Готові списки джерел за темами / Surfactant-Protein System

Добірка наукової літератури з теми "Surfactant-Protein System"

Автор: Grafiati

Опубліковано: 7 вересня 2023

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Статті в журналах з теми "Surfactant-Protein System"

Mason, Robert J., Kelly Greene, and Dennis R. Voelker. "Surfactant protein A and surfactant protein D in health and disease." American Journal of Physiology-Lung Cellular and Molecular Physiology 275, no. 1 (July 1, 1998): L1—L13. http://dx.doi.org/10.1152/ajplung.1998.275.1.l1.

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Surfactant protein (SP) A and SP-D are collagenous glycoproteins with multiple functions in the lung. Both of these proteins are calcium-dependent lectins and are structurally similar to mannose-binding protein and bovine conglutinin. Both form polyvalent multimeric structures for interactions with pathogens, cells, or other molecules. SP-A is an integral part of the surfactant system, binds phospholipids avidly, and is found in lamellar bodies and tubular myelin. Initially, most research interest focused on its role in surfactant homeostasis. Recently, more attention has been placed on the role of SP-A as a host defense molecule and its interactions with pathogens and phagocytic cells. SP-D is much less involved with the surfactant system. SP-D appears to be primarily a host defense molecule that binds surfactant phospholipids poorly and is not found in lamellar inclusion bodies or tubular myelin. Both SP-A and SP-D bind a wide spectrum of pathogens including viruses, bacteria, fungi, and pneumocystis. In addition, both molecules have been measured in the systemic circulation by immunologic methods and may be useful biomarkers of disease. The current challenges are characterization of the three-dimensional crystal structure of SP-A and SP-D, molecular cloning of their receptors, and determination of their precise physiological functions in vivo.

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TADENUMA, Hirohiko, Ken YAMADA, and Takamitsu TAMURA. "Analysis of Protein-Mixed Surfactant System Interactions ;." Journal of Japan Oil Chemists' Society 48, no. 3 (1999): 207–13. http://dx.doi.org/10.5650/jos1996.48.207.

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Cañadas, Olga, Bárbara Olmeda, Alejandro Alonso, and Jesús Pérez-Gil. "Lipid–Protein and Protein–Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis." International Journal of Molecular Sciences 21, no. 10 (May 25, 2020): 3708. http://dx.doi.org/10.3390/ijms21103708.

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Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid–protein and protein–protein interactions contribute to the proper maintenance of an operative respiratory surface.

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Tan, Ya-Xin, Shu-Jun Li, Hai-Tao Li, Xiao-Juan Yin, Bo Cheng, Jing-Li Guo, Na Li, Cheng-Zhong Zheng, and Hong-Yu Chang. "Role of surfactant protein C in neonatal genetic disorders of the surfactant system." Medicine 100, no. 50 (December 17, 2021): e28201. http://dx.doi.org/10.1097/md.0000000000028201.

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Ovsyannikov, D. Yu, M. A. Zhestkova, V. A. Strelnikova, A. P. Averin, M. A. Atipaeva, O. Yu Brunova, G. V. Buyanova, et al. "Genetic Dysfunctions of the Surfactant System in Children: Results of a Multicenter Study." Doctor.Ru 22, no. 3 (2023): 22–31. http://dx.doi.org/10.31550/1727-2378-2023-22-3-22-31.

