Дисертації з теми "Signaling lipid"
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Benarab, Ammar. "Harnessing endothelial lipid signaling for ischemic stroke protection." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5197.
Повний текст джерелаRationale: Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular functions in other organs and S1P1 (S1P receptor-1) modulators including fingolimod show promise for the treatment of ischemic and hemorrhagic stroke. However, S1P1 also coordinates lymphocyte trafficking, and lymphocytes are currently viewed as the principal therapeutic target for S1P1 modulation in stroke. Objective: To address roles and mechanisms of engagement of endothelial cell S1P1 in the naive and ischemic brain and its potential as a target for cerebrovascular therapy. Methods and results: Using spatial modulation of S1P provision and signaling, we demonstrate a critical vascular protective role for endothelial S1P1 in the mouse brain. With an S1P1 signaling reporter, we reveal that abluminal polarization shields S1P1 from circulating endogenous and synthetic ligands after maturation of the blood-neural barrier, restricting homeostatic signaling to a subset of arteriolar endothelial cells. S1P1 signaling sustains hallmark endothelial functions in the naive brain and expands during ischemia by engagement of cell-autonomous S1P provision. Disrupting this pathway by an endothelial cell-selective deficiency in S1P production, export, or the S1P1 receptor substantially exacerbates brain injury in permanent and transient models of ischemic stroke. By contrast, profound lymphopenia induced by loss of lymphocyte S1P1 provides modest protection only in the context of reperfusion. In the ischemic brain, endothelial cell S1P1 supports blood-brain barrier function, microvascular patency, and the rerouting of blood to hypoperfused brain tissue through collateral anastomoses. Boosting these functions by supplemental pharmacological engagement of the endothelial receptor pool with a blood-brain barrier penetrating S1P1-selective agonist can further reduce cortical infarct expansion in a therapeutically relevant time frame and independent of reperfusion. Conclusions: This study provides genetic evidence to support a pivotal role for the endothelium in maintaining perfusion and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be harnessed for neuroprotection with blood-brain barrier-penetrating S1P1 agonists
Cheong, Fei Ying. "Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-71011.
Повний текст джерелаHerman, Moreno Maria Dolores. "Structural studies of proteins in apoptosis and lipid signaling." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8212.
Повний текст джерелаAivazian, Dikran A. (Dikran Arvid) 1971. "Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8583.
Повний текст джерелаVita.
Includes bibliographical references (leaves 116-131).
Protein-lipid interactions are emerging as key components of cellular processes such as protein and membrane trafficking and cell-cell signaling. Many proteins bind lipid reversibly, including cytoplasmic proteins involved in signal transduction, such as Ras and Src. Membrane binding is vital for the function of these signaling proteins both through co-localization with other signaling proteins as well as effects of lipid on intrinsic activities. In this thesis, protein-lipid interactions of subunits of key antigen recognition receptors of the immune system are investigated. The proteins studied are the cytoplasmic domains of immunoreceptor signaling subunits that mediate transmembrane signal transduction in response to receptor engagement. The cytoplasmic domains derive from the T cell receptor, the B cell receptor, Fe receptors and Natural Killer cell stimulatory receptors. The TCR, CD3, CD3, CD3, ... and DAP12 cytoplasmic domains all bind lipid, whereas those of B cell receptor Iga and Igp do not. While all of these proteins are unstructured in solution, ... and CD3 undergo extensive increases in secondary structure upon lipid binding. Lipid binding of ... is found to inhibit its accessibility to kinase-mediated phosphorylation. Based on these results it is proposed that interactions with lipid may regulate the function of receptor cytoplasmic domains, as with many cytosolic proteins involved in signaling processes.
by Dikran A. Aivazian.
Ph.D.
Secor, Jordan Douglas. "Phytochemical Antioxidants Induce Membrane Lipid Signaling in Vascular Endothelial Cells." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338391553.
Повний текст джерелаCody, West Kime. "Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program." Kyoto University, 2018. http://hdl.handle.net/2433/232302.
Повний текст джерелаKline, Michelle A. "Membrane cholesterol regulates vascular endothelial cell viability, function, and lipid signaling." Connect to resource, 2008. http://hdl.handle.net/1811/32175.
