Статті в журналах: "Sports hub"

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Coche, Roxane, and Benjamin J. Lynn. "Behind the Scenes: COVID-19 Consequences on Broadcast Sports Production." International Journal of Sport Communication 13, no. 3 (September 1, 2020): 484–93. http://dx.doi.org/10.1123/ijsc.2020-0231.

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Live events are central to television production. Live sporting events, in particular, reliably draw big audiences, even though more consumers unsubscribe from cable to stream content on-demand. Traditionally, the mediated production of these sporting events have used technical and production crews working together on-site at the event. But technological advances have created a new production model, allowing the production crew to cover the event from a broadcast production hub, miles away, while the technical crew still works from the event itself. These remote integration model productions have been implemented around the world and across all forms of sports broadcasting, following a push for economic efficiency—fundamental in a capitalist system. This manuscript is a commentary on the effects of the COVID-19 global crisis on sports productions, with a focus on remote integration model productions. More specifically, the authors argue that the number of remote sports productions will grow exponentially faster, due to the pandemic, than they would have under normal economic circumstances. The consequences on sport media education and research are further discussed, and a call for much needed practice-based sports production research is made.

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King, Mike, William Whitby, and Graeme Hanshaw. "Design of the Singapore Sports Hub Roof with High Strength Niobium Steel." IABSE Symposium Report 101, no. 11 (September 1, 2013): 1–8. http://dx.doi.org/10.2749/222137813808627343.

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Lewis, Clive, and Mike King. "Designing the world's largest dome: the National Stadium roof of Singapore Sports Hub." IES Journal Part A: Civil & Structural Engineering 7, no. 3 (July 3, 2014): 127–50. http://dx.doi.org/10.1080/19373260.2014.911485.

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Musselman, Roman C., J. Mark VanNess, Greg Roberts, Jonathan M. Saxe, Lewis E. Jacobson, and Courtney D. Jensen. "The Kidney As A Hub For Ph Modulation." Medicine & Science in Sports & Exercise 50, no. 5S (May 2018): 421. http://dx.doi.org/10.1249/01.mss.0000536473.20098.78.

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Mudiganty, Srikanth, Luke Hughes, Qaisar Choudry, and Awais Bokhari. "Managing periprosthetic fractures – a review of the hub and spoke model." SICOT-J 8 (2022): 2. http://dx.doi.org/10.1051/sicotj/2022001.

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Introduction: Periprosthetic fractures are associated with significant morbidity and mortality. The “hub and spoke model” consists of a central organisation (the hub) and a series of secondary units (the spokes). This study reviews the presentation, management, and outcomes of periprosthetic fractures at a large general district hospital, the Royal Blackburn Hospital. Methods: A retrospective data analysis for patients presenting with periprosthetic fractures from a single general district hospital between January 2011 and December 2020. Details recorded were patient demographics, primary arthroplasty procedure, fracture management, ASA grade, morbidity and mortality, and Unified Classification System for Periprosthetic Fractures (UCSPF). Results: With 229 periprosthetic fractures, the number tripled in 2020 that admitted in 2011. The mean age was 78.6 years (range 33–100), 151 were females. Seventy-five percent of the fractures were managed locally, while 25% a referral to the higher specialist centre was sort. Of the 57 referrals, 50 were transferred to the hub, 5 were operated on locally, and 2 were managed non-operatively. Higher-level care transfer resulted in a delayed definitive treatment (4.8 versus 12 days, p = 0.001). About 94.4% of patients treated locally had a favourable outcome versus 92% of patients treated at the hub hospital. Cumulative mortality rates for the two sites were comparable. Discussion: Most of the patients presenting to the local spoke hospital with periprosthetic fractures were managed in house. For this practice to be preserved, there is a need for future planning, such as maintaining an appropriate skill mix at spoke units. Discussion between specialists at the hub and spoke hospitals reduced patient transfer by 14%.

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Razzaghi, Mohammadreza, Mohammad Rostami-Nejad, Mostafa Rezaei-Taviran, Mona Zamanian Azodi, Farshad Okhovatian, Vahid Mansouri, and Nayebali Ahmadi. "Muscle Recovery Is Highlighted by IR Laser Therapy." Journal of Lasers in Medical Sciences 10, no. 5 (December 1, 2019): S49—S53. http://dx.doi.org/10.15171/jlms.2019.s9.

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Introduction: In sports medicine, laser application has been well-established for the recovery of muscles. The mechanisms by which benefits of this kind of therapy can be studied is molecular research approach. Protein-protein interaction network analysis as one of the important complementary studies of proteomics can accelerate this goal by the identification of novel contributing markers. Methods: By the use of Cytoscape V3.7.1 and its applications, a network of differential expressed proteins (DEPs) from IR laser treatment samples were constructed and analyzed. Six hub-bottlenecks were determined, 4 of which were from differentially expressed proteins. Results: ClueGO discovered 4 biological processes related to these hub-bottlenecks that their function could alter due to IR laser therapy. Conclusion: In fact, by the expression changes of hub-bottlenecks including the up-regulation of HSP90s, one of the prominent biological processes in muscle recovery could be activated. This process is called nitric oxide synthase (NOS) activation that could be proposed as one of the underlying mechanisms of IR laser treatments in muscle recovery.

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Shi, Wei, Xinglong Zhang, Chunlei Xu, Ran Pang, Zhenqi Fan, Xin Wan, Zhaohui Jiang, Hui Li, Zhijun Li, and Huafeng Zhang. "Identification of Hub Genes and Pathways Associated with Oxidative Stress of Cartilage in Osteonecrosis of Femoral Head Using Bioinformatics Analysis." CARTILAGE 13, no. 1 (January 2022): 194760352210740. http://dx.doi.org/10.1177/19476035221074000.

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Objective This study aimed to identify the hub genes and pathways of genes related to oxidative stress of cartilage in osteonecrosis of femoral head (ONFH), and to predict the transcription factors of the hub genes. Methods The GSE74089 was obtained from the Gene Expression Omnibus (GEO) database, including 4 necrotic tissues and 4 normal tissues, and the differentially expressed genes (DEGs) were identified by limma package in R language. Simultaneously, we searched for the genes related to oxidative stress in the Gene Ontology (GO) database. GO and signaling pathways analysis were performed using DAVID, Metascape, and GSEA. Protein-protein interaction (PPI) network was constructed using the STRING database, and the Degree algorithm of Cytoscape software was used to screen for hub genes. Finally, the NetworkAnalyst web tool was used to find the hub genes’ transcriptional factors (TFs). Results In total, 440 oxidative stress–related genes were found in GSE74089 and GO database, and 88 of them were significantly differentially expressed. These genes were mainly involved in several signaling pathways, such as MAPK signaling pathway, PI3K-AKT-mTOR signaling pathway, FOXO signaling pathway. The top 10 hub genes were JUN, FOXO3, CASP3, JAK2, RELA, EZH2, ABL1, PTGS2, FBXW7, MCL1. Besides, TFAP2A, GATA2, SP1, and E2F1 may be the key regulatory factors of hub genes. Conclusions We identified some hub genes and signaling pathways associated with oxidative stress in ONFH through a series of bioinformatics analyses.

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Tony, Yassmin, Aya ElMeligy, Darin Refaat, and Gehan ElSayed. "Community Center as a Cultural Hub, for Cultural Heritage Conservation." Resourceedings 2, no. 2 (September 2, 2019): 144. http://dx.doi.org/10.21625/resourceedings.v2i2.610.

