Дисертації з теми "Stimulation cardiaque"
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Anselme-Martin, François. "Stimulation biventriculaire dans l'insuffisance cardiaque réfractaire." Montpellier 1, 2000. http://www.theses.fr/2000MON11082.
Reuter, Sylvain. "La stimulation bi-ventriculaire dans l'insuffisance cardiaque réfractaire : corrélation entre les données cliniques et hémodynamiques sur un suivi de huit mois." Bordeaux 2, 2000. http://www.theses.fr/2000BOR23075.
SRETENOVIC, YASMINA. "Stimulation cardiaque chez l'enfant : a propos de 93 observations." Lille 2, 1992. http://www.theses.fr/1992LIL2M134.
Franchitti, Alexandra. "Analyse et optimisation d’un réseau de stimulation multisite cardiaque." Paris 6, 2012. http://www.theses.fr/2012PA066190.
This paper presents the results of the Analysis and Optimization of a three-dimensional numerical model representing an array of electrodes for the propagation of the action potential evolving in a cardiac pacing. To calculate this potential, we chose the phenomenological model reaction-diffusion type proposed by Aliev-Panfilov. After choosing the parameters of so-called output ones, relevant to describe the physiological basis of the action potential simulated numerically, we determined the input parameters of the Aliev-Panfilov model that can reproduce these output parameters. The direct simulation being realistic, calibrated in both healthy and diseased cases, we moved to the control of a heart disease to improve its behavior by various types of pacemakers: single site, bisite or multisite. The first objective was to determine a realistic cost functional and in accordance with the specifications chosen by a cardiologist. The mathematical resolution of the control problem hasoptimized the placement of electrodes (for multisite) and the current delivered by the electrode, showing, in this context, the most efficient multisite
Inamo, Jocelyn. "La stimulation cardiaque infantile : Centre de Cardio-Pédiatrie de Bordeaux." Bordeaux 2, 1992. http://www.theses.fr/1992BOR23032.
BROS, CHRISTOPHE. "Stimulation cardiaque double chambre : indications, suivi, complications ; adaptation du delai auriculo-ventriculaire." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13809.
ZEHRIR, ABDELKADER. "Suivi a long terme de la stimulation cardiaque au lithium : a propos de 40 patients porteurs de stimulateurs cardiaques alimentes par la pile greatbatch 702." Lille 2, 1990. http://www.theses.fr/1990LIL2M354.
DAMOURETTE, SUTRE VALERIE. "Suivi a long terme de la stimulation cardiaque isotopique : 90 stimulateurs avec un recul maximum de 18 ans." Lille 2, 1992. http://www.theses.fr/1992LIL2M230.
Chaumont, Corentin. "Stimulatiοn permanente du système de cοnductiοn cardiaque : faisabilité, impact électrοmécanique et applicatiοns cliniques hοrs du champ de la resynchrοnisatiοn cardiaque". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR010.
Right ventricular pacing induces inter- and intraventricular dyssynchrony, increasing the long-term risk of heart failure. Permanent conduction system pacing (CSP), either His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), aims to preserve physiological ventricular activation. We have demonstrated the feasibility and safety of CSP in centers initiating their experience with these techniques. A nationwide survey confirmed a decrease in the use of HBP in favor of LBBAP. We investigated the electromechanical impact and demonstrated that LBBAP preserved interventricular and left intraventricular mechanical synchrony in patients with spontaneous narrow QRS. We then focused on the use of these techniques combined with atrioventricular node ablation (AVNA) for non-controlled atrial arrhythmia: HBP was feasible and effective, despite significant technical challenges. In another study comparing HBP and LBBAP in the “ablate and pace” strategy, LBBAP was associated with a reduction in symptomatic AV node reconduction rate without compromising clinical efficacy. CSP is also of major interest in cases of AV conduction disease, especially in patients with an expected high ventricular pacing burden: a score was developed to predict a ventricular pacing rate ≥ 40% in post-TAVI patients undergoing pacemaker implantation. Finally, we explored a potential future indication of CSP: ventricular regularization in patients with permanent atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). We developed a new Holter parameter to measure beat-to-beat irregularity during AF. An experimental model of isolated, perfused, and stimulated rat heart was established to study the hemodynamic impact of ventricular irregularity. Finally, we proposed a randomized study to compare medical treatment versus ventricular rate regularization (CSP + AVNA) in patients with well-controlled permanent AF and HFpEF
Espil, Guillaume. "La stimulation ventriculaire multisite dans l'insuffisance cardiaque évoluée : apport de l'échographie cardiaque et du doppler tissulaire à l'évaluation de l'asynchronisme et de la resynchronisation ventriculaire." Bordeaux 2, 2000. http://www.theses.fr/2000BOR23084.
