Добірка наукової літератури з теми "Storck, Peter L"

Guppy fish Poecilia reticulata is one of the most popular freshwater ornamental fish species because it is easy to main-tain, and has beautiful variations of color, especially males. One method to produce male guppy is masculinization me-thod. This study aimed to determine the dose of hormone treatment from visceral organ of sea cucumber to the process masculinization of fish guppy. This study used a completely randomized design with the immersion treatment of parent guppy which has been bred into the extract solution of sea cucumber innards for 24 hours with different doses i.e. 0 mg L-1, 10 mg L-1, 20 mg L-1, 30 mg L-1 and 22 mg L-1 (metiltestosterone as positive control). The parameter measured was the percentage of male fish produced. The results showed that although the effect of the treatment was not significantly different, but it can be said to be significantly different to the treatment of 0 mg L-1 (control) to obtain the best result for masculinization of guppy at 30 mg L-1 immersion and the best survival rate on treatment of 0 mg L-1 (control). The re-sults of this study suggest that the masculinization technology on the parent stock can be done using extracts of sea cu-cumber innards which has been considered as waste.AbstrakIkan gapi Poecilia reticulata merupakan salah satu jenis ikan hias air tawar yang banyak digemari karena mudah dipe-lihara, dan memiliki variasi wama yang indah, terutama jantannya. Salah satu metode untuk menghasilkan ikan gapi jantan adalah dengan metode pembalikan kelamin melalui produksi penjantanan ikan gapi. Penelitian ini bertujuan un-tuk menentukan dosis hormon perlakuan ekstrak jeroan teripang pasir terhadap proses penjantanan ikan gapi. Penelitian ini menggunakan rancangan acak lengkap dengan perlakuan perendaman induk ikan gapi yang telah dipijahkan ke dalam larutan ekstrak jeroan teripang pasir selama 24 jam dengan dosis berbeda, yaitu 0 mg L-1, 10 mg L-1, 20 mg L-1, 30 mg L-1 dan 22 mg L-1 (metiltestosteron sebagai kontrol positif). Parameter yang diukur adalah persentase ikan jantan yang dihasilkan. Hasil penelitian menunjukkan bahwa walaupun pengaruh antarperlakuan yang diberikan tidak berbeda nyata, tetapi dapat dikatakan berbeda nyata terhadap perlakuan 0 mg L-1 (kontrol) sehingga diperoleh hasil terbaik untuk penjantanan ikan gapi pada dosis perendaman 30 mg L-1 dan sintasan terbaik pada perlakuan 0 mg L-1 (kontrol). Hasil penelitian ini memberikan informasi bahwa teknologi penjantanan pada induk ikan gapi dapat dilakukan dengan me-manfaatkan ekstrak jeroan teripang pasir yang selama ini dianggap sebagai limbah.

Abstract In a survey of 31 informational world cities, we investigate the state of the art public library core services. For this study, we applied the core service catalog developed by (Mainka, A., S. Hartmann, L. Orszullok, I. Peters, A. Stallmann, and W. G. Stock. 2013. “Public Libraries in the Knowledge Society: Core Services of Libraries in Informational World Cities.” Libri 63 (4): 295–319. 10.1515/libri-2013-0024), counted the services offered by the libraries and compared findings with the results from 2013, allowing us to calculate a score for each library and rank them accordingly. An overall improvement of the range of services was observed, with North American libraries taking the top three positions in the ranking. To get a clearer picture of the challenges facing libraries today, personal interviews were also conducted with (chief) librarians, especially concerning developments such as maker spaces, increasing demand for information literacy instruction and the changing role of physical library space. The results presented in this paper highlight best practice examples of library services in prototypical cities of the knowledge society.