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Community centers are a type of community development services that promote social relationships and mutual support, develop a sense of self-reliance, social responsibility and community cohesion, as well as empowering individuals and families to solve common social problems. In doing so, community centers enhance, one way or another, the community's quality of life. The successful design of community centers ought to accomplish a set of goals in different aspects ;1- Socially, providing a safe place to practice various activities, 2- Environmentally, ensuring a healthy environment through utilizing natural ventilation, lighting, among other passive techniques, 3-Recreational, offering different kinds of entertainment activities, either indoor or outdoor, such as commercial spaces and sports facilities, 4-Economically, attracting different visitors and promoting tourism, 5- Educational, providing a pleasant environment for educational services for the illiterate and children. The importance of the above-mentioned goals is greatly escalated in urban contexts with diverse social, urban and status, as in the case of " Magra Al " district. A rich historical area that has been severely affected by population growth, deteriorated urban state, plethora of social, economical, and environmental problems. The main aim of the research is to provide an overview of the design criteria of community centers taking into consideration the mutual impacts between the design and the surrounding context, focusing on the significant value of " Magra Al " district as one of Cairo's heritage sites, thus ensuring its sustainability.

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Casiraghi, Alessandro, Marco Domenicucci, Stefano Cattaneo, Emanuele Maggini, Fabio Albertini, Stefania Avanzini, Manuela Pansi Marini, Claudio Galante, Pierangelo Guizzi, and Giuseppe Milano. "Operational strategies of a trauma hub in early coronavirus disease 2019 pandemic." International Orthopaedics 44, no. 8 (June 6, 2020): 1511–18. http://dx.doi.org/10.1007/s00264-020-04635-5.

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S. McGinnis, Ryan, and Steven Nesbit. "Golf Club Deflection Characteristics as a Function of the Swing Hub Path." Open Sports Sciences Journal 3, no. 1 (March 7, 2014): 155–64. http://dx.doi.org/10.2174/1875399x01003010155.

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Carver, T. C., A. C. Lim, D. C. Ziewacz, B. M. Turner, A. G. Edwards, and W. C. Byrnes. "A MECHANICAL AND PHYSIOLOGICAL VALIDATION OF A REAR HUB POWER METER FOR CYCLING." Medicine & Science in Sports & Exercise 35, Supplement 1 (May 2003): S17. http://dx.doi.org/10.1097/00005768-200305001-00077.

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Eagle, S. R., M. W. Collins, C. Connaboy, S. D. Flanagan, and A. P. Kontos. "A-15 Network Analysis Of Sport-Related Concussion Research During The Past Decade (2010–2019)." Archives of Clinical Neuropsychology 35, no. 5 (June 18, 2020): 611. http://dx.doi.org/10.1093/arclin/acaa036.15.

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Abstract Objective The purpose of this study was to apply network analyses to evaluate trends in the literature using a comprehensive search of original, peer-reviewed research articles involving human participants with sport-related concussion (SRC) published between January 1, 2010 and December 31, 2019. Data Selection Articles were identified in a comprehensive online search using key terms to encompass all forms of SRC or mTBI and entered into a clustering algorithm (vosViewer). Each cluster (e.g., journal, institution, author, keyword) is named for the hub, or most highly interconnected individual node. Data Synthesis The online search yielded 6,130 articles, 528 journals, 7,598 authors, 1,966 institutions, and 3,293 keywords. The analysis supported five thematic clusters of journals: 1. Biomechanics/Sports medicine (n = 15), 2. Pediatrics/Rehabilitation (n = 15), 3. Neurotrauma/Neurology/Neurosurgery (n = 11), 4. General Sports Medicine (n = 11), 5. Neuropsychology (n = 7). The analysis identified four institutional clusters: 1. University of North Carolina (n = 19), 2. University of Toronto (n = 19), 3. University of Michigan (n = 11), 4. University of Pittsburgh (n = 10). Five primary author clusters were identified: 1. A. Kontos (n = 32), 2. G. Iverson (n = 27), 3. M. McCrea (n = 27), 4. S. Broglio (n = 25), 5. Z. Kerr (n = 16). In regards to keywords, central topics included: 1. Epidemiology (n = 14), 2. Rehabilitation (n = 12), 3. Biomechanics (n = 11), 4. Imaging (n = 10), 5. Assessment (n = 9). Conclusions The findings suggest that during the past decade SRC research has: 1) been published primarily in sports medicine, pediatric, and neuro-focused journals, 2) involved a select group of researchers from several key institutions, and 3) focused on new topic areas including treatment/rehabilitation.

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Thorpe, Alister, Wendy Anders, and Kevin Rowley. "The community network: an Aboriginal community football club bringing people together." Australian Journal of Primary Health 20, no. 4 (2014): 356. http://dx.doi.org/10.1071/py14051.

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There are few empirical studies about the role of Aboriginal sporting organisations in promoting wellbeing. The aim of the present study was to understand the impact of an Aboriginal community sporting team and its environment on the social, emotional and physical wellbeing of young Aboriginal men, and to identify barriers and motivators for participation. A literature review of the impact of sport on the health and wellbeing of Aboriginal participants was conducted. This informed a qualitative study design with a grounded theory approach. Four semistructured interviews and three focus groups were completed with nine current players and five past players of the Fitzroy Stars Football Club to collect data about the social, emotional and physical wellbeing impact of an Aboriginal football team on its Aboriginal players. Results of the interviews were consistent with the literature, with common concepts emerging around community connection, cultural values and identity, health, values, racism and discrimination. However, the interviews provided further detail around the significance of cultural values and community connection for Aboriginal people. The complex nature of social connections and the strength of Aboriginal community networks in sports settings were also evident. Social reasons were just as important as individual health reasons for participation. Social and community connection is an important mechanism for maintaining and strengthening cultural values and identity. Barriers and motivators for participation in Aboriginal sports teams can be complex and interrelated. Aboriginal sports teams have the potential to have a profound impact on the health of Aboriginal people, especially its players, by fostering a safe and culturally strengthening environment and encompassing a significant positive social hub for the Aboriginal community.

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Monteagudo, S., F. M. Cornelis, X. Wang, A. DE Roover, J. Quintiens, T. Peeters, A. Sermon, R. C. DE Almeida, I. Meulenbelt, and R. J. Lories. "ANP32A is a hub molecule regulating a protective network against osteoarthritis." Osteoarthritis and Cartilage 28 (April 2020): S90. http://dx.doi.org/10.1016/j.joca.2020.02.137.

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Maslova, Irina, Rasulya Aetdinova, Aleksandr Koskin, and Kristina Dudina. "Prospects for creating a digital service E-Lean-Hub in a lean university model." E3S Web of Conferences 159 (2020): 09004. http://dx.doi.org/10.1051/e3sconf/202015909004.

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Modern universities are small cities. They have libraries, sports complexes, swimming pools, dormitories, catering, auditoriums, payment centres, and payment terminals. There are residents in them - students, teachers and employees, there are guests - applicants, parents, employers, and partners. In order to let all these work, the proper and effective management system is to be developed. Each resident and guest of the university should have an appropriate access to the resources and services according to their role. The development of digital technologies in a single university is not yet an indicator of quality of education since such technologies are just a tool. Universities are implementing a non-profit mission, but processes are becoming more and more business units, which involves the use of business management technologies in education to increase its effectiveness in the digital economy. In order to learn how to use it in a most effective way, experience of the foreign universities where such a model is already well applied and developed is crucial. In this regard, the article considers the mechanism of implementation of this system.

