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Статті в журналах з теми "Single cell metabolic flux"
Wagner, Allon, Chao Wang, David DeTomaso, Arman Koul, Aviv Regev, Vijay K. Kuchroo, and Nir Yosef. "Cell-specific metabolic models reveal novel metabolic regulators of Th17 pathogenicity: from single-cell RNA-Seq to actionable metabolic targets." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 163.21. http://dx.doi.org/10.4049/jimmunol.200.supp.163.21.
Повний текст джерелаLand, S. C., D. M. Porterfield, R. H. Sanger, and P. J. Smith. "The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells." Journal of Experimental Biology 202, no. 2 (January 15, 1999): 211–18. http://dx.doi.org/10.1242/jeb.202.2.211.
Повний текст джерелаLee, Geonhui, Thomas Ruan, Claudia Wong, Kofi Deh, Alli Abolarin, Alexander Correa, Kayvan R. Keshari, and Sangmoo Jeong. "Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples." Bioengineering 10, no. 1 (December 21, 2022): 14. http://dx.doi.org/10.3390/bioengineering10010014.
Повний текст джерелаWagner, Allon, Chao Wang, David DeTomaso, Julian Avila Pacheco, Sarah Zaghouani, Johannes Fessler, Elliot Akama-Garren, et al. "In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 150.22. http://dx.doi.org/10.4049/jimmunol.204.supp.150.22.
Повний текст джерелаDai, David, Nicholas Horvath, and Jeffrey Varner. "Dynamic Sequence Specific Constraint-Based Modeling of Cell-Free Protein Synthesis." Processes 6, no. 8 (August 17, 2018): 132. http://dx.doi.org/10.3390/pr6080132.
Повний текст джерелаYasukawa, Tomoyuki, Andrew Glidle, Jonathan M. Cooper, and Tomokazu Matsue. "Electroanalysis of Metabolic Flux from Single Cells in Simple Picoliter-Volume Microsystems." Analytical Chemistry 74, no. 19 (October 2002): 5001–8. http://dx.doi.org/10.1021/ac025836u.
Повний текст джерелаGüell, Oriol, Francesco Alessandro Massucci, Francesc Font-Clos, Francesc Sagués, and M. Ángeles Serrano. "Mapping high-growth phenotypes in the flux space of microbial metabolism." Journal of The Royal Society Interface 12, no. 110 (September 2015): 20150543. http://dx.doi.org/10.1098/rsif.2015.0543.
Повний текст джерелаSengupta, Debanti, Amy Mongersun, Tae Jin Kim, Kellen Mongersun, Rie von Eyben, Paul Abbyad, and Guillem Pratx. "Multiplexed Single-Cell Measurements of FDG Uptake and Lactate Release Using Droplet Microfluidics." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381984106. http://dx.doi.org/10.1177/1533033819841066.
Повний текст джерелаChung, J., R. Clifford, G. Sriram, and C. Keefer. "68 Flux analysis of aerobic glycolysis in bovine blastocysts and CT1 cells." Reproduction, Fertility and Development 31, no. 1 (2019): 159. http://dx.doi.org/10.1071/rdv31n1ab68.
Повний текст джерелаDe Martino, A., D. Granata, E. Marinari, C. Martelli, and V. Van Kerrebroeck. "Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell." Journal of Biomedicine and Biotechnology 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/415148.
Повний текст джерелаДисертації з теми "Single cell metabolic flux"
Zupke, Craig Allen. "Metabolic flux analysis in mammalian cell culture." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/12661.
Повний текст джерелаFollstad, Brian D. (Brian David) 1972. "Metabolic flux analysis and population heterogeneity in mammalian cell culture." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/28218.
Повний текст джерелаIncludes bibliographical references (p. 189-206).