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Aim: Genetic, clinical, laboratory-instrumental and morphological characteristics of genetic dysfunctions of the surfactant system in children, therapy and outcomes of the disease. Design: Multicentre, ambispective, open-label, descriptive pilot longitudinal study. Materials and methods. We observed 17 children from 16 families with identified mutations in the SFTPC, ABCA3, NKX2-1 genes. Methods used: genealogical, Sanger sequencing, clinical exome sequencing, computed tomography and histological examination of the lungs. Results. The study included 8 children with congenital deficiency of surfactant protein C, 8 children with brain-lung-thyroid syndrome and 1 patient with congenital deficiency of protein ABSA3. Based on the results of a genetic examination of patients, nucleotide variants c.218T>C were identified in 2 out of 8 patients with a mutation in the SFTPC gene, which is the most common according to the literature. In 5 children, the mutations were hereditary. Congenital deficiency of surfactant protein C, ABCA3 protein and brain-lung-thyroid syndrome were characterized by clinical, computed tomography, and morphological signs of interstitial lung disease. Despite complex respiratory, anti-inflammatory therapy, the frequency of deaths in congenital deficiency of surfactant protein C was 37.5%. Conclusion. Children with severe respiratory distress syndrome of newborns, interstitial lung disease with the development of severe chronic respiratory failure, burdened with a family history should undergo genetic testing to detect mutations in the genes SFTPB, SFTPC, ABCA3. The patient's combination of respiratory symptoms with congenital hypothyroidism and neurological pathology is the basis for genetic examination for NKX2-1 gene mutations to exclude the brain-lung-thyroid syndrome. Keywords: genetic dysfunctions of the surfactant system, congenital deficiency of surfactant protein C, congenital deficiency of ABCA3 protein, brain-lung-thyroid syndrome, NKX2-1 gene, children.

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Moreira, Leonardo Marmo, and Juliana Pereira Lyon. "Interaction between surfactants and proteins." Pubvet 16, no. 5 (May 2022): 1–8. http://dx.doi.org/10.31533/pubvet.v16n05a1115.1-8.

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Several approaches have been focused on the protein-surfactant interaction. Surfactant-protein interactions are very common in the fields of medicine, chemistry, biology etc. Indeed, many aspects of this interaction have been studied, such as the influence of the aggregation state of the surfactant (monomer, pre-micellar aggregate, micelle, and liposomes) on the protein structure, the properties of the surfactant-protein system, the characterization of the interaction sites on the protein surface, the identification of the intermediate protein conformations etc. The interaction of several types of proteins with the different kind of surfactant can furnish various information to the research of biochemical and biophysical systems, such as the structure-activity relationship of proteins as well as the mechanism of interaction between proteins and amphiphilic molecules. In this context, proteins with prosthetic group are very interesting ones, since the presence of the non-amino acid group can furnishes various information through different instrumental techniques of analysis, acting as a label of all polypeptide chains. The present work analyzes this topic and the potential of these studies.

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Kim, Hugh I., Hyungjun Kim, Young Shik Shin, Luther W. Beegle, Seung Soon Jang, Evan L. Neidholdt, William A. Goddard, James R. Heath, Isik Kanik, and J. L. Beauchamp. "Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System." Journal of the American Chemical Society 132, no. 7 (February 24, 2010): 2254–63. http://dx.doi.org/10.1021/ja908477w.

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Matalon, S., V. DeMarco, I. Y. Haddad, C. Myles, J. W. Skimming, S. Schurch, S. Cheng, and S. Cassin. "Inhaled nitric oxide injures the pulmonary surfactant system of lambs in vivo." American Journal of Physiology-Lung Cellular and Molecular Physiology 270, no. 2 (February 1, 1996): L273—L280. http://dx.doi.org/10.1152/ajplung.1996.270.2.l273.

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Nitric oxide (.NO) is a free radical, and as such may damage the pulmonary surfactant system. To determine the potential toxicity of .NO in vivo, we exposed 35 newborn lambs to 0, 20, 80 or 200 ppm .NO in either 21 or 60% O2 for 6 h. At the end of the exposure, lambs had normal values of arterial Po2, Pco2, and pH; total protein concentration in the bronchoalveolar lavage was also at normal levels. There were no differences in the surface properties of surfactant among the air or 60% O2 groups. Pulmonary surfactant samples, isolated from the bronchoalveolar lavage of lambs breathing air or 20 ppm .NO and reconstituted at a lipid concentration of 3 mg/ml, reached a low minimum surface tension (Tmin < 3 mN/m) in a pulsating bubble surfactometer. On the other hand, abnormal surface properties were observed in 36 and 60% of surfactant samples isolated from lungs of lambs that breathed 80 or 200 ppm .NO, respectively. These findings were confirmed using a captive bubble surfactometer. Surfactant protein A, isolated from the lungs of lambs that breathed 200 ppm .NO, exhibited decreased ability to aggregate lipids in vitro. These data are consistent with injury to the surfactant apoproteins during inhalation of either 80 or 200 ppm .NO for 6 h.

