Добірка наукової літератури з теми "Smoothened signaling pathway"
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Статті в журналах з теми "Smoothened signaling pathway"
Kim, June Myoung, Hyeseung Han, Minjin Bahn, Yeokyu Hur, Chang-Yeol Yeo, and Dae-Won Kim. "Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened." Biochemical Journal 477, no. 1 (January 8, 2020): 121–36. http://dx.doi.org/10.1042/bcj20190784.
Повний текст джерелаFaria, Alessandra V. de S., Adamu Ishaku Akyala, Kaushal Parikh, Lois W. Brüggemann, C. Arnold Spek, Wanlu Cao, Marco J. Bruno, Maarten F. Bijlsma, Gwenny M. Fuhler, and Maikel P. Peppelenbosch. "Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling." Journal of Biological Chemistry 294, no. 25 (April 16, 2019): 9787–98. http://dx.doi.org/10.1074/jbc.ra119.007956.
Повний текст джерелаJeng, Kuo-Shyang, I.-Shyan Sheen, Chuen-Miin Leu, Ping-Hui Tseng, and Chiung-Fang Chang. "The Role of Smoothened in Cancer." International Journal of Molecular Sciences 21, no. 18 (September 18, 2020): 6863. http://dx.doi.org/10.3390/ijms21186863.
Повний текст джерелаKhaliullina, Helena, Mesut Bilgin, Julio L. Sampaio, Andrej Shevchenko, and Suzanne Eaton. "Endocannabinoids are conserved inhibitors of the Hedgehog pathway." Proceedings of the National Academy of Sciences 112, no. 11 (March 2, 2015): 3415–20. http://dx.doi.org/10.1073/pnas.1416463112.
Повний текст джерелаMeloni, Alison R., Gregory B. Fralish, Patrick Kelly, Ali Salahpour, James K. Chen, Robert J. Wechsler-Reya, Robert J. Lefkowitz, and Marc G. Caron. "Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2." Molecular and Cellular Biology 26, no. 20 (August 14, 2006): 7550–60. http://dx.doi.org/10.1128/mcb.00546-06.
Повний текст джерелаFan, Junwan, Zichen Zhao, Ru Liu, Haowen Li, Wenyan He, Jianping Wu, Yongjun Wang, and Wei Chen. "A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy." International Journal of Molecular Sciences 23, no. 23 (November 22, 2022): 14505. http://dx.doi.org/10.3390/ijms232314505.
Повний текст джерелаGonnissen, Annelies, Sofie Isebaert, and Karin Haustermans. "Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened." Oncotarget 6, no. 16 (May 22, 2015): 13899–913. http://dx.doi.org/10.18632/oncotarget.4224.
Повний текст джерелаPietrobono, Silvia, and Barbara Stecca. "Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors." Cells 7, no. 12 (December 14, 2018): 272. http://dx.doi.org/10.3390/cells7120272.
Повний текст джерелаMartorana, Margherita. "A formalization of one of the main claims of “Sonic hedgehog signaling in astrocytes” by Hill et al. 20211." Data Science 5, no. 1 (March 22, 2022): 35–37. http://dx.doi.org/10.3233/ds-210043.
Повний текст джерелаShyamala, Baragur V., and Krishna Moorthi Bhat. "A positive role for Patched-Smoothened signaling in promoting cell proliferation during normal head development in Drosophila." Development 129, no. 8 (April 15, 2002): 1839–47. http://dx.doi.org/10.1242/dev.129.8.1839.
Повний текст джерелаДисертації з теми "Smoothened signaling pathway"
Nedelcu, Daniel. "Smoothened regulation in the Hedgehog signaling pathway." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11080.
Повний текст джерелаBruzzone, Lucía. "A crosstalk between the RNA binding protein Smaug and the Hedgehog pathway links cell signaling to mRNA regulation in drosophila." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/BRUZZONE_Lucia_1_va_20180319.pdf.
Повний текст джерелаPost-transcriptional regulation of gene expression plays a critical role in a variety of cellular processes during development. RNA binding proteins are fundamental mediators of post-transcriptional regulations that control mRNA expression by recognizing specific cis acting elements within the target transcripts. Smaug is a highly conserved sequence specific RNA-binding protein that is essential during Drosophila early embryogenesis. Smaug binds Smaug Recognition Elements (SRE) in the target mRNA and recruits additional factors, via protein-protein interactions, that regulate the bound mRNA. An emergent concept that signaling pathways can modulate RBP activity by post-translation modifications adds a new layer in the control of gene expression. During my thesis work, I sought to understand how the Hedgehog pathway regulates Smaug by promoting its phosphorylation. My work shows that HH signaling downregulates Smaug protein levels affecting its ability to repress mRNA translation. This negative effect seems to be dependent on the interaction between Smaug and the HH signal transducer Smoothened. Moreover, Smaug is constitutively phosphorylated in its RNA binding domain, which appears to be necessary for cytoplasmic Smaug foci formation
Byrne, Eamon. "Molecular mechanisms of Hedgehog signal transduction by the G-protein coupled receptor smoothened." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:38abef20-ae98-4835-919c-73afc21a6252.
Повний текст джерелаWhalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.
Повний текст джерелаTong, Chao. "Studies of Smoothened in Hedgehog Signaling Pathway." 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=232.
Повний текст джерелаLinder, Benedikt. "Interaction of the Hedgehog and vitamin D receptor signaling pathways in Patched associated cancers." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5FDC-A.
Повний текст джерелаТези доповідей конференцій з теми "Smoothened signaling pathway"
Karlou, Maria, Vassiliki Tzelepi, Sankar Maity, Nora M. Navone, Jun Yang, Jing‐Fang Lu, Anh Hoang, Christopher J. Logothetis, and Eleni Efstathiou. "Abstract C253: Effective inhibition of Hedgehog signaling pathway with small molecule Smoothened inhibitor GDC‐0449 in a bone producing prostate cancer xenograft." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c253.
Повний текст джерелаNasution, M. A. F., F. Stephanie, and U. S. F. Tambunan. "Pharmacophore-based virtual screening and molecular docking simulation of flavonoids as smoothened protein inhibitor of Hedgehog signaling pathways." In PROCEEDINGS OF THE 4TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES (ISCPMS2018). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5132487.
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