Дисертації з теми "Structural Insights"
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Gibson, Robert Patrick. "Structural insights into trehalose biosynthesis." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423843.
Повний текст джерелаTeo, Hsiang Ling. "Structural insights into ESCRT complexes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614102.
Повний текст джерелаBusam, Robert Durstberger. "Exonuclease I : structural and biochemical insights/." view abstract or download file of text, 2005. http://wwwlib.umi.com/cr/uoregon/fullcit?p3190508.
Повний текст джерелаTypescript. Includes vita and abstract. Includes bibliographical references (leaves 83-89). Also available for download via the World Wide Web; free to University of Oregon users.
McManus, Edward. "Structural insights into lipoate protein ligases." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614075.
Повний текст джерелаHunt, James. "Adhesion GPCRs : structural insights into receptor coupling." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590267.
Повний текст джерелаJames, Nathan Rhys. "Structural insights into noncanonical mechanisms of translation." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267783.
Повний текст джерелаCash, Jennifer N. "Structural and Biochemical Insights into Myostatin Regulation." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1313697112.
Повний текст джерелаSantiago, Cuéllar Julia. "Structural insights into ABA perception and signalling: structure of ABA receptor PYR1." Doctoral thesis, Universitat Politècnica de València, 2011. http://hdl.handle.net/10251/13260.
Повний текст джерелаSantiago Cuéllar, J. (2011). Structural insights into ABA perception and signalling: structure of ABA receptor PYR1 [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/13260
Palancia
Lau, Kelvin. "Binding and structural insights of the ryanodine receptor." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50503.
Повний текст джерелаMedicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
Velloso, Lucas Malard. "Structural insights into glycoprotein transport and viral escape /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-780-0/.
Повний текст джерелаWang, Sheng Verfasser], Oliver [Herausgeber] [Einsle, Roland [Sonstige] Schüle, Manfred [Sammler] Jung, Oliver [Akademischer Betreuer] Einsle, and Roland [Akademischer Betreuer] Schüle. "Structural insights into a novel histone methyltransferase - KMT9." Freiburg : Universität, 2019. http://d-nb.info/1224416538/34.
Повний текст джерелаLane-Serff, Harriet. "Structural insights into innate immunity against African trypanosomes." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:3a1415e6-3df4-42dd-827b-d05edb2137be.
Повний текст джерелаMorgan, Christopher Edward. "Structural and Mechanistic Insights into HIV Regulated Splicing." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1523011774871958.
Повний текст джерелаWang, Sheng [Verfasser], Oliver [Herausgeber] Einsle, Roland [Sonstige] Schüle, Manfred [Sammler] Jung, Oliver [Akademischer Betreuer] Einsle, and Roland [Akademischer Betreuer] Schüle. "Structural insights into a novel histone methyltransferase - KMT9." Freiburg : Universität, 2019. http://d-nb.info/1224416538/34.
Повний текст джерелаBohm, Raphael. "Structural Insights into Glycan Interactions of Human Pathogens." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/366018.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Science, Environment, Engineering and Technology
Full Text
Martínez, Llinàs Diana. "Structural insights into natural transformation and toxin-antitoxin systems." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/116311.
Повний текст джерелаThe incidence of gonococcal and pneumococcal infections remains high in developing countries and is increasing in many parts of the world. The need not only for treatment of the individual but also for control of the diseases at a community level is acute but the selection of appropriate treatments has become a complicated issue by the ability of Neisseria gonorrhoeae and Streptococcus pneumoniae to develop resistance to antibiotics. This PhD thesis investigates mechanisms related to horizontal gene transfer and growth arrest in N. gonorrhoeae and S. pneumoniae. The first part of the thesis is devoted to the study of natural transformation in N. gonorrhoeae and describes the procedures that have lead to the expression, purification and biochemical characterization of ComE, ComA and DprA, three proteins involved in the uptake and processing of environmental DNA. The second part of the thesis describes the structural characterization by X-ray crystallography of S. pneumoniae RelBE2, a chromosomally-encoded type II toxin-antitoxin system that has been linked to translation moderation and growth arrest under starvation conditions, and proposes a model for its regulation.
Jezyk, Mark R. Sondek John. "Structural insights into the regulation of PLC-[beta]2." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,511.
Повний текст джерелаTitle from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine. On title page "beta" appears as Greek character.
Liu, Qian. "Structural insights into apoptotic regulation by BCL-2 family." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95022.