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Rodriguez-Capote, Karina, Kaushik Nag, Samuel Schürch, and Fred Possmayer. "Surfactant protein interactions with neutral and acidic phospholipid films." American Journal of Physiology-Lung Cellular and Molecular Physiology 281, no. 1 (July 1, 2001): L231—L242. http://dx.doi.org/10.1152/ajplung.2001.281.1.l231.

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The captive bubble tensiometer was employed to study interactions of phospholipid (PL) mixtures of dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholine (POPC) or 1-palmitoyl-2-oleoyl- sn-glycero-3-[phospho- rac-(1-glycerol)] (POPG) at 50 μg/ml with physiological levels of the surfactant protein (SP) A SP-B, and SP-C alone and in combination at 37°C. All surfactant proteins enhanced lipid adsorption to equilibrium surface tension (γ), with SP-C being most effective. Kinetics were consistent with the presence of two adsorption phases. Under the conditions employed, SP-A did not affect the rate of film formation in the presence of SP-B or SP-C. Little difference in γmin was observed between the acidic POPG and the neutral POPC systems with SP-B or SP-C with and without SP-A. However, γmax was lower with the acidic POPG system during dynamic, but not during quasi-static, cycling. Considerably lower compression ratios were required to generate low γminvalues with SP-B than SP-C. DPPC-POPG-SP-B was superior to the neutral POPC-SP-B system. Although SP-A had little effect on film formation with SP-B, surface activity during compression was enhanced with both PL systems. In the presence of SP-C, lower compression ratios were required with the acidic system, and with this mixture, SP-A addition adversely affected surface activity. The results suggest specific interactions between SP-B and phosphatidylglycerol, and between SP-B and SP-A. These observations are consistent with the presence of a surface-associated surfactant reservoir which is involved in generating low γ during film compression and lipid respreading during film expansion.

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Willems, Coen H. M. P., Luc J. I. Zimmermann, Renate M. R. Langen, Maria J. A. van den Bosch, Nico Kloosterboer, Boris W. Kramer, and J. Freek van Iwaarden. "Surfactant Protein A Influences Reepithelialization in an Alveolocapillary Model System." Lung 190, no. 6 (October 13, 2012): 661–69. http://dx.doi.org/10.1007/s00408-012-9424-6.

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Дисертації з теми "Surfactant-Protein System"

Lim, Boon-Leong. "Cloning and expression of a C1q-binding protein and two of the collections (Collectin-43 and lung surfactant protein D)." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239328.

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Abozaid, Suhair Mohamed. "Studies on the interaction of surfactant protein SP-D with Inflenza A virus, Aspergillus fumigatus and dendritic cells." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13595.

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Surfactant proteins, SP-A and SP-D, are collagen-containing calcium-dependent (C-type) lectins, called, collectins. Their primary structure has four regions: a cysteine-linked N- terminal region involved in multimerization, a collagen region composed of Gly-X-Y repeats, coiled-coil neck region, and the C-terminal carbohydrate recognition domains (CRD) or C-type lectin domain. SP-A looks like a bouquet, while SP-D is a cruciform- like structure, with four arms of equal length. SP-A and SP-D have been shown to act as innate immune molecules at pulmonary as well as extra-pulmonary sites by binding to pathogens, allergens and apoptotic/necrotic cells via their CRD region. SP-A and SP-D can induce pathogen neutralization and enhanced phagocytosis. In addition, SP-A and SP-D can interact via CRDs with allergens and dampen allergic reaction in vitro and in vivo. This thesis examines in vitro interaction of a recombinant fragment of human SP-D containing neck and CRD regions (rhSP-D) with IAV and Aspergillus fumigatus, in addition to characterizing a dichotomy of the effects of SP-A and SP-D on dendritic cells in an attempt to explain how SP-A and SP-D modulate DC functions differentially. Experiments involving interaction of rhSP-D with IAV pandemic strain show that it can be a restrictive factor against the virus, in addition to modulating immune response by a macrophage cell line. The rhSP-D can have anti-A. fumigatus effect directly and indirectly in the context of pathogen as well as allergen. A comparison has been made between two recombinant fragments of SP-D that have been expressed with and without 8 Gly-X-Y repeats for their fungistatic properties. The effects of SP-A and SP-D on cultured DC maturation, and effector cytokine and proliferative response of co-cultured cells have also been examined in vitro.

