Статті в журналах: "Spectroscopie RMN in vivo"

1

Bloch, G. "Etude par spectroscopie RMN in vivo du transport du glucose dans le muscle humain." médecine/sciences 14, no. 10 (1998): 1083. http://dx.doi.org/10.4267/10608/914.

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Roby, C., R. Bligny, and R. Douce. "Exploration de la cellule végétale par spectroscopie RMN." Journal de Chimie Physique 89 (1992): 253–70. http://dx.doi.org/10.1051/jcp/1992890253.

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3

Imperiale, A. "La spectroscopie RMN dans le diagnostic du phéochromocytome." Annales d'Endocrinologie 78, no. 4 (September 2017): 203. http://dx.doi.org/10.1016/j.ando.2017.07.748.

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Duchemann, B., M. Triba, D. Guez, H. Nunes, D. Valeyre, J. F. Bernaudin, and L. Le Moyec. "Étude par spectroscopie RMN du métabolisme salivaire dans la sarcoïdose." Revue des Maladies Respiratoires 29 (January 2012): A96—A97. http://dx.doi.org/10.1016/j.rmr.2011.10.313.

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Payen, J.-F., G. Francony, B. Fauvage, and J.-F. Le Bas. "Apport de la spectroscopie RMN à l'évaluation du traumatisme crânien." Annales Françaises d'Anesthésie et de Réanimation 24, no. 5 (May 2005): 522–27. http://dx.doi.org/10.1016/j.annfar.2005.03.005.

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Le Botlan, D. J. "Etude par spectroscopie rmn 13C de la solution aqueuse formaldehyde-methanol." Journal de Chimie Physique 84 (1987): 115–23. http://dx.doi.org/10.1051/jcp/1987840115.

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7

Lagarde, D., M. Pérès, B. Barrère, CY Guézennec, and C. Piérard. "Modafinil et aminoacides neurotransmetteurs cérébraux: étude par spectroscopie RMN et microdialyse." Neurophysiologie Clinique/Clinical Neurophysiology 26, no. 6 (January 1996): 435. http://dx.doi.org/10.1016/s0987-7053(97)89184-8.

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Gariod, L., A. Favre-Juvin, V. Novel, H. Reutenauer, H. Majean, and A. Rossi. "Évaluation du profil énergétique des judokas par spectroscopie RMN du P31." Science & Sports 10, no. 4 (January 1995): 201–7. http://dx.doi.org/10.1016/0765-1597(96)89370-1.

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9

Kozak-Reiss, G. "Nouvelles explorations de la fonction musculaire : spectroscopie RMN. Application à l'hyperthermie maligne." Annales Françaises d'Anesthésie et de Réanimation 8, no. 5 (January 1989): 400–405. http://dx.doi.org/10.1016/s0750-7658(89)80005-x.

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10

Touré, Assane, Cheikh Abdoul Khadir Diop, Libasse Diop, and Bernard Mahieu. "Synthèse et étude par spectroscopie Mössbauer, infrarouge et RMN de nouveaux complexes carboxylato organostanniques." Comptes Rendus Chimie 10, no. 6 (June 2007): 493–97. http://dx.doi.org/10.1016/j.crci.2006.06.014.

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11

Berte, N., L. Cayzergues, F. Meyer, H. Jira, M. Eugene, M. Conti, S. Loric, et al. "Évaluation par spectroscopie RMN des lésions rénales provoquées par la lithotripsie extracorporelle à partir d’échantillons d’urine." Progrès en Urologie 21, no. 7 (July 2011): 455–58. http://dx.doi.org/10.1016/j.purol.2011.02.009.

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Masse, M. O., C. Delporte, and E. Bervelt. "Identification de filtres solaires dérivés de l'acide para-aminobenzoique par spectroscopie RMN et par CPG/SM." International Journal of Cosmetic Science 23, no. 5 (October 2001): 259–79. http://dx.doi.org/10.1046/j.1467-2494.2001.00076.x.

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Kozak-Reiss, G., J. P. Gascard, and K. Redouane-Bénichou. "Dépistage de l'hyperthermie maligne anesthésique par les tests de contracture musculaire et par la spectroscopie RMN." Annales Françaises d'Anesthésie et de Réanimation 5, no. 6 (January 1986): 584–89. http://dx.doi.org/10.1016/s0750-7658(86)80067-3.

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Kaminsky, P., B. Robin-Lherbier, J. M. Escanye, P. Walker, F. Brunotte, J. Robert, and M. Duc. "Mécanismes de l'atteinte du métabolisme énergétique musculaire dans les dysthyroïdies. Étude par spectroscopie RMN du phosphore." La Revue de Médecine Interne 11, no. 3 (May 1990): S62. http://dx.doi.org/10.1016/s0248-8663(05)81967-8.

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Lavanchy, N., and A. Rossi. "Le lactate musculaire détecté par spectroscopie de RMN du carbone-13 et du proton: quelques éléments de réflexion." Science & Sports 8, no. 3 (January 1993): 221–24. http://dx.doi.org/10.1016/s0765-1597(05)80014-0.

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Sarazin, C., G. Goethals, JP Seguin, MD Legoy, and JN Barbotin. "Étude par spectroscopie RMN 1H et 13C de la synthèse d’esters en milieu organique catalysée par une lipase : influence de l’eau." Journal de Chimie Physique 89 (1992): 541–47. http://dx.doi.org/10.1051/jcp/1992890541.

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Drouet, Alain, Fabien Zagnoli, Monique Piraud, Nathalie Streichenberger, François Petit, Michel Bahuau, and Denis Vital Durand. "Intolérance musculaire à l’effort par déficit en phosphofructokinase : apport au diagnostic du bilan métabolique musculaire (tests d’effort, spectroscopie RMN au p31)." Revue Neurologique 168 (April 2012): A32. http://dx.doi.org/10.1016/j.neurol.2012.01.076.