Повний текст джерелаLa protéine MCL-1 (Myeloid cell leukemia 1), qui appartient à la classe de protéines anti-apoptotiques BCL-2, joue un rôle dans le maintien de l'intégrité mitochondriale durant l'apoptose. Les résultats obtenus par résonance magnétique nucléaire (RMN) et par titrage calorimétrique, nous ont permis de mettre en évidence la sélectivité de la protéine MCL-1 pour les ligands mammifères d'interêt biologiques qui contiennent le motif BH3 et nous avons ainsi démontré que le domaine central du facteur MCL-1 (cMCL-1) est nécessaire et suffisant pour cette interaction. Nous avons caractérisé in vitro l'interaction entre le domaine cMCL-1 et le facteur activé BID; cette interaction se produit lentement en solution mais est similaire à celle observée entre le domaine cMCL-1 et le peptide BID-BH3. De plus nous avons résolu la structure du complexe cMCL-1:BID-BH3, qui est une cible potentielle qui pourrait être à la base d'un criblage d'une banque de petites molécules dans le cas de tumeurs humaines malignes. BAK, une protéine pro-apoptotic modulaire, permet la perméabilité de la membrane externe de la mitochondrie: ce mécanisme est dénommé MOMP pour the mitochondrial outer membrane permeablization. Nous avons accompli l'étude structurale de la protéine BAK par cristallographie et diffraction de rayons X. Nous présentons deux complexes de la protéine BAK: un homodimère lié par une molécule de zinc (cBAK) et une qui contient un pont disulfure (cBAK-o). Le site de dimérisation se situe proche des résidu D160 et H164 pour cBAK et C166 pour cBAK-o, ce qui leur confère un élément de régulation unique pour moduler l'activité de BAK comme suggéré dans des essais d'activité mitochondriale. La protéine BAK est finement régulée grâce à son interaction protéine-protéine avec MCL-1. Nous avons caractérisé les changements conformations des facteurs BAK et MCL-1 à l'aide de détergents pour modéliser un environnement m
Chao, Mao-Hsun. "New insights into structural properties of incommensurate inclusion compounds." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274597.
Повний текст джерелаFriedmann, David R. "Thermodynamic and structural insights into CSL mediated transcription complexes." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267132072.
Повний текст джерелаByrne, Matthew James. "Structural insights into the biosynthesis of spirotetronate natural products." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687814.
Повний текст джерелаDent, Kyle Clayton. "Architecture and assembly of maize streak virus: insights from 3D electron microscopy." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13389.
Повний текст джерелаMaize streak virus (MSV), circular single stranded DNA (ssDNA) virus (~2.7kb), is the causative agent of Maize streak disease, and is a devastating pathogen that causes severe crop losses to subsistence farmers in sub-Saharan Africa. MSV is transmitted by the leafhopper Cicadulina mbila, and is the type member of the Mastrevirus genus (family Geminiviridae). MSV shares a unique twinned icosahedral ("geminate") virion architecture (22 x 38 nm) with all other family members. Geminate particles consist of 110 coat protein (CP) subunits that assemble onto a circular single-stranded DNA (ssDNA) genome. Each T= I unit is an incomplete icosahedron assembled from 55 CPs. The structures of MSV and African cassava mosaic virus (ACMV, genus Begomovirus) have been studied by electron cryo- microscopy (cryo-EM) previously. While these investigations revealed some details about the geminate architecture, the interactions of capsid components have not yet been adequately modelled. The two incomplete icosahedral "heads" of the geminate particle are offset from one another and apparently make distinct CP:CP contacts at this region of the virion. Information regarding the nature of quasi- equivalent CP conformers or the sets of amino acid residues that mediate these interactions has not been forthcoming. Since the experimental results of these previous studies are not available in a public database, we were motivated to revisit the structure of MSV in order to obtain a 3D experimental density that might aid pseudo-atomic modelling. The MSV CP:ssDNA interaction has also been shown to be crucial for systemic movement through the host. Hence, quasi-atomic modelling may inform development of antiviral strategies which aim to interfere with virion assembly. MSV virions were isolated from the leaves of maize plants infected by agro-inoculation and visualized in both heavy metal stain and vitreous ice after they had been adsorbed to a thin-layer of continuous carbon to prevent virion aggregation. Virus preparations consisted of distinct CP assemblies consisting of multiples of the incomplete T=I icosahedral unit. Monopartite (icosahedral), bipartite (geminate), tripartite, and higher assemblies were observed suggesting the MSV CP is not only multifunctional but also structurally versatile being able to package ssDNA of variable sizes. Low-dose images were recorded on film, and 3D reconstruction of both monopartite and bipartite capsid species carried out using standard single-particle image processing