Metabolic flux and population heterogeneity analysis were used to develop relations between mammalian cell physiology and specific culture environments and to formulate strategies for increasing cell culture performance. Mitochondrial characteristics associated with respiration, membrane potential, and apoptosis along with physiological state multiplicity involving both metabolism and apoptotic death played a key role in this research. Research involving the accurate calculation of metabolic flux and the analysis of cellular behavior occurring in continuous cultures set the stage for subsequent research on physiological state multiplicity. This phenomena was observed in continuous cultures when at the same dilution rate, two physiologically different cultures were obtained which exhibited similar growth rates and viabilities but drastically different cell concentrations. Metabolic flux analysis conducted using metabolite and gas exchange rate measurements revealed a more efficient culture for the steady state with the higher cell concentration, as measured by the fraction of pyruvate carbon flux shuttled into the tri-carboxylic (TCA) cycle for energy generation. This metabolic adaptation was unlikely due to favorable genetic mutations and was implemented in subsequent research aimed at improving cell culture performance. A hypothesis stating that mitochondrial physiology and cellular physiology are correlated was tested and confirmed. A mammalian cell population was separated using FACS into subpopulations based on their mean mitochondrial membrane potential (MMP) as measured using the common mitochondrial stain, Rhodamine 123. The MMP sorted subpopulations were subjected to apoptosis inducers, and the apoptotic death was characterized both morphologically through the determination of apoptosis related chromatin condensation and also biochemically through the measurement of caspase-3 enzymatic activity. The results showed dramatic differences in apoptotic death kinetics with the higher MMP subpopulations demonstrating a higher resistance to apoptotic death. These results were applied in the development of novel fed-batch feeding and operating strategies. The first strategy showed that overfeeding cells later in culture leads to an increase in culture viable cell concentration, viability, and productivity. The second strategy showed that cell populations with a higher mean MMP are able to resist apoptosis during fed-batch culture. These results indicate that mammalian cell populations have considerable flexibility in their ability to redistribute metabolic flux in central carbon metabolism. Furthermore, these cell populations contain subpopulations that vary in their resistance to apoptotic death. The analysis of mitochondrial physiology and metabolic flux led to these discoveries, and these areas will play a key role in future mammalian cell culture research.
by Brian D. Follstad.
Ph.D.
Amaral, Ana Isabel Porém. "Metabolic flux analysis of neural cell metabolism in primary cultures." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/6849.
Повний текст джерелаBrain energy metabolism results from a complex group of pathways and trafficking mechanisms between all cellular components in the brain, and importantly provides the energy for sustaining most brain functions. In recent decades, 13C nuclear magnetic resonance (NMR) spectroscopy and metabolic modelling tools allowed quantifying the main cerebral metabolic fluxes in vitro and in vivo. These investigations contributed significantly to elucidate neuro-glial metabolic interactions, cerebral metabolic compartmentation and the individual contribution of neurons and astrocytes to brain energetics. However, many issues in this field remain unclear and/or under debate.
To the financial support provided by Fundação para a Ciência a Tecnologia (SFRH/BD/29666/2006; PTDC/BIO/69407/2006) and to the Clinigene – NoE (LSHBCT2006- 010933). I further acknowledge the Norwegian Research Council for a fellowship that allowed me to perform part of my PhD work at NTNU, Norway.
Waker, Christopher A. "Metabolic Characterization of MPNST Cell Lines." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1433182427.
Повний текст джерелаMetsger, Maria [Verfasser]. "Single-cell transcriptome analysis of metabolic stress response in macrophages / Maria Metsger." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1149050527/34.
Повний текст джерелаKarim, Khairiah Abd. "Study of factors that affect growth and taxol production in Taxus spp. cell cultures : application of metabolic flux analysis." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595834.
Повний текст джерелаOddsdóttir, Hildur Æsa. "Macroscopic Modeling of Metabolic Reaction Networks and Dynamic Identification of Elementary Flux Modes by Column Generation." Doctoral thesis, KTH, Optimeringslära och systemteori, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-172367.
Повний текст джерелаI denna avhandling betraktar vi korsningen mellan optimeringsmetoder och modellering av djurcellodling.Vi presenterar optimeringsbaserade metoder för att analysera och bygga modeller av cellkulturer. Dessa modeller kan användas vid konstruktionen av den miljö som cellerna ska odlas i, dvs, medium.Eftersom både mediet och cellinjen är komplexa är det inte okomplicerat att utforma ett bra medium. Att utveckla en modell av cellernas ämnesomsättning är ett steg för att underlätta designen av mediet. För att utveckla en modell av metabolismen kommer de metoder som används i detta arbete att utnyttja ett underliggande metaboliskt reaktions\-nätverk och extracellulära mätningar. Externa substrat och produkter är sammankopplade via de relevanta elementära metaboliska vägarna (EFM).Modellering med hjälp av EFM är i allmänhet begränsad till små nätverk eftersom antalet EFM exploderar när de underliggande nätverket ökar i storlek. Målet med detta arbete är att möjliggöra modellering med mer komplexa nätverk genom att presentera metoder som dynamiskt identifierar en delmängd av EFM. I artikel A och B betraktar vi en modell som består av EFM och ett flöde över varje EFM.I artikel A presenterar vi hur en sådan modell kan bestämmas med hjälp av en optimeringsteknik som kallas kolumngenerering.I artikel A undersöker vi hur robust en sådan modell är med avseende till mätfel. Vi visar att en robust version av det underliggande optimeringsproblemet i artikel A kan konstrueras samt att kolumngenerering kan appliceras för att identifiera EFM dynamiskt. Artikel C och D behandlar en kinetisk makroskopisk modell. Vi visar i artikel C hur en sådan modell kan konstrueras från EFM.Denna makroskopiska modell är skapad genom att anta att flödet genom varje EFM beter sig enligt Michaelis-Menten-typ av kinetik. Denna modelleringsmetod har förmågan att fånga cellernas beteende i olika typer av media, men storleken på nätverket är en begränsning.I artikel D hanterar vi denna begränsing genom att utveckla en approximationsalgoritm som identifierar EFM dynamiskt för en kinetisk modell.