Повний текст джерелаSadhukhan, Sushabhan. "Metabolism & Signaling of 4-Hydroxyacids: Novel Metabolic Pathways and Insight into the Signaling of Lipid Peroxidation Products." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339171892.
Повний текст джерелаKilaru, Aruna. "Discovery of Anandamide, a Novel Lipid Signaling Molecule in Moss and Its Implications." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/4771.
Повний текст джерелаHerrera-Velit, Patricia. "Bacterial lipopolysaccharides signaling pathways in mononuclear phagocytes involve protein and lipid kinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0034/NQ27161.pdf.
Повний текст джерелаXia, Ye. "THE ROLE OF CUTICLE, FATTY ACIDS, AND LIPID SIGNALING IN PLANT DEFENSE." UKnowledge, 2010. http://uknowledge.uky.edu/plantpath_etds/10.
Повний текст джерелаYecies, Jessica. "SREBP: A Key Effector of mTORC1 Signaling in Metabolism and Cancer." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10023.
Повний текст джерелаUnnerståle, Sofia. "NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer." Licentiate thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-59534.
Повний текст джерелаMok, Crystal Yin Lam. "The role of lipid accumulation and insulin signaling in adipose tissue macrophage polarization." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648349.
Повний текст джерелаRapovy, Shannon Marie. "Characterization of the Physico-chemical Properties of the Novel Signaling Lipid Diacylglycerol Pyrophosphate." Kent State University Honors College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335810423.
Повний текст джерелаCheong, Fei Ying [Verfasser], and Peter PD [Akademischer Betreuer] Mayinger. "Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1 / Fei Ying Cheong ; Betreuer: Peter PD Mayinger." Heidelberg : Universitätsbibliothek Heidelberg, 2007. http://d-nb.info/1178796647/34.
Повний текст джерелаGyllberg, Hanna. "Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7115.
Повний текст джерелаRimmerman, Neta. "The signaling properties in sensory neurons of the novel endogenous lipid N-palmitoyl glycine." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3283743.
Повний текст джерелаSource: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6514. Adviser: J. Michael Walker. Title from dissertation home page (viewed May 21, 2008).
Chapagai, Danda P. "Biochemical Characterization of SBIP-470 and its role in SA-mediated Signaling in Plants." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2428.
Повний текст джерелаBERTOLIO, REBECCA. "Sterol Regulatory Element Binding Protein couples mechanical cues to lipid metabolism." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2963753.
Повний текст джерелаOakley, Fredrick Daniel. "Biology of redox active endosomal signaling in response to Il-1-Beta." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1045.
Повний текст джерелаSearcy, James Lucas. "LIPID SIGNALING IN BRAIN AGING AND ALZHEIMER'S DISEASE: PHARMACOLOGICALLY TARGETING CHOLESTEROL SYNTHESIS, TRANSPORT AND METABOLISM." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1147.
Повний текст джерелаTitle from document title page (viewed on May 12, 2010). Document formatted into pages; contains: xiv, 183 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 158-177).
Shrivastava, Shamit. "Non-linear solitary sound waves in lipid membranes and their possible role in biological signaling." Thesis, Boston University, 2014. https://hdl.handle.net/2144/11049.
Повний текст джерелаBiological macromolecules self-assemble under entropic forces to form a dynamic 20 interfacial medium where the elastic properties arise from the curvature of the entropic potential of the interface. Elastic interfaces should be capable of propagating localized perturbations analogous to sound waves. However, (1) the existence and (2) the possible role of such waves in affecting biological functions remain unexplored. Both these aspects of "sound' as a signaling mechanism in biology are explored experimentally on mixed monolayers of lipids-fluorophores-proteins at the air/water interface as a model biological interface. This study shows - for the first time - that the nonlinear susceptibility near a thermodynamic transition in a lipid monolayer results in nonlinear solitary sound waves that are of 'all or none ' nature. The state dependence of the nonlinear propagation is characterized by studying the velocity-amplitude relationship and results on distance dependence, effect of geometry and collision of solitary waves are presented. Given that the lipid bilayers and real biological membranes have such nonlinearities in their susceptibility diagrams, similar solitary phenomenon should be expected in biological membranes. In fact the observed characteristics of solitary sound waves such as, their all or none nature, a biphasic pulse shape with a long tail and optp-mechano-electro-thermal coupling etc. are strikingly similar to the phenomenon of nerve pulse propagation as observed in single nerve fibers. Finally given the strong correlation between the activity of membrane bound enzymes and the susceptibility and the fact that the later varies within a single solitary pulse, a new thermodynamic basis for biological signaling is proposed. The state of the interface controls both the nature of sound propagation and its impact on incorporated enzymes and proteins. The proof of concept is demonstrated for acetylcholine esterase embedded in a lipid monolayer, where the enzyme is spatiotemporally "knocked out" by a propagating sound wave.
