Статті в журналах з теми "Stratum corneum swelling"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Stratum corneum swelling.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-22 статей у журналах для дослідження на тему "Stratum corneum swelling".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Malnati, Claudio, Daniel Fehr, Fabrizio Spano, and Mathias Bonmarin. "Modeling Stratum Corneum Swelling for the Optimization of Electrode-Based Skin Hydration Sensors." Sensors 21, no. 12 (June 9, 2021): 3986. http://dx.doi.org/10.3390/s21123986.
Повний текст джерелаАнотація:
We present a novel computational model of the human skin designed to investigate dielectric spectroscopy electrodes for stratum corneum hydration monitoring. The multilayer skin model allows for the swelling of the stratum corneum, as well as the variations of the dielectric properties under several hydration levels. According to the results, the stratum corneum thickness variations should not be neglected. For high hydration levels, swelling reduces the skin capacitance in comparison to a fixed stratum corneum thickness model. In addition, different fringing-field electrodes are evaluated in terms of sensitivity to the stratum corneum hydration level. As expected, both conductance and capacitance types of electrodes are influenced by the electrode geometry and dimension. However, the sensitivity of the conductance electrodes is more affected by dimension changes than the capacitance electrode leading to potential design optimization.
2
Norlén, L., Axel Emilson, and Bo Forslind. "Stratum corneum swelling. Biophysical and computer assisted quantitative assessments." Archives of Dermatological Research 289, no. 9 (September 12, 1997): 506–13. http://dx.doi.org/10.1007/s004030050231.
Повний текст джерела
3
Li, Xin, Robert Johnson, Ben Weinstein, Elizabeth Wilder, Ed Smith, and Gerald B. Kasting. "Dynamics of water transport and swelling in human stratum corneum." Chemical Engineering Science 138 (December 2015): 164–72. http://dx.doi.org/10.1016/j.ces.2015.08.009.
Повний текст джерела
4
Olmsted, Peter, Chinmay Das, and Massimo Noro. "Cholesterol Flip-Flop and Lack of Swelling in Stratum Corneum Lipid Bilayers." Biophysical Journal 108, no. 2 (January 2015): 413a. http://dx.doi.org/10.1016/j.bpj.2014.11.2264.
Повний текст джерела
5
Ohta, N., I. Hatta, S. Ban, H. Tanaka, and S. Nakata. "Swelling of lipid lamellae with short repeat distance in hairless mouse stratum corneum." Seibutsu Butsuri 41, supplement (2001): S133. http://dx.doi.org/10.2142/biophys.41.s133_1.
Повний текст джерела
6
박승환 and 하병조. "Study on Swelling and Rheological Properties of the Stratum Corneum under Various Moisturizers and pH Conditions." Journal of Investigative Cosmetology 6, no. 4 (December 2010): 401–6. http://dx.doi.org/10.15810/jic.2010.6.4.011.
Повний текст джерела
7
Pashkovski, Eugene, Efrem Braun, Daeyeon Lee, and David Weitz. "Permeability of Model Stratum Corneum Lipid Membrane Measured using Quartz Crystal Microbalance: Non-Fickian Diffusion and Transient Membrane Swelling." Biophysical Journal 98, no. 3 (January 2010): 481a. http://dx.doi.org/10.1016/j.bpj.2009.12.2618.
Повний текст джерела
8
Terzopoulou, Zoi, Anna Michopoulou, Artemis Palamidi, Elena Koliakou, and Dimitrios Bikiaris. "Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers." Polymers 12, no. 10 (October 17, 2020): 2393. http://dx.doi.org/10.3390/polym12102393.
Повний текст джерелаАнотація:
Patients with psoriasis are dissatisfied with the standard pharmacological treatments, whether systemic or topical, with many of them showing interest in complementary and alternative medicine. Curcumin (Cur), a natural polyphenol derived from turmeric, has recently gained attention for skin-related diseases because of its proven anti-inflammatory action. However, topical treatment with Cur would be inadequate because of its hydrophobicity, instability, and low bioavailability. In addition, hyperkeratosis and lack of moisture in psoriatic skin result in low penetration that would prevent actives from permeating the stratum corneum. In this work, a polymer-based formulation of Cur for the topical treatment of psoriasis is reported. To improve the physicochemical stability of Cur, it was first encapsulated in chitosan nanoparticles. The Cur-loaded nanoparticles were incorporated in a hydrophilic, biocompatible collagen-based patch. The nanoparticle-containing porous collagen patches were then chemically cross-linked. Morphology, chemical interactions, swelling ratio, enzymatic hydrolysis, and Cur release from the patches were evaluated. All patches showed excellent swelling ratio, up to ~1500%, and after cross-linking, the pore size decreased, and their hydrolysis rates decelerated. The in vitro release of Cur was sustained with an initial burst release, reaching 55% after 24 h. Cur within the scaffolds imparted a proliferation inhibitory effect on psoriatic human keratinocytes in vitro.
