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Статті в журналах з теми "Therapeutic potential of anticancer immunotoxins"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Choudhary, Swati, Mrudula Mathew, and Rama S. Verma. "Therapeutic potential of anticancer immunotoxins." Drug Discovery Today 16, no. 11-12 (2011): 495–503. http://dx.doi.org/10.1016/j.drudis.2011.04.003.

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2

Ahmad, Zuhaida Asra, Swee Keong Yeap, Abdul Manaf Ali, Wan Yong Ho, Noorjahan Banu Mohamed Alitheen, and Muhajir Hamid. "scFv Antibody: Principles and Clinical Application." Clinical and Developmental Immunology 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/980250.

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To date, generation of single-chain fragment variable (scFv) has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional proteins having both antigen-binding capacity and marker activity can be obtained from transformed bacteria

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3

Oszajca, Katarzyna, Łukasz Wieteska, Magdalena Cybula, and Janusz Szemraj. "The assessment of prokaryotic addictive modules’ activity in the context of seeking novel immunotoxins." Postępy Polskiej Medycyny i Farmacji 5 (June 26, 2017): 59–63. http://dx.doi.org/10.5604/01.3001.0011.6195.

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Despite of the fact that current anticancer chemotherapeutics have many beneficial achievements, there is an urgent need for new efficient therapies. A new type of drugs which are extensively investigated are immunotoxinshybrid proteins that consist of cytotoxic component and second part which is responsible for selective binding to the receptors on tumor cells. Unfortunately, this group of therapeutics still has many drawbacks. There is a strong demand for research on a new substances and develo-ping targeted therapy strategies. In the present study we tested VapC toxin derived from prokaryot

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4

Stone, Marvin J. "Immunotoxins as Potential Anticancer Agents." Baylor University Medical Center Proceedings 3, no. 4 (1990): 35–37. http://dx.doi.org/10.1080/08998280.1990.11929736.

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5

Pincus, Seth H. "Therapeutic potential of anti-HIV immunotoxins." Antiviral Research 33, no. 1 (1996): 1–9. http://dx.doi.org/10.1016/s0166-3542(96)00995-3.

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6

Kawakami, Koji, Oumi Nakajima, Ryuichi Morishita, and Ryozo Nagai. "Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties." Scientific World JOURNAL 6 (2006): 781–90. http://dx.doi.org/10.1100/tsw.2006.162.

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Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. Among targeted cancer therapeutics, biologicals with targetable antibodies or ligands conjugated or fused to toxins or chemicals for direct cell-killing ability have been developed over the last 2 decades. These conjugated or fused chimeric proteins are termed immunotoxins or cytotoxic agents. Two agents, DAB389IL-2 (ONTAKTM) targeting the interleukin-2 receptor and CD33-c

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7

Weldon, John E., Laiman Xiang, Oleg Chertov, et al. "A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity." Blood 113, no. 16 (2009): 3792–800. http://dx.doi.org/10.1182/blood-2008-08-173195.

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Abstract Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38-kDa fragment of PE (PE38). The intoxication pathway of PE immunotoxins involves receptor-mediated internalization and trafficking through endosomes/lysosomes, during which the immunotoxin undergoes important proteolytic processing steps but must otherwise remain intact for eventual transport to the cytosol. We have investigated the proteolytic susceptibility of PE38 immunotoxins to lysosomal proteases and found

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8

Narbona, Javier, Rubén G. Gordo, Jaime Tomé-Amat та Javier Lacadena. "A New Optimized Version of a Colorectal Cancer-Targeted Immunotoxin Based on a Non-Immunogenic Variant of the Ribotoxin α-Sarcin". Cancers 15, № 4 (2023): 1114. http://dx.doi.org/10.3390/cancers15041114.

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Due to its incidence and mortality, cancer remains one of the main risks to human health and lifespans. In order to overcome this worldwide disease, immunotherapy and the therapeutic use of immunotoxins have arisen as promising approaches. However, the immunogenicity of foreign proteins limits the dose of immunotoxins administered, thereby leading to a decrease in its therapeutic benefit. In this study, we designed two different variants of non-immunogenic immunotoxins (IMTXA33αSDI and IMTXA33furαSDI) based on a deimmunized variant of the ribotoxin α-sarcin. The inclusion of a furin cleavage s

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9

Balalaeva, I. V., E. A. Sokolova, A. D. Puzhikhina, A. A. Brilkina, and S. M. Deyev. "Spheroids of HER2-Positive Breast Adenocarcinoma for Studying Anticancer Immunotoxins In Vitro." Acta Naturae 9, no. 1 (2017): 38–44. http://dx.doi.org/10.32607/20758251-2017-9-1-38-44.

