Готові списки джерел за темами / Stilbenoidi

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Добірка наукової літератури з теми "Stilbenoidi"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Stilbenoidi"

1

Kambiranda, Devaiah, Sheikh Basha, Stephen Stringer, James Obuya, and Janana Snowden. "Multi-year Quantitative Evaluation of Stilbenoids Levels Among Selected Muscadine Grape Cultivars." Molecules 24, no. 5 (March 11, 2019): 981. http://dx.doi.org/10.3390/molecules24050981.

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Анотація:
Stilbenoids such as t-piceid, t-resveratrol, ε-viniferins, and t-pterostilbene can differ significantly among grape cultivars and years due to variation in environmental conditions and subsequent stressors encountered during a year. This study evaluated diverse muscadine grape cultivars for their ability to consistently produce four major stilbenoids such as t-piceid, t-resveratrol, ε-viniferins, and t-pterostilbene irrespective of environmental changes that can impact their production. Berries from forty-two muscadine grape cultivars were collected for three years (2013, 2014, and 2015) to measure stilbenoids. Results showed significant differences in the composition of four stilbenoids among the muscadine cultivars. The highest level of stilbenoids was observed in ‘Fry Seedless’ (270.20 µg/g fresh weight) in each of the three consecutive years tested followed by ‘Pride’ (46.18 µg/g fresh weight) while ‘Doreen’ produced the lowest level of stilbenoids (1.73 µg/g fresh weight). Results demonstrated that certain muscadine grape cultivars consistently produced varied levels of the four major stilbenoids year after year. Based on the total content of stilbenoids, the 42 muscadine cultivars studied were grouped into three categories such as High, Medium and Low stilbenoid-containing cultivars. This information will help establish new vineyards with cultivars that are less prone to variations in environmental conditions and can consistently produce stilbenoid-rich muscadine grape berries with enhanced market value to promote consumer health.
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2

Pawlus, Alison D., Pierre Waffo-Téguo, Jonah Shaver, and Jean-Michel Mérillon. "Stilbenoid chemistry from wine and the genus Vitis, a review." OENO One 46, no. 2 (June 30, 2012): 57. http://dx.doi.org/10.20870/oeno-one.2012.46.2.1512.

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Анотація:
<p style="text-align: justify;">Stilbenoids are of great interest on account of their many promising biological activities, especially in regards to prevention and potential treatment of many chronic diseases associated with aging. The simple stilbenoid monomer, <em>E</em>-resveratrol, has received the most attention due to early<em> in vitro</em> and <em>in vivo</em> biological activities in anti-aging assays. Since <em>Vitis vinifera</em>, primarily in the form of wine, is a major dietary source of these compounds, there is a tremendous amount of research on resveratrol in wine and grapes. Relatively few biological studies have been performed on other stilbenoids from <em>Vitis</em>, primarily due to the lack of commercial sources of many of these compounds. The diverse stilbenoids from this economically important genus are an untapped source of health promoting compounds and because of this, numerous efforts for isolation, identification and quantification of additional stilbenoids have been ongoing. Additionally, due to their role as phytoalexins, stilbenoids play an important role in the defense against pathogens. Therefore, the compounds produced by highly resistant strains are of great interest for the development of resistant crops, natural spray reagents, and as new dietary supplements or pharmaceuticals. Since closely related species are likely to have similar metabolic pathways, a more thorough understanding of the chemical diversity of stilbenoids within <em>Vitis</em> is useful in this endeavor. In this review, we focus on stilbenoids found in the <em>Vitis</em> genus with the aim of aiding future stilbenoid chemistry, particularly in <em>V. vinifera</em> and wine. Additionally, we discuss the efforts to quantify stilbenoids in <em>Vitis</em>, with a focus on non-resveratrol stilbenoid compounds.</p>
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3

Gajurel, Gaurav, Rokib Hasan, and Fabricio Medina-Bolivar. "Antioxidant Assessment of Prenylated Stilbenoid-Rich Extracts from Elicited Hairy Root Cultures of Three Cultivars of Peanut (Arachis hypogaea)." Molecules 26, no. 22 (November 10, 2021): 6778. http://dx.doi.org/10.3390/molecules26226778.

