Дисертації з теми "T-ray"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "T-ray".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Mickan, Samuel Peter. "T-ray biosensing /." Title page, table of contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phm6253.pdf.
Повний текст джерелаFerguson, Bradley Stuart. "Three dimensional T-Ray inspection systems /." Title page, Table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phf3521.pdf.
Повний текст джерелаMeinhold, Mitchell W. 1972. "Aligned T-gate, fabrication using X-ray lithography." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/43303.
Повний текст джерелаIncludes bibliographical references (leaves 55-56).
by Mitchell Meinhold.
M.S.
Gregory, Scott G. "T Tauri stars : mass accretion and X-ray emission." Thesis, St Andrews, 2007. http://hdl.handle.net/10023/336.
Повний текст джерелаKöhl, Martin [Verfasser], and T. [Akademischer Betreuer] Baumbach. "Analysis of nanostructures based on diffraction of X-ray radiation / Martin Köhl. Betreuer: T. Baumbach." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1065732163/34.
Повний текст джерелаLiddington, R. C. "The origins of co-operativity in haemoglobin : An X-ray analysis of the liganded T state." Thesis, University of York, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372760.
Повний текст джерелаLazarev, Sergey [Verfasser], and Baumbach G. [Akademischer Betreuer] T. "X-ray investigation of defects in III-nitrides and their alloys / Sergey Lazarev. Betreuer: G. T. Baumbach." Karlsruhe : KIT-Bibliothek, 2013. http://d-nb.info/1059803151/34.
Повний текст джерелаUnlu, Caglar. "Task Parallelism For Ray Tracing On A Gpu Cluster." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609325/index.pdf.
Повний текст джерелаBeasley, Daniel. "3D quantitative elemental mapping of biological tissues using proton induced X-ray emission tomography (PIXE-T) and on/off-axis scanning transmission ion microscopy tomography (STIM-T)." Thesis, University of Surrey, 2006. http://epubs.surrey.ac.uk/843466/.
Повний текст джерелаWeinhardt, Venera [Verfasser], and T. [Akademischer Betreuer] Baumbach. "3-D imaging based on hard x-ray grating interferometry: theory, development and application / Venera Weinhardt. Betreuer: T. Baumbach." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1054397279/34.
Повний текст джерелаMarles-Wright, Jon. "Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families." Thesis, University of Oxford, 2005. http://ora.ox.ac.uk/objects/uuid:1f6d480a-a641-4778-9ff0-ece1b2d38d5c.
Повний текст джерелаKaufholz, Marthe [Verfasser], and T. [Akademischer Betreuer] Baumbach. "Monitoring the film formation during sputter deposition of vanadium carbide by in situ X-ray reflectivity measurements / Marthe Kaufholz. Betreuer: T. Baumbach." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1066736936/34.
Повний текст джерелаTandl, Dominique [Verfasser], Gerhard [Akademischer Betreuer] Thiel, and Alexander [Akademischer Betreuer] Löwer. "X-ray irradiation triggers via ROS production a canonical Ca2+-dependent immune response in T-lymphocytes / Dominique Tandl ; Gerhard Thiel, Alexander Löwer." Darmstadt : Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1228537410/34.
Повний текст джерелаPidchenko, Ivan [Verfasser], and T. [Akademischer Betreuer] Vitova. "Characterization of structural properties of U and Pu in model systems by advanced synchrotron based X-ray spectroscopy / Ivan Pidchenko. Betreuer: T. Vitova." Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1100529543/34.
Повний текст джерелаColombo, Salvatore. "Radiation hydrodynamic and magnetohydrodynamic models of plasma flows accreting onto Classical T Tour Stars." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS608.
Повний текст джерелаIn this work we investigated the mass accretion process in CTTSs. We studied if accretion from the disk to the star might occur as a result of a coronal activity, and we analyzed the structure and the dynamics of the accretion column plasma in the impact regions. We developed numerical models that describe: a star-disk system subject to the effects of a coronal activity in proximity of the disk surface; the impact of an accretion column onto the surface of a CTTS.We investigated if an intense coronal activity due to flares that occur close to the accretion disk may perturb the stability of the inner disk, disrupt the inner part of the disk, and possibly trigger accretion phenomena with mass accretion rates comparable with those observed in CTTSs. To this end, we modeled a magnetized protostar surrounded by an accretion disk through 3D magnetohydrodynamics simulations.As it concerns the study of accretion impacts, we analyzed the effects of radiation emerg-ing from the shock-heated plasma at the base of accretion columns on the structure of the pre- shock downfalling material. To this end, we upgraded a module handling the local thermodynamic equilibrium (LTE) radiation-hydrodynamics (RHD) in the PLUTO code , which we have extended to handle also the non-LTE regime. Then, we investigated if a significant absorption of radiation arising from the shock heated plasma occurs in the unshocked downfalling material, and if it leads to a pre-shock heating of the accreting gas
Funke, Peter M. "X-Ray crystal structure of a ribosomal protein S6, S15, S18 : rRNA complex from T. thermophilus, and investigation of conformational changes in 16S rRNA fragments from B. stearothermophilus during ribonucleoprotein assembly." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73391.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 74-80).
