Статті в журналах: "SKAM1"

1

Kann-Rasmussen, Nanna, and Gitte Balling. "Endelig! Historien om en tiltrængt public service succes." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 82–88. http://dx.doi.org/10.7146/ntik.v6i2.99081.

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The article discusses why and how SKAM, as a public service production, has become a success. The article presents two interconnected challenges for public service broadcasters today. The first challenge pertains to the fact that young people in particular turn away from traditional television; the second challenge relates to the concept social media logic, a logic that is largely incompatible with public service logic. The article presents a discussion on how SKAM has met these challenges. The article focusses mainly on its Danish reception. Through SKAMs thematic emphasis, the series offers its intended audience (young people) a contemporary guide to Nordic values. Furthermore, its transmedial distribution has engaged a large audience of people who are otherwise moving away from traditional public service content.

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2

Jerslev, Anne. "SKAMs ’lige her’ og ’lige nu’ : Om SKAM og nærvær." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 75–81. http://dx.doi.org/10.7146/ntik.v6i2.99080.

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The article discusses strategies for creating presence in space and time in SKAM, in particular the way the series unfolds as event and its extended use of close-ups. Moreover, the article discusses Bolter and Grusin’s understanding of immediacy and argues that the many mobile screens as well as the series’ cross-mediality, or hypermediacy, contribute to the creation of an impression of being close to the characters and their world, in time and space.

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3

Musch, Mark W., Amanda B. Puffer, and Leon Goldstein. "Volume expansion stimulates monoubiquitination and endocytosis of surface-expressed skate anion-exchanger isoform." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 5 (May 2008): R1657—R1665. http://dx.doi.org/10.1152/ajpregu.00837.2007.

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In hyposmotic medium, skate erythrocytes swell and then lose taurine and other solutes with obligate water to achieve a regulatory volume decrease (RVD) over a 90-min period. The skate erythrocyte anion-exchanger isoform 1 (skAE1) participates in the RVD, and increased surface expression after hyposmolality-induced volume expansion occurs within 5 min but decreases to baseline within 120 min. The subsequent fate of skAE1 is the focus of these studies. SkAE1 sent to the surface becomes monoubiquitinated, a modification that is present while skAE1 is associated with clathrin and Rab5 but is removed before skAE1 is passed to the Rab4 compartment. Endocytosis of skAE1 involves clathrin-mediated internalization. Surface plasma membrane skAE1 forms tetramers and demonstrates increased tyrosine phosphorylation, and both of these processes decrease before skAE1 appears in the Rab5 compartment. Volume expansion-stimulated surface skAE1 comes from an intracellular pool in a buoyant membrane fraction resistant to nonionic detergent extraction (DRM), and the amount of skAE1 increases in this buoyant DRM fraction on the surface. Clathrin heavy chain is found largely in the erythrocyte DRM, but in dense, rather than buoyant, fractions. Rab5- and Rab4-containing membranes are largely detergent soluble, suggesting that as skAE1 is passed to clathrin and then to Rab5 compartments, the membrane microdomain composition changes. The present studies demonstrate that skAE1, which appears on the surface after hyposmolality-induced volume expansion, is monoubiquitinated, a modification that may serve as a signal for removal of skAE1 from the surface. This modification is eliminated after clathrin-mediated removal of skAE1 in a membrane domain containing Rab5, potentially permitting recycling and reuse of skAE1.

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4

Sucularli, Ceren. "Computational assessment of SKA1 as a potential cancer biomarker." Turkish Journal of Biochemistry 44, no. 6 (December 18, 2019): 752–60. http://dx.doi.org/10.1515/tjb-2019-0148.

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Abstract Background Spindle and kinetochore associated complex subunit 1 (SKA1) is an essential component of SKA complex, which is required for the proper formation of kinetochore–microtubule attachment and timely mitotic progression. The aim of this study is to perform detailed analyses of SKA1 genomic and expression alterations in cancers and to assess SKA1 as a biomarker for predicting human cancers and patient prognosis. Materials and methods Missense mutations from human cancers were extracted, deleterious missense mutations were predicted and shown on 3D SKA1 protein. SKA1 expression and the effect of SKA1 expression on patient survival were investigated in human cancers. Results and discussion Most of the predicted deleterious mutations were detected on microtubule-binding domain of SKA1, suggesting mutations on microtubule-binding domain might be more relevant in human cancers. High SKA1 expression was detected in various cancers. In addition, patients with high SKA1 expression showed poor overall survival compared to patients with low SKA1 expression in breast, lung and gastric cancers. Conclusion These results suggest that high SKA1 expression might be a prognostic and predictive biomarker for several cancers and mainly mutations in the microtubule-binding domain of SKA1 might have a deleterious effect for SKA1.

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5

Dong, Chao, Xiao-li Wang, and Bin-lin Ma. "Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma." Disease Markers 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/616541.

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Aim. Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development.Methods. In this study, immunohistochemical analysis was used to determine the expression of SKA1 in papillary thyroid carcinoma (PTC) and adjacent tissues. We used quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis to further verify the results.Results. We found that SKA1 expression was significantly higher in PTC tissues than normal adjacent tissues(P<0.05). There existed a significant correlation among a higher SKA1 expression, including lymphoid node(P=0.005), clinical stage(P=0.015), and extrathyroid invasion(P=0.004). Survival analysis showed high SKA1 expression in PTC patients more likely to relapse after surgery.Conclusion. High SKA1 expression is predictive of poor prognosis of PTC, implying that SKA1 may be a promising new target for targeted therapies for PTC.

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6

Jørgensen, Liv. "En skam." Rus & samfunn 1, no. 03 (August 7, 2007): 3. http://dx.doi.org/10.18261/issn1501-5580-2007-03-01.

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7

Kawakami, Mieko. "Novelle: Skam." Samtiden 125, no. 03 (October 11, 2017): 128–33. http://dx.doi.org/10.18261/issn1890-0690-2017-03-25.

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8

Gjerde, Una Mathiesen. "Blodig skam." K&K - Kultur og Klasse 46, no. 125 (May 15, 2018): 157–78. http://dx.doi.org/10.7146/kok.v46i125.105555.

