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Статті в журналах з теми "Suspended Microchannel Resonator"

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Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Vakilzadeh, Mohsen, Ramin Vatankhah, and Mohammad Eghtesad. "Tracking control of suspended microchannel resonators based on Krylov model order reduction method." Journal of Vibration and Control 25, no. 5 (November 7, 2018): 1019–30. http://dx.doi.org/10.1177/1077546318809609.

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In this paper, trajectory tracking control of suspended microchannel resonators (SMRs) is studied. A finite element procedure based on modified strain gradient theory will be used to model the SMR. Finite element methods usually lead to a model with a relatively high number of degrees of freedom. Thus, first, we will utilize the second order Krylov subspace method based on multi-moment matching to obtain a second order bilinear reduced system. Then, an output feedback controller and an optimal controller which take much less computation time and effort will be designed for the reduced system. The SMR is a micro-resonator which oscillates in a special frequency in practical cases, and thus tracking the desired paths is considered here as the control objective. Simulation results show the excellent performance of the proposed controllers.

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2

Martín-Pérez, Alberto, Daniel Ramos, Javier Tamayo, and Montserrat Calleja. "Nanomechanical Molecular Mass Sensing Using Suspended Microchannel Resonators." Sensors 21, no. 10 (May 11, 2021): 3337. http://dx.doi.org/10.3390/s21103337.

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In this work we study the different phenomena taking place when a hydrostatic pressure is applied in the inner fluid of a suspended microchannel resonator. Additionally to pressure-induced stiffness terms, we have theoretically predicted and experimentally demonstrated that the pressure also induces mass effects which depend on both the applied pressure and the fluid properties. We have used these phenomena to characterize the frequency response of the device as a function of the fluid compressibility and molecular masses of different fluids ranging from liquids to gases. The proposed device in this work can measure the mass density of an unknown liquid sample with a resolution of 0.7 µg/mL and perform gas mixtures characterization by measuring its average molecular mass with a resolution of 0.01 atomic mass units.

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3

Zakeri, Manizhe, and Seyed Mahmoud Seyedi Sahebari. "Modeling and simulation of a suspended microchannel resonator nano-sensor." Microsystem Technologies 24, no. 2 (July 25, 2017): 1153–66. http://dx.doi.org/10.1007/s00542-017-3478-6.

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4

Yan, Han, Wen-Ming Zhang, Hui-Ming Jiang, and Kai-Ming Hu. "Pull-In Effect of Suspended Microchannel Resonator Sensor Subjected to Electrostatic Actuation." Sensors 17, no. 12 (January 8, 2017): 114. http://dx.doi.org/10.3390/s17010114.

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5

Folzer, Emilien, Tarik A. Khan, Roland Schmidt, Christof Finkler, Jörg Huwyler, Hanns-Christian Mahler, and Atanas V. Koulov. "Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator." Journal of Pharmaceutical Sciences 104, no. 12 (December 2015): 4034–40. http://dx.doi.org/10.1002/jps.24635.

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6

Martín-Pérez, Ramos, Tamayo, and Calleja. "Coherent Optical Transduction of Suspended Microcapillary Resonators for Multi-Parameter Sensing Applications." Sensors 19, no. 23 (November 20, 2019): 5069. http://dx.doi.org/10.3390/s19235069.

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Characterization of micro and nanoparticle mass has become increasingly relevant in a wide range of fields, from materials science to drug development. The real-time analysis of complex mixtures in liquids demands very high mass sensitivity and high throughput. One of the most promising approaches for real-time measurements in liquid, with an excellent mass sensitivity, is the use of suspended microchannel resonators, where a carrier liquid containing the analytes flows through a nanomechanical resonator while tracking its resonance frequency shift. To this end, an extremely sensitive mechanical displacement technique is necessary. Here, we have developed an optomechanical transduction technique to enhance the mechanical displacement sensitivity of optically transparent hollow nanomechanical resonators. The capillaries have been fabricated by using a thermal stretching technique, which allows to accurately control the final dimensions of the device. We have experimentally demonstrated the light coupling into the fused silica capillary walls and how the evanescent light coming out from the silica interferes with the surrounding electromagnetic field distribution, a standing wave sustained by the incident laser and the reflected power from the substrate, modulating the reflectivity. The enhancement of the displacement sensitivity due to this interferometric modulation (two orders of magnitude better than compared with previous accomplishments) has been theoretically predicted and experimentally demonstrated.

