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Дисертації з теми "Somatomedin"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 30 липня 2024

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1

Bastian, Susan Elaine Putnam. "Transcellular transport of insulin-like growth factor-1 (IGF-1)." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phb3255.pdf.

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2

Bagley, Christopher James. "Analogues of Insulin-Like Growth Factor-1 / Christopher James Bagley." Title page, table of contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phb146.pdf.

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3

Williams, Nolann G. "Myostatin regulation of the insulin-like growth factor axis." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/n_williams_042009.pdf.

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Thesis (M.S. in genetics and cell biology)--Washington State University, May 2009.
Title from PDF title page (viewed on Apr. 5, 2010). "School of Molecular Biosciences." Includes bibliographical references (p. 39-45).

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4

Ramaswamy, Girish. "Mechanical and geometric characterization of mouse cortical bone with osteoblast-specific knockout of insulin-like growth factor receptor gene." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/ramaswamy.pdf.

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5

Diego, Vincent P. "Genotype x age interaction, and the insulin-like growth factor I axis in the San Antonio Family Heart Study a study in human senescence /." Diss., Online access via UMI:, 2005.

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6

Wilker, Erik William. "Role of insulin-like growth factor I in mouse skin tumor promotion /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3064687.

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7

Dodson, Michael Verne. "EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTORS ON SATELLITE CELL PROLIFERATION IN VITRO (SOMATOMEDINS, RECEPTORS)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188065.

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Primary cultures of skeletal muscle satellite cells were induced to proliferate by exposure to physiologic levels of somatomedins and pharmacologic levels of insulin. Dexamethasone inclusion in serum containing medium facilitated the ovine somatomedin (oSm) (P < 0.05), but that both were different than the proliferation induced by MSA/rIGF-II (P < 0.05). In the presence of insulin concentrations that promote maximum proliferation, addition of oSm did not produce an additive effect, whereas the addition of MSA/rIGF-II did produce a significant increase in satellite cell proliferation above that induced by insulin. A more, in depth, analysis of the interaction of MSA/rIGF-II with its satellite cell receptor under a variety of experimental conditions revealed that binding of ¹²⁵I-MSA/rIGF-II was inhibited by oSm and MSA/rIGF-II, but not by insulin. Migration, and localization of ¹²⁵I-MSA/rIGF-II-receptor complexes in 7% sodium dodecyl sulfate polyacrylamide gels suggest that these complexes are Type II IGF receptors. In addition, this receptor system of satellite cells was shown to be modulated by other hormones; notably, pre-exposure of cells with insulin increased ¹²⁵I-MSA/rIGF-II binding, while oSm, or MSA/rIGF-II preincubation decreased the binding of ¹²⁵I-MSA/rIGF-II. Therefore, the proliferative effects of MSA/rIGF-II appeared not as a consequence of MSA/rIGF-II induction of other receptor types such as the insulin, or Type I IGF receptor systems. Concommitant to the previous experimentation, oSm was further examined in an initial attempt to elucidate its biologic binding mechanism in myogenic satellite cells. Binding of ¹²⁵I-oSm was inhibited by MSA/rIGF-II, insulin and IGF-I; thus these data suggest that oSm may be the ovine analog to human IGF-I. In addition, pre-exposure of cells to MSA/rIGF-II and oSm down-regulated the ability of satellite cells to bind oSm, while only concentrations of insulin greater than 550 ng insulin had this ability. Collectively, these data support the hypothesis that somatomedins play an important role in the control of postnatal muscle growth by providing a link between these hormones and satellite cells, one of the significant target cells involved in the growth process.

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8

Conlon, Michael Allan. "The effects of chronic IGF-I, IGF-II on long R3 IGF-I infusion on the postnatal growth of rats and guinea pigs." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phc7518.pdf.

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9

Thornton, William H. "The role of extracellular zinc in IGF-1 receptor expression and proliferation in a normal and squamous cell carcinoma cell line." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946305.

