Дисертації з теми "Supportive medicines in cancer"
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du, Plessis Johannes. "Family experiences and viewpoints of palliative and supportive care for children with cancer: Can we do better?" Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25066.
Повний текст джерелаFarley, Amanda Claire. "Health and supportive care needs of surgical lung cancer patients, and the prognostic significance of smoking." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4979/.
Повний текст джерелаWong, Margurite Elvina. "Supporting Chinese-speaking cancer patients to make safe and informed complementary medicine decicions." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42129.
Повний текст джерелаSalas-Vega, Sebastian. "Cancer medicines : clinical impact, economics, and value." Thesis, London School of Economics and Political Science (University of London), 2017. http://etheses.lse.ac.uk/3647/.
Повний текст джерела譚郭雅欣 and Gloria Tam. "Non-small cell lung cancer clinical trials on new medicines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41711956.
Повний текст джерелаFang, Rui. "Investigation of some traditional Chinese medicines used to treat cancer." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/investigation-of-some-traditional-chinese-medicines-used-to-treat-cancer(c889892f-19cd-4a7a-908c-faaeec106eb7).html.
Повний текст джерелаTam, Gloria. "Non-small cell lung cancer clinical trials on new medicines." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41711956.
Повний текст джерелаBeesley, Vanessa Lea. "The experience of gynaecological cancer survivors : supportive care needs and use." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16355/1/Vanessa_Beesley_Thesis.pdf.
Повний текст джерелаBeesley, Vanessa Lea. "The experience of gynaecological cancer survivors : supportive care needs and use." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16355/.
Повний текст джерелаGardner, Robert B. "A Holistic Assessment of the Perceived Supportive Care Needs of Cancer Patients during Treatment." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/823.
Повний текст джерелаEvans, Maggie. "The role of holistic assessment in the supportive care of patients with cancer." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508057.
Повний текст джерелаBuchanan, Deans. "The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/43cf70da-fac1-41d5-be95-213521128c52.
Повний текст джерелаCoyle, C. "Repurposing medicines for the adjuvant treatment of cancer : an evaluation of aspirin and metformin." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10050892/.
Повний текст джерелаFerrario, Alessandra. "Access to cancer medicines in Europe : an analysis of existing challenges and countries' responses." Thesis, London School of Economics and Political Science (University of London), 2016. http://etheses.lse.ac.uk/3535/.
Повний текст джерелаAkuoko, Cynthia Pomaa. "Exploring health service and supportive care needs of women with advanced breast cancer in Ghana." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211292/1/Cynthia_Akuoko_Thesis.pdf.
Повний текст джерелаCollett, Joan M. "Oncology Nurses' Impact Scores for Obstacles and Supportive Behaviors at the End of Life." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2673.
Повний текст джерелаMcCallum, Megan. "Gynecological Cancer: Practical Implications for Identifying and Meeting Supportive Care and Sexual Health Needs After Treatment." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26282.
Повний текст джерелаJohnson-Ajinwo, Okiemute Rosa. "Identification, semi-synthesis and evaluation of anti-ovarian cancer compounds from plants used in traditional medicines." Thesis, Keele University, 2017. http://eprints.keele.ac.uk/3773/.
Повний текст джерелаChawatama, Brighton Itayi. "Knowledge-based integration of Zimbabwean traditional medicines into the National Healthcare System: A case study of prostate cancer." University of the Western Cape, 2017. http://hdl.handle.net/11394/7009.
Повний текст джерелаThis study sought to identify the bottlenecks in the promotion of Zimbabwean Traditional Medicines (ZTMs) towards improving the national healthcare delivery system. The indigenous medicines lost value and recognition to the Conventional Western Medicines introduced by the British colonialist since 1871 and is still dominating the national healthcare delivery system. There are growing challenges to ensure accessibility of affordable drugs especially for primary healthcare. The World Health Organization (WHO) and United Nations (UN) is in support of re-engaging indigenous medical interventions to achieve the Millennium development goals. Indigenous Traditional Medicine Knowledge-Based Systems (ITMKS) form the basis of the main source of health care for about 80% of the population in the developing countries. The implementation of the Zimbabwe Traditional Medicines Policy (ZTMP) has been at a stand-still since inception in 2007. The research used mixed methods involving qualitative and quantitative approaches. Data was collected through desk and field research. Questionnaires and focus group discussions were used to record perceptions and attitudes of key informants. The stakeholders included Traditional Health Practitioners (THPs), Medical Doctors, Pharmacists, Medical Research Council of Zimbabwe (MRCZ) staff, Medicines Control Authority of Zimbabwe (MCAZ), Traditional Medical Practitioner’s Council (TMPC), Zimbabwe National Traditional Healers Association (Zinatha), Ministry of Health and Childcare, WHO, Higher Education Institutions (UZ School of Pharmacy staff and students), Christian Groups, NGOs and Prostate Cancer Patients in Harare CBD. The stakeholders sampling framework was obtained from the list of registered practitioners. The stakeholder mapping involved selection of 5 key informants from each focus group obtained through random selection. The Snowball sampling technique was used to follow the closest 5 key informants in each focus group. The key findings established that 80% of respondents agreed to the integration of ZTM. The major bottlenecks were lack of modern dosage forms and standardization to determine quality, safety and efficacy of the ZTM. The study suggests that in order to fast track the integration process, a bottom up implementation strategy providing ZTM advocacy, capacity building in the institutionalization and training of ZTMPs, pharmacists and CMP need to be engaged for a favorable and quick buy-in. The study also recommends further analysis of the Indigenous Knowledge Systems (IKS) areas of specialization in pharmaceutical practice in order to improve treatment outcomes.
Perone, Jennifer A., Taylor S. Riall, and Kelly Olino. "Palliative Care for Pancreatic and Periampullary Cancer." W B SAUNDERS CO-ELSEVIER INC, 2016. http://hdl.handle.net/10150/622658.
Повний текст джерелаMorris, Sara Margaret. "The dialogue of support : in the context of supportive health care services for women recently diagnosed with breast cancer." Thesis, Lancaster University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286987.
Повний текст джерелаAu, Ho-yee Angel, and 區可兒. "What are the unmet supportive care needs among Hong Kong Chinese womenwith advanced breast cancer?: do they changeover time?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48521814.