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Анотація:
Peanut produces prenylated stilbenoids upon biotic stress. However, the role of these compounds against oxidative stress have not been thoroughly elucidated. To this end, the antioxidant capacity of extracts enriched in prenylated stilbenoids and derivatives was studied. To produce these extracts, hairy root cultures of peanut cultivars Hull, Tifrunner, and Georgia Green were co-treated with methyl jasmonate, cyclodextrin, hydrogen peroxide, and magnesium chloride and then the stilbenoids were extracted from the culture medium. Among the three cultivars, higher levels of the stilbenoid derivatives arachidin-1 and arachidin-6 were detected in cultivar Tifrunner. Upon reaction with 2,2-diphenyl-1picrylhydrazyl, extracts from cultivar Tifrunner showed the highest antioxidant capacity with an IC50 of 6.004 µg/mL. Furthermore, these extracts had significantly higher antioxidant capacity at 6.25 µg/mL and 3.125 µg/mL when compared to extracts from cultivars Hull and Georgia Green. The stilbenoid-rich extracts from peanut hairy roots show high antioxidant capacity and merit further study as potential nutraceuticals to promote human health.
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4

Chai, Yuan-yuan, Fang Wang, Yan-li Li, Ke Liu, and Hui Xu. "Antioxidant Activities of Stilbenoids fromRheum emodiWall." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/603678.

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Анотація:
Rheum emodiWall has been reported to possess protective effect in many inflammatory diseases and oxidative stress-related injuries. This study aims to investigate antioxidant power of stilbenoids fromR. emodiand then explore the material basis for its antioxidant potential. The most abundant stilbenoid piceatannol-4′-O-β-D-glucopyranoside (PICG) and its aglycon piceatannol (PICE) were isolated fromR. emodirhizome. Using well-accepted antioxidant chemicals as reference, antioxidant activity of these stilbenoids was examined by measuring DPPH and superoxide anion radical scavenging, ferric reducing power, and inhibition of lipid peroxidationin vitro. Both PICG and PICE displayed promising antioxidant activity in all the four assays. Comparisons among the tested compounds indicated that PICE has the most potent antioxidant activity and the presence of 3′-hydroxyl group may enhance antioxidant activity of stilbenoids. The antioxidative effect of PICE at the cellular level was further demonstrated on the model of hydrogen-peroxide-induced H9c2 rat cardiomyoblasts injury. Taking into account the rapidin vivometabolic transformation of PICG into PICE it can be inferred that the most abundant stilbenoid PICG may be an important constituent responsible for the antioxidant potential ofR. emodiand promising to be developed as an antioxidant agent for supplementary or therapeutic use.
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5

Rathore, Rajendra, and Jay K. Kochi. "Vicinal-diaryl interactions in stilbenoid hydrocarbons as observed in the through-space charge delocalization of their cation radicals." Canadian Journal of Chemistry 77, no. 5-6 (June 1, 1999): 913–21. http://dx.doi.org/10.1139/v99-081.

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Анотація:
The conformational preference of vicinal or 1,2-phenyl groups is probed in two classes of ring-substituted 1,2-diphenylbicyclooctene (stilbenoid) hydrocarbons 1a-1d and 2a-2c. UV-vis spectroscopy reveals, and X-ray crystallography verifies, the intramolecular (edge-to-face) orientation for the phenyl-phenyl interaction in stilbenoids 1a-1d. Most importantly, when two pairs of ortho-methyl substituents are present, the cofacial phenyl groups in the stilbenoid donors are established by X-ray crystallography and spectrally observed in the cation radicals (2a+.-2c+.) by the appearance of new bands with strong absorptions in the near IR with λmax = 1100-1315 nm, analogous to those previously observed in intermolecular (aromatic) interactions of aromatic cation radicals.Key words: stilbenoid hydrocarbon, cation radical, aryl-aryl interaction.
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6

Billet, Kévin, Magdalena Anna Malinowska, Thibaut Munsch, Marianne Unlubayir, Sophie Adler, Guillaume Delanoue, and Arnaud Lanoue. "Semi-Targeted Metabolomics to Validate Biomarkers of Grape Downy Mildew Infection Under Field Conditions." Plants 9, no. 8 (August 10, 2020): 1008. http://dx.doi.org/10.3390/plants9081008.