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10

涂文偉 and Wenwei Tu. "Effects of insulin-like growth factor 1 on cord blood T cell development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31239377.

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11

Tu, Wenwei. "Effects of insulin-like growth factor 1 on cord blood T cell development /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2102893X.

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12

Walker, Gillian E. "The expression and regulation of human insulin-like growth factor-1 (IGF-1) during cellular growth, differentiation and tumourigenesis." Thesis, Queensland University of Technology, 1998. https://eprints.qut.edu.au/37002/8/37002_Digitised%20Thesis.pdf.

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Insulin-like growth factor (IGF) -I and -II play a significant role in determining a cell's fate, being involved in cellular growth and differentiation, tumourigenesis and as survival factors against apoptosis. These diverse biological actions of IGFs are mediated by their interaction with the type I IGF receptor (IGF-IR), with their availability to this receptor mediated by IGF binding proteins (IGFBPs) present within the extracellular compartments. The IGF-I and -II genes synthesise multiple mRNAs by alternate promoter usage and alternative splicing. This potentially contributes to the diverse biological actions of IGF-I and -II. The aim of this doctoral study was to establish whether the differential expression of the IGF-I mRNAs, and to a lesser extent IGF-Il mRNAs, is a mechanism which determines their particular biological function. Using the IGF-I expressing human neuroblastoma cell line SK-N-MC and the non-expressing SK-N-SH cell line, I investigated the pattern of mRNA expression of IGF-I, IGF-II, the IGF-IR and the six IGFBPs, during growth and differentiation in vitro ( +1- foetal+ bovine serum). This study has identified that the four major IGF-I mRNAs, the IGF-IR and IGFBP-2, -4, -5 and -6 are expressed by the SK-N-MC cells, while IGF-II, its Ser-29 variant and the IGF-IR mRNAs were expressed by the SK-N-SH cells. During cell growth, the expression of all four IGF-I mRNAs and the IGF-IR increased, with no change in the pattern of expression over time, suggesting that these mRNAs each have a consistent and coordinate role during cell growth. Differentiation of the SK-N-MC cells was stimulated by the removal of exogenous growth factors, marked by a change in morphology and a drop in plasminogen activator activity. Of the IGF-I mRNAs, only class I Eb was expressed at detectable levels and increased with proliferation. IGF-IR mRNA was also detected in these cells, as well as an mRNA coding for a potential novel IGF-IR mRNA lacking the cysteine binding domain in the a-subunit. A differential pattern of IGFBP expression was also observed in SK-N-MC cells grown in either a serum-containing or a serum-free environment, with IGFBP-6 expression being switched off in a serum-free environment. Surprisingly, the expression of class I Eb mRNAs and the variant IGF-IR were also detected in the negative control SKN- SH cells grown in serum-free medium. These results indicate that class 1 Eb mRNAs may have a role in differentiation, and may be regulated by the presence or absence of specific serum factor( s ). IGF expression during tumourigenesis was examined using the development and progression of breast cancer as the model system. The four major IGF-I mRNAs were expressed in normal breast tissue with their expression levels increasing in breast tumours. The four mRNAs were differentially expressed during the development and progression of the disease with class 2 mRNAs increasing relative to class 1 and Eb mRNAs increasing relative to Ea. The difference in the Class 1/Class 2 and Ea/Eb ratios were highly significant between normal and tumourigenic tissues and may provide a possible target for the early detection of malignancies. IGF-I mRNAs were found to be stromally expressed in normal breast tissue and early stage malignancies, however they were expressed by both the stroma and tumour epithelial cells in the more advanced malignancies. Like IGF-I, JGF-II was differentially expressed during the development and progression of the disease, with Ser-29 IGF-II mRNA levels increasing relative to the levels of IGF-II. Of the IGFBPs, a distinct pattern of expression was observed between normal, low and high grade ductal carcinomas. The most significant difference observed between normal breast and breast tumour progression, was the decrease in IGFBP-6 mRNA and the dramatic increase in IGFBP-4 expression levels. Overall, this doctoral study suggests that Eb mRNA expression, in combination with alternate promoter usage, exists in a fine balance. These results suggest that an upregulation of class 1 Eb expression contributes to cellular differentiation and that an over-expression of Eb mRNAs contributes to a tumourigenic phenotype. This study also suggests that there may be a differential role for the Ser-29 IGF-II variant in tumourigenesis, and that the deactivation of IGFBP-6 in concert with the upregulation of IGFBP-4, may be a precursor of malignancy. These hypotheses are discussed in detail.