BackgroundPain significantly impacts life of patients with rheumatoid arthritis (RA) (1). Besides articular pain due to systemic inflammation, neuropathic pain (NeP) represents another challenge that can pose a considerable burden on the life of patients (2).ObjectivesTo investigate persisting pain in RA patients and to analyse NeP along with patient-reported outcomes (PROs).MethodsPAIN-CONTROL is a prospective, non-interventional study in rheumatology centres in Germany. Inclusion criteria were fulfilment of the 2010 ACR/EULAR RA classification criteria, disease duration ≤ 8 yrs, DAS28 > 3.2, SJC > 3, CRP normal or above reference range, and pain rating ≥ 50 (0-100 VAS). Eligible subjects had to be scheduled for escalation of anti-inflammatory treatment according to national guidelines. At wk 24 subjects were allocated to three subgroups given DAS28-CRP change and VAS pain: i) reference group: VAS pain < 50 with either DAS28 improvement > 1.2 or DAS28 ≤ 3.2, ii) non-responders: DAS28 improvement ≤ 1.2 and DAS28 > 3.2 with or without pain alleviation, iii) persisting pain: VAS pain ≥ 50 with either DAS28 improvement > 1.2 or DAS28 ≤ 3.2. For groups 1 and 2 end of study was at week 24, patients with persisting pain continued until wk 48. Patients were assessed for NeP using a score of ≥ 19 in the painDETECT questionnaire (PD-Q) (3). Pain-related PROs, i.e. the Rheumatoid Arthritis Impact of Disease Questionnaire (RAID) and the Patient Health Questionnaire (PHQ-9), were analysed along with demographic background information (1,4). Descriptive results are presented as mean (SD) or mean (SD) | Nvalid, as well as n (%) or n (%) | Nvalid, respectively.Results567 subjects were analysed with the following distribution: Reference group 337 (59.4%), non-responders 102 (18.0%), and persisting pain 128 (22.6%), of which 115 patients were available at wk 48. Subgroups showed similar demographic baseline characteristics but differed in PROs (Table 1). Until wk 24, proportion of patients with NeP indication decreased in the reference group (-19.8%) and slightly in non-responders (-6.0%) and persisting pain group (-9.5%). Non-responders showed the highest NeP proportion at wk 24 (35.0%) (Table 1). Of 115 patients with persisting pain at wk 24, 47 (40.9%) tested NeP negative at wk 48, 21 (18.3%) tested unclear, 28 (24.3%) were missing and 19 (16.5%) tested positive. Of the latter 9 patients (47.4%) still had persisting pain at week 48, while this was the case for 14 patients (29.8%) in the former group. 49 (42.6%) of 115 patients with severe persisting pain at wk 24 reported pain alleviation at wk 48 and fulfillment of reference group criteria. RAID and PHQ-9 scores improved in the reference group but only slightly in the other two subgroups.Table 1.Demographic background and PROsCharacteristicReference group(N = 337)Non-responders(N = 102)Persisting pain(N = 128)Gender (f/m)233 (69.1%) /65 (63.7%) /87 (68.0%) /104 (30.9%)37 (36.3%)41 (32.0%)Age57.1 (13.2) | 33759.9 (12.0) | 10257.1 (13.0) | 128Disease duration (yrs)2.5 (2.6) | 3372.7 (2.8) | 1022.5 (2.5) | 128PD-Q (≥ 19) (Bl)82 (28.6%) | 28732 (41.0%) | 7840 (36.0%) | 111PD-Q (≥ 19) (wk 24)21 (8.8%) | 23928 (35.0%) | 8027 (26.5%) | 102PD-Q (Bl)14.0 (6.8) | 28715.5 (7.1) | 7815.5 (6.5) | 111PD-Q (wk 24)8.8 (5.8) | 23914.8 (6.7) | 8013.8 (7.2) | 102RAID (Bl)5.8 (2.0) | 3326.0 (1.9) | 1006.6 (1.7) | 125RAID (wk 24)2.4 (1.8) | 3215.4 (1.9) | 975.1 (1.9) | 123PHQ-9 (Bl)7.3 (5.1) | 3288.4 (5.4) | 987.9 (5.1) | 123PHQ-9 (wk 24)3.8 (3.5) | 3187.3 (4.5) | 956.6 (4.5) | 122ConclusionNeP is common among RA non-responders to anti-inflammatory treatment and in patients with persisting pain, meriting a routine NeP screening to more adequately address persisting pain in these patients. However, even late improvements (after 24 wks) regarding persisting pain seem likely during anti-inflammatory treatment.References[1]Gossec L, Ann Rheum Dis. 2011 Jun;70(6):935–42.[2]Noda K, Mod Rheumatol. 2020 Sep;30(5):828–34.[3]Freynhagen R, Curr Med Res Opin. 2006 Oct;22(10):1911–20.[4]Kroenke K, J Gen Intern Med. 2001 Sep;16(9):606–13.AcknowledgementsStatistical analysis was provided under lead of Dr. Daniela Adolf of StatConsult GmbH, which was funded by AbbVie.Medical writing support was provided by Dr. Matthias Englbrecht of Statscoach, which was funded by AbbVie.Disclosure of InterestsChristoph Baerwald Speakers bureau: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Consultant of: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Grant/research support from: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Edgar Stemmler Shareholder of: Dr. Edgar Stemmler is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Edgar Stemmler is employee of AbbVie and may own AbbVie stock., Sixten Gnuechtel Shareholder of: Dr. Sixten Gnüchtel is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Sixten Gnüchtel is employee of AbbVie and may own AbbVie stock., Katharina Jeromin Shareholder of: Dr. Katharina Jeromin is employee of AbbVie and may own AbbVie stock, Employee of: Dr. Katharina Jeromin is employee of AbbVie and may own AbbVie stock, Carsten Holland Shareholder of: Dr. Carsten Holland is employee of AbbVie and may own AbbVie stock, Employee of: Dr. Carsten Holland is employee of AbbVie and may own AbbVie stock, björn fritz Shareholder of: Dr. Björn Fritz is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Björn Fritz is employee of AbbVie and may own AbbVie stock., Daniela Adolf Consultant of: Dr. Daniela Adolf is an employee of StatConsult GmbH.Statistical analysis was provided under lead of Dr. Daniela Adolf of StatConsult GmbH, which was funded by AbbVie, Peter C. Taylor Speakers bureau: Peter C. Taylor has served as consultant to AbbVie and has received speaker fees from AbbVie, Consultant of: Peter C. Taylor has served as consultant to AbbVie and has received speaker fees from AbbVie, Ralf Baron Speakers bureau: Prof. Ralf Baron has served as consultant to AbbVie and has received speaker fees from AbbVie., Consultant of: Prof. Ralf Baron has served as consultant to AbbVie and has received speaker fees from AbbVie.