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Since Aristotle’s time, menstruation has been a stigmatised bodily fluid. It has been a source of shame and guilt for women for centuries. In this article, I focus on how Scandinavian artists since the 1970’s have contributed to make menstruation public through menstrual art. There is wide diversity within Scandinavian menstrual art. Some artists address the menstrual stigma directly in their work, while others use the semiotic and symbolic power of menstrual blood – as abject – to provoke and raise political awareness on feminist issues. I focus on menstrual art in relation to notions of shame and guilt. I argue that menstrual art has contributed to reducing destructive menstrual shame amongst Scandinavian women, even though this may not have been the artists’ main intention in creating the work. Even though the menstrual stigma has been reduced drastically – especially the last five years – menstrual shame has not disappeared. Thus, menstrual art can still contribute to reducing and preventing women from feeling ashamed of their periods. As long as half of humanity menstruates one-third of their life time, the menstrual discussion and menstrual art will remain topics of interest and importance.

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9

Holdhus, Matilde. "Øyeblikkets Skam." DRAMA – Nordisk dramapedagogisk tidsskrift 55, no. 02-03 (December 11, 2018): 34–38. http://dx.doi.org/10.18261/issn2535-4310-2018-02-03-09.

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10

Andersen, Elisabeth Muth, Søren Vigild Poulsen, and Marianne Rathje. "Introduction: Language use in and about the net drama series SKAM." Scandinavian Studies in Language 10, no. 2 (August 27, 2019): 1–5. http://dx.doi.org/10.7146/sss.v10i2.115609.

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On January 30 2018, the University of Southern Denmark in Odense, Denmark, hosted a symposium entitled “Sproget i og omkring SKAM” (“The language in and around SKAM”). After the symposium, we issued a call on behalf of the journal Scandinavian Studies in Language, and two articles were published as a result, namely Jennifer Duggan and Anne Dahl’s article Fan translations of SKAM: Challenging Anglo linguistic and popular cultural hegemony in a transnational fandomand Elisabeth Muth Andersen and Søren Vigild Poulsen’s contribution Viewing, listening and reading along: Linguistic and multimodal constructions of viewer participation in the net series SKAM.

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11

Rustad, Gry Cecilie. "Arven etter Skam." Samtiden 125, no. 03 (October 11, 2017): 104–9. http://dx.doi.org/10.18261/issn1890-0690-2017-03-20.

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12

Grüters, Ruth, and Knut Ove Eliassen. "Medieøkologien i SKAM." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 60–66. http://dx.doi.org/10.7146/ntik.v6i2.99078.

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AbstractTo understand the success of SKAM, the series’ innovative use of “social media” must be taken into consideration. The article follows two lines of argument, one diachronic, the other synchronic. The concept of remediation allows for a historical perspective that places the series in a longer tradition of “real time”-fictions and media practices that span from the epistolary novels of the 18th century by way of radio theatre and television serials to the new media of the 21st century. Framing the series within the current media ecology (marked by the connectivity logic of “social media”), the authors analyze how the choice of the blog as the drama’s media platform has formed the ways the series succeeded in affecting and mobilizing its audience. Given the long tradition of strong pedagogical premises in the teenager serials of publicly financed Norwegian television, the authors note the absence of any explicit media critical perspectives or didacticism. Nevertheless, the claim is that the media-practices of the series, as well as the actions and discourses of its followers (blogposts, facebook-groups, etc.), generate new insights and knowledge with regards to the series’ form, content, and practices.

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13

Rygh, Oda. "Skyld og skam." Tidsskrift for Den norske legeforening 137, no. 7 (2017): 584. http://dx.doi.org/10.4045/tidsskr.17.0214.

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14

Hartz, Emily. "Skam og kedsomhed." Psyke & Logos 43, no. 1 (August 15, 2022): 191–213. http://dx.doi.org/10.7146/pl.v43i1.133893.

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Livets endelighed er et centralt tema i den eksistentielle psykologi.Dette tema behandles ofte med udgangspunkt i døden ogspørgsmålet om, hvordan vi forholder os til vores egen dødelighed.Nærværende artikel undersøger et andet – og påfaldendeoverset – eksistentielt aspekt af livets endelighed, nemlig alderdommen.Artiklen præsenterer et praktisk eksempel på eksistentielgruppeterapi med socialt isolerede ældre plejehjemsbeboereog diskuterer det terapeutiske forløb i lyset af Simone deBeauvoirs eksistentielle analyse af alderdommen.

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15

Christensen, Christa Lykke. "Er web- og tv-serien SKAM en serie om skam?" Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 7–12. http://dx.doi.org/10.7146/ntik.v6i2.98987.

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In this article, I discuss whether the Norwegian teen web series drama SKAM (NRK, 2015-2017) is really about shame and to what extent the fictional characters of the series feel ashamed. The theoretical framework is based on a social psychological conceptualization of shame, supplemented by a micro-sociologically based analysis of the social meaning of face loss and shame. Shame may both entail a negative feeling and an active mechanism serving social and psychological purposes. The main characters of the series are used to analytically exemplify the role of shame and embarrassment. In conclusion, the series does thematize shame and the characters are often placed in conflicts that may give rise to shame. On the other hand, the series also suggests potential social strategies, to constructively avoid the face loss of shameful situations.

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16

Musch, Mark W., and Leon Goldstein. "Tyrosine kinase inhibition affects skate anion exchanger isoform I alterations after volume expansion." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 4 (April 2005): R885—R890. http://dx.doi.org/10.1152/ajpregu.00691.2004.

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Upon exposure to hypotonic medium, skate red blood cells swell and then reduce their volume by releasing organic osmolytes and associated water. The regulatory volume decrease is inhibited by stilbenes and anion exchange inhibitors, suggesting involvement of the red blood cell anion exchanger skAE1. To determine the role of tyrosine phosphorylation, red blood cells were volume expanded with and without prior treatment with the tyrosine kinase inhibitor piceatannol. At the concentration used, 130 μM, piceatannol nearly completely inhibits p72syk, a tyrosine kinase previously shown to phosphorylate skAE1 (M. W. Musch, E. H. Hubert, and L. Goldstein. J Biol Chem 274: 7923–7928, 1999). Hyposmotic-induced volume expansion stimulated association of p72syk with a light membrane fraction of skate red blood cells. Piceatannol did not inhibit this association but decreased hyposmotically stimulated increased skAE1 tyrosine phophorylation. Movement of skAE1 from an intracellular to a surface detergent-resistant membrane domain and tetramer formation were not inhibited by piceatannol treatment. Two effects of hyposmotic-induced volume expansion, decreased band 4.1 binding and increased ankyrin, were both inhibited by piceatannol. These results suggest that at least one event requiring p72syk activation is pivotal for hyposmotic-induced increased transport; however, steps that do not require tyrosine phosphorylation may also play a role.

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17

Ligaard, Eva Elise. "“Hva hører du på?” - Refleksioner over ”SKAM-musikken”." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 54–59. http://dx.doi.org/10.7146/ntik.v6i2.99076.

