Дисертації з теми "Stress response protein p66ShcA"
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Covington, Sean M. "The Stress Protein Response of Pimephales promelas to Copper." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500868/.
Повний текст джерелаGonçalves, Nuno M. "Insights into the rice response to abiotic stress:." Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/95814.
Повний текст джерелаN/A
Fogl, Claudia Liliane Fiona. "Structure and function of the cardiac stress response protein MS1." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9408.
Повний текст джерелаMalakasi, Panagiota. "The regulation of oxidative stress response by a conserved response regulator protein in yeast." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273360.
Повний текст джерелаJenkins, Mark 1979. "A role for the Drosophila eIF4E binding protein during stress response /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82256.
Повний текст джерелаThe Drosophila forkhead transcription factor dFOXO is a transcriptional activator of d4E-BP. There is a strong reduction of d4E-BP peptide in a dFOXO null background. dFOXO null flies are also sensitive to oxidative stress, and rescue of this sensitivity through ectopic expression of UAS-d4E-BP(wt) in a dFOXO null background suggests d4E-BP is a downstream mediator of dFOXO oxidative stress resistance.
Mahmood, Ahsan. "Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24399.
Повний текст джерелаHearne, Catherine Mary. "A study of the heat shock response of Bacillus subtilis." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334111.
Повний текст джерелаChalmers, Fiona. "Improving protein yield from mammalian cells by manipulation of stress response pathways." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7666/.
Повний текст джерелаMuthevhuli, Mpho. "Investigation of the role of AtNOGC1, a guanylyl cyclase protein in response to abiotic and biotic stress." University of the Western Cape, 2018. http://hdl.handle.net/11394/6763.
Повний текст джерелаAgricultural production is one of the most important sectors which provide food for the growing world population which is estimated to reach 9.7 billion by 2050, thus there is a need to produce more food. Climate change, on the other hand, is negatively affecting major global crops such as maize, sorghum, wheat and barley. Environmental factors such as salinity, drought, high temperatures and pathogens affect plant production by oxidatively damaging the physiological processes in plants, leading to plant death. Poor irrigation used to combat drought result in salinasation, which is estimated to affect 50% of arable land by 2050. Plants have developed several mechanisms that protect them against stress and these include overexpression of stress responsive genes and altered signal transduction to change the expression of stress responsive genes, among others. Cyclic 3’5’ guanosine monophosphate (cGMP), a second messenger that is synthesised by guanylyl cyclase (GC), transmit signals to various cellular functions in plants during plant development, growth and response to abiotic and biotic stresses. Arabidopsis thaliana nitric oxide guanylyl cyclase 1 (AtNOGC1) is a guanylyl cyclase which upon activation by nitric oxide (NO) leads to the production of more cGMP. Cyclic GMP further activates protein kinases, ion gated channels and phosphodiesterase which mediate response to various stresses. In this project the role of AtNOGC1 was investigated in response to abiotic and biotic stresses through analysis of its evolutionary relationships, promoter, gene expression and functional analysis via the viability assays in Escherichia coli (E.coli). Phylogenetic tree, exon-intron structure and conserved motifs were analysed using the Molecular Evolutionary Genetics Analysis (MEGA V.7), Gene Structure Display Server 2.0 (GSDS 2.0), and Multiple Expectation Maximisation for Motif Elicitation (MEME) tools respectively. AtNOGC1’s gene expression was analysed by the Real-Time Quantitative Reverse Transcription Polymerase Reaction (qRT-PCR), whereas functional analysis was carried out using the cell viability (liquid and spot) assays to determine its ability to confer stress tolerance to E. coli.
Nájar, Durán Elena. "Characterization of the maize protein ZmSTOP1 and its role in drought stress response." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/327875.