Повний текст джерелаpublished_or_final_version
Community Medicine
Master
Master of Philosophy
Frode, Linda, and Håkan Marsh. "Faktorer som påverkar deltagande : Psykosocialt stöd vid prostatacancer." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165519.
Повний текст джерелаSyfte: Syftet med detta arbete var att se om olika faktorer kunde påverka deltagande i stödverksamhet efter att patienten fått diagnosen prostatacancer, samt vilken form av psykosocialt stöd patienterna föredrar. Metod: Metoden som använts var en enkätstudie med både kvantitativ ansats, som delades ut under hösten 2011 till prostatacancerpatienter på urologmottagningen, Akademiska sjukhuset. Huvudresultat: Män anger att de inte är intresserade av att delta i stödverksamhet efter diagnos och eventuell behandling. Vid behov ansåg de att enskilda eller gruppsamtal var mest relevanta som stödverksamheter. Informanterna ansåg att rehabilitering med samtal och yoga hade minst relevans. Slutsats: Män som drabbats av prostatacancer väljer att inte delta i stödverksamhet. Behov finns därför av att utföra mer studier för att klargöra orsakerna till detta.
Oliveira, Carla Maria da Costa. "Fitoterapia na prevenção do cancro." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4182.
Повний текст джерелаA Fitoterapia é uma terapêutica não convencional que tem vindo, ao longo das últimas décadas, a despertar o interesse da comunidade geral e científica, nomeadamente pelo seu possível papel na prevenção do cancro. Esta patologia constitui, ainda, uma das principais causas de morte no mundo. Algumas plantas têm demonstrado um potencial papel preventivo na ocorrência e/ou progressão do cancro (tal como outras doenças crónicas). Na primeira parte deste trabalho, apresenta-se uma abordagem aos conceitos de Fitoterapia, fitofármaco e fitoterápico. Segue-se uma perspetiva histórica do conceito de fitoterapia, evidenciando o crescente interesse demonstrado pela comunidade geral e científica nesta área. Como consequência deste interesse generalizado expõem-se, em seguida, aspetos importantes relacionados com a qualidade, eficácia e segurança na utilização de plantas medicinais, ou seja, critérios específicos e questões legais que envolvem e regem o seu uso. Na segunda parte desta contextualização teórica, apresenta-se uma breve exposição sobre o cancro e de seguida descreve-se, com base numa revisão da literatura, o impacto das plantas medicinais na prevenção desta patologia. No terceiro ponto, são analisadas pormenorizadamente as plantas com maior impacto na prevenção do cancro. Sobre as mesmas abordar-se-ão os seus compostos ativos, os mecanismos de ação subjacentes, efeitos secundários, interações com fármacos e, por fim, a respectiva influência na prevenção do cancro. Phytotherapy is an unconventional therapy that has, over the past decades, to arouse the interest of the scientific community generally and especially for its implication in cancer prevention. This pathology is also a major cause of death all over the world. Some plants have demonstrated a potential preventive role in the occurrence and/or progression of cancer (such as other chronic diseases). The first part of this work, consists of an approach to the concepts of phytotherapy, herbal medicine and phytochemical. Then follows a historical perspective of the concept of herbal medicine, highlighting the growing interest shown by the general community and this area. As a result of the widespread interest on phytotherapy, important aspects related to the quality, efficacy and safety in the use of medicinal plants, ie, specific criteria and legal issues that surround and govern your use were addressed. In the second part of this study, a brief exposition of the cancer is presented and then described, based on a literature review, the impact of medicinal plants in the prevention of this disease. Finally, the plants with the greatest impact on cancer prevention, we analyzed in detail. Namely, the active compounds, the effects, drug interactions, and ultimately, their influence on cancer prevention.
Burt, Stephanie. "Re-Branding Palliative Care: Assessing Effects of a Name Change on Physician Communicative Processes During Referrals." Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc67964/.
Повний текст джерелаRobson, E. "Taking a holistic approach to supportive cancer care : a qualitative study exploring patients' experiences and perceived impact of attending a wellbeing group." Thesis, City, University of London, 2018. http://openaccess.city.ac.uk/20186/.
Повний текст джерелаCOSTA, GIULIO. "FROM THE PSYCHOLOGICAL ASSESSMENT TO THE SUPPORTIVE-EXPRESSIVE GROUP THERAPY FOR WOMEN WITH BREAST CANCER AND THEIR CAREGIVERS. A MULTI-METHOD DESIGN." Doctoral thesis, Università Cattolica del Sacro Cuore, 2008. http://hdl.handle.net/10280/330.
Повний текст джерелаThis dissertation examines the psychological assessment for women with breast cancer and their chosen caregivers. It will be wholly presented the longitudinal research design in which the three studies of this dissertation are included. The first study aims not only to standardize the sampling procedure, but it also has the clinical purpose to verify whether coping strategies and interpersonal adjustment preedict end moderate the acceptance to a Supportive-Expressive Group Therapy (SEGT). In the second study the unit of analysis is the couple, which allows for a more accurate description of dyadic coping processes. It will be described and examined specifics couple's typologies or couple matching depending on symptoms and psychological factors such as, life orientations, depression and personality traits. The third study is totally centred on the SEGT. It will be described the nature of intervention and the structure of each session, exploring how the contents and the styles of the therapeutic action change.
Scotté, Florian. "Description et évolution de l'organisation entre les phases curatives et palliatives autour des soins et de la iatrogénie : Les soins de support en cancérologie." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T055.
Повний текст джерелаThe management of a cancer patient requires, to the caregivers, finding the best antineoplastic therapy in combination with support involvement from the diagnosis to the stage after cancer or death. During the course of care, patient and family will be confronted with different teams, different visions and different treatment approaches of their care. The work presented starts threw an analysis of French organizations of supportive care and management of iatrogenic effects due to three main types of symptomatic therapeutics: erythropoietins, bisphosphonates and opioids. Based on this photograph of accompanying cancer care, the development in an institution of an health care will be presented for ambulatory management of day hospital for chemotherapy administration, until full hospitalization in a pilot unit. The link, the differences and complementaries between the teams in curative and palliative phases will be discussed to define the role and importance of the overall look and unifying supportive care in oncology
Vieira, Henry Walber Dantas. "Validade de Constructo do Supportive care needs survey-short form 34 (SCNS-SF34) para a avaliação das necessidades de cuidados em pacientes oncológicos atendidos em Manaus." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-14072017-110913/.