methodology. The resolution of the bipartite reconstructions was 26 A for the negative-stain dataset, and 23 A for cryo-EM dataset, while the resolution of the monopartite reconstruction was estimated to be ~15 A. Comparative modelling of the MSV CP was undertaken using the pentamer (CPs) of Satellite tobacco necrosis virus (STNV) as a structural template. Correlation-based fitting of icosahedral and geminate atomic models that varied in geometric arrangement of MSV CPs allowed the geometric parameters of the bipartite capsid to be determined. Fitting ofMSV CPs into the EM densities informed our understanding of interfaces which allow the CP to self-associate, and showed that CPs is in fact displaced within the icosahedral geometry of the heads by a 10° rotation about the 5-fold axes of symmetry in comparison to STNV; hence, while quaternary structure of the pentameric capsomer is conserved between these viruses, the quaternary interactions between capsomers of the T=I unit has diverged considerably. This study shows that the offset between the geminate heads of the MSV virion is ~-11°, and that this geometry appears to arise owing to a distinct set of CP:CP interfaces which occur across the equator between two quasi-icosahedral heads and involve regions that would interact to form the CPs: CPs interfaces within each of the heads (across 2-fold and 3-fold symmetry axes). Notably this offset differs from that reported for ACMV, which has a reported offset of 20°. Additionally, the resolution afforded by the icosahedral monopartite reconstruction provided the first structural evidence to suggest that the calcium ion binding site of the STNV CPs (located on the CS axis) is likely to be conserved in MSV. This result suggests that in common with other plant viruses, depletion of calcium ions may be required for genome egress in a newly infected host cell. This study highlights the importance of future high-resolution studies of this unique virion morphology by both X-ray crystallography and cryo-EM.
Bergen, Konrad [Verfasser]. "Structural insights into DNA polymerases encountering aberrant substrates / Konrad Bergen." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1078230455/34.
Повний текст джерелаKarathanassis, Dimitrios. "Structural insights into membrane binding by phox homology (PX) domains." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619724.
Повний текст джерелаSchäfer, Ingmar Bastian. "Structural insights into the function of the Varp/Vamp7 complex." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609037.
Повний текст джерелаHabenstein, Birgit. "Structural insights into fibrillar proteins from solid-state NMR spectroscopy." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10212.
Повний текст джерелаSolid-state NMR is the method of choice for studies on insoluble proteins and other high molecular weight protein complexes. The inherent insolubility of fibrillar proteins, as well as their complex architecture, makes the application of x-ray crystallography and solution state NMR difficult. Solid-state NMR is not limited by the molecular weight or by the absence of long-range structural order, and is thus a powerful tool for the 3D structural investigation of fibrillar proteins. The assignment of the NMR resonances is a prerequisite to obtain structural information at atomic level. The first part of this thesis describes the development of solid-state NMR methods to assign the resonances in large proteins. We apply these methods to assign the 33 kDa C-terminal domain of the Ure2p prion which is up to now the largest protein assigned by solid-state NMR. Our results provide the basis to study high molecular weight proteins at atomic level. This is demonstrated in the second part with the first high-resolution solid-state NMR study of Ure2 and Sup35 prion fibrils. We describe the conformation of the functional domains and prion domains in the full-length fibrils and in isolation. The third fibrillar protein addressed in this work is the Parkinson’s disease related α-synuclein whereof we demonstrate the NMR resonance assignment and the secondary structure determination of a new polymorph. Thus, the studies described here provide new insights in the structural diversity of fibril architectures, and plead to view fibrils as individuals from a structural point of view, rather than a homogenous protein family
Cowper, Ben. "Structural insights into host cell adhesion by Toxoplasma gondii MIC4." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9580.
Повний текст джерелаPolano, Maurizio. "Structural insights into alternate aggregation states of mouse prion protein." Doctoral thesis, SISSA, 2009. http://hdl.handle.net/20.500.11767/4765.
Повний текст джерелаGucinski, Ashley Christine. "Gas Phase Structural Studies of Peptide Fragment Ions: Structural Insights into Mass Spectrometry Fragmentation Mechanisms." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202766.
Повний текст джерелаSpivak, Mariano Alejo. "Electronic structure calculations on extended metal atom chains. Insights on structural, magnetic and transport properties." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/399580.