Laroche, Frédéric. "La stimulation cardiaque definitive chez l'enfant : etude retrospective portant sur 17 ans." Lyon 1, 1989. http://www.theses.fr/1989LYO1M127.
PLAUCHIER, MICHEL. "Indications et resultats de la stimulation cardiaque permanente : bilan d'activite 1987 du centre de stimulation de l'hopital saint joseph a marseille." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20245.
Betoulle, Sylvie. "La stimulation cardiaque transthoracique : a propos de 8 dossiers du samu 86." Poitiers, 1991. http://www.theses.fr/1991POIT1086.
KOENIG, PHILIPPE. "Stimulation cardiaque definitive a la reunion : a propos de 192 primo-implantations." Angers, 1989. http://www.theses.fr/1989ANGE1036.
LELIEVRE, THIERRY. "Determinants individuels du delai auriculo-ventriculaire optimal en stimulation cardiaque double chambre." Rennes 1, 1993. http://www.theses.fr/1993REN1M039.
MIGEOT, JEAN-LOUIS. "Les complications infectieuses de la stimulation cardiaque endocavitaire permanente : a propos de 14 observations." Nancy 1, 1989. http://www.theses.fr/1989NAN11295.
L, Gagnon Léonard. "Système électro-optique pour l'optogénétique cardiaque et l'enregistrement d'ECG." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/68023.
In the past few years, optogenetics was used in research to replace electrical stimulation of neurons by photo-stimulation. Scientists now search a way to extend optogenetics to cardiac research. Many were able to control the heartbeat of rodents using light. These experiments were conducted using wired and cumbersome equiments with electrocardiogram (ECG) recording using electrodes and photo-stimulation using optical fibers. These systems increase tests subjects stress which can induce measurements errors. This master's thesis describes the design of a device answering this problem. The developed system enables cardiac photostimulation and ECG recording wirelessly with an implant and a low power electronic circuit. The device also includes a real-time algorithm to reduce motion artifacts shown in preliminary testing. Finally, the operation of the prototype is demonstrated during in-vivo experiments.
MOLIN, FRANCK. "Dysfonction sinusale chez le greffe cardiaque : presentation d'un nouveau mode de stimulation definitive." Lille 2, 1991. http://www.theses.fr/1991LIL2M081.
MATACCHIONE, ANTOINE. "La stimulation cardiaque post-operatoire : interet d'un pace-maker double-chambre a largeur d'impulsion variable." Angers, 1993. http://www.theses.fr/1993ANGE1131.
SAADOUN, ANGE-MARC. "Contribution a l'etude des criteres de decision dans l'indication de la stimulation cardiaque permanente." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20064.
Simon, Jean-Philippe. "La stimulation cardiaque double-chambre dans le traitement de la cardiomyopathie hypertrophique et obstructive : interets et limites ; a propos de 13 patients." Nancy 1, 1992. http://www.theses.fr/1992NAN11257.
MESSAGER, PASCALE. "De la stimulation cardiaque temporaire non invasive en urgence : dix exemples d'utilisation au centre hospitalier de senlis." Amiens, 1993. http://www.theses.fr/1993AMIEM049.
Mosser, Christine. "Effets physiologiques des stimulations sonores chez les prématurés." Paris 12, 1990. http://www.theses.fr/1990PA120043.
Garrigue, Stéphane. "Stimulation cardiaque définitive double chambre : étude prospective randomisée comparant la stimulation atriale forcée à la propafénone dans la prévention des arythmies auriculaires." Bordeaux 2, 1997. http://www.theses.fr/1997BOR23022.
