Дисертації з теми "Systems physiology"
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Santin, Joseph M. "Context-dependence of physiological systems: environment-physiology interactions in the respiratory control system." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright149336916471128.
Повний текст джерелаChristensen, Heather R. "Molecular and Integrated Systems Physiology of Prolactin." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1314040076.
Повний текст джерелаButler, Jamie Andrew. "Data-based mechanistic modelling of systems in plant physiology." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369469.
Повний текст джерелаHealey, Jennifer Anne. "Wearable and automotive systems for affect recognition from physiology." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/9067.
Повний текст джерелаIncludes bibliographical references (p. 152-158).
Novel systems and algorithms have been designed and built to recognize affective patterns in physiological signals. Experiments were conducted for evaluation of the new systems and algorithms in three types of settings: a highly constrained laboratory setting, a largely unconstrained ambulatory environment, and a less unconstrained automotive environment. The laboratory experiment was designed to test for the presence of unique physiological patterns in each of eight different emotions given a relatively motionless seated subject, intentionally feeling and expressing these states. This experiment generated a large dataset of physiological signals containing many day-to-day variations, and the proposed features contributed to a success rate of 81% for discriminating all eight emotions and rates of up to 100% for subsets of emotion based on similar emotion qualities. New wearable computer systems and sensors were developed and tested on subjects who walked, jogged, talked, and otherwise went about daily activities. Although in the unconstrained ambulatory setting, physical motion often overwhelmed affective signals, the systems developed in this thesis are currently useful as activity monitors, providing an image diary correlated with physiological signals. Automotive systems were used to detect physiological stress during the natural but physically driving task. This generated a large database of physiological signals covering over 36 hours of driving. Algorithms for detecting driver stress achieved a recognition rates of 96% using stress ratings based on task conditions for validation and 89% accuracy using questionnaires analysis for validation. Further results in which metrics of stress from video tape annotations of the drive were correlated with physiological features showed highly significant correlations (up to r = .77 for over 4000 samples). Together, these three experiments show a range of success in recognizing affect from physiology, showing high recognition rates in somewhat constrained conditions and highlighting the need for more automatic context sensing in unconmore automatic context sensing in unconstrained conditions. The recognition rates obtained thus far lend support to the hypothesis that many emotional differences can be automatically discriminated in patterns of physiological changes.
by Jennifer A. Healey.
Ph.D.
Rees, J. A. "Studies on adhesive gland systems in monogeneans." Thesis, University of East Anglia, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372362.
Повний текст джерелаLong, Lu. "The Anglo-tensin and endothelin systems in hypoxia-induced pulmonary hypertension." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312091.
Повний текст джерелаDu, Beau Amy. "Neurotransmitter phenotypes of descending systems in the rat lumbar spinal cord." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4721/.
Повний текст джерелаKnight, Anthony. "A systems pharmacology approach to the adenosine A1 receptor." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/75201/.
Повний текст джерелаAshrafian, Hutan. "Global bio-systems modulation and the translational metabolic physiology of bariatric surgery." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25304.
Повний текст джерелаBierbower, Sonya M. "ENVIRONMENTAL EFFECTS ON BEHAVIOR AND PHYSIOLOGY IN CRAYFISH." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/778.
Повний текст джерелаBergman, Esbjörn. "Changes in sensory systems during aging : an experimental study in the rat /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3900-4/.
Повний текст джерелаHarrigan, Paul Richard. "Factors influencing the stability of dehydrated liposomal systems." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26416.
Повний текст джерелаMedicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
Schmitt, Daniel T. "Time series analysis of real-world complex systems - climate, finance, proteins, and physiology." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60656.
Повний текст джерелаChintapalli, Venkateswara Rao. "An integrative and systems biology approach to Drosophila melanogaster transcriptomes." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3361/.
Повний текст джерелаCroft, Wayne D. "A systems and molecular analysis of G protein-mediated signalling." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/49621/.
Повний текст джерелаCaldji, Christian. "Early environmental regulation of neural systems mediating fearfulness." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103367.