Повний текст джерелаWater deficit has become a very important threat to agricultural yield worldwide. The identification of new players in drought stress response among crop plants is vital to understand their adaptation to increasing environmental challenges. Abscisic acid (ABA) is a plant hormone known to mediate drought adaptative responses such as seed dormancy, stomatal closure and root growth arrest. In the case of stomatal regulation, ABA drives the activation of OST1 kinase, which phosphorylates different substrates, for example NADPH oxidases, ionic channels and transcription factors, which will finally lead to stomatal closure. Although stomatal closure in response to ABA is essential to avoid desiccation, and thus, the death of the plant, a certain level of stomatal conductivity must be maintained to permit gas exchange and transpiration, essential to drive water and solutes uptake through the roots. We identified and characterized a new maize C2H2 zinc-finger putative transcription factor that presents homology to the Arabidopsis Sensitive to Proton Rhizotoxicity (STOP)1, which is critical for aluminum and proton tolerance in acidic soils. We determined that ZmSTOP1 is a well-conserved protein between plant species, especially in its four zinc-finger domains, which are characteristic of the STOP1-like proteins in plants. ZmSTOP1 is one of a five-members family of STOP1-like proteins in maize. It localizes in the nucleus, and has the ability to bind DNA, though no specific DNA targets were identified. In this work we show how ZmSTOP1 can complement AtSTOP1 phenotype in low pH conditions. Moreover, we detected that ZmSTOP1 overexpression promotes a differential response to ABA in roots and shoots. Root growth is over-inhibited whereas stomata present insensitivity to the ABA signal, remaining more open than the wild type after ABA treatment. Through microarray analyses we determine that the genes affected by ZmSTOP1 are classified mainly in signaling, regulation of transcription and stress. Its overexpression promotes changes in the expression pattern of several genes that are important for ionic homeostasis and signaling in cells, like the potassium channel KT2/3, the calcium transporter CAX7, the NADPH oxidase RBOHD, or the plasma membrane proton pump ATPase HA2, and it can induce ectopic expression of these genes in roots or shoots. The deregulation of these genes can affect the global behavior of the plant before drought stress conditions, as ABA effects depend deeply on ionic homeostasis, and could represent a possible explanation for the phenotypes observed. Additionally, we established that this protein is an interactor and a substrate of OST1 kinase. The phosphorylation by this kinase modulates ZmSTOP1 effect on stomatal regulation. In summary, by characterizing ZmSTOP1 protein we have shed light into the complex network regulating drought tolerance in a crucial plant for human and animal consumption like maize. These results can be important for focusing further genetic improvement of the plant, by either genetic engineering or classic breeding.
Liu, Fenglong. "Calcium-dependent protein kinase regulates soybean serine acetyltransferase in response to oxidative stress." [Gainesville, Fla.]: University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE0000561.
Повний текст джерелаToman, Ondřej. "Stress response in Bacillus subtilis : signalization, adaptation and the role of protein L24." Paris 11, 2006. http://www.theses.fr/2006PA112175.
Повний текст джерелаManza, Linda Lee. "Characterization of Protein Sumoylation in Response to Alkylation Stress in HEK 293 Cells." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193944.
Повний текст джерелаMutavchiev, Delyan Rumenov. "Regulation of fission yeast cell polarity by stress-response pathways." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29006.
Повний текст джерелаNaim, Adnan. "The Role of G3BPs in the Stress Response Pathway." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367499.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Willis, William L. "YB-1 Stress-Response Protein Conformation Implicated in Post-transcriptional Control of Myofibroblast Differentiation." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376593223.
Повний текст джерелаDuRose, Jenny Bratlien. "The unfolded protein response integrating stress signals from the endoplasmic reticulum to the nucleolus /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3330123.
Повний текст джерелаTitle from first page of PDF file (viewed November 13, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
DeAngelis, Cara Marie. "Characterization of the Vibrio cholerae Phage Shock Protein Response." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556723496251854.
Повний текст джерелаSama, Reddy Ranjith Kumar. "FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/704.
Повний текст джерелаBrickman, Todd. "The Heat Shock Protein 70 Response to Acute and Endurance Exercise." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1177608338.
Повний текст джерелаArensdorf, Angela Marie. "The Mechanisms and Consequences of Gene Suppression During the Unfolded Protein Response." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4816.
Повний текст джерелаSaul-McBeth, Jessica. "Characterization of SipA, A Protein Important for Stress Responses in Vibrio cholerae." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1544540466901883.
Повний текст джерелаLam, Dennis, and 林勁行. "A study of biological role of reactive oxygen species in cellular response in stress." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869604.
Повний текст джерелаpublished_or_final_version
Biochemistry
Doctoral
Doctor of Philosophy
Li, Yimin. "Redox control of the transcriptional response to oxidative stress by Arabidopsis redox-sensitive basic leucine zipper protein 68." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/324.
Повний текст джерелаLiu, Jia, and 劉佳. "Role of FBXO31 in regulating MAPK-mediated genotoxic stress response and cancer cell survival." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205657.
Повний текст джерелаpublished_or_final_version
Anatomy
Doctoral
Doctor of Philosophy
Gammash, Mohammed Matuq. "Novel roles of the circadian clock protein neuronal PAS domain protein 2 (NPAS2) in the response to oxidative and heat stress." Thesis, Bangor University, 2017. https://research.bangor.ac.uk/portal/en/theses/novel-roles-of-the-circadian-clock-protein-neuronal-pas-domain-protein-2-npas2-in-the-response-to-oxidative-andheat-stress(a5d513b0-84c5-486e-add9-afea7eeed9e2).html.