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7

Son, Sungmin, Joon Ho Kang, Seungeun Oh, Marc W. Kirschner, T. J. Mitchison, and Scott Manalis. "Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis." Journal of Cell Biology 211, no. 4 (November 23, 2015): 757–63. http://dx.doi.org/10.1083/jcb.201505058.

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Osmotic regulation of intracellular water during mitosis is poorly understood because methods for monitoring relevant cellular physical properties with sufficient precision have been limited. Here we use a suspended microchannel resonator to monitor the volume and density of single cells in suspension with a precision of 1% and 0.03%, respectively. We find that for transformed murine lymphocytic leukemia and mouse pro–B cell lymphoid cell lines, mitotic cells reversibly increase their volume by more than 10% and decrease their density by 0.4% over a 20-min period. This response is correlated with the mitotic cell cycle but is not coupled to nuclear osmolytes released by nuclear envelope breakdown, chromatin condensation, or cytokinesis and does not result from endocytosis of the surrounding fluid. Inhibiting Na-H exchange eliminates the response. Although mitotic rounding of adherent cells is necessary for proper cell division, our observations that suspended cells undergo reversible swelling during mitosis suggest that regulation of intracellular water may be a more general component of mitosis than previously appreciated.

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8

Godin, Michel, Andrea K. Bryan, Thomas P. Burg, Ken Babcock, and Scott R. Manalis. "Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator." Applied Physics Letters 91, no. 12 (September 17, 2007): 123121. http://dx.doi.org/10.1063/1.2789694.

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9

Khan, M. F., S. Schmid, P. E. Larsen, Z. J. Davis, W. Yan, E. H. Stenby, and A. Boisen. "Online measurement of mass density and viscosity of pL fluid samples with suspended microchannel resonator." Sensors and Actuators B: Chemical 185 (August 2013): 456–61. http://dx.doi.org/10.1016/j.snb.2013.04.095.

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10

Stockslager, Max A., Selim Olcum, Scott M. Knudsen, Robert J. Kimmerling, Nathan Cermak, Kristofor R. Payer, Vincent Agache, and Scott R. Manalis. "Rapid and high-precision sizing of single particles using parallel suspended microchannel resonator arrays and deconvolution." Review of Scientific Instruments 90, no. 8 (August 2019): 085004. http://dx.doi.org/10.1063/1.5100861.

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11

Dextras, Philip, Thomas P. Burg, and Scott R. Manalis. "Integrated Measurement of the Mass and Surface Charge of Discrete Microparticles Using a Suspended Microchannel Resonator." Analytical Chemistry 81, no. 11 (June 2009): 4517–23. http://dx.doi.org/10.1021/ac9005149.

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12

Accoto, Celso, Antonio Qualtieri, Ferruccio Pisanello, Carlo Ricciardi, Candido Fabrizio Pirri, Massimo De Vittorio, and Francesco Rizzi. "Two-Photon Polymerization Lithography and Laser Doppler Vibrometry of a SU-8-Based Suspended Microchannel Resonator." Journal of Microelectromechanical Systems 24, no. 4 (August 2015): 1038–42. http://dx.doi.org/10.1109/jmems.2014.2376986.

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13

Reza Nejadnik, M., and Wim Jiskoot. "Measurement of the Average Mass of Proteins Adsorbed to a Nanoparticle by Using a Suspended Microchannel Resonator." Journal of Pharmaceutical Sciences 104, no. 2 (February 2015): 698–704. http://dx.doi.org/10.1002/jps.24206.

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14

Patel, Ankit R., Doris Lau, and Jun Liu. "Quantification and Characterization of Micrometer and Submicrometer Subvisible Particles in Protein Therapeutics by Use of a Suspended Microchannel Resonator." Analytical Chemistry 84, no. 15 (July 13, 2012): 6833–40. http://dx.doi.org/10.1021/ac300976g.