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Drouet, A., F. Zagnoli, T. Fassier, F. Rannou, F. Baverel, M. Piraud, M. Bahuau, et al. "Intolérance musculaire à l’effort par déficit en phosphofructokinase : apport au diagnostic du bilan métabolique musculaire (tests d’effort, spectroscopie RMN du P31)." Revue Neurologique 169, no. 8-9 (August 2013): 613–24. http://dx.doi.org/10.1016/j.neurol.2013.02.006.

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19

Nicolay, K., R. M. Dijkhuizen, A. van der Toorn, T. Reese, D. Brandsma, M. de Boer, H. J. Muller, et al. "Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury." Acta Neuropsychiatrica 8, no. 4 (December 1996): 76–86. http://dx.doi.org/10.1017/s0924270800036966.

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SummaryThis article describes the use of non-invasive magnetic resonance (MR) methods for the characterization and monitoring of the pathophysiology of experimental brain injury in laboratory animals as a function of time and treatment. The impact of MR in brain research is primarily due to its non-invasive nature, thereby enabling repeated measurements in long-term studies, and due to the type of information that it provides. MR imaging (MRI) enables the measurement of the morphology/anatomy as well as the functional status of tissues under in vivo conditions. Compared to other in vivo imaging modalities, MRI has a high spatial resolution and allows for a remarkable soft tissue differentiation. MR spectroscopy (MRS) provides information on the biochemical/metabolic status of tissues. MR methods which have proven valuable in animal studies, can be readily translated to the clinical situation where MR-based diagnosis and treatment planning play a rapidly increasing role.After a short introduction into the principles of MR, we will illustrate the remarkable versatility of MR in research on brain injury from recent animal studies. Examples will be mainly drawn from experiments on early injury in focal cerebral ischemia and from research on mechanical brain trauma and excitotoxic lesions. The article ends with a brief description of the perspectives of MR in neuropsychiatry.

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Brambilla, Paolo, Francesco Barale, Edgardo Caverzasi, and Jair Constante Soares. "Anatomical MRI findings in mood and anxiety disorders." Epidemiologia e Psichiatria Sociale 11, no. 2 (June 2002): 88–99. http://dx.doi.org/10.1017/s1121189x00005558.

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RIASSUNTOScopo – Gli studi con Risonanza Magnetica Nucleare (RMN) hanno permesso la valutazione in vivo dell'anatomia cerebrale di vari disturbi psichiatrici e l'approfondimento degli ipotetici circuiti cerebrali disfunzionali coinvolti nella patofisiologia di queste malattie. In questo articolo abbiamo revisionato la letteratura comprendente gli studi con RMN condotti nei disturbi dell'umore e d'ansia. Metodi – Tutti gli studi in Inglese con RMN condotti in pazienti con disturbo dell'umore o d'ansia pubblicati tra il 1966 ed il gennaio 2002 sono stati identificati attraverso una ricerca Medline, completata dall'analisi manuale delle referenze bibliografiche. Risultati – Differenti aree anatomiche cerebrali sembrano essere coinvolte nei diversi sottotipi di disturbo dell'umore. Infatti, l'ippocampo ed i gangli della base sembrano essere anormali nei disturbo unipolare, mentre l'amigdala ed il cervelletto in quello bipolare. Questo suggerisce che le due malattie abbiano un substrata biologico distinto. Per quanto riguarda i disturbi d'ansia, le regioni orbito-frontali ed i gangli della base sembrano avere un'anatomia anormale nei disturbo ossessivo-compulsivo, i lobi temporali nei disturbo da attacchi di panico e l'ippocampo nei disturbo post-traumatico da stress. Conclusioni – I dati della letteratura riassunti in questo articolo suggeriscono che specifiche aree cerebrali siano coinvolte nella patofisiologia dei disturbi dell'umore e d'ansia. Tuttavia, gli studi a tutt'oggi a disposizione sono stati condotti su campioni relativamente piccoli di soggetti, spesso sottoposti a medicamenti psicotropi, e sono in gran parte studi trasversali. Per tale motivo gli studi con RMN in futuro dovranno avere un disegno di tipo longitudinale ed arruolare campioni più ampi di soggetti, possibilmente senza trattamento psicofarmacologico, al primo episodio di malattia o ad alto rischio di sviluppare un disturbo dell'umore o d'ansia. Inoltre, l'associazione di questo tipo di ricerche con studi di tipo genetico potranno essere estremamente utili per separare anomalie anatomiche cerebrali di stato da quelle di tratto e per ulteriormente caratterizzare la patofisiologia di questi disturbi.

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Petit, J. M., B. Bouillet, B. Guiu, P. Buffier, S. Baillot-Rudoni, M. C. Brindisi, E. Crevisy, et al. "P200 Effet d’un traitement par liraglutide sur le contenu hépatique en graisse de patients diabétiques de type 2: étude prospective par spectroscopie-RMN." Diabetes & Metabolism 41 (March 2015): A83. http://dx.doi.org/10.1016/s1262-3636(15)30313-x.

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Pedro, L., B. Guiu, G. Nuemi, M. Habchi, S. Verret, S. Favelier, J. P. Cercueil, B. Verges, and J. M. Petit. "P1048 Faible prévalence de la stéatose dans le diabète de type 1 : étude par spectroscopie-RMN chez 108 patients diabétiques de type 1." Diabetes & Metabolism 39 (March 2013): A43. http://dx.doi.org/10.1016/s1262-3636(13)71794-4.

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Claeys-Bruno, Magalie, Michel Bardet та Jean-Claude Marchon. "Détermination de la composition énantiomérique dˈesters dˈacides aminés par spectroscopie de RMN à lˈaide dˈune chiroporphyrine de cobalt(III) comme agent chiral de déplacement chimique". Comptes Rendus Chimie 5, № 1 (січень 2002): 21–25. http://dx.doi.org/10.1016/s1631-0748(02)01326-7.

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Le Curieux, F., F. Erb, and D. Marzin. "Identification de composés génotoxiques dans les eaux de boisson." Revue des sciences de l'eau 11 (April 12, 2005): 103–18. http://dx.doi.org/10.7202/705333ar.

