Дисертації з теми "Stressful conditions"
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Khatchadourian, Armen. "Lipid droplets under stressful conditions." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116901.
Повний текст джерелаLes gouttelettes lipidiques (GL) sont des organites phylogénétiquement conservées et impliquées dans plusieurs fonctions cellulaires. Durant les deux dernières décennies, notre compréhension des rôles biologiques et physiologiques des GL a augmenté de manière draconienne. Plusieurs observations suggèrent fortement que les GL jouent un rôle important dans l'inflammation, ainsi que dans les désordres métaboliques tels que le diabète de type 2 (DT2). Malgré cette avancée, plusieurs aspects de la biologie des GL et de leurs rôles dans des maladies demeurent méconnus.Le centre des GL est riche en lipides neutres qui peuvent se mobiliser et servir comme source d'énergie. La couche phospholipidique entourant le centre de la GL est associée à plusieurs protéines et enzymes métaboliques. Bien que les GL puissent être induites par des acides gras, elles peuvent aussi l'être dans des conditions de stress. Par contre, les mécanismes de l'accumulation de GL par des conditions de stress ne sont pas encore bien compris. Notre objectif principal est de comprendre la régulation de la formation de GL par le stress oxydatif, l'inflammation et le stress métabolique. Premièrement, nous avons investigué les GL dans des cellules exposées à des stresseurs tels que des nanocrystaux métalliques et des dérivés réactifs d'oxygène. La formation de GL et l'expression de perilipin-2, qui est une protéine structurelle des GL, ont tous deux augmenté dans les cellules stressées. De plus, une supplémentation en antioxydant (n-acétylcystéine) ou un traitement avec un inhibiteur de p38 MAPK a réduit l'accumulation de GL causée par le stress. Ces observations suggèrent que le stress oxydatif et p38 MAPK jouent un rôle dans l'accumulation de GL dans des cellules stressées. Il est bien connu que les leucocytes et macrophages qui sont engagés dans l'inflammation contiennent une grande quantité de GL. Même si ce phénomène a bien été exploré dans les cellules immunitaires périphériques, il reste inexploré dans le système nerveux central (SNC). Ce faisant, nous avons investigué la dynamique et la régulation des GL dans les microglies, les cellules résidentes immunitaires dans le cerveau. Nous avons trouvé que dans les microglies stimulées avec les lipopolysaccharides (LPS), les GL et l'expression de perilipin-2 ont augmenté d'une manière dépendante de l'activation de l'Akt et p38 MAPK. Dans ces cellules activées, la phospholipase cytosolique A2-α (PLC A2-α), une enzyme fonctionnant dans la synthèse d'éicosanoides, des médiateurs lipidiques inflammatoires, colocalisait avec les GL. Ensemble, ces résultats indiquent que la formation de GL pourrait contribuer à la synthèse d'éicosanoides dans les microglies activées et servir de biomarqueurs d'inflammation dans le SNC.Pour mieux comprendre le rôle des GL dans la pathologie humaine, nous les avons examinées dans des tissues pancréatiques provenant de patients obèses ou diabétiques T2. Nos études immunohistochimiques ont révélé une augmentation de perilipin-2 dans les îlots de Langerhans chez les patients diabétiques obèses ou maigres, mais pas dans ceux de patients non-diabétiques. Ceci suggère que le DT2, mais non l'obésité, est requis pour une augmentation de perilipin-2 dans le pancréas. L'analyse d'expression de gènes par RT-PCR a confirmé l'augmentation de perilipin-2 observé antérieurement dans les îlots et a également révélé des altérations dans des gènes reliés aux fonctions des îlots, au métabolisme, et aux défenses anti-oxydantes. Ces changements, qui sont souvent associés à l'obésité et au DT2, constituent un mécanisme d'adaptation à la résistance à l'insuline et au stress métabolique.Pour résumer, nos études démontrent que l'accumulation de GL fait partie intégrante de l'adaptation des cellules au stress. Durant la prochaine décennie, le plus grand obstacle dans la recherche sur les GL sera de déterminer comment la composition lipidique ou protéinique de ces organites affecte leurs fonctions biologiques.
Brown, Tiffany Leigh. "Stressful life events and coping in college students." CSUSB ScholarWorks, 1994. https://scholarworks.lib.csusb.edu/etd-project/522.