Повний текст джерелаIntroduction: With the increase of cancer cases worldwide, validated and reliable instruments to assess care needs of oncologic patients are fundamental in offering proper services to people with cancer. Objective: To analyze evidence of validity of the Brazilian version of the Supportive Care Needs Survey - Short Form 34 (SCNS-SF34) in assessing the oncological healthcare needs of patients assisted in Manaus. Methods: A methodological study with a convenience sample composed of 691 adult cancer patients, assisted at Fundação Centro de Controle de Oncologia do Estado do Amazonas (FCECON), from April to July 2016. The source of information for the data collection was a form with sociodemographic and clinical data, as well as, the SCNS-SF34 survey approved for Brazilian Portuguese. For the sample, 20 patients were considered for each item of SCNS-SF34. A total of 691 patients were divided into two sub-samples (Sample A=350 and Sample B=341) for the psychometric analysis. The t student test was used to compare sociodemographic and clinical variables (sex, age group, treatment time) and SCNS-SF34 total score. Exploratory factor analysis (EFA) and Confirmatory factor analysis (CFA) were performed by using statistical software FACTOR 10.3. In order to calculate internal consistency, the Cronbach\'s alpha was performed and the statistical software Mplus 7.3 was used to evaluate the invariance of the factorial model across gender (male vs female), age group (adult vs elderly) and length of treatment ( 6 vs 6 months). The convergent validity analysis of SCNS-SF34 was performed with the Katz index for daily life activity. Results: Out of 691 patients, the majority (92.6%) were from the state of Amazonas, of which 68.2% were from the city of Manaus. The patients were female (72.6%), with an age < 60 (64.4%), a mean age 53.7 ± 13.28, lived with companion (54.5%) and did not need caregivers (55.3%). The most frequent tumor was located in the male and female reproductive systems (55.6%), with the predominance of female breast cancer (33.9%), followed by the digestive system (17.7%) with tumors of the stomach (6.3%). Regarding treatment, the majority of patients underwent surgery (56.1%) and chemotherapy (60.8%), and the diagnostic and treatment time six months was, respectively, 74.4% and 54.4%. The total mean score of the scale was 76.06 ± 23.50, with a minimum of 35 and a maximum of 170, given that adult patients had a higher need for care than the elderly, respectively, 77.7 ± 23.79 and 72.97 + 22.74 points (p = 0.010). According to the SCNS SF-34 the patients presented low level of supportive care needs. After EFA and CFA, the scale consisted of 34 items and four domains: Physical and daily life (items 1-5), Psychological (6-14 and 17) and Sexuality (15, 16 and 31). The items 18 and 19 were grouped into the domain called Care and Support (21-30 and 32-33). The adjustment indexes obtained through the AFC for the new model (X2 = 1828,981; df = 520; X2/df = 3,51, p<0,001; CFI = 0,926; TLI= 0,918; RMSEA = 0,084 (I.C. 90%= 0,082 - 0,090) were classified as good. The invariance analysis across the different groups (sex, age group and treatment time) was invariant for all groups, without affecting the indices at any of the levels of invariance. The convergent validity between the domains of SCNS-SF34 and Katz Index for daily life activity was statistically significant. Conclusion: The SCNS SF-34, composed by four domains and thirty-four 34 items, has proved to be a valid and reliable instrument to measure the healthcare needs of cancer patients assisted in the city of Manaus, Amazonas, regardless of sex, age group and treatment time. However, the factor structure found is still capable of improvements to the best fit of the model. The use of the SCNS-SF-34 in the clinical settings can contribute to improve the quality of care for this group of patients.
Baudry, Anne-Sophie. "Compétences émotionnelles et besoins en soins de support des proches-aidants en oncologie." Thesis, Lille 3, 2019. http://www.theses.fr/2019LIL3H007/document.
Повний текст джерелаCancers causes a disruption in the lives of patients and their caregivers. They must assume new responsibilities that can lead to health problems, altered quality of life, and adjustment difficulties (e.g., impaired emotional, physical, social, and professional functioning, somatic symptoms, emotional distress). Thus, caregivers need support from health professionals to cope with their role but they frequently report unmet supportive care needs. This thesis work is a part of a more global research program and aims to better understand the supportive care needs of caregivers of cancer patients and their determinants, in particular through emotional processes. The first study of this work validated the French version of a scale assessing the unmet supportive care needs of caregivers of cancer patients. The second study identified profiles of caregivers at higher risk of having at least one moderate or high unmet supportive care need from intrapersonal factors (i.e. emotional distress) and socio-demographic and medical variables (e.g., age of patients and caregivers, metastatic cancer). Finally, the third study tested the theoretical model of the thesis work, already validated for cancer patients, which considers that the emotional competence of caregivers can reduce their unmet supportive care needs by reducing their anxiety and depression symptoms. The results highlight the importance of identifying and addressing the unmet supportive care needs of caregivers, especially related to cancer care, information, and psychological and emotional support. Some profiles of caregivers may represent a population at higher risk of having difficulties and requiring more attention from professionals. Finally, taking into account emotional processes, including emotional competence and anxiety and depression symptoms, may be essential in the supportive care of caregivers
Suissa, Veronique. "Médecine non-conventionnelle et psycho-oncologie : évaluation de l’impact des Médecines Complémentaires et Alternatives (MCA) chez les patients atteints de cancer." Thesis, Paris 8, 2017. http://www.theses.fr/2017PA080066/document.
