Добірка наукової літератури з теми "Silicon Nanochannel Membrane"

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Статті в журналах з теми "Silicon Nanochannel Membrane"

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Silvestri, Antonia, Nicola Di Trani, Giancarlo Canavese, Paolo Motto Ros, Leonardo Iannucci, Sabrina Grassini, Yu Wang, Xuewu Liu, Danilo Demarchi, and Alessandro Grattoni. "Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport." Membranes 11, no. 7 (July 15, 2021): 535. http://dx.doi.org/10.3390/membranes11070535.

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Анотація:
Manipulation of ions and molecules by external control at the nanoscale is highly relevant to biomedical applications. We report a biocompatible electrode-embedded nanofluidic channel membrane designed for electrofluidic applications such as ionic field-effect transistors for implantable drug-delivery systems. Our nanofluidic membrane includes a polysilicon electrode electrically isolated by amorphous silicon carbide (a-SiC). The nanochannel gating performance was experimentally investigated based on the current-voltage (I-V) characteristics, leakage current, and power consumption in potassium chloride (KCl) electrolyte. We observed significant modulation of ionic diffusive transport of both positively and negatively charged ions under physical confinement of nanochannels, with low power consumption. To study the physical mechanism associated with the gating performance, we performed electrochemical impedance spectroscopy. The results showed that the flat band voltage and density of states were significantly low. In light of its remarkable performance in terms of ionic modulation and low power consumption, this new biocompatible nanofluidic membrane could lead to a new class of silicon implantable nanofluidic systems for tunable drug delivery and personalized medicine.
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Pricl, Sabrina, Marco Ferrone, Paolo Cosoli, Maria Silvia Paneni, Maurizio Fermeglia, Carlo Cosentino, Francesco Amato, Mark M. C. Cheng, and Mauro Ferrari. "Release of Proteins from Nanochannel Delivery Systems: A Coupled Many-Scale Simulation - Experimental Investigation." Advances in Science and Technology 53 (October 2006): 79–84. http://dx.doi.org/10.4028/www.scientific.net/ast.53.79.

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Анотація:
Transport and surface interactions of proteins in nanopore membranes play a key role in many processes of biomedical importance. Although the use of porous materials provides a large surface-to-volume ratio, the efficiency of the operations is often determined by transport behavior, and this is complicated by the fact that transport paths (i.e., the pores) are frequently of molecular dimensions. Under these conditions, wall effects become significant, with the mobility of molecules being affected by hydrodynamic interactions between protein molecules and the wall. Modeling of transport in pores is normally carried out at the continuum level, making use of such parameters as hindrance coefficients; these in turn are typically estimated using continuum methods applied at the level of individual diffusing particles. In this work we coupled experimental evidences to manyscale molecular simulations for the analysis of hen egg-white lysozyme adsorption/diffusion through a microfabricated silicon membrane, having pores of nanometric size in only one dimension. Our joint efforts allowed us a) to elucidate the specific mechanisms of interaction between the biopolymer and the silicon surface, and b) to derive molecular energetic and structural parameters to be employed in the formulation of a mathematical model of diffusion, thus filling the gap between the nano- and the macroscale.
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Wang, Kai Ge, Peng Ye Wang, Shuang Lin Yue, Ai Zi Jin, Chang Zhi Gu, and Han Ben Niu. "Fabricating Nanofluidic Channels and Applying them for DNA Molecules Study." Solid State Phenomena 121-123 (March 2007): 777–80. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.777.

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In the emerging field of nanobiotechnology, further downsizing the fluidic channels and pores to the nanometer scale are attractive for both fundamental studies and technical applications. The insulation Silicon nitride membrane nanofluidic channel arrays which have width ~50nm and depth ~80nm and length ≥20μm were created by focused-ion-beam instrument. The λ-DNA molecules were put inside nanochannels and transferred, a fluorescence microscopy was used to observe the images. Only by capillary force, λ-DNA molecules moved inside the nanochannels which dealt with activating reagent Brij aqueous solution. These scope nanostructure devices will help us study DNA transporting through a nanopore and understand more DNA dynamics characteristics.
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Di Trani, Nicola, Antonia Silvestri, Yu Wang, Danilo Demarchi, Xuewu Liu, and Alessandro Grattoni. "Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution." Pharmaceutics 12, no. 7 (July 19, 2020): 679. http://dx.doi.org/10.3390/pharmaceutics12070679.