ABSTRACT This study aims to analyze the valuation of Islamic banking stocks using the intrinsic value method and the margin of safety Graham number, and determine whether Islamic banking stocks are undervalued or overvalued. This research is included in the descriptive quantitative research. The data source used is secondary data obtained from www.idx.co.id and www.Indopremier.com, while the research sample selection technique uses a purposive sampling method with the criteria of companies that have been IPOs for more than five years and the number of samples found consists of three Islamic banking stocks, namely BRIS, BTPS, and PNBS shares. Based on the results of the valuation of Islamic bank stocks using the intrinsic value method and margin of safety, graham numbers are obtained if the three Islamic bank stocks experience an overvalued/expensive condition above the criteria set by Benjamin Graham, the cause is because investor euphoria is quite high regarding the news of the merger of Bank Syariah Indonesia so that it can be concluded that the three Islamic banking stocks have considerable investment risks. Therefore, investors need to wait and see until the position of the Islamic bank's stock price is close to its fair price. Keywords: Graham Number, Intrinsic Value, Margin of Safety, Market Share, Islamic Banking. ABSTRAK Penelitian ini bertujuan untuk menganalisis valuasi saham perbankan syariah dengan metode intrinsik value dan margin of safety graham number, serta menentukan apakah saham perbankan syariah dalam kondisi undervalue atau overvalue. Penelitian ini termasuk kedalam penelitian kuantitatif deskriptif. Sumber data yang digunakan adalah data sekunder yang diperoleh dari www.idx.co.id dan www.indopremier.com, sedangkan teknik pemilihan sampel penelitian menggunakan metode purposive sampling dengan kriteria perusahaan yang telah IPO lebih dari lima tahun dan diperoleh jumlah sampel yang ditemukan terdiri dari tiga saham perbankan syariah, yakni saham BRIS, BTPS, dan PNBS. Berdasarkan hasil valuasi saham bank syariah dengan menggunakan metode intrinsik value dan margin of safety graham number diperoleh jika ketiga saham bank syariah tersebut mengalami kondisi overvalue/mahal berada diatas kriteria yang ditetapkan oleh Benjamin Graham, penyebabnya dikarenakan euforia investor cukup tinggi mengenai kabar merger Bank Syariah Indonesia sehingga dapat disimpulkan ketiga saham perbankan syariah memiliki risiko investasi yang cukup besar. Maka dari itu, investor perlu wait and see sampai posisi harga saham bank syariah mendekati harga wajarnya. Kata Kunci: Graham Number, Intrinsic Value, Margin of Safety, Market Share, Perbankan Syariah. REFERENCES Alhazami, L. (2020). Valuasi saham yang masih layak untuk dikoleksi di bursa efek Indonesia (BEI) pada Saat pandemik covid-19. Jurnal Ilmiah Akuntansi Dan Keuangan, 9(2), 139–149. https://doi.org/10.32639/jiak.v9i2.526 Antoni, Juwita, R., & Wijayanti, A. P. (2020). Penentuan nilai harga wajar saham menggunakan metode gordon growth model. Co-Value: Jurnal Ekonomi, Koperasi & Kewirausahaan, 11(3), 77–82. Budiman, R. (2020). Investing is easy. PT Elex Media Komputindo. Ervian, P. (2015). Pemanfaatan metode value investing Benjamin Graham untuk meraih capital gain di bursa efek Indonesia. Universitas Kristen Satya Wacana. Graham, B., & Dood, D. L. (2014). Security analysis: Principles and techniques. McGraw Hill. Halim, A. (2005). Analisis investasi. Salemba Empat. Hutabarat, F. (2022). Value investing analysis: A look at Anthony Salim portfolio. 8ISC Proceedings: Business, 58–65. 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Globalization and the Po st-Creole Imagination: Notes on Fleeing the Plantation,by Michaeline A. Crichlow with Patricia Northover (reviewed by Raquel Romberg)Afro-Caribbean Religions: An Introduction to their Historical, Cultural, and Sacred Traditions, by Nathaniel Samuel Murrell (reviewed by James Houk) Africas of the Americas: Beyond the Search for Origins in the Study of Afro-Atlantic Religions, edited by Stephan Palmié (reviewed by Aisha Khan) Òrìṣà Devotion as World Religion: The Globalization of Yorùbá Religious Culture, edited by Jacob K. Olupona & Terry Rey (reviewed by Brian Brazeal) Sacred Spaces and Religious Traditions in Oriente Cuba, by Jualynne E. Dodson (reviewed by Kristina Wirtz) The Coolie Speaks: Chinese Indentured Laborers and African Slaves of Cuba, by Lisa Yun (reviewed by W. Look Lai) Cuba and Western Intellectuals since 1959, by Kepa Artaraz (reviewed by Anthony P. Maingot) Inside El Barrio: A Bottom-Up View of Neighborhood Life in Castro’s Cuba, by Henry Louis Taylor, Jr. (reviewed by Mona Rosendahl) On Location in Cuba: Street Filmmaking During Times of Transition, by Ann Marie Stock (reviewed by Cristina Venegas) Cuba in The Special Period: Culture and Ideology in the 1990s, edited by Ariana Hernandez-Reguant (reviewed by Myrna García-Calderón) The Cubans of Union City: Immigrants and Exiles in a New Jersey Community. Yolanda Prieto (reviewed by Jorge Duany) Target Culebra: How 743 Islanders Took On the Entire U.S. Navy and Won, by Richard D. Copaken (reviewed by Jorge Rodríguez Beruff) The World of the Haitian Revolution, edited by David Patrick Geggus & Norman Fiering (reviewed by Yvonne Fabella) Bon Papa: Haiti’s Golden Years, by Bernard Diederich (reviewed by Robert Fatton, Jr.) 1959: The Year that Inflamed the Caribbean, by Bernard Diederich (reviewed by Landon Yarrington) Dominican Cultures: The Making of a Caribbean Society, edited by Bernardo Vega (reviewed by Anthony R. Stevens-Acevedo) Chanting Down the New Jerusalem: Calypso, Christianity, and Capitalism in the Caribbean, by Francio Guadeloupe (reviewed by Catherine Benoît) Once Jews: Stories of Caribbean Sephardim, by Josette Capriles Goldish (reviewed by Aviva Ben-Ur) Black and White Sands: A Bohemian Life in the Colonial Caribbean, by Elma Napier (reviewed by Peter Hulme) West Indian Slavery and British Abolition, 1783-1807, by David Beck Ryden (reviewed by Justin Roberts) The Children of Africa in the Colonies: Free People of Color in Barbados in the Age of Emancipation, by Melanie J. Newton (reviewed by Olwyn M. Blouet) Friends and Enemies: The Scribal Politics of Post/Colonial Literature, by Chris Bongie (reviewed by Jacqueline Couti) Nationalism and the Formation of Caribbean Literature, by Leah Reade Rosenberg (reviewed by Bénédicte Ledent) Signs of Dissent: Maryse Condé and Postcolonial Criticism, by Dawn Fulton (reviewed by Florence Ramond Jurney) The Archaeology of the Caribbean, by Samuel M. Wilson (reviewed by Frederick H. Smith) Crossing the Borders: New Methods and Techniques in the Study of Archaeological Materials from the Caribbean, edited by Corinne L. Hofman, Menno L.P. Hoogland & Annelou L. van Gijn (reviewed by Mark Kostro)