The X-ray crystallographic structure of a fragment of the 30S ribosomal subunit from Thermus thermophilus containing ribosomal proteins S6, S15, S18, and a minimal rRNA binding site (T4 RNP) containing two different three-helix junctions was solved to 2.6 A. The protein S15 contains four bundled a-helices and binds the rRNA along the minor groove of helix 22 and contacts elements of both three-helix rRNA junctions. The protein S6 contains a four-stranded [beta]-sheet buttressed by two a-helices and forms a heterodimer with S18, a poorly structured protein with both a-helices and random coil elements. The S6:S18 heterodimer binds across the helix 22, helix 23, helix 23a RNA junction and makes no direct contacts to S15. Time-resolved fluorescence resonance energy (trFRET) methods were used to assess conformational changes in both RNA three-helix junctions in separate model systems from Bacillus stearothermophilus. Helix 21 and helix 23 are shown to stack coaxially onto each end of helix 22 in the absence of either S15 or divalent magnesium ions. S15 and magnesium are both shown to stabilize a reorganization of the helix 20, helix 21, helix 22 RNA junction, whereby helix 20 rotates proximal to helix 22. Single-pair fluorescence resonance energy transfer (spFRET) methods were used to show a conformational change in individual RNA molecules in solution upon addition of either S15 or magnesium. We also observe individual subpopulations of unbound and bound RNA as we titrate S15 around the known protein dissociation constant Kd. We incorporate our structural information into a more detailed model of cooperative binding between S15 and the S6:S18 heterodimer during T4 RNP formation, and address the implica
by Peter M. Funke.
S.M.
Kebapci, Basak. "Development Of High Performance Uncooled Infrared Detector Materials." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613070/index.pdf.
Повний текст джерелаCnudde, Sara Elizabeth. "The x-ray crystallographic structures of the angiogenesis inhibitor angiostatin bound to a peptide from the group A streptococcal surface protein PAM and the metal-bound conantokins con-G and con-T[K7gamma]." Diss., Connect to online resource - MSU authorized users, 2007.
Знайти повний текст джерелаZhang, Chong. "Recovery of cerebrovascular morphodynamics from time-resolved rotational angiography." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/51921.
Повний текст джерелаDurante la última década se ha dado un creciente interés en la evaluación del movimiento de la pared vascular en aneurismas cerebrales. Éste hecho ha sido motivado en gran medida por la relación existente entre dicha motilidad y sus condiciones biomecánicas, pudiendo éstas llegar a ser útiles en la predicción del riesgo de ruptura del aneurisma cerebral analizado. De este modo, de ésta cuantificación, se podría llegar a derivar un indicador indirecto del estado e integridad de la pared vascular. Sin embargo, la gran mayoría de los índices morfológicos utilizados en la actualidad para predecir crecimiento y ruptura de aneurismas cerebrales no consideran los cambios que se producen en el tiempo a lo largo del ciclo cardíaco. Esto se debe a que dichos índices se obtienen a partir de modalidades de imagen que no proporcionan suficiente resolución espacial y/o temporal para obtener información dinámica del aneurisma, cuyo rango de variación se espera sea similar o inferior a la resolución de la imagen. Entre las técnicas de imagen vascular disponibles en la actualidad, la angiografía rotacional 3D (3DRA) y la angiografía de substracción digital (DSA) son las que ofrecen la mayor resolución espacial (y temporal). De todos modos, aún utilizando imágenes de estas modalidades, el análisis objetivo de pequeñas diferencias de forma y movimiento en los vasos cerebrales de un individuo a lo largo de un ciclo cardíaco es difícil, si no imposible para un operador humano utilizando únicamente medidas cualitativas guiadas por inspección visual. Por lo tanto, la disponibilidad de herramientas robustas para el análisis morfodinámico de la vasculatura cerebral resulta necesaria. En este contexto, la investigación de esta tesis se concentra en el desarrollo de técnicas para estimar, cuantificar y analizar el movimiento de las paredes de los vasos cerebrales, con particular énfasis en el movimiento de la pared en aneurismas, utilizando las modalidades indicadas anteriormente. En líneas generales, esta tesis presenta tres contribuciones principales: 1) una primera metodología de estimación y modelado morfodinámico de vasos cerebrales a lo largo de un ciclo cardíaco, utilizando una técnica de registrado de imágenes 2D-3D; 2) una metodología extendida para proporcionar una estimación robusta y eficiente del movimiento de las paredes de los vasos cerebrales para su evaluación clínica y posterior modelado biomecánico de dichas paredes; 3) un estudio sobre una población de pacientes que demuestra la validez de las técnicas desarrolladas en la práctica clínica, a través del análisis en imágenes de 3DRA y DSA. Cada una de estas contribuciones ha sido publicada o se encuentra en fase de revisión en revistas internacionales indexadas.
Cavarelli, Jean. "Etude cristallographique d'un complexe nucleoproteique forme entre l'aspartyl-trna synthetase de levure et l'acide ribonucleique de transfert specifique de l'acide aspartique." Strasbourg 1, 1987. http://www.theses.fr/1987STR13160.
Повний текст джерелаSmila-Castro, Ornella. "X-ray absorption spectroscopy studies of electrochemical processes." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3766/.
Повний текст джерелаRodríguez, Sanmartín Daniel. "Smart piezoelectric devices for X-ray optics applications." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3193/.
Повний текст джерелаPowrie, Fiona Margaret. "Functional analysis of rat T cell subsets." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238190.
Повний текст джерелаMi, Na. "Synchrotron X-ray studies of atmospheric pitting corrosion of stainless steel." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4558/.