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Tumor response to therapeutic treatment is largely determined by its heterogeneity and the presence of intercellular junctions, hindering the penetration of large molecules deep into the three-dimensional structure of the tumor. In that context, 3D in vitro tumor models such as cancer cell spheroids are becoming increasingly popular. We obtained spheroids of human breast adenocarcinoma SKBR-3 overexpressing the HER2 cancer marker. The toxicity of HER2-targeted immunotoxin 4D5scFv-PE40 against spheroids was shown to be several orders of magnitude lower compared to a monolayer cell culture. The

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10

Ruiz-de-la-Herrán, Javier, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes та Javier Lacadena. "Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins". Toxins 11, № 10 (2019): 593. http://dx.doi.org/10.3390/toxins11100593.

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Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immunotoxins have arisen as promising antitumor therapeutic agents. In this work, we describe the production and purification of two new immunoconjugates, based on RNase T1 and the fungal ribotoxin α-sarcin, with optimized properties for tumor treatment due to the inclusion of a furin cleavage site. Circular dichroism spectroscopy, ribonucleolytic activity s

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11

Sanz, Laura, Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Javier Lacadena, and Alberto Anel. "Antibody-Based Immunotoxins for Colorectal Cancer Therapy." Biomedicines 9, no. 11 (2021): 1729. http://dx.doi.org/10.3390/biomedicines9111729.

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Monoclonal antibodies (mAbs) are included among the treatment options for advanced colorectal cancer (CRC). However, while these mAbs effectively target cancer cells, they may have limited clinical activity. A strategy to improve their therapeutic potential is arming them with a toxic payload. Immunotoxins (ITX) combining the cell-killing ability of a toxin with the specificity of a mAb constitute a promising strategy for CRC therapy. However, several important challenges in optimizing ITX remain, including suboptimal pharmacokinetics and especially the immunogenicity of the toxin moiety. None

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12

Lee, Ji Won, Hyun Jung Kim, and Kyun Heo. "Therapeutic aptamers: developmental potential as anticancer drugs." BMB Reports 48, no. 4 (2015): 234–37. http://dx.doi.org/10.5483/bmbrep.2015.48.4.277.

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13

Toole, Bryan, Shibnath Ghatak, and Suniti Misra. "Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic." Current Pharmaceutical Biotechnology 9, no. 4 (2008): 249–52. http://dx.doi.org/10.2174/138920108785161569.

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14

Panigrahy, Dipak, Lucy Q. Shen, Mark W. Kieran, and Arja Kaipainen. "Therapeutic potential of thiazolidinediones as anticancer agents." Expert Opinion on Investigational Drugs 12, no. 12 (2003): 1925–37. http://dx.doi.org/10.1517/13543784.12.12.1925.

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15

Ying, Hua-Zhong, Chen-Huan Yu, Hao-Kun Chen, et al. "Quinonoids: Therapeutic Potential for Lung Cancer Treatment." BioMed Research International 2020 (April 7, 2020): 1–13. http://dx.doi.org/10.1155/2020/2460565.

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Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher

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16

Guerrero-Ochoa, Patricia, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, et al. "Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment." Biomedicines 10, no. 6 (2022): 1223. http://dx.doi.org/10.3390/biomedicines10061223.

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Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also known as the Tn antigen, expressed in a variety of tumor cell types. We first demonstrated the affinity of these immunotoxins for their antigen using surface plasmon resonance for the purified antigen and flow cytometry for the antigen expressed on the surface of living tumor cells. The induction of cell death of tumor cell lines of different

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17

Çetinkaya, Melisa, and Yusuf Baran. "Therapeutic Potential of Luteolin on Cancer." Vaccines 11, no. 3 (2023): 554. http://dx.doi.org/10.3390/vaccines11030554.

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Cancer is a global concern, as the rate of incidence is increasing each year. The challenges related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to cancer therapeutic research to discover alternative therapy strategies that are less toxic to normal cells. Among those studies, the use of flavonoids—natural compounds produced by plants as secondary metabolites for cancer therapy—has been a hot topic in cancer treatment. Luteolin, a flavonoid that has been present in many fruits, vegetables, and herbs, has been identified to exhibit numerous biological activi

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18

Ahmed, Salman, Haroon Khan, Michael Aschner, Hamed Mirzae, Esra Küpeli Akkol, and Raffaele Capasso. "Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects." International Journal of Molecular Sciences 21, no. 16 (2020): 5622. http://dx.doi.org/10.3390/ijms21165622.