-Alan L. Karras, Lauren A. Benton, Law and colonial cultures: Legal regimes in world history, 1400-1900. Cambridge: Cambridge University Press, 2002. xiii + 285 pp.-Sidney W. Mintz, Douglass Sullivan-González ,The South and the Caribbean. Jackson: University Press of Mississippi, 2001. xii + 208 pp., Charles Reagan Wilson (eds)-John Collins, Peter Redfield, Space in the tropics: From convicts to rockets in French Guiana. Berkeley: University of California Press, 2000. xiii + 345 pp.-Vincent Brown, Keith Q. Warner, On location: Cinema and film in the Anglophone Caribbean. Oxford: Macmillan, 2000. xii + 194 pp.-Ann Marie Stock, Jacqueline Barnitz, Twentieth-century art of Latin America. Austin: University of Texas Press, 2001. 416 pp.-Ineke Phaf, J.J. Oversteegen, Herscheppingen: De wereld van José Maria Capricorne. Emmastad, Curacao: Uitgeverij ICS Nederland/Curacao, 1999. 168 pp.-Halbert Barton, Frances R. Aparicio, Listening to Salsa: Gender, latin popular music, and Puerto Rican cultures. Hanover NH: Wesleyan University Press, 1998. xxi + 290 pp.-Pedro Pérez Sarduy, John M. Kirk ,Culture and the Cuban revolution: Conversations in Havana. Gainesville: University Press of Florida, 2001. xxvi + 188 pp., Leonardo Padura Fuentes (eds)-Luis Martínez-Fernández, Damián J. Fernández, Cuba and the politics of passion. Austin: University of Texas Press, 2000. 192 pp.-Eli Bartra, María de Los Reyes Castillo Bueno, Reyita: The life of a black Cuban woman in the twentieth century. Durham NC: Duke University Press, 2000. 182 pp.-María del Carmen Baerga, Felix V. Matos Rodríguez, Women and urban change in San Juan, Puerto Rico, 1820-1868. Gainesville: University Press of Florida, 1999. xii + 180 pp. [Reissued in 2001 as: Women in San Juan, 1820-1868. Princeton NJ: Markus Weiner Publishers.]-Kevin A. Yelvington, Winston James, Holding aloft the banner of Ethiopa: Caribbean radicalism in early twentieth-century America. New York: Verso, 1998. x + 406 pp.-Jerome Teelucksingh, O. Nigel Bolland, The politics of labour in the British Caribbean: The social origins of authoritarianism and democracy in the labour movement. Kingston: Ian Randle; Princeton NJ: Marcus Weiner, 2001. xxii + 720 pp.-Jay R. Mandle, Randolph B. Persaud, Counter-Hegemony and foreign policy: The dialectics of marginalized and global forces in Jamaica. Albany: State University of New York Press, 2001. xviii + 248 pp.-Patrick Bellegarde-Smith, Mary A. Renda, Taking Haiti: Military occupation and the culture of U.S. imperialism, 1915-1940. Chapel Hill: University of North Carolina Press, 2001. xvi + 414 pp.-James W. St. G. Walker, Maureen G. Elgersman, Unyielding spirits: Black women and slavery in early Canada and Jamaica. New York: Garland, 1999. xvii + 188 pp.-Madhavi Kale, David Hollett, Passage from India to El Dorado: Guyana and the great migration. Madison NJ: Fairleigh Dickinson University Press, 1999. 325 pp.-Karen S. Dhanda, Linda Peake ,Gender, ethnicity and place: Women and identities in Guyana. London: Routledge, 1999. xii + 228 pp., D. Alissa Trotz (eds)-Karen S. Dhanda, Moses Nagamootoo, Hendree's cure: Scenes from Madrasi life in a new world. Leeds, UK: Peepal Tree, 2000. 149 pp.-Stephen D. Glazier, Hemchand Gossai ,Religion, culture, and tradition in the Caribbean., Nathaniel Samuel Murrell (eds)-Michiel van Kempen, A. James Arnold, A history of literature in the Caribbean. Volume 2: English- and Dutch- speaking regions. (Vera M. Kuzinski & Ineke Phaf-Rheinberger, sub-eds.).Amsterdam/Philadelphia: John Benjamins, 2001. ix + 672 pp.-Frank Birbalsingh, Bruce King, Derek Walcott: A Caribbean life. New York: Oxford University Press, 2000. ix + 714 pp.-Frank Birbalsingh, Paula Burnett, Derek Walcott: Politics and poetics. Gainesville: University Press of Florida, 2001. xiii + 380 pp.-Jeanne Garane, Micheline Rice-Maximin, Karukéra: Présence littéraire de la Guadeloupe. New York: Peter Lang, 1998. x + 197 pp.-Jeanne Garane, Marie-Christine Rochmann, L'esclave fugitif dans la littérature antillaise: Sur la déclive du morne. Paris: Karthala, 2000. 408 pp.-Alasdair Pettinger, Lizabeth Paravisini-Gebert ,Women at sea: Travel writing and the margins of Caribbean discourse. New York: Palgrave, 2001. x + 301 pp., Ivette Romero-Cesareo (eds)