9
Ohta, Noboru, Sadanori Ban, Hiroshi Tanaka, Satoru Nakata, and Ichiro Hatta. "Swelling of intercellular lipid lamellar structure with short repeat distance in hairless mouse stratum corneum as studied by X-ray diffraction." Chemistry and Physics of Lipids 123, no. 1 (March 2003): 1–8. http://dx.doi.org/10.1016/s0009-3084(02)00126-3.
Повний текст джерела
10
Eckert, Ralph W., Sabrina Wiemann, and Cornelia M. Keck. "Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals." Molecules 26, no. 6 (March 15, 2021): 1633. http://dx.doi.org/10.3390/molecules26061633.
Повний текст джерелаАнотація:
Poor aqueous solubility of active compounds is a major issue in today’s drug delivery. In this study the smartFilm-technology was exploited to improve the dermal penetration efficacy of a poorly soluble active compound (curcumin). Results were compared to the dermal penetration efficacy of curcumin from curcumin bulk suspensions and nanocrystals, respectively. The smartFilms enabled an effective dermal and transdermal penetration of curcumin, whereas curcumin bulk- and nanosuspensions were less efficient when the curcumin content was similar to the curcumin content in the smartFilms. Interestingly, it was found that increasing numbers of curcumin particles within the suspensions increased the passive dermal penetration of curcumin. The effect is caused by an aqueous meniscus that is created between particle and skin if the dispersion medium evaporates. The connecting liquid meniscus causes a local swelling of the stratum corneum and maintains a high local concentration gradient between drug particles and skin. Thus, leading to a high local passive dermal penetration of curcumin. The findings suggest a new dermal penetration mechanism for active compounds from nano-particulate drug delivery systems, which can be the base for the development of topical drug products with improved penetration efficacy in the future.
11
Kashutin, S. L., E. I. Tedder, Leonid L. Shagrov, N. A. Shutskiy, V. S. Nekludova, K. K. Korolev, and D. E. Aristov. "MORPHOLOGICAL CHARACTERISTICS OF EPIDERMIS AND DERMIS IN PATIENTS WITH DIFFUSE ALOPECIA, ANDROGENETIC ALOPECIA AND ALOPECIA AREATA." Russian Journal of Skin and Venereal Diseases 21, no. 2 (April 15, 2018): 106–9. http://dx.doi.org/10.18821/1560-9588-2018-21-2-106-109.
Повний текст джерелаАнотація:
Despite the emergence of non-invasive and very informative techniques, such as trichoscopy and confocal microscopy, it is still necessary to use a skin biopsy of the scalp. Currently, there is a lot of information about hystopathology of the scalp in patients with diffuse alopecia, androgenetic alopecia and alopecia areata [1]. Researches mostly aim to study the follicular unit, whereas data on pathological changes in the epidermis, papillary and reticular dermis in the above-mentioned alopecia are rare and scattered. In this connection, the aim of the research was to study morphological characteristics of epidermis and dermis in patients with diffuse alopecia, androgenetic alopecia and alopecia areata. Material and methods. We examined 25 patients (12 women and 13 men) aged 17 to 60 years with not cicatricial alopecia: androgenetic alopecia was observed in 10 patients, alopecia areata - in 9 patients, diffuse alopecia - in 6 patients. The age of the disease ranged from 1 month to 5 years. The control group consisted of 9 people. The review microscopy and morphometry of samples, taken for investigation, were performed using the eyepiece micrometer MOB-1-15xУ4.2. The following indicators in the dermis were evaluated: the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis, mucoid swelling of sclerosis of the papillary dermis, and signs of destruction of hair follicles. Results. The tendency to increase thickness of the epidermis in patients with diffuse alopecia is associated with thickening of the stratum granulosum and especially the stratum corneum. In case of androgenetic alopecia and alopecia areata the tendency to decrease the thickness of the epidermis is associated with a tendency to reduce the thickness of the stratum lucidum. Regardless of the type of alopecia, the thickness of the stratum basale is statistically higher than in the control group. Regardless of the type of alopecia, changes in the dermis are manifested by the destruction of hair follicles followed by the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis, as well as sclerosis of the papillary dermis. Discussion. It can be anticipated that the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis may indicate the inflammatory process, which is accompanied by abnormal microcirculation and the destruction of the hair follicle which in turn insufficiently stimulates angiogenesis.