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Анотація:
Grape downy mildew is a devastating disease worldwide and new molecular phenotyping tools are required to detect metabolic changes associated to plant disease symptoms. In this purpose, we used UPLC-DAD-MS-based semi-targeted metabolomics to screen downy mildew symptomatic leaves that expressed oil spots (6 dpi, days post-infection) and necrotic lesions (15 dpi) under natural infections in the field. Leaf extract analyses enabled the identification of 47 metabolites belonging to the primary metabolism including 6 amino acids and 1 organic acid, as well as an important diversity of specialized metabolites including 9 flavonols, 11 flavan-3-ols, 3 phenolic acids, and stilbenoids with various degree of polymerization (DP) including 4 stilbenoids DP1, 8 stilbenoids DP2, and 4 stilbenoids DP3. Principal component analysis (PCA) was applied as unsupervised multivariate statistical analysis method to reveal metabolic variables that were affected by the infection status. Univariate and multivariate statistics revealed 33 and 27 metabolites as relevant infection biomarkers at 6 and 15 dpi, respectively. Correlation-based networks highlighted a general decrease of flavonoid-related metabolites, whereas stilbenoid DP1 and DP2 concentrations increased upon downy mildew infection. Stilbenoids DP3 were identified only in necrotic lesions representing late biomarkers of downy mildew infection.
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7

Ball, Judith M., Fabricio Medina-Bolivar, Katelyn Defrates, Emily Hambleton, Megan E. Hurlburt, Lingling Fang, Tianhong Yang, et al. "Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis." Advances in Virology 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/293524.

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Анотація:
Rotavirus (RV) infections cause severe diarrhea in infants and young children worldwide. Vaccines are available but cost prohibitive for many countries and only reduce severe symptoms. Vaccinated infants continue to shed infectious particles, and studies show decreased efficacy of the RV vaccines in tropical and subtropical countries where they are needed most. Continuing surveillance for new RV strains, assessment of vaccine efficacy, and development of cost effective antiviral drugs remain an important aspect of RV studies. This study was to determine the efficacy of antioxidant and anti-inflammatory stilbenoids to inhibit RV replication. Peanut (A. hypogaea) hairy root cultures were induced to produce stilbenoids, which were purified by high performance countercurrent chromatography (HPCCC) and analyzed by HPLC. HT29.f8 cells were infected with RV in the presence stilbenoids. Cell viability counts showed no cytotoxic effects on HT29.f8 cells. Viral infectivity titers were calculated and comparatively assessed to determine the effects of stilbenoid treatments. Two stilbenoids, trans-arachidin-1 and trans-arachidin-3, show a significant decrease in RV infectivity titers. Western blot analyses performed on the infected cell lysates complemented the infectivity titrations and indicated a significant decrease in viral replication. These studies show the therapeutic potential of the stilbenoids against RV replication.
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8

Böhme, Thomas, Mari Egeland, Marianne Lorentzen, Mohamed F. Mady, Michelle F. Solbakk, Krister S. Sæbø, and Kåre B. Jørgensen. "Regiospecific Photochemical Synthesis of Methylchrysenes." Molecules 28, no. 1 (December 28, 2022): 237. http://dx.doi.org/10.3390/molecules28010237.

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Анотація:
Methylated polycyclic aromatic hydrocarbons (PAHs) are suspected to be some of the toxic compounds in crude oil towards marine life and are needed as single compounds for environmental studies. 1-, 3- and 6-methylchrysene (3a,b,c) were prepared as single isomers by photochemical cyclization of the corresponding stilbenoids in the Mallory reaction using stoichiometric amounts of iodine in 82-88% yield. 2-methylchrysene (3d) was prepared by photochemical cyclization where the regioselectivity was controlled by elimination of an ortho-methoxy group under acidic oxygen free conditions in 72% yield. These conditions failed to form 4-methylchrysene from the corresponding stilbenoid. All stilbenoids were made from a common naphthyl Wittig salt and suitably substituted benzaldehydes. We have also demonstrated that methylchrysenes can be oxidized to the corresponding chrysenecarboxylic acids by KMnO4 in modest yields.
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9

Mattio, Luce Micaela, Giorgia Catinella, Sabrina Dallavalle, and Andrea Pinto. "Stilbenoids: A Natural Arsenal against Bacterial Pathogens." Antibiotics 9, no. 6 (June 18, 2020): 336. http://dx.doi.org/10.3390/antibiotics9060336.