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Depuis la mise en évidence de trihalométhanes dans les eaux potables en 1974, de multiples travaux ont démontré la présence de nombreux composés génotoxiques dans l'eau de boisson. L'eau potable obtenue à partir d'eau de surface subit un traitement incluant généralement une étape de chloration. Il est aujourd'hui largement admis que l'activité génotoxique des eaux de boisson provient principalement de la chloration des substances humiques, composés organiques naturels contenus dans l'eau brute et issus de la dégradation des déchets animaux et végétaux. Les très faibles concentrations en composés génotoxiques dans les eaux potables nécessitent la concentration des échantillons, procédé qui risque toutefois de modifier la génotoxicité. Plusieurs tests mettant en oeuvre des cellules procaryotes ou eucaryotes, des plantes ou des mammifères, ont permis de mettre en évidence les effets génotoxiques dans des eaux potables chlorées. L'identification des composés génotoxiques est réalisée au moyen des données de la spectrométrie de masse et de la spectroscopie UV ou RMN (proton ou carbone). Ces agents sont généralement non volatils, acides et polaires. Bien que certains composés inorganiques interviennent parfois, la majeure partie de la génotoxicité est attribuée aux agents organohalogénés (bromés ou/et chlorés), les principaux étant les trihalométhanes, acides acétiques, acétonitriles, cétones, et hydroxyfuranones. La fixation de normes contribue à limiter l'exposition des populations aux agents potentiellement dangereux. La qualité des eaux de boisson peut être accrue en utilisant une eau brute moins chargée en matière organique, et en améliorant le traitement chimique tout en veillant à conserver la qualité microbiologique de l'eau produite.

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Chabrol, B., J. Vion-Dury, S. Confort-Gouny, S. Lamoureux, AM Salvan, and PJ Cozzone. "Anomalies neurochimiques détectées in vivo par spectroscopie localisée de résonance magnétique dans les maladies lysosomales." Archives de Pédiatrie 2, no. 4 (April 1995): 389–90. http://dx.doi.org/10.1016/0929-693x(95)90178-6.

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Petit, J. M., C. Fourmont, B. Guiu, P. Buffier, B. Bouillet, M. C. Brindisi, E. Crevisy, S. Baillot-Rudoni, J. P. Cercueil, and B. Verges. "P210 Le contenu hépatique en graisse mesuré en spectroscopie-RMN n’est pas associé au déclin du débit de filtration glomérulaire chez les patients diabétiques de type 2." Diabetes & Metabolism 41 (March 2015): A86. http://dx.doi.org/10.1016/s1262-3636(15)30323-2.

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Chamkhi, A., O. Seloi, A. Heintz, G. Toubeau, M. Lefranc, J. Peltier, C. Desenclos, et al. "Glioblastomes : spectroscopie in vivo et anatomopathologie in vitro pour le pronostic et le suivi du traitement." Journal of Neuroradiology 44, no. 2 (March 2017): 99. http://dx.doi.org/10.1016/j.neurad.2017.01.061.

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Tabize Olivier, Mutendela, Freddy Munyololo Muganza, Leshweni Jeremia Shai, and Stanley Sechene Gololo. "Rutin Inhibits F, G, N and O gonorrhea strains, 2008 WHO N-gonorrhea Reference strains, in vitro." Interdisciplinary Research Journal and Archives 1 (December 16, 2020): 41–49. http://dx.doi.org/10.36966/irjar2020.13.

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Rutin was isolated from methanol extract of the aerial part of Asparagus suaveolens using precipitation method. South Africans use Asparagus suaveolens to treat gonorrhea infections. The obtained Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectroscopy (LC-MS) data and visiting the published data on the isolation of rutin confirmed the structure. The 2008 WHO Neisseria gonorrhea reference strains were used to evaluate microbial activity of rutin against the gonorrhea strains. Rutin found to be bacteriostatic against WHO 2008 Neisseria gonorrhoea F, G, N and O strains with the minimum inhibition concentration of 0.40, 0.65, 0.22 and 0.65 mg/ml, respectively. In addition, rutin fare better than the reference drugs and bactericidal against K, L, M, and P strains. These results support the traditional use of Asparagus suaveolens against gonorrhea infections by South African indigenous people. To our knowledge, this is the first study indicating the activity of rutin against N.gonorrhea strains. Résumé: La rutine a été isolée à partir d'un extrait au méthanol de la partie aérienne d'Asparagus suaveolens en utilisant la méthode de précipitation. Les SudAfricains utilisent Asparagus suaveolens pour traiter les infections gonorrhées. Les données obtenues par résonance magnétique nucléaire (RMN) et par chromatographie liquide-spectroscopie de masse (LCMS) et la consultation des données publiées sur l'isolement de la rutine ont confirmé la structure. Les souches de référence OMS de Neisseria gonorrhea de 2008 ont été utilisées pour évaluer l'activité microbienne de la rutine contre les souches de gonorrhée. La rutine s'est révélée bactériostatique contre les souches de Neisseria gonorrhea F, G, N et O de l'OMS 2008 avec une concentration minimale d'inhibition de 0,40, 0,65, 0,22 et 0,65 mg/ml, respectivement. De plus, la rutine se porte mieux que les médicaments de référence et bactéricide contre les souches K, L, M et P. Ces résultats soutiennent l'utilisation traditionnelle d'Asparagus suaveolens contre les infections gonorrhées par les populations autochtones sud-africaines. À notre connaissance, il s'agit de la première étude indiquant l'activité de la rutine contre les souches de N. gonorrhée.

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García-Mateos, Rosario, Rafael Pérez- Pacheco, Cesáreo Rodríguez-Hernández, and Marcos Soto-Hernández. "TOXICIDAD DE ALCALOIDES DE Erythrina americana EN LARVAS DE MOSQUITO Culex quinquefasciatus." Revista Fitotecnia Mexicana 27, no. 4 (July 27, 2022): 297. http://dx.doi.org/10.35196/rfm.2004.4.297.