Повний текст джерелаStudies with the handling paradigm have lead to the idea that variations mother-pup interactions may actually be the cause of the handling effects. As adults, the offspring of mothers which exhibited high levels of licking/grooming and arched-back nursing (LG-ABN) showed substantially reduced behavioral fearfulness in response to novelty compared to the offspring of low LG-ABN mothers. In addition, the adult offspring of the high and low LGABN mothers showed the same receptor and molecular profiles as H and NH adult offspring. Corticotropin releasing factor (CRF) and alpha2 norepinephrine receptor levels, additional receptor systems thought to be important in the expression of fearfulness, differed in these animals too. Adoption studies give further support to the maternal hypothesis in the finding that the expression mRNA for the gamma2 sub-unit of the GABAA receptor complex can be differentially expressed as a result of different offspring to mother combinations.
Taken together, these findings suggest that early life events (ie: naturally occurring differences in maternal care) during the first few days of life have long-term effects on the development of central neurotransmitter systems, which mediate the expression of fearfulness to novelty.
Riquelme, Zubiria Elia. "Analysing the role of secretion systems in the physiology and pathogenesis of Brucella." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT084.
Повний текст джерелаBrucellosis is a widespread zoonotic disease caused by bacteria of the genus Brucella. The human disease represents an important cause of morbidity worldwide whereas animal brucellosis is associated with serious economic losses caused mainly by abortion and infertility in ruminants. Brucella virulence depends on its ability to survive and replicate within host cells. This requires the Brucella VirB type IV secretion system (T4SS). The T4SS translocates effector proteins which subvert the host cell biology and defences, allowing it to create a novel intracellular niche in which it survives and multiplies.The VirB T4SS is a multi-protein complex encoded by the 12 genes of the virB operon. While there is some information on the structure of the VirB T4SS, little is known about the mechanisms that Brucella uses to deliver T4SS effectors. In this thesis we showed that the Gly295 of VirB10 in B. suis, a residue within a conserved gate motif (GxxGxxG) near the antenna projection region, contributes to the regulation of substrate transfer across the outer membrane. This was validated with the CyaA reporter system which indicates a higher translocation of Brucella effectors in the VirB10G295R. We can conclude that the G295R mutation renders the T4SS unable to regulate the secretion this suggests, a constitutively open channel conformation that leads to the unregulated release of effector proteins.The VirB T4SS is the only complex secretion system used by Brucella.Brucella does use two transport systems to export proteins from the cytoplasm; the Sec system and the Tat system. Tat is present in many, but not all, bacteria and is used to export folded proteins from the cytosol to the bacteria envelope or to the extracellular environment. There have been no reports of investigation of the Brucella Tat system. . An in-silico screen of the Brucella genome using the consensus N-terminal signal SRRxFLK revealed 27 potential substrates. To investigate the role of the Tat system in Brucella physiology ad virulence, we attempted to create a Brucella tat mutant using several strategies: none were successful. Analysis of the predicted Tat substrates showed that several could be essential physiological processes, explaining why we could not mutate the Brucella Tat system. . Moreover, Tn-Seq data from the De Bolle group identified tatC as an essential gene. Therefore, we have used an alternative in vivo reporter system to confirm the Tat dependency of the predicted substrates. We proved that a heterologous system constructed in E. coli works to identify Brucella Tat signal sequences. Altogether, we proposed that the Tat system is an essential protein transport system for viability in Brucella spp. Our results contribute to a further understanding of the mechanisms of translocation of T4SS protein effectors and give information about how the Tat pathway is contributing to the role of physiology of Brucella. Understanding the biology of the pathogen that causes brucellosis is an essential step in the development of control measures
Narayanaswamy, Variankaval. "Characterization of phase transitions in transdermal drug delivery systems." Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/8645.
Повний текст джерелаMournetas, Virginie. "Defining stemness of human embryonic stem cells : a systems biology approach." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2008879/.
Повний текст джерелаBuratti, Sara <1981>. "Pharmaceutical residues in aquatic systems: mode of action and effects on mussel physiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3539/.
Повний текст джерелаHung, You-jou. "Shoulder position sense and kinesthetically guided reaching accuracy in individuals with anterior shoulder instability." Diss., University of Iowa, 2008. https://ir.uiowa.edu/etd/204.