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Анотація:
Individualized long-term management of chronic pathologies remains an elusive goal despite recent progress in drug formulation and implantable devices. The lack of advanced systems for therapeutic administration that can be controlled and tailored based on patient needs precludes optimal management of pathologies, such as diabetes, hypertension, rheumatoid arthritis. Several triggered systems for drug delivery have been demonstrated. However, they mostly rely on continuous external stimuli, which hinder their application for long-term treatments. In this work, we investigated a silicon nanofluidic technology that incorporates a gate electrode and examined its ability to achieve reproducible control of drug release. Silicon carbide (SiC) was used to coat the membrane surface, including nanochannels, ensuring biocompatibility and chemical inertness for long-term stability for in vivo deployment. With the application of a small voltage (≤ 3 V DC) to the buried polysilicon electrode, we showed in vitro repeatable modulation of membrane permeability of two model analytes—methotrexate and quantum dots. Methotrexate is a first-line therapeutic approach for rheumatoid arthritis; quantum dots represent multi-functional nanoparticles with broad applicability from bio-labeling to targeted drug delivery. Importantly, SiC coating demonstrated optimal properties as a gate dielectric, which rendered our membrane relevant for multiple applications beyond drug delivery, such as lab on a chip and micro total analysis systems (µTAS).
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Pricl, Sabrina, Marco Ferrone, Maurizio Fermeglia, Francesco Amato, Carlo Cosentino, Mark Ming-Cheng Cheng, Robert Walczak, and Mauro Ferrari. "Multiscale modeling of protein transport in silicon membrane nanochannels. Part 1. Derivation of molecular parameters from computer simulations." Biomedical Microdevices 8, no. 4 (September 25, 2006): 277–90. http://dx.doi.org/10.1007/s10544-006-0031-2.

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Amato, Francesco, Carlo Cosentino, Sabrina Pricl, Marco Ferrone, Maurizio Fermeglia, Mark Ming-Cheng Cheng, Robert Walczak, and Mauro Ferrari. "Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model." Biomedical Microdevices 8, no. 4 (September 25, 2006): 291–98. http://dx.doi.org/10.1007/s10544-006-0032-1.

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Qiang, Rongrong, ChenJie Wei, Ligang Lin, Xuesong Deng, Tiantian Zheng, Qi Wang, Yixin Gao, and Yuzhong Zhang. "Bioinspired: A 3D vertical silicon sponge-inspired construction of organic-inorganic loose mass transfer nanochannels for enhancing properties of polyimide nanofiltration membranes." Separation and Purification Technology 259 (March 2021): 118038. http://dx.doi.org/10.1016/j.seppur.2020.118038.

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Kim, Sungsoon, Minwoo Lee, Sangjin Choi, Jongbum Won, Taehoon Kim, Taeyoung Kim, Jihong Bae, and Wooyoung Shim. "Cation-selective layered silicon oxide membranes for power generation." Journal of Physics: Energy, December 2, 2022. http://dx.doi.org/10.1088/2515-7655/aca829.

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Анотація:
Abstract Inorganic two-dimensional membranes offer a new approach to modulating mass transport at the nanoscale. These membranes, which can harness the van der Waals gap as a nanochannel and address persistent challenges in organic membranes, are limited to a few material libraries such as graphene, graphene oxide, molybdenum disulfide, and boron nitride. Here we report for the first time the development of cation-selective layered silicon oxide membranes, in which the nanochennels, specifically the van der Waals gap, can allow cation diffusion flux to generate an electromotive force for a long time. Considering the abundance and well-known properties of silicon oxide, this inorganic membrane can provide a promising route for membrane separation in variety of applications.
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Mariazzi, S., B. Rienäcker, R. Magrin Maffei, L. Povolo, S. Sharma, R. Caravita, L. Penasa, P. Bettotti, M. Doser, and R. S. Brusa. "Forward emission of positronium from nanochanneled silicon membranes." Physical Review B 105, no. 11 (March 22, 2022). http://dx.doi.org/10.1103/physrevb.105.115422.

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Тези доповідей конференцій з теми "Silicon Nanochannel Membrane"

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Grattoni, Alessandro, Xuewu Liu, Zongxing Wang, Jaskaran Gill, Arturas Ziemys, and Mauro Ferrari. "Electrokinetic Transport of Molecules Through Nanochanneled Membranes." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13236.

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Анотація:
Our research group was the first one to microfabricate and demonstrate nano-channels in silicon membranes (1, 2). We employed nano-channeled chips to provide immuno-isolation for cell transplantation towards the treatment of diabetes (3), for biomolecular separation (4), and for the controlled passive and active release of drug molecules from implanted capsules (5). We showed that the constraints placed upon molecular agitation in nano-channels affected their concentration-driven transport kinetics (6, 7). A zero-order passive release of biological molecules was achieved, by the rational tailoring of nano-channels dimensions. This achievement allowed releasing of a constant amount of drugs over a long period of time. However, the development and optimization of many drug therapies require long-term drug delivery with controlled but variable dosage using miniaturized systems (8). Moreover, application such as drug release from implanted devices requires tight operational control, of regulatory agency caliber. We have engaged in the development and characterization of elecroosmotic nano-channels membranes, and present our results in this communication. These include the influence of the drug release rate on nanochannel size, membrane configuration, and applied voltage.
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Rosengarten, Gary. "Can We Learn From Nature to Design Membranes? The Intricate Pore Structure of the Diatom." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82148.