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Este trabajo describe el efecto de varias fracciones de alcaloides obtenidas de las semillas de Erythrina americana (Fabaceae); tales fracciones permitieron evaluar in vivo su toxicidad en larvas del mosquito Culex quinquefasciatus. La fracción de alcaloides liberados no presentó actividad, sin embargo, la fracción de alcaloides libres mostró alta toxicidad (88 % de mortalidad) en las larvas. Por cromatografía de gases acoplada a espectrometría de masas y RMN-1H se detectó, en la fracción de alcaloides liberados, la presencia de los alcaloides diénicos erisopina, erisovina y erisodina; también se identificaron los alcaloides lactónicos α y β-eritroidina en la fracción de alcaloides libres. Para la evaluación insecticida se eligieron los dos principales alcaloides presentes: erisovina y β-eritroidina. Ambos alcaloides causaron 60 % de mortalidad y una CL50 en los insectos modelo fueron de 225 y 394 mg L-1, respectivamente. Los resultados muestran que la β-eritroidina resultó ser más tóxica que la erisovina.

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Lamoureux, S., J. Vion-Dury, G. Michel, S. Confort-Gouny, A. M. Salvan, B. Chabrol, I. Thuret, H. Perrimond, and P. J. Cozzone. "Anomalies neurochimiques détectées in vivo par spectroscopie localisée de résonance magnétique dans les encéphalophaties progressives liées au VIH-1 chez l'enfant." Archives de Pédiatrie 2, no. 9 (September 1995): 913. http://dx.doi.org/10.1016/0929-693x(95)90473-g.

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Tshiamala, Kabula, Joël Vebrel, and Bernard Laude. "Utilisation de la spectroscopie RMN 1H à haut champ pour la détermination de la configuration et de la conformation des cycloadduits obtenus par action de diphenylnitrilimine sur divers dihydro-1,2 naphtalenes substitués en 1." Spectrochimica Acta Part A: Molecular Spectroscopy 41, no. 3 (1985): 499–503. http://dx.doi.org/10.1016/0584-8539(85)80158-6.

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Dell’Anno, Irene, Marcella Barbarino, Elisa Barone, Antonio Giordano, Luca Luzzi, Maria Bottaro, Loredana Migliore, et al. "EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma." International Journal of Molecular Sciences 21, no. 14 (July 9, 2020): 4856. http://dx.doi.org/10.3390/ijms21144856.

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For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ascertain whether they are truly mesothelial cancer driver genes (CDGs) or genes overexpressed in an adaptive response to the tumoral progression (“passenger genes”). Through a fast siRNA-based screening, we evaluated the consequences of gene depletion on migration, proliferation, colony formation capabilities, and caspase activities of four MPM (Mero-14, Mero-25, IST-Mes2, and NCI-H28) and one SV40-immortalized mesothelial cell line (MeT-5A) as a non-malignant model. The depletion of EIF4G1 and RAN significantly reduced cell proliferation and colony formation and increased caspase activity. In particular, the findings for RAN resemble those observed for other types of cancer. Thus, we evaluated the in vitro effects of importazole (IPZ), a small molecule inhibitor of the interaction between RAN and importin-β. We showed that IPZ could have effects similar to those observed following RAN gene silencing. We also found that primary cell lines from one out of three MPM patients were sensitive to IPZ. As EIF4G1 and RAN deserve further investigation with additional in vitro and in vivo studies, they emerged as promising CDGs, suggesting that their upregulation could play a role in mesothelial tumorigenesis and aggressiveness. Furthermore, present data propose the molecular pathways dependent on RAN as a putative pharmacological target for MPM patients in the view of a future personalized medicine.

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Lanza, P. L., V. Rossi, R. Bonofiglio, W. Auteri, A. Armentano, and G. Santoro. "Sindrome da anticorpi antifosfolipidi (APA)." Rivista di Neuroradiologia 8, no. 4 (August 1995): 523–29. http://dx.doi.org/10.1177/197140099500800406.

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Gli anticorpi antifosfolipidi (APA) sono una classe eterogenea di immunoglobuline rivolte contro i fosfolipidi a carica negativa; in vitro, paradossalmente, svolgono azione anticoagulante, mentre in vivo, si associano a fenomeni trombo-embolici, spesso ricorrenti, arteriosi e/o venosi interessanti vari distretti: coronarico, cutaneo, placentare, polmonare, venoso profondo e cerebrale. Gli APA possono riscontrarsi in corso di patologie autoimmuni come il Lupus eritematusus sistemico, di infezioni, di neoplasie o dopo assunzione di farmaci; quando invece, tali situazioni morbose di base vengono escluse, essi caratterizzano la sindrome da anticorpi antifosfolipidi primitiva. Nel nostro lavoro presentiamo i casi di due giovani donne, che rientrano pienamente nei criteri diagnostici di tale sindrome: in particolare si analizzano le complicanze neurologiche e i reperti TC ed RMN cerebrali che mostrano l'associazione con fenomeni ischemici e trombosi dei seni venosi. In una delle pazienti le manifestazioni neurologiche si associano a Livedo Reticularis: tale forma di sindrome da anticorpi antifosfolipidi primitiva, è conosciuta con l'eponimo di Sneddon's syndrome. In definitiva lo scopo del nostro contributo è quello di individuare il profilo clinico e neuroradiologico che può condurre al sospetto di tale patologia.

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Carton, L., F. Auger, N. Durieux, M. Petrault, J. Labreuche, D. Allorge, O. Cottencin, N. Simon, R. Bordet, and B. Rolland. "Effet longitudinal d’une administration aiguë d’éthanol sur le GABA et le glutamate : une étude en spectroscopie par résonance magnétique in vivo chez le rat." European Psychiatry 30, S2 (November 2015): S116. http://dx.doi.org/10.1016/j.eurpsy.2015.09.222.