Andrews, Shantaya Biunca, Timothy Audam, and Dhirendra Dr Kumar. "Characterization of SIP470, A Plant Lipid Transfer Protein, and its Role in Plant Defense Signaling." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/44.
Повний текст джерелаCinque, A. "PLEIOTROPIC EFFECTS OF PERIFOSINE ON GLIOBLASTOMA CELLS SURVIVAL: ALTERED MEMBRANE LIPID METABOLISM AND CELL SIGNALING." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/364862.
Повний текст джерелаHoman, Edwin. "Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10343.
Повний текст джерелаChemistry and Chemical Biology
Filho, Edismauro Garcia Freitas. "O papel de gangliosídeos específicos como moduladores da liberação de mediadores de mastócitos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-21052015-180820/.
Повний текст джерелаMast cells are immunoregulatory cells that participate in diverse biological events. The action of mast cells is directly related to their activation and subsequent mediator release. Early signal transduction events occur in lipid rafts in the plasma membrane. GD1b-derived gangliosides are known constituents of lipid rafts in rodent mast cells. The cross-linking of these gangliosides by mAb AA4 results in a partial activation of mast cells similar to that observed when FcRIs are cross-linked, but does not result in the mast cell degranulation. With time, the gangliosides bound to mAb AA4 cap on the cell surface. The present study aims to characterize the role of the rodent mast cell specific gangliosides derived from GD1b in mediator release from RBL-2H3 mast cells. Cross-linking the GD1b-derived gangliosides activated the transcription factors NFAT and NFB and this activation was mediated by Syk. The activation of theses transcription factors by cross-linked GD1b-derived gangliosides results in the release of the neo-synthesized mediators TNF- and interleukin (IL)-4. However, cross-linking GD1b-derived gangliosides did not stimulate release of the newly formed mediators leukotriene B4 (LTB4) and leukotriene C4 (LTC4). Capping of GD1b-derived gangliosides disorganized lipid rafts and resulted in a redistribution of lipid raft components. Proteomic analysis showed that proteins that trigger mast cell activation and negative regulatory proteins of degranulation are up regulated, whereas proteins critical for signal transduction are down regulated in mast cells where the gangliosides are capped. The results of this work demonstrate that the mast cell-specific GD1b-derived gangliosides are crucial in maintaining the functional integrity of the lipid rafts and modulate cell activation and subsequent mediator release from mast cells.
Dian, Emese Emöke. "Application of Cultured Neuronal Networks for Use as Biological Sensors in Water Toxicology and Lipid Signaling." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc5557/.
Повний текст джерелаAudam, Timothy Ndagi. "Characterization of SIP470, a Family 1 Lipid Transfer Protein and its Role in Plant Stress Signaling." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3103.
Повний текст джерелаDesbourdes, Céline. "Nucléoside diphosphate kinase D : une protéine mitochondriale bifonctionnelle." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV004/document.