12
Kim, Jong Seo. "Detailed Sonographic Anatomy of Dorsal Hand Augmentation With Hyaluronic Acid and Calcium Hydroxyapatite Fillers." Aesthetic Surgery Journal 39, no. 10 (September 5, 2018): 1096–106. http://dx.doi.org/10.1093/asj/sjy227.
Повний текст джерелаАнотація:
Abstract Background Volume restoration using filler in the dorsum of the hand is a simple and effective procedure to improve wrinkles and hide veins and tendons. Currently, calcium-hydroxyapatite (CaHA) filler is the only FDA-accepted material to use in the hand dorsum. However, it is not easy to inject due to swelling and redness. In addition, hand anatomy through sonography is wrongly described in Plastic and Reconstructive Surgery® Journal. Through incorrect marking in sonographic hand anatomy, physicians will conduct erroneous procedures and surgeries. Objectives CaHA filler and hyaluronic acid (HA) filler were both injected into the hand to compare intra-individually the effect of each filler. Through this study, the author introduced detailed and refined sonographic anatomy. Overall, the author identified the correct injection method and depth. Methods In this prospective, intra-individual, comparative study, patients were injected 1 cc of CaHA filler to the left hand and 3 cc (36 mg) of microphasic hyaluronic acid to the right. Outcomes were assessed by Merz hand grading scale, skin bio-parameters, dermascopic finding, and Global Aesthetic Improvement Scale (GAIS) with follow-up at 3, 6, 9, and 12 months. Results The average GAIS score improved in both hands and generally maintained over the course of the study. There was significantly more bruising and swelling in the CaHA-injected hands compared with the HA-injected hands. The skin roughness and appearance improved in both sets of hands on dermascope. The average Trans-Epidermal-Water-Loss decreased and the average Stratum Corneum Hydration increased in HA-injected hands. The biopsy study showed that the HA particles lasted for 9 months. Conclusions The author reestablished sonographic anatomy. Veins and tendons became less apparent after injections. Level of Evidence: 2
13
Withers, Philip C. "Evaporative water loss and the role of cocoon formation in Australian frogs." Australian Journal of Zoology 46, no. 5 (1998): 405. http://dx.doi.org/10.1071/zo98013.
Повний текст джерелаАнотація:
Measurements of evaporative water loss (EWL; mg min-1) and resistance (R; sec cm-1) for various Australian frogs indicate three general allometric patterns: non-cocooned and non-‘waterproof’ frogs with EWL ∝ Mass0.30 and R independent of body mass at about 1–3 sec cm-1, cocooned frogs with EWL reduced about 50–200-fold and R about 50–200 sec cm-1, and ‘waterproof’ frogs with EWL reduced about 5–100- fold and R about 5–100 sec cm-1. Cocooned frogs have an exponential reduction in EWL and fairly linear increase in R over time, corresponding to the temporal addition of layers to the cocoon. The biophysical properties of cocoon are generally similar for various species, although there is some variation in both resistance per thickness (5–20 × 104 s cm-2) and diffusion coefficient (0.4–2.4 × 10 –5 cm2 s-1). The hygroscopic property of frog cocoon resembles that of mammalian stratum corneum, hair and wool, and mucopolysaccharides; there is a slight increase in water content of cocoon over a wide range of humidities but a very steep increase in water content and substantial hydration and swelling at >96% RH. This extreme hygroscopic behaviour of frog cocoon at very high RH may reflect less polymer cross-linking in frog cocoon and its high digestibility. The prevention of over-hydration of frog cocoon in vivo may be attributed to the restriction of high water content to only very high RH (>96%).
14
Sato, K., D. E. Timm, F. Sato, E. A. Templeton, D. S. Meletiou, T. Toyomoto, G. Soos, and S. K. Sato. "Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water." Journal of Applied Physiology 75, no. 5 (November 1, 1993): 2258–64. http://dx.doi.org/10.1152/jappl.1993.75.5.2258.
