Дисертації з теми "Sign selector"

Pour différentes raisons, la 5G domine actuellement l'actualité technologique. Les capacités de la 5G en termes de largeur de bande et de temps réel constitues un énorme potentiel sociétal en permettant pléthore d'applications nouvelles et inattendues. En effet, la bande de fréquence des ondes millimétriques se caractérise par une largeur de bande disponible qui peut prendre en charge des systèmes sans fil à haut débit pour les futurs systèmes de radiocommunication, y compris les systèmes cellulaires de cinquième génération et au-delà. Les fréquences d'exploitation des ondes millimétriques nécessitent généralement une plus grande ouverture d'antenne pour améliorer le bilan de liaison. Ces antennes se présentent généralement sous la forme de réseaux phasés, permettant la formation de faisceaux. Dans ce contexte, ce travail présente la conception et la mise en œuvre d'un déphaseur actif à 19,5 GHz pour la formation de faisceaux. Le circuit proposé est basé sur une architecture originale utilisant un oscillateur commandé en tension verrouillé par injection (ILVCO en Anglais) associé à un filtre polyphase suivi d'un circuit de sélection de phase et de son signe. La phase souhaitée dans la plage de ± 45° est synthétisée avec le circuit proposé en modifiant la tension de commande Vcntr de l’ILVCO pour un réglage fin et en modifiant les deux signaux de commandes du sélecteur de phase et de signe (S0, S2) pour un réglage grossier, ce qui engendre une variation de phase linéaire de 360°. D'après les résultats de la simulation post-layout, la plage de réglage de la fréquence d’oscillation libre du VCO varie de 17,89 GHz à 20,16 GHz. En outre, avec une puissance injectée de -8,5 dBm et une fréquence de 19,5 GHz, le déphaseur proposé consomme 20,47 mA sous une tension d'alimentation de 1,3 V. De plus, la puissance de sortie moyenne sur 50 Ω est de -15,58 dBm. Le circuit complet a une taille de 1,58 mm2, y compris les pads, et il est intégré sur un process BiCMOS SiGe:C 0,13 μm. Enfin, les résultats obtenus montrent que le déphaseur actif proposé s’avère un candidat potentiel pour les systèmes à réseau phasé utilisés pour la formation de faisceaux dans les applications 5G
For good reasons, 5G dominates technological news. The high-bandwidth and real-time capabilities of 5G have huge societal potential by enabling a plethora of new and unanticipated application cases. Indeed, the millimeter-wave frequency band is characterized by an available bandwidth that can support high-speed wireless systems for future radio communications systems, including 5th Generation cellular systems and beyond. The frequencies of operation at mm-wave generally requires larger antenna aperture to improve the channel budget at useful distances. These antennas are usually in the form of phased arrays, allowing beamforming to be performed. This work presents the design and implementation of a 19.5 GHz active phase shifter for beamforming in 5G applications. The proposed circuit is based on an original architecture using an injection-locked voltage-controlled oscillator (ILVCO) associated with a polyphase filter followed by a phase selection circuit and its sign. The desired phase in the range of ± 45° is synthesised with the proposed circuit by altering the control voltage Vcntr of an ILVCO for fine-tuning and modifying the two control signals of phase and sign selectors (S0, S2) for coarse tuning, resulting in a 360° linear phase variation. According to the post-layout simulation results, the frequency tuning range of the VCO varies from 17.89 GHz to 20.16 GHz in free-running mode. In addition, with an injected power of -8.5 dBm and a frequency of 19.5 GHz, the proposed phase shifter draws 20.47 mA from a 1.3 V supply voltage. Furthermore, the mean output power on 50 Ω load is found to be -15.58 dBm. The whole circuit has a chip size of 1.58 mm2 including the pads and it is integrated in a BiCMOS SiGe:C 0.13 μm process. Finally, the obtained results justify that the proposed active phase shifter is a relevant design for phased-array systems used for beamforming in 5G applications