BackgroundGuselkumab (GUS) demonstrated efficacy and a favorable safety profile in active PsA in the Phase (Ph) 21 and Ph3 DISCOVER-1&2 trials2,3 and in moderate-to-severe plaque psoriasis (PsO) in the Ph3 VOYAGE-1&2 trials.4,5ObjectivesTo assess long-term safety of GUS across PsA/PsO trials.MethodsUsing pooled safety data through 2 years (yrs) from PsA trials (N=1229; GUS 100 mg every 4/8 weeks [Q4W/Q8W])1-3 and through 5 yrs from PsO trials (N=1721; GUS 100 mg Q8W),4,5 incidences of serious adverse events (SAEs); gastrointestinal (GI)-related SAEs and other targeted AEs; including candidiasis, uveitis, and opportunistic infections (OIs) were evaluated. Incidence rates (IRs) were calculated as the number of events per 100 pt-yrs (PY) of follow-up with 95% CI. Patients (pts) with an IBD history were not excluded in PsA/PsO trials. Max exposure duration was W100 for PsA trials and W252 for PsO trials.ResultsThe PsA and PsO populations had comparable mean age and BMI. IRs of SAEs and GI-related SAEs were generally similar between GUS- and PBO-treated pts during PBO-controlled periods, and between PsA pts receiving GUS Q4W/Q8W for up to 2 yrs and PsO pts receiving GUS Q8W for up to 5 yrs (Table 1). IRs of other targeted AEs of interest were low. OIs did not occur in PsO pts and were infrequent in PsA pts (Table 1). Candidal infections were infrequent and non-serious. Iridocyclitis was reported in 1 PBO- and 1 GUS Q8W-treated PsA pt. No exacerbations or new onset of IBD or active tuberculosis was reported in GUS-treated PsA/PsO pts.Table 1.Targeted AEs of InterestPooled PsA*Pooled PsOThrough 2 YrsThrough 5 YrsGUS 100 mg Q4W (N=373)GUS 100 mg Q8W (N=475)PBO→GUS 100 mg Q4W (N=352)aPBO→GUS 100 mg Q8W (N=29)aGUS Combined (N=1229)GUS 100 mg Q8W (N=1221)bADA→GUS 100 mg Q8W (N=500)cGUS Combined (N=1721)Total PY645748461171871525419127166Mean PY1.71.61.30.61.54.33.84.2Events/100 PY (95% CI)Overall SAEs4.65(3.14, 6.64)6.42(4.73, 8.51)5.86(3.86, 8.52)0.00(0.00, 17.24)5.61(4.59, 6.79)5.18(4.58, 5.83)4.55(3.64, 5.61)5.01(4.50, 5.56)GI-related SAEs0.46(0.10, 1.36)0.27(0.03, 0.97)0.00 (0.00, 0.65)0.00(0.00, 17.24)0.27(0.09, 0.62)0.44(0.28, 0.66)0.42(0.18, 0.82)0.43(0.29, 0.61)OIsd0.00(0.00, 0.46)0.27(0.03, 0.97)0.22(0.01, 1.21)0.00(0.00, 17.24)0.16(0.03, 0.47)0.00(0.00, 0.06)0.00(0.00, 0.16)0.00(0.00, 0.04)Candida infections0.31(0.04, 1.12)0.00(0.00, 0.40)0.00(0.00, 0.65)0.00(0.00, 17.24)0.11(0.01, 0.39)0.49(0.32, 0.73)0.52(0.25, 0.96)0.50(0.35, 0.70)Non-pathogen specific fungal infections, suspicious for candida0.00(0.00, 0.46)0.27(0.03, 0.97)0.00(0.00, 0.65)0.00(0.00, 17.24)0.11(0.01, 0.39)0.11(0.04, 0.25)0.16(0.03, 0.46)0.13(0.06, 0.24)Uveitis/ Iridocyclitis0.00(0.00, 0.46)0.13(0.00, 0.75)0.00(0.00, 0.65)0.00(0.00, 17.24)0.05(0.00, 0.30)0.00(0.00, 0.06)0.00(0.00, 0.16)0.00(0.00, 0.04)*In PsA Ph2, data after early escape at W16 were excluded. AEs are coded using MedDRA Version 23.1aFor PBO→GUS, data on/after 1st GUS administration were includedbPBO crossover pts were included in GUS column after crossover to GUScEvents prior to GUS (ADA events) were excluded. Only includes pts randomized to ADA at W0 and crossed over to GUS at/after W52 for VOYAGE-1 & W28 for VOYAGE-2dHerpes zoster disseminated, fungal oesophagitis, and meningitis listeria (1 each)ADA=AdalimumabConclusionIRs of SAEs; GI-related SAEs; and AEs of interest including candidiasis, uveitis, and OIs were low, or no cases were reported. No new safety concerns were identified with GUS treatment through 2 yrs and 5 yrs of follow-up in the pooled PsA and PsO trials, respectively, supporting a durable and favorable GUS safety profile consistent between pts with active PsA and moderate-to-severe PsO.References[1]Deodhar A, et al. Lancet. 2018;391:2213-2224.[2]Deodhar A, et al. Lancet. 2020;395:1115-1125.[3]Mease PJ, et al. Lancet. 2020;395:1126-1136.[4]Blauvelt A, et al. J Am Acad Dermatol. 2017;76:405-417.[5]Reich K, et al. J Am Acad Dermatol. 2017;76:418-431.Disclosure of InterestsPhilip J Mease Speakers bureau: AbbVie, Aclaris, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Celgene, Crescendo Bioscience, Genentech, Inmagene, Janssen, Lilly, Merck, Novartis, Pfizer, SUN Pharma, and UCB, Consultant of: AbbVie, Aclaris, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Celgene, Crescendo Bioscience, Genentech, Inmagene, Janssen, Lilly, Merck, Novartis, Pfizer, SUN Pharma, and UCB, Grant/research support from: AbbVie, Aclaris, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Celgene, Crescendo Bioscience, Genentech, Inmagene, Janssen, Lilly, Merck, Novartis, Pfizer, SUN Pharma, and UCB, Peter Foley Speakers bureau: AbbVie, Celgene, Janssen, Eli Lilly, Merck, Novartis, Pfizer, Valeant, Galderma, GlaxoSmithKline, Leo Pharma, and Roche, Paid instructor for: (Advisory boards) AbbVie, Amgen, Aslan, Bristol-Myers Squibb, Boehringer Ingelheim, Celgene, Janssen, Eli Lilly, Merck, Novartis, Pfizer, Sun Pharma, UCB Pharma, Valeant, Galderma, GlaxoSmithKline, Leo Pharma, and Sanofi, Consultant of: Janssen, Eli Lilly, Novartis, Pfizer, UCB Pharma, Bristol-Myers Squibb, Galderma, Leo Pharma, and Roche; investigator for AbbVie, Amgen, AstraZeneca, Arcutis, Aslan, Boehringer Ingelheim, Celgene, Hexima, Janssen, Eli Lilly, Merck, Novartis, Pfizer, Sun Pharma, UCB Pharma, Valeant, Bristol-Myers Squibb, Celtaxsys, CSL, Cutanea, Dermira, Galderma, Genentech, GlaxoSmithKline, Leo Pharma, Regeneron Pharmaceuticals Inc, Reistone, Roche, and Sanofi, Grant/research support from: AbbVie, Amgen, Celgene, Janssen, Leo Pharma, Eli Lilly, Merck, Novartis, Pfizer, Sanofi, and Sun Pharma; travel grants from AbbVie, Janssen, Eli Lilly, Merck, Novartis, Pfizer, Galderma, Leo Pharma, Roche, Sun Pharma, and Sanofi; served as speaker for or received honoraria from AbbVie, Celgene, Janssen, Eli Lilly, Merck, Novartis, Pfizer, Valeant, Galderma, GlaxoSmithKline, Leo Pharma, and Roche, Kristian Reich Speakers bureau: Abbvie, Affibody, Amgen, Biogen, Boehringer Ingelheim Pharma, Bristol Myers Squibb, Celgene, Centocor, Covagen, Eli Lilly, Forward Pharma, Galderma, GlaxoSmithKline, Janssen-Cilag, Leo, Medac, Merck Sharp & Dohme Corp., Novartis, Ocean Pharma, Pfizer, Regeneron, Sanofi, Takeda, UCB Pharma, and Xenoport, Paid instructor for: Abbvie, Affibody, Amgen, Biogen, Boehringer Ingelheim Pharma, Bristol Myers Squibb, Celgene, Centocor, Covagen, Eli Lilly, Forward Pharma, Galderma, GlaxoSmithKline, Janssen-Cilag, Leo, Medac, Merck Sharp & Dohme Corp., Novartis, Ocean Pharma, Pfizer, Regeneron, Sanofi, Takeda, UCB Pharma, and Xenoport, Consultant of: Participated in clinical trials sponsored by Abbvie, Affibody, Amgen, Biogen, Boehringer Ingelheim Pharma, Bristol Myers Squibb, Celgene, Centocor, Covagen, Eli Lilly, Forward Pharma, Galderma, GlaxoSmithKline, Janssen-Cilag, Leo, Medac, Merck Sharp & Dohme Corp., Novartis, Ocean Pharma, Pfizer, Regeneron, Sanofi, Takeda, UCB Pharma, and Xenoport, Soumya D Chakravarty Employee of: Janssen Scientific Affairs, LLC and may own stock or stock options in Johnson & Johnson, May Shawi Employee of: Janssen Global Services, LLC and may own stock or stock options in Johnson & Johnson, Ya-Wen Yang Employee of: Janssen Global Services, LLC and may own stock or stock options in Johnson & Johnson, Megan Miller Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Alexa Kollmeier Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Xie L Xu Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Jenny Yu Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Yanli Wang Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Shihong Sheng Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Yin You Employee of: Janssen Research & Development, LLC and may own stock or stock options in Johnson & Johnson, Iain McInnes Consultant of: AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis and UCB., Grant/research support from: Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, and UCB