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Kamalanathan, Ishara Dedunu. "Foam fractionation of surfactant-protein mixtures." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/foam-fractionation-of-surfactantprotein-mixtures(a6484b1a-d796-45ff-bc5c-420ef9130363).html.

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Foam fractionation is an adsorptive bubble separation technology that has shown potential as a replacement to the more costly and non-sustainable traditional downstream processing methods such as solvent extraction and chromatography for biological systems. However biological systems mostly tend to be a mixture of surface active species that complicates the foam fractionation separation. In this thesis a detailed experimental study on the application of foam fractionation to separate a well-defined surfactant-protein mixture was performed with emphasis on the competitive adsorption behaviour and transport processes of surfactant-protein mixtures in a foam fractionation process. Surface tension and nuclear magnetic resonance (NMR) measurements showed that nonionic surfactant Triton X−100 maximum surface pressure, surface affinity and diffusivity were a factor of 2.05, 67.0 and 19.6 respectively greater than that of BSA. Thus Triton X−100 dominated the surface adsorption at an air-water surface by diffusing to the surface and adsorbing at the surface faster than BSA. This competitive adsorption behaviour was observed in foam fractionation experiments performed for Triton X−100/BSA mixtures for different feed concentration ratios and air flow rates. The recovery and enrichment of Triton X−100 were found to increase and decrease respectively with increasing air flow rate for all foam fractionation experiments as expected for a single component system. However the recovery and enrichment of BSA were both found to increase with increasing air flow rate for high feed concentrations of Triton X−100.Bubble size measurements of the foamate produced from foam fractionation experiments showed that at steady state conditions the bubbles rising from the liquid pool were stabilised by BSA. However at the top of the column the recovery of Triton X−100 in the foamate (75% to 100%) was always greater than the recovery of BSA (13% to 76%) for all foam fractionation experiments. In addition, for high feed concentrations of both components and at low air flow rates, the enrichment of BSA remained at almost unity for most experiments and only increased when the recovery of Triton X−100 reached 100%. Thus it was concluded that Triton X-100 displaced the adsorbed BSA from the surface. The foam drainage properties of Triton X−100/BSA mixtures were characterised using two methods; forced foam drainage and from pressure profiles of steady state foam fractionation experiments (pressure method). The drainage data from the forced foam drainage was found not to be compatible with experimental foam fractionation results, by indicating that stable foam was not produced during the foam fractionation experiments. However stable foam was repeatedly produced during foam fractionation experiments. The drainage data from the pressure method was found to be in close agreement to experimental foam fractionation experiments. The work in this thesis takes a significant step beyond the literature experimental foam fractionation studies for multicomponent systems. In addition to investigating the effect of foam fractionation process parameters on the separation of mixed systems, the results from the characterisation studies of surface adsorption and foam properties provided insight and deeper understanding of the competitive adsorption behaviour of surfactants and proteins in a foam fractionation process.

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Rickard, Deborah. "Multiphase, Multicomponent Systems: Divalent Ionic Surfactant Phases and Single-Particle Engineering of Protein and Polymer Glasses." Diss., 2011. http://hdl.handle.net/10161/3934.