Chauvin, Michel. "Interactions entre champs electriques et magnetiques et stimulation cardiaque permanente. Risques induits par l'instrumentation biomedicale." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13044.
Thambo, Jean-Benoît. "Asynchronisme, stimulation cardiaque et resynchronisation biventriculaire dans les cardiopathies congénitales : état des lieux, résultats, perspectives." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21818/document.
The number of adults with severe congenital heart disease is constantly growing. At medium to long-term follow up, these patients may present with heart failure or conduction disorders, which may lead to death. The pathophysiology and clinical course of these complications is multi-factorial and may be different from that in patients without congenital heart disease. In normal hearts, electromechanical dyssynchrony is known to induce ventricular remodeling and heart failure. Ventricular asynchrony is also present in a substantial number of adults with congenital heart disease. In this study, we combined animal experiments and clinical studies to investigate: 1) the acute and chronic effect of biventricular resynchronization therapy on cardiac function in an animal model mimicking right ventricular heart failure in Tetralogy of Fallot, as well as in patients with Tetralogy of Fallot; 2) the consequences of conventional ventricular pacing in patients with ‘systemic right ventricle physiology’; 3) the effects of chronic right ventricular pacing in an animal model of the developing heart.We found that: 1) biventricular resynchronization induces significant hemodynamic benefit in the animal model of Tetralogy of Fallot as well as in Fallot patients; 2) ventricular asynchrony induced by conventional ventricular pacing is deleterious to the function of the systemic right ventricle; 3) chronic right ventricular pacing is harmful to the developing (pediatric) heart with normal biventricular anatomy. Cardiac resynchronization therapy is promising as a treatment for heart failure, but may also prevent heart failure. Nowadays, new implantation techniques allow us to implant pacing devices in patients with limited anatomical access due to prior surgery and help to avoid numerous severe complications of conventional pacing therapy
Klug, Didier. "Les infections sur les sondes endocavitaires de stimulation cardiaque permanente : de la physiopathologie à la clinique." Lille 2, 2003. http://www.theses.fr/2003LIL2MT24.
1. In the first part, some new diagnostic criteria for pacemaker-related (PM) infection have been proposed based on a retrospective study on 52 patients. These criteria have been validated in 2 studies derived from a prospective cohort. A- The significance of cutaneous symptoms at PM implantation site was studied by the lead cultures in 132 patients. Colonisation of the leads in 90% of cases indicated that these complications had an infectious origin. Thus, these signs are to be considered as major criteria for the diagnosis of PM-related infection. B- The value of various bacteriological tests has been evaluated in 254 patients hospitalised for suspicion of PM-related infection. Blood cultures were positive in only 18% of the patients allowing the identification of the responsible bacteria within 91% of cases. More than 90 % of the leads were colonized on their full length, and 25% with several bacteria. The lead culture results were not influenced by the clinical presentation. These results were in favour of a common mechanism of infection and showed that several lead segments should be cultured in common practice. 2. In a second part, the prevalence of this complication has been retrospectively defined in 4,476 patients. Young patients with several PM implantations throughout their follow-up had a higher prevalence of infection than the rest of the population (5. 5% versus 1. 25%, p<0. 01). 3. In the third part, the importance of biofilm formation in this pathology has been studied. Strains of S. Epidermidis involved in PM related-infection were comparable to strains involved in catheter infections for the genes involved in the attachment (fbe and atlE) but were comparable to saprophytic strains for the genes ica involved in adhesion
DESCHAMPS, HENRI DOMINIQUE. "Hypersensibilite sino-carotidienne : evolution a moyen et a long terme des patients traites par stimulation cardiaque monochambre ventriculaire (mode v.v.i.)." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF11027.
Hamon, Denis. "Stimulation ventriculaire asservie : comportement du nœud sinusal aux activités de la vie courante : comparaison avec quatre pacemakers usuels, tests simples pour la surveillance et le réglage." Bordeaux 2, 1992. http://www.theses.fr/1992BOR23120.
Leclercq, Christophe. "Hemodynamique et stimulation cardiaque permanente : applications au traitement des dysfonctions ventriculaires (doctorat : biologie et sciences de la sante)." Rennes 1, 2000. http://www.theses.fr/2000REN1B046.