A World Among these Islands: Essays on Literature, Race, and National Identity in Antillean America, by Roberto Márquez (reviewed by Peter Hulme) Caribbean Reasonings: The Thought of New World, The Quest for Decolonisation, edited by Brian Meeks & Norman Girvan (reviewed by Cary Fraser) Elusive Origins: The Enlightenment in the Modern Caribbean Historical Imagination, by Paul B. Miller (reviewed by Kerstin Oloff) Caribbean Perspectives on Modernity: Returning Medusa’s Gaze, by Maria Cristina Fumagalli (reviewed by Maureen Shay) Who Abolished Slavery: Slave Revolts and Abolitionism: A Debate with João Pedro Marques, edited by Seymour Drescher & Pieter C. Emmer, and Abolitionism and Imperialism in Britain, Africa, and the Atlantic, edited by Derek R . Peterson (reviewed by Claudius Fergus) The Mediterranean Apprenticeship of British Slavery, by Gustav Ungerer (reviewed by James Walvin) Children in Slavery through the Ages, edited by Gwyn Campbell, Suzanne Miers & Joseph C. Miller (reviewed by Indrani Chatterjee) The Invisible Hook: The Hidden Economics of Pirates, by Peter T. Leeson (reviewed by Kris Lane) Theorizing a Colonial Caribbean-Atlantic Imaginary: Sugar and Obeah, by Keith Sandiford (reviewed by Elaine Savory) Created in the West Indies: Caribbean Perspectives on V.S. Naipaul, edited by Jennifer Rahim & Barbara Lalla (reviewed by Supriya M. Nair) Thiefing Sugar: Eroticism between Women in Caribbean Literature, by Omise’eke Natasha Tinsley (reviewed by Lyndon K. Gill) Haiti Unbound: A Spiralist Challenge to the Postcolonial Canon, by Kaiama L. Glover (reviewed by Asselin Charles) Divergent Dictions: Contemporary Dominican Literature, by Néstor E. Rodríguez (reviewed by Dawn F. Stinchcomb) The Caribbean Short Story: Critical Perspectives, edited by Lucy Evans, Mark McWatt & Emma Smith (reviewed by Leah Rosenberg) Society of the Dead: Quita Manaquita and Palo Praise in Cuba, by Todd Ramón Ochoa (reviewed by Brian Brazeal) El Lector: A History of the Cigar Factory Reader, by Araceli Tinajero (reviewed by Juan José Baldrich) Blazing Cane: Sugar Communities, Class, and State Formation in Cuba, 1868-1959, by Gillian McGillivray (reviewed by Consuelo Naranjo Orovio) The Purposes of Paradise: U.S. Tourism and Empire in Cuba and Hawai’i, by Christine Skwiot (reviewed by Amalia L. Cabezas) A History of the Cuban Revolution, by Aviva Chomsky (reviewed by Michelle Chase) The Cubalogues: Beat Writers in Revolutionary Havana, by Todd F. Tietchen (reviewed by Stephen Fay) The Devil in the Details: Cuban Antislavery Narrative in the Postmodern Age, by Claudette M. Williams (reviewed by Gera Burton) Screening Cuba: Film Criticism as Political Performance during the Cold War, by Hector Amaya (reviewed by Ann Marie Stock) Perceptions of Cuba: Canadian and American Policies in Comparative Perspective, by Lana Wylie (reviewed by Julia Sagebien) Forging Diaspora: Afro-Cubans and African Americans in a World of Empire and Jim Crow, by Frank Andre Guridy (reviewed by Susan Greenbaum) The Irish in the Atlantic World, edited by David T. Gleeson (reviewed by Donald Harman Akenson) The Chinese in Latin America and the Caribbean, edited by Walton Look Lai & Tan Chee-Beng (reviewed by John Kuo Wei Tchen) The Island of One People: An Account of the History of the Jews of Jamaica, by Marilyn Delevante & Anthony Alberga (reviewed by Barry Stiefel) Creole Jews: Negotiating Community in Colonial Suriname, by Wieke Vink (reviewed by Aviva Ben-Ur) Only West Indians: Creole Nationalism in the British West Indies, by F.S.J. Ledgister (reviewed by Jerome Teelucksingh) Cultural DNA: Gender at the Root of Everyday Life in Rural Jamaica, by Diana J. Fox (reviewed by Jean Besson) Women in Grenadian History, 1783-1983, by Nicole Laurine Phillip (reviewed by Bernard Moitt) British-Controlled Trinidad and Venezuela: A History of Economic Interests and Subversions, 1830-1962, by Kelvin Singh (reviewed by Stephen G. Rabe) Export/Import Trends and Economic Development in Trinidad, 1919-1939, by Doddridge H.N. Alleyne (reviewed by Rita Pemberton) Post-Colonial Trinidad: An Ethnographic Journal, by Colin Clarke & Gillian Clarke (reviewed by Patricia van Leeuwaarde Moonsammy) Poverty in Haiti: Essays on Underdevelopment and Post Disaster Prospects, by Mats Lundahl (reviewed by Robert Fatton Jr.) From Douglass to Duvalier: U.S. African Americans, Haiti, and Pan Americanism, 1870-1964, by Millery Polyné (reviewed by Brenda Gayle Plummer) Haiti Rising: Haitian History, Culture and the Earthquake of 2010, edited by Martin Munro (reviewed by Jonna Knappenberger) Faith Makes Us Live: Surviving and Thriving in the Haitian Diaspora, by Margarita A. Mooney (reviewed by Rose-Marie Chierici) This Spot of Ground: Spiritual Baptists in Toronto, by Carol B. Duncan (reviewed by James Houk) Interroger les morts: Essai sur le dynamique politique des Noirs marrons ndjuka du Surinam et de la Guyane, by Jean-Yves Parris (reviewed by H.U.E. Thoden van Velzen & W. van Wetering)

