Дисертації з теми "Therapeutic modality for cancer"
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Pozniak, John. "Systemic Delivery of microRNA as a Therapeutic Modality to Treat Cancer." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367939186.
Повний текст джерелаMcCarthy, Alexandra Leigh. "A rebellious distemper : a Foucaultian history of breast cancer to 1900." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16030/1/Alexandra_McCarthy_Thesis.pdf.
Повний текст джерелаMcCarthy, Alexandra Leigh. "A Rebellious Distemper: A Foucaultian History of Breast Cancer to 1900." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16030/.
Повний текст джерелаWalker, Teneille. "Therapeutic Drugs in Cancer." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1722.
Повний текст джерелаWang, Chao. "Integrative Analysis of Multi-modality Data in Cancer." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429791373.
Повний текст джерелаWall, Richard Andrew. "Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301761.
Повний текст джерелаMartin, Aditi Pandya. "Therapeutic drugs in cancer and resistance." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1717.
Повний текст джерелаQuinn, Bridget A. "Novel Therapeutic Strategies for Pancreatic Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4671.
Повний текст джерелаKurtyka, Courtney A. "Novel Therapeutic Strategies in Lung Cancer." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5363.
Повний текст джерелаYoung, Jennifer Denise. "Imaging and therapeutic radiotracers for prostate cancer." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/imaging-and-therapeutic-radiotracers-for-prostate-cancer(4822a0bb-f8a4-4738-bd61-23bb1b500e8d).html.
Повний текст джерелаSalem, Ahmed. "Validating non-invasive therapeutic lung cancer biomarkers." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/validating-noninvasive-therapeutic-lung-cancer-biomarkers(edeb97f1-b1d4-43a3-bafb-8c7e1fa9d8c7).html.
Повний текст джерелаJerome, Hannah. "Outcomes of cancer bereavement therapeutic support groups." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1574714/.
Повний текст джерелаElaskalani, Omar. "Platelet-cancer Crosstalk: Mechanisms and Therapeutic Implications." Thesis, Curtin University, 2019. http://hdl.handle.net/20.500.11937/77186.
Повний текст джерелаFunk, Marcia Sue Moffatt. "A survey of occupational therapy practitioners' interest in therapeutic horseback riding as a treatment modality." FIU Digital Commons, 1997. http://digitalcommons.fiu.edu/etd/3427.
Повний текст джерелаDevlin, Kathleen Marie. "The effects of client and therapist variables on therapeutic modality selection: Family vs. individual therapy." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186379.
Повний текст джерелаYouniss, Fatma. "MULTI – MODALITY MOLECULAR IMAGING OF ADOPTIVE IMMUNE CELL THERAPY IN BREAST CANCER." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3323.
Повний текст джерелаKhan, Tanweera S. "New Diagnostic and Therapeutic Approaches in Adrenocortical Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243.
Повний текст джерелаMd, Tohid Siti Farah. "Synthesis of potential cancer therapeutic and diagnostic agents." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/54438/.
Повний текст джерелаChalfant, Cheryl Lynn. "Design guidelines for therapeutic gardens serving cancer patients." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1231344.
Повний текст джерелаDepartment of Landscape Architecture
Chaneton, Barbara Julieta. "Targeting cancer cell metabolism as a therapeutic strategy." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5762/.
Повний текст джерелаJiang, Shan. "Netrin-3, a novel therapeutic target in cancer." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1344.
Повний текст джерелаThe proteins of the netrin family have been characterized mainly during embryonic development, as axonal guidance factors. However, these proteins also play a role in other mechanisms, including certain diseases. Netrin-1 is thus a recognized therapeutic target in oncology since molecules to block its activity are currently being developed. However, some members of this family have yet to be characterized. We were able to demonstrate that a strong expression of one of these factors was correlated with a poor prognosis for patient survival, in two cancer diseases. We hypothesized that this factor could be a survival protein that contributes to the aggressiveness of cancer cells
Sherret, John, and Joshua Coleman. "Small Cell Medullary Thyroid Cancer: A Therapeutic Dilemma." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/57.