Повний текст джерелаАнотація:
Passing galvanic current across the skin (known as "tap water iontophoresis" or TWI) inhibits sweating; however, its mechanism of action is unclear. Using improved methods, we confirmed that anodal current has more of an inhibitory effect than cathodal current, water is superior to saline, and the inhibitory effect is a function of the amperage used. To address the importance of current flowing through the pores, a layer of silicone grease was placed on the skin to reduce the shunt pathway across the epidermis. With silicone, total skin conductance decreased 60% without the sweat pores being occluded, swelling of the stratum corneum and collapse of the poral lumen was prevented, and current-induced inhibition of sweating was enhanced, most likely because of an increase in current density in the pores. The pH of anodal water, but not of saline, dropped to 3, whereas that of cathodal water increased to 10 during passage of current through the skin. Acidified anodal water was superior to alkaline water. Sweat glands isolated from TWI-induced anhidrotic palmar skin responded to methacholine in vitro, but the sweat rate and pharmacological sensitivity were slightly lowered. Thus the strong acidity generated by hydrolysis of water in the anodal bath and the further accumulation of H+ in the sweat duct by anodal current may be responsible for TWI-induced inhibition of sweating due to an unknown lesion(s) in the duct or sweat pore. The secretory coil function may also be altered because of exposure to intense acidity during TWI. The importance of H+ movement into the sweat pore for inhibition of sweating could be further exploited to develop new strategies for the control of sweating.
15
Allen, E., Q. C. Yu, and E. Fuchs. "Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation." Journal of Cell Biology 133, no. 6 (June 15, 1996): 1367–82. http://dx.doi.org/10.1083/jcb.133.6.1367.
Повний текст джерелаАнотація:
Desmogleins are members of the cadherin superfamily which form the core of desmosomes. In vitro studies indicate that the cytoplasmic domain of desmogleins associates with plakoglobin; however, little is known about the role of this domain in desmosome recognition or assembly in vivo, or about the possible relation of desmoglein mutations to epidermal differentiation and disease. To address these questions we used transgenic mouse technology to produce an NH2-terminally truncated desmoglein (Pemphigus Vulgaris Antigen or Dsg3) in cells known to express its wild-type counterpart. Within 2 d, newborn transgenic animals displayed swelling of their paws, flakiness on their back, and blackening of the tail tip. When analyzed histologically and ultrastructurally, widening of intercellular spaces and disruption of desmosomes were especially striking in the paws and tail. Desmosomes were reduced dramatically in number and were smaller and often peculiar in structure. Immunofluorescence and immunoelectron microscopy revealed no major abnormalities in localization of hemidesmosomal components, but desmosomal components organized aberrantly, resulting in a loss of ultrastructure within the plaque. In regions where desmosome loss was prevalent but where some adhesive structures persisted, the epidermis was thickened, with a marked increase in spinous and stratum corneum layers, variability in granular layer thickness, and parakeratosis in some regions. Intriguingly, a dramatic increase in cell proliferation was also observed concomitant with biochemical changes, including alterations in integrin expression, known to be associated with hyperproliferation. An inflammatory response was also detected in some skin regions. Collectively, these findings demonstrate that a mutation in a desmoglein can perturb epidermal cell-cell adhesion, triggering a cascade of changes in the skin.
16
Frombach, Janna, Fiorenza Rancan, Katharina Kübrich, Fabian Schumacher, Michael Unbehauen, Ulrike Blume-Peytavi, Rainer Haag, et al. "Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers." Pharmaceutics 12, no. 9 (September 10, 2020): 862. http://dx.doi.org/10.3390/pharmaceutics12090862.
Повний текст джерелаАнотація:
Standard experimental set-ups for the assessment of skin penetration are typically performed on skin explants with an intact skin barrier or after a partial mechanical or chemical perturbation of the stratum corneum, but they do not take into account biochemical changes. Among the various pathological alterations in inflamed skin, aberrant serine protease (SP) activity directly affects the biochemical environment in the superficial compartments, which interact with topically applied formulations. It further impacts the skin barrier structure and is a key regulator of inflammatory mediators. Herein, we used short-term cultures of ex vivo human skin treated with trypsin and plasmin as inflammatory stimuli to assess the penetration and biological effects of the anti-inflammatory drug dexamethasone (DXM), encapsulated in core multishell-nanocarriers (CMS-NC), when compared to a standard cream formulation. Despite a high interindividual variability, the combined pretreatment of the skin resulted in an average 2.5-fold increase of the transepidermal water loss and swelling of the epidermis, as assessed by optical coherence tomography, as well as in a moderate increase of a broad spectrum of proinflammatory mediators of clinical relevance. The topical application of DXM-loaded CMS-NC or DXM standard cream revealed an increased penetration into SP-treated skin when compared to untreated control skin with an intact barrier. Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP). In conclusion, we suggest that the herein presented ex vivo inflammatory skin model is functional and could improve the selection of promising drug delivery strategies for anti-inflammatory compounds at early stages of development.