Background:To explore the full therapeutic spectrum of a drug it is crucial to consider its potential effectiveness in all diseases. Serendipitous clinical observations have often shown that approved drugs and those in development to be efficacious in indications different to those originally tested for. Traditional approaches to match a drug candidate with possible indications are mostly based on matching drug mechanistic knowledge with disease pathophysiology. Proof-of-concept trials or elaborate pre-clinical studies in animal models do not allow for a broad assessment due to high costs and slow progress. Gene expression changes in patients or animal models represent a good proxy to comprehensively assess both disease and drug effects. Furthermore, this data type can be integrated with a plethora of publicly available data.Objectives:Generation of a novel in silico framework to support the selection and expansion of potential indications which associate with a compound or approved drug. The framework was exemplified by the clinical compound cenerimod, a potent, selective, and orally active sphingosine-1-phosphate receptor 1 modulator (Piali et al., 2017).Methods:A total of ~13’000 public patient gene expression datasets from ~140 diseases were evaluated against cenerimod gene expression data generated in mouse disease models. To improve comparability of studies across platforms and species, computer algorithms (neural networks) were trained and employed to reduce noise within the data sets and improve signal. The predicted response to cenerimod for individual patients was contrasted against clinical patient characteristics.Results:The neural network algorithm efficiently reduced experimental noise and improved sensitivity in the gene expression data. The results predicted cenerimod to be efficacious in several auto-immune diseases foremost SLE. Additionally, focused analysis on individual patients rather than disease cohorts revealed potential determinants predictive of maximal clinical response, with the highest predicted clinical response for cenerimod in patients with severe inflammatory endotype and/or high SLE Disease Activity Index (SLEDAI).Conclusion:Combining preclinical compound data with the wealth of public disease gene expression data, provides great potential to support indication selection. The novel in silico framework identified SLE as a prime potential indication for cenerimod and supported the cenerimod phase 2b clinical trial in patients with SLE (CARE study,NCT03742037).References:[1]Piali, L., Birker-Robaczewska, M., Lescop, C., Froidevaux, S., Schmitz, N., Morrison, K., … Nayler, O. (2017). Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties. Pharmacology Research & Perspectives, 5(6), 1–12.https://doi.org/10.1002/prp2.370Disclosure of Interests:Dominik Hartl Shareholder of: Idorsia shares, Employee of: Idorsia employee, Marcel Keller Shareholder of: Idorsia options/shares, Employee of: Idorsia employee, Axel Klenk Shareholder of: Idorsia option/shares, Employee of: Idorsia employee, Mark Murphy Shareholder of: Idorsia shares and stock options, Employee of: Idorsia employee, Marianne Martinic Shareholder of: Idorsia options/shares, Employee of: Idorsia employee, Gabin Pierlot Shareholder of: Idorsia options/shares, Employee of: Idorsia employee, Peter Groenen Shareholder of: Idorsia options/shares, Employee of: Idorsia employee, Daniel Strasser Shareholder of: Idorsia options/shares, Employee of: Idorsia employee

Storia della nascita e dell'evoluzione del peer-to-peer, da Napster alle criptovalute, seguita da un analisi di come le applicazioni del peer-to-peer (file-sharing e Bitcoin) sono state dipinte da giornali e riviste italiani, nonchè delle diatribe e processi legali correlati a questo modello.

Nella lunga e fortunata carriera di Peter Paul Rubens, un ruolo fondamentale fu determinato dal rapporto che ebbe con gli arciduchi Alberto VII d’Asburgo e l’Infanta Isabella Clara Eugenia, divenuti governatori delle Fiandre meridionali, sotto l’egida del re di Spagna, di cui fu pittore di corte, agente d’arte, consigliere politico e ambasciatore. Tutte queste circostanze costituiscono la premessa fondamentale di questo studio, che ha per obiettivo l’indagine sistematica della produzione rubensiana commissionata dalla corte di Bruxelles durante gli anni di governo di Alberto VII e Isabella di Spagna. In particolare, l’analisi stilistica e iconografica è stata interpretata secondo i criteri di una precisa volontà di propaganda diplomatica volta a supportare le scelte politiche degli arciduchi, legati alla corte spagnola e, quindi, aderenti alla spiritualità controriformistica dettata dalla Chiesa, ma d’altro canto impegnati nella lotta contro i tentativi di conquista territoriale da parte delle rivoltose Fiandre settentrionali, riunite della neonata e indipendente Repubblica delle Provincie Unite. Il rinvenimento di alcuni importanti documenti archivistici ha inoltre contribuito a conoscere meglio un periodo poco noto nella biografia di Rubens, ossia gli anni italiani, chiarificando l’ambiente intellettuale fortemente cattolico frequentato dal pittore fin dagli anni giovanili, che indubbiamente costituì una fondamentale agevolazione per il suo ingresso alla corte fiamminga una volta tornato in patria.