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IntroductionLes effets cliniques de l’intoxication alcoolique aiguë seraient liés à une modulation des systèmes de neurotransmission du GABA et du glutamate. Les caractéristiques longitudinales de cette modulation et l’impact de la dose d’éthanol absorbée restent mal connus. Nous avons voulu étudier in vivo les effets aigus de l’éthanol sur les niveaux de GABA et de glutamate du cortex préfrontal en spectroscopie par résonance magnétique (SRM).Matériel et méthodesAprès une première acquisition de SRM (zone préfrontale), trois groupes de rats Wistar mâles (363 ± 27 g) ont reçu par voie intrapéritonéale (IP) :– éthanol 1 g/kg (n = 6) ;– éthanol 2 g/kg (n = 8) ;– sérum physiologique (n = 5).Des acquisitions répétées de SRM ont été réalisées jusque 300 minutes post-injection. Une cinétique de l’éthanolémie a également été réalisée dans des groupes similaires de rats Wistar. Après alcoolisation par voie IP, des prélèvements sanguins successifs ont été réalisés jusque 180 minutes pour le groupe 1 g/kg (n = 6) et 300 minutes pour le groupe 2 g/kg (n = 14). Pour la SRM, des analyses statistiques inter- et intragroupes ont été effectuées à l’aide d’un modèle linéaire mixte visant à étudier la variation des taux de GABA et glutamate.RésultatsLa cinétique de l’éthanolémie était superposable à celle de la cinétique cérébrale. En SRM, une diminution significative du GABA, de 11,4 % ± 3,8 % (p < 0,0059) dans le groupe 1 g/kg et du glutamate de 13,8 % ± 2,6 % dans le groupe 2 g/kg (p < 0,0001) ont été observées, sans modification significative dans les autres groupes. La variation du ratio GABA/glutamate s’est montrée différente entre les deux groupes éthanol avec une augmentation dans le groupe 2 g/kg et une diminution dans le groupe 1 g/kg (p < 0,01).ConclusionLa dose d’éthanol détermine les variations des niveaux de GABA et de glutamate du cortex préfrontal, pouvant expliquer les différents effets cliniques induits par l’alcool selon la dose.

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Furesi, Giulia, Antonio Miguel de Jesus Domingues, Dimitra Alexopoulou, Andreas Dahl, Matthias Hackl, Johannes R. Schmidt, Stefan Kalkhof, et al. "Exosomal miRNAs from Prostate Cancer Impair Osteoblast Function in Mice." International Journal of Molecular Sciences 23, no. 3 (January 24, 2022): 1285. http://dx.doi.org/10.3390/ijms23031285.

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Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone metastases. Characteristically, PCa causes osteosclerotic lesions as a result of disrupted bone remodeling. Extracellular vesicles (EVs) participate in PCa progression by conditioning the pre-metastatic niche. However, how EVs mediate the cross-talk between PCa cells and osteoprogenitors in the bone microenvironment remains poorly understood. We found that EVs derived from murine PCa cell line RM1-BM increased metabolic activity, vitality, and cell proliferation of osteoblast precursors by >60%, while significantly impairing mineral deposition (−37%). The latter was further confirmed in two complementary in vivo models of ossification. Accordingly, gene and protein set enrichments of osteoprogenitors exposed to EVs displayed significant downregulation of osteogenic markers and upregulation of proinflammatory factors. Additionally, transcriptomic profiling of PCa-EVs revealed the abundance of three microRNAs, miR-26a-5p, miR-27a-3p, and miR-30e-5p involved in the suppression of BMP-2-induced osteogenesis in vivo, suggesting the critical role of these EV-derived miRNAs in PCa-mediated suppression of osteoblast activity. Taken together, our results indicate the importance of EV cargo in cancer-bone cross-talk in vitro and in vivo and suggest that exosomal miRNAs may contribute to the onset of osteosclerotic bone lesions in PCa.

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Beauvieux, M., J. Naulin, G. Raffard, D. Sampol, A. Bouzier-Sore, H. Gin, and J. Gallis. "P214 Le fructose alimentaire favorise l’insulino-résistance et induit rapidement des modifications cérébrales microstructurales : étude in vivo par RMN (IRM et DTI) chez le rat en croissance." Diabetes & Metabolism 40 (March 2014): A79. http://dx.doi.org/10.1016/s1262-3636(14)72505-4.

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He, Qiangqiang, Ji Ma, Praveen Kumar Kalavagunta, Liangliang Zhou, Junyi Zhu, Jing Dong, Owais Ahmad, Yuzhi Du, Lixin Wei, and Jing Shang. "HgS Inhibits Oxidative Stress Caused by Hypoxia through Regulation of 5-HT Metabolism Pathway." International Journal of Molecular Sciences 20, no. 6 (March 18, 2019): 1364. http://dx.doi.org/10.3390/ijms20061364.

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This study aims to reveal the potential relationship between 5-HT and oxidative stress in the organism. Our in vitro experiments in RIN-14B cells showed that anoxia leads the cells to the state of oxidative stress. Administration of exogenous 5-HT exacerbated this effect, whereas the inhibition of Tph1, LP533401 alleviated the oxidative stress. Several research articles reported that Cinnabar (consists of more than 96% mercury sulfide, HgS), which is widely used in both Chinese and Indian traditional medicine prescriptions, has been involved in the regulation of 5-HT. The present research revealed that HgS relieved the level of oxidative stress of RIN-14B cells. This pharmacological activity was also observed in the prescription drug Zuotai, in which HgS accounts for 54.5%, and these effects were found to be similar to LP533401, an experimental drug to treat pulmonary hypertension. Further, our in vivo experiments revealed that the administration of cinnabar or prescription drug Zuotai in zebrafish reduced the reactive oxygen species (ROS) induced by hypoxia and cured behavioral abnormalities. Taken together, in organisms with hypoxia induced oxidative stress 5-HT levels were found to be abnormally elevated, indicating that 5-HT could regulate oxidative stress, and the decrease in the 5-HT levels, behavioral abnormalities after treatment with cinnabar and Zuotai, we may conclude that the therapeutic and pharmacologic effect of cinnabar and Zuotai may be based on the regulation of 5-HT metabolism and relief of oxidative stress. Even though they aren’t toxic at the present dosage in both cell lines and zebrafish, their dose dependent toxicities are yet to be evaluated.

