Готові списки джерел за темами / Synthesis of carbocyclic cleft molecules

Добірка наукової літератури з теми "Synthesis of carbocyclic cleft molecules"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Synthesis of carbocyclic cleft molecules"

1

Kimber, Marc C., Andrew C. Try, Leoni Painter, Margaret M. Harding, and Peter Turner. "Synthesis of Functionalized Chiral Carbocyclic Cleft Molecules Complementary to Tröger's Base Derivatives." Journal of Organic Chemistry 65, no. 10 (May 2000): 3042–46. http://dx.doi.org/10.1021/jo991741p.

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2

Lee, Connie K. Y., Jennifer L. Groneman, Peter Turner, Louis M. Rendina, and Margaret M. Harding. "Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts." Tetrahedron 62, no. 20 (May 2006): 4870–78. http://dx.doi.org/10.1016/j.tet.2006.03.014.

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3

Halder, Joydev, Debabrata Das та Samik Nanda. "A distinctive transformation based diversity oriented synthesis of small ring carbocycles and heterocycles from biocatalytically derived enantiopure α-substituted-β-hydroxyesters". Organic & Biomolecular Chemistry 16, № 14 (2018): 2549–75. http://dx.doi.org/10.1039/c8ob00233a.

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4

Jilka, Priti, Claire Millington, Mark R. J. Elsegood, Josef W. A. Frese, Simon Teat, and Marc C. Kimber. "The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis." Tetrahedron 66, no. 48 (November 2010): 9327–31. http://dx.doi.org/10.1016/j.tet.2010.10.027.

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5

Koga, Masakazu, Koichi Tamai, Mitsunori Ueda, Toshinori Uchida, Toshiyuki Yamamuro, Masahiro Shigeta, Masaharu Yamamoto, Takaaki Suzuki, and Toshiaki Saeki. "Synthesis and Properties of Carbocyclic 5′- Nor Oligodeoxynucleotides as Potential Antisense Molecules." Phosphorus, Sulfur, and Silicon and the Related Elements 177, no. 8-9 (August 2002): 2099–100. http://dx.doi.org/10.1080/10426500213320.

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6

Llona-Minguez, Sabin, and Simon P. Mackay. "Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)." Beilstein Journal of Organic Chemistry 10 (June 11, 2014): 1333–38. http://dx.doi.org/10.3762/bjoc.10.135.

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Анотація:
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.
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7

Al-Saad, Dalya, Misal Giuseppe Memeo, and Paolo Quadrelli. "#Nitrosocarbonyls 1: Antiviral Activity ofN-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/472373.

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Анотація:
Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with thein vitroantiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.
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8

Grillo, Alessandro, and Bruno Mattia Bizzarri. "Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents." Catalysts 12, no. 2 (January 25, 2022): 150. http://dx.doi.org/10.3390/catal12020150.

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Анотація:
The Diels–Alder reaction (DAR) is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings, and it is widely used in the synthesis of organic molecules and drugs. Due to the high regio- and stereo-selectivity and its versatility, DARs have represented a powerful tool for organic chemistry for many years. In addition, the asymmetric DAR has become a fundamental synthetic approach in the preparation of optically active six-membered rings and natural compounds. The COVID-19-related pandemic requires continuous research; DAR represents an useful method to obtain optically active intermediates for the synthesis of antiviral agents under different catalytic conditions. We would like to highlight an intriguing synthetic procedure applied to the development of novel synthetic protocols that are potentially useful against a large panel of viruses and other unmet diseases.
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9

Roberts, S. M., and N. M. Williamson. "The Use of Enzymes for the Preparation of Biologically Active Natural Products and Analogues in Optically Active Form." Current Organic Chemistry 1, no. 1 (May 1997): 1–20. http://dx.doi.org/10.2174/1385272801666220121181731.