Повний текст джерелаForsberg, Ole. "Generation of Therapeutic T Cells for Prostate Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100506.
Повний текст джерелаLee, Kristy. "Targeting Copper: A Therapeutic Strategy In Lymphoma." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/294030.
Повний текст джерелаLee, W. M. Anne, and 李詠梅. "Therapeutic benefits of concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290677.
Повний текст джерелаTate, Tyler, and Tyler Tate. "Dual Modality Optical Coherence Tomography and Multispectral Fluorescence Imaging for Ovarian Cancer Detection." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/623156.
Повний текст джерелаBosco, Emily E. "RB suppressor modifies the therapeutic response of breast cancer." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1147202417.
Повний текст джерелаTitle from electronic thesis title page (viewed . May 17, 2006). Includes abstract. Keywords: Retinoblastoma Tumor Suppressor; Breast Cancer; E2F; Tamoxifen; anti-estrogen resistance; DNA damage; cell cycle checkpoint. Includes bibliographical references.
Schwartz, Timothy R. "Therapeutic single-stranded oligonucleotides in gene repair and cancer." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 172 p, 2008. http://proquest.umi.com/pqdweb?did=1459919021&sid=13&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Повний текст джерелаMaddocks, Matthew. "Therapeutic exercise in cancer cachexia : exploring approaches and outcomes." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11112/.
Повний текст джерелаFemel, Julia. "Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229572.
Повний текст джерелаAgrawal, Vibhuti. "Dissecting the molecular mechanisms of therapeutic resistance in cancer." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112493.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Therapeutic resistance continues to be a persistent challenge in medical oncology. In clinical settings, resistance can occur at the beginning of treatment, or may be acquired after an initial clinical response to the therapy. Several mechanisms of drug resistance have been described in cancer, including alterations in the drug transport and metabolism process, mutations in drug-target, activation of bypass signaling pathways, inhibition of cell-death pathways, and induction of an epithelial to mesenchymal transition (EMT) in response to cytotoxic or targeted therapies. In this study, I have investigated the molecular mechanisms underlying ZEB 1-induced EMT and established a new computational framework that uses inter-animal heterogeneity to identify drivers responsible for variable phenotypic responses across different animals. EMT describes a cell-state switching process wherein epithelial cells lose their tight cell-cell junction contacts, and acquire the ability to migrate and invade the surrounding stroma to enter into blood circulation. Given the widespread role of EMT in drug resistance, it is imperative to identify therapeutic strategies to inhibit this transition. To identify druggable targets to block EMT progression, and therefore overcome EMT-mediated therapeutic resistance, I studied the effects of ZEB 1 expression on cellular signaling networks. By quantifying changes in tyrosine phosphorylation at different time points during ZEB 1-induced EMT, I found that Src family kinases (SFKs) were activated within 24 hours of ZEB 1 expression. Inhibition of SFKs blocked not only ZEB 1-induced EMT, but also EMT initiated by TGFp- and EGF signaling pathways in both breast and NSCLC cell-lines. SFK inhibition also prevented EGFR inhibitor-induced EMT and drug resistance in NSCLC cells both in vitro and in vivo. Mechanistically, SFK activation stabilized ZEBI by promoting ERK1/2-mediated phosphorylation on three serine residues, S583, S646, and S679. Consequently, MEK inhibition phenocopied the effects of blocking SFK activity with regards to decreasing stability of ZEB 1 and inhibiting ZEB 1-induced EMT. These results provide a new therapeutic application of SFK inhibitors as a potential anti-EMT therapy, to enhance the susceptibility of cancer cells to chemo- or targeted therapies. In the second part of this thesis, I have described a computational framework that leverages inter-animal heterogeneity to identify molecular mechanisms underlying variable phenotypic responses across different animals. Substantial inter-animal variability in phenotypes within the same treatment group, limits our ability to draw conclusions or gain meaningful insights about a biological process by simply averaging the data. To identify molecular drivers for heterogeneous phenotypic responses, I have established a method where each animal is considered as an individual entity whose phenotypic response is dependent on the state of its underlying signaling networks. As a proof of concept, I have used this method to successfully predict the resistance mechanisms of CDK4/6 inhibitor, palbocilib in two GBM PDX and one MPNST PDX models. The GBM6 model activated EGFR signaling upon treatment with palbociclib whereas the GBM22 and MPNST3 models activated SFKs and PDGFRa signaling in resistant tumors. Across all three PDX tumor models, treatment with combination therapies, consisting of palbociclib and an inhibitor targeting the activated bypass signaling pathway, substantially prolonged survival of mice. Thus, these results suggest that inter-animal variability can be used as a tool to predict drivers for a specific phenotypic response across different treatment conditions.