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Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorati

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19

Bolhassani, Azam, and Farnaz Zahedifard. "Therapeutic live vaccines as a potential anticancer strategy." International Journal of Cancer 131, no. 8 (2012): 1733–43. http://dx.doi.org/10.1002/ijc.27640.

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20

Tovmasyan, Artak, Romulo S. Sampaio, Mary-Keara Boss, et al. "Anticancer therapeutic potential of Mn porphyrin/ascorbate system." Free Radical Biology and Medicine 89 (December 2015): 1231–47. http://dx.doi.org/10.1016/j.freeradbiomed.2015.10.416.

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21

Nandini, Pathak, Rani Anju, Singh Chhaya, Chauhan Neha, and Singh Raj. "Fermented Foods: The Pharmacological and Anticancer Therapeutic Potential." International Journal of Zoological Investigations 08, no. 02 (2022): 613–22. http://dx.doi.org/10.33745/ijzi.2022.v08i02.075.

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Globally, dietary and environmental changes have been recognized as major causes of noncommunicable diseases such as malignancies, with ongoing research on modifiable risk factors, including eating habits, estimating that 30–40% of cancer formation can be avoided with behavioral adjustments. According to estimates from the World Health Organization (WHO), cancer is the second leading cause of death worldwide, with 9.6 million fatalities projected in 2018. Cancer accounts for nearly 1 in every 6 deaths especially in females. In a survey of year 2019 within Indian subcontinent about 20% (one in

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22

Gallagher, W. J., and M. W. Burk. "Monoclonal antibody-ricin a chain conjugates (immunotoxins): Potential therapeutic agents for human colon carcinoma." Journal of Surgical Research 40, no. 2 (1986): 159–66. http://dx.doi.org/10.1016/0022-4804(86)90118-6.

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23

Lehman, H. P., U. Zangemeister-Wittke, E. J. Wawrzynczak, A. Collinson, R. Waibel, and R. A. Stahel. "Cytotoxicity and therapeutic potential of immunotoxins recognizing different antigens of small cell lung cancer." Lung Cancer 7 (January 1991): 186. http://dx.doi.org/10.1016/0169-5002(91)92044-j.

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24

Bannu, Saira M., Dakshayani Lomada, Surendra Gulla, Thummala Chandrasekhar, Pallu Reddanna, and Madhava C. Reddy. "Potential Therapeutic Applications of C-Phycocyanin." Current Drug Metabolism 20, no. 12 (2020): 967–76. http://dx.doi.org/10.2174/1389200220666191127110857.

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Background: Cancer and other disorders such as inflammation, autoimmune diseases and diabetes are the major health problems observed all over the world. Therefore, identifying a therapeutic target molecule for the treatment of these diseases is urgently needed to benefit public health. C-Phycocyanin (C-PC) is an important light yielding pigment intermittently systematized in the cyanobacterial species along with other algal species. It has numerous applications in the field of biotechnology and drug industry and also possesses antioxidant, anticancer, antiinflammatory, enhanced immune function

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25

Hussain, Hidayat, Ivan R. Green, Muhammad Saleem, Muhammad Liaquat Raza, and Mamona Nazir. "Therapeutic Potential of Iridoid Derivatives: Patent Review." Inventions 4, no. 2 (2019): 29. http://dx.doi.org/10.3390/inventions4020029.

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Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the poten

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26

Aaghaz, Shams, Vivek Gohel, and Ahmed Kamal. "Peptides as Potential Anticancer Agents." Current Topics in Medicinal Chemistry 19, no. 17 (2019): 1491–511. http://dx.doi.org/10.2174/1568026619666190125161517.

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Cancer consists of heterogeneous multiple cell subpopulation which at a later stage develop resistant phenotypes, which include resistance to pro-apoptotic stimuli and/or cytotoxic resistance to anticancer compounds. The property of cancerous cells to affect almost any part of the body categorizes cancer to many anatomic and molecular subtypes, each requiring a particular therapeutic intervention. As several modalities are hindered in a variety of cancers and as the cancer cells accrue varied types of oncogenic mutations during their progression the most likely benefit will be obtained by a co

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27

Hagerty, Brendan L., Guillaume J. Pegna, Jian Xu, Chin-Hsien Tai, and Christine Alewine. "Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors." Biomolecules 10, no. 7 (2020): 973. http://dx.doi.org/10.3390/biom10070973.