Повний текст джерелаThis study examines the unconventional movement in Oncology and aim to assess the impact of CAM jointly in terms of benefits, of risks and derivatives in patients with cancer.Our comparative approach explores the experience of 32 patients using or not the CAM of complementary or alternative to curative treatments. A unique semi directive interview was conducted with each patient in order to identify common and distinct processes between differents groups. A questionnaire booklet was also been handed them to end to account characteristics of the unconventional movement.Analysis of the speech shows that the use of CAM affects positively the experience of the illness across the dimensions of the person, but deteriorates the representation of allopathic medicine and the patient-caregiver relationship. The refusal of curative treatments among users of CAM is linked to a universe of disabling beliefs they develop.The analysis of scales suggests that the use of CAM improves the perception of global health, reduces the depressive symptomatology, but has no effect on anxiety. The alternative use of CAM is related to internal causal attribution and control beliefs, but not to control over the course of the disease. The integration of CAM in oncology appears relevant and necessary to improve the care of patients, but should be able to be deployed with caution and progressively in the light of the risks and derivatives of certain heterodox practices
Paterson, Catherine I. E. "Exploring prostate cancer survivors' self-management behaviours and social supportive experiences using questionnaires and electronic behavioural diaries : does social support buffer the relationship between coping and health-related quality of life?" Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/22089faa-ef63-420f-92df-72ff81ce4a14.
Повний текст джерелаRiechelmann, Rachel Simões Pimenta [UNIFESP]. "Risco de interações medicamentosas em pacientes com câncer e recebendo cuidados de suporte exclusivo." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/10066.
Повний текст джерелаUm número desconhecido de pacientes com câncer experimenta reações e interações de drogas graves, podendo resultar em hospitalização e até em morte. Particularmente, pacientes portadores de neoplasia maligna comumente recebem um grande número de medicamentos, além de receberem drogas com alto risco de efeitos adversos. Desta forma, dois estudos foram realizados como base para esta tese: uma revisão sistemática e em estudo retrospectivo. A revisão sistemática da literatura avaliou os estudos publicados sobre a epidemiologia de interações medicamentosas em pacientes com câncer. A busca identificou 8 estudos: 7 artigos publicados no PubMed e um resumo publicado nos proceedings do congresso da sociedade americana de oncologia (ASCO). A maioria dos estudos era retrospectiva e avaliou potenciais interações medicamentosas, com apenas dois estudos publicados sobre reais interações medicamentosas. Aparentemente, um terço dos pacientes oncológico ambulatoriais recebe combinações de drogas com risco de interação. Os principais fatores de risco para interações medicamentosas são: idade avançada, número crescente de medicações, presença de lesões cerebrais (primárias ou secundárias) e pacientes que recebem drogas consideradas de risco como anticonvulsivantes, varfarina e anti-inflamatórios hormonais e não-hormonais. O segundo estudo desta tese avaliou a prevalência de potenciais interações medicamentosas entre pacientes com câncer terminal. Desta forma, nós revisamos retrospectivamente os prontuários de todos os pacientes com câncer que foram atendidos no ambulatório de Cuidados Paliativos, do Hospital Princess Margaret, Toronto, Canadá, num período de 8 meses. As listas de medicações foram rastreadas para interações pelo programa eletrônico Drug Interaction Facts, que classifica as interações por nível de gravidade (maior, moderada e menor) e evidência científica (1 a 5, onde 1 = maior nível de evidência). Dentre os 372 pacientes avaliados, 250 interações medicamentosas potenciais foram identificadas em 115 pacientes (31%, 95% Intervalo de Confiança 26 - 36%), predominantemente envolvendo varfarina e fenitoína. A maioria das potenciais interações foi classificada como de gravidade moderada (59%) e 41,5% possuíam níveis de evidência 1-3. Na análise multivariada, idade crescente (p<0,001), pelo menos uma comorbidade (p=0,001), tipo de câncer (tumores cerebrais, p<0,001) e número crescente de medicamentos utilizados (p<0,001) foram associados a risco de interações medicamentosas. Portanto, concluiu-se que potenciais interações medicamentosas são comuns entre pacientes oncológicos que estejam recebendo cuidados de suporte exclusivos, sendo que a maioria envolve varfarina e/ou anticonvulsivantes. Fatores de risco incluem idade avançada, pacientes com múltiplas comorbidades, tumores cerebrais e aqueles que utilizam muitas medicações.
Background: Drug-drug interactions (DDIs) comprise an important problem in medical oncology practice. We systematically reviewed the frequency of DDIs in oncology. Methods: We searched PubMed for eligible articles and online databases abstracts of major oncology meetings. Results: Eight studies reported on the frequency of DDIs: six evaluated the frequency of potential DDIs while 2 studies reported on real DDIs, i.e. interactions that had clinical consequences. Studies of potential DDIs found that approximately one third of patients are exposed to dangerous drug doublets, with the most common ones involving warfarin and anticonvulsants. One study of real DDIs found that 2% of hospitalized cancer patients had a DDI as the cause of admission. Conclusion: Drug interactions comprise an important issue in oncology, with approximately one third of ambulatory cancer patients being at risk of DDIs. Data are limited on the clinical consequences of drug interactions among cancer patients.
TEDE
BV UNIFESP: Teses e dissertações
Jacquinot, Quentin. "Bénéfices d’un programme de réentrainement à l’effort chez des patientes atteintes d’un cancer du sein HER2-positif, en cours de traitement par trastuzumab en adjuvant. : impact sur la toxicité cardiaque, le déconditionnement, la fatigue et la qualité de vie relative à la santé." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCE021.