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15

MOTTAGHI, Mehrdad, and Habib B. GHAVIFEKR. "P-BIO-05 OPTIMIZATION OF SUSPENDED MICROCHANNEL RESONATOR WITH INTEGRATED PIEZORESISTIVE READOUT AS A HIGH-Q FACTOR BIOMOLECULAR RECOGNITION SYSTEM IN AQUEOUS ENVIROMENT(Bio-medical Equipments,Technical Program of Poster Session)." Proceedings of JSME-IIP/ASME-ISPS Joint Conference on Micromechatronics for Information and Precision Equipment : IIP/ISPS joint MIPE 2009 (2009): 397–98. http://dx.doi.org/10.1299/jsmemipe.2009.397.

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16

Lewis, Christina L., Caelli C. Craig, and Andre G. Senecal. "Mass and Density Measurements of Live and Dead Gram-Negative and Gram-Positive Bacterial Populations." Applied and Environmental Microbiology 80, no. 12 (April 4, 2014): 3622–31. http://dx.doi.org/10.1128/aem.00117-14.

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ABSTRACTMonitoring cell growth and measuring physical features of food-borne pathogenic bacteria are important for better understanding the conditions under which these organisms survive and proliferate. To address this challenge, buoyant masses of live and deadEscherichia coliO157:H7 andListeria innocuawere measured using Archimedes, a commercially available suspended microchannel resonator (SMR). Cell growth was monitored with Archimedes by observing increased cell concentration and buoyant mass values of live growing bacteria. These growth data were compared to optical density measurements obtained with a Bioscreen system. We observed buoyant mass measurements with Archimedes at cell concentrations between 105and 108cells/ml, while growth was not observed with optical density measurements until the concentration was 107cells/ml. Buoyant mass measurements of live and dead cells with and without exposure to hydrogen peroxide stress were also compared; live cells generally had a larger buoyant mass than dead cells. Additionally, buoyant mass measurements were used to determine cell density and total mass for both live and dead cells. DeadE. colicells were found to have a larger density and smaller total mass than liveE. colicells. In contrast, density was the same for both live and deadL. innocuacells, while the total mass was greater for live than for dead cells. These results contribute to the ongoing challenge to further develop existing technologies used to observe cell populations at low concentrations and to measure unique physical features of cells that may be useful for developing future diagnostics.

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17

Knudsen, Scott M., Nathan Cermak, Francisco Feijó Delgado, Barbara Setlow, Peter Setlow, and Scott R. Manalis. "Water and Small-Molecule Permeation of Dormant Bacillus subtilis Spores." Journal of Bacteriology 198, no. 1 (October 19, 2015): 168–77. http://dx.doi.org/10.1128/jb.00435-15.

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ABSTRACTWe use a suspended microchannel resonator to characterize the water and small-molecule permeability ofBacillus subtilisspores based on spores' buoyant mass in different solutions. Consistent with previous results, we found that the spore coat is not a significant barrier to small molecules, and the extent to which small molecules may enter the spore is size dependent. We have developed a method to directly observe the exchange kinetics of intraspore water with deuterium oxide, and we applied this method to wild-type spores and a panel of congenic mutants with deficiencies in the assembly or structure of the coat. Compared to wild-type spores, which exchange in approximately 1 s, several coat mutant spores were found to have relatively high water permeability with exchange times below the ∼200-ms temporal resolution of our assay. In addition, we found that the water permeability of the spore correlates with the ability of spores to germinate with dodecylamine and with the ability of TbCl3to inhibit germination withl-valine. These results suggest that the structure of the coat may be necessary for maintaining low water permeability.IMPORTANCESpores ofBacillusspecies cause food spoilage and disease and are extremely resistant to standard decontamination methods. This hardiness is partly due to spores' extremely low permeability to chemicals, including water. We present a method to directly monitor the uptake of molecules intoB. subtilisspores by weighing spores in fluid. The results demonstrate the exchange of core water with subsecond resolution and show a correlation between water permeability and the rate at which small molecules can initiate or inhibit germination in coat-damaged spores. The ability to directly measure the uptake of molecules in the context of spores with known structural or genetic deficiencies is expected to provide insight into the determinants of spores' extreme resistance.