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Qin, Yong, Jia Li, Yonggang Zhou, Chengliang Yin, Yi Li, Ming Chen, Yinqiao Du, Tiejian Li, and Jinglong Yan. "Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis." CARTILAGE 13, no. 1_suppl (October 31, 2021): 1702S—1717S. http://dx.doi.org/10.1177/19476035211053824.

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Objective Synovial inflammation influences the progression of osteoarthritis (OA). Herein, we aimed to identify potential biomarkers and analyze transcriptional regulatory-immune mechanism of synovitis in OA using weighted gene coexpression network analysis (WGCNA). Design A data set of OA synovium samples (GSE55235) was analyzed based on WGCNA. The most significant module with OA was identified and function annotation of the module was performed, following which the hub genes of the module were identified using Pearson correlation and a protein-protein interaction network was constructed. A transcriptional regulatory network of hub genes was constructed using the TRRUST database. The immune cell infiltration of OA samples was evaluated using the single-sample Gene Set Enrichment Analysis (ssGSEA) method. The hub genes coexpressed in multiple tissues were then screened out using data sets of synovium, cartilage, chondrocyte, subchondral bone, and synovial fluid samples. Finally, transcriptional factors and coexpressed hub genes were validated via experiments. Results The turquoise module of GSE55235 was identified via WGCNA. Functional annotation analysis showed that “mineral absorption” and “FoxO signaling pathway” were mostly enriched in the module. JUN, EGR1, FOSB, and KLF4 acted as central nodes in protein-protein interaction network and transcription factors to connect several target genes. “Activated B cell,” “activated CD4T cell,” “eosinophil,” “neutrophil,” and “type 17 T helper cell” showed high immune infiltration, while FOSB, KLF6, and MYBL2 showed significant negative correlation with type 17 T helper cell. Conclusions Our results suggest that the expression level of apolipoprotein D (APOD) was correlated with OA. Furthermore, transcriptional regulatory-immune network was constructed, which may contribute to OA therapy.

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ADAMENKO, Viacheslav. "DEVELOPMENT OF CALCULATION AND DETAILING METHODS OF STEEL BUILDINGS: FROM THE EIFFEL TOWER TO THE NATIONAL STADIUM OF SINGAPORE SPORTS HUB." Building constructions. Theory and Practice, no. 11 (December 26, 2022): 32–43. http://dx.doi.org/10.32347/2522-4182.11.2022.32-43.

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From the analysis of the principles and methods of designing the world-famous Eiffel Tower, which at the time of its construction was the tallest tower in the world (312.12 m), and the National Stadium of Singapore sports hub, which is the largest steel dome in the world (diameter 310 m), the transformation of approaches to calculation and detailing of steel buildings was followed. Based on the architectural, structural, organizational, technological and economic parts of the original project of the Eiffel Tower, the process of its design and construction is considered in detail. It is shown that the design and construction of the tower was carried out with thorough theoretical preparation, extensive use of mathematical apparatus, manual calculations of all parts of the project, the use of railways, steam cranes and industrial production of parts of steel structures. The sequence of project development and construction of the dome of the National Stadium of Singapore sports hub was analyzed, with the creation of a 3D parametric model, calculations using the finite element method, computer optimization of the shape and size of structural parts, programming of special modules and development of algorithms to ensure the compatible operation of various software complexes, and design, detailing, development of drawings, as well as the transfer of all necessary information to the metal construction plant, for their production on CNC machines, using 3D BIM information systems. It was concluded that thanks to the development of information technologies, there was a transition from manual execution to the predominant use of computer methods of calculation and detailing of steel buildings. Ways to improve the further development of methods and approaches to the calculation and detailing of steel buildings are proposed.

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Eagle, Shawn R., Anthony P. Kontos, Micky W. Collins, Chris Connaboy, and Shawn D. Flanagan. "Network Analysis of Sport-Related Concussion Research During the Past Decade (2010–2019)." Journal of Athletic Training 56, no. 4 (February 4, 2021): 396–403. http://dx.doi.org/10.4085/1062-6050-0280.20.

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Context Research into sport-related concussion (SRC) has grown substantially over the past decade, yet no authors to date have synthesized developments over this critical time period. Objective To apply a network-analysis approach in evaluating trends in the SRC literature using a comprehensive search of original, peer-reviewed research articles involving human participants published between January 1, 2010, and December 15, 2019. Design Narrative review. Main Outcome Measure(s) Bibliometric maps were derived from a comprehensive search of all published, peer-reviewed SRC articles in the Web of Science database. A clustering algorithm was used to evaluate associations among journals, organizations or institutions, authors, and key words. The online search yielded 6130 articles, 528 journals, 7598 authors, 1966 organizations, and 3293 key words. Results The analysis supported 5 thematic clusters of journals: (1) biomechanics/sports medicine (n = 15), (2) pediatrics/rehabilitation (n = 15), (3) neurotrauma/neurology/neurosurgery (n = 11), (4) general sports medicine (n = 11), and (5) neuropsychology (n = 7). The analysis identified 4 organizational clusters of hub institutions: (1) University of North Carolina (n = 19), (2) University of Toronto (n = 19), (3) University of Michigan (n = 11), and (4) University of Pittsburgh (n = 10). Network analysis revealed 8 clusters for SRC key words, each with a central topic area: (1) epidemiology (n = 14), (2) rehabilitation (n = 12), (3) biomechanics (n = 11), (4) imaging (n = 10), (5) assessment (n = 9), (6) mental health/chronic traumatic encephalopathy (n = 9), (7) neurocognition (n = 8), and (8) symptoms/impairments (n = 5). Conclusions The findings suggest that during the past decade, SRC research has (1) been published primarily in sports medicine, pediatric, and neuro-focused journals, (2) involved a select group of researchers from several key institutions, and (3) concentrated on new topical areas, including treatment or rehabilitation and mental health.

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Wang, Haitang, J. Lee, and Ye Tian. "Critical Genes in White Adipose Tissue Based on Gene Expression Profile Following Exercise." International Journal of Sports Medicine 40, no. 01 (November 29, 2018): 57–61. http://dx.doi.org/10.1055/a-0768-7866.

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AbstractExercise is recognized as an effective method to prevent obesity and alleviate metabolic diseases. Browning of white adipose has the advantage of decreasing insulin resistance. We aim to identify critical differentially expressed genes (DEGs) in white adipose tissue after exercise. We downloaded the gene dataset GSE68161 of C57BL/6 mice from the Gene Expression Omnibus (GEO) database. Then, we analyzed the effect of exercise on up-regulated and down-regulated DEGs by GEO2R and performed protein-protein interaction network analyses. We then identified hub-genes in white adipose tissue and crosstalk genes of a single pathway by the STRING database and Cytoscape. In this study, 72 DEGs were screened out, and they mainly function in glycerol-3-phosphate dehydrogenase activity and in the primary biological process of fatty acid oxidation regulation. The top 5 hub-genes screened out were SLC27A1, COX7A1, PPARGC1A, FABP3, and UCP1. The 3 crosstalk genes found were SLC27A1, SLC27A2, and PPARA. These 3 genes might function as a bridge of the PPAR signaling pathway, adipocytokine signaling pathway and the insulin resistance pathway. SLC27A1 is critical gene for the interactions of signaling pathways in subcutaneous white adipose tissue. Therefore, further relationships between the browning of white adipose and insulin resistance need to be studied.