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Mesothelin (MSLN) is a cell surface glycoprotein normally expressed only on serosal surfaces, and not found in the parenchyma of vital organs. Many solid tumors also express MSLN, including mesothelioma and pancreatic adenocarcinoma. Due to this favorable expression profile, MSLN represents a viable target for directed anti-neoplastic therapies, such as recombinant immunotoxins (iToxs). Pre-clinical testing of MSLN-targeted iTox’s has yielded a strong body of evidence for activity against a number of solid tumors. This has led to multiple clinical trials, testing the safety and efficacy of the

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28

Szczepanek, Joanna, Monika Skorupa, and Andrzej Tretyn. "MicroRNA as a Potential Therapeutic Molecule in Cancer." Cells 11, no. 6 (2022): 1008. http://dx.doi.org/10.3390/cells11061008.

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Small noncoding RNAs, as post-translational regulators of many target genes, are not only markers of neoplastic disease initiation and progression, but also markers of response to anticancer therapy. Hundreds of miRNAs have been identified as biomarkers of drug resistance, and many have demonstrated the potential to sensitize cancer cells to therapy. Their properties of modulating the response of cells to therapy have made them a promising target for overcoming drug resistance. Several methods have been developed for the delivery of miRNAs to cancer cells, including introducing synthetic miRNA

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29

Mezo, Gabor, Marilena Manea, Ildiko Szabo, Borbala Vincze, and Magdolna Kovacs. "New Derivatives of GnRH as Potential Anticancer Therapeutic Agents." Current Medicinal Chemistry 15, no. 23 (2008): 2366–79. http://dx.doi.org/10.2174/092986708785909157.

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30

Kamran, Sareh, Ajantha Sinniah, Mahfoudh A. M. Abdulghani, and Mohammed Abdullah Alshawsh. "Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review." Cancers 14, no. 5 (2022): 1100. http://dx.doi.org/10.3390/cancers14051100.

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Анотація:

Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an an

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31

Teixeira, Thaiz Rodrigues, Gustavo Souza dos Santos, Lorene Armstrong, Pio Colepicolo, and Hosana Maria Debonsi. "Antitumor Potential of Seaweed Derived-Endophytic Fungi." Antibiotics 8, no. 4 (2019): 205. http://dx.doi.org/10.3390/antibiotics8040205.

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The marine environment presents a high biodiversity and a valuable source of bioactive compounds with therapeutic and biotechnological potential. Among the organisms present in marine environment, the endophytic fungi isolated from seaweed stand out. These microorganisms have aroused interest in the scientific community regarding its various activities such as antiviral, antimicrobial, antioxidant, photoprotective, cytotoxic, genotoxic, anti-inflammatory, and anticancer, besides establishing important ecological relations with its hosts. Anticancer molecules derived from marine natural sources

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32

Reang, Jurnal, Prabodh Chander Sharma, Vijay Kumar Thakur, and Jaseela Majeed. "Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer." Biomolecules 11, no. 8 (2021): 1130. http://dx.doi.org/10.3390/biom11081130.

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Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various developments to prevent and treat cancer, the side effects of anticancer drugs remain a major concern. Ascorbic acid is an essential vitamin required by our bodies for normal physiological function and also has antioxidant and anticancer activity. Although the body cannot synthesize ascorbic acid, it is abundant in nature through foods and other natural sources and also exists as a nutritional food supplement. In anticancer drug development, ascorbic acid has played an important role by inhibiting the d

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33

Alven, Sibusiso, Xhamla Nqoro, Buhle Buyana, and Blessing A. Aderibigbe. "Polymer-Drug Conjugate, a Potential Therapeutic to Combat Breast and Lung Cancer." Pharmaceutics 12, no. 5 (2020): 406. http://dx.doi.org/10.3390/pharmaceutics12050406.

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Cancer is a chronic disease that is responsible for the high death rate, globally. The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. The anticancer drugs are limited pharmacologically, resulting from the serious side effects, which could be life-threatening. Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. They transport therapeutic

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34

Lombrea, Adelina, Alexandra Denisa Scurtu, Stefana Avram, et al. "Anticancer Potential of Betulonic Acid Derivatives." International Journal of Molecular Sciences 22, no. 7 (2021): 3676. http://dx.doi.org/10.3390/ijms22073676.