17
Mishra, Rakhi, Shradha Shende, Prabhat Kumar Jain, and Vivek Jain. "FORMULATION AND EVALUATION OF GEL CONTAINING ETHOSOMES ENTRAPPED WITH TRETINOIN." Journal of Drug Delivery and Therapeutics 8, no. 5-s (October 1, 2018): 315–21. http://dx.doi.org/10.22270/jddt.v8i5-s.1982.
Повний текст джерелаАнотація:
A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of ethosomes which can be transported through the skin through channel-like structures. Tretinoin is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized for entrapment efficiency, vesicular size, shape, In-vitro skin permeation, skin retention, drug‐membrane component interaction and stability. The ethosomal formulation having 0.5 %w/v of phospholipid and 20 %v/v of ethanol (F2) showing the greatest entrapment efficiency (80.25±0.23) with small particle size (205.40±2.31nm) was selected for further skin permeation studies. The skin permeation and skin retention studies were performed on ethosomal formulation, liposomal formulation (0.5 %w/v of phospholipid without alcohol), hydroethanolic drug solution and phosphate buffer saline (pH7.4) drug solution. Among them, ethosomal formulation showed higher cumulative percentage of drug permeation (93.36±0.45%) and 8 hours than the other formulations. Scanning electron microscopy confirmed the three dimensional nature of ethosomes. Dynamic light scattering technique proved that the ethosomes has smaller vesicular size than the liposomes prepared without alcohol. FT‐IR studies revealed no interaction between the drug and membrane components. The ethosomal vesicles were incorporated in carbopol gel base and its anti‐acne was compared with the marketed gel. Our results suggest that the ethosomes are an efficient carrier for dermal and transdermal delivery of tretinoin.
Keywords: Tretinoin, Ethosomes, Diffusion, Carbopol gels, Transdermal delivery.
18
Li, Jingyuan, Hong Xiang, Qian Zhang, and Xiaoqing Miao. "Polysaccharide-Based Transdermal Drug Delivery." Pharmaceuticals 15, no. 5 (May 14, 2022): 602. http://dx.doi.org/10.3390/ph15050602.
Повний текст джерелаАнотація:
Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.
19
Pulini, Stefano, Serena Rupoli, Nicola Pimpinelli, Annalisa Natale, Gaia Goteri, Anna Rita Scortechini, Paola Picardi, Simonetta Mulattieri, Pietro Leoni, and Giuseppe Fioritoni. "Pegylated Liposomal Doxorubicin in Primary Cutaneous Lymphomas: Efficacy, Safety, and Low Rate of Palmar-Plantar Erythrodysesthesia." Blood 112, no. 11 (November 16, 2008): 4932. http://dx.doi.org/10.1182/blood.v112.11.4932.4932.
Повний текст джерелаАнотація:
Abstract Pegylated liposomal doxorubicin (PLD) is approved in breast cancer, ovarian cancer, Kaposi’s sarcoma. Its skin-tropism suggests a role in the therapy of primary cutaneous lymphomas (PCLs). Among the cutaneous toxicities of PLD, the palmar-plantar erythrodysesthesia (PPE) is characterized by tingling, dysesthesia, erythema, swelling and, in severe cases desquamation, crusting, ulceration and necrosis. PPE is dose- and schedule-dependent and is usually reversible. Different pathophysiologic mechanisms are suggested: PLD, excreted from sweat glands, penetrates into the corneum stratum with local oxidative and inflammatory reactions; direct cytotoxic effect; extravasation of PLD from the deep microvessels through the local pressure. At our knowledge no specific reports on PPE in patients (pts) with PCLs treated with PLD were presented. We report 31 PCL pts treated with PLD: 26 affected by primary cutaneous T-cell lymphomas (PCTCL) and 5 by primary cutaneous B-cell lymphomas (PCBLC). Among PCTLC, 21 pts (16 M, 5 W, median age 67 yrs) received PLD in monotherapy at the dosage of 20 mg/m2 every 3–4 weeks. They were affected by relapsed or refractory PCTCLs: Mycosis Fungoides (MF) (52%), transformed MF in large cell lymphoma (20%), Sèzary Syndrome (SS) (14%), peripheral T-cell lymphoma unspecified (PTCL–U) (14%). After 6 courses, 47% achieved a CR, with ORR of 81%. The median time to the max response was 3 mo.s. After a median follow-up