Повний текст джерелаThe nucleoside diphosphate kinases (NDPK) are essential for generation of nucleoside triphosphates (NTPs) using ATP and NDPs. The mitochondrial NDPK isoform (NDPK-D) located in the mitochondrial intermembrane space is found to have two modes of function. First, the phosphotransfer mode in which the protein has a kinase activity like other NDPK enzymes. In this mode, NDPK-D produces GTP for the optic atrophy 1 protein (OPA1), a GTPase involved in mitochondrial fusion, and ADP for the adenylate translocator (ANT) and the mitochondrial ATPase for ATP regeneration. The second mode of function is called lipid transfer and is related to the capacity of NDPK-D to bind anionic phospholipids, especially cardiolipin (CL). In this mode, the protein can cross-link the two mitochondrial membranes and transfer CL from the inner to the outer mitochondrial membrane, which can serve as a signal for mitophagy and apoptosis. This work aims to study these NDPK-D functions in more detail. With the use of HeLa cells stably expressing the wild-type, kinase inactive (H151N mutation) or lipid binding deficient (R90D mutation) NDPK-D and mouse lung epithelial cells, we show (i) the close proximity between NDPK-D and OPA1 that leads to GTP channeling from NDPK-D to OPA1, (ii) the essential role of NDPK-D for CL externalization to the mitochondrial surface during mitophagy, serving as a recognition signal for LC3-II-autophagosomes to eliminate damaged mitochondria, (iii) the possible inhibition of CL externalization due to the presence of NDPK-D/OPA1 complexes, and (iv) a pro-metastatic phenotype of HeLa cells expressing either of the NDPK-D mutants (H151N or R90D), characterized by high invasive and migratory potential, altered proteomic profile and changed mitochondrial network structure and function. Finally, a first bacterial expression and purification strategy for full-length OPA1 has been established for future in vitro studies of NDPK-D/OPA1 complexes
Kwong, Eric K. "The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5808.
Повний текст джерелаMahammad, Saleemulla. "Cholesterol in T cells homeostasis, plasma membrane organization and signaling /." Doctoral thesis, Stockholm : The Wenner-Gren Institute, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38357.
Повний текст джерелаAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: In press.
Goswami, Ishan. "Computational and Experimental Investigation of the Critical Behavior Observed in Cell Signaling Related to Electrically Perturbed Lipid Systems." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97564.
Повний текст джерелаPh. D.
Panakova, Daniela. "Lipoprotein particles associate with lipid-linked proteins and are required for long-range Wingless and Hedgehog signaling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1122025765300-27455.
Повний текст джерелаKlose, Jana. "The role of lipid signaling and metabolism in morphogenesis and pathogenesis of the fungal pathogen Ustilago maydis." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31085.
Повний текст джерелаScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Efe, Jem A. "Vacuole biogenesis, function, and size control in S. cerevisiae central roles for membrane trafficking and lipid signaling /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3292284.
Повний текст джерелаTitle from first page of PDF file (viewed October 8, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 166-184).
Krothapalli, Kartikeya. "Association of plastid lipid metabolism with the activation of systemic acquired resistance in Arabidopsis thaliana." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1058.
Повний текст джерелаNewton, Hannah S. "Potassium channels and adenosine signaling in T cells of head and neck cancer patients." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1603713656776019.
Повний текст джерелаMandal, Mihir Kumar. "MOLECULAR AND BIOCHEMICAL CHARACTERIZATION OF OLEATE- AND GLYCEROL-3-PHOSPHATE-REGULATED SIGNALING IN PLANTS." UKnowledge, 2012. http://uknowledge.uky.edu/plantpath_etds/3.
Повний текст джерелаPaquette, Sara Montminy. "Evasion of LPS-TLR4 Signaling as a Virulence Determinate for Yersinia pestis." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/458.
Повний текст джерелаHodson, Jane E. "Tobacco Phospholipase D β1: Molecular Cloning and Biochemical Characterization". Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3341/.
Повний текст джерелаBuscató, Arsequell Estel·la [Verfasser], Ewgenij [Akademischer Betreuer] Proschak, and Dieter [Akademischer Betreuer] Steinhilber. "Synthesis and in vitro evaluation of lipid signaling modulators / Estella Buscató Arsequell. Gutachter: Dieter Steinhilber ; Ewgenij Proschak. Betreuer: Ewgenij Proschak." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2013. http://d-nb.info/1046622684/34.
Повний текст джерелаMahon, Robert Norman III. "Direct Inhibition of CD4+ T-cell Activation by Mycobacterium tuberculosis Cell Wall Glycolipids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275668686.
Повний текст джерелаYu, Lingli. "Nerve Growth Factor Signaling from Membrane Microdomain to Nucleus : Differential Regulation by Caveolins." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00796393.
Повний текст джерелаWehmeyer, Lance. "Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11346.
Повний текст джерелаIncludes bibliographical references (leaves 121-158).
A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for the effects of stress on reproduction. The present study investigated whether this crosstalk between the GR and GnRHR involves the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciprocally modulate each other’s signaling pathways.