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Bellew, William, Ben J. Smith, Tracy Nau, Karen Lee, Lindsey Reece, and Adrian Bauman. "Whole of Systems Approaches to Physical Activity Policy and Practice in Australia: The ASAPa Project Overview and Initial Systems Map." Journal of Physical Activity and Health 17, no. 1 (January 1, 2020): 68–73. http://dx.doi.org/10.1123/jpah.2019-0121.

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Background: The literature on whole of system approaches (WSAs) has been largely theoretical in focus. The Australian Systems Approaches to Physical Activity is a national project designed to contribute a practical implementation focus to such approaches at the population level. Methods: National meetings were convened with federal and state government sector stakeholders to identify physical activity (PA) related policies and programs. Policies and programs were audited to develop an understanding of the existing PA system. A WSA conceptual map for PA was developed using feedback from system stakeholders, existing WSAs, and related work in obesity. Results: Completion of the policy audit has revealed key areas of need regarding policy governance, coordination, financing, and evaluation. An initial WSA conceptual map for Australia has been developed incorporating governance, translation, and advocacy. Stakeholder co-production of an integrated framework for PA and design plans for a community of practice knowledge hub has commenced. Conclusions: In Australia, Australian Systems Approaches to Physical Activity project partners have developed a conceptual whole of systems map that is guiding progress beyond the theoretical to application in the real world: a national PA policy audit, co-production of an integrated PA policy framework, and planning for a PA community of practice knowledge hub.

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Lariviere, Ophélie, Delphine Chadefaux, Christophe Sauret, Layla Kordulas, and Patricia Thoreux. "Modal Characterization of Manual Wheelchairs." Vibration 5, no. 3 (July 21, 2022): 442–63. http://dx.doi.org/10.3390/vibration5030025.

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Manual wheelchair (MWC) users are exposed to whole-body vibrations (WBVs) during propulsion. Vibrations enter the MWC structure through the wheels’ hub, propagate according to the MWC dynamical response, and finally reach the user’s body by the footrest, seat, backrest, and handrims. Such exposure is likely to be detrimental to the user’s health and a source of discomfort and fatigue which could, in daily life, impact users’ social participation and performance in sports. To reduce WBV exposure, a solution relies on MWC dynamical response modelling and simulation, where the model could indeed be used to identify parameters that improve the MWC dynamic. As a result, it is necessary to first assess the MWC dynamical response. In this approach, experimental modal analyses were conducted on eleven MWCs, including daily and sport MWCs (tennis, basketball, and racing). Through this procedure, modal properties (i.e., modal frequencies, damping parameters, and modal shapes) were identified for each MWC part. The results pointed out that each MWC investigated, even within the same group, revealed specific vibration properties, underlining the difficulty of developing a single vibration-reducing system for all MWCs. Nevertheless, several common dynamical properties related to MWC comfort and design were identified.

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Christensen, David D., Bruce D. Beynnon, Stephen D. Daniels, Cris J. Salinas, Michael Blankstein, and Nathaniel J. Nelms. "Comparison of Tip- Versus Hub-Oscillating Saw Blade Control in a Total Knee Arthroplasty Model." Journal of Arthroplasty 35, no. 11 (November 2020): 3300–3304. http://dx.doi.org/10.1016/j.arth.2020.06.019.

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D’Angelo, Fabio, Luca Monestier, Giovanni De Falco, Michael Mazzacane, and Placido Stissi. "Management of Traumatology Patients During the Coronavirus (COVID-19) Pandemic: Experience in a Hub Trauma Hospital in Northern Italy." Indian Journal of Orthopaedics 54, S2 (October 23, 2020): 397–402. http://dx.doi.org/10.1007/s43465-020-00282-5.

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Abstract Background As a result of the uncontrolled spread of the COVID-19 virus infection, a health reorganization according to the “hub and spoke” model was necessary. The purpose of the article was to document the adopted corporate protocol and describe the management of the traumatized patient in a Hub center. Methods Our hospital has been identified as one of the three regional Hubs for polytrauma and major traumas, requiring suitable pathways to receive confirmed or suspected COVID-19-positive patients, from the emergency room entrance to the operating room, and finally to the inpatient ward or ICU. From February 23th to April 30th 2020 we analyzed the total number of trauma patients hospitalized and the number of femoral neck fractures surgically treated within 48 h; the data were then compared with the corresponding period of the previous year. Results There has been a reduction in the overall number of traumas as a result of government restraint measures. Total occupancy time in the operating theater has increased, but not drastically considering dressing procedures and anesthesia (carried out inside the operating room). The number of patients with femoral neck fractures surgically treated within 48 h (none of the COVID-19-positive patients) decreased from 83.33 to 58.70%, but only slightly lower than the Italian pre-COVID average of 64.70%. Conclusions The correct management of the hospital and the meticulous organization of the traumatized patient have made it possible to contain the potential negative effects on the medical care quality during this unexpected and severe health emergency.

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Bohr, Adam D., Doug F. Aukerman, Kimberly G. Harmon, Russell Romano, Theresa D. Hernández, Niki Konstantinides, David J. Petron, et al. "Pac-12 CARE-Affiliated Program: structure, methods and initial results." BMJ Open Sport & Exercise Medicine 7, no. 2 (May 2021): e001055. http://dx.doi.org/10.1136/bmjsem-2021-001055.

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Sport-related concussion has garnered increasing scientific attention and research over the last decade. Collegiate student-athletes represent an important cohort in this field. As such, the Pac-12 CARE-Affiliated Program (CAP) was formed in 2017 as a regional hub of the Concussion Assessment, Research and Education (CARE) consortium. CAP is multisite, prospective, longitudinal study that aims to improve student-athlete health by identifying factors associated with concussion incidence and recovery and using this knowledge to inform best clinical practices and policy decisions. CAP employed a staggered rollout across the Pac-12, with the first four institutions enrolling in fall 2018. After receiving institutional review board (IRB) approval, these institutions began consenting student-athletes to share clinical concussion and baseline data for research purposes. Athletes completed baseline testing that included a medical questionnaire, concussion history and a battery for clinical concussion assessments. Concussed student-athletes were given the same battery of assessments in addition to full injury and return to play reports. Clinicians at each university worked with a data coordinator to ensure appropriate reporting, and the Pac-12 Concussion Coordinating Unit at the University of Colorado Boulder provided oversight for quality control of the data study wide. During year 1, CAP consented 2181 student-athletes and tracked 140 concussions. All research was conducted with the appropriate IRB approval across the participating Pac-12 institutions. Data security and dissemination are managed by the Presagia Sports Athlete Electronic Health Record software (Montreal, Quebec, Canada) and QuesGen Systems (San Francisco, California, USA).

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Westlake, Bryce, Martin Bouchard, and Richard Frank. "Assessing the Validity of Automated Webcrawlers as Data Collection Tools to Investigate Online Child Sexual Exploitation." Sexual Abuse 29, no. 7 (November 26, 2015): 685–708. http://dx.doi.org/10.1177/1079063215616818.

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The distribution of child sexual exploitation (CE) material has been aided by the growth of the Internet. The graphic nature and prevalence of the material has made researching and combating difficult. Although used to study online CE distribution, automated data collection tools (e.g., webcrawlers) have yet to be shown effective at targeting only relevant data. Using CE-related image and keyword criteria, we compare networks starting from CE websites to those from similar non-CE sexuality websites and dissimilar sports websites. Our results provide evidence that (a) webcrawlers have the potential to provide valid CE data, if the appropriate criterion is selected; (b) CE distribution is still heavily image-based suggesting images as an effective criterion; (c) CE-seeded networks are more hub-based and differ from non-CE-seeded networks on several website characteristics. Recommendations for improvements to reliable criteria selection are discussed.