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In this article I wish to highlight some of the many ways that music functions in SKAM. In particular I wish to ask: Which role does music play in portraying the characters? How are the connotations and associations of specific songs actively used in the TV show? To answer these questions, I will unpack the cultural and historical context of certain songs and musicians and mirror this to selected scenes. I argue that SKAM, through the music selection, actively confronts the audience’s expectations to the characters and both confirms and challenges specific cultural narratives. Hereby cultural codes are turned upside down, and new interpretations are made possible. The soundtrack of SKAM is not used to stress a singular reading of the scenes, but opens up for multiple interpretations. To fans of SKAM, the pre-existing music tracks will be connected to specific scenes, and new connotations of the music appear.

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18

Wang, Ying, Bao-An Chen, Guo-hua Xia, Ziying Jian, Zhi Li, and Yun Lin. "MNPs-Fe3o4 Induce Leukemia Cell Apoptosis by Oxidative Stress." Blood 118, no. 21 (November 18, 2011): 4304. http://dx.doi.org/10.1182/blood.v118.21.4304.4304.

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Abstract Abstract 4304 The present study evaluated on the safe concentration for normal monocyte cells whether the magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) could induce caspase3-dependent apoptosis in SKM1 cells and U937 cells by oxidative damage. The average sizes of the particles were carefully determined by transmission electron microscopy. The viability of the cells after exposed to different concentration MNPs-Fe3O4 for 12h, 24h, 48h and 72h were detected by trypan blue staining. Cell cycle after exposure for 72h was analysed by propidium iodide (PI) staining. Apoptosis of MNPs-Fe3O4 group were detected and determined by Annexin V-FITC/PI double staining, 5,5’,6,6’-tetrachloro-1, 1’,3,3’-tetraethylbenzimidazolylcarbocyanine iodide (JC-1) probe and Wright - Giemsa staining. ROS in SKM1 cells and U937 cells after exposure were determined by flow cytometry after dichlorofluoroescein diacetate (DCFH-DA) staining. The changes of caspase3, survivin and bcl-rambo in the cells treatment with MNPs-Fe3O4 with or wtihout trolox for 48 hours were detected by western blot analysis. The significant decreased of cell viability caused by 100 μ M MNPS-Fe3O4 exposure were observed in SKM1 cells and u937 cells, not in normal monocytes cells (p < 0.05), the exposure also induced the SKM1 cells and u937 cells G0/G1 arrest (p < 0.05). Annexin V / PI staining assay show that 100 μ M MNPs-Fe3O4 group appeared more apoptosic rate in the U937 and SKM1 cells than the control group (p < 0.05), and on the same exposed concentration the apoptotic bodies could be frequently found in the U937 and SKM1 cells, while not in normal monocyte cells by Wright - Giemsa staining. The mitochondrial membrane potential in the two kinds of cells significantly decreased after exposed 100 μ M MNPs-Fe3O4 for 24h (p < 0.05), while pretreated with antioxidants trolox, the change was allevated (p < 0.05). DCFH-DA assay show that reactive oxygen species (ROS) generation increased in 6h of exposure in SKM1 cells and U937 cells (p < 0.05). Our results also showed the particle induced caspase3-dependent apoptosis in the SKM1 cells and U937 cells, while did not in normal monocyte cells, and increasing expression of bcl-rambo and decreasing expression of survivin involve in the process. These results suggest that on the safe concentration for normal monocyte cells MNPs-Fe3O4 could induce caspase3-dependent apoptosis in SKM1 cells and U937 cells by oxidative damage, moreover, increasing expression of bcl-rambo and decreasing expression of survivin involve in the process. Disclosures: No relevant conflicts of interest to declare.

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19

Pedersen, Pernille Steen. "Skam æder anerkendelser op – præsentation af et skjult ledelsesproblem ved stress." Samfundslederskab i Skandinavien 34, no. 1 (March 5, 2019): 26–41. http://dx.doi.org/10.22439/sis.v34i1.5668.

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Denne artikel præsenterer skam som et nyt og skjult ledelsesproblem. Med afsæt i kvalitative interviews fra to forskellige forskningsprojekter viser jeg, hvordan skam dukker op i et moderne arbejdsliv i forbindelse med stress. Efter at have præsenteret forskningsprojekterne og min analysetilgang, viser jeg forskellige situationer, hvori skamfølelsen dukker op som et ledelsesproblem. Herefter introduceres to reaktionsmønstre på skam som afsæt til, at jeg afslutningsvis kan pege på relationen og kommunikationen mellem leder og medarbejder samt kollegaer indbyrdes som stedet, hvor skamfølelsen kan håndteres med henblik på at forebygge yderligere forværring af skam. Målet med artiklen er at kaste lys over en ny problemstilling i forbindelse med stress, som jeg fortsat er i gang med at udforske. Artiklen skal betragtes som en invitation til at få indblik i en opdagelsesrejse, med de forbehold det nu engang indebærer. Jeg håber, at læseren vil tage med på rejsen og bruge den præsenterede viden som inspiration til eget arbejde – frem for at betragte den som en fiks og færdig teori.

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20

Wigal, Sharon B., Seth C. Hopkins, Kenneth S. Koblan, Ann Childress, Justine M. Kent, Joyce Tsai, Jay Hsu, Antony Loebel, and Robert Goldman. "Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study." Journal of Attention Disorders 24, no. 2 (August 2, 2019): 192–204. http://dx.doi.org/10.1177/1087054719864644.

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Objective: To evaluate the efficacy and safety of dasotraline for treatment of ADHD in children. Method: Children (ages 6-12 years; N = 112) with ADHD were randomized, double-blind, to 14 days of once-daily evening doses of dasotraline 4 mg or placebo. ADHD symptom severity was measured at baseline and Day 15 in seven, 30-min classroom sessions using the Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP) and the Permanent Product Measure of Performance (PERMP) math test. Results: Significant improvement was observed for dasotraline versus placebo in the SKAMP-combined score (−3.2 vs. +2.0; p < .001; effect size = 0.85) and SKAMP and PERMP subscale scores. The three most common adverse events for dasotraline (vs. placebo) were insomnia (19.6% vs. 3.6%), headache (10.7% vs. 8.9%), and decreased appetite (10.7% vs. 3.6%). Conclusion: In this laboratory classroom study, dasotraline 4 mg was found to be an efficacious and generally well-tolerated treatment for ADHD in children aged 6 to 12 years.