Повний текст джерелаOverexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer is associated with poor prognosis. Trastuzumab improves overall survival but it is associated with cardiotoxicity, including a decrease in left ventricular ejection fraction (LVEF). The objective of this thesis work was to evaluate, in patients followed in medical oncology for HER2-positive breast cancer, and treated exclusively with trastuzumab, the effects of a supervised, tailored exercise program (55 minutes, 3 days/week, 12 weeks), combining moderate and high intensities, on cardiotoxicity, as assessed by LVEF and left ventricular longitudinal deformation (LVLD) measured by echocardiography; and on cardiorespiratory fitness, fatigue, pain and health-related quality of life (HRQoL). Fifty-eight patients were randomized into two groups: control (CG, n=28, 49.9±9 years) and training (TG, n=30, 50.4±7.8 years). All variables were analyzed pre- (T0) and post-intervention (T3) and 3 months later (T6). At T0, VO2 peak (mL.min-1.kg-1), measured by a maximal graded exercise, was low in both groups (GE: 24.7 ± 1.4 and GC: 23.8 ± 1.3) without the difference being significant. At T3, LVEF and LVLD did not decrease compared to baseline values. The percentage of patients who did not have cardiac toxicity was greater in the TG (89.3%) than in the CG (84%). In those who developed cardiotoxicity (n=7), LVEF decreased by 10.8% at T3. Maximal workload (MW), VO2 peak and VO2/HR were greater compared to values recorded at T0. Training improves aerobic capacity highlighted by delayed onset of both ventilatory thresholds with higher average workload and VO2 in the TG. Lactatemia was not significantly different but the MW was greater than those developed in pre-training, indicating lower metabolic acidosis. Training intensities increased from 70 to 87 W at base and from 92 to 110 W at peak. In addition, scores for general and physical fatigue, interference and pain intensity decreased, and those for HRQoL increased. Improvements in MW and VO2 peak were associated with less general fatigue, lower pain interference and better HRQoL. Finally, no variable was associated with the scores of the various dimensions of the QLQ-C30, except for age, which was significantly associated with the "fatigue" dimension (OR: 0.081, 95% CI [0.007-0.893]; p<0.04). Accordingly, patients over 50 years old are more likely to feel increased fatigue. At T6, although some variables were slightly lower than those measured at T3, they remained higher than those observed at T0.Our results demonstrate that patients with HER2-positive breast cancer undergoing adjuvant trastuzumab tolerated the exercise training well, without side-effects. Furthermore, this supervised exercise program is an effective strategy to limit the cardiac toxicity of trastuzumab. Moreover, training improves cardiorespiratory and metabolic capacity during exercise (maximum and sub maximal), reduces fatigue and pain, and ultimately improves the quality of life of breast cancer patients. These beneficial effects were prolonged 3 months after the intervention. Tailored training may therefore provide additional benefits on top of the usual cancer treatment and prevent exacerbations of physiological toxicities that occur as a result of treatment
Fournié, Claire. "Activité physique adaptée et cohérence cardiaque en soins de support : leurs effets sur la variabilité de la fréquence cardiaque et la qualité de vie en post-traitement d’une hémopathie maligne." Thesis, La Réunion, 2020. http://www.theses.fr/2020LARE0009.
Повний текст джерелаIntroduction: Hematologic malignancies require aggressive treatment, including intensivechemotherapy and sometimes hematopoietic stem cell transplantation. The repercussions of cancer and its treatment is recognized for their significant long-term adverse effects on health-related quality of life. As a part of cancer treatment, physical exercise is known to improve mainly physical functioning and fatigue, but there are still questions regarding its impact on psychological and emotional functioning. Nonetheless, heart rate variability biofeedback (HRVB) is recognized for its positive effects on autonomic nervous system balance and emotional self-regulation. Recent research in neurocardiology has shown the benefits of Cardiac Coherence (CC) training on the autonomic balance and the psycho-emotional state. Method: The objectives of the research undertaken in this thesis are to evaluate the effects of a nonpharmacological intervention on quality of life in adult hematologic patients in post-treatment time. The recovery of physiological balance is indexed by the Heart Rate Variability (HRV), which is recognized as a window of the Autonomic Nervous System (ANS). We present four studies: an experimental study in healthy subjects to better understand the mechanisms of HRV during slow and deep breathing; a feasibility study on the implementation of an APA program in hematology; preliminary results of a randomized controlled trial evaluating the effects of a program associating APA and CC on HRV, quality of life, fatigue and anxiety-depression; and a qualitative study evaluating the program’s implementation and the effects of the both interventions. Results: Our results first show the feasibility of APA and CC in these patients. Although the results of the HRV analysis are inconclusive, they tend to confirm that CC intervention results in stimulation of vagal tone. Qualitative evaluation provides us with many important insights into the appropriateness of the interventions to the specific needs of the patients and their effectiveness in optimizing a return to the active daily life. Discussion: This research provides new experimental evidence in understanding the mechanisms of cardiac coherence and its applications in the clinical setting. Further experimentation is still needed to deepen our knowledge in the context of a psychophysiological approach in APA on cancer
Engle, Susan. "Acupuncture holds promise as supportive care in cancer treatment." 2008. http://www.ocomlibrary.org/images/PDF/studentpapers/susanengle.pdf.
Повний текст джерелаKlafke, Nadja. "Interpersonal factors impacting the decision to (continue to) use complementary and alternative medicine (CAM) in men with cancer: a mixed-methods study." Thesis, 2014. http://hdl.handle.net/2440/97249.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Psychology, 2014
Edwards, Zoe, Alison Blenkinsopp, Lucy Ziegler, and M. Bennett. "Cancer patients’ views on community pharmacy pain medicines consultations in advanced cancer." 2016. http://hdl.handle.net/10454/8346.
Повний текст джерелаEvery year in England and Wales, 105,000 people sufferfrom uncontrolled cancer pain and are rarely offered community pharmacy medicine consultations (e.g. Medicines Use Reviews -MURs)[1]. Our aim was to examine how patients with cancer pain deal with their pain medication and to investigate their experiences of and attitudes towards community pharmacy.
Beauchemin, Melissa Parsons. "Supporting Clinical Decision Making in Cancer Care Delivery." Thesis, 2019. https://doi.org/10.7916/d8-70wy-w603.
Повний текст джерелаHuang, Szu-Ting, and 黃詩婷. "The Effectiveness of Supportive Psychotherapy for Children of Parents With Cancer." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/38389466856224672882.
Повний текст джерела臺北醫學大學
護理學研究所
98
The major purpose of this study was explored the effectiveness of supportive psychotherapy for children of parents with cancer. The research design was to adopt experimental method and randomized controlled trial. The subjects were children of parents with cancer (aged 10~24) recruited from a local teaching hospital Oncology department in Taipei City. The subjects separated for experimental group (group A) and control group (group B) randomly. Control group only received general medical care. Experimental group not only received general medical care but also supportive psychotherapy which included supportive group and nursing health consultation two parts. The supportive group was leading by psychiatric registered professional nurse and counseling psychologist as group therapist and collaborative therapist in around 90 minutes each week for six weeks. Nursing health consultation group used telephone interviews and guided by health education sheet to concern the experimental group adapted to parent diseased process, emotional distress, parent-children relationship… etc. The research instruments used included the Children’s Depression Inventory, Beck Anxiety Inventory, Chinese version of the Positive and Negative Suicidal Ideation, Parents and Children Relationship Scale and Spirituality Assessment Scale. Statistical analysis used descriptive and inferential statistics and effectiveness analysis used Repeated Measures ANCOVA. Other group issues were discussed by qualitative analysis. Statistical results found experimental group improved obviously in depressive symptoms, negative suicidal ideation, parents-children relationship and spirituality health than in control group. Supportive group issues analysis categories were ambiguous cancer, transform of growth, seeking support strength and hope for future. The results showed supportive psychotherapy could ameliorate children of parents with cancer’s emotional distress effectively, reinforce perception of parents-children relationship and advance the power of inside support. These results will help clinical nurses use supportive psychotherapy to improve children of parents with cancer’s psychological adaption.