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Doran, A. "Lessons learned from implementing a first contact physiotherapy service via a single and dual hub model. A narrative." Physiotherapy 113 (December 2021): e144. http://dx.doi.org/10.1016/j.physio.2021.10.138.

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Yang, Jianle, Yu Fan, and Shuzhong Liu. "ATF3 as a potential diagnostic marker of early-stage osteoarthritis and its correlation with immune infiltration through bioinformatics analysis." Bone & Joint Research 11, no. 9 (September 1, 2022): 679–89. http://dx.doi.org/10.1302/2046-3758.119.bjr-2022-0075.r1.

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Aims This study aimed, through bioinformatics analysis, to identify the potential diagnostic markers of osteoarthritis, and analyze the role of immune infiltration in synovial tissue. Methods The gene expression profiles were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified by R software. Functional enrichment analyses were performed and protein-protein interaction networks (PPI) were constructed. Then the hub genes were screened. Biomarkers with high value for the diagnosis of early osteoarthritis (OA) were validated by GEO datasets. Finally, the CIBERSORT algorithm was used to evaluate the immune infiltration between early-stage OA and end-stage OA, and the correlation between the diagnostic marker and infiltrating immune cells was analyzed. Results A total of 88 DEGs were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated that DEGs were significantly enriched in leucocyte migration and interleukin (IL)-17 signalling pathways. Disease ontology (DO) indicated that DEGs were mostly enriched in rheumatoid arthritis. Six hub genes including FosB proto-oncogene, AP-1 transcription factor subunit (FOSB); C-X-C motif chemokine ligand 2 (CXCL2); CXCL8; IL-6; Jun proto-oncogene, AP-1 transcription factor subunit (JUN); and Activating transcription factor 3 (ATF3) were identified and verified by GEO datasets. ATF3 (area under the curve = 0.975) turned out to be a potential biomarker for the diagnosis of early OA. Several infiltrating immune cells varied significantly between early-stage OA and end-stage OA, such as resting NK cells (p = 0.016), resting dendritic cells (p = 0.043), and plasma cells (p = 0.043). Additionally, ATF3 was significantly correlated with resting NK cells (p = 0.034), resting dendritic cells (p = 0.026), and regulatory T cells (Tregs, p = 0.018). Conclusion ATF3 may be a potential diagnostic marker for early diagnosis and treatment of OA, and immune cell infiltration provides new perspectives for understanding the mechanism during OA progression. Cite this article: Bone Joint Res 2022;11(9):679–689.

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Arjmand, Babak, Mostafa Rezaei-Tavirani, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Mahmood Khodadoost, Farshad Okhovatian, Mona Zamanian-Azodi, and Mojtaba Ansari. "Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis." Journal of Lasers in Medical Sciences 13 (September 23, 2022): e39. http://dx.doi.org/10.34172/jlms.2022.39.

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Introduction: Conventional fractionation (CF) and hypofractionation (HF) are two radiotherapy methods against cancer, which are applied in medicine. Understanding the efficacy and molecular mechanism of the two methods implies more investigations. In the present study, proteomic findings about the mentioned methods relative to the controls were analyzed via network analysis.Methods: The significant differentially expressed proteins (DEPs) of prostate cancer (PCa) cell line DU145 in response to CF and HF radiation therapy versus controls were extracted from the literature. The protein-protein interaction (PPI) networks were constructed via the STRING database via Cytoscape software. The networks were analyzed by "NetworkAnalyzer" to determine hub DEPs.Results: 126 and 63 significant DEPs were identified for treated DU145 with CF and HF radiation respectively. The PPI networks were constructed by the queried DEPs plus 100 first neighbors. ALB, CD44, THBS1, EPCAM, F2, KRT19, and MCAM were highlighted as common hubs. VTM, OCLN, HSPB1, FLNA, AHSG, and SERPINC1 appeared as the discriminator hub between the studied cells.Conclusion: 70% of the hubs were common between CF and HF conditions, and they induced radio-resistance activity in the survived cells. Six central proteins which discriminate the function of the two groups of the irradiated cells were introduced. On the basis of these findings, it seems that DU145-CF cells, relative to the DU145-UF cells, are more radio-resistant.

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Pruseth, Babita, Amit Ghosh, Dibyabhaba Pradhan, Suvendu Purkait, and Praveen Kumar Guttula. "Analysis of Overexpressed miRNA in Circulation and Cancer Tissue to Develop a Potential microRNA Panel for the Diagnosis of Colorectal Cancer." MicroRNA 10, no. 4 (December 2021): 250–62. http://dx.doi.org/10.2174/2211536611666211228102644.

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Background: Colorectal cancer (CRC) represents the world’s fourth deadly cancer, but its early diagnosis can be curative with considerable success rates. This study was aimed to identify CRC specific microRNAs (miRNAs) in tissue and serum samples to develop a miRNA-based diagnostics panel for the minimal invasive detection of CRC in early condition. Methods: By integrating four microarrays in tissue and serum samples of CRC from Gene Expression Omnibus (GEO) database, we screened out the highly expressed miRNAs in each dataset by using limma R package. Two important upregulated miRNAs namely hsa-miR-1246 and hsa-miR-1825 were overlapped in both tissue and serum samples of CRC, and were investigated to target identification, followed by functional annotation and protein- protein interaction (PPI) study for the target genes through DAVID and STRING respectively. Finally, hub target genes were retrieved by Cytoscape analysis. Results: It was shown that target genes of hsa-miR-1246 and hsa-miR-1825 were involved with core KEGG pathways (such as cAMP, PI3K-Akt and calcium signaling pathway). In addition, biological processes (such as cell adhesion and cell proliferation), cellular components (such as plasma membrane and cytosol), molecular functions (such as protein binding and metal ion binding), were mostly associated with the target genes. Their top 5 target genes were retrieved and their biological function towards tumor progression was shown using Cancer Hallmarks Analytics Tool. Conclusion: This study suggested that hsa-miR-1246 and hsa-miR-1825, as overlapped upregulated tissue and circulating miRNAs might have a vital role in the development of CRC and their five hub target genes were identified.

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Emken, B. Adar, Ming Li, Gautam Thatte, Sangwon Lee, Murali Annavaram, Urbashi Mitra, Shrikanth Narayanan, and Donna Spruijt-Metz. "Recognition of Physical Activities in Overweight Hispanic Youth Using KNOWME Networks." Journal of Physical Activity and Health 9, no. 3 (March 2012): 432–41. http://dx.doi.org/10.1123/jpah.9.3.432.

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Background:KNOWME Networks is a wireless body area network with 2 triaxial accelerometers, a heart rate monitor, and mobile phone that acts as the data collection hub. One function of KNOWME Networks is to detect physical activity (PA) in overweight Hispanic youth. The purpose of this study was to evaluate the in-laboratory recognition accuracy of KNOWME.Methods:Twenty overweight Hispanic participants (10 males; age 14.6 ± 1.8 years), underwent 4 data collection sessions consisting of 9 activities/session: lying down, sitting, sitting fidgeting, standing, standing fidgeting, standing playing an active video game, slow walking, brisk walking, and running. Data were used to train activity recognition models. The accuracy of personalized and generalized models is reported.Results:Overall accuracy for personalized models was 84%. The most accurately detected activity was running (96%). The models had difficulty distinguishing between the static and fidgeting categories of sitting and standing. When static and fidgeting activity categories were collapsed, the overall accuracy improved to 94%. Personalized models demonstrated higher accuracy than generalized models.Conclusions:KNOWME Networks can accurately detect a range of activities. KNOWME has the ability to collect and process data in real-time, building the foundation for tailored, real-time interventions to increase PA or decrease sedentary time.