This dissertation presents segmental discriminative analysis techniques for American Sign Language (ASL) recognition and verification. ASL recognition is a sequence classification problem. One of the most successful techniques for recognizing ASL is the hidden Markov model (HMM) and its variants. This dissertation addresses two problems in sign recognition by HMMs. The first is discriminative feature selection for temporally-correlated data. Temporal correlation in sequences often causes difficulties in feature selection. To mitigate this problem, this dissertation proposes segmentally-boosted HMMs (SBHMMs), which construct the state-optimized features in a segmental and discriminative manner. The second problem is the decomposition of ASL signs for efficient and accurate recognition. For this problem, this dissertation proposes discriminative state-space clustering (DISC), a data-driven method of automatically extracting sub-sign units by state-tying from the results of feature selection. DISC and SBHMMs can jointly search for discriminative feature sets and representation units of ASL recognition. ASL verification, which determines whether an input signing sequence matches a pre-defined phrase, shares similarities with ASL recognition, but it has more prior knowledge and a higher expectation of accuracy. Therefore, ASL verification requires additional discriminative analysis not only in utilizing prior knowledge but also in actively selecting a set of phrases that have a high expectation of verification accuracy in the service of improving the experience of users. This dissertation describes ASL verification using CopyCat, an ASL game that helps deaf children acquire language abilities at an early age. It then presents the "probe" technique which automatically searches for an optimal threshold for verification using prior knowledge and BIG, a bi-gram error-ranking predictor which efficiently selects/creates phrases that, based on the previous performance of existing verification systems, should have high verification accuracy. This work demonstrates the utility of the described technologies in a series of experiments. SBHMMs are validated in ASL phrase recognition as well as various other applications such as lip reading and speech recognition. DISC-SBHMMs consistently produce fewer errors than traditional HMMs and SBHMMs in recognizing ASL phrases using an instrumented glove. Probe achieves verification efficacy comparable to the optimum obtained from manually exhaustive search. Finally, when verifying phrases in CopyCat, BIG predicts which CopyCat phrases, even unseen in training, will have the best verification accuracy with results comparable to much more computationally intensive methods.

Thesis (M Sport Sc (Sport Science))--University of Stellenbosch, 2010.
ENGLISH ABSTRACT: The purpose of this study was to determine the impact of participation in a small group-based perceptual-motor training programme on the gross motor and visual-motor integration skills of children who show signs of Developmental Coordination Disorder (DCD). Two physical education teachers selected 22 children for assessment as potential participants for this study. The Movement ABC (M-ABC) was then administered to this group and the eight children who scored the lowest were invited to volunteer for this study. These children all volunteered and then completed the assessment of their visual-motor integration skills as measured by the Developmental Test of Visual Perception (DTVP-2). The study followed an evaluative case study design in which changes in the gross motor and visual-motor integration skills of each participant were reported and interpreted individually. The six-week intervention programme was focused on developing the perceptual-motor link between throwing, catching and balancing skills with challenges to visual skills development, especially eye-hand coordination. A comparison of pre-test, post-test and retention test scores in the M-ABC revealed that the programme had a positive effect on six of the children. The results for the seventh child were inconsistent on each test occasion, leading to the conclusion that he may have a co-morbid disorder related to attention. Improvements in static balance were noted and some children also experienced improvements in their ball skills (aiming and coincident timing) which brings the researcher to the conclusion that the programme was effective for gross motor development. DTVP-2 results showed improvements in eye-hand coordination in five of the seven children. According to the VMI quotient score, only one child improved, one deteriorated and the rest showed no change which brings the researcher to the conclusion that the intervention programme was not effective for visual-motor integration.