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13

Joseph, Suman C. "Allelic variations in the chicken insulin-like growth factor-I gene : effects on traits of economic importance in poultry." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35902.

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Due to the importance of insulin-like growth factor-I (IGF-I) in regulating many physiological and metabolic processes, the IGF-I gene was chosen as a candidate gene to study trait associated polymorphisms in chickens. A PstI restriction fragment length polymorphism (RFLP) was detected at the 5' region of the gene and mapped to about 7 Kb upstream of the published promoter sequence. Analysis for association of the marker with traits of economic importance in an unselected, random-bred population of 359 White Leghorns revealed a significant association with egg weight (P ≤ 0.05) and specific gravity (P ≤ 0.05). There was also a trend for association with juvenile body weight (P = 0.08) but not adult body weight. For egg weight the PstI (-/-) genotype was associated with lower egg weight as compared to the heterozygote or the PstI (+/+) genotype. The PstI marker also was found to be significantly associated with differences in trait correlations. A regulatory loop that co-ordinated feed consumption, body weight, egg weight and rate of egg laying was detected, and this regulatory loop differed among the IGF-I genotypic classes. In the PstI (+/-) genotype, the degree of correlation between some of the traits was time dependent, while in the PstI (+/+) genotype it remained constant through the different periods of measurement. Since IGF-I is known to play an important role in immune functions, the association of the IGF-I genotypes with immune traits was also investigated. A significant association was found for delayed type hypersensitivity, interferon production and T-cell count (P ≤ 0.05). Individuals belonging to the PstI (+/-) genotypic class exhibited higher immune response, reflected by the delayed type hypersensitivity reaction and antibody the interactive effects of marker genotypes in the GH, GH-receptor and IGF-I genes on traits and trait correlations indicated that the three are part of an epistatic pathway, wherein the phenotypic consequences of

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14

Brice, Amy L. "Growth factors and lipid transport in early mammalian development." Thesis, University of Oxford, 1990. http://ora.ox.ac.uk/objects/uuid:63dddafd-edd7-4c90-8b22-17b9ef81f96f.

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15

Kinhult, Anne. "Barramundi (Lates calcarifer) IGF-I : characterization of cDNA, genomic sequences, and regulation of mRNA expression." Thesis, Queensland University of Technology, 1996.

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16

Ohlsen, Susan M. "Cloning and characterization of ovine insulin, insulin-like growth factor-I and -II genes." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-165729/.

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17

Stahlbom, Axel. "Characterisation of human IGF-I precursor prohormones : distinct function of IGF-IA and IGF-IB prohormones in the regulation of cellular growth." Thesis, Queensland University of Technology, 1996.

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18

Bode-Rhoads, Michelle Lynn. "Regulation of the growth hormone receptor, insulin-like growth factor (IGF) I and IGF binding protein 2 in reproductive tissues of dairy cattle during lactation and associated effects on fertility." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3164490.

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19

Gargosky, Sharron Erna. "Insulin-like growth factor (IGF) and IGF binding proteins during pregnancy in the rat and human /." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phg2315.pdf.

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20

沈維華 and Weihua Shen. "Stability and absorption of milk-borne growth factors in the gastrointestinal tract of neonatal pigs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237642.

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21

Ryder, Jeffrey W. "The effects of fasting and refeeding on insulin-like growth factor-I stimulated glucose transport." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020146.