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Assan Aliyar, Meharban, Pratibha Nadig, and Nagakumar Bharatham. "In vitro anti-diabetic activity, bioactive constituents, and molecular modeling studies with sulfonylurea receptor1 for insulin secretagogue activity of seed extract of Syzygium cumini (L.)." Journal of Herbmed Pharmacology 10, no. 3 (July 2, 2021): 304–12. http://dx.doi.org/10.34172/jhp.2021.35.

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Introduction: Syzygium cumini (L.) has been known to be used for diabetes treatment in traditional Indian and Chinese medicine. The present study focuses on the evaluation for glucose uptake and insulin release in vitro and characterization of phytoconstituents of the hydro-ethanolic extract of Syzygium cumini seed (SCE). Further, this report covers the molecular docking findings of the bioactive constituents on the sulfonylurea receptor 1 (SUR1). Methods: A glucose uptake assay of SCE was used to estimate the glucose uptake from the cell lysates and the cell culture supernatants using insulin as the reference standard. Insulin release activity of SCE from RIN-5F cells was estimated using enzyme-linked immunosorbent assay. The phytoconstituents were isolated by preparative HPLC and characterized by mass spectrometry, nuclear magnetic resonance (NMR) and infrared spectroscopy. The molecular docking of bioactive constituents was carried on repaglinide bound to the SUR1. Results: In the presence of SCE, the glucose uptake through L6 myoblast cells increased by 19.91% at 40 µg/mL in comparison with the vehicle control (P < 0.05). Moreover, SCE showed 2.8-fold enhancement of insulin release at 40 µg/mL as compared to the vehicle controls (P < 0.05). Gallic and ellagic acids were the key phytoconstituents isolated from SCE. Molecular docking studies revealed that both gallic acid and ellagic acid bind to the repaglinide binding pocket of SUR1. Conclusion: SCE increases the release of insulin and enhances glucose uptake in vitro, which may contribute to its in vivo anti-diabetic activity. The presence of ellagic acid and gallic acid in SCE may be the cause for enhanced insulin release observed with SCE following binding to SUR1.

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Mani, Vimalraj, Chinreddy Subramanyam Reddy, Seon-Kyeong Lee, Soyoung Park, Hyoung-Rai Ko, Dong-Gwan Kim, and Bum-Soo Hahn. "Chitin Biosynthesis Inhibition of Meloidogyne incognita by RNAi-Mediated Gene Silencing Increases Resistance to Transgenic Tobacco Plants." International Journal of Molecular Sciences 21, no. 18 (September 10, 2020): 6626. http://dx.doi.org/10.3390/ijms21186626.

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Meloidogyne incognita is a devastating plant parasitic nematode that causes root knot disease in a wide range of plants. In the present study, we investigated host-induced RNA interference (RNAi) gene silencing of chitin biosynthesis pathway genes (chitin synthase, glucose-6-phosphate isomerase, and trehalase) in transgenic tobacco plants. To develop an RNAi vector, ubiquitin (UBQ1) promoter was directly cloned, and to generate an RNAi construct, expression of three genes was suppressed using the GATEWAY system. Further, transgenic Nicotiana benthamiana lines expressing dsRNA for chitin synthase (CS), glucose-6-phosphate isomerase (GPI), and trehalase 1 (TH1) were generated. Quantitative PCR analysis confirmed endogenous mRNA expression of root knot nematode (RKN) and revealed that all three genes were more highly expressed in the female stage than in eggs and in the parasitic stage. In vivo, transformed roots were challenged with M. incognita. The number of eggs and root knots were significantly decreased by 60–90% in RNAi transgenic lines. As evident, root galls obtained from transgenic RNAi lines exhibited 0.01- to 0.70-fold downregulation of transcript levels of targeted genes compared with galls isolated from control plants. Furthermore, phenotypic characteristics such as female size and width were also marginally altered, while effect of egg mass per egg number in RNAi transgenic lines was reduced. These results indicate the relevance and significance of targeting chitin biosynthesis genes during the nematode lifespan. Overall, our results suggest that further developments in RNAi efficiency in commercially valued crops can be applied to employ RNAi against other plant parasitic nematodes.

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Ulyanova, Vera, Raihan Shah Mahmud, Alexander Laikov, Elena Dudkina, Maria Markelova, Ahmed Mostafa, Stephan Pleschka, and Olga Ilinskaya. "Anti-Influenza Activity of the Ribonuclease Binase: Cellular Targets Detected by Quantitative Proteomics." International Journal of Molecular Sciences 21, no. 21 (November 5, 2020): 8294. http://dx.doi.org/10.3390/ijms21218294.

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Unpredictable influenza pandemics, annual epidemics, and sporadic poultry-to-human avian influenza virus infections with high morbidity and mortality rates dictate a need to develop new antiviral approaches. Targeting cellular pathways and processes is a promising antiviral strategy shown to be effective regardless of viral subtypes or viral evolution of drug-resistant variants. Proteomics-based searches provide a tool to reveal the druggable stages of the virus life cycle and to understand the putative antiviral mode of action of the drug(s). Ribonucleases (RNases) of different origins not only demonstrate antiviral effects that are mediated by the direct RNase action on viral and cellular RNAs but can also exert their impact by signal transduction modulation. To our knowledge, studies of the RNase-affected cell proteome have not yet been performed. To reveal cellular targets and explain the mechanisms underlying the antiviral effect employed by the small extra-cellular ribonuclease of Bacillus pumilus (binase) both in vitro and in vivo, qualitative shotgun and quantitative targeted proteomic analyses of the influenza A virus (IAV) H1N1pdm09-infected A549 cells upon binase treatment were performed. We compared proteomes of mock-treated, binase-treated, virus-infected, and virus-infected binase-treated cells to determine the proteins affected by IAV and/or binase. In general, IAV demonstrated a downregulating strategy towards cellular proteins, while binase had an upregulating effect. With the help of bioinformatics approaches, coregulated cellular protein sets were defined and assigned to their biological function; a possible interconnection with the progression of viral infection was conferred. Most of the proteins downregulated by IAV (e.g., AKR1B1, AKR1C1, CCL5, PFN1, RAN, S100A4, etc.) belong to the processes of cellular metabolism, response to stimulus, biological regulation, and cellular localization. Upregulated proteins upon the binase treatment (e.g., AKR1B10, CAP1, HNRNPA2B1, PFN1, PPIA, YWHAB, etc.) are united by the processes of biological regulation, cellular localization, and immune and metabolic processes. The antiviral activity of binase against IAV was expressed by the inversion of virus-induced proteomic changes, resulting in the inhibition of virus-associated processes, including nuclear ribonucleoprotein export (NCL, NPM1, Nup205, and Bax proteins involved) and cytoskeleton remodeling (RDX, PFN1, and TUBB) induced by IAV at the middle stage of single-cycle infection in A549 cells. Modulation of the immune response could be involved as well. Overall, it seems possible that binase exerts its antiviral effects in multiple ways.