Liu, Li-Ni, and 劉莉妮. "The Effectiveness of a Continuing Supportive Caring Model for Breast Cancer Women." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/90444184911258511160.
Повний текст джерела輔仁大學
護理學系碩士班
91
The aim of this study was to investigate the effectiveness of a continuing supportive caring model on social support and disease uncertainty for breast cancer women. Quasi-experimental research design was used in this study. Patients were selected by purposive sampling from two surgical clinics of two teaching hospitals in Taipei. The eligible women were assigned to either control or experimental group based on the different time interval. The control group received standard care and the experimental group received standard care plus interventions based on a continuing supportive caring model. Participants completed questionnaires at three time points: baseline between two weeks after diagnosis, one month post-operation, and three months after diagnosis. The questionnaire included demographic data, social support scale, and disease uncertainty scale. A total of 61newly diagnosed breast cancer women were recruited in this study, including 31 women of the experimental group and 30 women of the control group. After three months of diagnosis, 56 women accomplished the follow-up including 27 women in the experimental group and 29 women in the control group. The results were analyzed using SPSS 10.0 software. The results of this study showed: (1) The social support of the experimental group increased significantly at one month following baseline and then kept in flat, but the control group decreased significantly at one month following baseline and then kept in flat. Both groups showed significant changes on three time points on social support;(2) The disease uncertainty of the experimental group decreased significantly at one month following baseline and then decreased, but the control group kept in flat first and then decreased significantly. Both groups showed significant changes on three time points on disease uncertainty;(3) In the experimental group, social support and disease uncertainty improved significantly than the control group on one month post-operation and three months post-diagnosis. The results of this study may help clinical nurses and hospital managers in care of newly diagnosed breast cancer women, and may contribute to improving the quality of breast cancer patients’ care in Taiwan.
Lu, Xiao Mei. "Primary and secondary prevention of cancer using the supportive-educative role of the oncology nurse." Thesis, 2010. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000641.
Повний текст джерелаCervical cancer, breast cancer and Kaposi's sarcoma are the three most common cancers in women in sub-Saharan Africa. The health care providers in developing countries regularly encounter women with advanced, incurable cervical cancer. Cervical cancer can however, be prevented, even among women at high risk for the disease, through screening using relatively simple technologies. The purpose of the study was to determine whether the supportive-educative role of the oncology nurse can contribute to the prevention of primary and secondary cervical cancer, breast cancer and Kaposi's sarcoma in women living in Soshanguve, South Africa.
Wu, Jung-Ju, and 吳蓉茹. "The radiosensitizing effect of Chinese herbal medicines in cultured breast cancer cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/95912705581212401459.
Повний текст джерела中國醫藥大學
中國醫學研究所
93
The incidence and mortality of breast cancer in Taiwan are increasing year by year. Breast conserving therapy including conserved mastectomy combined with radiation therapy is the contemporary choice of treatment. Radiosensitizers are often used in radiation therapy program to augment the anti-tumor effect. However, the clinical application of traditional radiosensitizers is limited due to their serious side effects. In this thesis, the radiosensitizing effect of Chinese herbal medicines in cultured breast cancer cells was examined to search for new radiosensitizers with high therapeutic effects but low side effects. First, the effects of 20 Chinese herbal medicines within the categories of clearing away heat and detoxication as well as promoting circulation and dispelling stagnant blood (such as Artemisia apiacea, Taraxacum mangolicum, Patrinia scabiosaefolia, Viola yedoensis, Hedyotis diffusae, Lonicera japonica, Paeonia suffruticosa, Polygonum cuspidatum, Isatis indigotica, Scutellaria baicalensis, Phellodendron amurense, Savia tatarica, Carthamus tinctorius, Sparganium stoloniferum, Curcuma zedoaria, Panxa pseudo-ginseng var.notoginseng, Curcuma longa, Vaccaria pyramidata、Glycyrrhiza uralensis, and Prunella vulgaris) on cell growth of MDA-MB-231 (p53-, Rb-, ER-) human breast cancer cells were examined. The components of some herbal medicines, such as Epigallocatechin gallate, baicalin, and baicalein, were also examined. Roscovitine, a known radiosensitizer in MDA-MB-231 cells, was used as a positive control. The growth inhibition induced by herbal medicines was measured by MTS assay. Some herbal medicines, such as Curcuma longa, Sparganium stoloniferum, Taraxacum mangolicum, and Isatis indigotica, showed no significant growth inhibition in MDA-MB-231 cells (P>0.05). Some herbal medicine and their components, such as Scutellaria baicalensis, Phellodendron amurense, Vaccaria pyramidata, baicalin, and baicalein, induced significant growth inhibition in a dose-dependent manner in MDA-MB-231 cells (P<0.05). The 50% inhibitory concentrations (IC50s) of roscovitine, baicalin, baicalein, Phellodendron amurense, Vaccaria pyramidata, and Scutellaria baicalensis were 10.3, 13.8, 26.0, 32.3, 36.9 and 207.7 μg/ml, respectively. On the contrary, most of the herbal medicines demonstrated no significant growth inhibition in MCF-7 (p53+, Rb+, ER+) human breast cancer cells by MTS assay, except Phellodendron amurense. Using MTS assay, these is no significant radiation–induced growth inhibition observed in both MDA-MB-231 and MCF-7cells 24、48、72、96 hours after 3~7 Gy irradiation. In contrast, radiation (2、3、4、5 Gy) exhibited significant dose-related growth inhibition in MDA-MB-231 cells by clonogenic survival assay. The growth