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21

Cluzeau, Thomas, Guillaume Robert, Jean-Michel Karsenti, Frederic Luciano, Alexandre Puissant, S. Dominique Raynaud, Lionel Mannone, Jill-Patrice Cassuto, Nicolas Mounier, and Patrick Auberger. "Induction of Autophagic Cell Death Circumvents Azacitidine-Resistance In Myelodysplastic Syndrome-Derived Cell Lines." Blood 116, no. 21 (November 19, 2010): 1817. http://dx.doi.org/10.1182/blood.v116.21.1817.1817.

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Abstract Abstract 1817 Azacitidine (AZA) is the first line treatment for IPSS (index prognostic scoring system) high-risk myelodysplastic syndrome (HR-MDS). To date, only Khan et al. (Exp Hematol. 2008) and Hollenbach et al. (PLoS One. 2009) have reported apoptosis as a mechanism of AZA effect on MDS cell lines. Nevertheless, approximately 40% of patients treated with AZA are refractory to this molecule. To investigate the possible mechanisms of AZA resistance in MDS cells, we developped AZA-resistant cell clones (AZA-R) from the well-characterized MDS cell line SKM1. The bulk resistant SKM1 cell line (AZA-R) was obtained following long time exposure of cells to iterative and increasing doses of AZA ranging from 0.1 to 8mM. We first showed that AZA triggered loss of cell metabolism in SKM1 parental cells but not in their AZA-resistant counterpart at a maximally effective dose of 1mM. AZA-mediated loss of cell metabolism accounted mainly for induction of apoptosis as judged by both an increase in caspase 9 and 3 activities triggered by this compound and by a significant protection in the presence of the pan-caspase inhibitor Z-VAD-fmk in SKM1 parental cells. Conversely, no or very few activation of caspases and apoptosis were detected in AZA-R cells strongly suggesting that apoptosis is impaired in AZA-R SKM1 cells. Finally, unlike in SKM1 cells, AZA failed to induce mitochondrial membrane permeabilization in AZA-R SKM1 cells. Importantly, basal autophagy was increased in AZA-R versus AZA-S cells as shown by LC3-I cleavage into LC3-II, p62/SQSTM1 protein expression, cathepsin B activation, mTOR and S6 ribosomal protein dephosphorylation and finally electronic microscopy experiments. In addition, Acadesine, an adenosine derivative and AMPK agonist which targets autophagy was capable to circumvent AZA resistance in both AZA-R SKM1 cells and in medullary cells from five MDS patients resistant to AZA after 6 cycles of Azacitidine. In conclusion, targeting autophagy appears as an attractive therapeutical strategy to circumvent AZA resistance in both established MDS cell lines and cells from MDS patients. Therefore, drugs capable of inducing autophagy or autophagic cell death, such as Acadesine (Robert et al., PLoS One. 2009) which is currently in phase II clinical trials for the treatment of Chronic Lymphoblastic Leukemia could be also beneficial for HR-MDS patients resistant to AZA. Disclosures: Cluzeau: Celgene: Consultancy. Raynaud:Celgene: Consultancy.

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22

Glavind Bo, Inger. "Det sociale bånd og følelser i menneskers interaktion Thomas Scheffs socialpsykologiske perspektiv på stolthed og skam." Psyke & Logos 33, no. 1 (July 31, 2012): 20. http://dx.doi.org/10.7146/pl.v33i1.8771.

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I artiklen vil jeg redegøre for og diskutere socialpsykologen Thomas Scheffs teori om det sociale bånd, stolthed og skam, hvor fokus vil være på skamfølelsen, for herved at udfolde konsekvenserne af et sådant fokus i forståelsen af den sociale interaktion. Thomas Scheff udnævner skammen til at være den hyppigst forekommende og mest centrale følelse, idet den skabes i interaktionen via den kontinuerlige selvovervågning og -vurdering på grundlag af andres værdsættelse eller miskreditering (Scheff, 1990, 79; pp. 169-171). Det er blandt andet denne argumentation, jeg vil udfolde i artiklen ved at tage fat i specielt tre af Scheffs væsentligste inspirationskilder: 1) Goffman og dennes særlige blik for følelsesdynamikker i interaktionen – specielt forlegenhed/pinlighed, 2) C. H. Colleys teori om det sociale spejlselv og de selvmonitorerende processer, der leder til følelser af henholdsvis stolthed eller skam og 3) den psykoanalytiske forsker Helen Lewis’ begreb: følelsesfælder samt hendes sondring mellem den åbne, udifferentierede skam og omledt skam. Begge typer skamfølelse er uerkendte og skjulte. I artiklen vil jeg på baggrund af Scheffs og Suzanne Retzingers fælles og individuelle arbejder desuden skitsere, hvordan disse sociale følelser influerer på menneskers sociale liv, og hvordan studiet heraf kan give en dybere indsigt i dysfunktionel kommunikation og interpersonelle konflikter. Scheffs teori om det sociale bånd, stolthed og skam rummer også en kobling mellem mikro- og makroniveau. Internationale konflikter tolker Scheff i lyset af det mønster, han karakteriserer som en skam-vredespiral. Han trækker således en parallel mellem konflikteskalering på det mellemmenneskelige niveau i familier og internationale konflikter på et makroniveau. Afslutningsvis vil jeg inddrage et eksempel på en sådan parallel via Scheffs analyser af Hitlers magtovertagelse i Tyskland og 2. verdenskrigs udbrud. Herved tydeliggøres, hvordan perspektivet kan bidrage med væsentlig indsigt i problemstillinger på makroniveau.

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23

Bakken, Runar. "Alderdom - en hemmelig skam." Nytt Norsk Tidsskrift 31, no. 04 (November 26, 2014): 465–75. http://dx.doi.org/10.18261/issn1504-3053-2014-04-08.

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24

Marstein, Trude. "Sex, skam og ensomhet." Samtiden, no. 04 (March 10, 2014): 74–92. http://dx.doi.org/10.18261/issn1890-0690-2013-04-06.

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Grodal, Torben Kragh. "Skam, latter og kønskamp." K&K - Kultur og Klasse 15, no. 58 (April 28, 1987): 63–78. http://dx.doi.org/10.7146/kok.v15i58.20746.

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Christensen, Christa Lykke. "SKAM som social utopi." K&K - Kultur og Klasse 46, no. 125 (May 15, 2018): 139–56. http://dx.doi.org/10.7146/kok.v46i125.105554.

