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Статті в журналах з теми "Tau seeding"
Andrés-Benito, Pol, Margarita Carmona, Mónica Jordán, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antoni del Rio, and Isidro Ferrer. "Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum." International Journal of Molecular Sciences 23, no. 2 (January 10, 2022): 718. http://dx.doi.org/10.3390/ijms23020718.
Повний текст джерелаWu, Ruozhen, Jianlan Gu, Dingwei Zhou, Yunn Chyn Tung, Nana Jin, Dandan Chu, Wen Hu, et al. "Seeding-Competent Tau in Gray Matter Versus White Matter of Alzheimer’s Disease Brain." Journal of Alzheimer's Disease 79, no. 4 (February 16, 2021): 1647–59. http://dx.doi.org/10.3233/jad-201290.
Повний текст джерелаFerrer, Isidro, Maria Victoria Zelaya, Meritxell Aguiló García, Margarita Carmona, Irene López‐González, Pol Andrés‐Benito, Laia Lidón, Rosalina Gavín, Paula Garcia‐Esparcia, and José Antonio Rio. "Relevance of host tau in tau seeding and spreading in tauopathies." Brain Pathology 30, no. 2 (August 27, 2019): 298–318. http://dx.doi.org/10.1111/bpa.12778.
Повний текст джерелаHolmes, B. B., J. L. Furman, T. E. Mahan, T. R. Yamasaki, H. Mirbaha, W. C. Eades, L. Belaygorod, N. J. Cairns, D. M. Holtzman, and M. I. Diamond. "Proteopathic tau seeding predicts tauopathy in vivo." Proceedings of the National Academy of Sciences 111, no. 41 (September 26, 2014): E4376—E4385. http://dx.doi.org/10.1073/pnas.1411649111.
Повний текст джерелаHolth, Jerrah K., Sarah K. Fritschi, Chanung Wang, Nigel P. Pedersen, John R. Cirrito, Thomas E. Mahan, Mary Beth Finn, et al. "The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans." Science 363, no. 6429 (January 24, 2019): 880–84. http://dx.doi.org/10.1126/science.aav2546.
Повний текст джерелаRobert, Aiko, Michael Schöll, and Thomas Vogels. "Tau Seeding Mouse Models with Patient Brain-Derived Aggregates." International Journal of Molecular Sciences 22, no. 11 (June 7, 2021): 6132. http://dx.doi.org/10.3390/ijms22116132.
Повний текст джерелаPolanco, Juan Carlos, Yevhen Akimov, Avinash Fernandes, Adam Briner, Gabriel Rhys Hand, Marloes van Roijen, Giuseppe Balistreri, and Jürgen Götz. "CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau." Life Science Alliance 6, no. 1 (October 31, 2022): e202201689. http://dx.doi.org/10.26508/lsa.202201689.
Повний текст джерелаAbskharon, Romany, Paul M. Seidler, Michael R. Sawaya, Duilio Cascio, Tianxiao P. Yang, Stephan Philipp, Christopher Kazu Williams, et al. "Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease." Journal of Biological Chemistry 295, no. 31 (June 3, 2020): 10662–76. http://dx.doi.org/10.1074/jbc.ra120.013638.
Повний текст джерелаLeyns, Cheryl E. G., Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J. Koscal, Hong Jiang, Melissa Manis, et al. "TREM2 function impedes tau seeding in neuritic plaques." Nature Neuroscience 22, no. 8 (June 24, 2019): 1217–22. http://dx.doi.org/10.1038/s41593-019-0433-0.
Повний текст джерелаRidler, Charlotte. "Tau seeding starts early in the entorhinal cortex." Nature Reviews Neurology 14, no. 7 (May 24, 2018): 380. http://dx.doi.org/10.1038/s41582-018-0016-9.
Повний текст джерелаДисертації з теми "Tau seeding"
Pollack, Saskia Julie. "Self-assembly and seeding capabilities of an Alzheimer's disease associated fragment of tau." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/80073/.
Повний текст джерелаLindberg, Max. "Fluorescent fusion proteins as probes to characterize tau fibril polymorphism". Thesis, Linköpings universitet, Kemi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158263.
Повний текст джерелаShaffer, Oliver Jacob. "Impact of planting date and seeding rate on grain and forage yields of wheat in Texas." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2417.
Повний текст джерелаZallot, Rémi. "Identification et caractérisation d'une lipase exprimée pendant l'hydrolyse des réserves chez Arabidopsis thaliana." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21840/document.