Gorjão, Renata. "Efeito dos ácidos graxos sobre a via de sinalização da interleucina-2 em linfócitos humanos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-15092008-134403/.
Повний текст джерелаThe effect of fatty acids (FA) on interleukin -2 (IL-2) signaling pathway in human lymphocytes was investigated. Docosahexaenoic (DHA), eicosapentaenoic (EPA), palmitic (PA) and stearic (SA) acids decreased lymphocyte proliferation in concentrations above 50 mM. However, oleic (OA) and linoleic (LA) acids increase lymphocyte proliferation at 25 mM. PA, SA, DHA and EPA decreased JAK 1, JAK 3, STAT 5 and AKT phosphorylation induced by IL-2 but OA and LA did not cause any effect. OA and LA increased ERK1/2 phosphorylation whereas the other FA caused a marked decrease. PKC-Z phosphorylation was decreased by OA and LA only. In conclusion, the inhibitory effect of PA, SA, DHA and EPA on lymphocyte proliferation observed in our previous study was due to a decrease in protein phosphorylation activated by IL-2. Probably, OA and LA stimulated lymphocyte proliferation by increasing ERK 1/2 phosphorylation throught PKC-Z activation. The inhibition of JAK 1, JAK3, STAT 5, ERK1/2 and Akt phosphorylation caused by DHA is associated to a decrease in membrane lipid rafts contend.
Paulino, Rachel Santini. "Estresse oxidativo de duas espécies de macrófitas aquáticas em diferentes condições ambientais em um estuário de região neotropical." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153368.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O estresse oxidativo causado pela produção de espécies reativas de oxigênio (EROs) é uma das respostas que as plantas apresentam frente a um estresse ambiental. Nosso objetivo foi avaliar o estresse oxidativo das macrófitas aquáticas Crinum americanum e Spartina alterniflora em duas condições: salinidade e nutrientes que ocorrem no estuário do rio Itanhaém (SP). Raízes e folhas (5 plantas) de C. americanum foram coletadas em cada área (5 amostras/área). O material vegetal para análises de clorofila (a+b), carotenóides, peróxido de hidrogênio (H2O2), malonaldeído (MDA) e enzimas antioxidantes SOD e CAT foram acondicionado em N2 líquido no campo e posteriormente armazenado em freezer a -80 °C. Também foram coletados em cada réplica material vegetal para avaliar o teor de N e P totais da planta e do sedimento Os dados obtidos foram submetidos à Análise de Variância (ANOVA) e comparados pelo teste de Tukey (p < 0,05). Os resultados obtidos mostraram que: C. americanum e S. alterniflora sofreram maior estresse oxidativo em alto e médio estuário, respectivamente; Os indivíduos de S. alterniflora sofreram maior estresse na área de lançamento de esgoto.
The oxidative stress caused by the production of reactive oxygen species (ROS) is one of the responses that plants exhibit facing environmental stress. Our objective was to evaluate the oxidative stress of the aquatic macrophytes Crinum americanum and Spartina alterniflora under two conditions: salinity and nutrients that occur in the estuary of the Itanhaém river (SP). Roots and leaves (5 plants) of C. americanum were collected in each area (5 samples / area). The plant material for analysis of chlorophyll (a + b), carotenoids, H2O2, MDA and antioxidant enzymes SOD and CAT with platform in N2 without field and liquid in freezer at -80 ° C. Vegetable material was also collected in each replicate to evaluate the total N and P content of the plant and of the sediment. The data were submitted to Analysis of Variance (ANOVA) and compared by the Tukey test (p <0.05). The results showed that: C. americanum and S. alterniflora suffered higher oxidative stress in upper and middle estuary, respectively; The State of São Paulo changes have suffered greater stress in the area of sewage
2018SLR05032
Lajoie, Patrick. "Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/336.
Повний текст джерелаTiwari, Vijay. "Isolation and Heterologous Expression of Putative Tomato Fatty Acid Amide Hydrolase." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3138.
Повний текст джерелаGatbonton-Schwager, Tonibelle N. "Biological and Chemical Analysis of Small Molecule Activators of Anti-inflammatory and Antioxidant Nrf2-Keap1 Signaling." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1390560628.
Повний текст джерела