Повний текст джерелаCrocker, Glenn. "A study of surface receptors on rat T lymphocytes." Thesis, University of Oxford, 1991. http://ora.ox.ac.uk/objects/uuid:5c74a70b-1f5e-4c78-904f-7c4ff1b543a8.
Повний текст джерелаLaw, Deborah Ann. "The role of the CD2 antigen in T-lymphocyte interactions." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236192.
Повний текст джерелаArthur, R. P. "In vitro functional studies of rat T helper cell heterogeneity." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355759.
Повний текст джерелаHernández-Hoyos, Gabriela. "Studies of the T cell lineage in the BB rat." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627489.
Повний текст джерелаGhahari, Seyed Majid. "In situ synchrotron x-ray characterisation and modelling of pitting corrosion of stainless steel." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3269/.
Повний текст джерелаVanpeene, Victor. "Étude par tomographie RX d'anodes à base de silicium pour batteries Li-ion." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEI023/document.
Повний текст джерелаBecause of its theoretical specific capacity ten times higher than that of graphite currently used as active anode material for Li-ion batteries, silicon can play an important role in increasing the energy density of these systems. However, the alloying reaction set up during its lithiation results in a high volume expansion of silicon (~300% compared with only ~10% for graphite) leading to the structural degradation of the electrode, which is significantly affecting its cycling behavior. Understanding in detail these phenomena of degradation and developing strategies to limit their impact on the functioning of the electrode are of undeniable interest for the scientific community of the field. The objective of this thesis work was first to develop a characterization technique adapted to the observation of these degradation phenomena and to draw the necessary information to optimize the formulation of silicon-based anodes. In this context, we have used X-ray tomography which has the advantage of being a non-destructive analytical technique allowing in situ and 3D monitoring of the morphological variations occurring within the electrode during its operation. This technique has been adapted to the case study of silicon by adjusting the analyzed electrode volumes, the spatial resolution and the temporal resolution to the phenomena to be observed. Appropriate image processing procedures were applied to extract from these tomographic analyzes as much qualitative and quantitative information as possible on their morphological variation. In addition, this technique could be coupled to X-ray diffraction to complete the understanding of these phenomena. We have shown that the use of a carbon paper structuring 3D current collector makes it possible to attenuate the morphological deformations of an Si anode and to increase their reversibility in comparison with a conventional copper current collector of plane geometry. We have also shown that the use of graphene nanoplatelets as a conductive additive to replace carbon black can form a conductive network more able to withstand the large volume variations of silicon. Finally, the X-ray tomography allowed studying dynamically and quantitatively the cracking and delamination of an Si electrode deposited on a copper collector. We have thus demonstrated the significant impact of a process of "maturation" of the electrode to minimize these deleterious phenomena of cracking-delamination of the electrode
Dorneles, Cristina Manera. "Tomografia computadorizada de t?rax em crian?as : podemos fazer um exame com a dose semelhante a de um raio x de t?rax e sem anestesia?" Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/7688.
Повний текст джерелаApproved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-10-10T13:01:18Z (GMT) No. of bitstreams: 1 Disserta??o Cristina Manera.pdf: 1861857 bytes, checksum: 55d02acda533fde326a0ac0a092db0ed (MD5)
Made available in DSpace on 2017-10-10T13:03:42Z (GMT). No. of bitstreams: 1 Disserta??o Cristina Manera.pdf: 1861857 bytes, checksum: 55d02acda533fde326a0ac0a092db0ed (MD5) Previous issue date: 2016-08-31
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Objective: To evaluate the technical quality of low-dose computed tomography without contrast and without the use of anesthesia in the diagnosis of lung diseases in children Materials and Methods: It reviewed 86 chest CT scans performed due to clinical indications of acute or chronic inflammatory lung diseases, cancer or congenital malformations in patients from 1 to 18 years of age who were subjected to a low dose of radiation dose bellow the dose recommended by the ALARA and using interactive image reconstruction filters performed without the use of anesthesia or sedation. The exams will be evaluated by two reviewers and age, gender, the radiation dose, image quality and image noise will be assessed. Image analysis will be quantitative. The variables will be the outside Roi diameter of trachea divided by the Roi of trachea, the percentage of axial images with motion artifacts, and identification of the tracheal, the main and segmental bronchi? 