Повний текст джерелаBarnes, Ryan D., and Buck A. Bradley. "HELP: Handheld Emergency Logistics Program for generating structured requests for resources in stressful conditions." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/43872.
Повний текст джерелаThe speed and efficacy with which front-line warfighters in stressful conditions can submit resource requests, such as a casualty evacuation, could mean the difference between life and death. Traditional methods to call for resources require training, are error-prone and can be sluggish. The Handheld Emergency Logistics Program (HELP) was developed by the authors of this thesis to assist both trained and untrained persons in requesting resources from supporting agencies. HELP was developed to prove the concept that off-the-shelf mobile technology can significantly improve the speed and efficacy of resource requests. This thesis aims to allow HELP to exploit built-in sensors in modern commercial off-the-shelf handheld smart devices and their computation and communication capability to reduce the chance of error, reduce the need to pull information from memory, reduce manual data entry, and provide multiple redundant modalities for performing the same action. Our findings indicate that with the assistance of HELP, users submitting resource requests committed half as many errors and completed the request in half the amount of time as compared to a control group using traditional methods. We recommend that the concept of using smart devices to call for resources be further developed into a program of record.
Aziz, Izaddin Ahmad. "Individual difference predictors of well-being among displaced persons who live under stressful conditions." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40398.
Повний текст джерелаKelly, Charlene N. "The diversity of arbuscular mycorrhizal fungi functional and ecological responses to stressful soil conditions /." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3374.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains vii, 57 p. : ill. Vita. Includes abstract. Includes bibliographical references.
Jaramillo, Torres Hugo Alexander. "Intestinal health and microbiota in salmonids : the impact of probiotics under potentially stressful conditions." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/9705.
Повний текст джерелаSamuels, Veneshley. "Investigation of mycobacterial cell wall genes and their requirement for survival in immune related stressful conditions." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32963.
Повний текст джерелаKarlsson, Krister. "Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition." Doctoral thesis, Uppsala University, Department of Neuroscience, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4130.
Повний текст джерелаThe purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.
SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. The enzyme activity was found to release the biologically active fragments SP(1-7) and SP(1-8) as major products. The purified enzymes were characterized with regard to their biochemical and kinetic properties. The typical SPE is neither inhibited by phosphoramidon nor captopril nor phenylmethanesulfonylflourid (PMSF). In comparison to other known proteases SPE differed in characteristics regarding substrate specificity, inhibition-profile, cleavage pattern, and other kinetic parameters. The technically very delicate approach of micro purification of SPE from the rat ventral tegemental area (VTA) (this is a very small tissue), turned out to be possible with the ÄKTA™-purifier system. Studies revealed a crucial role of SPE in a series of clinically important neuropathological conditions, such as opioid tolerance, and withdrawal (SPE, increased); and heat-stress (SPE, increased). These findings emerged from assessment of enzyme activity in hypothalamus, nucleus accumbens (NAc) periaqueductal gray (PAG), pituitary, striatum, substantia nigra (SN), VTA, spinal cord. Viewing the role of SPE in morphine tolerance, it was possible to note regional differences with a decrease in PAG, and striatum, whereas an increase was seen in SN, and VTA. After heat-stress treatment, SPE was raised in several regions (cerebral cortex, hippocampus, diencephalon, cerebellum, spinal cord), and the most precise observation of this was located to the hippocampus structure.
Karlsson, Krister. "Substance P endopeptidase : purification and characterization of enzyme activity and evaluation of its function during stressful condition /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4130.
Повний текст джерелаKlima, Kerry Lee Belvill. "Hidden, Supported, and Stressful: A Phenomenological Study of Midlevel Student Affairs Professionals' Entry-Level Experiences with a Mental Health Condition." Bowling Green State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1522882922205522.
Повний текст джерелаSmith, Daniel R. "Implicit personality and leadership in stressful and dangerous situations: a first step." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43693.
Повний текст джерелаSousa, Carla Daniela Mota de. "Functional feeds to tackle meagre (Argyrosomus regius) stress: physiological responses under chronic and acute stressful conditions." Master's thesis, 2020. https://hdl.handle.net/10216/132018.
Повний текст джерелаSousa, Carla Daniela Mota de. "Functional feeds to tackle meagre (Argyrosomus regius) stress: physiological responses under chronic and acute stressful conditions." Dissertação, 2020. https://hdl.handle.net/10216/132018.