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Анотація:
The enantioselective hydrolysis of chiral esters using esterases and lipases gives access to key optically active intermediates en route to prostaglandins, coriolic acid, the anti-HIV agent carbovir and mevinic acid type hypocholestemic agents. The hydrolysis of meso-esters using hydrolases is a very efficient strategy in organic synthesis and has been used to prepare the carbocyclic nucleosides neplanocin and risteromycin. Acylases have been used to prepare (-)-carbovir and both enantiomers of a GABA-mimetic from 2-azabicyclo[2.2.1)hept-5-en-3-one. The employment of nitrilases and nitrile hydratases is gaining in popularity; for example, prochiral 2-benzoyloxypropane-1,3-dinitrile is hydrolysed to (S)-3-benzoyloxy-4-cyanobutanoic acid with exquisite selectivity. Lipases in organic solvents can effect esterification, transesterification and interesterification reactions and this popular methodology has been used to prepare key norcarbocyclic nucleotides and carbocyclic oxetanocin A in single enantiomer form. Yeast­ catalysed reductions of ketones afford optically active secondary alcohols, typically employed for the synthesis of pheromones, fragrances and chemotactic agents such as leukotriene-84. Instead of a whole-cell system such as yeast, partially purified dehydrogenases can be employed to synthesise (S)-secondary alcohols, for examplan intermediate to the antifungal agent brefeldin-A. Biohydroxylations are important reactions and are being applied to a wide range of substrates. The oxidation of benzene and derivatives to the corresponding cyclohexadiene diols are classic examples and have provided a route to analogues of cyclophellitol. Similarly, mono-oxygenase catalysed Baeyer-Villiger reactions are now well-documented and have furnished intermediates to carbocyclic-AZT, lipoic acid and azadirachtin. Sulfoxides of high optical purity have been prepared by yeast-catalysed oxidation, while enzymes in the transferase and lyase classes have been used to make carbohydrates and amino acids. In conclusion, the science of biotransformations opens up numerous synthetic routes to a wide variety of target molecules that are not easily accessible by other methods of synthetic organic chemistry.
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10

Maycock, Christopher D., M. Teresa Barros, António G. Santos, and Lício S. Godinho. "An application of quinic acid to the synthesis of cyclic homochiral molecules: A common route to some interesting carbocyclic nucleoside precursors." Tetrahedron Letters 34, no. 49 (December 1993): 7985–88. http://dx.doi.org/10.1016/s0040-4039(00)61531-9.

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Дисертації з теми "Synthesis of carbocyclic cleft molecules"

1

Niemiec-Plebanek, Elzbieta. "Synthesis of small molecules targeting filovirus inhibition." Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE2063.

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Анотація:
Les virus sont au centre de problème de santé publique. En raison de l'apparition de nouveaux virus et pour certains de leur résistance aux traitements existants il est toujours d’actualité de développement de nouveaux agents antiviraux. En général, la stratégie de lutte contre les infections virales est basée sur la vaccination ou sur l'activité des petites molécules, interférant avec un ou plusieurs processus biologiques participant au cycle de vie du virus. Dans ce contexte, nous avons conçu et synthétisé des petites bibliothèques de molécules visant des propriétés anti-filovirus. Dans ce projet de recherche, nous avons mis l'accent sur le développement de composés ciblant la protéine Niemann-Pick C1, les protéases cathepsine et le processus de réplication. Lors du développement des inhibiteurs de Neimann-Pick C1 plus de 70 composés ont été synthétisés, portant le squelette pipérazine. Afin d'obtenir des inhibiteurs de cystéine cathepsines pouvant être impliqués dans la réplication du virus Ebola, nous avons synthétisé une petite bibliothèque de composés porteurs de groupement 1,3,5-triazine et possédant des activité de l’ordre du nanomolaire sur les cathepsines B, K, L et S. Enfin, pour inhiber la réplication du virus en ciblant SAH hydrolase, nous avons proposé une série de C-nucléosides carbocyclic ayant motif de 4-aza-7,9-dideazaadenosine
The viruses cause the problem of public health. Due to the appearance of new viruses and their resistance to existing treatments there is still relevant to develop new antivirals. Generally, the strategy to combat viral infections is based on vaccination or on the activity of small molecules, interfering with one or more biological processes participating in virus life cycle. In this context, we took an effort to design and synthesize the library of small molecules possessing anti-filovirus properties. In this research project, we were focused on the developing of compounds targeting Niemann-Pick C1 protein, cathepsin proteases and replication process. In our effort into the development of the inhibitors of Neimann-Pick C1 we prepared the series of about 70 compounds, having in common the piperazine moiety. Diverse 1,4-N,N - substituents of piperazine, differencing in a size and shape were studied. In order to obtain efficient cysteine cathepsins inhibitors, we synthesized the small library of compounds bearing 1,3,5-triazine moiety. Finally, to inhibit the virus replication by targeting SAH hydrolase, we proposed the series of carbocyclic C-nucleosides having motif of 4-aza-7,9-dideazaadenosine
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2

Slater, Natasha H. "The synthesis and functionalisation of chiral cleft molecules and their application as asymmetric hydrogen bond organocatalysts." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/16855.

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Книги з теми "Synthesis of carbocyclic cleft molecules"

1

Laali, K. K. Carbocyclic and Heterocyclic Cage Compounds and Their Building Blocks: Synthesis, Structure, Mechanism, and Theory (Advances in Strained and Interesting Organic Molecules). JAI Press, 1999.

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