Повний текст джерелаBursell, James David Hingston. "Swelling-activated membrane transport systems in vertebrate and protozoan cells : a comparative study." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337564.
Повний текст джерелаWilliamson, Beth. "Determinants of transcriptional regulation of transport and oxidative processes in human model systems." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/15053/.
Повний текст джерелаKoslow, Jennifer Marie. "Mixed mating systems, pathogens, and plant community ecology." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3232578.
Повний текст джерела"Title from dissertation home page (viewed July 11, 2007)." Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4208. Advier: Keith Clay.
Lam, Minh Phuc. "Interactions of acute alcohol with the endogenous opioid and corticotropin-releasing hormone systems in the rat brain." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96687.
Повний текст джерелаL'abus d'alcool et la dépendance sont des troubles psychiatriques complexes impliquant des multiples systèmes neurobiologiques dans diverses régions du cerveau dont l'amygdale centrale (CeA). Dans le cadre du complexe amygdalien étendu, la CeA a été démontré à jouer un rôle clé dans le développement de la dépendance à l'alcool. Ainsi, l'objectif principal des études dans cette thèse était d'étudier les effets de l'administration d'alcool à court terme sur l'activité des peptides opioïdes endogènes et l'hormone corticolibérine (CRH) au niveau de la CeA, ainsi que les interactions entre ces deux systèmes neurochimiques. En utilisant la technique de microdialyse in vivo, les expériences de cette thèse ont démontré les effets de l'administration d'alcool à court terme sur la libération des peptides opioïdes (endorphines, enképhalines, et dynorphines) et CRH au niveau de la CeA. De plus, les expériences de cette thèse ont demontré les effets des microinjections dans la CeA soit CRH ou les antagonistes des récepteurs CRH de type 1 (CRHR1) et de type 2 (CRHR2) sur la libération des beta-endorphine et dynorphine dans des conditions basales et après un traitement avec l'alcool à court terme. Les résultats de ces études de microdialyse in vivo ont démontré qu'au niveau de la CeA (1) le traitement avec l'alcool à court terme a induit des augmentations des concentrations extracellulaires de beta-endorphine et dynorphine A1-8 et non pas d'enképhaline qui sont dépendantes sur la dose d'alcool et le temps après l'injection; (2) le traitement avec l'alcool à court terme a causé une augmentation des concentrations extracellulaires de CRH dépendante sur la dose d'alcool et le temps après injection; (3) la microinjection de CRH a produit une augmentation des concentrations extracellulaires de beta-endorphine; (4) le blocage de CRHR1 et CRHR2 a atténué l'augmentation des concentrations extracellulaires de β-endorphine induit par l'alcool; (5) la microinjection de CRH a induit une augmentation des concentrations extracellulaires de dynorphine A1-8 et (6) le blocage de CRHR2 a atténué l'augmentation des concentrations extracellulaires de dynorphine A1-8 induit par l'alcool. En résumé, le traitement avec l'alcool à court terme a induit une augmentation de la CRH au niveau de la CeA. Après sa libération, la CRH peut interagir avec CRHR1 et CRHR 2 pour stimuler la libération des endorphines et l'interaction avec CRHR2 peut stimuler la libération des dynorphines A1-8 au CeA. Ainsi, il peut être proposé que les interactions entre les systèmes opioidergiques et la CRH au niveau de la CeA causées par l'administration d'alcool à court terme pourraient être importantes dans la consommation d'alcool.
Miraldi, Emily R. (Emily Rae). "Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72824.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Metabolic syndrome describes a complex set of obesity-related disorders that enhance diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase lb (PTPlb) deletion mice (L-PTPlb-/-) suggests that hepatic PTPlb inhibition would mitigate metabolic syndrome progression through amelioration of hepatic insulin resistance, endoplasmic reticulum stress, and whole-body lipid metabolism. However, the network alterations underlying these phenotypes are poorly understood. Mass spectrometry was used to quantitatively discover protein phosphotyrosine network changes in L-PTP lb-/- mice relative to control mice under both normal and high-fat diet conditions. A phosphosite set enrichment analysis was developed to identify numerous pathways exhibiting PTPlb- and diet-dependent phosphotyrosine regulation. Detection of PTP lb-dependent phosphotyrosine sites on lipid metabolic proteins initiated global lipidomics characterization of corresponding liver samples and revealed altered fatty acid and triglyceride metabolism in L-PTPlb-/- mice. Multivariate modeling techniques were developed to infer molecular dependencies between phosphosites and lipid metabolic changes, resulting in quantitatively predictive phenotypic models.
by Emily R. Miraldi.