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This thesis presents an analysis of the material properties and phase behavior of divalent ionic surfactant salts, and protein and polymer glasses. There has been extensive interest in understanding the phase behavior of divalent ionic surfactants due to the many applications of ionic surfactants in which they come into contact with divalent ions, such as detergency, oil recovery, and surfactant separation processes. One goal of determining the phase boundaries was to explore the option of incorporating a hydrophobic molecule into the solid phase through the micelle-to-crystal bilayer transition, either for drug delivery applications (with a biologically compatible surfactant) or for the purpose of studying the hydrophobic molecule itself. The liquid micellar and solid crystal phases of the alkaline earth metal dodecyl sulfates were investigated using calorimetry, visual inspection, solubilization of a fluorescent probe, and x-ray diffraction. The Krafft temperature and dissolution enthalpy were determined for each surfactant, and partial composition-temperature phase diagrams of magnesium dodecyl sulfate-water, calcium dodecyl sulfate-water, as well as sodium dodecyl sulfate with MgCl₂ and CaCl₂ are presented. As a proof of concept, fluorescence microscopy images showed that it is, in fact, possible to incorporate a small hydrophobic molecule, diphenylhexatriene, into the solid phase.

The second, and main, part of this thesis expands on work done previously in the lab by using the micropipette technique to study two-phase microsystems. These microsystems consist of a liquid droplet suspended in a second, immiscible liquid medium, and can serve as direct single-particle studies of drug delivery systems that are formed using solvent extraction (e.g., protein encapsulated in a biodegradable polymer), and as model systems with which to study the materials and principles that govern particle formation. The assumptions of the Epstein-Plesset model, which predicts the rate of droplet dissolution, are examined in the context of the micropipette technique. A modification to the model is presented that accounts for the effect a solute has on the dissolution rate. The modification is based on the assumption that the droplet interface is in local thermodynamic equilibrium, and that the water activity in a solution droplet can be used to determine its dissolution (or dehydration) rate. The model successfully predicts the dissolution rates of NaCl solutions into octanol and butyl acetate up to the point of NaCl crystallization. The dehydration of protein solutions (lysozyme or bovine serum albumin) results in glassified microbeads with less than a monolayer of water coverage per protein molecule, which can be controlled by the water activity of the surrounding organic medium. The kinetics of dehydration match the prediction of the activity-based model, and it is shown how the micropipette technique can be used to study the effect of dissolution rate on final particle morphology. By using a stable protein with a simple geometry (lyosyzme), this technique was be used to determine the distance dependence of protein-protein interactions in the range of 2-25 Å, providing the first calculation of the hydration pressure decay length for globular proteins. The distance-dependence of the interaction potential at distances less than 9 Å was found to have a decay length of 1.7 Å, which is consistent with the known decay length of hydration pressure between other biological materials. Biodegradable polyesters, such as poly(lactide-co-glycolide) (PLGA), are some of the most common materials used for the encapsulation of therapeutics in microspheres for long-term drug release. Since they degrade by hydrolysis, release rates depend on water uptake, which can be affected by processing parameters and the material properties of the encapsulated drug. The micropipette technique allows observations not possible on any bulk preparation method. Single-particle observations of microsphere formation (organic solvent extraction into a surrounding aqueous phase) show that as solvent leaves the microsphere and the water concentration in the polymer matrix becomes supersaturated, water phase separates and inclusions initially grow quickly. Once the concentration in the polymer matrix equilibrates with the surrounding aqueous medium, the water inclusions continue to grow due to dissolved impurities, solvent, and/or water-soluble polymer fragments resulting from hydrolysis, all of which locally lower the water activity in the inclusion. Experiments are also presented in which glassified protein microbeads were suspended in PLGA solution prior to forming the single microspheres. This technique allowed the concentration of protein in a single microbead/inclusion to be determined as a function of time.