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Heidari, Mohammad Hossein, Mona Zamanian Azodi, Mohammad Reza Zali, and Zahra Akbari. "Light at Night Exposure Effects on Differentiation and Cell Cycle in the Rat Liver With Autonomic Nervous System Denervation." Journal of Lasers in Medical Sciences 10, no. 5 (December 1, 2019): S43—S48. http://dx.doi.org/10.15171/jlms.2019.s8.

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Introduction: N Exposure to artificial light at night (LAN) affects human health and causes several functional modifications in the body. Obesity, diabetes, and hormonal changes are reported after exposure to LAN in humans. This study aims to highlight the critical features of biological terms that are affected in the liver of rats which received autonomic nervous system denervation. Methods: The liver gene expression profiles of 8 male Wistar rats that received sympathetic plus parasympathetic hepatic denervation and were exposed to LAN from Gene Expression Omnibus (GEO) for 1 hour were compared with 5 controls. The significant differentially-expressed genes (DEGs) were screened by the protein-protein interaction (PPI) network analysis STRING database (an application of Cytoscape software). Also, CuleGO and CleuDedia, the 2 applications of Cytoscape software, were used for more analysis. Results: Among 250 DEGs, 173 characterized genes with fold change more than 2 plus 100 added relevant genes were included in the PPI network. The analysis of the main connected component (MCC) led to introducing 15 hubs and 15 bottlenecks. CCT2, COPS7A, KAT2A, and ERCC1 were determined as hub-bottlenecks. Among hubs and bottlenecks, DHX15, KAT2A, CCT2, HSP90AB1, CCNE1, DHX16, LSM2, WEE1, CWC27, BAZ1B, RAB22A, DNM2, and DHX30 were linked to each other by various kinds of actions. CCT2 and KAT2A, the 2 hub-bottlenecks, were included in the interacted genes in the action map. Four classes of biological terms including negative regulation of non-motile cilium assembly, negative regulation of transforming growth factor beta activation, alpha-tubulin acetylation, and histamine-induced gastric acid secretion were identified as the critical biochemical pathways and biological processes. Conclusion: Several essential functions such as differentiation, cell cycle, ribosome assembly, and splicing are affected by LAN in rat livers with autonomic nervous system denervation.

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Zhou, Wei. "Preparation and Properties of HGBTPU Composite Foam for Football Protection." Advances in Materials Science and Engineering 2022 (August 17, 2022): 1–10. http://dx.doi.org/10.1155/2022/1632155.

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Football is a very dangerous sport. In order to reduce the injury of athletes, we must have corresponding protective articles, and the materials used are very important. Foam material has attracted the attention of all circles for its light weight, high strength, strong absorption impact load, and good heat insulation performance. However, the mechanical properties of foam materials will decrease with the decrease of density, which limits their application in sports, especially in some sports occasions, such as motorcycle competition, football, and other sports protection. In this paper, HGB/TPU foam materials are mainly studied. The material not only has good shock absorption performance but also has light weight and good mechanical properties. It can be used as protective equipment for football. In this paper, HGB/TPU composite foam materials were prepared by extrusion foaming method using TPU and HGB as raw materials. The effects of HGB surface modification, foaming agent content, and HGB content on the cellular structure and mechanical properties of composite foams were also investigated. The experimental results show that when the foaming method is extrusion foaming, the content of HGB is 3% and the content of foaming agent is 1.5%. It has better resistance to external forces, which helps to protect athletes from serious injuries.

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Duc, Sébastien, Vincent Villerius, William Bertucci, and Frédéric Grappe. "Validity and Reproducibility of the Ergomo®Pro Power Meter Compared With the SRM and Powertap Power Meters." International Journal of Sports Physiology and Performance 2, no. 3 (September 2007): 270–81. http://dx.doi.org/10.1123/ijspp.2.3.270.

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Purpose:The Ergomo®Pro (EP) is a power meter that measures power output (PO) during outdoor and indoor cycling via 2 optoelectronic sensors located in the bottom bracket axis. The aim of this study was to determine the validity and the reproducibility of the EP compared with the SRM crank set and Powertap hub (PT).Method:The validity of the EP was tested in the laboratory during 8 submaximal incremental tests (PO: 100 to 400 W), eight 30-min submaximal constant-power tests (PO = 180 W), and 8 sprint tests (PO > 750 W) and in the field during 8 training sessions (time: 181 ± 73 min; PO: ~140 to 150 W). The reproducibility was assessed by calculating the coefficient of PO variation (CV) during the submaximal incremental and constant tests.Results:The EP provided a significantly higher PO than the SRM and PT during the submaximal incremental test: The mean PO differences were +6.3% ± 2.5% and +11.1% ± 2.1%, respectively. The difference was greater during field training sessions (+12.0% ± 5.7% and +16.5% ± 5.9%) but lower during sprint tests (+1.6% ± 2.5% and +3.2% ± 2.7%). The reproducibility of the EP is lower than those of the SRM and PT (CV = 4.1% ± 1.8%, 1.9% ± 0.4%, and 2.1% ± 0.8%, respectively).Conclusions:The EP power meter appears less valid and reliable than the SRM and PT systems.

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Scott, Janelle, and Huriya Jabbar. "The Hub and the Spokes." Educational Policy 28, no. 2 (January 30, 2014): 233–57. http://dx.doi.org/10.1177/0895904813515327.

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Bonilla, Diego A., Yurany Moreno, Eric S. Rawson, Diego A. Forero, Jeffrey R. Stout, Chad M. Kerksick, Michael D. Roberts, and Richard B. Kreider. "A Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation." Nutrients 13, no. 8 (July 23, 2021): 2521. http://dx.doi.org/10.3390/nu13082521.

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Creatine (Cr) and phosphocreatine (PCr) are physiologically essential molecules for life, given they serve as rapid and localized support of energy- and mechanical-dependent processes. This evolutionary advantage is based on the action of creatine kinase (CK) isozymes that connect places of ATP synthesis with sites of ATP consumption (the CK/PCr system). Supplementation with creatine monohydrate (CrM) can enhance this system, resulting in well-known ergogenic effects and potential health or therapeutic benefits. In spite of our vast knowledge about these molecules, no integrative analysis of molecular mechanisms under a systems biology approach has been performed to date; thus, we aimed to perform for the first time a convergent functional genomics analysis to identify biological regulators mediating the effects of Cr supplementation in health and disease. A total of 35 differentially expressed genes were analyzed. We identified top-ranked pathways and biological processes mediating the effects of Cr supplementation. The impact of CrM on miRNAs merits more research. We also cautiously suggest two dose–response functional pathways (kinase- and ubiquitin-driven) for the regulation of the Cr uptake. Our functional enrichment analysis, the knowledge-based pathway reconstruction, and the identification of hub nodes provide meaningful information for future studies. This work contributes to a better understanding of the well-reported benefits of Cr in sports and its potential in health and disease conditions, although further clinical research is needed to validate the proposed mechanisms.