of 36 months 5 pts had progression of disease (PD) and 5 relapsed. To date 9 pts are alive and 12 dead, 4 for PD and 8 for non-related causes. Median OS, EFS and PFS are 36, 17 and 19 mo.s respectively; OS, EFS and PFS rates at 66 mo.s are 33%, 16% and 37%, respectively. Among the remaining 5 PCTLC pts one with transformed MF in large cell lymphoma was treated with PLD in monotherapy and then intensified with bortezomib and dexamethasone obtaining a VGPR. Another pt with PTCL-U received PLD plus rituximab with a CR and the last 3 pts (MF, MF transformed and SS) underwent CBVD scheme obtaining a PR. Among the 5 PCBCLs a woman was affected by marginal zone lymphoma (PCMZL) and 4 men by large B-cell lymphoma (PCLBCL) (all in stage: T3,N0,M0). All pts showed a CR with PLD monotherapy, in a short period (median 2,5 mo.s), even when heavily pretreated. One of them experienced a relapse. One died for PD; to date the others are still in CR after 5, 52, 63 and 69 mo.s. PLD was well tolerated. In PCTLC adverse effects were observed in 6 pts (23%) and grade III–IV toxicity occurred in 2 (8%): capillary leakage syndrome and neutropenia. Nobody required dose modifications or delays. Grade II gastrointestinal toxicity was present in 2 pts. Only two showed a grade I PPE. In these cases we delayed the dose up to 1 week, obtaining a complete resolution, thus returning to the original interval. Even in the five pts affected by PCBCL, PLD was well tolerated and no one decreased or delayed the dose. A pt showed a reversibile grade I neurotoxicity; the hematological toxicity was mild with one case of grade III neutropenia treated with G-CSF. Nobody experienced PPE. PPE is frequently reported in pts with cancer treated with PLD: about 50% off all pts who received the currently approved dose of 50 mg/m2 every 4 weeks experienced PPE and about 20% grade III PPE. When PPE develops, PLD dose reduction, schedule modification, ultimately drug withdrawal are considered. In our pts affected by PCLs, PPE occurred rarely, with mild grade (2 case of grade I). It is probably due to low dosages of Peg-Doxo, compared to the commonly used in other solid neoplasms. Besides oral prophylaxis with pyridoxine 300 mg daily was administered from the beginning of the treatment until 1 month after its discontinuation in all pts, as suggested by some authors. This is the first report of PLD in PCBCL; as regarding the other few studies (Wollina, Cantonetti, Di Lorenzo, Lybaek, Quereux) concerning PLD in PCTLC the incidence of PPE resulted always low. In conclusion, it emerges that PLD shows a significantly high clinical activity and a good safety profile in PCLs. Our data seem to confirm the dose dependent toxicity effect of PLD, since three-four weekly schedule of PLD at the dose of 20 mg/m2 has less PPE compared to the classical schedule of 50 mg/m2 every 4 weeks. Some studies in ovarian and breast cancer demonstrated that PLD dose intensity reduction can prevent PPE. The administration of prophylactic pyridoxine seems to be useful in the reduction of the incidence and severity of PPE.
20
Hodel, Katharine Valéria Saraiva, Bruna Aparecida Souza Machado, Giulia da Costa Sacramento, Carine Assunção de Oliveira Maciel, Gessualdo Seixas Oliveira-Junior, Breno Noronha Matos, Guilherme Martins Gelfuso, Silmar Baptista Nunes, Josiane Dantas Viana Barbosa, and Ana Leonor Pardo Campos Godoy. "Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment." Pharmaceutics 14, no. 6 (June 8, 2022): 1222. http://dx.doi.org/10.3390/pharmaceutics14061222.
Повний текст джерелаАнотація:
The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T600 mm−1), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m2 day−1), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL−1). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.
21
Дуллах, Арам, І. О. Власенко, Г. М. Войтенко та Л. Л. Давтян. "ВИВЧЕННЯ ПРОТИЗАПАЛЬНОЇ АКТИВНОСТІ ОПРАЦЬОВАНОГО КРЕМУ БЕТАКАРБОКЛОМЕТ". Фармацевтичний часопис, № 3 (8 жовтня 2015). http://dx.doi.org/10.11603/2312-0967.2015.3.4941.