20 segments, the main and lobar pulmonary arteries and the ascending aorta artery. The presence of pleural effusion and the identification of paratracheal and subcarinal lymph node chains will also be assessed. Data will be analyzed by for mean, standard deviation and the correlation of the data will be analyzed by tests of Pearson and Spearman, considering significant a p<0.05. Results: The average age of the patients was 5.5 years. LSD as well with the LID, LSE and LIE were displayed in all tests. The middle lobe in almost all (n = 85) apical segment and the medial basilar segment were seen in almost all of the scans (n = 84). The aorta and pulmonary arteries were distinguished on all tomography examinations. The percentage of images with motion artifact introduced an average of 0.8 with IC: 0-2.9 (P25-P75) with p < 0.001. The noise of the image showed an average of 45.5 with 12.4DP. How much ROI the trachea and main bronchi were seen in all the CT scans. The image quality was considered excellent and blurring that didn't compromise the evaluation in almost all the tests. The DLP in mGy dose presented an average of 27.5 with DP ? 11.1. Conclusion: The dose used was significantly lower than the one used in children and allowed the visualization of lung structures in almost all patients, enabling the final diagnosis of cystic fibrosis, bronchiolitis and congenital malformations without difficulty of diagnosis by image artifact
Objetivo: Avaliar a qualidade t?cnica da Tomografia Computadorizada de baixa dose sem contraste e sem anestesia no diagn?stico de doen?as pulmonares em crian?as e adolescentes. Materiais e m?todos: Estudo descritivo retrospectivo em que foram analisadas 86 Tomografias Computadorizadas de t?rax em pacientes pedi?tricos e adolescentes. Os exames foram realizados por indica??o clinica de suspeita de patologias pulmonares com baixa dose de radia??o e com filtro de reconstru??o interativa da imagem sem uso de anestesia ou seda??o. Estes exames foram analisados por dois avaliadores independentes e as vari?veis medidas foram idade, o sexo, a dose de radia??o, a qualidade da imagem, o ru?do de imagem, o ROI externo dividido pelo um ROI na traqueia, identifica??o da traqueia, dos br?nquios principais e segmentares-20 segmentos , das art?rias pulmonares principais e lobares, aorta ascendente, presen?a de derrame pleural, cadeias linfonodais paratraqueais e subcarinal Todas as imagens tamb?m foram medidas quanto a artefato de movimento e foram descritos em porcentagem comparando com o total de imagens. Os dados foram analisados com m?dia, desvio padr?o. Para a an?lise da correla??o foram usados os ?ndices de Pearson e de Spearman considerando um p < 0,01 como significativo. Resultados: A visualiza??o da traqueia e dos br?nquios principais foi poss?vel em 100% dos exames. Os linfonodos paratraqueais e os subcarinais foram visto em todos os exames na bronquiolite e na malforma??o cong?nita. Os lobos superior, m?dio e inferior direito foram visualizados na totalidade das Tomografias Computadorizadas com baixa dose de radia??o nos pacientes com fibrose c?stica e bronquiolite. Na malforma??o cong?nita os lobos superior e inferior direitos foram visualizados em todos exames. Os lobos superior e inferior esquerdos foram identificados em todas as an?lises por TC. Os segmentos apicais foram vistos em 100% das imagens na FC, BO e malforma??o cong?nita.O segmento basilar apical foi visto em todas as imagens na FC. As art?rias aorta e pulmonar foram distinguidas no total dos exames Em nenhum exame houve comprometimento da qualidade da imagem. Na malforma??o cong?nita a percentagem de imagem com excelente qualidade e borramento leve sem comprometimento da avalia??o foram encontradas em todos os exames tomogr?ficos. A porcentagem de artefato de imagem foi de 0,3% na fibrose c?stica, 1,3 % na bronquiolite e 1,1% na malforma??o cong?nita. Conclus?o A dose utilizada foi significativamente menor do que a utilizada em crian?as e permitiu a visualiza??o das estruturas pulmonares em quase todos os pacientes possibilitando o diagn?stico final da fibrose c?stica, da bronquiolite e das malforma??es cong?nitas sem dificuldade de diagn?stico por artefato de imagem.
Wiefelspütz, Achim [Verfasser]. "Frequenzevaluation von Ras- und Influenza-spezifischen T-Zellen bei Pankreaskarzinompatienten / Achim Wiefelspütz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023581000/34.
Повний текст джерелаCatchpole, Brian. "Antigen presentation to autoreactive T cells in experimentally-induced arthritis in the rat." Thesis, Royal Veterinary College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314347.
Повний текст джерелаCASTEDO, MARIA(DOLORES. "Fonction des cellules t cd4#+ autoreactives dans deux modeles d'autoimmunite chez le rat." Paris 7, 1993. http://www.theses.fr/1993PA077234.
Повний текст джерелаGreen, Harry M. Bjorkman Pamela Jane. "Novel methods for studying Ras/Erk MAP kinase signaling in developing T cells /." Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-10242005-165226.
Повний текст джерелаFujiki, Masato. "Induced Tolerance to Rat Liver Allografts Involves the Apoptosis of Intragraft T Cells and the Generation of CD4[+]CD25[+]Foxp3[+] T Regulatory Cells." Kyoto University, 2011. http://hdl.handle.net/2433/142102.
Повний текст джерелаXystrakis, Emmanuel. "Caractérisation des réponses alloréactives des lymphocytes T séparés en fonction de l'expression de l'antigène CD45RC : rôle potentiel dans l'allogreffe de moelle osseuse." Toulouse 3, 2004. http://www.theses.fr/2004TOU30002.
Повний текст джерелаTrinquand, Amélie. "Leucémies Aigues Lymphoblastiques T et signalisation TCR." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05S008.