AFRIKAANSE OPSOMMING: Die doel van die studie was om die impak te bepaal van deelname in „n klein-groep gebaseerde perseptueel-motoriese oefenprogram op die groot motoriese en visueel-motoriese integrasievaardighede van kinders met tekens van die Ontwikkelingskoördinasie-afwyking (DCD). Twee Lewensoriëntering-onderwysers het 22 kinders geïdentifiseer vir assessering as potensiële deelnemers aan die studie. Hierdie groep het die Beweging-ABC toets (M-ABC) ondergaan en die agt deelnemers met die laagste uitslae is uitgenooi om aan die studie deel te neem. Hierdie agt kinders het ingestem en daarna is die assessering voltooi deur hulle visueel-motoriese integrasievaardighede te meet deur middel van die Ontwikkelingstoets vir Visuele Persepsie (DTVP-2). Die studie het „n evaluerende gevallestudie-ontwerp gevolg waarin die veranderings tussen die groot motoriese en visueel-motoriese integrasievaardighede van elke deelnemer individueel geïnterpreteer en gerapporteer is. Die ses week-intervensieprogram het gefokus op die ontwikkeling van die perseptueel-motoriese skakel tussen gooi-, vang- en balans-vaardighede met uitdagings vir die ontwikkeling van visuele vaardighede, veral oog-hand koördinasie. „n Vergelyking tussen die voor-, na- en opvolgtoetse van die M-ABC se toetstellings het getoon dat die program „n positiewe effek op ses van die kinders se groot motoriese vaardighede gehad het. Die uitslag van die sewende kind was teenstrydig tydens elke toetsgeleentheid en dit het gelei tot die gevolgtrekking dat hy moontlik aan „n addisionele afwyking mag ly wat verband hou met „n aandagprobleem. Verbeterings in statiese balans is waargeneem en sommige kinders het ook „n verbetering in balvaardighede getoon (akkuraatheid en reaksietyd). Volgens die DTVP-2 resultate was daar verbeterings in oog-hand koördinasie by vyf van die sewe kinders. Volgens die VMI-kwosiënttelling het slegs een kind verbeter, een het versleg en die ander vyf het geen verandering getoon nie. Die navorser kom dus tot die gevolgtrekking dat die intervensieprogram nie effektief is vir visueel-motoriese integrasie nie.

While the concept of teaching jazz style to vocal students is not a new one, previous materials written on the subject have not addressed two important aspects of this process. One is the concept of selecting jazz vocal solo repertoire that is both musically and vocally purposeful and appropriate for the student. The other is how to teach stylistic concepts that will apply to both current repertoire as well as songs the student will learn in the future. This doctoral essay provides both a categorized list of solo jazz vocal repertoire as well as strategies for introducing stylistic elements of jazz into the private-lesson setting. Through a systematic analysis of jazz vocal standards, a list of repertoire selections was categorized by rhythmic style, melodic range, melodic harmony, melodic rhythm, and harmonic content. In addition, the stylistic need to add syncopations to swing songs with non-syncopated melodies was addressed. Suggestions are included on how to implement this categorized list in the music selection process for students. Furthermore, this essay provides jazz voice teachers with strategies to efficiently incorporate important aspects of jazz styles such as rhythmic feel, song form, improvisation, and harmony into the lesson setting. By showing connections between these concepts and the literature that is being taught, students can become more competent and confident within the vocal and stylistic elements of the jazz idiom.