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Heidari, Mohammad Hossein, Mohammadreza Razzaghi, Alireza Akbarzadeh Baghban, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mona Zamanian Azodi, Alireza Zali, and Alireza Ahmadzadeh. "Assessment of the Microbiome Role in Skin Protection Against UV Irradiation Via Network Analysis." Journal of Lasers in Medical Sciences 11, no. 3 (June 21, 2020): 238–42. http://dx.doi.org/10.34172/jlms.2020.40.

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Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, proteinprotein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.

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Rezaei Tavirani, Mostafa, Farshad Okhovatian, Mohammad Rostami Nejad, Babak Arjmand, and Zahra Razzaghi. "Predicting Radioresistant Biomarkers in Nasopharyngeal Carcinoma Patients Via Protein-Protein Interaction Network Analysis." Journal of Lasers in Medical Sciences 12, no. 1 (December 1, 2021): e76-e76. http://dx.doi.org/10.34172/jlms.2021.76.

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Introduction: Radiotherapy as the first-line nasopharyngeal carcinoma (NPC) treatment provides different responses including radioresistant and radiosensitive states. In order to investigate the molecular basis of radioresistancy, protein-protein interaction network analysis of proteome data prior to therapy was performed. Methods: 20 dysregulated proteins of the patients who were radioresistant were extracted from the literature. Cytoscape and its plug-ins were used for the resistant network construction and its centrality analysis. Furthermore, ClueGO+ CluePedia application determined the most statistically significant biological processes (BP) related to the hubs. Results: Fourteen hubs were concluded and no differentially expressed protein (DEP) was among these agents. Among the hubs, albumin (ALB) and fibronectin (FN1) were the hub-bottlenecks, and the Serpin family was present. What is more, SERPIND1 was the highest degree-valued DEP in the network. Conclusion: It can be concluded that the central elements of the NPC network could be noteworthy for improving the radiotherapy outcome and overcoming its limitations. However, complementary studies are required for a better understanding of their major role.

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Mansouri, Vahid, Mostafa Rezaei-Tavirani, Mohammad-Mehdi Zadeh-Esmaeel, Sina Rezaei-Tavirani, Mohammadreza Razzaghi, Farshad Okhovatian, Mohammad Rostami-Nejad, and Alireza Ahmadzade. "Analysis of Laser Therapy Effects on Squamous Cell Carcinoma Patients: A System Biology Study." Journal of Lasers in Medical Sciences 10, no. 5 (December 1, 2019): S1—S6. http://dx.doi.org/10.15171/jlms.2019.s1.

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Introduction: The Mechanism of laser therapy and also its safety are 2 important features of the application of different types of lasers in medicine. This study aims to investigate the critically affected genes after the treatment of squamous cell carcinoma patients. Methods: The gene expression profiles of 4 squamous cell carcinoma patients that were treated via chemoradiotherapy (CRT) plus the laser and 3 similar patients without laser exposure from Gene Expression Omnibus (GEO) were downloaded and were screened to find critical genes via network analysis. The STRING database, Cytoscape software, and the Clue GO plug-in of Cytoscape software were used. Results: The genes HSX70 and NCC27 were determined as neighbors and HSPA1B, CLIC1, RAB13, PPIF, and LCE3D as hub genes. The over-expression of LCE3D was interpreted as the side effect of laser therapy. Apoptosis and the cell cycle were the dominant biological processes regulated by the HSP molecules in the laser-treated patients. Conclusion: The laser affected the main biological processes and simultaneously issued side effects

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Mansouri, Vahid, Babak Arjmand, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Mahmood Khodadoost, Mostafa Rezaei Tavirani, Majid Rezaei Tavirani, and Alireza Ahmadzadeh. "Introducing BDNF and SNAI1 as the Crucial Targeted Genes by UV Radiation." Journal of Lasers in Medical Sciences 13 (December 27, 2022): e76. http://dx.doi.org/10.34172/jlms.2022.76.

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Introduction: Due to widespread penetration of UV radiation in human life, the biological effect of UV radiation is studied through many investigations in the field of medicine. There are many assessments about UV radiation which are concerned with protein-protein interaction (PPI) network analysis. In the present study, a network analysis associated with the complementary evaluation of UV radiation on human primary melanocytes is presented. Methods: The gene expression profiles of the irradiated human primary melanocytes and the control cells were extracted from Gene Expression Omnibus (GEO) and were evaluated via PPI network analysis and action map assessment. Results: 69 significant differentially expressed genes (DEGs) were included in the main component of the PPI network. Brain-derived neurotrophic factor (BDNF), SNAI1, and SOCS1 were highlighted as the top dysregulated and hub genes. Results indicate that BDNF and SNAI1 participate in the regulatory unit including the total hubs and top dysregulated genes. Conclusion: Considerable down-regulation of BDNF and up-regulation of SNAI1 as the two critical targeted genes by UV radiation are accompanied by gross alteration in cell functions.

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Rogers, Timothy T., and Matthew A. Lambon Ralph. "Semantic tiles or hub-and-spokes?" Trends in Cognitive Sciences 26, no. 3 (March 2022): 189–90. http://dx.doi.org/10.1016/j.tics.2022.01.002.

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Mansouri, Vahid, Mohammadreza Razzaghi, Mohammad Rostami-Nejad, Majid Rezaei-Tavirani, Mohammad Hossein Heidari, Saeed Safari, Babak Arjmand, Mostafa Rezaei-Tavirani, Alireza Zali, and Mostafa Hamdieh. "Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels." Journal of Lasers in Medical Sciences 11, no. 3 (June 21, 2020): 280–86. http://dx.doi.org/10.34172/jlms.2020.47.

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Introduction: Photobiomodulation (PBM) is known as low-level laser (or light) therapy and is applied in different fields of medicine. However, it is required that its molecular and cellular mechanism be investigated. This study aims to assess the neuroprotective properties of PBM in the rat retina. Methods: GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment. Results: The 78 produced DEGs by light-damage in the rat retina were protected via PBM pretreatment action. Among these determined DEGs, 53 individuals were included in the main connected component of the constructed protein-protein interaction (PPI) network. Ccl2, Icam1, Cxcl10, Timp1, and Fos were determined as hub nodes. Eight clusters including 26 regulated biochemical pathways by PBM pretreatment were identified. The critical DEGs based on the action maps were introduced. Conclusion: The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.

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Zadeh-Esmaeel, Mohammad-Mehdi, Shabnam Shahrokh, Mona Zamanian Azodi, and Nayebali Ahmadi. "The Highlighted Role of GAPDH and Nitric-Oxide Synthase Regulator Activity in Proton Beam Irradiated Melanoma BLM Cells." Journal of Lasers in Medical Sciences 10, no. 5 (December 1, 2019): S68—S72. http://dx.doi.org/10.15171/jlms.2019.s13.

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Introduction: The human melanoma is a type of invasive tumor the treatment of which is challenging. To better understand the proton irradiation mechanisms as one of the widely applied therapy for this type of cancer, bioinformatics analysis of proteomics outcome could be beneficial. Methods: Protein-protein interaction network analysis of the differentially expressed proteins (DEPs) of melanoma BLM (BRO lung metastasis) cells in the treatment of 3 Gy dosage proton therapy was performed in this study via Cytoscape V.3.7.2. and its integrated plug-ins. Results: Eighteen DEPs were searched for network constructions and limited numbers of query +neighbor proteins were found central. The hub-bottlenecks (i.e. central nodes) were GAPDH, ACTB, ALB, AKT1, TP53, and EGFR. The fist mentioned proteins were from DEPs. The enrichment analysis of these elements identified nitric-oxide synthase regulator activity and the positive regulation of the norepinephrine uptake that may be the key to the mechanisms of proton therapy. Conclusion: In conclusion, the identified central nodes (EGFR, TP53, ALB, AKT1, GAPDH, and ACTB) and the related biological terms are the critical affected genes and biological terms in the irradiated melanoma cells.