by Vibhuti Agrawal.
Ph. D.
Larkin, James Michael George. "Modelling hyperacute rejection as a therapeutic approach to cancer." Thesis, Institute of Cancer Research (University Of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415089.
Повний текст джерелаHicks, Mellissa. "Signaling Networks as Possible Therapeutic Implications in Breast Cancer." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405945861.
Повний текст джерелаYassen, Mohammed Omar Abdelaziz [Verfasser]. "Human Cytomegalovirus (HCMV)-based Therapeutic Cancer Vaccines / Mohammed Yassen." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1218077360/34.
Повний текст джерелаHamed, Hossein. "MDA-7/IL-24; A PROMISING CANCER THERAPEUTIC AGENT." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2847.
Повний текст джерелаWard, Nathan Patrick. "Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6778.
Повний текст джерелаFilipovic, Aleksandra. "Nicastrin as a novel therapeutic target in breast cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/14694.
Повний текст джерелаYassen, Mohammed [Verfasser]. "Human Cytomegalovirus (HCMV)-based Therapeutic Cancer Vaccines / Mohammed Yassen." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1218077360/34.
Повний текст джерелаSu, Hsin-Yuan. "Therapeutic Potential of EGFR Derived Peptides in Breast Cancer." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293486.
Повний текст джерелаAbel, Mark Joshua. "Novel therapeutic and diagnostic ultrasound techniques in cancer management." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47909.
Повний текст джерелаDudakovic, Amel. "Geranylgeranyl diphosphate synthase as a novel cancer therapeutic target." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/795.
Повний текст джерелаGross, Brett Patrick. "Therapeutic vaccination for the treatment of metastatic breast cancer." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6119.
Повний текст джерелаThomas, Beverley Jayne. "Gene therapy of melanoma : therapeutic and pharmaceutical investigations." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338377.
Повний текст джерелаUitterhoeve, Apollonia Léonie Joséphine. "Radiotherapy and Cisplatin: outcome of combined modality treatment in non-small cell lung cancer." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/47061.
Повний текст джерелаLam, Chi-leung David, and 林志良. "Oncogenic mutations as biomarkers and therapeutic targets in lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207610.
Повний текст джерелаpublished_or_final_version
Medicine
Master
Doctor of Medicine
Matthewson, Kenneth. "Studies on therapeutic neodymium YAG laser endoscopy." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241407.
Повний текст джерелаCarrington, Simon. "Polyamine conjugates with potential as therapeutic targets." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268208.
Повний текст джерелаKarst, Alison Marie. "Novel therapeutic targeting of apoptosis and survival pathways in melanoma." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2473.
Повний текст джерелаJarman, Paul J. "Mono and dinuclear ruthenium complexes as anti-cancer therapeutic leads." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/12213/.
Повний текст джерелаMakhani, Kiran, and Kiran Makhani. "Mechanism of Action of ERBB Decoy Cancer Therapeutic Peptide SAH5." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626139.
Повний текст джерела