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18

Lee, J., R. Chunara, W. Shen, K. Payer, K. Babcock, T. P. Burg, and S. R. Manalis. "Suspended microchannel resonators with piezoresistive sensors." Lab Chip 11, no. 4 (2011): 645–51. http://dx.doi.org/10.1039/c0lc00447b.

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19

Burg, T. P., and S. R. Manalis. "Suspended microchannel resonators for biomolecular detection." Applied Physics Letters 83, no. 13 (September 29, 2003): 2698–700. http://dx.doi.org/10.1063/1.1611625.

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20

Son, Sungmin, William H. Grover, Thomas P. Burg, and Scott R. Manalis. "Suspended Microchannel Resonators for Ultralow Volume Universal Detection." Analytical Chemistry 80, no. 12 (June 2008): 4757–60. http://dx.doi.org/10.1021/ac800307a.

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21

Lee, I., K. Park, and J. Lee. "Note: Precision viscosity measurement using suspended microchannel resonators." Review of Scientific Instruments 83, no. 11 (November 2012): 116106. http://dx.doi.org/10.1063/1.4768245.

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22

De Pastina, A., D. Maillard, and L. G. Villanueva. "Fabrication of suspended microchannel resonators with integrated piezoelectric transduction." Microelectronic Engineering 192 (May 2018): 83–87. http://dx.doi.org/10.1016/j.mee.2018.02.011.

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23

Wang, Yu, Mario Matteo Modena, Mitja Platen, Iwan Alexander Taco Schaap, and Thomas Peter Burg. "Label-Free Measurement of Amyloid Elongation by Suspended Microchannel Resonators." Analytical Chemistry 87, no. 3 (January 14, 2015): 1821–28. http://dx.doi.org/10.1021/ac503845f.

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24

Calmo, Roberta, Andrea Lovera, Stefano Stassi, Alessandro Chiadò, Davide Scaiola, Francesca Bosco, and Carlo Ricciardi. "Monolithic glass suspended microchannel resonators for enhanced mass sensing of liquids." Sensors and Actuators B: Chemical 283 (March 2019): 298–303. http://dx.doi.org/10.1016/j.snb.2018.12.019.

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25

von Muhlen, Marcio G., Norman D. Brault, Scott M. Knudsen, Shaoyi Jiang, and Scott R. Manalis. "Label-Free Biomarker Sensing in Undiluted Serum with Suspended Microchannel Resonators." Analytical Chemistry 82, no. 5 (March 2010): 1905–10. http://dx.doi.org/10.1021/ac9027356.

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26

Huang, Kuan-Rong, Jeng-Shian Chang, Sheng D. Chao, and Kuang-Chong Wu. "Beam model and three dimensional numerical simulations on suspended microchannel resonators." AIP Advances 2, no. 4 (December 2012): 042176. http://dx.doi.org/10.1063/1.4770321.

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27

Yan, Han, Wen-Ming Zhang, Hui-Ming Jiang, Kai-Ming Hu, Fang-Jun Hong, Zhi-Ke Peng, and Guang Meng. "A measurement criterion for accurate mass detection using vibrating suspended microchannel resonators." Journal of Sound and Vibration 403 (September 2017): 1–20. http://dx.doi.org/10.1016/j.jsv.2017.05.030.

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28

Bryan, Andrea K., Vivian C. Hecht, Wenjiang Shen, Kristofor Payer, William H. Grover, and Scott R. Manalis. "Measuring single cell mass, volume, and density with dual suspended microchannel resonators." Lab Chip 14, no. 3 (2014): 569–76. http://dx.doi.org/10.1039/c3lc51022k.