Повний текст джерелаIn germinating seedlings of Arabidopsis thaliana, fat storage breakdown is initiated by lipases. A protein capable to bind to a lipase inhibitor was identified from an extract of rape seedlings and its amino acid sequence found to resemble that of known lipases. Transient expression of the Arabidopsis orthologous gene led to a 100-fold increase in lipase activity in Nicotiana bethamiana leaves. Taken together, these data strongly suggest that this protein is indeed a lipase. In vivo localization studies using a GFP fusion protein in Nicotiana benthamiana as a transcient expression host showed a peroxisomal localization. In Arabidopsis, the gene coding for this lipase was found to be mainly expressed in seedlings during fat storage breakdown. Most lipase activity was abolished in germinating seedlings of an Arabidopsis mutant for this gene. These data suggest that this lipase is likely involved in the breakdown of fat storage in germinating seedlings of Arabidopsis. However, oil mobilization was not affected in Arabidopsis mutant plants. This might suggest that the effect of the mutation could be compensated for by other lipases
Kalia, Bhanu. "Mining the Aegilops tauschii gene pool: evaluation, introgression and molecular characterization of adult plant resistance to leaf rust and seedling resistance to tan spot in synthetic hexaploid wheat." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/18934.
Повний текст джерелаGenetics Interdepartmental Program
Bikram S. Gill
Leaf rust, caused by fungus Puccinia triticina, is an important foliar disease of wheat worldwide. Breeding for race-nonspecific resistant cultivars is the best strategy to combat this disease. Aegilops tauschii, D genome donor of hexaploid wheat, has provided resistance to several pests and pathogens of wheat. To identify potentially new adult plant resistance (APR) genes, 371 geographically diverse Ae. tauschii accessions were evaluated in field with leaf rust (LR) composite culture of predominant races. Accessions from Afghanistan only displayed APR whereas both seedling resistance and APR were common in the Caspian Sea region. Seventeen accessions with high APR were selected for production of synthetic hexaploid wheat (SHW), using ‘TetraPrelude’ and/or ‘TetraThatcher’ as tetraploid parents. Six SHWs were produced and evaluated for APR to LR and resistance to tan spot at seedling stage. Genetic analysis and mapping of APR introgressed from accession TA2474 was investigated in recombinant inbred lines (RIL) population derived from cross between SHW, TA4161-L3 and spring wheat cultivar, ‘WL711’. Genotyping-by-sequencing approach was used to genotype the RILs. Maximum disease severity (MDS) for LR was significantly correlated among all experiments and APR to LR was highly heritable trait in this population. Nine genomic regions significantly associated with APR to LR were QLr.ksu-1AL, QLr.ksu-1BS, QLr.ksu-1BL.1, QLr.ksu-1BL.2, QLr.ksu-2DS, QLr.ksu-2DL, QLr.ksu-5AL, QLr.ksu-5DL and QLr.ksu-6BL. Association of QLr.ksu-1BL.1 with marker Xwmc44 indicated this locus could be slow-rusting APR gene, Lr46/Yr29. QTLs detected on 2DS, 2DL and 5DL were contributed by TA4161-L3 and are novel, along with QLr.ksu-5AL. Tan spot, caused by necrotrophic fungus, Pyrenophora tritici-repentis, has recently emerged as a damaging disease of wheat worldwide. To identify QTLs associated with resistance to Race 1 of P. tritici-repentis, F[subscript]2:3 population derived from cross between SHW, TA4161-L1 and winter wheat cultivar, ‘TAM105’ was used. Two major effect QTLs, QTs.ksu-1AS.1 and QTs.ksu-7AS were significantly associated with tan spot resistance and contributed by TA4161-L1. QTs.ksu-7AS is a novel QTL and explained 17% of the phenotypic variation. Novel QTLs for APR to LR and tan spot identified in SHWs add new variation for broadening the gene pool of wheat and providing resources for breeding of durable resistant cultivars.
Calafate, Sara de Sa Cesariny. "Tauopathy seeding models as a platform for Tau aggregation and clearance study." Master's thesis, 2012. http://hdl.handle.net/10316/25016.