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Guo, Yugang, Qianwen Xu, Lei Xue, Erling Chen, Chonglin Liu, Min Gao, Youjia Li, et al. "Abstract LB236: Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses." Cancer Research 84, no. 7_Supplement (April 5, 2024): LB236. http://dx.doi.org/10.1158/1538-7445.am2024-lb236.

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Abstract Background: The undeniable success of CD19 CAR-T cell therapy in managing relapsed or refractory (r/r) B-cell hematological malignancies, such as diffuse large B-cell lymphoma (DLBCL) and B-cell acute lymphoblastic leukemia (B-ALL), underscores its significance. Despite the favorable complete remission (CR) rates of around 50% for r/r DLBCL and up to 90% for r/r B-ALL, a notable challenge persists as more than half of patients experiencing CR after CD19 CAR-T cells treatment encounter relapse within a year, attributed to inadequate CAR-T persistence in both indications. Urgent attention is required to devise innovative strategies to overcome these challenges. Recently, we developed metabolically armed CD19 CAR-T cells expressing IL-10 can enhance OXPHOS metabolism, proliferation, and persistence of CAR-T cells in vivo. Significantly, these IL-10-expressing CAR-T cells trigger stem-like memory responses in various lymphoid organs, leading to robust tumor eradication and durable protection. Motivated by these promising findings, an open-label, single arm, investigator-initiated trial (IIT, ClinicalTrials.gov identifier: NCT05715606, NCT05747157) was conducted to assess the safety and efficacy of newly developed metabolically armed IL-10-expressing CD19 CAR-T (product name: Meta10-19 infusion) for treating patients with r/r DLBCL or r/r B-ALL. Method: From Feb 2023 to Dec 2023, this IIT clinical trial evaluated Meta10-19 infusion in adult patients with r/r DLBCL or r/r B-ALL. The patients were recruited and treated at the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China. Patients in 3 dose cohorts (2.0 × 104, 5.0 × 104, or 1.0 × 105 CAR-T cells/kg, corresponding to 1%, 2.5%, or 5% doses of commercialized CAR-T infusion) underwent lymphodepleting chemotherapy with cyclophosphamide and fludarabine before Meta10-19 infusion. The primary endpoint was the incidence of dose-limiting toxicities. The secondary endpoint was the response and survival. Results: The treatment with Meta10-19 infusion has successfully induced CR in all 12 cases of r/r DLBCL (n=6) or r/r B-ALL (n=6), as evaluated by PET-CT scan, NMR spectroscopy or minimal residual disease assessment of bone marrow. No server cytokine storm syndrome or neurotoxicity was observed. All treated patients achieved CR at 3 months post treatment, with the first patient maintaining continuous remission up to 9 months until now. Notably, these metabolically armed CD19 CAR-T cells demonstrated efficacy even for patients with bulky mass (≥7.5 cm) of DLBCL at extremely low infusion dose (1~5% doses of commercialized CAR-T). Conclusion: Preliminary findings suggest that Meta10-19 infusion exhibits promising breakthrough efficacy and safety profile, and active enrollment is ongoing to validate the initial results. Citation Format: Yugang Guo, Qianwen Xu, Lei Xue, Erling Chen, Chonglin Liu, Min Gao, Youjia Li, Jingjing Ren, Jinping Li, Li Tang, Xingbing Wang. Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB236.

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Huegl, B., M. Kreuzer, Z. Doneva, S. T. Mirazchiyski, and B. Buchter. "Bipolar ablation: first in man using combined robotic magnetic navigation with a manual approach in a complex pvc case." Europace 25, Supplement_1 (May 24, 2023). http://dx.doi.org/10.1093/europace/euad122.715.

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Abstract Funding Acknowledgements Type of funding sources: None. Background Standard unipolar catheter ablation (UPA) with radiofrequency for ventricular arrhythmias has reportedly recurrence rates due to a lack of efficient lesions in the deep myocardial substrates to disrupt the critical components of the arrhythmia circuit. First in-vivo bipolar catheter ablations (BPA) show promising results to counter this issue. Precise handling of two catheters simultaneously during BPA is a challenge that the utilization of a robotic magnetic navigation (RMN) system could make safer by robotically controlling one of the catheters. Method A RMN ablation catheter with a 3.5 mm irrigated tip (RMN Navistar Thermocool, Biosense Webster), as an active catheter, as well as an indifferent manual catheter 3.5 mm irrigated non-nav ablation catheter (Celsius Thermocool, Biosense Webster) was connected to a BPA-certified generator system (HAT 500® system (OSYPKA, Germany)). The RMN catheter was controlled by a RMN Stereotaxis- system. A 3D Carto system combined with a VIVO system was used to find the right localization. Results 70-year-old male with ischemic CMP, EF nearly 40%, revascularized through CABG, presented after 4 attempts of ablation of very frequent symptomatic monomorphic PVCs (more than 30000 /24h), with different approaches in different hospitals. The origin of PVCs was mid-septal RV/LV. After LAT Mapping in a transseptal approach with the RMN Catheter (LV), the manual catheter was placed at the opposite site in the RV. Bipolar Ablation was done at 30W (3 min) with acute suppression of the PVCs. The follow-up duration was 6-months with still lasting good result. No complications occurred. Conclusions BPA ablation is an additional energy option in difficult cases. With a RMN system is it feasible and safe. The robotic control of one of the two ablation catheters provides a precise and stable execution of the BPA since the operator only needs to control the second catheter manually while the magnetic field holds the first in place. It therefore also allows a single operator approach.