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29

Toda, Masaya, Tomoyuki Otake, Hidetoshi Miyashita, Yusuke Kawai, and Takahito Ono. "Suspended bimaterial microchannel resonators for thermal sensing of local heat generation in liquid." Microsystem Technologies 19, no. 7 (November 25, 2012): 1049–54. http://dx.doi.org/10.1007/s00542-012-1698-3.

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30

Arlett, J. L., and M. L. Roukes. "Ultimate and practical limits of fluid-based mass detection with suspended microchannel resonators." Journal of Applied Physics 108, no. 8 (October 15, 2010): 084701. http://dx.doi.org/10.1063/1.3475151.

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31

Yun, Minhyuk, Il Lee, Sangmin Jeon, and Jungchul Lee. "Facile Phase Transition Measurements for Nanogram Level Liquid Samples Using Suspended Microchannel Resonators." IEEE Sensors Journal 14, no. 3 (March 2014): 781–85. http://dx.doi.org/10.1109/jsen.2013.2287887.

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32

Modena, Mario M., Yu Wang, Dietmar Riedel, and Thomas P. Burg. "Resolution enhancement of suspended microchannel resonators for weighing of biomolecular complexes in solution." Lab Chip 14, no. 2 (2014): 342–50. http://dx.doi.org/10.1039/c3lc51058a.

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33

Vakilzadeh, Mohsen, Ramin Vatankhah, and Mohammad Eghtesad. "Dynamics and vibration analysis of suspended microchannel resonators based on strain gradient theory." Microsystem Technologies 24, no. 4 (October 25, 2017): 1995–2005. http://dx.doi.org/10.1007/s00542-017-3596-1.

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34

Hu, Ke, Pan Wu, Lin Wang, Hu-Liang Dai, and Qin Qian. "Vibration analysis of suspended microchannel resonators characterized as cantilevered micropipes conveying fluid and nanoparticle." Microsystem Technologies 25, no. 1 (May 15, 2018): 197–210. http://dx.doi.org/10.1007/s00542-018-3949-4.

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35

Lee, Il, Keunhan Park, and Jungchul Lee. "Precision density and volume contraction measurements of ethanol–water binary mixtures using suspended microchannel resonators." Sensors and Actuators A: Physical 194 (May 2013): 62–66. http://dx.doi.org/10.1016/j.sna.2013.01.046.

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36

Zhang, Wen-Ming, Han Yan, Hui-Ming Jiang, Kai-Ming Hu, Zhi-Ke Peng, and Guang Meng. "Dynamics of suspended microchannel resonators conveying opposite internal fluid flow: Stability, frequency shift and energy dissipation." Journal of Sound and Vibration 368 (April 2016): 103–20. http://dx.doi.org/10.1016/j.jsv.2016.01.029.

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37

Mu, Luye, Joon Ho Kang, Selim Olcum, Kristofor R. Payer, Nicholas L. Calistri, Robert J. Kimmerling, Scott R. Manalis, and Teemu P. Miettinen. "Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth." Proceedings of the National Academy of Sciences 117, no. 27 (June 24, 2020): 15659–65. http://dx.doi.org/10.1073/pnas.1922197117.

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Cell size is believed to influence cell growth and metabolism. Consistently, several studies have revealed that large cells have lower mass accumulation rates per unit mass (i.e., growth efficiency) than intermediate-sized cells in the same population. Size-dependent growth is commonly attributed to transport limitations, such as increased diffusion timescales and decreased surface-to-volume ratio. However, separating cell size- and cell cycle-dependent growth is challenging. To address this, we monitored growth efficiency of pseudodiploid mouse lymphocytic leukemia cells during normal proliferation and polyploidization. This was enabled by the development of large-channel suspended microchannel resonators that allow us to monitor buoyant mass of single cells ranging from 40 pg (small pseudodiploid cell) to over 4,000 pg, with a resolution ranging from ∼1% to ∼0.05%. We find that cell growth efficiency increases, plateaus, and then decreases as cell cycle proceeds. This growth behavior repeats with every endomitotic cycle as cells grow into polyploidy. Overall, growth efficiency changes 33% throughout the cell cycle. In contrast, increasing cell mass by over 100-fold during polyploidization did not change growth efficiency, indicating exponential growth. Consistently, growth efficiency remained constant when cell cycle was arrested in G2. Thus, cell cycle is a primary determinant of growth efficiency. As growth remains exponential over large size scales, our work finds no evidence for transport limitations that would decrease growth efficiency.