Ph.D.
Santos, Magalhães André. "Subjective and objective assessment of physically active people with knee injury." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/60066/.
Повний текст джерелаPethick, Jamie. "The effects of neuromuscular fatigue on the complexity of isometric torque output in humans." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/60067/.
Повний текст джерелаFan, Li 1967. "Interactions of renin-angiotensin and natriuretic peptide systems in control of blood pressure during ovine pregnancy." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39904.
Повний текст джерелаAugust, Elias. "Stability and dissipativity theory for nonnegative and compartmental dynamical systems." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/13068.
Повний текст джерелаMarques, Bernardo José Santos. "Veracity: low cost physiology assessment tool using virtual reality." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/22731.
Повний текст джерелаAnxiety disorders affect many individuals, conditioning their daily life routines. Specific phobia is one example of an anxiety disorder, which is an irrational fear towards an object, or situation. Phobics felt a distorted reality, and usually try to avoid the phobic element, which will only intensify the problem. The evolution of technology and the miniaturization brought to the foreground not only allow the development of portable solutions for the assessment of psychological and behavior but also new possibility to mimic the real world likes Virtual Reality (VR) outside of the laboratory setting. Recent studies, describe Virtual Reality exposure as effective, when compared to in vivo exposure, with the benefit of being less aggressive to the phobic individual. In this dissertation, we propose Veracity, an affordable and portable system, which relies on VR to present more ecological and virtual stimuli to phobic individuals while monitoring their physiological and behaviour response. We used spider phobias as the main case study of our system. While presenting the VR stimuli, using a game divided in a set of increasing difficulty levels, Veracity allows the interaction with the virtual environment through hand gesture. Simultaneously the individual’s reaction is acquired (ECG, HR, RR, VIDEO, Screenshots, 3D objects tracking, etc.) using external resources and two smartphone applications. Veracity also supports data management for post processing integrated with the cloud. The gamification approach and its ability to customize the virtual stimuli provides enough versatility to foster its usefulness in clinical practice as a solution to monitor and elicit natural reactions from individuals with specific phobias.
Distúrbios de ansiedade afetam muitos indivíduos, condicionando as suas rotinas. Um exemplo é o caso da fobia específica, um medo irracional em relação a um objeto ou situação. Indivíduos fóbicos sentem uma realidade distorcida, e geralmente, tentam evitar o elemento fóbico, o que intensifica o problema. A evolução da tecnologia não só permite o desenvolvimento de soluções portáteis para a avaliação fisiológica e comportamental, criando novas possibilidades para imitar o mundo real utilizando Realidade Virtual (VR) fora do ambiente controlado de laboratório. Estudos recentes, descrevem a exposição a VR como sendo eficaz quando comparada com a exposição in vivo, sendo menos agressiva para o individuo. Nesta dissertação, propomos o Veracity, um sistema portátil e economicamente acessível, para apresentação de estímulos virtuais a indivíduos fóbicos e interação com esse ambiente através do reconhecimento da mão e gestos enquanto a sua resposta fisiológica e comportamental é monitorizada. O principal caso de estudo do nosso sistema é a fobia de aranhas. O sistema é rápido de configurar, permite a recolha de dados fora do ambiente de laboratório e a exposição a estímulos, que permitem reações mais naturais. Simultaneamente, a reação do indivíduo é adquirida (ECG, HR, RR, VIDEO, Imagens, 3D tracking, etc.), utilizando recursos externos e duas aplicações para dispositivos móveis. Veracity suporta ainda a gestão dos dados recolhidos, para pósprocessamento integrado com a cloud. A sua aproximação baseada em jogos e a sua capacidade de personalizar os estímulos virtuais, proporciona um nível de versatilidadeque, que promove a sua utilidade na prática clínica como uma solução para provocar reações naturais e monitorizarem individuos com fobias específicas.