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Insulin-like growth factor-I (IGF-I) is a known stimulator of glucose transport. IGF binding protein 1 (IGFBP1) is a protein that regulates the actions of IGF-I by binding to IGF-I which alters it's ability to bind to the IGF-I receptor. Diet and exercise may influence this system. While IGFBP1 levels increase with fasting or prolonged exercise, feeding will reverse this elevation. The intent of this study was to determine if an in vivo manipulation of IGFBP1 affects in vitro glucose transport in the rat soleus. Sixteen male Spaque Dawley rats were fasted for 12 hours. Half of the animals were then allowed a two hour ad libitum refeeding period. Animals were anesthetized and had their soleus muscles removed. Muscles were then randomly assigned to one of four treatment groups. Treatments involved an incubation in either 4 or 8 mM glucose in either the presence or absence of IGF-I (75 ng x ml"'). Final incubation for all treatment groups included [3H]-3-O-methylglucose (437 µCi x mM-) for the measurement of glucose transport. Following incubation, muscles were weighed, homogenized in 1 ml of 10% trichloroacetic acid, and centrifuged to precipitate out protein. 100 µl of the supernatant was added to 3 ml of scintillation fluid and analyzed in a scintillation counter. Glucose transport was determined by 3H activity. A statistical analysis of the various groups shows that there is no significant difference between fasted and refed animal for any specific treatment. However, when all the fasted and refed animals area grouped, glucose transport rate is significantly greater (p<0.05) in fasted (3.59 ± 0.44 µM x ml"' x hr) animals than in refed animals (2.56 ± 0.27 µM x ml"' x hr'). Additionally, muscles that were treated with IGF-I in 8 mM glucose demonstrated a greater rate of glucose transport (5.12 ± 0.68 µM x ml-1 x hr') than all other treatments (2.13 ± 0.39 to 2.90 ± .33 µM x ml-' x hr'). This study showed that IGF-I is a stimulator of glucose transport in an 8 mM glucose media. Additionally, the results show that glucose transport is greater if the animals are fasted. The differences between fasted and refed animals demonstrated in this study supports the hypothesis that diet manipulated IGFBP1 levels are able to alter the biological effects of IGF-I.
School of Physical Education

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22

Kocamis, Hakan. "Functional profiles of growth related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2026.

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Thesis (Ph. D.)--West Virginia University, 2001.
Title from document title page. Document formatted into pages; contains ix, 109 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 88-104).

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23

Shen, Weihua. "Stability and absorption of milk-borne growth factors in the gastrointestinal tract of neonatal pigs /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19867943.

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24

Fild, Deborah S. "The effects of oral arginine supplementation on growth hormone, arginine, and somatomedin levels during energy restriction in male weight lifters." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11242009-020056/.

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25

Ronge, Harald Dieter. "Investigations on somatomedin C and somatotropin in cattle : changes during pregnancy, parturition, lactation and growth, modified by energy and protein intake /." [S.l.] : [s.n.], 1989. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8772.

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26

Ankrapp, David P. "The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/39726.

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The concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, A427, SK-LU-1) expressed the type I IGF-I receptor protein and IGF-I stimulated the proliferation of low density plated (2000 cells/cm² growth area) carcinoma cells by 1.6- to 3- fold above control after a four day inCUbation period under serum-free conditions (A549, A427) or in the presence of 0.25% serum (SK-LU-1). In addition, when added to detergent-solubilized type I IGF receptors from A549 cells, IGF-I stimulated [1] a dose-dependent increase in the autophosphorylation of the type I IGF receptor, and [2] a dose-dependent increase (1.5- to 4-fold) in the phosphorylation of a tyrosine kinase-specific substrate. These results suggest that the growth promoting activity of IGF-I for the lung carcinoma cells was mediated through the activation of the type I IGF receptor.
Ph. D.

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27

Gao, Shan. "Screen for proteins that regulate sensitivity to inhibition of the insulin-like growth factor 1 receptor." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565965.