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Анотація:
The escalating emergence of resistant bacterial strains is one of the most important threats to human health. With the increasing incidence of multi-drugs infections, there is an urgent need to restock our antibiotic arsenal. Natural products are an invaluable source of inspiration in drug design and development. One of the most widely distributed groups of natural products in the plant kingdom is represented by stilbenoids. Stilbenoids are synthesised by plants as means of protection against pathogens, whereby the potential antimicrobial activity of this class of natural compounds has attracted great interest in the last years. The purpose of this review is to provide an overview of recent achievements in the study of stilbenoids as antimicrobial agents, with particular emphasis on the sources, chemical structures, and the mechanism of action of the most promising natural compounds. Attention has been paid to the main structure modifications on the stilbenoid core that have expanded the antimicrobial activity with respect to the parent natural compounds, opening the possibility of their further development. The collected results highlight the therapeutic versatility of natural and synthetic resveratrol derivatives and provide a prospective insight into their potential development as antimicrobial agents.
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10

Pilati, Stefania, Giulia Malacarne, David Navarro-Payá, Gabriele Tomè, Laura Riscica, Valter Cavecchia, José Tomás Matus, Claudio Moser, and Enrico Blanzieri. "Vitis OneGenE: A Causality-Based Approach to Generate Gene Networks in Vitis vinifera Sheds Light on the Laccase and Dirigent Gene Families." Biomolecules 11, no. 12 (November 23, 2021): 1744. http://dx.doi.org/10.3390/biom11121744.

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Анотація:
The abundance of transcriptomic data and the development of causal inference methods have paved the way for gene network analyses in grapevine. Vitis OneGenE is a transcriptomic data mining tool that finds direct correlations between genes, thus producing association networks. As a proof of concept, the stilbene synthase gene regulatory network obtained with OneGenE has been compared with published co-expression analysis and experimental data, including cistrome data for MYB stilbenoid regulators. As a case study, the two secondary metabolism pathways of stilbenoids and lignin synthesis were explored. Several isoforms of laccase, peroxidase, and dirigent protein genes, putatively involved in the final oxidative oligomerization steps, were identified as specifically belonging to either one of these pathways. Manual curation of the predicted sequences exploiting the last available genome assembly, and the integration of phylogenetic and OneGenE analyses, identified a group of laccases exclusively present in grapevine and related to stilbenoids. Here we show how network analysis by OneGenE can accelerate knowledge discovery by suggesting new candidates for functional characterization and application in breeding programs.
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Більше джерел

Дисертації з теми "Stilbenoidi"

1

Holst, Hans Christof. "Stilbenoide Sternsysteme Synthese und Eigenschaften /." [S.l. : s.n.], 2003. http://ArchiMeD.uni-mainz.de/pub/2003/0031/diss.pdf.

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2

Soomro, Shahid A. "Design, synthesis and photochemical studies of stilbenoid dendrimers." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975958569.

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3

Moss, Ryan Kurtis. "Development and validation of methods for the investigation of wine stilbenoids." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50808.