Повний текст джерелаA doença de Alzheimer é a forma de demência mais prevalente. Quando a proteína Tau perde a conformação correcta forma agregados, começando por originar oligomeros e mais tarde fibrilas de grandes dimensões dando origem a trancas neurofibrilares. Alguns estudos sugerem que estas espécies são transmitidas através das áreas do cérebro danificando o circuito neuronal. Para parar o avanço da doença muitos trabalhos têm em foco o desenvolvimento de terapias que manipulam a fosforilação desta proteína, a estabilização dos microtubulos e a indução da degradação da Tau. Para desenvolver terapias que impedem a agregação ou que induzam a degradação da Tau, é necessário desenvolver modelos que recapitulam a agregação. Neste trabalho “seeding effect” foi a estratégia utilizada para induzir a agregação da hTauP301L. No presente trabalho dois modelos in vitro baseados nesta estratégia foram utilizados – um desenvolvido em linhas celulares e outro em culturas neuronais primarias – onde se observou a hiper-fosforilação e agregação da Tau. A co-expressão da GSK3β aumentou a fosforilacao na ser202/thr205 na Tau solúvel e insolúvel, mas apenas a sua expressão não foi suficiente para induzir agregação. Em culturas neuronais primárias a fosforilação e agregação da Tau aumentam ao longo do tempo. A inibição da Hsp90 reduziu os níveis de Tau totais de e fosforilados no epitopo AT8, dando importância a esta estratégia como um potencial mecanismo para degradação da Tau.Com este trabalho produzimos dois modelos onde estudos em nucleação, agregação e transmissão sináptica da Tau poderão ser feitos. Estes modelos são ferramentas válidas para o desenvolvimento de fármacos para AD e outras Tauopatias
Alzheimer Disease is the most prevalent dementia. Abnormal folding of Tau leads to generation of aggregated Tau species like oligomers and further NFTs. Toxic Tau species were suggested to spread trough human brain and damage the neuronal circuit. To halt disease progression a noteworthy development in therapies based on phosphorylation modulation, Microtubule stabilization and enchantment of Tau clearance have been done. To develop therapies against Tau aggregation and aggregates clearance, the build up of models that recapitulates Tau pathology are required. In the following work the “seeding” strategy was used to achieve aggregation of hTauP301L. We worked with two in-vitro seeding models – cellular and primary neuronal- where phosphorylated insoluble hTauP301L is present. GSK3β was shown to increase ser202/thr205 phosphorylation in soluble and insoluble hTauP301L expressed in QBI but was not sufficient to induce aggregation alone. In primary neuronal seeding model tau aggregation and phosphorylation was increased over-time. Hsp90 inhibition was found to reduce total and AT8 immuno-reactive hTauP301L levels, emerging as a potential drug for Tau clearance. With this work we provide two models to study the mechanisms behind tau nucleation, aggregation, and trans-synaptic spreading. These models are valuable tools for the development of drugs for AD and Tauopathies.
Kennett, Raymond Matthew. "The Evaluation of High Tannin Cotton Lines for Resistance to Rhizoctonia solani and Pythium aphanidermatum." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7621.
Повний текст джерелаWhiting, Elizabeth Cameron. "The effects of nursery incurred tap-root wounds on growth of Douglas-fir seedlings /." 1987. http://hdl.handle.net/1957/13254.
Повний текст джерелаStanislav, Scott Michael. "A Field-Scale Assessment of Soil-Specific Seeding Rates to Optimize Yield Factors and Water Use in Cotton." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8201.
Повний текст джерелаZhang, Yulan. "Salmonella Infection on Arabidopsis Seedlings Requires Both Host and Pathogen Factors." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8934.
Повний текст джерелаКниги з теми "Tau seeding"
Whiting, Elizabeth Cameron. The effects of nursery incurred tap-root wounds on growth of Douglas-fir seedlings. 1987.
Знайти повний текст джерелаЧастини книг з теми "Tau seeding"
Maina, Katherine N., Caroline Smet-Nocca, and Gal Bitan. "Using FRET-Based Biosensor Cells to Study the Seeding Activity of Tau and α-Synuclein." In Methods in Molecular Biology, 125–45. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2597-2_10.
Повний текст джерелаHai-Jew, Shalin. "Capturing the Gist(s) of Image Sets Associated with Chinese Cities through Related Tags Networks on Flickr®." In Social Media Listening and Monitoring for Business Applications, 245–315. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0846-5.ch011.
Повний текст джерелаТези доповідей конференцій з теми "Tau seeding"
Faleyev, D. G., K. K. Boguspaev, E. G. Faleyev, and J. J. Myrzagaliev. "The effect of biohumus on the growth of seedlings of Scorzonera tau-saghyz Lipsch. et Bosse in the laboratory." In Fifth International Conference of CIS IHSS on Humic Innovative Technologies «Humic substances and living systems». CLUB PRINT ltd., 2019. http://dx.doi.org/10.36291/hit.2019.faleyev.060.
Повний текст джерелаArora, Rahul D. "Inpatient pharmacologic management of malignant bowel obstruction." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685360.
Повний текст джерелаPIMOKHOVA, Lyudmila, German YaGOVENKO, Zhanna TSARAPNEVA, and Nina Kharaborkina. "Impact of efficient protective chemicals on seeds yield of white lupin." In Multifunctional adaptive feed production 27 (75). ru: Federal Williams Research Center of Forage Production and Agroecology, 2022. http://dx.doi.org/10.33814/mak-2022-27-75-65-72.
Повний текст джерелаЗвіти організацій з теми "Tau seeding"
Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, June 2013. http://dx.doi.org/10.32747/2013.7699847.bard.
Повний текст джерелаEshel, Amram, Jonathan P. Lynch, and Kathleen M. Brown. Physiological Regulation of Root System Architecture: The Role of Ethylene and Phosphorus. United States Department of Agriculture, December 2001. http://dx.doi.org/10.32747/2001.7585195.bard.
Повний текст джерелаChamovitz, Daniel A., and Albrecht G. Von Arnim. eIF3 Complexes and the eIF3e Subunit in Arabidopsis Development and Translation Initiation. United States Department of Agriculture, September 2009. http://dx.doi.org/10.32747/2009.7696545.bard.
Повний текст джерела