MEZIANE, ABDENOR. "La stimulation cardiaque a frequence adaptable asservie a l'activite physique : suivi a long terme ; a propos de 20 appareillages suivis de 1 a 5 ans." Toulouse 3, 1989. http://www.theses.fr/1989TOU31200.
Mouchonière, Maud. "Effets de l'hypertrophie sur l'adaptation du potentiel d'action cardiaque aux changements de frequence chez l'homme et le rat." Clermont-Ferrand 1, 1994. http://www.theses.fr/1994CLF1MM10.
BRICOUT, MICHEL. "Securite et stimulateur cardiaque : a propos de l'etude in vitro de l'influence de quatre detecteurs de vol dans les magasins sur 35 stimulateurs." Lille 2, 1990. http://www.theses.fr/1990LIL2M347.
Kulik, Jean-François. "Réactions catécholaminergiques à l'effort chez des patients porteurs d'un stimulateur cardiaque : à propos de 7 patients et 4 témoins." Lille 2, 1991. http://www.theses.fr/1991LIL2M009.
Jiang, Cheng. "Modification de la voie de la stimulation des récepteurs β-adrénergiques dans le myocarde des rats Zucker obèses et obèses diabétiques". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066726/document.
The sympathetic nervous system (SNS) has been identified to be progressively activated in many cardiovascular diseases, from different chronic process including hypertension and cardiomyopathy, to congestive heart failure [82,156,412-414]. The hyperactivity of sympathetic nervous system may change the number, function and downstream mechanisms of β-adrenoceptors. Although there is no unified mechanism to interpret those divergent findings, calcium abnormalities has been recognized to be fundamental in the defective systolic function in left ventricle [82]. The intracellular calcium level is directly involved in the interaction of actin and myosin, thus reflects the contractility of muscle. β-adrenergic stimulation can induce the positive inotropic / lusitropic responses via the production of cyclic adenosine monophosphate (cAMP) and the activation of protein kinase A (PKA). Thus calcium transient is increased after phosphorylation of serials targeted proteins (calcium channel, ryanodine receptor, SERCA2a, and troponin). Under the pathophysiological condition, β-adrenergic dysfunction may be a common mechanism of decreased cardiac function. So, we performed experiments about β-adrenoceptor stimulation pathway in two different pathophysiological status, cardiomyopathy of the elderly and metabolic syndrome. The first experiment is conducted within senescent rat. In the senescent heart, diastolic dysfunction and reduced response to β-adrenergic stimulation have been identified, which are associated with the down-regulation of 1- and 2-adrenoceptors, along with the up-regulation of 3-adrenoceptor. [73,415,416] These changes either reduce the cAMP production or facilitate the hydrolysis of cAMP. Meanwhile, a complementary mechanism of the regulation of cAMP has been involved in heart. The multidrug resistance protein 4 (MRP4) plays an important role in the regulation of intracellular cAMP and β-adrenergic stimulated cardiac responses. But the role of MRP4 in the senescent heart has never been studied. Thus, we conducted the experiment to study the MRP4 expression and its influence on β-adrenergic dysfunction in the senescent rat heart. MRP4 was quantified in left ventricular homogenates by Western blotting. The β-adrenergic responses to isoproterenol were investigated in vivo (stress echocardiography) and in vitro (sarcomere shortening and calcium transient of isolated cardiomyocyte by Ionoptix®) in young (3-month age) and senescent (24-month age) rats pretreated or not with MK571, a specific MRP4 inhibitor. As a result, we confirmed that the MRP4 overexpression contributes to the decrease of positive inotropic response to β-adrenoceptor stimulation in the senescent heart
Lu, Xinyue. "Cardiorespiratory Monitoring by Microphone via Tracheal Sounds in the Context of Implanted Phrenic Nerve Stimulation." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTS011.
