Добірка наукової літератури з теми "Spatio-temporal Regulators"
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Статті в журналах з теми "Spatio-temporal Regulators"
Fritz, Rafael Dominik, and Olivier Pertz. "The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns." F1000Research 5 (April 26, 2016): 749. http://dx.doi.org/10.12688/f1000research.7370.1.
Повний текст джерелаBakhsh, A., K. Shahzad, and T. Husnain. "Variation in the spatio-temporal expression of insecticidal genes in cotton." Czech Journal of Genetics and Plant Breeding 47, No. 1 (March 18, 2011): 1–9. http://dx.doi.org/10.17221/131/2010-cjgpb.
Повний текст джерелаHill, Robert E., and Laura A. Lettice. "Alterations to the remote control of Shh gene expression cause congenital abnormalities." Philosophical Transactions of the Royal Society B: Biological Sciences 368, no. 1620 (June 19, 2013): 20120357. http://dx.doi.org/10.1098/rstb.2012.0357.
Повний текст джерелаSun, Shuo, Changyu Yi, Jing Ma, Shoudong Wang, Marta Peirats-Llobet, Mathew G. Lewsey, James Whelan, and Huixia Shou. "Analysis of Spatio-Temporal Transcriptome Profiles of Soybean (Glycine max) Tissues during Early Seed Development." International Journal of Molecular Sciences 21, no. 20 (October 14, 2020): 7603. http://dx.doi.org/10.3390/ijms21207603.
Повний текст джерелаPintard, Lionel, and Vincent Archambault. "A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key." Open Biology 8, no. 8 (August 2018): 180114. http://dx.doi.org/10.1098/rsob.180114.
Повний текст джерелаPang, Junling, Xia Zhang, Xuhui Ma, and Jun Zhao. "Spatio-Temporal Transcriptional Dynamics of Maize Long Non-Coding RNAs Responsive to Drought Stress." Genes 10, no. 2 (February 13, 2019): 138. http://dx.doi.org/10.3390/genes10020138.
Повний текст джерелаWarmerdam, Daniël O., Roland Kanaar, and Veronique A. J. Smits. "Differential Dynamics of ATR-Mediated Checkpoint Regulators." Journal of Nucleic Acids 2010 (2010): 1–16. http://dx.doi.org/10.4061/2010/319142.
Повний текст джерелаShan, Xiaotong, Yueqing Li, Song Yang, Zhongzhou Yang, Meng Qiu, Ruifang Gao, Taotao Han, et al. "The spatio‐temporal biosynthesis of floral flavonols is controlled by differential phylogenetic MYB regulators in Freesia hybrida." New Phytologist 228, no. 6 (August 18, 2020): 1864–79. http://dx.doi.org/10.1111/nph.16818.
Повний текст джерелаBotti, Gerardo, Clemente Cillo, Rossella De Cecio, Maria Gabriella Malzone, and Monica Cantile. "Paralogous HOX13 Genes in Human Cancers." Cancers 11, no. 5 (May 20, 2019): 699. http://dx.doi.org/10.3390/cancers11050699.
Повний текст джерелаGao, Yuanhui, Hui Cao, Denggao Huang, Linlin Zheng, Zhenyu Nie, and Shufang Zhang. "RNA-Binding Proteins in Bladder Cancer." Cancers 15, no. 4 (February 10, 2023): 1150. http://dx.doi.org/10.3390/cancers15041150.
Повний текст джерелаДисертації з теми "Spatio-temporal Regulators"
Mitchell, Elaine Irwin. "Spatio-temporal modelling of gene regulatory networks." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/259d76f6-76cf-474d-a26a-2802808b126e.
Повний текст джерелаSturrock, Marc. "Spatio-temporal modelling of gene regulatory networks containing negative feedback loops." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/b824506e-d515-442a-b9dc-ff82568f3c09.
Повний текст джерелаCiardo, Diletta. "Quantitative analysis of the regulation of the DNA replication program by the intra-S phase checkpoint in Xenopus embryos Checkpoint control of the spatio-temporal regulation of DNA replication in Xenopus early embryos Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway Genome wide decrease of DNA replication eye density at the midblastula transition of Xenopus laevis Polo like kinase 1 promotes dispersed replication origin firing during S phase." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS478.