Повний текст джерелаАнотація:
<p><strong>STUDY OF ANTIINFLAMMATORY ACTIVITY OF FORMULTATED CREAM BETAKARBOKLOMET</strong></p><p><strong>Aram Dullah, </strong><strong>I</strong><strong>.</strong><strong>O</strong><strong>.Vlasenko, </strong><strong>G</strong><strong>.</strong><strong>M</strong><strong>. </strong><strong>Voytenko</strong><strong>,</strong> <strong>L.L. Davtyan </strong></p><p><em>Shupik</em><em> </em><em>National</em><em> </em><em>medical</em><em> </em><em>academy</em><em> </em><em>of</em><em> </em><em>postgraduate education </em><strong></strong></p><p><strong>Summary:</strong> The article presents the results of a study of antiexudative activity of complexed antifungal cream, based on clotrimazole, betamethasone dipropionate, metronidazole and urea, for treatment of dermatomycosis. By in vivo method (model of acute aseptic (dextran) inflammation) it was found that the formulated cream has antiinflammatory activity typical for glucocorticoids, dynamics and the value of which correspond to the activity of referent-medicine.</p><p><strong>Keywords: </strong>dermatomycosis, betamethasone diptopionate, antiexudative activity.</p><pre><strong>Introduction.</strong> Last years are characterized by marked increase in the incidence of fungal diseases, foot fungal infections take one of the highest incidence of skin diseases. They are often characterized by thickening of the stratum corneum layer of the foot’s skin, cracks and inflammation, causing pain and itching. The long term of mycological process leads to profound disorders of the body, complicating other diseases and reduces the quality of life.</pre><pre>When dermatomycosis is accompanied by inflammatory reaction of the skin combined using of antifungal agents and corticosteroids of local action is recommended. </pre><pre>Based on pharmaco- technological, physical, chemical and biological research mild drug (MDL) for complex treatment of dermatomycoses based on clotrimazole, metronidazole, urea and betamethasone dipropionate named Betakarboklomet was developed. </pre><pre>The purpose of the study was to investigate the anti-inflammatory activity of developed MDL .</pre><pre><strong>Methods</strong><strong>.</strong> The study of MDL’s antiexudative activity conducted on a model of acute aseptic ( dextrane) inflammation by oncometric method was conducted. Exudative inflammation was assessed by measuring the volume of paw dynamics.</pre><p><strong>Results</strong><strong> </strong><strong>and</strong><strong> </strong><strong>discussion</strong>.</p><pre>The maximum increase in the volume of inflamed foot was observed within 1 hour after introduction of dextran, averaging 0.78 ml. In the next 5 hours foot swelling gradually decreased, but the output volume is not returned.</pre><pre>The study found that processed cream has expressed antiexudative activity, which is not significantly different from the reference product. Increase the volume of the paw of animals applied by drug Betakarboklomet was at the peak of edema (1 hour) 0,52 ± 0,02 ml , 3 h paw’s growth of volume of the original volume was 0,36 ± 0,02 ml, 5 hours - 0,20 ± 0,01 ml. The average value of MDL action for 5 hours was about 50.98 %, and for the reference product - 47.47 %.</pre><pre>Ability of developed cream Betakarboklomet to inhibit inflammation in the early stages manifested by betamethasone dipropionate, which, according to the literature, is able to reduce the synthesis of prostaglandins , prostacyclin, and others. Thus, our study of impact of developed cream Betakarboklomet on inflammation, suggests that MDL has a strong anti-inflammatory effect ( inhibits the development of serotonin edema).</pre><pre><strong>Conclusions</strong><strong>.</strong> Based on pharmacological studies of experimental inflammation induced by dextran, developed drug Betakarboklomet shows anti-inflammatory effect at the prototype.</pre>
22
Гагарин, Е. М., Л. А. Глазунова, and М. В. Доронина. "Comparative analysis of morphological changes in the tissues of the base of the hoof skin in the ulcerative process of Mortellaro." VESTNIK RIAZANSKOGO GOSUDARSTVENNOGO AGROTEHNOLOGICHESKOGO UNIVERSITETA IM P A KOSTYCHEVA, no. 4(52) (December 27, 2021). http://dx.doi.org/10.36508/rsatu.2021.23.30.005.