QC 20150827
Westermayer, Sonja [Verfasser], and Joachim [Akademischer Betreuer] Rädler. "Single-cell time course analysis of metabolic switching in inducible gene regulatory networks / Sonja Westermayer ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1114068128/34.
Повний текст джерелаWestermayer, Sonja Verfasser], and Joachim [Akademischer Betreuer] [Rädler. "Single-cell time course analysis of metabolic switching in inducible gene regulatory networks / Sonja Westermayer ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1114068128/34.
Повний текст джерелаAdeyileka-Tracz, Bernadette Ayokunumi. "The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels." Thesis, Robert Gordon University, 2017. http://hdl.handle.net/10059/2713.
Повний текст джерелаКниги з теми "Single cell metabolic flux"
Metabolic flux analysis: Methods and protocols. New York: Humana Press, 2014.
Знайти повний текст джерелаShimizu, K. Bacterial Cellular Metabolic Systems: Metabolic Regulation of a Cell System with 13C-Metabolic Flux Analysis. Elsevier Science & Technology, 2013.
Знайти повний текст джерелаKromer, Jens O., Lars Nielsen, and Lars M. Blank. Metabolic Flux Analysis: Methods and Protocols. Springer New York, 2016.
Знайти повний текст джерелаBacterial Cellular Metabolic Systems Metabolic Regulation Of A Cell System With 13cmetabolic Flux Analysis. Woodhead Publishing, 2012.
Знайти повний текст джерелаMoney, Nicholas P. 1. Microbial diversity. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199681686.003.0001.
Повний текст джерелаWordsworth, B. P. Skeletal dysplasias. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0150.
Повний текст джерелаReber, Arthur S. The First Minds. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190854157.001.0001.
Повний текст джерелаЧастини книг з теми "Single cell metabolic flux"
Martens, D. E. "Metabolic Flux Analysis of Mammalian Cells." In Cell Engineering, 275–99. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/1-4020-5252-9_9.
Повний текст джерелаGoudar, Chetan T., Richard Biener, James M. Piret, and Konstantin B. Konstantinov. "Metabolic Flux Estimation in Mammalian Cell Cultures." In Animal Cell Biotechnology, 301–17. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-399-8_14.
Повний текст джерелаGoudar, Chetan T., Richard K. Biener, James M. Piret, and Konstantin B. Konstantinov. "Metabolic Flux Estimation in Mammalian Cell Cultures." In Animal Cell Biotechnology, 193–209. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-733-4_13.
Повний текст джерелаvan Gulik, Walter M., Wouter A. van Winden, and Joseph J. Heijnen. "Metabolic Flux Analysis, Modeling, and Engineering Solutions." In Handbook of Industrial Cell Culture, 349–92. Totowa, NJ: Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-346-0_15.
Повний текст джерелаSá, João V., Tiago M. Duarte, Manuel J. T. Carrondo, Paula M. Alves, and Ana P. Teixeira. "Metabolic Flux Analysis: A Powerful Tool in Animal Cell Culture." In Cell Engineering, 521–39. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10320-4_16.
Повний текст джерелаKrylov, Gleb, and Eby G. Friedman. "Sense Amplifier for Spin-Based Cryogenic Memory Cell." In Single Flux Quantum Integrated Circuit Design, 133–39. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76885-0_10.
Повний текст джерелаWu, Duojiao. "System Immunology in Metabolic Research of Dendritic Cells." In Single Cell Sequencing and Systems Immunology, 65–72. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9753-5_5.
Повний текст джерелаNiklas, Jens, and Elmar Heinzle. "Metabolic Flux Analysis in Systems Biology of Mammalian Cells." In Genomics and Systems Biology of Mammalian Cell Culture, 109–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/10_2011_99.
Повний текст джерелаVasdekis, A. E., and G. Stephanopoulos. "Single-Cell Phenotypic Screening in Inverse Metabolic Engineering." In Microfluidic Methods for Molecular Biology, 189–204. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30019-1_9.