Повний текст джерелаThe initiation of DNA replication in multicellular organisms starts from several thousand genomic loci called replication origins. They are grouped into domains which replicate early or late during S phase. The firing of a replication origin creates two diverging replication forks that replicate flanking DNA. One of the mechanisms regulating DNA replication program is the ATR/Chk1 dependent intra-S phase checkpoint. This pathway is activated by replicative stress due to stalled replication forks at early firing origins and in turn, inhibits the late firing of origins. It has been proposed that the checkpoint recovery kinase Plk1 (Polo-Like-Kinase 1) could be responsible for allowing origin firing close to stalled forks in replication stress conditions. However, origin firing has not been analysed after Plk1 inhibition or depletion during unperturbed S phase. To assemble a comprehensive and unified view of the DNA replication process numerical and analytical models have been built in the past, but none of them integrates the role of checkpoint pathways. The goal of my thesis was to investigate experimentally and analytically how the checkpoint regulates the firing of origins in space and time and, in particular, whether the Plk1 is implicated in the regulation of origin firing during unperturbed S phase. To this end, I used the Xenopus in vitro system. First, I integrated in a numerical model the checkpoint pathway to describe the replication program in the Xenopus in vitro system. I tested different scenarios and used DNA combing data previously obtained by the laboratory after the inhibition of the checkpoint kinase Chk1. Monte Carlo simulated data were fitted to experimental data by optimizing the values of free parameters of models using a genetic algorithm. I found that two new hypothesis should be added to formerly built replication models: 1) a strong inhibition of origin firing by Chk1 from the beginning of S phase 2) the presence of early replicating genomic domains that evade the origin firing inhibition. Second, I experimentally showed that during unperturbed S phase active Plk1 is recruited to chromatin before the start of S phase and that in the absence of Plk1, DNA replication is slowed down. Moreover, Plk1 depletion led to an increase in Chk1 phosphorylation (p-Chk1) and a decrease of Cdk2 activity, suggesting that Plk1 inhibits the intra-S phase checkpoint. Performing DNA combing, I demonstrated that Plk1 depletion leads to a decrease in origin firing level. Analysis of the combing data by the developed numerical model suggested that during unchallenged S phase Plk1 down regulates the global origin firing inhibitory action of Chk1, consistent with the experimental observation of increased level of p-Chk1 in Plk1 depleted Xenopus egg extract. However, Plk1 does not seem to act close to replication forks as was proposed earlier. Finally, by considering replication process as a one-dimensional nucleation and growth process and using statistical methods, I developed a new quantitative approach to study the regulation of replication program. This approach links the similarity between single molecule replication patterns to DNA replication regulating processes. By analyzing DNA combing data, I showed that DNA replication program in Xenopus early embryos is regulated by two spatially and temporally exclusive processes. One with low frequency of origin firing and high apparent fork speed and a second, controlled by PlK1, with a high frequency of origin firing and a low apparent fork speed. Altogether my results demonstrate that Plk1 positively regulates replication origin firing during normal S phase by down regulating the replication checkpoint. The numerical model predicts the existence of replication timing domains in the Xenopus model system. Future work will show whether Plk1 regulates the replication program at the level of genomic domains
Kinuthia, Wanyee. "“Accumulation by Dispossession” by the Global Extractive Industry: The Case of Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30170.
Повний текст джерелаЧастини книг з теми "Spatio-temporal Regulators"
Tissot, Cyril, Etienne Neethling, Mathias Rouan, Gérard Barbeau, Hervé Quénol, and Céline Le Coq. "Modeling Environmental Impacts on Viticultural Ecosystems." In Environmental Information Systems, 1403–22. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7033-2.ch063.
Повний текст джерелаJoshi, P. K., and Neena Priyanka. "Geo-Informatics for Land Use and Biodiversity Studies." In Geographic Information Systems, 1913–39. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2038-4.ch114.
Повний текст джерелаТези доповідей конференцій з теми "Spatio-temporal Regulators"
Yuan, Enpeng, and Pascal Van Hentenryck. "Real-Time Pricing Optimization for Ride-Hailing Quality of Service." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/515.
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