts. DESHCV is therefore an information extraction tool that enables users to 
computationally generate association between concepts and support the prediction of potential hypothesis with diagnostic and therapeutic relevance. Additionally, users can 
retrieve a list of abstracts containing tagged concepts that can be used to overcome the herculean task of manual biocuration. DESHCV has been used to simulate previously 
reported thalidomide-chronic hepatitis C hypothesis and also to model a potentially novel thalidomide-amantadine hypothesis. HCVpro is a relational knowledgebase dedicated to housing experimentally detected HCV-HCV and HCV-human protein interaction information obtained from other databases and curated from biomedical journal articles. 
Additionally, the database contains consolidated biological information consisting of hepatocellular carcinoma (HCC) related genes, comprehensive reviews on HCV biology and drug development, functional genomics and molecular biology data, and cross-referenced links to canonical pathways and other essential biomedical databases. Users can retrieve enriched information including interaction metadata from HCVpro by using protein identifiers, gene chromosomal locations, experiment types used in detecting the interactions, PubMed IDs of journal articles reporting the interactions, annotated protein interaction IDs from external databases, and via &ldquo
string searches&rdquo
. The utility of HCVpro 
has been demonstrated by harnessing integrated data to suggest putative baseline clues that seem to support current diagnostic exploratory efforts directed towards vimentin. 
Furthermore, eight genes comprising of ACLY, AZGP1, DDX3X, FGG, H19, SIAH1, SERPING1 and THBS1 have been recommended for possible investigation to evaluate their 
diagnostic potential. The data archived in HCVpro can be 
utilized to support protein-protein interaction network-based candidate HCC gene prioritization for possible validation by experimental biologists. 
Ravenscroft, Gianina. "A therapeutic approach for the skeletal muscle a-actin based congenital myopathies." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0049.
Повний текст джерелаLEONARDI, GIUSEPPA. "Acting as therapeutic support in Parkinson's disease. A Field experiment." Doctoral thesis, Università degli studi di Catania, 2014. http://hdl.handle.net/20.500.11769/490593.
Повний текст джерелаIn the past, the clinical approach to Parkinson s disease focussed primarily on motor symptoms, whereas the current trend emphasises the importance of non-motor symptoms, thus moving towards a more complex type of assistance aimed at enhancing each patient s residual ability and, as far as possible, at rehabilitating their impaired daily activities. So, there is a growing amount of artistic activities that appear to positively influence the patients emotional and relational sphere as well as their and their family s quality of life (QoL). Over a period of 8 months, a group of patients with a moderate form of idiopathic Parkinson s disease, on stable L-dopa and L-dopa antagonists, together with a few family members, took part in a weekly theatre workshop culminating in a show given to the public. The patients were evaluated both before and at the end of the eight-month workshop using eight Assessment Scales indicating the state of progression of the disease (H&Y, UPDRS, PDQ8, PDSS, NMSS, FES, GFQ and MMSE). The results of these assessments were then compared to verify if the theatre workshop had had any influence and if so to what extent. The result analysis showed that modest improvements were associated with movement parameters, while parameters regarding memory, attention and concentration, quality of sleep and especially relational aspects were affected in a statistically significant manner, allowing us to say that the patients quality of life (QoL) clearly improved thanks to acting.
Leonardi, Giuseppa MAria Grazia. "Acting as therapeutic support in Parkinson's disease. A Field experiment." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1503.
Повний текст джерелаAlrumaih, Ali Mohammed S. "Early environments and neurobehavioural programming : therapeutic actions of antidepressants : neurobehavioural programming during development." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6317.
Повний текст джерелаAlrumaih, Ali M. S. "Early environments and neurobehavioural programming: Therapeutic actions of antidepressants. Neurobehavioural programming during development." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6317.
Повний текст джерелаMinistry of Defence, Prince Sultan Military College of Health Sciences and the Saudi Culture Bureau
Miller, Mark Russell. "The mechanism of action and therapeutic potential of S-nitrosothiols as novel nitric oxide donor drugs." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24981.
Повний текст джерелаGasper, Régis. "Infrared spectroscopy as a new tool for the screening of antitumoral agents inducing original therapeutic action." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210034.
Повний текст джерелаLa spectroscopie infrarouge est une technique d’absorption de la lumière fournit la signature chimique d’un échantillon. L’excellente qualité du signal rend possible son utilisation comme outil discriminant. En outre, cette technique d’analyse se démarque des autres par son caractère non destructif et la rapidité d’acquisition des données. Elle se révèlerait donc une méthode de choix pour effectuer du criblage de molécules en vue de la recherche de nouveaux agents thérapeutiques.
Dans un premier temps nous avons voulu évaluer la possibilité d’utiliser la spectroscopie infrarouge pour isoler la signature spectrale du mode d’action induit par des concentrations sub-létales de ouabaïne, un composé de la famille des cardénolides, sur une lignée tumorale de prostate. Nous avons montré que cette signature évolue au cours du temps et peut-être corrélée aux données biologiques décrites dans la littérature. Nous avons également mis en évidence pour la première fois une modification de la composition lipidique de la cellule. Cette altération a été caractérisée au cours du temps par spectrométrie de masse.
Nous avons ensuite voulu définir les limites de la méthode. La littérature souligne la diversité des modes d’action que peut induire un agent thérapeutique selon sa concentration. Nous avons montré que cette diversité se reflète sur le spectre infrarouge de cellules tumorales traitées à la ouabaïne en distinguant au moins deux modes d’action distincts, dépendant de la concentration en ouabaïne. Par ailleurs, nous avons montré que la confluence pouvait modifier significativement le spectre infrarouge d’une cellule. Neanmoins cette signature est unique et orthogonale à celle induite par la ouabaïne.
Finalement, nous avons évalué le potentiel de la spectroscopie infrarouge à distinguer des modes d’action induits par des molécules à la structure chimique proche. Nous avons montré qu’il était possible de caractériser spécifiquement chacun des modes d’action. D’autre part nous avons mis en évidence que les modes d’action de molécules issues d’une même classe d’agent thérapeutique conduisaient à des signatures spectrales similaires. Cette partie du travail souligne la possibilité d’utilisation de la spectroscopie infrarouge pour un classement objectif, uniquement basé sur leur mode d’action d’agents thérapeutiques potentiels.
Doctorat en Sciences agronomiques et ingénierie biologique
info:eu-repo/semantics/nonPublished
Seed, Alison. "Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure." Thesis, Connect to e-thesis, 2007. http://theses.gla.ac.uk/119/.
Повний текст джерелаM.D. thesis submitted to the Faculty of Medicine, Dept. of Medicine and Therapeutics, University of Glasgow, 2007. Includes bibliographical references. Print version also available.
Muwanga, Catherine. "An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3303_1184589097.
Повний текст джерелаIn South Africa, the crude aqueous extract from Hypoxis hemerocallidea is used by AIDS patients to treat opportunistic infections, such as tuberculosis. The rapid emergence of multidrug-resistant tuberculosis, and extreme drug resistant tuberculosis, in recent years, is a major threat to human health. The treatment of TB, nosocomial bacterial infections, and fungal infections is now a clinical challenge, especially in the immuno-compromised individual. There is a dire need for novel antibiotic alternatives with phytotherapies and plant-derived compounds as potentially promising alternatives. The main objective of this study was to investigate the antimycobacterial activity of Hypoxis hemerocallidea, a South African medicinal plant, using Mycobacterium smegmatis.
Brundula, Sodja Veronika. "Inhibiting T cell migration as a therapeutic strategy for Multiple Sclerosis, minocycline and its mechanisms of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/MQ55198.pdf.
Повний текст джерела