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Анотація:
Membranes are ubiquitous functional elements used in separation processes. An ideal membrane will stop certain species penetrating it while having excellent transport properties for others. Membranes are used in synthetic systems such as fuel cells and desalination plants, but are also formed naturally in biological systems. For example all cells use a membrane to contain the cellular contents, while allowing transport of nutrients though the cell wall. I will present our recent work on examining diatoms, which are unicellular algae that grow in water. They have a self assembled silica membrane wall with a regular array of nanopores whose function is very poorly understood. I will outline the unique structure of the pores and our experimental work on understanding their structure to help develop membranes with better performance.
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Gill, Jaskaran Singh, Alessandro Grattoni, Arturas Ziemys, and Mauro Ferrari. "Characterzation and Quality Control for Micro- and Nanochanneled Silicon Membranes." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13297.

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Анотація:
The rapid advancement of silicon fabrication techniques has enabled the production of large numbers of precisely designed devices. Such devices are appealing to a wide range of industries and have already seen use in energy conversion [1] and medical applications [2]. Our group’s interest is in the latter; specifically the use of micro- and nanofabricated channels in silicon for the controlled release of drugs.
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Kim, Dong-Kwon, Chuanhua Duan, Yu-Feng Chen, and Arun Majumdar. "Power Generation From Concentration Gradient by Reverse Electrodialysis in Ion Selective Nanochannel." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82208.

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Анотація:
In this article, ion selective nanochannels are studied to generate electric power from concentration gradient by reverse electrodialysis. When nanochannels bring into contact with aqueous solution, the surface of nanochannels acquires charges from ionization, ion adsorption, and ion dissolution. These surface charges draw counter-ions toward the surface and repel co-ions away. Therefore, when an electrolyte concentration gradient is applied to nanochannels, counter-ions are transported through nanochannels much more easily than co-ions, which results in a net charge migration of ions. Gibbs free energy of mixing, which forces ion diffusion, thus can be converted into electrical energy by using ion-selective nanochannels. Silica nanochannels with heights of 26 nm and 80 nm fabricated by glass-silicon anodic bonding were used in this study. We experimentally investigated the power generation from these nanochannels placed between two potassium chloride solutions with various combinations of concentrations. The power generation per unit channel volume increases when the concentration gradient increases, while it decreases as channel height decreases. The highest power density measured is 26 kW/m3. Our data also indicates that the efficiency of energy conversion and the ion selectivity increase with a decrease of concentrations and channel height. The best efficiency obtained is 24%. Compared with ion-selective membranes, nanochannels promise more reliable operation since they are readily compatible with standard CMOS process and do not shrink and swell in response to their environment. Power generation from concentration gradient in ion selective nanochannels could be used in a variety of applications, including micro batteries and micro power generators.
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Burgin, Tucker, Dean Johnson, Henry Chung, Alfred Clark, and James McGrath. "Ultrathin Silicon Membranes for Improving Extracorporeal Blood Therapies." In ASME 2016 14th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2016 Heat Transfer Summer Conference and the ASME 2016 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/icnmm2016-8052.

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Анотація:
Extracorporeal blood therapies such as hemodialysis and extracorporeal membrane oxygenation supplement or replace organ function by the exchange of molecules between blood and another fluid across a semi-permeable membrane. Traditionally, these membranes are made of polymers with large surface areas and thicknesses on the scale of microns. Therapeutic gas exchange or toxin clearance in these devices occurs predominantly by diffusion, a process that is described by an inverse square law relating a distance to the average time a diffusing particle requires to travel that distance. As such, small changes in membrane thickness or other device dimensions can have significant effects on device performance — and large changes can cause dramatic paradigm shifts. In this work, we discuss the application of ultrathin nanoporous silicon membranes (nanomembranes) with thicknesses on the scale of tens of nanometers to diffusion-mediated medical devices. We discuss the theoretical consequences of nanomembrane medical devices for patients, analyzing several notable benefits such as reduced device size (enabling wearability, for instance) and improved clearance specificity. Special attention is paid to computational and analytical models that describe real experimental behavior, and that in doing so provide insights into the relevant parameters governing the devices.
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David, Milnes P., Amy Marconnet, and Kenneth E. Goodson. "Hydrodynamic and Thermal Performance of a Vapor-Venting Microchannel Copper Heat Exchanger." In ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62269.