Повний текст джерелаEn este trabajo, se utilizaron diferentes métodos computacionales para estudiar las propiedades de cadenas extendidas de metales de transición (EMACs en inglés). Se simuló la flexibilidad estructural de cadenas de tres átomos de cromo, con CASSCF/CASPT2 y se identificaron estructuras simétricas y asimétricas en un entorno de baja energía. Basados en estos resultados, realizamos dinámicas moleculares de primeros principios (AIMD) para entender el efecto de la energía térmica y como ésta modifica la proporción de estructuras. También se estudiaron los enlaces metal-metal en compuestos de cromo, utilizando el modelo de orden de enlace efectivo (EBO) con los números de ocupación naturales de la función de onda CASSCF. Se calcularon constantes de acoplamiento magnético para compuestos bimetálicos y EMACs de níquel mediante dos estrategias. MC-PT2 con espacio activo mínimo utilizando orbitales moleculares mejorados a partir de un cálculo de estados-promediados, y se utilizó un método nuevo (MCPDFT) para el magnetismo de EMACs grandes, que ha mostrado buenos resultados en el compuesto de cinco níqueles. Finalmente, estudiamos propiedades del transporte de electrones para dos EMACs de rutenio. Proponemos el uso de un electrodo gate metálico para modular los niveles moleculares de los compuestos y obtener especies redox activas. También utilizamos un método químicamente más intuitivo, que propone crear pares iónicos dentro de la celda.
In this work we use different computational methods in the study of the properties of Extended Metal Atom Chains. The structural flexibility of trichromium chains has been simulated with CASSCF/CASPT2 and symmetric and asymmetric structures were identified in an extremely flat energy landscape. Based on these results, Ab initio molecular dynamic simulations were performed to understand how the thermal energy modifies the proportion of cited structures. In addition, the metal-metal bonding of chromium compounds was characterized using the Effective Bond Order (EBO) model with the natural occupation numbers of the CASSCF wave function. Furthermore, magnetic coupling constants were computed for nickel bimetallic and EMACs compounds, using two different approaches. Minimal active space MC-PT2 was performed with improved molecular orbitals based on state-average calculations, and a recently developed method (MCPDFT) used for the magnetism of large EMACs, showing good results in the five-nickel compound. Finally, the electron transport properties were simulated for two ruthenium EMACs. We propose the use of a metallic gate electrode to modulate the molecular levels of the compounds and achieve redox active species. In addition, another more chemically intuitive approach was tested, that consist of forming an ionic pair in-situ.
Mitchell, Carter Alexander. "Structural, functional, and computational insights into the ANL superfamily of enzymes." Thesis, State University of New York at Buffalo, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3598714.
Повний текст джерелаMembers of the ANL superfamily of enzymes are involved in primary and secondary metabolism throughout all domains of life and identify key pathways that contribute to essential physiological reactions as well as defense mechanisms to evade competition. Specifically, acetyl-CoA synthetases are directly involved in energy metabolism, while NonRibosoaml Peptide Synthetases and some Aryl-CoA Ligases produce secondary natural products that confer virulence for the producing organism. Due to the ANL superfamily's ubiquitous involvement in primary and secondary metabolism, gaining an understanding of how these enzymes work and identifying ways to regulate them could provide an alternative route for antibiotic targets. It is well documented that domain alternation is paramount for the ANL superfamily of enzymes including the adenylation and thioester-forming reactions of NRPS adenylation domains. This thesis utilizes structural and functional analysis in conjunction with computational methods to further our understanding of these unique enzymes.
In chapter 2 we present the structure of an adenylation:Peptidyl Carrier Protein di-omain NRPS from the cryptic PA1221 biosynthetic operon from Pseudomonas aeruginosa. The PA1221 structure is the second example of an adenylation:PCP in the PDB and validates the chimeric fusion interactions of EntE-B. The similar interacting regions are between the 2nd PCP helix and a helix in the N-terminal subdomain of the adenylation domain as well as the loop connecting the longest β-strands of the C-terminal subdomains interacting with loop 1 of the PCP.
Chapter 3 presents the structure of an acetoacetatyl-CoA Synthetase that is a confirmed substrate for a protein acetyltransferase, PatA, for inactivation through acetylation of the catalytic A10 lysine. This Streptomyces lividans acetoacetyl-CoA synthetase is the first structure to fully resolve the loop connecting C-terminal extension helix to the C-terminal subdomain. The C-terminal extension is only present in ACS proteins revealing an interaction where the C-terminal extension stabilizes the dynamic P-loop in the adenylate forming conformation.