Повний текст джерелаGeary, Bethany. "Determining the rates of protein synthesis in the zebrafish heart in response to chronic unpredictable stress." Thesis, University of the Highlands and Islands, 2016. https://pure.uhi.ac.uk/portal/en/studentthesis/determining-the-rates-of-protein-synthesis-in-the-zebrafish-heart-in-response-to-chronic-unpredictable-stress(0b49f21e-543c-4ba9-a24d-496ade328b0b).html.
Повний текст джерелаOmikorede, Omotola. "The role of ER stress and the unfolded protein response in obesity associated type 2 diabetes." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/10182.
Повний текст джерелаKershaw, Rachael Maria. "Delayed response of the CYS326 variant of the DNA repair protein OGG1 to cellular oxidative stress." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3035/.
Повний текст джерелаDavies, Matthew. "Investigation of the unfolded protein response and other stress-related responses in distinct models of neurodegeneration." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/390653/.
Повний текст джерелаKarreman, Robert Jan. "The localization, function and applications of the stress response protein Hsp12p in the yeast Saccharomyces cerevisiae." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/4278.
Повний текст джерелаIncludes bibliographical references (leaves 117-132).
Since 1990, the yeast Saccharomyces cerevisiae small heat shock protein Hsp12p, has continuously appeared in data associated with stress responses in this organism. Hsp12p is expressed abundantly in response to a large variety of different stresses, but for many years has eluded researchers as to its function, primarily because the viability of yeast strains lacking HSP12 are unaffected by osmotic stress and heat shock. Subsequent studies indicated that Hsp12p played a role in the adaptation of the cell wall of Saccharomyces cerevisiae to conditions of stress. However, the exact in vivo localization, specific function and mediation of function of Hsp12p had yet to be elucidated. The localization of Hsp12p was determined by fusion to the green fluorescent reporter protein, Gfp2p and a combination of epifluorescent microscopy and confocal imagery. Chemical extraction revealed that Hsp12p was present in the cell wall while fluorescent imagery was not conclusive. This fluorescent Hsp12p construct was later employed in a novel application to sense the stress status of yeast, which bears future promise for use in an industrial setting.
Dyer, Scott Douglas. "Evaluation of the efficacy of the stress protein response as a biochemical water quality biomonitoring method." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798352/.
Повний текст джерелаChew, Yee Lian. "Protein with Tau-like repeats (PTL-1) modulates the oxidative stress response, neuronal ageing and lifespan." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12497.
Повний текст джерелаScuto, Maria Concetta. "Mitochondrial biogenesis, protein misfolding and cellular stress response in aging and in neurodegenerative disorders: proteomic approach." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4055.
Повний текст джерелаPuddu, F. "Functional Analysis of the Cell Cycle Protein Dpb11 in Response to DNA Damage and Replicative Stress." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/158404.
Повний текст джерелаTan, Shixiong Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Cellular mechanisms affecting redox homeostasis in response to stress in Saccharomyces cerevisiae." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44627.
Повний текст джерелаBudi, Bunarta Hendra (Akin), and akin budi@rmit edu au. "On the effects of external stresses on protein conformation." RMIT University. School of Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20061116.123431.
Повний текст джерелаGross, Rosalyn. "Relationship of anger trait and anger expression to c-reactive protein in post-menopausal women." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002644.
Повний текст джерелаBouvier, Nicolas. "Conséquences rénales de l’activation de la réponse UPR (Unfolded protein response) par des stress toxique et ischémique." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P626/document.
Повний текст джерелаNative and grafted kidneys are stressed by multiple specific or non-specific insults leading to progressive structural deterioration. Responses to these insults are adaptive and preserve cell survival but may also promote inflammation, fibrosis and apoptosis. The most important of these adaptive pathways are HIF1α pathway, mTOR pathway, autophagy, unfolded protein response (UPR). The consequences of the UPR in kidney injuries are not well known. The objective of this study is to delineate the mechanisms and consequences of the activation of the UPR in response to toxic (cyclosporine) and ischemic (glucose starvation) stresses in two distinct cellular models (arterial endothelial cells and renal tubular cells). Here, we showed that UPR was engaged in cyclosporine-induced endothelial phenotypic changes, glucose starvation-induced inflammatory and angiogenic responses: NF-κB regulation by Ire1; distinct VEGF, bFGF and angiogenin regulation by Perk and Ire1. UPR is subtly modulated since its transducers do not induce identical processes. In conclusion these comprehensive works, we demonstrate the UPR is implicated in stress-induced adaptive pathways with different downstream responses according to the effector. Renal tissue degradation could be prevented by discovering and validating early biomarker and UPR modulators
Bouvier, Nicolas. "Conséquences rénales de l'activation de la réponse UPR (Unfolded protein response) par des stress toxique et ischémique." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00793364.