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The type 1 insulin-like growth factor receptor (lGF-1 R) plays a significant role in tumor growth and spread, and IGF-1 R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1 R inhibition remain unclear. The aim of this project is to identify proteins whose depletion regulates sensitivity to IGF-1 R inhibition, in order to design effective combination treatments to benefit patients. An IGF-1 R kinase inhibitor, AZ12253801 (provided by AstraZeneca) was able to block IGF-induced phosphorylation of IGF-1 R in DU145 prostate cancer and MCF-7 breast cancer cells, inhibited downstream signalling in DU145 cells, and also inhibited proliferation and cell survival of both cell lines. AZ12253801 was used in an unbiased siRNA screen in both cell lines, using two s'iRNA libraries (779 kinase-related Kinome and 230 DNA repair-associated siRNAs). Eight Kinome and five DNA repair-associated hits have been identified after primary and second round screens, and further validated. The strongest hit was dishevelled homolog 3 (DVL3), a member of the WNT signalling pathway, which is highly expressed in both cell lines. DVL3 silencing caused reduction in active l3-catenin and inactivated the mTOR pathway, consistent with previous studies, and did not affect IGF-1 Rand AKT activity. However, DVL3 silencing led to activation of MEK1/2-ERK1/2 in serum-starved cells and sensitized this pathway to IGF-1 stimulation, with translocation of ERK1/2 into the nucleus and increased expression of ERK1/2 target genes. A DVL PDZ domain inhibitor (DVLi) showed similar effects on active l3-catenin, mTOR signalling and ERK1/2 signalling activity. The administration of DVLi increased sensitivity to AZ12253801 in cell lines with detectable ERK1/2 activation, but not prostate cancer cells in which ERK signalling was suppressed and AKT was activated in the context of loss of functional PTEN. Furthermore, DVL3 regulated activation of ERKs by influencing signaling downstream of the IGF-1 R and upstream of RAS, and DVL3 was found in a complex with the adaptor proteins GRB2 and DAB2. GRB2 knockdown was capable of abolishing ERK1/2 activation induced by DVLi, further implicating involvement of GRB2, and DAB2 silencing sensitized to IGF-1 R inhibition, mimicking effects of DVL3 depletion. Taken together, DVL3 silencing or inhibition enhances sensitivity to IGF-1 R inhibition by negatively regulating the ERK1/2 signaling pathway. These investigations shed new light on the factors that regulate IGF signaling, and provide a rational basis for design of clinical trials of IGF-1 R inhibitors.

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28

Chui, Shiu Hon. "Biochemical and pharmacological effects of Chinese medicines on homocysteine and insulin-like growth factor-1 in health and in disease." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/539.

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29

Woll, Steven Cody. "Insulin-like Growth Factor Pathway Described in Austrofundulus limnaeus Diapause and Escape Embryos." PDXScholar, 2016. https://pdxscholar.library.pdx.edu/open_access_etds/3207.

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Development in the annual killifish Austrofundulus limnaeus can follow two distinct developmental trajectories. Typical development includes the entrance of embryos into a state of metabolic and developmental arrest termed diapause. Alternately, embryos can escape diapause and develop directly without pause. These two trajectories are characterized by differences in the rate and timing of developmental, morphological, and physiological traits. Insulin and Insulin-like growth factor (IGF) signaling (IIS) is known to regulate entrance into diapause in a variety of invertebrates. In this thesis I explore the possible role of IGFs in the regulation of development and diapause in embryos of A. limnaeus. Here I report stage-specific expression of IGF-I and II proteins and their associated mRNA transcripts. Patterns of IGF-I protein expression are consistent with IGF signaling playing a major role in supporting the escape trajectory. In addition, treatment of embryos with a potent inhibitor of the IGF-I receptor (IGF1R) mimics the diapause developmental pattern even under conditions that should favor direct development. Evaluation of mRNA gene expression patterns in the two developmental trajectories suggests a role for IGF-I signaling through the RAS-MAPK-ERK pathway, which may be promoting the escape phenotype. Additionally, IGF-I activity may be enhanced in escape trajectory embryos though upregulation of IGF binding protein 2 (IGFBP-2) mRNA. These data suggest a major role for IGF signaling in the promotion of the escape trajectory, and thus we predict that specific mechanisms are in place in diapause-bound embryos that block IGF signaling and thus promote entrance into diapause. The data presented here suggest that blocking IGF signaling is critical for induction of diapause, but also suggests that other signaling pathways are likely also at play. Other pathways such at the TGF-beta signaling molecules and SMAD pathway, may also be involved in the direct regulation of the diapause phenotype, as has been shown for other animal models of developmental arrest.