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Анотація:
Stilbenoids are secondary plant metabolites responsible for the protection of grape vine from bacterial and fungal infection. Red wine has been shown to be a major source of these compounds in the human diet, where they display an array of health benefits. The first goal of our study was to develop and validate a robust and selective method for quantification of the major stilbenoids in red and white wine using ultra-high-performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF). Both isomers of resveratrol and piceid were quantified externally using authentic standards, while piceatannol was quantified in trans-piceid equivalents. Due to the minimal amount of sample preparation and the short method runtime, results were obtained rapidly and with low expenditure of energy, chemicals, and labor. The method was validated with respect to linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, intra- and inter-day precision and stability. All six stilbene monomers were quantified in 44 British Columbian wines; the highest total stilbene concentration in an individual wine was 28.81 mg/L in Pinot Noir, while the average across all wines was 8.49 ± 6.25 mg/L.. Another method was developed for separation, identification and semi-quantification of all derivatives of resveratrol that are present in wine. A total of 41 (both known and novel) stilbenoids were detected in extracted red wine. In addition to the well-known monomeric stilbenes, several resveratrol-resveratrol homodimers (m/z 453.1344), resveratrol-piceatannol heterodimers (m/z 469.1293) and piceatannolpiceatannol homodimers (m/z 485.1236) were detected. Modified dimers of resveratrol were also detected. Multiple trimers of resveratrol (m/z 679.1978) were detected for the first time in red wine, as well as some known and some novel stilbenoid tetramers (m/z 905.2604). A solid-phase extraction (SPE) method was developed for quantification of the stilbenoid oligomers in red wines. The monomers and oligomers in red wine from the Okanagan Valley (Cabernet Sauvignon, Merlot and Pinot Noir) and Québec (Maréchal Foch, Marquette, Sabrevois, St.Croix, and Frontenac) wines were semi-quantified as using this method. The highest concentration of total stilbenoids was 10.67 mg/L in Pinot Noir with an overall average of 3.32 ± 2.86 mg/L in all wines.
Irving K. Barber School of Arts and Sciences (Okanagan)
Chemistry, Department of (Okanagan)
Graduate
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4

Ressler, Daniel. "Synthesis of Resveratrol Ester Derivatives." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1234.

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Анотація:
The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water solubility of the resveratrol derivative. This brought the research closer to the goal of determining how this would affect the binding ability to HSA. Currently three derivatives have been synthesized and purified once by column chromatography.
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5

Karpouk, Elena. "Photochemie von ungesättigten Sternverbindungen Wirt-Gast-Systeme bei stilbenoiden Dendrimeren /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971998450.

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6

Bhusaunahalli, Vedamurthy Maheswarappa. "Natural polyphenols as lead compounds in the synthesis of antitumor agents and other useful products." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/961.

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Анотація:
NATURAL POLYPHENOLS AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS Abstract Some polyphenol dimers, such as lignans, neolignans and stilbenoid lignans, because of their biological properties as well as their structural variety, are an attractive target for chemical synthesis or modification. These polyphenols may be considered lead compounds to obtain products with useful properties, for instance as possible antitumor agents. Thus, this three year research work has been oriented to the synthesis of new dimers, obtained by biomimetic oxidative coupling of natural polyphenols belonging to the stilbenoid and phenylpropanoid families, namely resveratrol or caffeic acid analogues. To this purpose we employed both chemical and enzymatic methods; in particular, metal-mediated reactions were used for the synthesis of nitrogenated lignans with a benxanthene core, whereas stilbenolignans were also obtained with laccase-mediated reactions. During this work, an unexpected enzymatic reaction afforded an hydantoin-related product and this result is also reported herein. The results of this research are discussed mainly in chapter 2, where three sections are reported: 1) Biomimetic synthesis of stilbenolignans 2) Biomimetic synthesis of benzo[k,l]xanthene lignanamides 3) Enzymatic synthesis of hydantoin-related compounds In each section, we have reported in detail the synthesis, structural determination, and mechanism of the formation of the products. The final goal of our project was to obtain a library of bioactive compounds to be addressed to biological evaluation with the aim to establish structure-activity relationships for a future optimization of the most promising products. The biological evaluation has been completed for the stilbenolignan group and it is in progress for the other compounds.
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7

Van, Cleve Shelley Marie. "Synthesis of a Resveratrol Glycinate Derivative." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1312.

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Анотація:
Recently, the compound resveratrol has had media attention as an anti carcinogen. However, the bioavailability of resveratrol is low in the human system due to its hydrophobic nature. Therefore, it must be administered in high dosages to be effective. A plethora of derivatives have been synthesized that have the potential of resveratrol but sadly share low bioavailability. The first effort of this research was an attempt to produce a more hydrophilic ester of resveratrol. Failing this, the final product was synthesized using a glycine derivative to produce 4-[(1E)-2-(3,5-diacetyloxyphenyl)ethenyl]phenyl N-[(1,1-dimethylethoxy)carbonyl]-glycinate.
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8

Jing, Stanley Mofor. "Synthesis of Resveratrol Esters and Aliphatic Acids." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1382.