Повний текст джерелаAlmeida, Luís Alexandre Aires de. "The impact of capital regulation on banks' cost and profit efficiency under stressful economic conditions : cross-country evidence." Master's thesis, 2014. http://hdl.handle.net/10400.14/17048.
Повний текст джерелаGautrin, Sophie. "Une étude sur le rôle modérateur des évènements stressants vécus lors de l’enfance sur la relation entre les conditions de l’organisation du travail et la détresse psychologique." Thèse, 2011. http://hdl.handle.net/1866/5284.
Повний текст джерелаThe main objective of this master thesis was to verify the moderating effects of stressful life events from childhood on the relation between the work organization’s conditions and the level of psychological distress lived by workers from the Service de Police de la Ville de Montréal (SPVM). As a secondary objective, this thesis determined the direct effect of work organization conditions on the level of psychological distress. To complete this study, data from an investigation of 410 SPVM workers was used. This thesis demonstrated a low level of distress in this population. Also, the completed multilevel analysis confirmed that psychological demands and social support from the superiors were associated at the level of psychological distress. In fact, psychological demands contribute to increase it and the social support from the superior decrease the level of psychological distress. In addition, our results indicate that distress is to be less pronounced among men, couples, life habits (physical activities and no tobacco use),no tensions with children, no tensions with the spouse and the personality trait sense of control. Finally, this thesis hasn’t found any moderating effects of the children’s stressful life events on the relation between the work organization’s conditions and the level of psychological distress. Moreover, the multilevel analyses haven’t demonstrated the direct effect of children’s stressful life events psychological on the level of psychological distress.
Hsu, Lung-Ying, and 許瓏瑩. "Tissue-specific expression of heat shock protein 70 produced in developing zebrafish (Danio rerio) under non-stressful condition." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/32480752985812299157.
Повний текст джерела國立臺灣海洋大學
生物科技研究所
92
ABSTRACT A high expression of heat shock protein 70 (HSP70) was found to arise in zebrafish (Danio rerio) at 72 to 84 hr after fertilization [36, 37]. The spontaneously expressed HSP70 was later shown to comprise predominantly heat shock cognate 70 (HSC70), HSP70 synthesized under nonstressful condition, and very low level of stress-induced HSP 70 [53]. Owing to the constitutive expression of hsp70/hsc70 mRNA in developing zebrafish, the spontaneous production of HSC/HSP 70 was thought to be regulated at translational level [37]. A parallel up- and down-regulation of HSC/HSP 70 and their cochaperone DJ-2 in 72 to 108-hr-old zebrafish was also observed [53]. The objective of this research was to study the correlation between HSC/HSP 70 and DJ-2 gene expression in various tissues of developing zebrafish at both the mRNA and the protein level. Tissue-specific expression of heat shock factors 1 & 2 (HSF 1&2) that trigger the transcription of hsp/hsc 70 was also examined. Whole mount in situ hybridization using a riboprobe targeting hsp/hsc 70 mRNA detected a wide distribution of hsp70 mRNA in the brain and somite regions of 36-hr-old embryos. In contrast, the probe specifically hybridized with stress-induced hsp 70 mRNA gave hybridization signals only around the lens of zebrafish at different stages. Hence, hsc70 mRNA was produced in most zebrafish tissues. In 60 to 108-hr-old zebrafish late embryos and larvae, hsc70 mRNA was clearly detectable in their brains and pectoral fins, while a low level of this mRNA was found in somites. Tissue-specific HSC70 expression not closely associated with its corresponding mRNA was detected by whole mount immunocytochemistry The synthesis of HSC70 was found in the hindbrains, eye regions and the body surfaces of somites of 36-hr-old embryos In addition to its presence in the eyes and pectoral fins, HSC70 appeared as spots in some epithelial tissues of head regions in 60 to 108-hr-old zebrafish. The major fraction of dj-2 mRNA and DJ-2 molecules were shown to colocalize with hsc70 mRNA and HSC70 in developing zebrafish, suggesting the interaction between HSC70 and DJ-2 for assisting protein folding during zebrafish development. The appearance of hsf1 and hsf2 mRNA with hsc70 mRNA was seldom correlated in 36-hr-old zebrafish, yet colocalization of these transcripts was frequently observed in more mature zebrafish.