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30

Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Title page, table of contents and synopsis only, 1998. http://web4.library.adelaide.edu.au/theses/09MD/09mdm3685.pdf.

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Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound site if binding protein affinity is decreased. Discusses possible roles of these binding proteins in wound repair.

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31

Obese, Frederick Yeboah. "Concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in the plasma and milk of pasture-fed dairy cows in early lactation /." Connect to thesis, 2003. http://eprints.unimelb.edu.au/archive/00000549.

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32

Foster, Ernest Byron Pascoe David D. "Acute regulation of IGF-1 by differential growth-factor-binding-protein expression, inhibition, and proteolysis." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Health_and_Human_Performance/Dissertation/Foster_Ernest_45.pdf.

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33

Durrer, Katherine Elaine. "Impact of a Genetically Engineered Probiotic Therapy and IGF-1 Genomics in the PAHenu2 Mouse Model of PKU." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822730/.

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Absence of functional phenylalanine hydroxylase results in phenylketonuria (PKU). Viable treatments remain few, expensive and secondary conditions such as osteopenia occur in most PKU patients. Objective 1: Given the recently described roles of gut microbes to aid host digestion, an orally administered genetically engineered probiotic as the delivery vehicle for enzyme replacement therapy was created. The engineered probiotic, pHENOMMenal, produced phenylalanine ammonia lyase with significant production of trans-cinnamate (phenylalanine cleavage product) in vitro and resulted in a reduction of 515 μM in blood phenylalanine when fed to PKU animals for 14 days (from 2307µM ± 264µM to 1792µM ± 261µM, n = 6, P < 0.05). The control probiotic produced no change in blood phenylalanine. Thus, pHENOMMenal treatment in PKU mice demonstrated engineered microbes could compensate for a metabolic deficiency of the host. Objective 2: Evaluate the PAHenu2 mouse model of PKU for a genetic discrepancy causing ocular enlargement and delayed development observed only after the PAHenu2 mutation was crossed to the C57BL/6J mouse. When compared to healthy littermates, ELISA indicated a consistent but insignificant decrease in plasma IGF-1 and an increase in ocular IGF-1 in PKU animals. SNP screening demonstrated a differential inheritance of IGF-1 alleles in healthy and PKU animals based on PAH allele inheritance. Ocular and developmental phenotypes in the PAHenu2 colony match those described in previous IGF-1 studies. Understanding the IGF-1 inheritance discrepancy will enable better osteopenia research using PAHenu2 mice and allow breeding of a healthier mouse colony for continued research. Collectively the results from this work describe a new therapeutic approach for treatment of PKU as well as a better understanding of the PAHenu2 mouse model to study this disease.

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34

Hack, Nicole L. "The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1824.

