Добірка наукової літератури з теми "SmORF peptide"
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Статті в журналах з теми "SmORF peptide"
Markus, Damien, Aurore Pelletier, Muriel Boube, Fillip Port, Michael Boutros, François Payre, Benedikt Obermayer, and Jennifer Zanet. "The pleiotropic functions of Pri smORF peptides synchronize leg development regulators." PLOS Genetics 19, no. 10 (October 30, 2023): e1011004. http://dx.doi.org/10.1371/journal.pgen.1011004.
Повний текст джерелаLyapina, Irina, Vadim Ivanov, and Igor Fesenko. "Peptidome: Chaos or Inevitability." International Journal of Molecular Sciences 22, no. 23 (December 4, 2021): 13128. http://dx.doi.org/10.3390/ijms222313128.
Повний текст джерелаDouka, Katerina, Isabel Birds, Dapeng Wang, Andreas Kosteletos, Sophie Clayton, Abigail Byford, Elton J. R. Vasconcelos, et al. "Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation." RNA 27, no. 9 (June 30, 2021): 1082–101. http://dx.doi.org/10.1261/rna.078782.121.
Повний текст джерелаBonilauri, Bernardo, Fabiola Barbieri Holetz, and Bruno Dallagiovanna. "Long Non-Coding RNAs Associated with Ribosomes in Human Adipose-Derived Stem Cells: From RNAs to Microproteins." Biomolecules 11, no. 11 (November 11, 2021): 1673. http://dx.doi.org/10.3390/biom11111673.
Повний текст джерелаDozier, Christine, Audrey Montigny, Mireia Viladrich, Raphael Culerrier, Jean-Philippe Combier, Arnaud Besson, and Serge Plaza. "Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila." International Journal of Molecular Sciences 23, no. 10 (May 20, 2022): 5764. http://dx.doi.org/10.3390/ijms23105764.
Повний текст джерелаSouthan, Christopher. "Last rolls of the yoyo: Assessing the human canonical protein count." F1000Research 6 (April 7, 2017): 448. http://dx.doi.org/10.12688/f1000research.11119.1.
Повний текст джерелаWan, Linrong, Wenfu Xiao, Ziyan Huang, Anlian Zhou, Yaming Jiang, Bangxing Zou, Binbin Liu, Cao Deng, and Youhong Zhang. "Systematic identification of smORFs in domestic silkworm (Bombyx mori)." PeerJ 11 (January 13, 2023): e14682. http://dx.doi.org/10.7717/peerj.14682.
Повний текст джерелаCao, Yipeng, Rui Yang, Imshik Lee, Wenwen Zhang, Jiana Sun, Xiangfei Meng, and Wei Wang. "Prediction of LncRNA-encoded small peptides in glioma and oligomer channel functional analysis using in silico approaches." PLOS ONE 16, no. 3 (March 18, 2021): e0248634. http://dx.doi.org/10.1371/journal.pone.0248634.
Повний текст джерелаMagny, Emile G., Jose Ignacio Pueyo, Frances M. G. Pearl, Miguel Angel Cespedes, Jeremy E. Niven, Sarah A. Bishop, and Juan Pablo Couso. "Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames." Science 341, no. 6150 (August 22, 2013): 1116–20. http://dx.doi.org/10.1126/science.1238802.
Повний текст джерелаDragomir, Mihnea P., Ganiraju C. Manyam, Leonie Florence Ott, Léa Berland, Erik Knutsen, Cristina Ivan, Leonard Lipovich, Bradley M. Broom, and George A. Calin. "FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs." Non-Coding RNA 6, no. 4 (September 23, 2020): 41. http://dx.doi.org/10.3390/ncrna6040041.
Повний текст джерелаДисертації з теми "SmORF peptide"
Pelletier, Aurore. "Fonctions des peptides smORF Tic-Tac et Sem1 dans la reproduction et le développement chez la Drosophile." Electronic Thesis or Diss., Toulouse 3, 2023. http://www.theses.fr/2023TOU30269.
Повний текст джерелаRecent technological advances have revealed that small ORFs (Open Reading Frame), which are less than 100 codons in size and were previously considered non-coding due to their small size, can be translated into thousands of smORF (small ORF) peptides in all organisms. Several studies have shown that smORF peptides can interact with canonical proteins and regulate their activity. Thus, the smORF peptide family represents a vast unexplored reservoir of potential regulators. A functional screen carried out in Drosophila identified new smORF peptides involved in development, several of which are derived from polycistronic RNA translation. My thesis research project was to characterize the function in Drosophila of 1) Tic and Tac, two unknown smORF peptides encoded by a bicistronic RNA, and 2) Sem1/DSS1, a highly conserved peptide. The first part of my thesis was to analyze the biological function of two unknown smORF peptides encoded by a bicistronic RNA that we named tictac. I demonstrated that Tic and Tac are two peptides translated from the same bicistronic RNA tictac, but with different AA sequences and cellular localization. In vivo, tictac is highly expressed in male reproductive organs. Following mating, behavioral and physiological changes characterizing the post-mating response in female, which are mainly induced by the seminal fluid, are affected in the absence of tictac in males. Using transcriptome analysis on male reproductive organs, I show that the absence of tictac leads to transcriptional deregulation of 150 genes. Among them, 10% code for seminal fluid components, proving that tictac regulates its composition. Specific deletion of either tic or tac highlights that they have different in vivo functions, but that both are involved in seminal fluid synthesis. The analysis of accessory glands, the functional seminal fluid-producing organ equivalent to the human prostate, reveals that their maturation and secretory function are regulated by tictac. The search for homologs of Tic and Tac indicates that Tic has a peptide domain with strong homology to a subdomain of RQC1, a yeast protein involved in ribosome quality control, and Tac has a serglycin domain, known in human to have important functions in secretion. My data therefore suggests that Tic and Tac smORF peptides may contribute to the synthesis and secretion of seminal fluid proteins. In a second step, I carried out the molecular analysis of Sem1, an intrinsically disordered protein known to interact with and regulate several macromolecular complexes. As these data were only generated in cellulo and in vitro models, I carried out the molecular analysis of Sem1 for the first time in vivo. I showed that Sem1 is essential, as its deletion induces lethality at the larval stage. Moreover, its absence leads to massive apoptosis that generalizes to the whole tissue in a non-cell-autonomous manner. To uncouple the molecular functions of Sem1 and identify the protein domains essential for cell survival, I generated a mutated form of each functional domain, then induced its expression in the absence of endogenous Sem1. This structure-function analysis revealed that two domains known to interact with ubiquitin are essential for development. In conclusion, my thesis work highlights new functions of smORF peptides in reproduction and cell survival, illustrating the ability of smORF peptides to act on multiple macro-molecular complexes, thus controlling numerous physiological processes