In chapter 4 we further explore the PA1221 operon by functionally identifying the substrate preference of PA1215, the hypothetical fatty-acyl-CoA Ligase, that is proposed to acylate the charge PCP of PA1221. We computationally validate the substrate preference with a homology model and AutoDock to gain insight into the proteins slow kinetics. We also provide further insight into the biochemistry of a subset of ANL superfamily members, the phenylacetic acid CoA ligases, involved in the utilization of aryl-carboxylic acids as a carbon source as well as the derivatization of penicillin. We analyze their unique dimeric structures identifying structural motifs that are contributed through the dimeric interface, but are otherwise located to different sides of the enzyme in a monomeric form.
Finally, to help identify how the protein moves between the two productive conformations we subject members of the superfamily to computational dynamic simulations including Anisotropic Network Modeling, Interpolative Elastic Network Modeling, all-atom molecular dynamics, and analyze the output from these methods with Principal Component and Normal Mode Analysis. We developed a method to visualize a dynamic reaction coordinate through measuring the Conformation Determining Angle (defined by structural motifs that are present in superfamily members) and use this metric to interrogate all ANL superfamily member PDB entries for domain organization. Finally, we test our hypothesis that domain alternation proceeds through an extended, open conformation with structural comparisons and MD. Here we report functional and structural analysis of ANL superfamily members that are related through bacterial cell metabolism and natural product biosynthesis.
Charlton, Ian David. "New insights into micellar structural evolution and interaction using voltammetric methods." Thesis, University of Newcastle Upon Tyne, 1999. http://hdl.handle.net/10443/798.
Повний текст джерелаMacLellan, Jonathan G. "Structural insights into superbase chemistry and related inverse crown base systems." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275156.
Повний текст джерелаFlatt, Justin Wayne. "STRUCTURAL INSIGHTS INTO RECOGNITION OF ADENOVIRUS BY IMMUNOLOGIC AND SERUM FACTORS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1387451692.
Повний текст джерелаSui, Xuewu. "Structural and biochemical insights into catalytic mechanisms of carotenoid cleavage oxygenases." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1473258604663537.
Повний текст джерелаLeen, Eoin. "Structural insights into the transcription and translation of murine norovirus RNA." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11173.
Повний текст джерелаLougher, Matthew J. "Functional and structural insights into MmyJ, An ArsR-like transcriptional repressor." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77520/.
Повний текст джерелаVarzandeh, Simon. "Structural and biochemical insights into the ATP-dependent chromatin remodeler LSH." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29515.
Повний текст джерелаGiorgetti, Alejandro. "Structural predictions of HCN/CNG ion channels: Insights on channels' gating." Doctoral thesis, SISSA, 2004. http://hdl.handle.net/20.500.11767/4655.
Повний текст джерелаPaoletti, Francesca. "Structural and functional insights into the biological function of mouse proNGF." Doctoral thesis, SISSA, 2006. http://hdl.handle.net/20.500.11767/4829.
Повний текст джерелаLi, Lichun. "Insights into subgenomic RNA synthesis in coronaviruses from structural and biophysical studies." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2431.
Повний текст джерелаJackson, Pilgrim J. "Structural insights into appetite : investigations of the ligands involved in melanocortin signaling /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.
Повний текст джерелаVaradan, Ranjani. "NMR studies of polyubiquitin chains insights into structural basis of functional diversity /." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1959.
Повний текст джерелаThesis research directed by: Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Johnston, Christopher Alan Siderovski David P. "Structural insights into the molecular basis of heterotrimeric G-protein signal transduction." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1240.
Повний текст джерелаTitle from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Medicine (Pharmacology)." Discipline: Pharmacology; Department/School: Medicine.
Cole, David K. "Biophysical and structural insights into the mechanism of T cell surface recognition." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442837.
Повний текст джерелаCox, Georgina. "The FusB family of fusidic acid resistance proteins : structural and mechanistic insights." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581880.
Повний текст джерелаCiniawsky, Susanne. "Structural and functional insights into the mechanism of the Pex1/6 complex." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-183979.
Повний текст джерелаMelo, Arthur [Verfasser]. "Structural insights into the activation mechanism of the EHD family / Arthur Melo." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/115300805X/34.
Повний текст джерелаLa-Borde, Penelope Jane. "Activation of the vasopressin and oxytocin receptor family : structural and mechanistic insights." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7639/.
Повний текст джерелаPazicky, Samuel [Verfasser]. "Structural and functional insights into apicomplexan gliding and its regulation / Samuel Pazicky." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1226936415/34.
Повний текст джерела