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Анотація:
Resveratrol (RV) is a naturally occurring phytoalexin of the stilbenoid family produced by some plant species, and present in grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, anti-viral, anti-aging, cardio protective, and anti-oxidant properties. Bioavailability is a huge setback that limits the potentials of RV. As a result, efforts have been made to design and synthesize RV esters and aliphatic acids in an attempt to increase its bioavailability, solubility in water, and possibly improving its biological activities. Resveratrol esters, 3,5,4'-triacetyloxystilbene (2) and Methyl 1,1',1''- (3,4',5-stilbenyl)-1,6-hexanedioate (3) have been synthesized. Compound 3 is a new compound, synthetic yield is 88%, and purity is above 95% based on NMR integration. Both 2 and 3 are good candidates for biological evaluation. 3 was used as a precursor in the synthesis of resveratrol aliphatic acid, 8-(3',5'-dihydroxylstilbene-4''-oxy)-3,6-dioxocotanoic acid (9). First, 2 was hydrolyzed to resveratrol diester, 3,5-diacetyloxystilbene (4). Mitsunobu reaction of 4 and methyl 8-hydroxy-3,6-dioxooctanoate (7) was then carried out to afford methyl 8-(3',5'-diacetyoxystilben-4''-oxy)-3.6-dioxooctanoate (/5), which was then hydrolyzed to afford 9 in total 43.6 % yield. Structures of all newly synthesized compounds were confirmed by 1H and 13C NMR spectroscopy.
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9

Bisson, Jonathan. "Développements méthodologiques en chromatographie de partage : application aux stilbénoïdes." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22006/document.

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Анотація:
Les stilbénoïdes, sont des composés phénoliques majoritairement issus du règne végétal. La Vigne par l’intermédiaire du vin et du raisin est la principale source alimentaire de stilbènes. La mise en évidence de leur rôle dans les mécanismes de défense des plantes et leurs activités biologiques, y compris sur l’Homme, en font un sujet d’étude en plein essor. L’un des objectifs de cette thèse a été de développer un ensemble de stratégies à la fois analytiques et préparatives utilisant la Chromatographie de Partage Centrifuge (CPC) pour l’étude et l’obtention de ces molécules. Dans un premier temps, nous avons développé une approche de couplage entre cette technique et un spectromètre à Résonance Magnétique Nucléaire (RMN) par l’intermédiaire d’un système d’Extraction sur Phase Solide automatisé (EPS). Dans un second temps, nous avons mis au point un ensemble de méthodes et d’approches séparatives permettant d’obtenir ces composés. Nous avons, grâce au développement d’une méthodologie de dosage de solvants par spectrométrie RMN, étudié une gamme dérivée d’une gamme très utilisée en CPC, l’ARIZONA. Nous avons montré que ces systèmes dérivés, peuvent être utilisés au travers de stratégies d’élution telles que des pas et des gradients afin d’optimiser les séparations. L’une des finalités de notre travail est d’offrir des méthodes permettant d’obtenir ces composés dans des quantités et des qualités suffisantes pour pouvoir constituer une chimiothèque interne au laboratoire pouvant prétendre à s’intégrer dans la Chimiothèque Nationale. Une dernière partie fait état du développement d’outils informatiques, dont la création d’une base de donnée Libre pour les chercheurs en Substances Naturelles
Stilbenoids are phenolic compounds mostly found in the vegetable kingdom. Vine through wine and grape is the main source of stilbenes in the human diet. The involvement of these compounds in plants resistance mechanisms and their diverse biological activities, including on the human health are continuously highlighted. Making this topic a fast-growing one. One of the objectives of this thesis has been to develop a whole set of analytical and preparative strategies using Centrifugal Partition Chromatography (CPC) in order to study and obtain these molecules. Over a first phase, we developed a hyphenated approach between this technique and Nuclear Magnetic Resonance (NMR) through an automated Solid Phase Extraction (SPE) system. Then, we developed a set of separative methods and approaches with the aim of obtaining these compounds. Then, we carried out the development of a solvent quantifications methodology using NMR spectrometry. This allowed us to study a spin-off scale of a widely-used solvent systems collection called ARIZONA. We showed that these systems are good candidates for different elution strategies using steps and gradients with the aim to optimize separations. One of our purpose was to provide methods for effective and efficient purification of these compounds. This would allow, together with a lab-scale compounds library, their integration into the Chimiothèque Nationale, a nationwide chemical library. Last part accounts for computer tools development, including the creation of a Free database system for Natural Substances researcher
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10

Lambert, Carole. "Étude du rôle des stilbènes dans les défenses de la vigne contre les maladies du bois." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21910/document.