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Yuan, Wei, Maowei Yang, and Yue Zhu. "Development and validation of a gene signature predicting the risk of postmenopausal osteoporosis." Bone & Joint Research 11, no. 8 (August 1, 2022): 548–60. http://dx.doi.org/10.1302/2046-3758.118.bjr-2021-0565.r1.

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Aims We aimed to develop a gene signature that predicts the occurrence of postmenopausal osteoporosis (PMOP) by studying its genetic mechanism. Methods Five datasets were obtained from the Gene Expression Omnibus database. Unsupervised consensus cluster analysis was used to determine new PMOP subtypes. To determine the central genes and the core modules related to PMOP, the weighted gene co-expression network analysis (WCGNA) was applied. Gene Ontology enrichment analysis was used to explore the biological processes underlying key genes. Logistic regression univariate analysis was used to screen for statistically significant variables. Two algorithms were used to select important PMOP-related genes. A logistic regression model was used to construct the PMOP-related gene profile. The receiver operating characteristic area under the curve, Harrell’s concordance index, a calibration chart, and decision curve analysis were used to characterize PMOP-related genes. Then, quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of the PMOP-related genes in the gene signature. Results We identified three PMOP-related subtypes and four core modules. The muscle system process, muscle contraction, and actin filament-based movement were more active in the hub genes. We obtained five feature genes related to PMOP. Our analysis verified that the gene signature had good predictive power and applicability. The outcomes of the GSE56815 cohort were found to be consistent with the results of the earlier studies. qRT-PCR results showed that RAB2A and FYCO1 were amplified in clinical samples. Conclusion The PMOP-related gene signature we developed and verified can accurately predict the risk of PMOP in patients. These results can elucidate the molecular mechanism of RAB2A and FYCO1 underlying PMOP, and yield new and improved treatment strategies, ultimately helping PMOP monitoring. Cite this article: Bone Joint Res 2022;11(8):548–560.

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Ansari, Mojtaba, Mostafa Rezaei-Tavirani, Maryam Hamzeloo-Moghadam, Mohhamadreza Razzaghi, Babak Arjmand, Mona Zamanian Azodi, Mahmood Khodadoost, and Farshad Okhovatian. "Investigation into Chronic Low-Dose Ionizing Radiation Effect on Gene Expression Profile of Human HUVECs Cells." Journal of Lasers in Medical Sciences 13 (August 27, 2022): e35. http://dx.doi.org/10.34172/jlms.2022.35.

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Introduction: Understanding the molecular mechanism of chronic low-dose ionizing radiation (LDIR) effects on the human body is the subject of many research studies. Several aspects of cell function such as cell proliferation, apoptosis, inflammation, and tumorigenesis are affected by LDIR. Detection of the main biological process that is targeted by LIDR via network analysis is the main aim of this study. Methods: GSE66720 consisting of gene expression profiles of human umbilical vein endothelial cells (HUVECs) (a suitable cell line to be investigated), including irradiated and control cells, was downloaded from Gene Expression Omnibus (GEO). The significant differentially expressed genes (DEGs) were determined and analyzed via protein-protein interaction (PPI) network analysis to find the central individuals. The main cell function which was related to the central nodes was introduced. Results: Among 64 queried DEGs, 48 genes were recognized by the STRING database. C-X-C motif chemokine ligand 8 (CXCL8), intercellular adhesion molecule 1 (ICAM1), Melanoma growth-stimulatory activity/growth-regulated protein α (CXCL1), vascular cell adhesion molecule 1 (VCAM-1), and nerve growth factor (NGF) were introduced as hub nodes.Conclusion: Findings indicate that inflammation is the main initial target of LDIR at the cellular level which is associated with alteration in the other essential functions of the irradiated cells.

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Mohammadi, Sardar, and Omid Isanejad. "The Presentation of the Extended Technology Acceptance Model in Sports Organizations." Halabja University Journal 1, no. 2 (April 1, 2016): 967–80. http://dx.doi.org/10.32410/huj.10079.

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Marshall, Samantha, Nicola McNeil, Emma Louise Seal, and Matthew Nicholson. "Elite sport hubs during COVID-19: The job demands and resources that exist for athletes." PLOS ONE 17, no. 7 (July 5, 2022): e0269817. http://dx.doi.org/10.1371/journal.pone.0269817.

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In response to the COVID-19 pandemic, elite sport leagues implemented hubs, or ‘bubbles’, which restricted athletes’ movements and social interactions in order to minimise the risk of athlete infection and allow competitions to continue. This was a new way of working and living for elite athletes and there was a dearth of literature on this topic. The main objective of the study was to investigate the impacts of the hub model on athletes over time, and what job demands and resources existed for athletes through the application of Demerouti et al. (2001) Job Demands-Resources Model. Multiple sequential semi-structured interviews were conducted with Women’s National Basketball League (WNBL) athletes during the 2020 season, which was held entirely in a hub in North Queensland, Australia. The key job demands in an elite sport hub identified were the volume of work, simultaneous overload and underload, and nature of work in the hub. The key resources that emerged include recovery services, control and player agency, and constructive social relations. Despite the presence of job resources, which work to counteract, or buffer job demands in order to reduce work stress and improve motivation, they were found to be insufficient for athletes and inequitably distributed between clubs. The intensity of the hub model also amplified demands present in all WNBL seasons. This research is therefore useful for planning of future elite sport leagues to improve the type and amount of resources available to athletes, thereby improving athlete wellbeing and performance both within and outside a hub model.

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Miles, Lee. "Editorial: Moving Towards a ‘Hub and Spokes Europe’?" JCMS: Journal of Common Market Studies 41, S1 (August 14, 2003): 1–11. http://dx.doi.org/10.1111/1468-5965.41.s1.1.

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Taylor, Matthew. "The global ring? Boxing, mobility, and transnational networks in the anglophone world, 1890–1914." Journal of Global History 8, no. 2 (June 6, 2013): 231–55. http://dx.doi.org/10.1017/s174002281300020x.

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AbstractThis article examines professional boxing as a compelling and dynamic example of globalization from below between 1890 and 1914. It explores the sport's fluctuating legal and organizational status and maps the movement of professional boxers – and the networks that facilitated this movement – across the anglophone world. Boxing was particularly suited to cross-national mobility because it developed alongside, and built upon, the global circuits of the late nineteenth-century entertainment industry. Yet the main sites of the anglophone boxing world were not connected in any structured or standardized fashion. Channels of communication and routes of traffic were continually shifting, with no one city, region or nation emerging as a consistent hub of activity. This article explores boxing's fluid, multiple and loosely structured ‘networks’, and shows how the sport remained largely resistant to international regulation and standardization in this period.

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Misalucha‐Willoughby, Charmaine. "Contesting the Hub‐and‐Spokes Model in Southeast Asia." Asian Politics & Policy 12, no. 1 (January 2020): 57–70. http://dx.doi.org/10.1111/aspp.12511.

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Kurokawa, Hisayuki, Hiroyuki Yamato, and Takeo Koyama. "An Examination about the Hub-Spokes Type Transport Form." Journal of the Society of Naval Architects of Japan 1998, no. 184 (1998): 617–25. http://dx.doi.org/10.2534/jjasnaoe1968.1998.184_617.

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