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38

Gross-Rother, Julia, Michaela Blech, Eduard Preis, Udo Bakowsky, and Patrick Garidel. "Particle Detection and Characterization for Biopharmaceutical Applications: Current Principles of Established and Alternative Techniques." Pharmaceutics 12, no. 11 (November 19, 2020): 1112. http://dx.doi.org/10.3390/pharmaceutics12111112.

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Detection and characterization of particles in the visible and subvisible size range is critical in many fields of industrial research. Commercial particle analysis systems have proliferated over the last decade. Despite that growth, most systems continue to be based on well-established principles, and only a handful of new approaches have emerged. Identifying the right particle-analysis approach remains a challenge in research and development. The choice depends on each individual application, the sample, and the information the operator needs to obtain. In biopharmaceutical applications, particle analysis decisions must take product safety, product quality, and regulatory requirements into account. Biopharmaceutical process samples and formulations are dynamic, polydisperse, and very susceptible to chemical and physical degradation: improperly handled product can degrade, becoming inactive or in specific cases immunogenic. This article reviews current methods for detecting, analyzing, and characterizing particles in the biopharmaceutical context. The first part of our article represents an overview about current particle detection and characterization principles, which are in part the base of the emerging techniques. It is very important to understand the measuring principle, in order to be adequately able to judge the outcome of the used assay. Typical principles used in all application fields, including particle–light interactions, the Coulter principle, suspended microchannel resonators, sedimentation processes, and further separation principles, are summarized to illustrate their potentials and limitations considering the investigated samples. In the second part, we describe potential technical approaches for biopharmaceutical particle analysis as some promising techniques, such as nanoparticle tracking analysis (NTA), micro flow imaging (MFI), tunable resistive pulse sensing (TRPS), flow cytometry, and the space- and time-resolved extinction profile (STEP®) technology.

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39

Yan, Han, Wen-Ming Zhang, Hui-Ming Jiang, Kai-Ming Hu, Zhi-Ke Peng, and Guang Meng. "Relative Vibration of Suspended Particles With Respect to Microchannel Resonators and Its Effect on the Mass Measurement." Journal of Vibration and Acoustics 141, no. 4 (March 25, 2019). http://dx.doi.org/10.1115/1.4042937.

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In this work, the three-dimensional fluid–solid interaction vibration of particle in the oscillating resonator and its effect on the dynamic characteristics are analyzed and discussed. It demonstrates that the displacement of a particle is composed of two components, one is in phase with the acceleration of resonator and the other is out of phase. The former is responsible for the added mass effect and the latter results in a small damping. A modified measurement principle for detecting the buoyant mass is then presented by considering the in-phase component. The three-dimensional (3D) fluid–solid interaction problem involving the particle, fluid, and resonator is numerically solved, and the effects of density ratio, inverse Stokes number, and the ratio of channel height to particle diameter are studied. Based on the numerical results, a function characterizing the in-phase component is identified through a fitting procedure. According to the modified measurement principle and the analytical expression for the in-phase component, a calibration method is developed for measuring buoyant mass. Using this calibration method, the systematic measurement error induced by the vibration of particles can be effectively reduced.

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40

Daryani, Mehdi Mollaie, Tomás Manzaneque, Jia Wei, and Murali Krishna Ghatkesar. "Measuring nanoparticles in liquid with attogram resolution using a microfabricated glass suspended microchannel resonator." Microsystems & Nanoengineering 8, no. 1 (August 30, 2022). http://dx.doi.org/10.1038/s41378-022-00425-8.