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Анотація:

In this article I discuss the Norwegian teen drama series Shame, broadcast by the public service broadcaster NRK 2015-2017. In the Scandinavian countries the series was targeted to a young audience around 16 years old but it became extremely popular among viewers of all ages, among men and women, and moreover, streaming made it available globally. The article discusses TV production for a youth audience within a public service and a commercial media system. The argument is that the series, expressing the ethos of social responsibility of Scandinavian public service broadcasting, represents a social utopia and that it in several ways has much in common with the long tradition for Scandinavian realistic drama production for young audiences. Thus, the article argues that the drama series of Shame is based on a narrative of inclusion – in contrast to popular TV-shows for a young audience on commercial channels, for instance reality gameshows, which are often based on a narrative of exclusion. The theoretical framework draws on Erving Goffman’s micro-sociological considerations of the social dramaturgy of face work, and is inspired by the theory of recognition by Axel Honneth. Analytically, the face work and interactions of the main characters of the Shame-series are used to exemplify how the drama series creates a narrative of inclusion while addressing critical issues such as face loss, emotional rejections, and shame. In conclusion, the series is an example of successful public service programming that is able to address young people.

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Imerslund, Bente. "Fra skam til stolthet." Samtiden 130, no. 4 (November 24, 2021): 36–49. http://dx.doi.org/10.18261/issn1890-0690-2021-04-06.

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Bråtane, Katrine. "Skam ved plutselig funksjonstap." Tidsskrift for Den norske legeforening 132, no. 8 (2012): 1052. http://dx.doi.org/10.4045/tidsskr.12.0100.

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Bachmann, Anne. "Hankering for iconic moments: Transduction and representation in Skam fans’ anticipations about the remake Skam Austin." Journal of Scandinavian Cinema 11, no. 1 (March 1, 2021): 133–47. http://dx.doi.org/10.1386/jsca_00043_1.

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The Norwegian web series Skam (2015‐17) has been remade several times, but the American version Skam Austin (2018‐19) has a particular standing as an adaptation because its first season was produced by the original showrunner. The article considers fans’ views of the choices made in the remake and the contextual shifts informing these choices, i.e. their views of the so-called cultural transduction. It argues that the fan discourse around Skam Austin thrives on discussing the transduction in itself, because long-standing fans dominate the discourse and because the show’s depictions of teenage life-worlds are expected to have high realistic ambitions. Comments from fans reveal that much of their enjoyment of Skam Austin resided in expectations about specific ‘remade moments’. Such moments typically express a spirit of social resistance and are, if successful, celebrated as iconic. In the politicized American media climate of the day, ‘remade moments’ that particularly engaged fans focused on representation issues concerning gender and race, such as intersectional identities and awareness about sexual harassment.

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Sánchez, Alba Montes. "Er skam en moralsk følelse? En sammenligning af individuel og gruppebaseret skam." K&K - Kultur og Klasse 46, no. 125 (May 15, 2018): 49–70. http://dx.doi.org/10.7146/kok.v46i125.105538.

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Is shame a moral emotion? After the Muhammad cartoons controversy, many Danes argued that freedom of speech should be limited by a sense of decency, that insulting Islam for the sake of insult was shameful. Ten years later, the Danish government’s anti-refugee policy led some to say they were ashamed of being Danish. Here shame is given moral significance as the guardian of decency. However, psychologists like Tangney and Dearing have claimed that shame is morally counter-productive: it makes us react in antisocial ways, covering up our failings, shunning contact with others or lashing out in anger. Some have recently argued that the rise of right-wing populism in many Western nations is fueled by the psychological mechanism of transforming shame into rage. This seems a case of shame backfiring to cause antisocial behavior. In this paper, I seek to illuminate this dilemma by analyzing how self and others relate in shame. I defend that shame is an emotion of social self-consciousness, where one’s own self-assessment is fundamentally mediated by others. It may pull us in moral and immoral directions, but it is anyway part of the sensibilities that make us moral. My central examples, though, are cases of group-based shame. Is shame equally appropriate, and does it have the same significance, when it is group-based? I argue that the conditions of appropriateness change, but the structure of the emotion and its moral significance remains unchanged.

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Ballotti, Alessandra. "De SKAM et de Skam France : la fiction entre intertextualité et transfert." Nordic Journal of Francophone Studies/Revue nordique des études francophones 3, no. 1 (2020): 84–94. http://dx.doi.org/10.16993/rnef.37.

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Mellema, Garrelt, Sambit Giri, and Raghunath Ghara. "Analysis of 21-cm tomographic data." Proceedings of the International Astronomical Union 12, S333 (October 2017): 26–29. http://dx.doi.org/10.1017/s1743921318000716.

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AbstractThe future SKA1-Low radio telescope will be powerful enough to produce tomographic images of the 21-cm signal from the Epoch of Reionization. Here we address how to identify ionized regions in such data sets, taking into account the resolution and noise levels associated with SKA1-Low. We describe three methods of which one, superpixel oversegmentation, consistently performs best.

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Johansen, Stine Liv, and Lone Koefoed Hansen. "S[k]amtaler : Om etnografisk metode og forskerpositioner." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 89–98. http://dx.doi.org/10.7146/ntik.v6i2.99087.

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Researching a phenomenon like the Norwegian TV-series SKAM further complicates the inside-outside notion already debated within ethnographic methods. With SKAM, the reception takes place in a multi-platform and always-on environment: the fan culture(s) happen(s) across several online platforms and the series makes use of a particular understanding of 'liveness' when it updates the story throughout the week, at random times, and on several platforms. This directly influences a researcher's positioning and modes of action. In this paper, we discuss the act of researching SKAM through analysing empirical data from our conversation on Messenger in which we—in the eight months it lasted—acted both as fans or viewers and as researchers aiming to understand SKAM's fandom. In this case of an continuously updating narrative that seems to happen in a parallel universe to our everyday life, what might 'being-there' entail for researchers?, we ask. The methodological perspectives thus discussed here relate to auto-ethnography as well as to media-ethnography, allowing us to discuss how SKAM was a phenomenon that interfered into our professional but definitely also into our private lives.

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Mureșan, Ioana-Andreea, and Raluca Pop. "The Use of English in SKAM. Exploring Authentic Resources in Learning Norwegian at BA Level at Babe?-Bolyai University." Educatia 21, no. 21 (December 14, 2021): 183–92. http://dx.doi.org/10.24193/ed21.2021.21.19.

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The goal of this paper is to explore how the use of the popular Norwegian web-based TV series SKAM (SHAME) can enhance cultural awareness by exposure to authentic language and to diverse discourse practices that have both a multilingual and a multicultural dimension. English, through the use of anglicisms and code-switching in SKAM, acts as a cohesive factor that reflects the changes within the Norwegian society while building bridges between different cultures because of its global influence, particularly upon the younger generations. These generations no longer perceive English as a foreign language, but rather as an essential part of their personal and collective identity, and this is reflected in their discourse practices. The analysis of the teenage informal discourse in the series SKAM provides insights into the benefits of using authentic resources to acquaint BA students with the Norwegian contemporary culture.