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Анотація:
Two-phase microfluidic cooling has the potential to achieve low thermal resistances with relatively small pumping power requirements compared to single-phase heat exchanger technology. Two-phase cooling systems face practical challenges however, due to the instabilities, large pressure drop, and dry-out potential associated with the vapor phase. Our past work demonstrated that a novel vapor-venting membrane attached to a silicon microchannel heat exchanger can reduce the pressure drop for two-phase convection. This work develops two different types of vapor-venting copper heat exchangers with integrated hydrophobic PTFE membranes and attached thermocouples to quantify the thermal resistance and pressure-drop improvement over a non-venting control. The first type of heat exchanger, consisting of a PTFE phase separation membrane and a 170 micron thick carbon-fiber support membrane, shows no improvement in the thermal resistance and pressure drop. The results suggest that condensation and leakage into the carbon-fiber membrane suppresses venting and results in poor device performance. The second type of heat exchanger, which evacuates any liquid water on the vapor side of the PTFE membrane using 200 ml/min of air, reduces the thermal resistance by almost 35% in the single-phase regime in comparison. This work shows that water management, mechanical and surface properties of the membrane as well as its attachment and support within the heat exchanger are all key elements of the design of vapor-venting heat exchangers.
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Hagino, Harutoshi, and Koji Miyazaki. "Thermal Transport Property of Silicon Membranes With Asymmetric Porous Structure." In ASME 2015 13th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2015 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/icnmm2015-48281.

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Анотація:
The size effect on thermal conduction due to phonon boundary scattering in films was studied as controlling heat conduction. Thermal rectifier was proposed as a new heat control concept by a ballistic rectifier relies on asymmetric scattering of phonons in asymmetric linear structure. We focus on the thermal rectification effect in membrane with asymmetric pores. We discussed on the thermal rectification effect from the calculation and thermal conductivity measurement of asymmetric structured membrane. Thermal conduction was calculated by using radiation calculation of ANSYS Fluent based on Boltzmann transport theory which is development of equation of phonon radiative transfer from view point of phonon mean free path and boundary scattering condition. In-plane thermal conductivities of free standing membranes with microsized asymmetric pores were measured by periodic laser heating measurement. From the result of calculation, phonons were transition to ballistic transport in the membranes with asymmetric shaped pores and thermal rectification effect was obtained on the condition of specular scattering because of the asymmetric back-scattering of ballistic phonons from asymmetric structure. The thermal rectification effect was increased with decreasing thickness of membrane shorter and shorter than mean free path of phonon. From the result of measurements, we were able to confirm the reduction of thermal conductivity based on ballistic phonon transport theory, but the strong thermal rectification effect was not confirmed.
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Titovskaya, Yana V., Natalya L. Shwartz, Sergey I. Romanov, and Zoya Sh Yanovitskaja. "Monte Carlo simulation of MBE and oxidation of porous silicon surface for production nanochannel membranes." In 2009 International Conference and Seminar on Micro/Nanotechnologies and Electron Devices (EDM). IEEE, 2009. http://dx.doi.org/10.1109/edm.2009.5173930.

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Smith, Karl J. P., Joshua Winans, and James McGrath. "Ultrathin Membrane Fouling Mechanism Transitions in Dead-End Filtration of Protein." In ASME 2016 14th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2016 Heat Transfer Summer Conference and the ASME 2016 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/icnmm2016-7989.

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Анотація:
Ultrathin membranes will likely see great utility in future membrane-based separations, but key aspects of the performance of these membranes, especially when they are used to filter protein, remain poorly understood. In this work we perform protein filtrations using new nanoporous silicon nitride (NPN) membranes. Several concentrations of protein are filtered using dead end filtration in a benchtop centrifuge, and we track fouling based on the amount of filtrate passed over time. A modification of the classic fouling model that includes the effects of using a centrifuge and allow for the visualization of a transition between pore constriction and cake filtration demonstrate that for a range of protein concentrations, cake filtration supersedes pore constriction after ∼30 seconds at 690 g.
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Kolb, Gunther, Peter Detemple, Daniel Latta, Stefan Schmitt, Yong Men, and Ralf Zapf. "A Novel and Miniaturised Thin Film Pellistor for Carbon Monoxide Detection in Hot Gas Flows." In ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2006. http://dx.doi.org/10.1115/icnmm2006-96233.

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Анотація:
A thin film pellistor is under development at IMM for the selective detection of carbon monoxide in hot gas flows. The selective methanation reaction of carbon monoxide to methane is applied to generate chemical heat of reaction, which is then detected by direct measurement of thermal conductivity. The chemical reaction is performed over a nickel/calcium oxide/alumina catalyst, which is directly deposited onto a silicon nitride membrane being part of the sensor.
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