Повний текст джерелаT-cell acute lymphoblastic leukemias (T-ALL) are rare lymphoid neoplasms characterized by the proliferation of T lymphoblasts arrested at specific stages of maturation. Leukemic transformation of maturating thymocytes is caused by a multistep pathogenesis involving numerous genetic abnormalities that drive normal T cells into uncontrolled cell growth and clonal expansion. Depending on immunogenetic, T-ALLs are classified in 3 groups: immature, cortical (blocked around b-selection) and mature (CD3/TCR+) T-ALL. My work was to determine if activation and TCR signalling are involved in the biology of this disease. We demonstrate in T-ALL that, irrespective of the complex oncogenic abnormalities underlying tumor progression, experimentally induced, persistent TCR signalling has anti-leukemic properties and enforces a molecular and phosphoproteomic program resembling thymic negative selection, a major developmental event in normal T cell development. Using mouse models of T-ALL, we show that induction of TCR signalling by high affinity self-peptide/MHC or treatment with monoclonal antibodies to the CD3e chain (anti-CD3) causes massive leukemic cell death. Importantly, anti-CD3 treatment hampered leukemogenesis in mice transplanted with either mouse or patient-derived T-ALLs. These data provide a strong rationale for targeted therapy based on anti-CD3 treatment of TCR-expressing T-ALL patients and demonstrate that endogenous developmental checkpoint pathways are amenable to therapeutic intervention in cancer cells. Besides, I studied frequency and prognostic impact of anomalies concerning pre-TCR/TCR signalling in a large cohort of adult T-ALL included in GRAALL trials. RAS/MAPK and PI3K/PTEN/AKT pathways are involved in pre-TCR/TCR signalling and are reported as deregulated in pediatric T-ALL. I identified deletion/mutation loss-of-function of PTEN (12%) and activating mutations of KRAS/N-RAS (11%) in 23% of patients. These anomalies predict poor outcome and abrogate the good prognosis of NOTCH1/FBXW7 mutations. We proposed a purely genetic stratification of patients based on N/F/RAS/PTEN status, identifying low-risk patients (51%) with N/F mutations without RAS/PTEN anomalies and high-risk patients (49%) composed by the remaining cohort. This stratification will be used for the next protocol of adult-T-ALL
Lanzarotti, Nina. "Régulation de la réponse immunitaire T par l’apoptose et hyperactivation de la voie RAS." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T038/document.
Повний текст джерелаLymphocytes apoptosis is essential in maintaining homeostasis and avoiding abnormal proliferation. When defective, autoimmune diseases as the Autoimmune LymphoProliferative Syndrome (ALPS), due to mutations of the death receptor FAS, can occur. Several pathways are important actors influencing the apoptosis cascade, including the RAS proto-oncogene signaling. The RAS Associated Lymphoproliferative Disease (RALD) is a newly described entity, similar to ALPS but with RAS mutations instead of FAS mutations, enlightening the primary role of RAS in apoptosis regulation. Interestingly, the same RAS mutations as observed in RALD are also the cause of a malignant proliferation, the Juvenile Myelo Monocytic Leukemia (JMML). In the case of JMML, RAS mutations can lead either to a mild (LS-JMML) or a severe (S-JMML) phenotype. Thus, three different phenotypes can be caused by the same oncogenic RAS mutations. In order to better understand and characterize the influence of oncogenic RAS mutations in lymphocytes’ apoptosis we studied it in patients presenting with RALD, LS-JMML and JMML. We showed that isolated RAS hyperactivity is not sufficient to induce an immune deregulation. Additional factors are required to do so. These factors influence both mitochondrial and extrinsic apoptosis pathways at a post-transcriptional level. They are due to probable genetic events, and their identification can lead to new therapeutic strategies. Furthermore, activated lymphocytes’ in vitro apoptosis assessment can help differentiating the three phenotypes and thus facilitate prognosis prediction
Oliveira, Marinez Josefina Casarotto de. "Desenvolvimento de t?cnica de resson?ncia nuclear magn?tica r?pida e de respira??o livre em pacientes com fibrose c?stica." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/7760.
Повний текст джерелаApproved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-12-04T12:45:28Z (GMT) No. of bitstreams: 1 Tese-MC.pdf: 2529108 bytes, checksum: d7557f03bd9245db7376252ca33303d0 (MD5)
Made available in DSpace on 2017-12-04T12:47:32Z (GMT). No. of bitstreams: 1 Tese-MC.pdf: 2529108 bytes, checksum: d7557f03bd9245db7376252ca33303d0 (MD5) Previous issue date: 2017-07-31
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Introduction-objective: Cystic fibrosis is the most common genetic disease in the Caucasian population. The reduction in life expectancy is due to progressive lung disease, characterized by severe changes in the pulmonary structure, more precisely, bronchiectasis and air catabolization. Computed tomography of the chest is considered the most sensitive method to monitor lung disease in cystic fibrosis. The main disadvantage is the patient's exposure to radiation. Magnetic resonance imaging of the chest, a radiation-free technique, has been introduced as an alternative to computed tomography. Magnetic resonance has been compared to computed tomography in several studies using various sequences, but none have used the combined sensing, parallel imaging, and golden-angle radial sampling technique. The aim of this study was to evaluate the combined golden-angle radial technique of magnetic resonance imaging in patients with cystic fibrosis in relation to conventional magnetic resonance imaging and computed tomography of the chest. Cystic fibrosis has been compared to computed tomography in several studies using various sequences, but none have used the combined sensing, parallel imaging, and golden-angle radial sampling technique. The aim of this study was to evaluate the combined radial-angle golden-angle technique of magnetic resonance imaging in patients with cystic fibrosis in relation to conventional magnetic resonance imaging and computed tomography of the chest. Methods: Computed tomography and magnetic resonance of the chest were performed in 29 patients with cystic fibrosis who were followed at the pediatric pulmonology outpatient clinic of the S?o Lucas Hospital of the Pontifical Catholic University of Rio Grande do Sul. The Cartesian K-space sampling and, after the free-breathing magnetic resonance techniques, using the Golden_Angle Radial Sparse Parallel technique. Magnetic resonance imaging and computed tomography of the chest were evaluated by two independent observers using the Helbich-Bhalla score. Intraclass correlation coefficient and Bland-Altman analysis were used to assess agreement and reproducibility in the Helbich-Bhalla severity score. No patient was sedated or used contrast medium. Results: Intraclass correlation coefficients and the Bland-Altman graphical model between the Helbich-Bhalla scores and the evaluated methods, computed tomography, magnetic resonance and free breating magnetic resonance , showed very strong correlations in all comparisons of the total scores (ICCCT -RM = 97%, ICCCT-FB-RM = 96% and ICCCT-FB-RM = 99%). The association of the Helbich-Bhalla score of both computed tomography and magnetic resonance with pulmonary function tests were significant, mainly in relation to the severity of bronchiectasis and thickening of the bronchial walls. Conclusion: This study demonstrated that the new technique of free-breathing magnetic resonance and combination of compressed sensing, parallel imaging and radial golden-angle sampling, showed a good concordance with computed tomography in the assessment of pulmonary alterations in cystic fibrosis. The combined golden-angle radial technique can be used in clinical practice to monitor fibrocystic lung disease, and demonstrates particular value for patients who can not hold their breath during the examination.