AbstractHow should we analyse experiences as societal phenomena? This chapter develops a historical-theoretical approach by building on the social theory of Peter L. Berger and Thomas Luckmann with Reinhart Koselleck’s temporal structures of experiencing. We first theorize how experiences are socially constructed and how experiences themselves construct the historically changing social reality. Second, we introduce analytic tools for approaching experiences in socio-historical research. The chapter conceptualizes the temporal and spatial structures of experience as layers of experience and scenes of experience, and indicates how they can be traced by exploring the sediments—shared meanings of experience—that are stored in different sign systems in a given historical context.

Abstract Duncan Sandys lobbied for Austin’s section to move back to central London, and on 12 November 1943 the section was renamed the Theatre Intelligence Section [TIS] and given the top floor of Peter Robinson’s department store in Oxford Circus. Here Austin was primarily occupied with processing data from the French Resistance, providing briefing material for commando raids, and considering the possibility of a landing in Norway. He was most concerned, however, with the Arromanches area of the French coast. This had already been chosen as one of the landing sites for D-Day, but there was a serious worry that the beach might rest on a bed of soft peat that would bog down vehicles. Every effort was made to discover whether this was a serious problem, and eventually it was decided that swimmers must be sent to reconnoitre the beach. Austin’s role in this operation is described in detail.

Abstract Peter Dennis N[itchell was born on 29 September 192() in a two-story semi-detached house at H) Rustic Avenue in the middle-class London suburb of Mitcham, Surrey. His fother, Christopher Gibbs Mitchell, was 31 and his mother, Kate Beatrice Dorothy (nee Taplin) Mitchell, was 27. They had married in 1914 just before World War l broke out An older son, Christopher John (Bill) Mitchell, was born in 1916.The Mitchell family was from DorSE&gt;t, but it is not dear how many generations may have lived there or what occupation they followed. Family lore was that they were descended from seventeenth-century French Huguenot immigrants named Nfichelle and the name had beenanglicized to Mitchell. Although some of the family suspect that a few of their ancestors were engaged in smuggling,l Peter Mitchell liked to think that at least some of his forebears had been pirates in the English Channel.2 What is certain is that Peter Mitchell’s grandfather, Christopher Mitchell, was trained as a stone mason but rose to be manager of a quarry in Portland, the Portland Stone Works. Christopher Mitchell was ambitious and an able businessman whose investments included the firm Minimax, which made fire extinguishers and of which he later became director. Probably in the 188ns he moved to Peckham, London, and became a clerk of works employed by the London County Council. His quMrying expertise led to his forming a pMtnership with Matthew Ascot Rowe, who had made his fortune in the United States. The firm Rowe and Mitchell brought granite from quarries in Alderney to London to make road surfacing for the various London boroughs. Christopher Mitchell married Margaret Way of Weymouth and had two sons, Christopher Gibbs Mitchell, born in 1889, and Godfrey Way Mitchell, born in 1891.

Abstract In his fascinating book entitled Against the Gods: The Remarkable Story of Risk, Peter L. Bernstein notes that whatever data we analyze, it will only be an approximation to reality. In the real world, except for games of chance, we never have all the infor­mation we need to achieve certainty about all possible future scenarios. Worst case futures include the potential for massive death and destruction. Unfortunately, hurricane disasters affect nations disproportionately. The poorest countries worry about loss of life, while the richest countries worry about economic costs. Improvements in the understanding of climate science will offer little in the way of benefits to areas with limited resources. Arguably a stronger global economy, bolstered by sound financial institutions creates an environment in which rich nations generously respond to natural disasters elsewhere.

Abstract John Ford (1586---c.1640) was educated at Exeter College Oxford (leaving after one year), and at the Middle Temple, like other contemporaries turning from the law to drama and poetry (Beaumont, Campion, Sir John Davies, Marston). His earliest dramatic works were in collaboration with Dekker, Webster, and Rowley, achieving independence with The Lovers’ Melancholy (1629), ‘ Tis Pity She’ s a Whore (1633), and Perkin Warbeck (1634). Through out his career Ford wrote poetry, including a number of memorial poems: both Fames Memorial! (1606) and Funeral Teares (1606) for the Duke of Devonshire; A Funeral! Elegye (1612) for William Peter (published as ‘ by WS.’ ); A Memorial!, Offered to that man of virtue, Sir Thomas Ove rburie (1616); and ‘ On the best of English Poets, Ben. Jonson, Deceased’ , in Iosonus Virbius (1638). See The Nondramatic Works of John Ford (Binghamton, NY, 1991), ed. L. E. Stock, G.D. Monsarrat, J.M. Kennedy, D. Danielson; and, for the Funeral! Elegye ascription, Brian Vickers, Counterfeiting Shakespeare: The Politics of Attribution (Cambridge University Press, forthcoming).

On the basis of printed materials in Russian, part of the Merezhkovskys’ private library in Paris, a few biographical facts about Zinaida Gippius are specified, alongside dating the foundation of the aforementioned library. Thus, the article contributes to the study of the Russian-language part of D.S. Merezhkovsky and Z.N. Gippius’ Paris library. Of particular value to researchers of Russia abroad as a special phenomenon and Gippius’ works of the émigré period are her notes on the margins, allowing to reconstruct her reflection of certain literary facts. The article also restores the history of some entries in the Merezhkovskys’ home library. The study of library entries allows to clarify and establish the sources Gippius used for a short story about the Men-of-God sect He Has Descended (1907), the articles Bread of Life (1901) and Infatuation (1904) as well as the poems On Faith and Naked Thoughts (1902). On the basis of D.S. Merezhkovsky’s notes important additions to the creative history and interpretation of his novel Peter and Alexis from the Christ and the Antichrist trilogy, as well as the study L. Tolstoy and Dostoevsky, are made. The final conclusion reflects the particular importance of the Merezhkovskys’ library in Paris, its composition and the exact time of its formation for the study of Gippius’ works, considering a small number of her own testimonies about her creative process.