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Анотація:

Clinical trials have evidenced that several natural compounds, belonging to the phytochemical classes of alkaloids, terpenes, phenols and flavonoids, are effective for the management of various types of cancer. Latest research has proven that natural products and their semisynthetic variants may serve as a starting point for new drug candidates with a diversity of biological and pharmacological activities, designed to improve bioavailability, overcome cellular resistance, and enhance therapeutic efficacy. This review was designed to bring an update regarding the anticancer potential of betulon

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35

Govindaraj, Jayamathi. "A review on the therapeutic potential of Banana flower." Bioinformation 18, no. 4 (2022): 349–53. http://dx.doi.org/10.6026/97320630018349.

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Banana (Musa paradisiaca) flower is rich in phytochemicals and exhibit antioxidant, anti-inflammatory, anticancer properties etc. The flower extract of banana showed promising therapeutic effects due to the presence of phytochemicals and minerals.

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36

Kronke, M., JM Depper, WJ Leonard, ES Vitetta, TA Waldmann, and WC Greene. "Adult T cell leukemia: a potential target for ricin A chain immunotoxins." Blood 65, no. 6 (1985): 1416–21. http://dx.doi.org/10.1182/blood.v65.6.1416.bloodjournal6561416.

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Abstract Adult T cell leukemia (ATL) is an almost uniformly fatal malignancy of mature T cells associated with human T cell leukemia/lymphoma virus type 1 (HTLV-1) infection. Cells from this leukemia are characterized by the expression of large numbers of receptors for interleukin 2 (IL- 2). In an attempt to prepare an immunotoxin with selective cytotoxicity for ATL cells, we conjugated anti-Tac, a monoclonal anti-IL-2 receptor antibody, to purified ricin A chains. Although unmodified anti-Tac had no effect on the protein synthesis of these cells, anti-Tac-ricin A chain conjugates produced hal

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37

殷, 方田. "Regulatory T Cells as Potential Therapeutic Targets for Anticancer Therapy." Advances in Clinical Medicine 12, no. 10 (2022): 9267–72. http://dx.doi.org/10.12677/acm.2022.12101340.

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38

G. Ranieri and G. Gasparini. "Angiogenesis and Angiogenesis Inhibitors: a New Potential Anticancer Therapeutic Strategy." Current Drug Target - Immune, Endocrine & Metabolic Disorders 1, no. 3 (2001): 241–53. http://dx.doi.org/10.2174/1568008013341073.

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39

Catanzaro, Elena, Cinzia Calcabrini, Eleonora Turrini, Piero Sestili, and Carmela Fimognari. "Nrf2: a potential therapeutic target for naturally occurring anticancer drugs?" Expert Opinion on Therapeutic Targets 21, no. 8 (2017): 781–93. http://dx.doi.org/10.1080/14728222.2017.1351549.

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40

Kuriakose, Robin K., Rakesh C. Kukreja, and Lei Xi. "Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8139861.

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Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy. Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries. The purpose of this review is to assess whether anthracycline chemotherapy exacerbates cardiotoxicity in patients with hypertension. A link between hypertension comorbidity and anthracycline-induced cardiotoxicity (AIC) was first suggested in 1979. Subsequent preclinical and clinical studies

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41

Alshehri, Mohammed M., Javad Sharifi-Rad, Jesús Herrera-Bravo, et al. "Therapeutic Potential of Isoflavones with an Emphasis on Daidzein." Oxidative Medicine and Cellular Longevity 2021 (September 9, 2021): 1–15. http://dx.doi.org/10.1155/2021/6331630.

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Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction

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42

Kumar, Rajnish, Chanchal Singh, Avijit Mazumder, et al. "Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review." Mini-Reviews in Medicinal Chemistry 22, no. 9 (2022): 1289–304. http://dx.doi.org/10.2174/1389557521666211001122118.

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Abstract: Cancer is one of the deadliest diseases in many developed and developing countries. Continuous efforts are required for designing better therapeutic agents for the treatment of cancer with more efficacy, selectivity, and less toxicity. The fused heterocyclic ring system has been identified by several researchers as a privileged structure that can be used as the basis for drug discovery in medicinal chemistry. The hetero-aromatic bicyclic ring system acts as a pharmacophore in a wide range of drugs with therapeutic potential. According to studies in the literature, various substituted

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43

Jin, Jun-O., Pallavi Singh Chauhan, Ananta Prasad Arukha, Vishal Chavda, Anuj Dubey, and Dhananjay Yadav. "The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles." Marine Drugs 19, no. 5 (2021): 265. http://dx.doi.org/10.3390/md19050265.