Hu, Keli. "Signal transduction systems involved in ischemic preconditioning and ATP-sensitive K+ channels." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0002/NQ44456.pdf.
Повний текст джерелаMohtat, Nadereh. "Study of magnetic field effects on radical reactions and of the mobility of transients in microheterogeneous systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28361.pdf.
Повний текст джерелаRoutledge, Hayden Swailes. "Regulation of myogenic tone in cerebral and mesenteric resistance arteries by metabolic agents and second messenger systems." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/4904/.
Повний текст джерелаLocke, James C. W. "A systems biology approach to the Arabidopsis circadian clock." Thesis, University of Warwick, 2006. http://wrap.warwick.ac.uk/58550/.
Повний текст джерелаChik, Tai-wai David, and 戚大衛. "Global coherent activities in inhibitory neural systems: Chik Tai Wai David." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31040408.
Повний текст джерелаJia, Wei-Guo. "Calcium-related signal transduction systems in developing visual cortex." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30927.
Повний текст джерелаMedicine, Faculty of
Graduate
Insel, Nathan. "Physiology of the medial frontal cortex during decision-making in adult and senescent rats." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/196140.
Повний текст джерелаKumar, Jothi Dinesh. "Novel stromal cell signalling systems in oesophageal cancer." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/15257/.
Повний текст джерелаOrlowski, John M. "Evaluation of input-intensive soybean management systems and the effect of lactofen application on soybean physiology." UKnowledge, 2015. http://uknowledge.uky.edu/pss_etds/66.
Повний текст джерелаHitt, Lauren R., and Lars Tomanek. "ACUTE NITRATE EXPOSURE CAUSES PROTEOMIC CHANGES CONSISTENT WITH THE REGULATION OF REACTIVE OXYGEN AND NITROGEN SPECIES." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/95.
Повний текст джерелаKrjukova, Jelena. "Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4300.
Повний текст джерелаWalworth, James, David M. Kopec, Andrew Pond, and Jeff J. Gilbert. "Turfgrass Systems for Saline Irrigation Water." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2009. http://hdl.handle.net/10150/216644.
Повний текст джерелаNorton, E. R., and H. J. Borrego. "Evaluation of Envoke by Pix Interaction in Arizona Cotton Production Systems." College of Agriculture, University of Arizona (Tucson, AZ), 2006. http://hdl.handle.net/10150/198193.
Повний текст джерелаNorton, E. R., and H. J. Borrego. "Evaluation of Plant Growth Regulator Formulations in Arizona Cotton Production Systems." College of Agriculture, University of Arizona (Tucson, AZ), 2006. http://hdl.handle.net/10150/198211.
Повний текст джерелаCordes, Henrik [Verfasser], Lars Mathias [Akademischer Betreuer] Blank, and Rodríguez Julio [Akademischer Betreuer] Sáez. "Multi-scale modeling in human systems pharmacology & physiology / Henrik Cordes ; Lars Mathias Blank, Julio Sáez Rodríguez." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1194066887/34.
Повний текст джерелаTegge, Samuel. "The Mechanism of Biotremor Production in the Veiled Chameleon (Chamaeleo calyptratus)." TopSCHOLAR®, 2018. https://digitalcommons.wku.edu/theses/2336.
Повний текст джерелаBohara, Gyanendra. "Application of Statistical Physics in Human Physiology: Heart-Brain Dynamics." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1248449/.
Повний текст джерелаNorton, E. R., and H. Borrego. "Evaluation of Commercial Harvest Aid Products in Arizona Upland Cotton Production Systems." College of Agriculture, University of Arizona (Tucson, AZ), 2006. http://hdl.handle.net/10150/198210.
Повний текст джерелаNorton, E. R., and D. L. Hatch. "2006 Evaluation of Commercial Harvest Aid Materials in Arizona Cotton Production Systems." College of Agriculture, University of Arizona (Tucson, AZ), 2007. http://hdl.handle.net/10150/198216.
Повний текст джерела