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AbstractThe use of nanoparticles has been growing in various industrial fields, and concerns about their effects on health and the environment have been increasing. Hence, characterization techniques for nanoparticles are essential. Here, we present a silicon dioxide microfabricated suspended microchannel resonator (SMR) to measure the mass and concentration of nanoparticles in a liquid as they flow. We measured the mass detection limits of the device using laser Doppler vibrometry. This limit reached a minimum of 377 ag that correspond to a 34 nm diameter gold nanoparticle or a 243 nm diameter polystyrene particle, when sampled every 30 ms. We compared the fundamental limits of the measured data with an ideal noiseless measurement of the SMR. Finally, we measured the buoyant mass of gold nanoparticles in real-time as they flowed through the SMR.

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41

Miettinen, Teemu P., Joon Ho Kang, Lucy F. Yang, and Scott R. Manalis. "Mammalian cell growth dynamics in mitosis." eLife 8 (May 7, 2019). http://dx.doi.org/10.7554/elife.44700.

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The extent and dynamics of animal cell biomass accumulation during mitosis are unknown, primarily because growth has not been quantified with sufficient precision and temporal resolution. Using the suspended microchannel resonator and protein synthesis assays, we quantify mass accumulation and translation rates between mitotic stages on a single-cell level. For various animal cell types, growth rates in prophase are commensurate with or higher than interphase growth rates. Growth is only stopped as cells approach metaphase-to-anaphase transition and growth resumes in late cytokinesis. Mitotic arrests stop growth independently of arresting mechanism. For mouse lymphoblast cells, growth in prophase is promoted by CDK1 through increased phosphorylation of 4E-BP1 and cap-dependent protein synthesis. Inhibition of CDK1-driven mitotic translation reduces daughter cell growth. Overall, our measurements counter the traditional dogma that growth during mitosis is negligible and provide insight into antimitotic cancer chemotherapies.

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42

Ko, Juhee, Jaewoo Jeong, Sukbom Son, and Jungchul Lee. "Cellular and biomolecular detection based on suspended microchannel resonators." Biomedical Engineering Letters, September 12, 2021. http://dx.doi.org/10.1007/s13534-021-00207-7.

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43

"Unravelling the secrets of the cell with suspended microchannel resonators." Research Outreach, no. 110 (November 7, 2019): 42–45. http://dx.doi.org/10.32907/ro-110-4245.

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44

Maillard, Damien, Annalisa De Pastina, Amir Musa Abazari, and Luis Guillermo Villanueva. "Avoiding transduction-induced heating in suspended microchannel resonators using piezoelectricity." Microsystems & Nanoengineering 7, no. 1 (April 29, 2021). http://dx.doi.org/10.1038/s41378-021-00254-1.

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AbstractCalorimetry of single biological entities remains elusive. Suspended microchannel resonators (SMRs) offer excellent performance for real-time detection of various analytes and could hold the key to unlocking pico-calorimetry experiments. However, the typical readout techniques for SMRs are optical-based, and significant heat is dissipated in the sensor, altering the measurement and worsening the frequency noise. In this manuscript, we demonstrate for the first time full on-chip piezoelectric transduction of SMRs on which we focus a laser Doppler vibrometer to analyze its effect. We demonstrate that suddenly applying the laser to a water-filled SMR causes a resonance frequency shift, which we attribute to a local increase in temperature. When the procedure is repeated at increasing flow rates, the resonance frequency shift diminishes, indicating that convection plays an important role in cooling down the device and dissipating the heat induced by the laser. We also show that the frequency stability of the device is degraded by the laser source. In comparison to an optical readout scheme, a low-dissipative transduction method such as piezoelectricity shows greater potential to capture the thermal properties of single entities.

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45

Ko, Juhee, Jaewoo Jeong, Sukbom Son, and Jungchul Lee. "Correction to: Cellular and biomolecular detection based on suspended microchannel resonators." Biomedical Engineering Letters, April 5, 2022. http://dx.doi.org/10.1007/s13534-022-00222-2.

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46

Vakilzadeh, Mohsen, Ramin Vatankhah, and Mohammad Eghtesad. "Investigation of dynamic pull-in instability of suspended microchannel resonators using homotopy analysis method." Journal of the Brazilian Society of Mechanical Sciences and Engineering 43, no. 6 (May 23, 2021). http://dx.doi.org/10.1007/s40430-021-03028-y.

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