Dissertation

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Частини книг з теми "Surfactant-Protein System"

Karbani, Najmunisa, Eswari Dodagatta-Marri, Asif S. Qaseem, Priyaa Madhukaran, Patrick Waters, Anthony G. Tsolaki, Taruna Madan, and Uday Kishore. "Purification of Native Surfactant Protein SP-A from Pooled Amniotic Fluid and Bronchoalveolar Lavage." In The Complement System, 257–72. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-724-2_21.

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Dodagatta-Marri, Eswari, Asif S. Qaseem, Najmunisa Karbani, Anthony G. Tsolaki, Patrick Waters, Taruna Madan, and Uday Kishore. "Purification of Surfactant Protein D (SP-D) from Pooled Amniotic Fluid and Bronchoalveolar Lavage." In The Complement System, 273–90. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-724-2_22.

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Arai, S., and M. Watanabe. "An Enzymatically Modified Protein as a New Surfactant and its Function to Interact With Water and Oil in an Emulsion System." In Properties of Water in Foods, 49–64. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5103-7_4.

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T.A. Qashqoosh, Mohsen, Faiza A.M. Alahdal, Yahiya Kadaf Manea, Swaleha Zubair, and Saeeda Naqvi. "Influence of Tween 80 Surfactant on the Binding of Roxatidine Acetate and Roxatidine Acetate–loaded Chitosan Nanoparticles to Lysozyme." In Surfactants [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100734.

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The drug binding to protein is an attractive research topic. In order to assess the release of RxAc-CsNPs and their binding with lysozyme under physiological conditions, nanocomposite materials based on chitosan (Cs) and Roxatidine acetate (RxAc) in the presence Tween 80 (Tw80) surfactant were developed. The addition of Tw80 to CsNPs increased RxAc release in vitro. In this work, Stern–Volmer plot and thermodynamic results indicated that the mechanism of Lyz with RxAc and Lyz with RxAc-CsNPs was static mechanism and the main forces in both systems were hydrogen bonding and Van der Waals forces, which indicated that the binding reaction in both systems is spontaneous, exothermic and enthalpically driven. Synchronous fluorescence and CD results indicated that the RxAc and RxAc-CsNPs cause change in the secondary construction of Lyz. It was also found that the addition of Tw80 affects the binding constant of drug with protein. Finally, the molecular docking results have also been in accordance with the results of other techniques. Hence, the developed RxAc loaded Chitosan nanoparticles could be used as an effective strategy for designing and application of the antiulcer drugs. Altogether, the present study can provide an important insight for the future designing of antiulcer drugs.

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Dhariwal, Jyoti, Gaurav Choudhary, Dipti Vaya, Srikanta Sahu, Manish Shandilya, Poonam Kaswan, Ambrish Kumar, Shruti Trivedi, Manoj K. Banjare, and Kamalakanta Behera. "Self-Assembled Nanostructures within Ionic Liquids-based Media." In Ionic Liquids: Eco-friendly Substitutes for Surface and Interface Applications, 111–59. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815136234123010011.

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Ionic liquids (ILs) have shown immense potential as suitable alternatives to environmentally damaging volatile organic solvents (VOS). These unique materials possess very unusual physicochemical properties, such as low melting point, high boiling point, excellent thermal and chemical stability, large electrochemical window, very low volatility and high conductivity. One of the most important features associated with ILs is that their physicochemical properties, like viscosity, density, hydrophobicity, solubility, polarity, etc., can be effectively tuned for desired applications just by tuning the structures of cations and/or anions. Further, these designer solvents show dual behavior, i.e., electrolytes and solvents. In the last two decades, these unique materials have shown tremendous application potential in various interdisciplinary research areas, such as synthesis, catalysis, separation, extraction, nanoscience, and pharmaceutics, among many others. Further, the formation of surfactant self-assembled nanostructures (micelles and microemulsions (ME)) within ionic liquid-based systems of immense importance due to the vast utility of these nanostructures well as ILs in various fields of science and technology. These microheterogeneous systems can be effectively used as greener alternatives to those environmentally harmful volatile organic solvents which are largely used for academic and industrial research purposes.atile organic solvents which are largely used for academic and industrial research purposes. The IL-based self-assembled nanostructures show major advantages due to their affinity to solubilize many chemical and biochemical solutes (both hydrophilic as well as hydrophobic), thereby expanding their potential application as solubilizing media, media for synthesis, catalysis and biocatalysis, separation and extraction, drug delivery vehicles, and media for biochemical stability (e.g., protein and enzyme stability). This book chapter will highlight the formation and utility of various types of self-assembled nanostructures formed by surfactants, polymers, etc., within Ils-based media.