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Growth performance in vertebrates is regulated by environmental factors including the quality and quantity of food, which influences growth via endocrine pathways such as the growth hormone (GH) / insulin-like growth factor somatotropic axis. In several teleost fishes, circulating concentrations of insulin-like growth factor-1 (Igf1) correlate positively with growth rate, and it has been proposed that plasma Igf1 levels may serve as an indicator of growth variation for fisheries and aquaculture applications. Here, I tested whether plasma Igf1 concentrations might serve as an indicator of somatic growth in olive rockfish (Sebastes serranoides), one species among dozens of rockfishes important to commercial and recreational fisheries in the Northern Pacific Ocean. I reared juvenile olive rockfish under food ration treatments of 1% or 4% wet mass per d for 98 d to experimentally generate variation in growth. Juvenile rockfish in the 4% ration grew 60% more quickly in mass and 22% faster in length than fish in 1% ration. Plasma Igf1 levels were elevated in rockfish under the 4% ration, and individual Igf1 levels correlated positively with growth rate, as well as with individual variation in hepatic igf1 mRNA levels. These data in olive rockfish support the possible use of plasma Igf1 as a positive indicator of growth rate variation in rockfishes. Using my findings from this experiment, I further investigated the use of this biomarker in wild rockfish by examining patterns of Igf1 variation in blue rockfish (Sebastes mystinus) caught within and outside of two Marine Protected Areas (MPAs) along California’s coast: Piedras Blancas MPA and Point Buchon MPA. Individual Igf1 levels correlated positively with increasing size as seen in laboratory reared fish. After correcting plasma Igf1 values for body size, circulating Igf1 was observed to be higher in blue rockfish within the boundaries of the Piedras Blancas MPA compared to fish from an adjacent site with no fishing restrictions. Igf1 levels in blue rockfish caught within the Point Buchon MPA, however, were similar to those outside of that MPA. These results suggest that blue rockfish within the Piedras Blancas MPA may experience enhanced growth relative to conspecifics outside of that MPA’s boundaries, and that such growth increases may be specific to MPA locations. My findings support previous studies that Igf1 is a positive indicator for growth in teleost fish and can be used as a tractable biomarker in wild rockfish which could enhance management efforts of fish stocks within marine protected areas.

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35

Kobayashi, Yasuhiro. "Changes in the activity of growth hormone receptor promotor 1 in liver of cattle /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974648.

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36

Kind, Karen Lee. "Insulin-like growth factors and growth of the fetal sheep /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk525.pdf.

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37

Cheung, Catherine Wing Ying. "IGF family members in renal cell carcinoma : their roles in malignancies and therapeutic interventions /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18766.pdf.

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38

Farhat, Antoine G. "Growth and IGF-I response to breast muscle selection by ultrasound and dietary protein programs in Pekin ducks." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ55327.pdf.

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39

Long, Ezhou. "Involvement of insulin-like growth factor I and its binding proteins on proliferation and differentiation of murine bone marrow macrophage precursors." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27371.

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The alteration of insulin-like growth factor I (IGF-I) and its binding proteins (IGFBP) and their effects on proliferation and differentiation of murine bone marrow-derived macrophage (BMM) precursors were investigated. Bone marrow cells exposed to 20% L929-fibroblast conditioned medium (LCM) were cultured in serum-free medium for 24 h. Western ligand blotting (WLB) analysis detected four bands in all samples. 41-kDa and 30-kDa bands were detected after 12 h and remained constant during BMM differentiation. The 28-kDa and 25-kDa proteins were almost undetectable until day 2, but accumulated significantly from day 3 to day 7. Immunoblotting analysis verified these two bands as IGFBP-4. Northern blotting analyses detected both IGFBP-4 and IGFBP-3 mRNA in the cells. The 41-kDa protein was postulated to be IGFBP-3 in a glycosylated form. The identity of the 30-kDa band is not known. Northern blotting analysis showed that IGF-I mRNA level increased in a time-dependent manner until day 3, and decreased thereafter during BMM differentiation. The effect of IGF-I and its analogs on cell proliferation was studied by ($ sp3$H) thymidine incorporation. IGF-I and its analogs enhanced cell proliferation of freshly isolated bone marrow cells. Both IGF-I and long R$ sp3$ IGF-I, but not des(1-3)IGF-I, continued to exert a stimulating effect on day 1, although to a lesser extent. The effect of IGF-I and its analogs on BMM differentiation was studied by checking morphology, non-specific esterase-1 (NSE-1) activity, and mannose receptor expression. No significant differences in morphology and NSE-1 activity were observed among the treatment groups. There was no difference of mannose receptor expression on day 4 between the IGF-I group and the control cells, whereas long R${ sp3}$ and des(1-3)IGF-I increased the receptor number by 260% and 228% respectively, with less increased K$ rm sb{d}$ values. (Abstract shortened by UMI.)