Introdu??o-objetivo: Fibrose c?stica ? a doen?a gen?tica mais comum na popula??o caucasiana. A redu??o da expectativa de vida ? devido ? doen?a pulmonar progressiva, caracterizada por mudan?as severas na estrutura pulmonar, mais precisamente, bronquiectasias e alcaponamento de ar. A tomografia computadorizada de t?rax ? considerada o m?todo mais sens?vel para monitorar a doen?a pulmonar na fibrose c?stica. A principal desvantagem ? a exposi??o do paciente ? radia??o. A resson?ncia magn?tica de t?rax, t?cnica livre de radia??o, tem sido introduzida como uma alternativa ? tomografia computadorizada. A resson?ncia magn?tica tem sido comparada ? tomografia computadorizada em v?rios estudos usando v?rias sequ?ncias, mas, nenhuma utilizou a t?cnica de sensoriamento comprimido, imagem paralela e amostragem golden-angle radial combinada. O objetivo deste estudo foi avaliar a t?cnica de golden-angle radial combinada de resson?ncia magn?tica de t?rax em pacientes com fibrose c?stica em rela??o ? tomografia computadorizada e a resson?ncia magn?tica convencional de t?rax. M?todos: Foram realizados exames de tomografia computadorizada e resson?ncia magn?tica de t?rax em 29 pacientes com fibrose c?stica que eram acompanhados no ambulat?rio de pneumologia pedi?trica do Hospital S?o Lucas da Pontif?cia Universidade Cat?lica do Rio Grande do Sul. Os exames, foram realizados utilizando, primeiro, a amostragem de K-espa?o cartesiano e, ap?s, as t?cnicas de resson?ncia magn?tica com respira??o livre, utilizando a t?cnica Golden_Angle Radial Sparse Parallel. As imagens de resson?ncia magn?tica e tomografia computadorizada de t?rax foram avaliadas por dois observadores independentes utilizando o escore de Helbich-Bhalla. Coeficiente de correla??o intraclasse e an?lise de Bland-Altman foram usados para avaliar a concord?ncia e a reprodutibilidade no escore de severidade de Helbich-Bhalla. Nenhum paciente foi sedado ou usado meio de contraste. Resultados: Os coeficientes de correla??o intraclasse e o modelo gr?fico de Bland-Altman entre os escores de Helbich-Bhalla e os m?todos avaliados, tomografia computadorizada, resson?ncia magn?tica e resson?ncia magn?tica de respira??o livre, evidenciaram, em todas as compara??es dos escores totais, correla??es muito fortes (ICCCT-RM = 97%; ICCCT-FB-RM = 96% e ICCCT- FB-RM=99%). A associa??o do escore de Helbich-Bhalla, tanto da tomografia computadorizada como das imagens de resson?ncia magn?tica, com os testes de fun??o pulmonar foram significativas, principalmente, em rela??o ? severidade das bronquiectasias e espessamento das paredes br?nquicas. Conclus?o: Este estudo demonstrou que a nova t?cnica de resson?ncia magn?tica com respira??o livre e combina??o de sensoriamento comprimido, imagem paralela e amostragem golden-angle radial, mostrou uma boa concord?ncia com a tomografia computadorizada na avalia??o das altera??es pulmonares na fibrose c?stica. A t?cnica de golden-angle radial combinada pode ser utilizada na pr?tica cl?nica para acompanhamento de doen?a pulmonar fibroc?stica, e demonstra particular valor para os pacientes que n?o conseguem suspender a respira??o durante o exame.
Hansson, Johan. "Activation and differentiation of cytotoxic T lymphocytes identification of district CTL subsets in the rat /." Lund : Dept. of Tumor Immunology, the Wallenberg Laboratory, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39158589.html.
Повний текст джерелаBraun, Monika. "Einfluss des onkogenen RAS-Signalweges auf die Tumorerkennung durch zytotoxische T-Lymphozyten und NK-Zellen." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-96419.
Повний текст джерелаScudamore, Charles Henry. "Allograft enhancement in a rat heart transplant model : effect of T and B cell immunization." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24916.
Повний текст джерелаSurgery, Department of
Medicine, Faculty of
Graduate
Infante, Elvira. "Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/role-of-rap-and-rho-gtpases-in-tacute-lymphoblastic-leukaemia-cell-adhesion-and-migration(e1c1aff6-96a7-4dc6-9ee5-355bb41b01ee).html.