Introduction: Patients who have an artificial ventilation dependence are usually treated with mechanical ventilation. If their phrenic nerves and diaphragms are still functional, implanted diaphragm pacing (DP) can provide them a more natural respiration. But existing DP systems cannot monitor patient’s induced respiration and stimulate with a current of constant intensity and frequency. Adding adaptive abilities to existing systems would improve the efficiency of the delivered stimulation and could also deliver an alarm in case of an apnea detection. A respiratory monitoring method based on recordings from tracheal sounds by microphone is introduced. This method aims at being ambulatory and non-invasive for all-day long real-time use.Methods: Tracheal sounds were recorded by a microphone inserted into a 3D printed bell-shape support, which was stuck over patient’s neck. Recorded signals were filtered and pre-amplified then saved and processed in a computer. Four protocols were designed to record and analyze respiration in different contexts: (1) 15 healthy subjects; (2) 1 patient with high tetraplegia under IT-PNS; (3) 13 healthy subjects in sitting and lying positions with reference signals; (4) 30 patients with sleep apnoea and 10 patients with implanted IT-PNS will be included in short future. One real-time processing algorithm detected all inspiration/expiration phases by combining results from temporal envelope detection, frequency detection, and also PDR detection (PCG-derived respiration: variation of cardiac peak amplitude corresponds to respiration). Combining the detection results in these 3 domains allowed for a better specificity of system (less false positives).Results: The application of the algorithms to protocols 1 to 3 data lead to good detection results that met the minimum requirements for the system. These result also showed that noises like speech or environments and different body position do not influence much the detection results. The new proposed respiratory effort evaluation method -- PDR showed a good correlation with EDR, this demonstrates the feasibility to use the PDR to monitor respiration. At a good correlation between R-R intervals and S-S intervals also showed that it would also be possible to monitor heart activity from tracheal sounds.Conclusions: This thesis shows the feasibility of detecting the apnoea and of monitoring cardiac activity from tracheal sounds. The extracted signal PDR could be used to identify the type of apnoea (obstructive/central). Furthermore, the microphone-based recording system could capture stimulation signals which can indicate a dysfunction of the pacing system and recorded tracheal sounds could give a feedback of the electro-ventilation quality. The next step is to record patient's tracheal sounds signals and test if the same algorithm could still work well in this context (the protocol 4).Monitoring tracheal sounds could provide a non-invasive way to approximate inspiratory flow that would be useful in all patients requiring respiratory monitoring in acute situations (e.g. as a safety measure during the administration of morphine for acute pain) and in chronic situations (e.g. home mechanical ventilation). And in the construction of smart house, especially for nursing/retirement home, application of tracheal sounds monitoring could provide convenient, robust multi-vital signals monitoring
Bos, Romain. "Etude du rôle du système rénine angiotensine aldostérone dans la constitution de la fibrose myocardique induite par la stimulation des récepteurs béta-adrénergiques au cours de l'insuffisance cardiaque expérimentale chez le rat." Paris 5, 2004. http://www.theses.fr/2004PA05P619.
The aim of this thesis was to evaluate the effect of the activation of renin angiotensin aldosterone system in cardiac fibrosis induced by beta-adrenergic stimulation. Different studies were performed in rat using different ways of stimulation of cardiac beta-adrenergic receptors and different antagonists of receptors of angiotensin II and aldosterone. Stimulation of beta-adrenergic receptors induced the formation of cardiac fibrosis by a production of adrenal aldosterone. These results showed a strong inter-relationship between sympathetic and renin angiotensin aldosterone systems, which lead to formation of cardiac fibrosis, associated to troubles of cardiac rhythm and to an aggravation of left ventricular function in patients with heart failure. This thesis showed the strong interest to test in a clinical study the early administration of an association of beta-blockers and antagonist of aldosterone in heart failure
Briand-David, Véronique. "Etude des effest inotropes négatifs des inhibiteurs du canal calcique lent sur la cellule cardiaque d'embryon de poulet en culture : modulation par la stimulation beta adrénergique." Tours, 1989. http://www.theses.fr/1989TOUR3301.
Robinot, Alexandre. "Etude physiologique du syndrome d’apnées à composante centrale de l’adulte, hors insuffisance cardiaque à fraction d’éjection systolique altérée." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/ROBINOT_Alexandre_va.pdf.