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40

Yuen, John Shyi P. "The role of the type 1 insulin-like growth factor receptor (IGF1R) in renal cancer." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670113.

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41

Bischler, Troy K., and University of Lethbridge Faculty of Arts and Science. "The utility of resting levels of IGF-I and IGFBP-3 as markers of training status in elite athletes." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, c2007, 2007. http://hdl.handle.net/10133/651.

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Insulin-like growth factor-I (IGF-I) and its principle binding protein (IGFBP-3) are believed to play a role in mediating the anabolic effects of exercise. The purpose of this study was to assess the effect of 4 months of training on IGF-I and IGFBP-3, and to determine if changes in IGF-I or IGFBP-3 were related to changes in training status. Twelve varsity swimmers (5 males, 7 females) were tested pre-season, and again after 8 and 16 weeks of training. Measures included: VO2 max, nutritional status, athletic performance, subjective symptoms of overtraining, and serum levels of IGF-I and IGFBP-3. There was no significant change across time in VO2 max, athletic performance, IGF-I or IGFBP-3. Resting IGFBP-3 was positively correlated to symptoms of overtraining at week 0 (p=0.017), however, this relationship did not persist at week 8 or 16. These findings can not confirm that resting levels of IGF-I and IGFBP-3 are sensitive markers of training status.
ix, 105 leaves : ill. ; 29 cm.

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42

Takiguchi, Megumi. "The function of the type 1 insulin-like growth factor receptor (IGF1R) in intestinal tumorigenesis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670044.

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43

Dobbins, Adam Bradley. "Potential mechanisms linking nutrition and neuroendocrine control of reproduction in the sheep." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3615.

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Thesis (M.S.)--West Virginia University, 2004.
Title from document title page. Document formatted into pages; contains iv, 124 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 82-124).

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44

Maquart, François-Xavier. "Regulation de la synthese de collagene et de la proliferation des fibroblastes par des effecteurs extracellulaires." Reims, 1987. http://www.theses.fr/1987REIMS013.

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Les effets de 4 types d'effecteurs (glucose, somatomedine a, glycoproteines de structure extraites du tissu conjonctif normal et de triterpenes extraits de centella asiatica) sur la synthese du collagene ou la proliferation cellulaire ont ete etudies dans des cultures de fibroblastes dermiques. Le glucose inhibe la proliferation fibroblastique. La somatomedine a induit une orientation preferentielle des mecanismes de synthese proteique vers la production de proteine intracellulaires avec une retention de procollogene. Un effet inhibiteur de certaines molecules sur la synthese de proteines totales. L'etude des triterpenes a permis de mettre en evidence l'effet stimulant de l'acide lique, sur la synthese au collagene

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45

Van, Renen Margaret Jean. "Effects of GH on the IGF's and IGFBP's in children with chronic renal failure and transplantation /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09MD/09mdv274.pdf.

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46

FROMMER, PATRICIA. "La somatomedine-c comme mediateur biologique et marqueur nutritionnel." Strasbourg 1, 1991. http://www.theses.fr/1991STR15016.

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47

Doyle, Kharen Leigh. "The control of insulin-like growth factor-1 (IGF-1) in the spinal cord of the rat." Thesis, Queensland University of Technology, 1999.

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48

NEGRE, FLORENCE. "Retinopathie diabetique proliferative et somatomedine c : etude clinique et immunohistochimique." Nice, 1990. http://www.theses.fr/1990NICE6806.

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49

Degger, Brian. "Fish insulin-like growth factors : their role in growth from a functional perspective." Thesis, Queensland University of Technology, 2001.

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50

VERCOUTERE, FREMAUX LUCILE. "Place du dosage de la somatomedine c dans l'insuffisance staturale chez l'enfant." Reims, 1990. http://www.theses.fr/1990REIMM072.

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