Повний текст джерелаMoreau, Thierry. "Etude structurale et fonctionnelle du T-kininogène de rat (Thiostatine) et de ses fragments protéolytiques." Tours, 1988. http://www.theses.fr/1988TOUR4003.
Повний текст джерелаKamsu, Ngounve Jeanine. "Cyto-architecture de la formation hippocampique du rat et de l’homme par IRM 7 T." Caen, 2013. http://www.theses.fr/2013CAEN3168.
Повний текст джерелаEarly detection of lesions of the hippocampal formation in diseases such as epilepsy, Alzheimer's disease, depression remains a challenge for current clinical MRI scanners. The hippocampal formation is a cerebral structure with a multi-layered organization and is also crossed by an original excitatory synaptic circuit. Given that specific layers of the hippocampus are affected early in the development of some pathologies, such as the stratum radiatum and lacunosum moleculare of CA1 region in Alzheimer's disease or the granular cell layer of the dentate gyrus with depression, it has become imperative to obtain more precise images of the hippocampal structure in order to improve our understanding and the early detection of microstructural changes which could occur in the hippocampus. With an optimized High Resolution T2 sequence allowing us a signal analysis and volume measurements of hippocampal layers and a diffusion tensor sequence, we could visualize this lamellar cyto-architecture of rat and human hippocampus samples with a widely spread 7T MRI scanner. Our T2 sequence allowed us to measure the thickness of the granular cell layer of the hippocampal formation and the diffusion tensor sequence allowed us to isolate the tri- synaptic circuit in rats and humans. These optimized sequences open perspectives on in vivo studies of animal models or pathological human hippocampus
van, de Looij Yohan. "Imagerie spirale du tenseur de diffusion à 7-T : application au cerveau du rat traumatisé." Université Joseph Fourier (Grenoble), 2006. http://www.theses.fr/2006GRE10288.
Повний текст джерелаThe purpose of this thesis was to implement a robust fast diffusion tensor imagines sequence on a 7-T small bore system. We implemented a Twice Refocused Spin Echo sequence in order to cancel eddy currents problems on our system. Spiral k-space acquisition was preferred to EPI for its insensitivity to motion and flow artifacts, very important in diffusion imaging. We developed software (in Matlab) to reconstruct spiral diffusion weighted and tensor images as weil as maps of tensor derived parameters: anisotropy indices, and color maps. We used a free software (MedfNRfA OTI Track) developed by P. Fillard from INRIA Nice-Sofia Antipolis in order to track white matter fibers in the rat brain. After preliminary calibrations as weil as validations on different phantoms and healthy rat brain, the implemented sequence was applied to traumatic rat brain injury. Ln this model, developed in our laboratory, the traumatism was induced by impact-acceleration method. The aim of this study was to early characterize post-traumatic cerebral edema by the mean of diffusion tensor imaging. Variations of mean diffusivity in the traumatic rat brain provided information about the type of cerebral edema induced by traumatic brain injury. Modifications of anisotropy indices in corpus callosum of traumatic rat brain provided evidence for presence of diffuse axonal injury. Fiber tracking in the corpus callosum of rat brain showed axonal rupture on the center of traumatic rat corpus callosum
Moreau, Thierry. "Etude structurale et fonctionnelle du T-kininogène de rat, thiostatine, et de ses fragments protéolytiques." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37616636p.
Повний текст джерелаCasemayou, Audrey. "Vav1 contrôle le développement des lymphocytes T régulateurs et des maladies d'origine immune." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1583/.
Повний текст джерелаAutoimmune and allergic diseases are multifactorial diseases resulting from complex interactions between genetic and environmental factors. Human genetic studies are hampered by the genetic heterogeneity of human population and the variability of environment. Our team has developed a rat model to investigate the genetic control of immune diseases. This model is based on two rat strains, BN and LEW, which are different for their immune responses. These differences are associated with opposite susceptibility to autoimmune and allergic diseases. LEW rats are susceptible, and BN rats resistant, to type-1-mediated autoimmune diseases, like experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Conversely, BN rats are susceptible, and LEW rats resistant, to type-2-mediated allergic disorders induced by heavy metal injections. Genetic studies in this model have identified at the acrocentric tip of chromosome 9 (c9), a region that controls the susceptibility to central nervous system inflammation (locus Eae4) and the susceptibility to heavy metal-triggered immune disorders (locus Iresp3). This region also controls the level of CD45RC expression on T cells. This level defines subsets of T lymphocytes (CD45RChigh and CD45RClow) that are characterized by different cytokinic profiles and functions. The colocalization of these three loci suggests that this region contains a gene or set of genes that plays a major role in the control of immune system homeostasis. During my thesis, genetic dissection of these loci using rat congenic and sub-congenic lines led to narrow down Iresp3 and Cdexp1 to a 117 kb region and Eae4 to a 1cM region that includes Iresp3 and Cdexp1. We further demonstrated that, in basal conditions, the 117 kb region controls the absolute number and proportion of regulatory Foxp3+ T cell population (Treg) (locus Fort1). The haplotypic maps of six rat strains allowed us to associate R63W polymorphism in exon 1 of Vav1 with a decreased expression of type 1 cytokines and an increased proportion and number of Treg. . In vitro studies showed that the R63W polymorphism impacts the cellular amount of Vav1 protein and its function. In fact, the Vav1-63W variant was responsible for a 4 fold reduction of Vav1 protein and for Vav1 constitutive activation, revealed by its tyrosine hyperphosphorylation and increased guanine nucleotide exchange factor activity. Moreover, Vav1-63W is increased by 4 fold as compared to Vav1-63R. Vav1-63W is also associated with a decrease of calcium flux after TCR engagement, which may be related to the decrease in the total amount of Vav1 and thus to the decrease of cellular Vav1 adaptor capacity. Finally, human studies of the orthologous gene showed the association of an haplotype in intron 1 of VAV1 with MS. This work demonstrates the power of translational researches going from animal models to human pathology and suggests that alterations in Vav1 signaling could be a new target for the management and treatment of immune diseases such as MS
Martins, Andr? Olimpio. "Cortisol e testosterona salivares como biomarcadores de estresse e recupera??o em atletas de corrida de aventura." UFVJM, 2013. http://acervo.ufvjm.edu.br/jspui/handle/1/789.