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Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associa

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44

Fakhri, Sajad, Sadaf Abdian, Seyed Zachariah Moradi, Blake E. Delgadillo, Carmela Fimognari, and Anupam Bishayee. "Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus." Marine Drugs 20, no. 10 (2022): 625. http://dx.doi.org/10.3390/md20100625.

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The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealin

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45

Hasan, Mohammad Raghibul, Bader Saud Alotaibi, Ziyad Mohammed Althafar, Ahmed Hussain Mujamammi, and Jafar Jameela. "An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”." Molecules 28, no. 3 (2023): 1193. http://dx.doi.org/10.3390/molecules28031193.

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In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Due to significant constraints with current treatments, natural compounds are being explored as potential alternatives. There are now around 30 natural compounds under clinical trials for the treatment of cancer. Tulsi, or Holy Basil, of the genus Ocimum, is one of the most widely available and cost-effective medicinal plants. In India, the tulsi plant has deep religious and medicinal significance. Tulsi essential oil contains a valuable source of bioactive compounds, such as camphor, eucalyptol, eugeno

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46

Palkina, Kseniia A., Daria A. Ipatova, Ekaterina S. Shakhova, Anastasia V. Balakireva, and Nadezhda M. Markina. "Therapeutic Potential of Hispidin—Fungal and Plant Polyketide." Journal of Fungi 7, no. 5 (2021): 323. http://dx.doi.org/10.3390/jof7050323.

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There is a large number of bioactive polyketides well-known for their anticancer, antibiotic, cholesterol-lowering, and other therapeutic functions, and hispidin is among them. It is a highly abundant secondary plant and fungal metabolite, which is investigated in research devoted to cancer, metabolic syndrome, cardiovascular, neurodegenerative, and viral diseases. This review summarizes over 20 years of hispidin studies of its antioxidant, anti-inflammatory, anti-apoptotic, antiviral, and anti-cancer cell activity.

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47

Dong, Wenjuan, Hu Wang, Hailin Liu, et al. "Potential of Black Phosphorus in Immune-Based Therapeutic Strategies." Bioinorganic Chemistry and Applications 2022 (July 11, 2022): 1–18. http://dx.doi.org/10.1155/2022/3790097.

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Black phosphorus (BP) consists of phosphorus atoms, an essential element of bone and nucleic acid, which covalently bonds to three adjacent phosphorus atoms to form a puckered bilayer structure. With its anisotropy, band gap, biodegradability, and biocompatibility properties, BP is considered promising for cancer therapy. For example, BP under irradiation can convert near-infrared (NIR) light into heat and reactive oxygen species (ROS) to damage cancer cells, called photothermal therapy (PTT) and photodynamic therapy (PDT). Compared with PTT and PDT, the novel techniques of sonodynamic therapy

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48

Liubota, R. V., Zh P. Yakovets, R. I. Vereshchako, M. F. Anikusko, and I. I. Liubota. "Clinical significance of anticancer vaccines (literature review)." Practical oncology 4, no. 2 (2021): 14–24. http://dx.doi.org/10.22141/2663-3272.4.2.2021.238669.

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During the past few decades, the advances in cancer immunotherapy have revived interest in the potential use of vaccines for the malignant tumor treatment. Tumor-associated antigens, which are abnormally expressed by tumor cells, are of decisive importance in the development of anticancer vaccines. Through the stimulation of immunological memory, therapeutic anticancer vaccines can result in long-term remission or healing patients. Therapeutic anticancer vaccines due to the potential safety, specificity and duration of effect can become an alternative to or increase the effectiveness of existi

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Jo, Hyein, Kyeonghee Shim, and Dooil Jeoung. "The Potential of Senescence as a Target for Developing Anticancer Therapy." International Journal of Molecular Sciences 24, no. 4 (2023): 3436. http://dx.doi.org/10.3390/ijms24043436.

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Senescence occurs in response to various stimuli. Senescence has attracted attention because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also promotes tumorigeneses and therapeutic resistance. Since senescence can induce therapeutic resistance, targeting senescence may help to overcome therapeutic resistance. This review provides the mechanisms of senescence induction and the roles of the senescence-associated secretory phenotype (SASP) in various life processes, including therapeutic resistance and tumorigenesis. The SASP exerts pro-tumorigenic or antit

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Matos, Cristina P., Yasemin Yildizhan, Zelal Adiguzel, et al. "New ternary iron(iii) aminobisphenolate hydroxyquinoline complexes as potential therapeutic agents." Dalton Transactions 48, no. 24 (2019): 8702–16. http://dx.doi.org/10.1039/c9dt01193e.

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