A Política Nacional dos Resíduos Sólidos (PNRS) instituída em 2010 previa a destinação final ambientalmente adequada dos resíduos, no entanto, o prazo venceu em 2014 e o objetivo não foi alcançado. O aterro sanitário, na hierarquia da gestão integrada de Resíduos Sólidos Urbanos (RSU), é a última opção, mas não a menos importante dentre as possibilidades de destinação final ambientalmente adequada, pois é a infraestrutura de tratamento e destino final que pode receber uma gama variada de RSU de forma ambientalmente segura. O Consórcio Público é um instrumento previsto na PNRS para que os municípios possam se associar, obtendo economia de escala viabilizando a operação de aterros sanitários de forma compartilhada. Porém, com o compartilhamento dos aterros sanitários surge a questão do custo de transporte do RSU, uma vez que os municípios depositarão seus resíduos fora do seu território. Dessa forma este trabalho objetivou identificar áreas adequadas para a localização de aterros sanitários, considerando os aterros sanitários já existentes na Unidade de Gerenciamento de Recursos Hídricos (UGRHI) 5 e, utilizar modelos matemáticos que minimizem os custos de transporte de RSU e operação dos aterros sanitários. Para alcançar os objetivos propostos utilizou-se do método de seleção de áreas adequadas para a localização de aterros sanitários, desenvolvido em ambiente SIG e composto pelo estabelecimento de critérios ambientais, sociais e econômicos que foram classificados de acordo com níveis de adequação e ponderados através de Análise de Decisão Multicritério (MCDA), resultando em um mapa de adequação, que foi cruzado com o mapa de áreas de restrição, gerado em cenários de escalas diferentes, obtendo assim, o mapa final de adequação - cenário 1 e 2. A esses cenários, foram sobrepostos os aterros sanitários existentes. A otimização da rede de transporte de RSU consistiu em um modelo matemático de estrutura de Programação Quadrática Inteira Mista (MIQP). Na função objetivo foram incorporadas as distâncias para a obtenção da localização ótima dos aterros sanitários existentes em áreas adequadas, estando sujeita as restrições de ordem física e comportamental. No cenário 1, identificou-se que 62% da área da UGRHI 5 é classificada como adequada para a localização de aterros sanitários, 15% como de média adequação e 23% como de restrição e, dos 18 aterros sanitários existentes, 14 estão localizados em áreas adequadas. No cenário 2, identificou-se que 30% da área é considerada adequada, 5% como de média adequação e 65% como de restrição e, apenas 7 aterros sanitários estão localizados em áreas adequadas. A aplicação do modelo de otimização para o cenário 1, resultou em 5 aterros sanitários como solução ótima, já no cenário 2 a solução ótima é de 4 aterros. Considerando que o cenário 2 possui características mais restritivas que o 1; que o aumento do custo total diário do cenário 1 para o 2 é de apenas 7,56% e que a capacidade total atual dos aterros sofreria uma redução de apenas 1,5%, pode-se concluir que o cenário 2 é o mais apropriado para a formação de consórcios públicos na UGRHI 5.
The National Policy of Solid Waste (NPSW) established in 2010 provided for the environmentally suitable final destination of waste, however, the deadline expired in 2014 and the goal was not achieved. The landfill, in the hierarchy of the integrated management of Municipal Solid Waste (MSW), is the last option, but not the least important one amongst the possibilities for environmentally suitable final destination, because it is the infrastructure of treatment and final destination which can receive a varied range of MSW in an environmentally safe way. The Public Consortium is an instrument provided for in the NPSW so that the cities can join in, achieving scale economy allowing the shared landfill operation. However, with the share of landfills comes the problem of MSW transportation costs, since the cities will deposit their waste outside their territories. Thus, this study aimed to identify appropriate areas for the setting of landfills, considering the landfills already existing in the Water Resources Management Units (WRMU) 5, and use mathematical models that minimize the MSW transportation costs and landfill operation. To achieve the proposed goals it was used the selection method of suitable areas for landfill setting, developed in GIS environment and consisting of the establishment of environmental, social and economic criteria which were classified according to the adequacy levels and considered by the Multi Criteria Decision Analysis (MCDA), resulting in an adequacy map, which was cross-checked with the restriction area map generated at different scale scenarios, thereby obtaining the final adequacy map - scenarios 1 and 2. On these scenarios, the existing landfills were overlapped. The MSW transportation network optimization consisted of a mathematical model of Mixed Integer Quadratic Programming structure (MIQP). In the objective function the distances were incorporated to obtain the optimal location of the existing landfills in appropriate areas, which are subject to restrictions of physical and behavioral order. In scenario 1, it was identified that 62% of the WRMU 5 area is classified as adequate for the setting of landfills, 15% as average adequate and 23% restricted, and from the 18 existing landfills, 14 are located in suitable areas. In scenario 2, it was identified that 30% of the area is considered adequate, 5% average adequate and 65 % restricted, and only 7 landfills are located in suitable areas. The application of the optimization model for scenario 1 resulted in 5 landfills as an optimal solution, yet, in scenario 2 the optimal solution is of 4 landfills. Considering that scenario 2 has more restrictive characteristics than scenario 1; the total daily cost increase of scenario 1 compared with 2 is only 7.56% and that the total current capacity of the landfills would suffer a reduction of only 1.5%, it can be concluded that scenario 2 is the more suitable for the formation of public consortium in WRMU 5.