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Тези доповідей конференцій з теми "Surfactant-Protein System"

Kim, D., S. Q. Tia, M. He, and A. E. Herr. "Microfluidic Western blotting: Cationic surfactant based protein sizing integrated with electrostatic immobilization." In 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2011. http://dx.doi.org/10.1109/memsys.2011.5734395.

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Simion, Demetra, Carmen Gaidău, Mariana Daniela Berechet, Maria Stanca, Cosmin Alexe, and Gabriela Păun. "The Influence of Surfactants in Obtaining New Byproducts, for Agriculture Applications." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.24.

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The aim of the paper is to obtain new byproducts based on surfactants (gemini – polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides or bolaform – demecarium bromide) and protein hydrolysates (keratin and collagen) with micro and macro nutrients for applications in agriculture. A method was developed to include micro and macronutrients in keratin and collagen hydrolysates, in order to obtain new byproducts-bioemulsions (stable because of surfactants), with final goal of application as a new class of root fertilizers for cereals (e.g., corn). The newly obtained byproducts (bioemulsions based on surfactants) were characterized by: dynamic light scattering measurements, contact angle, optical microscopy and microbiological tests against fungal attack of Fusarium spp. and Botrytis cinerea. Better results were obtained for gemini surfactant based on sugar – polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides) due to the properties such as: biodegradability, nontoxicity and adherence to surfaces. The new fertilizer created in this research – bioemulsions based on surfactants, can support the general structure of the grains as well as the chlorophyll content, increasing the growth yield. The fertilizer is indicated for any type of crops and soils, with recommended use as additional fertilizer for plants (cereals) in the vegetation and growth phases, with a maximum need for nutrients.

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Quan, Glen Lelyn, Kentaro Matsumiya, Michiaki Araki, Yasuki Matsumura, and Yoshihiko Hirata. "The role of sophorolipid as carrier of active substances." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/hnkx3869.

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Sophorolipid is a glycolipid-type biosurfactant, produced from natural sources by fermentation with a nonpathogenic yeast Starmerella bombicola. Its structure is composed of 2 hydrophilic parts, a sophorose unit, a glucose disaccharide glycosically linked to a hydroxyl fatty acid. Its structure spontaneously forms a vesicle of about 100 nm in an aqueous solution, which is similar to that of liposomes used as drug delivery systems and transdermal absorption promoters. It can be expected to have an effect of promoting permeation of active substances such as lactoferrin. Lactoferrin is an iron-binding glycoprotein having a molecular weight of about 80 kDa, and is most abundant in breast milk in the living body. Since it is also present in amniotic fluid that protects the mother and fetus, it is important to study the physiological relationship between skin and lactoferrin. The transdermal administration of lactoferrin with sophorolipid was verified, followed by the investigation protein-surfactant interactions between bovine lactoferrin and sophorolipid. Structural changes were further observed using spectroscopic, microscopic and biochemical methods under weakly acidic and neutral pH conditions. From particle size analysis by dynamic light scattering, microscopic observation by cryo-SEM, and digestion pattern observation by enzyme treatment, it was confirmed that bovine lactoferrin and sophorolipid interact with each other to form a sheet and nanometer-sized coagulation at pH 5.0 and 7.0 forming an aggregate, which was considered to be due to the self-organizing structure characteristic of sophorolipid. It can be concluded that sophorolipid has a potential of being a transport carrier of active substances, which can have vast applications not only in cosmetics but in drug delivery systems as well. Biosurfactants and biopolymers: Between interactions, orthogonality and mutual

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