inhibition rates of 2, 3, 4, and 5 Gy were 26%, 39%, 54%, and 65%, respectively, as compared with negative control. The radiosensitizing effects of herbal medicines in MDA-MB-231 cells were examined by clonogenic survival assay. Some herbal medicines, such as Scutellaria baicalensis, Curcuma zedoaria, Hedyotis diffusae, Phellodendron amurense, Sparganium stoloniferum, Baicalin, and Baicalein, showed significant enhancement of radiation-induced growth inhibition as compared to radiation alone. Compared with radiation (3 Gy) alone, the enhanced growth inhibition rates for radiation in the presence of 5.0 μM Roscovitine, 12.5 μg/ml Scutellaria baicalensis, 25 μg/ml Scutellaria baicalensis, 500 μg/ml Curcuma zedoaria, 250 μg/ml Hedyotis diffusae, 500 μg/ml Hedyotis diffusae, 6 μg/ml Phellodendron amurense, 12.5 μg/ml Phellodendron amurense, 18 μg/ml Phellodendron amurense, 25 μg/ml Phellodendron amurense, 6.25 μg/ml Baicalin, 12.5 μg/ml baicalin, 3 μg/ml Baicalein, or 6.25 μg/ml Baicalein, were 26.8%, 19.5%, 59.3%, 32.9%, 41.5%, 47.4%, 27.7%, 54.5%, 57.0%, 74.9%, 49.0%, 71.8%, 32.0% and 55.4%, respectively (p<0.05)。 Furthermore, the molecular basis for the enhanced growth inhibition of MDA-MB-231 breast cancers by a combination of radiation and herbal medicines was examined. The effects of radiation and herbal medicines on the cell cycle were examined by flow cytometric analysis. There was a significant increase in the accumulation of cells at the G2-M phase of the cell cycle after 5 Gy irradiation exposure. Scutellaria baicalensis and Phellodendron amurense combined with radiation (4 Gy) showed no significantly increase in Sub G1 and G2-M phase, compared with radiation alone. Moreover, radiation induced a 3~4 fold increase in micronuclei formation (a marker of chromosome damage) in MDA-MB-231 cells. Scutellaria baicalensis and Phellodendron amurense combined with radiation (4 Gy) showed no significantly increase in micronuclei formation, compared with radiation alone. In conclusion, Scutellaria baicalensis、Phellodendron amurense、Vaccaria pyramidata showed significant radiosensitizing effect on MDA-MB-231 breast cancer cells, suggesting their potential for the development of novel radiosensitizers. Further study is needed to understand the underlying mechanisms.
Secombe, Kate Rebecca. "Exploration of the gut microbiome as a predictive factor for cancer treatment-induced gastrointestinal toxicity." Thesis, 2021. https://hdl.handle.net/2440/134012.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Biomedicine, 2021
Pearce, Nancy Jane Mae. "Older Adults Living with Cancer: Supportive Care Needs and Utilization of Peer Support Services." Thesis, 2007. http://hdl.handle.net/10012/3168.
Повний текст джерелаWu, Chang-Che, and 巫昌哲. "Fabrication of ZnO Paper by Co-Deposition of ZnO Nanoparticles and Anti-Cancer Medicines." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/36936471637217710850.
Повний текст джерела國立暨南國際大學
電機工程學系
103
Deposition of ZnO nanoparticles or nanoclusters on paper substrate (so called ZnO paper) has been confirmed to be useful as a platform for anti-bacterial testing. Since paper substrate in nontoxic and biodegradable, ZnO paper is quite suitable for being used in the biomedical area. Therefore, the purpose of this work is to expand the applications of ZnO paper in the area of biomedical teting. In this thesis, we try to incorporate anticancer drugs into the solution for the zinc oxide nanoparticles growth such that anti-cancer drugs can be co-deposited onto the paper substrate simultaneously while depositing the zinc oxide nanopartilcles. As a result, anti-cancer drugs-containing ZnO paper will be obtained. In this work, the zinc oxide nanoparticles were obtained by using chemical reduction form the zinc acetate acide. Two anti-cancer drugs, Iressa and Staurosporine, were selected for the co-deposition with zinc oxide nanoparticles on cellulose paper. In order to confirm that the anti-cancer drugs do have been deposited onto the paper substrate, we used scanning electron microscope (SEM) for the surface morphology check making sure that the ZnO nanoparticles as well as anti-cancer drugs were deposited onto the cellulose paper. Enenery-Dispersive X-ray Sepectroscopy (EDX) and Fourier Transformed Infrared Spectroscopy (FTIR) were then used to check the bondings and deposited amount of ZnO nanoparticles and anti-cancer drugs. UV light illumination during the fist 5 and 10 min of the co-deposition process is proposed to be in favor of the loading of anti-cancer drugs on the ZnO nanoparticles. In the work, we checked the effet of UV illumination on the anti-cancer drugs loading for the ZnO nanoparticles deposited for 30h, 50 h and 72 h, respectively. From our experimental results, it isfound that both the co-deposition time of the ZnO paper and the amount of water during co-deposition affect the bonding of the co-deposited ZnO and anti-cancer drugs. For co-deposition of 250M Iressa in 100ml water, it is observed that the C-Cl and C-F bonds icrease with increasing co-deposition time, while the N-H bonds do not affect much by the co-deposition time. However, after being subjected to UV illumination, the N-H bonds also increases as co-depositon time. If the amount of co-deposition water increases to 200 ml, the effect of UV illumination on the N-H bonding enhance is weakened further and not been able to increase even after UV illumination due to the solution is diluted. For co-deposition of 100nM Staurosporine in 1 ml water, it is found that the intensity of N-H bonds is almost independent of the co-deposition time, but inreases rapidly at a co-depositon time of 72 h after UV illumination. We clearly observed that the intensity of C-H bonds increases with the co-deposition time after UV illumination when the amount of Staurosporine is increased to 200 nM. In conclusion, we confirmed that the chemical reduction method is effective to co-deposit the ZnO nanoparticles and anti-cancer drugs onto the cellulose paper as long as the growth condition is correct.
Yeh, Chia Chi, and 葉家綺. "Symptom Distresses, Coping Strategies and Supportive Care Needs in Patients with Colorectal Cancer after Surgery." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/awnjye.