This master's thesis deals with the localization, detection and recognition of traffic signs. The possibilities of selection of areas with possible traffic signs occurrence are analysed. The properties of different kinds of features used for traffic signs recognition are described next. It focuses on the features based on histogram of oriented gradients. Some possible classifiers are discussed, in the first place the cascade of support vector machines, which are used in resulting system. A description of the system implementation and data sets for 5 types of traffic signs is part of this thesis. Many experiments were accomplished with created system. The results of the experiments are very good. New datasets were acquired from approximately 9 hours of processed video sequences. There are about 13 500 images in these datasets.

Les pénuries d'électricité sont un problème mondial majeur à cause de l'augmentation de la demande d'électricité, c'est pourquoi l’implémentation des énergies renouvelables(ER) est une solution alternative importante pour répondre à nos besoins en électricité, en réduisant les émissions de gaz à effet de serre pour lutter contre le changement climatique et d'atténuer la dépendance à l'égard des ressources en combustibles fossiles. Ainsi, la planification de la transition vers les ER est une stratégie essentielle que le réseau électrique soit connecté au nationale ou hors dans les zones rurales. La plupart des pays sont déjà commencé à renforcer leurs infrastructures énergétiques pour les alimenter à partir de ressources ER durables, mais les ressources potentielles limitées pourraient arrêter ce déploiement. L’intégration de différentes ressources d'ER au réseau électrique est un enjeu majeur pour assurer la stabilité et l’implémentation de systèmes d'ER à rendement nécessite à la prise de décision pour encourager d'investissement. Donc, la planification des ER doit être évaluée à partir des critères technico-économiques et socio-environnementaux. Cette thèse surligner le concept principal de la transition 100 % ER d’ici fin 2030 en Guyane française où il y a un enjeu dans l'élaboration du scénario énergétique d'ici 2030 et les centrales électriques actuelles ne peuvent pas se nourrir l'augmentation de la demande d'électricité avec des ressources limitées. En résumé, cette thèse répondra à la question : comment optimiser différents scénarios de production d'énergie en tenant compte des dimensions spatio-temporelles du problème et des données
Currently, lack of electricity is a major global issue around the world due to the increase in power demand, that’s why implementation of renewable energy(RE) is an important alternative solution to feed our electricity needs, reducing Green House Gases (GHG) emissions to fight climate change and to mitigate the dependency on fossil fuels resources. So, (RE) transition planning is an essential ongoing strategy to feed our demand needs whether the network is grid-connected or off-grid in rural areas. Most countries have already begun to reinforce its energy infrastructure to be fed from sustainable (RE) resources but the limited potential resources could halt such deployment. So, integration of different renewable energy resources to the power network is a major challenge to secure the stability of the grid and the implementation of efficient (RE) systems requires strong decision making support to encourage investments. Thus, (RE) planning should be evaluated from the techno-economic-socio-environmental criteria. This thesis highlights the main concept of 100 % renewable energy transition by the end of 2030 in French Guiana where there is a challenge in the development of the energetic scenario by 2030 and the current energy production facilities cannot feed the increase in power demand within limited resources. As a summary, this thesis handles this research question: how to optimize different energy production scenarios combining different RE resources of maximum production at minimal costs in order to satisfy the energy needs taking into account the spatio-temporal dimensions of the problem and data?