Pathophysiology of obstructive and central sleep apnea is often dichotomized between obstructive sleep and central apnea, the first is associated with obstruction of upper airways, whereas central sleep apnea is the result of abnormalities of ventilatory control. We hypothesize that, in the central sleep apnea, there are phenotypic features common to obstructive apnea, both in terms of sympathovagal balance and abnormalities in the control of the upper airways, suggesting a pathophysiological continuum between these two types of apnea. In addition, we hypothesize that the respiratory neural network involved in central sleep apnea is different from control subjects but possibly shared with the one of obstructive apnea. To date, only healthy subjects have been studied within the time allotted for this PhD work with regard to this last component.Our results suggestedIn terms of respiratory neural network, in the healthy subject, the insula is the region of interest that has the most gamma 2 oscillations during respiration and communicates at a high frequency level with other regions of interests. The thalamus has a strong coherence with the sensory cortex. Further developments of this work will allow comparison between apneic patients and control, and between central and obstructive apneic patients. Noteworthy we already have a comparison groups of chronic obstructive pneumopathy disease, that will allow comparison between two respiratory pathologies of completely different mechanisms.An increase in the sympathovagal balance in REM sleep compared to slow wave sleep in controls and obstructive SAS, not observed in central SAS, together with a tendency to its decrease during REM in central SAS compared to controls, suggesting a different activation of the autonomic nervous systemPcrit measurements have not been conducted yet, but complete experimental bench is now designed, recruitment of first patients is planed for last trimester 2019. between the slow wave sleep and rapid eyes movements of patients with central and obstructives apneas and the control group.To date our data are too scarce to allow conclusions regarding common pathophysiological pathways between central and obstructive apnea, but our work during this PhD have permitted to get all technical requirement to further address tis question. In addition we propose an innovative approach, using the neural network mapping to describe specificities, if any, of the integrated neural respiratory network in apneic patients, both obstructive and central, vs controls
Alvear-Perez, Rodrigo. "Voies de signalisation activées lors de la stimulation du récepteur de l'apéline, responsables de l'effet hypotenseur de l'apéline." Electronic Thesis or Diss., Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB021.
Apeline is a vasoactive neuropeptide which plays a crucial role in maintaining water balance and cardiovascular functions. Laboratory studies on the effects of Aperlin-17 (K17F) and the K16P apelin fragment, corresponding to K17F deletion from phenylalanine (Phe) at its C-terminal part have shown the presence of this Phe is necessary for apelin to induce internalization of the Apelin receptor. Also cause a decrease in blood pressure. Subsequently, in the CHO cells expressing stably the murine receptor of the Apelin that the internalization of the Apelin receptor induced by K17F resulted in the activation of a second signaling pathway which is independent of the Gi protein, but dependent on beta-arrestin. This corresponds to the MAP kinase pathway (Mitogen Activator Protein Kinase), which could be involved in the hypotensive effect of the Apelin. My work consisted of characterizing a physiological model such as the rat kidney juxtamedullary afferent arterioles (JMAA), to study if the signaling pathway mediated by beta-arrestin was involved in the vasodilatory effect of K17F. Knowing that AngII induces vasoconstriction by increasing intracellular calcium mobilization ([Ca2+]i), we have showed by measuring variations in arteriolar diameter and [Ca2+]i, that when the Gi signaling pathway is blocked by pertussis toxin (PTX), the vasorelaxant effect induced by K17F is not modify. This data suggests that the vasorelaxing effect of K17F on AngII pre-contracted JMAAs is Gi-independent protein. In the presence of PTX and various internalization inhibitors the vasorelaxant effect induced by K17F on AngII-pre-contracted JMAAs is completely blocked. In addition, no significant decrease in [Ca2+]i mobilization is observed in the presence of PTX and these inhibitors, when K17F is applied to the plateau phase of the AngII-induced calcium response. This is in line with our hypothesis, that the vasorelaxing effect of K17F is Gi-independent protein and beta-arrestin-dependent. ApelineR is a potential therapeutic target for the treatment of heart failure and water retention. Knowing that the half-life of the aperitif in the bloodstream is approximatly one minute. Another aspect of my thesis was to develop metabolically stable K17F analogues by two different strategies. First, we have substituted each of the residues of the aperitif with its D-series enantiomer or a synthetic amino acid. Secondly, we added a fluoroalkyl chain to the N-terminal end of K17F. These two strategies have enabled us to obtain several compounds, the most active of which are P92 and LIT01-196. These retain pharmacological properties identical to those of K17F and have a plasma half-life significantly higher compared to the endogenous peptide. These two analogues have been shown to be active in vivo with the ability to reduce blood pressure and reduce vasopressin secretion in the blood leading to an increase in aqueous diuresis
Tamarelle-Gigandet, Catherine. "Ablation par la technique de fulguration endocavitaire des voies accessoires : plaidoyer pour une méthode simplifiée à partir de 38 cas suivis de 7 à 83 mois." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2M029.