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"Association familiale hyperthermie maligne et syndrome malin des neuroleptiques. Investigation par les tests de contractures et la spectroscopie RMN P31." Annales Françaises d'Anesthésie et de Réanimation 9 (January 1990): R120. http://dx.doi.org/10.1016/s0750-7658(05)82129-x.

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Carlos Rueda, Juan, and Sehila Jiménez Mayanga. "SINTESIS Y CARACTERIZACION DE NUEVOS MACROMONOMEROS DE 2-OXAZOLINAS OBTENIDOS POR EL METODO DEL TERMINADOR." Revista de la Sociedad Química del Perú 89, no. 2 (June 30, 2023). http://dx.doi.org/10.37761/rsqp.v89i2.432.

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Se sintetizaron nuevos macromonómeros de 2-oxazolinas a partir de la polimerización catiónica por apertura de anillo de la 2-etil-2-oxazolina o de la 2-metoxicarboniletil-2-oxazolina obteniéndose los macromonómeros M1 y M2, respectivamente. La polimerización se llevó a cabo en acetonitrilo a 78°C y fue iniciada por el triflato de metilo y terminada por la N-(4-vinilbencil)-piperazina (método del terminador).Los macromonómeros fueron caracterizados mediante resonancia magnética nuclear de protones (1H-RMN), espectrometría infrarroja y ultravioleta/visible. Se determinó mediante el análisis cuantitativo de los espectros 1H-RMN que los grados de polimerización de los macromonómeros M1 y M2 fueron de 14 (peso molecular 1605 g/mol) y 12 unidades (peso molecular 2100 g/mol), respectivamente, concordando muy bien estos valores experimentales con los valores teóricos (15 y 12). Este hecho fue evidencia de que la polimerización fue de carácter “vivo” y que transcurrió sin reacciones secundarias tales como reacciones de terminación o de transferencia de cadena.

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Bhuyan, Biman, and Dipak Chetia. "Caracterización de compuestos antidiabéticos potentes de Costus pictus D. Don encontrados en Assam, India usando métodos in vitro e in vivo." Ars Pharmaceutica (Internet) 60, no. 1 (March 12, 2019). http://dx.doi.org/10.30827/ars.v60i1.7692.

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Objetivo: Costus pictus D. Don es una planta usada tradicionalmente en la zona del distrito de Golaghat Naojan de Assam, India específicamente para el tratamiento de la diabetes. Seis compuestos se aislaron a partir de extracto metanólico estandarizados de las hojas (MECP). El principal objetivo fue seleccionar compuestos antidiabéticos más potentes entre los compuestos aislados viz. F67, F12, F16, F3032, F37 y F48 mediante métodos in vitro e in vivo. Métodos: Los compuestos aislados fueron sometidos a cribado inicial mediante ensayo de actividad de inhibición in vitro α-amilasa utilizando yodo-almidón y métodos DNSA (ácido 3,5-dinitrosalicilico). Los compuestos que presentaban una actividad in vitro prometedora se seleccionaron para la actividad de cribado antidiabético inducida por estreptozotocina (STZ) in vivo. En función de los resultados in vivo, la mayoría de los compuestos potentes se seleccionaron para la caracterización instrumental por Q-TOF ESI-MS, 1HNMR, 13CNMR y FTIR. Resultados: Entre los seis compuestos aislados de MECP, tres compuestos viz. F12, F16 y F48 mostraron una potente actividad. Posteriormente se sometieron a evaluación de la actividad antidiabética in vivo mediante administración oral, en dosis de 10, 20 y 50 mg / kg peso, utilizando ratas Wister (120-150 g) y glibenclamida (10 mg / kg peso) como estándar. Dos compuestos, F12 y F48 en dosis de 50 mg/kg peso, revirtieron los parámetros diabéticos inducidos por STZ (aumento del nivel de glucosa en sangre, plasma perfil alterado y histoarquitectura del páncreas y células hepáticas), con significación estadística (P<0,05) que era comparable con la norma. Se llevo a cabo la caracterización instrumental por Q-TOF ESI-MS, RMN 1H, RMN 13C y FTIR de los compuestos F12 y F48 aislado de MECP, lo que estableció su identidad como (3,5,7-trihidroxi-3 ‘-hidroxi-4’- metoxi) flavanona o [3,5,7-trihidroxi-2- (fenil 3 ‘-hidroxi-4’-metoxi) -2,3-dihydrochromen-4-ona] y 3,5,8-trihidroxi-7-metoxi -2-fenil-2,3-dihydrochromen-4-ona o [7-metoxi-3, 5, 8 trihidroxi flavanona] respectivamente. Conclusión: El estudio culminó en la elucidación de dos flavanonas como los compuestos más potentes en la exposición de actividades antidiabéticas. Los resultados lograron validar las prácticas tradicionales en el distrito de Golaghat de Assam, India, asociados con el uso de Costus pictus D. Don en el tratamiento de la diabetes.

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Abdou Khadir Fall, Serigne, Hassane Faraj, Anouar Alami, Saïd Achamlale, and Younas Aouine. "Synthèse Et Caractérisation De La Structure Du [{4-[(1HBenzo[D]Imidazol-1-Yl)Méthyl]- 1H-1,2,3-Triazol-1 Yl}(Benzamido)Méthyl]Phospho nate De Diéthyle Par La Spectroscopie RMN 1D Et 2D." European Scientific Journal ESJ 16, no. 36 (December 31, 2020). http://dx.doi.org/10.19044/esj.2020.v16n36p314.

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"Analyse histologique in vivo en temps réel des polypes colorectaux grâce à une pince à biopsie “optique” basée sur la spectroscopie de fluorescence induite par laser." Endoscopy 48, no. 06 (May 30, 2016): 603–4. http://dx.doi.org/10.1055/s-0042-108247.

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