Повний текст джерелаAhwaliaAziza, Yulanticha Diaz, and 邱玲雅. "Psychological Distress and Unmet Supportive Care Needs of Parents as Caregiver of Children with Cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/wmstrz.
Повний текст джерела國立成功大學
護理學系
105
Background: Having children diagnosed with cancer is a stressful condition for parents, facing physical, psychosocial, and financial burdens in life. These problems parents face are frequently neglected by health care providers and people around them when in reality parents play a significant role in caregiving children with cancer. Purpose: To identify the top rank of unmet supportive care needs, the prevalence of psychological distress, and the correlation of unmet supportive care needs and psychological distress among parents of children with cancer in Indonesia. Methods: A cross-sectional study was conducted among 100 parents of children with cancer from pediatric ward of two public hospitals in Central and East Java, Indonesia. This study chose the Supportive Care Needs Survey for Partner and Caregiver (SCNS-P&C45) Indonesian version to measure unmet supportive care needs, and Hospital Anxiety Depression Scale (HADS) Indonesian version to assessed psychological distress including anxiety and depression. Results: Of the 100 parents surveyed, 83% had more than ten unmet needs, 49% encountered anxiety, and 25% had depression. The highest need for supportive care was information needs (66.68±23.07). Anxiety not only correlated with the total score of needs (p〈.001; r=.351) but also each domain of needs including informational, health care service, psychological, work, and social needs. Conclusion and recommendation: Most common needs among parents of children with cancer were informational needs. Anxiety is strongly correlated to unmet supportive care needs. We recommend health care providers to activate support groups to decrease parents’ anxiety and depression. There is also a necessity to increase parental education to fulfill their needs of information.
Zheng, Wei –Chang, and 鄭瑋昌. "Cytotoxicity Test of Cancer Cells by Using ZnO Paper Prepared with Co-Deposition of ZnO Nanoparticles and Anti-Cancer Medicines." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/51491426433738594776.
Повний текст джерела國立暨南國際大學
電機工程學系
103
This paper forcuses on the chemical co-deposition of anti-cancer drugs and zinc oxide nanoparticles (ZnO NPs) on paper substrate to form the ZnO paper containing anti-cancer drug. The anti-cancer drug-containing ZnO paper was then used as a test plateform for cytotoxicity test for cancer cells. We investigated the changes of the surface morphology as well as the bondings of the ZnO NPs and anti-cancer drugs co-dpoisted paper substrate as a function of various co-deposition times. By using the MTT assay (3- (4,5-cimethylthiazol-2- yl)- 2,5-diphenyl tetrazolium bromide assay) analysis, we checked the cell viability of normal and cancer cells cultivated on the anti-cancer drug-containing ZnO paper. The purpose of this is to help us understand whether the ZnO NPs is useful for enhancing the cytotoxicity to cancer cells. In addition, we would like to confirm if the co-dposition can simply load the anti-cancer drugs on ZnO NPs. In oder to confirm the anti-cancer drugs were properly loaded onto the ZnO NPs, the surface of the ZnO NPs and anti-cacer durgs co-deposited paper was observed by scanning electron microscope (SEM) and the bonding of which was detected by Fourier transform infrared spectroscopy (FTIR). Cell viability of cells cultivated on ZnO paper was analyzed by MTT assay in combining with enzyme-linked immunosorbent assay (Enzyme-linked immunosobent assay, ELISA). In this work, we also studied the cytotoxicity effect of direct contact and indirect contact of the ZnO NPs with the cells by placing the ZnO papers at different places in the culture plate. ZnO NPs deposited on the fiber structure of the paper substrate can be observed clearly by SEM, and changes over time of the bonding of the anti-cncer drugs co-deposited with ZnO NPs can be discerned from the FTIR peaks. These results confirm that the anti-cancer drugs can be successfully loaded onto ZnO NPs through the proposed chemical co-deposition method. We then applied the ZnO NPs and anti-cancer drugs co-deposited ZnO paper to the cytotoxicity test of cancer cells. By comparing with the ZnO paper without adding anti-cancer drugs, it is found that the anti-cancer drugs co-deposited ZnO paper does help in enhancing the cytotoxicity to the cancer cells, and the cytotoxicity effect of the ZnO paper contacted directly with the cancer cells is stronger than that contacted indirectly with the the cancer cells, though the difference is not obvious. placing the ZnO paper directly cotact with the cancer cells. In conclusion, our experimental results confirm that co-dposition of the anti-cancer drug and ZnO NPs can load the anti-cancer drug onto the ZnO NPs, and the resultant ZnO paper does enhance the apoptosis of cancer cells. The ZnO paper can be apparently used as a platform for cell cytotoxicity test and new anti-cancer drug development.
Edwards, Zoe, L. Ziegler, C. Craigs, Alison Blenkinsopp, and M. I. Bennett. "Pharmacist educational interventions for cancer pain management: a systematic review and meta-analysis." 2018. http://hdl.handle.net/10454/16804.
Повний текст джерелаEducational interventions by pharmacists for patients with cancer pain aim to improve pain management, but little is known about the different components of interventions and their effectiveness. Our aim was to assess the benefit of pharmacist delivered educational interventions for patients with cancer pain. A systematic review and meta‐analysis of experimental trials testing pharmacist delivered educational interventions for cancer pain was carried out to identify the components of interventions and effectiveness at improving pain‐related outcomes for patients with cancer. A literature review was conducted in EMBASE, MEDLINE, CINAHL, PsycINFO, ASSIA, Web of Science and CENTRAL from inception until January 2018 searching for educational interventions involving a pharmacist for patients with cancer pain. Four studies were included involving 944 patients. Meta‐analysis was carried out where possible. Meta‐analysis of three of the four studies found that mean pain intensity in the intervention group was reduced by 0.76 on a 0–10 scale (95% confidence interval), although only two of the studies used validated measures of pain. Improvements in knowledge, side effects and patient satisfaction were seen although with less reliable measures. Pharmacist educational interventions for patients with cancer pain have been found to show promise in reducing pain intensity. Studies were few and of varying quality. Further, good quality studies should be carried out in this area and these should be comprehensively reported. Trials measuring patient self‐efficacy and patient satisfaction are needed before the impact of the pharmacist delivered interventions on these outcomes can be established.