Повний текст джерелаGoudar, Chetan, Richard Biener, Chun Zhang, James Michaels, James Piret, and Konstantin Konstantinov. "Towards Industrial Application of Quasi Real-Time Metabolic Flux Analysis for Mammalian Cell Culture." In Cell Culture Engineering, 99–118. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/10_020.
Повний текст джерелаТези доповідей конференцій з теми "Single cell metabolic flux"
Song, Ganquan, Rishabh M. Shetty, Haixin Zhu, Shashanka Ashili, Liqiang Zhang, Grace Kim, Andrew Shabilla, et al. "Multiple sensor arrays for single cell metabolic analysis." In 2013 IEEE Sensors. IEEE, 2013. http://dx.doi.org/10.1109/icsens.2013.6688453.
Повний текст джерелаXue, Min, Wei Wei, Yapeng Su, Young Shik Shin, Jungwoo Kim, and James R. Heath. "Abstract 1995: Developing integrated single-cell metabolic/proteomic assays." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1995.
Повний текст джерелаSuzuki, Masayasu, Hiroyuki Tanaka, and Yasunori Iribe. "Detection and collection system of target single cell based on respiration and metabolic activity." In 2009 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2009. http://dx.doi.org/10.1109/mhs.2009.5351919.
Повний текст джерелаGogolewski, Krzysztof, and Anna Gambin. "PCA-like Methods for the Integration of Single Cell RNA-seq Data with Metabolic Networks." In 2018 IEEE 8th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS). IEEE, 2018. http://dx.doi.org/10.1109/iccabs.2018.8542112.
Повний текст джерелаAshili, Shashanka P., Laimonas Kelbauskas, Jeff Houkal, Dean Smith, Yanqing Tian, Cody Youngbull, Haixin Zhu, et al. "Automated platform for multiparameter stimulus response studies of metabolic activity at the single-cell level." In SPIE MOEMS-MEMS, edited by Holger Becker and Bonnie L. Gray. SPIE, 2011. http://dx.doi.org/10.1117/12.875438.
Повний текст джерелаWu, D., D. Harrison, T. Szasz, C. F. Yeh, A. Y. Meliton, R. T. Huang, T. P. Shentu, et al. "Single-Cell Metabolic Imaging Reveals a Slc2a3/RhoA-Dependent Glycolytic Burst in Motile Endothelial Cells." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5748.
Повний текст джерелаAchreja, Abhinav, Hongyun Zhao, Ziwen Zhu, Jonathan Gerszberg, Marina Y. Konopleva, Michael Andreeff, and Deepak Nagrath. "Abstract 439: Metabolic flux analysis reveals targets to sensitize chemoresistance in acute myeloid leukemia induced by mesenchymal stromal cell-derived exosomes." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-439.
Повний текст джерелаWang, Fangzhou, and Sandeep Gupta. "Multi-cell characterization: Developing robust cells and abstraction for Rapid Single Flux Quantum (RSFQ) Logic." In 2019 IEEE International Test Conference (ITC). IEEE, 2019. http://dx.doi.org/10.1109/itc44170.2019.9000132.
Повний текст джерелаSawada, Kazunao, Tomoki Watanabe, Hiroshi Shimada, and Yoshinao Mizugaki. "Design and Operation of ROM-Dedicated Single-Flux-Quantum Cell Comprising Splitters and Confluence Buffers." In 2015 15th International Superconductive Electronics Conference (ISEC). IEEE, 2015. http://dx.doi.org/10.1109/isec.2015.7383443.
Повний текст джерелаDong, Guang, and Yulan Song. "Topology Optimization for the Single Phase Flow Using Two Point Flux Approximation Model." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65475.
Повний текст джерелаЗвіти організацій з теми "Single cell metabolic flux"
Dale, Taraka T. High Throughput Whole Cell Screening for Optimized Metabolic Flux. Office of Scientific and Technical Information (OSTI), November 2018. http://dx.doi.org/10.2172/1481959.
Повний текст джерелаPell, Eva J., Sarah M. Assmann, Amnon Schwartz, and Hava Steinberger. Ozone Altered Stomatal/Guard Cell Function: Whole Plant and Single Cell Analysis. United States Department of Agriculture, December 2000. http://dx.doi.org/10.32747/2000.7573082.bard.
Повний текст джерелаSharon, Amir, and Maor Bar-Peled. Identification of new glycan metabolic pathways in the fungal pathogen Botrytis cinerea and their role in fungus-plant interactions. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597916.bard.
Повний текст джерела