Haese, Gwénaëlle. "Mise au point et applications à l’eau potable d’une méthode de mesures sensorielles par indicateurs physiologiques." Rennes, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCR0026.
Classical physicochemical and/or sensory methodologies are inadequate to describe the perception of water. Indeed, the taste of water is difficult to describe due to the medium itself which is considered to have no taste or with tastes due to weak concentrations of sapid molecules. The objective of this thesis is to develop an innovative and objective method for measuring perception. In order to achieve this, a protocol adapted to tasting is constructed from physiological measurements that provide access to unconscious reactions from the nervous system in response to gustatory or olfactory stimuli. The objectives of this work were to: (1) review the various methods of physiological measurements; (2) determine the most relevant to the type of stimuli studied; (3) establish a link between the characteristics of interest (intensity, hedonic valence and concentration); (4) predict the perception of tastes and odours of water. In this study, the physiological measures investigated were the EEG, heart rate, electrodermal and skin blood flow responses. In order to evaluate a large spectrum of flavours, the four basic tastes (sweet, salty, acid and bitter) were used at weak concentrations close to the limit of perception, diluted in Evian water (reference water). An application to chlorine tasting has been developed. It showed that it is possible to construct individual sensory spaces of reference based upon the physiological responses, which are stable over time and directly related to the sensory characteristics of the stimuli and to their concentration in water. Finally, the methodology for building sensory spaces adapted to the characterization of the tastes and odours of water enables the construction of a perceptual space typical of a human subject. The prediction potential of this approach has been demonstrated and shows the relevance of the method for sensory evaluation
Chouchou, Florian. "Réactivité du système nerveux autonome à des stimulations aversives au cours du sommeil chez l’homme." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10040.
The aim of this work was to study cardiac autonomic reactivity to aversive stimulations during sleep and the phenomena that could modulate this reactivity. We used time-frequency method of RR intervals variability (or heart rate variability), based on wavelet transform during nociceptive stimulations in healthy subjects and obstructive respiratory events in apnoeic patients. Our first study showed that the cardiac autonomic reactivity to nociceptive stimulations is sympathetically-driven cardiac activation in reaction, and preserved during all sleep stages. Furthermore, albeit cardiac reactivity persisted even in the absence of arousals, it was higher when a cortical arousal followed the noxious stimulus whatever the sleep stages. Our second work showed, in apnoeic patients, that cardiac autonomic reactivity in response to obstructive respiratory events was also dependent on sympathetic reactivity, mainly modulated by arousal process rather than sleep stages or severity of respiratory events. At last, our third work showed that cardiac sympathetic level before nociceptive stimuli or during respiratory events could favour cortical arousal. In conclusion, cardiac sympathetic reactivity in response to aversive stimuli during sleep is preserved during all sleep stages. This sympathetic reactivity is modulated by arousal process rather than sleep stages or severity of respiratory events. Cardiac sympathetic activity during sleep could take part in arousal process, by favouring cortical arousal
Vigneault, Patrick. "La pro-arythmie médicamenteuse : toujours d'actualité." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28610/28610.pdf.
DERUE, LAURENCE. "Endocardites sur electrodes endocavitaires de stimulateurs cardiaques." Reims, 1993. http://www.theses.fr/1993REIMM064.
Xu, Binbin. "Étude de la Dynamique des Ondes Spirales à l'Échelle Cellulaire par Modèles Expérimental et Numérique." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00955873.
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