Повний текст джерелаIsa, Suleiman. "The impact of natural and synthetic PPARγ ligands on endoplasmic reticulum stress and the unfolded protein response". Thesis, Cardiff Metropolitan University, 2012. http://hdl.handle.net/10369/3294.
Повний текст джерелаDo, Minh-Ha T. "Stress, mixed messages, and hormone signaling regulation of translation and the unfolded protein response in pituitary gonadotropes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3307121.
Повний текст джерелаTitle from first page of PDF file (viewed July 1, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 166-176).
Diedrichs, Danilo Roberto. "A mathematical model of the unfolded protein response to stress in the endoplasmic reticulum of mammalian cells." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3284.
Повний текст джерелаGarland, Michael A. "Multi-stress proteomics: The global protein response to multiple environmental stressors in the porcelain crab Petrolisthes cinctipes." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1441.
Повний текст джерелаFALETTI, STEFANIA. "LSD1-DIRECTED THERAPY HINDERS GLIOBLASTOMA BY DEREGULATING ATF4-DEPENDENT INTEGRATED STRESS RESPONSE." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/789247.
Повний текст джерелаSommerweiß, Dietlind. "Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response". Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172386.
Повний текст джерелаFrigerio, Sara. "Plant response to abiotic stress : analysis of changes in the photosynthetic apparatus at both gene and protein level." Aix-Marseille 2, 2008. http://www.theses.fr/2008AIX22076.
Повний текст джерелаDans la première partie du travail, il a été analysé le comportement des différents subunités appartenantes à la famille multigénique du Lhcb, dans réponse à des différentes conditions de croissance en maïs (Zea mays). La redondance de ces séquences, en effet, a suggéré un possible rôle spécifique de chaque produit génique dans la capture de la lumière et dans la photoprotection, sur la base des conditions environnementales. Les plantes ont été poussées en différentes conditions de lumière et température, pour ensuite en isoler les tylacoides au fin de les tester pour l’accumulation des protéines des antennes (Lhc). Des significatives différences ont été relevées dans les antennes, soit majeurs (LHCII) que mineurs, du Photosystème II (PSII) et, en détail, la température a joué un important rôle, puisque le rapport LHCII/antennes mineures a montré une augmentation avec la diminution de la température. Le froid, en effet, est un facteur de stress assez puissant, dès qu’il réduit énormément la vitesse de transport des électrons au niveau de l’oxydation du QH2 de la part du Cytb6f, en déterminant un excès de réduction du plastoquinone. Dans la deuxième partie de cette thèse, la régulation par les conditions environnementales des polypeptides qui constituent l'antenne photosynthétique a été analysée en employant un mutant d’orge (Hordeum vulgare), viridis zb63, qui manque du Photosystème I, ce qui produit la réduction du plastoquinone et mime une surexcitation chronique du Photosystème II. [. . . ]
Mohd, Sukri Nursyuhada. "Influence of hyperthermia and antioxidant supplementation on redox balance and heat shock protein response to exercise." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.767577.
Повний текст джерелаRoode, Enrico Carlo. "The effect of exogenous DIM on Brassica napus and its role in response to heavy metal stress." University of the Western Cape, 2017. http://hdl.handle.net/11394/6242.
Повний текст джерелаBrassica napus is a plant that is used for human and animal consumption. This plant is also used for phytoremediation due to its relatively higher level of heavy metal tolerance. In South Africa, mining is one of the main drivers of the economy. One of the major negative environmental impacts of mining is heavy metal contamination. Soil metal content can rise to levels that are quite high and can even have a negative impact on the yields of B. napus crop. The glucosinolate-myrosinase system of B. napus is a system that is used as defence against biotic stressors. Indole glucosinolate breakdown products have been proven to enhance the antioxidant capacity of plants. Some have also shown growth promoting properties in plants. We studied the effect of exogenous DIM on B. napus and it role in Zr induced heavy metal stress. Germination percentages revealed that DIM increased germination, Zr application decreased germination and the DIMZr treatment reversed the negative impact of Zr application on B. napus. The effect of treatments on the biomass of B. napus was assessed by determining the dry weights. Results show that exogenous DIM improves biomass. Zr application decreased biomass and DIM-Zr treatment ameliorated the effect of Zr application.
2020-08-31
Gomez, Vargas Javier Alejandro. "Regulation of the signal transduction pathways of the unfolded protein response during chronic and physiological ER stresses." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/5760.
Повний текст джерела