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Masala, Erico, Ana Belén Valencia, Alessandro Sanna, Alice Brogi, Laila Zaroili, and Valeria Santini. "Resistance to Azacitidine Is Determined at Cellular Level By Lower Expression of Nucleoside Metabolizing Enzymes." Blood 128, no. 22 (December 2, 2016): 5129. http://dx.doi.org/10.1182/blood.v128.22.5129.5129.

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Abstract Introduction: Azacitidine is at present the standard of treatment of myelodysplastic syndromes (MDS). We demonstrated that MDS patients responsive to azacitidine have significantly higher expression of the azacitidine-activating enzyme uridine-cytidine kinase-1 (UCK1) in bone marrow mononuclear cells (Valencia et al. Leukemia 2014). Correlation of the expression of nucleoside transporter, activating and disactivating enzymes with clinical and in vitro response to hypomethylating drugs azacitidine and decitabine has been suggested by several authors. Yet, the crucial role of these enzymes has to be ascertained, as well as their possible different importance in determining resistance. Objectives: To confirm that the cellular expression of nucleoside metabolizing enzymes plays a major role in cellular resistance and significantly impacts on clinical response to azacitidine. Methods: Two cell lines, SKM1 sensitive (SKM1-S) and SKM1 resistant (SKM1-R) to azacitidine (Cluzeau et al. Oncogene 2014) were analyzed for expression of UCK1, UCK2, hENT1, hCNT3, RRM1 and RRM2 by quantitative PCR, using an ABI GeneAmp® 5700. The specific oligonucleotides and TaqMan® probes were acquired among the Assay-on-Demand® Gene Expression Products (Applied Biosystems). Corresponding proteins were quantitated by western blotting in both cell lines. The expression of UCK1 and UCK2 was blunted by siRNAs in order to determine their role in in vitro sensitivity to azacitidine. For UCK2 silencing in SKM1-S, specific siRNAs were used (OriGene Technologies, Inc., Rockville, MD, USA). SKM1-S cells were cultured at a density of 1x106 cells/ml in 9 ml of RPMI 1940 medium. After 72 h of transfection, cells were treated for further 48h with azacitidine at the concentrations of 0,1 and 1 μM. After assessment of effective gene silencing, apoptosis and DNA methylation were evaluated by Annexin V test, MSP and pyrosequencing in cells exposed to azacitidine. In addition, the expression of nucleoside metabolizing enzymes was evaluated prospectively in IPSS high risk MDS patients treated with azacitidine 75mg/m2/7 days every 28 days. Results: SKM1-R cells did not express UCK1, UCK2, hENT1, hCNT3, RRM1 and RRM2. Corresponding proteins were also not expressed. In order to clarify the specific role of UCK2 protein in the mechanisms of resistance to azacitidine, we knocked-down UCK2. A reduction of apoptosis was observed in UCK2-silenced SKM-1 S after azacitidine 0.1 μM treatment: 31%±0,85% Annexin V-positive cells versus 21%±0,35% in non-silenced control SKM1-S cultures (P= 0.054). Hypomethylation induced by in vitro azacitidine treatment was also hampered by absence of expression of UCK2. Quite surprisingly, in MDS cases, gene expression of UCK1, UCK2, hENT1, hCNT3, RRM1 and RRM2 in primary cellsdid not predict different clinical response to azacitidine. Conclusions: We demonstrated that UCK1, UCK2, hENT1, hCNT3, RRM1 and RRM2 and the corresponding proteins are absent in an in vitro generated azacitidine-resistant cell line SKM1-R. These abnormalities could be major determinants of the induced resistance to the nucleoside analogue. Supporting the importance of these enzymes in resistance to nucleosides, and the major role played by UCK2, its silencing induced by synthetic siRNAs significantly decreased azacitidine effects. Prospective evaluation of the predictive role of cellular expression of genes involved in azacitidine metabolism is ongoing in a larger cohort of MDS patients. Establishing the mechanisms of resistance to azacitidine could lead us to optimize treatment of MDS patients whose scarce susceptibility could be predictable. Disclosures Santini: Celgene: Consultancy, Honoraria, Research Funding; Amgen: Other: advisory board; Novartis: Consultancy, Honoraria; Onconova: Other: advisory board; Janssen: Consultancy, Honoraria; Astex: Other: advisory board.

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Bissenbakker, Mons, and Michael Nebeling Petersen. "”Det er bare du, som kan føle det, du føler”: Skrøbelighed og queer alliancer i SKAMs Sæson 3." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 21–26. http://dx.doi.org/10.7146/ntik.v6i2.99057.

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Analysing the series SKAM through an affective queer, crip, and antiracist reading strategy this article shows how SKAM re-politicizes the otherwise gay clichés the series touches upon; thus, the series present anything but a so-called “universal love story”. Rather, it offers a seldom seen queer eye for everyday homophobia as well as a possibility for alternative alliances among queers, crips, and secularism-criticals; alliances that move through as well as beyond the Feminist Killjoy.

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Kando, Judith C., Thomas King, Antonio Pardo, and Barry K. Herman. "88 The Efficacy and Safety of Amphetamine Extended-Release Oral Suspension (AMPH EROS) in Children with Attention-Deficit/Hyperactivity Disorder." CNS Spectrums 24, no. 1 (February 2019): 219–20. http://dx.doi.org/10.1017/s109285291900066x.