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Анотація:
Les maladies du bois de la vigne, par exemple le syndrome de l’esca et l’eutypiose, sont dues à des champignons qui se développent dans le xylème et dégradent les tissus ligneux. Elles sont en recrudescence depuis une vingtaine d’année dans tous les vignobles du monde. A ce jour, aucun traitement curatif n’est disponible alors que ces maladies engendrent généralement la mort de la plante. L’étude des relations hôte-parasite et notamment celle des réponses de défense de plante, est nécessaire pour la compréhension et le développement de nouvelles stratégies de lutte. Parmi les molécules de défense de la vigne, les stilbènes sont connus pour leur forte activité antifongique.Notre travail, basé sur des approches biochimiques et moléculaires apporte de nouvelles données sur le rôle potentiel des stilbènes en tant que molécules de défense contre les maladies du bois. Nous avons identifié et quantifié les stilbènes majoritaires des tissus ligneux de V. vinifera, évalué la sensibilité des agents de maladie du bois à l’effet antifongique de ces stilbènes et suivi leur éventuelle induction suite à l’inoculation d’agents de maladie du bois. Nous avons souligné l’importance des oligomères de stilbènes dont l’activité antifongique est élevée et montré qu’ils sont fortement induits dans le bois inoculé par un champignon pathogène de la famille des Botryosphaeriaceae. La comparaison des réponses de défenses entre des cépages tolérants et sensible, a montré que les cépages tolérants répondent globalement plus fortement et plus rapidement que le cépage sensible à une élicitation par un filtrat de milieu de culture d’un agent de l’esca
Grapevine wood diseases, as esca syndrome and eutypiosis, are worldwide afflictions. They are due to xylem inhabiting fungi that cause the decay of woody tissues and finally the death of the plant. No curative treatment has been successfully developed until now. Studying grapevine-wood disease pathogen interaction is a prerequisite to the development of protection strategies. Phenolics, particularly stilbenoids, are antimicrobial molecules involved in the resistance of grapevine to fungal pathogens. Our work, based on biochemical and molecular approaches, reveals new data on the possible role of stilbenoids in grapevine defence against trunk diseases. We identified and quantified major stilbenoids of woody canes from V. vinifera. These compounds, especially stilbenoid oligomers, displayed in vitro antifungal activity against trunk disease agents and were induced in cuttings inoculated with an agent of the Botryosphaeriaceae family. We also compared the defence response of susceptible or tolerant cultivars to wood decay based on an elicitation assay with a culture filtrate of an esca pathogen. Defence responses of tolerant cultivars were more effective than those of the susceptible cultivar
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Книги з теми "Stilbenoidi"

1

Motoo, Tori, and Asakawa Yoshinori, eds. The biochemistry of the stilbenoids. London: Chapman & Hall, 1995.

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2

Gorham, J. Biochemistry of the Stilbenoids (Biochemistry of Natural Products, No 1). Springer, 1995.

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Частини книг з теми "Stilbenoidi"

1

Shen, Tao, Chun-Feng Xie, Xiao-Ning Wang, and Hong-Xiang Lou. "Stilbenoids." In Natural Products, 1901–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_63.

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2

Duarte, Noélia, Cátia Ramalhete, Patrícia Rijo, Mariana Alves Reis, and Maria-José U. Ferreira. "Stilbenoids in Grapes and Wine." In Handbook of Dietary Phytochemicals, 1–28. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1745-3_21-1.

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3

Duarte, Noélia, Cátia Ramalhete, Patrícia Rijo, Mariana Alves Reis, and Maria-José U. Ferreira. "Stilbenoids in Grapes and Wine." In Handbook of Dietary Phytochemicals, 1005–32. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-4148-3_21.

