Добірка наукової літератури з теми "Syntenin/syndecan interaction"
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Статті в журналах з теми "Syntenin/syndecan interaction"
Zimmermann, Pascale, Zhe Zhang, Gisèle Degeest, Eva Mortier, Iris Leenaerts, Christien Coomans, Joachim Schulz, Francisca N’Kuli, Pierre J. Courtoy, and Guido David. "Syndecan Recyling Is Controlled by Syntenin-PIP2 Interaction and Arf6." Developmental Cell 9, no. 3 (September 2005): 377–88. http://dx.doi.org/10.1016/j.devcel.2005.07.011.
Повний текст джерелаZimmermann, Pascale, Zhe Zhang, Gisèle Degeest, Eva Mortier, Iris Leenaerts, Christien Coomans, Joachim Schulz, Francisca N’Kuli, Pierre J. Courtoy, and Guido David. "Syndecan Recycling Is Controlled by Syntenin-PIP2 Interaction and Arf6." Developmental Cell 9, no. 5 (November 2005): 721. http://dx.doi.org/10.1016/j.devcel.2005.10.011.
Повний текст джерелаBASS, Mark D., and Martin J. HUMPHRIES. "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling." Biochemical Journal 368, no. 1 (November 15, 2002): 1–15. http://dx.doi.org/10.1042/bj20021228.
Повний текст джерелаLee, Hawon, Yeonhee Kim, Youngsil Choi, Sojoong Choi, Eunkyung Hong, and Eok-Soo Oh. "Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1." Biochemical and Biophysical Research Communications 409, no. 1 (May 2011): 148–53. http://dx.doi.org/10.1016/j.bbrc.2011.04.135.
Повний текст джерелаImjeti, Naga Sailaja, Kerstin Menck, Antonio Luis Egea-Jimenez, Celine Lecointre, Frederique Lembo, Habib Bouguenina, Ali Badache, et al. "Syntenin mediates SRC function in exosomal cell-to-cell communication." Proceedings of the National Academy of Sciences 114, no. 47 (November 6, 2017): 12495–500. http://dx.doi.org/10.1073/pnas.1713433114.
Повний текст джерелаPradhan, Anjan K., Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo, et al. "Abstract 3394: Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3394. http://dx.doi.org/10.1158/1538-7445.am2023-3394.
Повний текст джерелаZhao, Tian, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen, and Shi‐Zhong Luo. "Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes." Cell Proliferation, April 11, 2024. http://dx.doi.org/10.1111/cpr.13645.
Повний текст джерелаPradhan, Anjan K., Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo, et al. "Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis." Molecular Cancer Therapeutics, September 18, 2023, OF1—OF13. http://dx.doi.org/10.1158/1535-7163.mct-22-0653.
Повний текст джерелаHoffer, Laurent, Manon Garcia, Raphael Leblanc, Mikael Feracci, Stéphane Betzi, Khaoula Ben Yaala, Avais M. Daulat, et al. "Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach." Journal of Medicinal Chemistry, March 20, 2023. http://dx.doi.org/10.1021/acs.jmedchem.2c01569.
Повний текст джерелаLiu, Jing, Weiwei Bai, Tianxing Zhou, Yongjie Xie, Bo Yang, Jingyan Sun, Yifei Wang та ін. "SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation". Gut, 24 лютого 2023, gutjnl—2022–327492. http://dx.doi.org/10.1136/gutjnl-2022-327492.
Повний текст джерелаДисертації з теми "Syntenin/syndecan interaction"
Garcia, Manon. "Développement de nouveaux agents anticancéreux inhibiteurs de la syntenin." Electronic Thesis or Diss., Aix-Marseille, 2021. http://theses.univ-amu.fr.lama.univ-amu.fr/210312_GARCIA_59el396udxeux306vl471dzd_TH.pdf.
Повний текст джерелаThe thesis describes the identification and optimization of selective inhibitors targeting the syntenin/syndecan complex, using a “Fragment-based drug design” (FBDD) strategy, which could pave the way for new anticancer therapies. The syntenin/syndecan interaction plays a major role in the recycling of endosomes to the plasma membrane, as well as in the biogenesis and release of exosomes derived from tumor cells. Therefore, we performed an FBDD program targeting selectively the syntenin/syndecan interaction. To do this, two different fragment library screenings were performed, one experimental the other virtual, and two fragments hits were identified that specifically inhibit the interaction of the syntenin/syndecan complex. The resolution of 3D crystallographic structures of the complexes between these two fragments and syntenin allowed their optimization by a structure-based drug design approach based on information about their binding site and the mode. SAR studies and fragment growing optimization steps, based on molecular docking studies, were carried out. My work consisted in synthesizing chemical libraries of targeted analogues resulting from molecular docking and demonstrating strong interactions with syntenin. Among all the synthesized analogues, we identified the most promising inhibitors which exhibit sub-micromolar IC50 and which affect the release pathway of exosomes derived from tumor cells, dependent on syntenin/syndecan activity