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AbstractOBJECTIVESTo determine the efficacy and safety of amphetamine extended-release oral suspension (AMPH EROS) in the treatment of attention-deficit/hyperactivity disorder (ADHD) compared with placebo in a dose-optimized, randomized, double-blind study.METHODSThe efficacy of AMPH EROS was evaluated in a laboratory classroom study conducted in 108 pediatric patients (aged 6–12 years) with ADHD. The study began with an open-label dose optimization (5weeks) with an initial AMPH EROS dose of 2.5 or 5mg once daily in the morning. The dose could be titrated every 4–7 days in increments of 2.5–10mg until an optimal dose or the maximum dose of 20mg/day was reached. Subjects were required to tolerate a minimal dose of 10mg/day. Subjects then entered a 1-week randomized, double-blind treatment phase with the individually optimized dose or placebo. At the end of the week, raters evaluated the attention and behavior of the subjects in a laboratory classroom using the Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP-C) rating scale. SKAMP-C is a 13-item teacher-rated scale that assesses manifestations of ADHD in a classroom setting.The primary efficacy endpoint was change from pre-dose in the SKAMP-C score at 4hours post dose. The key secondary endpoint efficacy parameters were onset and duration of clinical effect. The change scores from pre-dose SKAMP-C scores at post dose time points (1, 2, 6, 8, 10, 12 and 13hours) were used to evaluate the key secondary efficacy endpoints.RESULTSMore boys (68.7%) than girls participated in the study. The study population was 55.6% white, most patients had inattentive or combined type ADHD presentations. The primary efficacy endpoint, the change from pre-dose SKAMP-C score at 4hours post dose was statistically significantly improved (p<0.0001) compared with placebo. Each of the secondary efficacy endpoints were also significantly improved (p<0.0001 at each time point) compared with placebo. Adverse events reported (frequency >5%) reported during the dose optimization phase were decreased appetite, insomnia, affect lability, upper abdominal pain, mood swings, and headache.CONCLUSIONSAMPH EROS was effective in reducing symptoms or ADHD from 1 to 13hours after dosing. Adverse events reported were consistent with those of other amphetamine products.Funding Acknowledgements: This study was supported by Tris Pharma, Inc.

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Bekkevold, Juliane Killerud, and Ole Kolbjørn Kjørven. "Om religion, identitet og SKAM." Kirke og Kultur 124, no. 02 (June 25, 2020): 166–78. http://dx.doi.org/10.18261/issn.1504-3002-2020-02-08.

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Oxfeldt, Elisabeth, and Devika Sharma. "Skyld og skam i Skandinavien." K&K - Kultur og Klasse 46, no. 125 (May 15, 2018): 1–12. http://dx.doi.org/10.7146/kok.v46i125.105536.

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Storm Villadsen, Lisa. "Fy, skam dig ikke! Skam som sanktioneret og konstruktiv følelse i den offentlige debat." Rhetorica Scandinavica 22, no. 78 (December 1, 2018): 75–86. http://dx.doi.org/10.52610/mrsp5084.

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This article contributes to scholarship on emotions in political rhetoric by way of complicating commonly held views on which types of emotions are appropriate in public debate. The article examines the feeling shame from two perspectives, each rhetorically and critically oriented: one is analytical, the other theoretical. The case material comes from Danish politics where a group of celebrities stated to the press that they felt ashamed on account of Denmark’s policy regarding refugees and immigrants. Based in analysis of the public reaction from the Prime Minister I show how the feeling shame and those who felt it were marked as inappropriate from public debate. In the latter part of the article I theorize on negative emotions and shame in public rhetoric. Drawing on contemporary political philosophy and feminist and queer theory I argue for a more nuanced view on appeals to the emotion shame. Closer reflection suggests that it does not necessarily imply the destructive social distancing one would ordinarily expect but that it has potential as a marker of solidarity with the collective and as such can drive ethical reconsideration

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Boink, Gerard J. J., David H. Lau, Iryna N. Shlapakova, Eugene A. Sosunov, Evgeny P. Anyukhovsky, Helen E. Driessen, Wen Dun, et al. "SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic." Cardiovascular Research 94, no. 3 (February 27, 2012): 450–59. http://dx.doi.org/10.1093/cvr/cvs107.

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Bengtsson, Emelie, Rebecka Källquist, and Malin Sveningsson. "Combining New and Old Viewing Practices." Nordicom Review 39, no. 2 (December 31, 2018): 63–77. http://dx.doi.org/10.2478/nor-2018-0012.

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Abstract In 2015, the Norwegian Broadcasting Corporation (NRK) released a new youth series, Skam, which was acclaimed for its accurate portrayal of Norwegian teenagers but, above all, for its distribution as a transmedia narrative spreading content across several platforms. Through focus-group interviews, this article investigates how Swedish Skam viewers took part in the content and perceived the role and relation between the platforms. While the interviewees followed Skam in different ways, they nevertheless accepted and appreciated the transmedia format. While they argued that the core content needed to be video based, other content was also seen as a natural part of the series and essential in building the narrative. Furthermore, the idea of contemporary media consumption as being less constrained by time and space was partly contradicted. Especially real-time content and discussions with peers motivated the participants to abide by a new kind of TV schedule, reminiscent of TV viewing practices of the past.

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Chan, Ying Wai, A. Arockia Jeyaprakash, Erich A. Nigg, and Anna Santamaria. "Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction." Journal of Cell Biology 196, no. 5 (February 27, 2012): 563–71. http://dx.doi.org/10.1083/jcb.201109001.

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The KMN network (named according to the acronym for KNL1, Mis12, and Ndc80) and the more recently identified Ska complex (Ska1–3) have been shown to mediate kinetochore (KT)–microtubule (MT) attachments. How these two complexes cooperate to achieve stable end-on attachments remains unknown. In this paper, we show that Aurora B negatively regulates the localization of the Ska complex to KTs and that recruitment of the Ska complex to KTs depends on the KMN network. We identified interactions between members of the KMN and Ska complexes and demonstrated that these interactions are regulated by Aurora B. Aurora B directly phosphorylated Ska1 and Ska3 in vitro, and expression of phosphomimetic mutants of Ska1 and Ska3 impaired Ska KT recruitment and formation of stable KT–MT fibers (K-fibers), disrupting mitotic progression. We propose that Aurora B phosphorylation antagonizes the interaction between the Ska complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT–MT attachments.

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Hartmann Rasmussen, Ida Malene, and Bjarki Valtysson. "At føle meget : Affektive relationer i SKAM fanfællesskaber." Nordisk Tidsskrift for Informationsvidenskab og Kulturformidling 6, no. 2 (November 28, 2017): 99–104. http://dx.doi.org/10.7146/ntik.v6i2.99092.

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This article investigates SKAM’s transmedia storytelling with specific focus on the affective relations between fans on the SKAM blog (http://skam.p3.no). Empirically, the article is based on data extracted from a focus group conducted with SKAM-fans and a qualitative content analysis of the communication found in the commentary section on the blog. Results indicate that SKAM’s strategic use of transmedia storytelling is experienced by fans as authentic, and contributes to the emergence of affective online publics, where emotions and feelings run high.

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Goldman, Robert, Ann Childress, Sharon B. Wigal, Seth C. Hopkins, Kenneth S. Koblan, Kaushik Sarma, Jay Hsu, and Antony Loebel. "180 Efficacy of Dasotraline in Children With Attention Deficit Hyperactivity Disorder in a Laboratory Classroom Setting." CNS Spectrums 23, no. 1 (February 2018): 103. http://dx.doi.org/10.1017/s1092852918000627.