Повний текст джерелаАнотація:
Проблема и цель. Целью исследований явилось проведение анализа данных гистологии препаратов тканей и их сравнительной характеристики с контрольными гистопрепаратами, а также установление происходящих морфологических изменений в поверхностных и глубоких слоях дермы в области межкопытцевой щели при развитии воспалительной реакции и формировании язвенного процесса Мортелларо. Методология. Для достижения поставленной цели произведен отбор мягких тканей в области копытца и венчика у высокопродуктивных животных (крупный рогатый скот голштинской породы) в возрасте 1-й и 2-й лактаций для проведения гистологических исследований: 20 глубоких проб в области основы кожи копытец с эпидермисом (треугольные кусочки размером 0,5*0,5*0,5 см и 0,5-0,7 см вглубь до кровеносных сосудов) у клинически здоровых животных разовым скальпелем после предварительной обработки антисептиком и местного обезболивания раствором лидокаина 2 %-м с последующим наложением антисептической повязки (контроль).Для проведения сравнительной характеристики, гистологического исследования и обнаружения патоморфологических изменений в области язвенных процессов Мортелларо и Рустергольца соответственно отобрано по 5 образцов мягких тканей, взятых у животных с поражениями копытец различной степени тяжести по 5-балльной шкале Карла Бурги и Нигеля Б. Кука по каждой степени тяжести соответственно (50 проб). Гистологические препараты окрашивали по двум методикам: стандартное окрашивание гематоксилином и эозином и окрашивание толуидиновым синим для обнаружения признаков фибриноидного набухания (препараты нормы – для визуального контроля). Результаты. В зависимости от степени тяжести клинических проявлений от 1-й до 5-й происходит ряд морфологических изменений в тканях верхних слоев дермы в области межкопытцевой щели при язве Мортелларо: толщина рогового слоя у животных опытной группы изменялась от 3 мм до полного расплавления; длина акантотических тяжей от 3 мм до 1,5 мм; при поражении 5-й степени тяжести отмечены их дистрофические изменения. При прогрессировании степени тяжести патологического процесса увеличивается количество паретически расширенных венул, артерии спазмируются. Со стороны дермы нарастает воспалительная инфильтрация сегментоядерными лейкоцитами с примесью плазмоцитов и лимфоцитов. Заключение. Обнаруженные в образцах тканей, отобранных с области язвенного поражения Мортелларо, особенности изменений в сосочковом слое дермы – паретическое расширение более чем половины венул с признаками полнокровия при одновременном спазмировании практически всех мелких артерий, могут приводить к повышению давления на сосуды (венулы, артериолы). При этом сдавливание сосудов приводит к местной гипоксии тканей, накоплению свободных радикалов, которые «бомбардируют» клетки глубинных слоев дермы, возникают процессы дегенерации тканей. Problem and purpose. The aim of the research was to analyze the histology data of tissue preparations and their comparative characteristics with control histological preparations, as well as to establish the ongoing morphological changes in the superfcial and deep layers of the dermis in the interdigital fssure during the development of an infammatory reaction and the formation of the Mortellaro ulcerative process. Methodology. To achieve this goal, soft tissues were selected in the area of the hoof and corolla from highly productive animals (cattle of the Holstein breed) at the age of 1 and 2 lactations for histological studies: 20 deep samples in the area of the skin base of the hooves with epidermis (triangular pieces of size 0, 5 * 0.5 * 0.5 cm and 0.5-0.7 cm deep to the blood vessels) in clinically healthy animals with a single scalpel after pretreatment with an antiseptic and local anesthesia with a 2% lidocaine solution followed by the application of an antiseptic bandage (control ). For comparative characteristics, histological examination and detection of pathomorphological changes in the ulcerative processes of Mortellaro and Rustergolz, respectively, 5 soft tissue samples were taken from animals with hoof lesions of varying severity according to the 5-point scale of Karl Burgi and Nigel B. Cook for each degree severity, respectively (50 samples). Histological preparations were stained according to two methods: standard staining with hematoxylin and eosin and staining with toluidine blue to detect signs of fbrinoid swelling (standard preparations - for visual control) .. Results. Depending on the severity of clinical manifestations from 1 to 5, a number of morphological changes occur in the tissues of the upper layers of the dermis in the area of the interdigital fssure in Mortellaro's ulcer: the thickness of the stratum corneum in animals of the experimental group varied from 3 mm to complete melting, the length of the acanthotic cords from 3 mm to 1.5 mm, with a lesion of the 5th degree of severity, their dystrophic changes were noted. With the progression of the severity of the pathological process, the number of paretic dilated venules increases, the arteries spasm. From the side of the dermis, infammatory infltration of segmented leukocytes with an admixture of plasma cells and lymphocytes is growing. Conclusion. The features of changes in the papillary layer of the dermis found in tissue samples taken from the area of ulcerative lesion of Mortellaro - paretic expansion of more than half of the venules with signs of plethora with simultaneous spasm of almost all small arteries, can lead to an increase in pressure on the vessels (venules, arterioles). At the same time, the compression of the vessels leads to local tissue hypoxia, the accumulation of free radicals, which "bombard" the cells of the deep layers of the dermis, and tissue degeneration processes occur.