Повний текст джерелаApproved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2016-01-04T12:31:00Z (GMT) No. of bitstreams: 2 andre_olimpio_martins.pdf: 2403767 bytes, checksum: 4b49a301c8017ae8a0db22438d3dbb77 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)
Made available in DSpace on 2016-01-04T12:31:00Z (GMT). No. of bitstreams: 2 andre_olimpio_martins.pdf: 2403767 bytes, checksum: 4b49a301c8017ae8a0db22438d3dbb77 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2013
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)
Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)
A Corrida de aventura ? uma competi??o praticada em contato com a natureza, na qual o competidor utiliza obst?culos naturais para a pr?tica de v?rias modalidades esportivas combinadas. O cortisol salivar (CT) pode ser utilizado como biomarcador do estresse e estados catab?licos. A concentra??o salivar de testosterona (TT) pode representar um marcador de estado anab?lico do, j? que seus efeitos fisiol?gicos est?o relacionados com o repara??o tecidual. A propor??o entre a atividade anab?lica/catab?lica pode ser dada pela an?lise da raz?o testosterona/cortisol (T/C). O objetivo deste trabalho foi quantificar as concentra??es de CT e TT de participantes de uma corrida de aventura, para determina??o do impacto fisiol?gico deste tipo de prova. O estresse e a recupera??o dos atletas foram inferidos pela an?lise da concentra??o de CT e TT e da T/C, 1 semana antes da competi??o (dia 1), 1 dia antes da competi??o (dia 2), no dia da competi??o (dia 3) e 1 dia ap?s a competi??o (dia 4). Frequ?ncia card?aca e VO2m?x foram registrados para avalia??o da intensidade de esfor?o da prova. As concentra??es de CT para o dia 2 e 3, n?o se elevaram em rela??o ?s concentra??es apresentadas no dia 1. Entretanto, no dia 4, as concentra??es de CT foram superiores em compara??o ?s concentra??es dos dias 1, 2 e 3. O ritmo TT normal foi observado nos 04 dias analisados e n?o foi observada varia??o nas concentra??es de TT. A raz?o T/C apresentou-se diminu?da no dia 4 em compara??o ao dia 1. Os resultados mostraram que a T/C apresentou-se reduzida em mais de 75% no dia 4. Conclus?es: 1. Corrida de aventura ? um evento multiesportivo de alta intensidade de esfor?o f?sico e desafia homeostase e alostase corporais; 2. O esfor?o do treinamento e da competi??o possivelmente mostrou-se desajustado ao preparo f?sico dos atletas analisados, j? que, o ritmo CT observado, tanto no per?odo pr?, quanto no p?s-competi??o, indicou estados de exaust?o e catabolismo intenso, respectivamente. Contudo, mais analises s?o necess?rias para compreender se o esfor?o da competicao foi realmente desajustado para o organismo do atleta ou se o esfor?o f?sico n?o foi intenso o suficiente para evocar uma resposta dos eixos end?crinos analisados.
Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2013.
ABSTRACT Adventure racing is a competition practiced in contact with nature where the competitor uses natural obstacles to practice various combined sports. The salivary cortisol (CT) can be used as a biomarker of stress and catabolic states. The concentration of salivary testosterone (TT) may represent a marker of anabolic status since its physiological effects are related tissue repair. The ratio of the anabolic activity/catabolic can be given by analysis of the testosterone/cortisol ratio (T/C). The aim of this study was to quantify the CT and TT concentrations of the participants of an adventure race to determine the physiological impact of such test. Stress and recovery of athletes were inferred by analyzing the TC and TT and T / C concentration of: 1 week before competition (day 1), 1 day before competition (day 2), competition day (day 3) and 1 day after competition (day 4). VO2max and heart rate were recorded to assess the intensity of effort of competition. The concentrations of CT to day 2 and 3 did not increase compared to the concentrations showed on day 1. However, on day 4, the TC concentrations were higher compared to concentrations on days 1, 2 and 3. The TT regular rhythm was observed in 04 days and there was no variation in the concentration of TT. The ratio T/C appeared reduced at day 4 compared to day 1. The results showed that T/C appeared reduced by more than 75% in 4 days. Conclusions: 1. Adventure Racing is a multisport event of high intensity physical exertion and challenges homeostasis and allostasis body; 2. The stress of training and competition possibility proved inadequate to the physical preparation of athletes analyzed, since, CT rhythm observed in both pre and post-competition showed states of exhaustion and intense catabolism, respectively. 3. However, more analyses is necessary to understand if the competition was wrong to the athletic`s organism or if the effort was not intense enough to stimulate an answer from the endocrine axis analyzed.