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4

Waffo-Téguo, Pierre, Stéphanie Krisa, Alison D. Pawlus, Tristan Richard, Jean-Pierre Monti, and Jean-Michel Mérillon. "Grapevine Stilbenoids: Bioavailability and Neuroprotection." In Natural Products, 2275–309. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_74.

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5

Yang, Tianhong, Lingling Fang, and Fabricio Medina-Bolivar. "Production and Biosynthesis of Bioactive Stilbenoids in Hairy Root Cultures." In Production of Plant Derived Natural Compounds through Hairy Root Culture, 45–64. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-69769-7_3.

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6

Billet, Kevin, Magdalena Anna Malinowska, Thibaut Munsch, Marianne Unlubayir, Thomas Dugé de Bernonville, Sébastien Besseau, Vincent Courdavault, et al. "Stilbenoid-Enriched Grape Cane Extracts for the Biocontrol of Grapevine Diseases." In Progress in Biological Control, 215–39. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51034-3_9.

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7

Gorena, Tamara, Claudia Mardones, Carola Vergara, Vania Saez, and Dietrich von Baer. "Evaluation of the Potential of Grape Canes as a Source of Bioactive Stilbenoids." In ACS Symposium Series, 347–63. Washington, DC: American Chemical Society, 2015. http://dx.doi.org/10.1021/bk-2015-1203.ch022.

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8

Beetch, Megan, and Barbara Stefanska. "DNA Methylation in Anti-cancer Effects of Dietary Catechols and Stilbenoids: An Overview of Underlying Mechanisms." In Handbook of Nutrition, Diet, and Epigenetics, 1819–44. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-55530-0_104.

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9

Beetch, Megan, and Barbara Stefanska. "DNA Methylation in Anti-Cancer Effects of Dietary Catechols and Stilbenoids: An Overview of Underlying Mechanisms." In Handbook of Nutrition, Diet, and Epigenetics, 1–26. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-31143-2_104-1.

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10

Xiao, Kai, Hong-Jun Zhang, Li-Jiang Xuan, Juan Zhang, Ya-Ming Xu, and Dong-Lu Bai. "Stilbenoids: Chemistry and bioactivities." In Bioactive Natural Products (Part N), 453–646. Elsevier, 2008. http://dx.doi.org/10.1016/s1572-5995(08)80032-4.

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Тези доповідей конференцій з теми "Stilbenoidi"

1

Castellano, Gloria, Adela León, and Francisco Torrens. "Quantitative Structure-Antileukemic Activity Models of stilbenoids: A Theoretical Study." In MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/mol2net-04-05903.

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2

Coya, C., A. L. Álvarez, M. Ramos, A. de Andrés, C. Zaldo, R. Gómez, J. L. Segura, and C. Seoane. "A fluorescent stilbenoid dendrimer for solution-processed blue light emitting diodes." In Photonics Europe, edited by Paul L. Heremans, Michele Muccini, and Eric A. Meulenkamp. SPIE, 2008. http://dx.doi.org/10.1117/12.781089.

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3

Kamarozaman, AS, N. Ahmat, MSM Johari, ZZ Hafiz, MI Adenan, and SAS Mohamad. "Isolation of tetramer stilbenoids from Shorea leprosula Miq., acetylcholinesterase inhibitory activity and molecular docking study." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399897.

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4

Stefanska, Barbara, Cayla Boycott, and Tony Yang. "Abstract PO-002: Epigenetic regulation of metabolic pathways in response of breast cancer cells to stilbenoids." In Abstracts: AACR Special Virtual Conference on Epigenetics and Metabolism; October 15-16, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.epimetab20-po-002.

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5

Dávid, ZC, N. Kúsz, D. Stefkó, L. Papp, J. Hohmann, and A. Vasas. "Screening of the antioxidant capacity of Cyperaceae species and isolation of stilbenoids and other phenolic compounds from Carex praecox." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759267.

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6

Hošek, J., V. Leláková, K. Jabubczyk, P. Landa, T. Stammer, V. Temml, D. Schuster та K. Šmejkal. "Influence of the structure of prenylated and non-prenylated stilbenoids on the NF-κB/AP-1 signalling pathway and cyclooxygenases/lipoxygenase inhibition". У GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608324.

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