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AbstractObjectivesOnce-daily dosing with dasotraline, a novel dopamine and norepinephrine reuptake inhibitor, achieves stable plasma concentrations over 24 hours. This phase 3 study evaluated the efficacy and safety of dasotraline in children with attention deficithyperactivity disorder (ADHD) throughout the day, in a laboratory classroom setting (NCT02734693).MethodsChildren (6–12 years) meeting DSM-5 criteria for ADHD were randomized to 2 weeks of dasotraline or placebo (dosed daily at home at approximately 8 PM). Following an abbreviated practice day, laboratory classroom evaluations took place at baseline and on Day 15. The primary endpoint was mean change from baseline at Day 15 in ADHD symptoms, as measured by the Swanson, Kotkin, Agler, M-Flynn, and Pelham Combined Score (SKAMP-CS), obtained from the average of 7 assessments collected across the 12-hour laboratory classroom day (12–24 hours post-dose). Secondary endpoints included SKAMP scores obtained throughout the day at individual timepoints from 8 AM through 8 PM (12–24 hours post-dose), and measures of safety and tolerability.ResultsThe ITT population comprised 112 patients. Mean age was 9.5 years, 68.8% were male; 92% completed the study. Dasotraline 4 mg/day significantly improved mean SKAMP-CS versus placebo (p<0.0001, effect size 0.85) with significant effects persisting throughout the day. Mean SKAMP subscores improved significantly versus placebo (Attention p<0.0001, effect size 0.81; Deportment p<0.001, effect size 0.70). Treatment-emergent adverse events were generally mild or moderate in severity; most frequent (with dasotraline 4 mg/day; placebo) included: insomnia (19.6%; 3.6%, all terms combined), decreased appetite (10.7%; 3.6%), headache (10.7%; 8.9%), affect lability (8.9%; 7.1%), irritability (5.4%; 3.6%), postural orthostatic tachycardia syndrome (5.4%; 0%), and perceptual disturbances (5.4%; 0%).ConclusionsIn this 2-week, randomized, double-blind, laboratory classroom study in children with ADHD, once-daily dasotraline significantly improved ADHD symptoms (including deportment and attention), compared with placebo, and demonstrated sustained efficacyup to 24 hours post-dose. The most common adverse events were insomnia, decreased appetite, and headache.Funding AcknowledgementsStudy sponsored by Sunovion Pharmaceuticals Inc.

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Witzemann, Amadeus, Alkistis Pourtsidou, and Mario G. Santos. "Prospects for cosmic magnification measurements using H i intensity mapping." Monthly Notices of the Royal Astronomical Society 496, no. 2 (June 5, 2020): 1959–66. http://dx.doi.org/10.1093/mnras/staa1578.

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ABSTRACT We investigate the prospects of measuring the cosmic magnification effect by cross-correlating neutral hydrogen intensity mapping (H i IM) maps with background optical galaxies. We forecast the signal-to-noise ratio for H i IM data from SKA1-MID and HIRAX, combined with LSST photometric galaxy samples. We find that, thanks to their different resolutions, SKA1-MID and HIRAX are highly complementary in such an analysis. We predict that SKA1-MID can achieve a detection with a signal-to-noise ratio of ∼15 on a multipole range of ℓ ≲ 200, while HIRAX can reach a signal-to-noise ratio of ∼50 on 200 < ℓ < 2000. We conclude that measurements of the cosmic magnification signal will be possible on a wide redshift range with foreground H i intensity maps up to z ≲ 2, while optimal results are obtained when 0.6 ≲ z ≲ 1.3. Finally, we perform a signal to noise analysis that shows how these measurements can constrain the H i parameters across a wide redshift range.

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Antonioni, Stefania, Luca Barra, and Chiara Checcaglini. "‘SKAM Italia did it again’. The multiple lives of a format adaptation from production to audience experience." Critical Studies in Television: The International Journal of Television Studies 16, no. 4 (December 2021): 433–54. http://dx.doi.org/10.1177/17496020211049363.

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SKAM Italia, the Italian version of the Norwegian SKAM format, was first released in Spring 2018 and has reached its fourth season in May 2020, overcoming several industrial struggles and slowly engaging an increasing, young and local audience. This article aims to integrate a production–distribution and reception perspective, showing how they mutually reinforce the series’ identity: the peculiarity of SKAM’s distribution system fostered the audience’s engagement, until its complicated production history brought the series to a more conventional circulation. Mutual exchanges between professionals and audiences on a global level are always counterbalanced by national negotiations, influencing the series’ life cycle.

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Lin, Meng, Heike Unden, Nicolas Jacquier, Roger Schneiter, Ursula Just, and Thomas Höfken. "The Cdc42 Effectors Ste20, Cla4, and Skm1 Down-Regulate the Expression of Genes Involved in Sterol Uptake by a Mitogen-activated Protein Kinase-independent Pathway." Molecular Biology of the Cell 20, no. 22 (November 15, 2009): 4826–37. http://dx.doi.org/10.1091/mbc.e09-01-0034.

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In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis that are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized and need to be imported into cells. Here, we show that Ste20, Cla4, and Skm1 form a complex with Sut1, a transcriptional regulator that promotes sterol uptake. All three PAKs can translocate into the nucleus and down-regulate the expression of genes involved in sterol uptake, including the Sut1 targets AUS1 and DAN1 by a novel mechanism. Consistently, deletion of either STE20, CLA4, or SKM1 results in an increased sterol influx and PAK overexpression inhibits sterol uptake. For Ste20, we demonstrate that the down-regulation of gene expression requires nuclear localization and kinase activity of Ste20. Furthermore, the Ste20-mediated control of expression of sterol uptake genes depends on SUT1 but is independent of a mitogen-activated protein kinase signaling cascade. Together, these observations suggest that PAKs translocate into the nucleus, where they modulate expression of sterol uptake genes via Sut1, thereby controlling sterol homeostasis.

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Svendsen, Stine H. Bang, Elisabeth Stubberud, and Elise Farstad Djupedal. "Skeive ungdommers identitetsarbeid: SKAM etter homotoleransen." Tidsskrift for kjønnsforskning 42, no. 03 (September 10, 2018): 162–83. http://dx.doi.org/10.18261/issn.1890-7008-2018-03-03.

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Benestad, Esben Esther Pirelli. "Utdeling av synd, skam og kjønnsroller." Tidsskrift for psykisk helsearbeid 2, no. 02 (July 13, 2005): 196–99. http://dx.doi.org/10.18261/issn1504-3010-2005-02-13.

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