Submitted in fulfillment of the requirements of the degree of Master of Technology: Language Practice, Department of Media, Language and Communication, Durban University of Technology, Durban, South Africa, 2016.
IsiZulu is a previously marginalized language and is spoken by 78% of people in KwaZulu-Natal (South Africa.info 2012). Signed language on the other hand, is not an official language in South Africa, although it is recognised despite the profession having undergone major transformation since democracy. This study hypothesizes that isiZulu and South African Sign Language interpreters both face challenges when given interpreting assignments. This study aims to create an awareness of the needs of the isiZulu speakers and deaf people when seeking judicial assistance and also to contribute towards the provision of quality interpreting services in some of the courts in KwaZulu-Natal. With this study it is hoped to assist the Department of Justice and Constitutional Development to be able to see where they can still improve on their system. This study was conducted only in four courts, therefore, the findings cannot be generalized to be the same in all the courts in South Africa. IsiZulu kusewulimi obelucindezelwe, kanti lusetshenziswa abantu abangamaphesenti angama-78 KwaZulu-Natali (SouthAfrica.info 2012). Ulimi lwezandla ngakolunye uhlangothi, akulona ulimi olusemthethweni eNingizimu Afrika nangale koshintsho oluningi olwenziwe kusukela kwaqala intando yabantu. Lolu cwaningo lucabangela ukuthi otolika besiZulu kanye naboLimi Lwezandla babhekana nezingqinamba uma benikwe umsebenzi wokutolika. Lolu cwaningo Iuhlose ukwazisa ngezidingo zabantu abakhuluma isiZulu kanye nabangezwa uma bedinga usizo lwezomthetho kanye nokuxhasa ekunikezeleni ukutolika okusezingeni elifanele kwezinye zezinkantolo KwaZulu-Natali. Ngalolu cwaningo kuthenjwa ukuthi luzosiza uMnyango Wobulungiswa kanye nokuThuthukiswa koMthethosisekelo ukuba ubone ukuthi yikuphi la okungalungiswa khona inqubo yokwenza yawo. Lolu cwaningo lwenziwe ezinkantolo ezine kuphela, ngakho-ke okutholakele ngeke kuze kuthathwe ngokuthi kuyafana ezinkantolo zonke zaseNingizimu Afrika.
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In this thesis, the author developed a retroreflective sheeting selection technique for traffic signs. Previous research was used to determine the luminance needed by drivers (demand luminance). The author used roadways scenarios to determine the amount of luminance the retroreflective sheeting on a sign would produce (supply luminance). A spreadsheet was developed to determine the performance of different retroreflective sheeting types by comparing the demand and supply luminance for specific roadway scenarios. Using the results of previous studies, three demand luminance levels were created: replacement, adequate, and desirable. The replacement level represents the level of luminance when a sign needs to be replaced and is 2.5 cd/m2. The adequate level is the recommended amount of luminance when installing new traffic signs and is 10 cd/m2. The desirable level is the approximate level when additional luminance has diminishing returns and is 30 cd/m2. Supply luminance on a specific traffic sign was determined by evaluating roadway geometries, sign placement, retroreflective sheeting type and vehicle data. The author reviewed roadway geometries in Texas to estimate typical number of lanes, shoulder widths and horizontal curvature in the US. Sign placement from the MUTCD determined the typical lateral placements, sign heights, and sign twists. Vehicle data included vehicle dimensions and headlamp type. Both the supply and demand luminance were determined for a specific viewing distance for a given scenario. The viewing distance is the distance a driver needs to read or recognize a sign to respond properly. In addition, the type of sign, alphanumeric or symbol, determined how this distance was calculated. The author developed four sign groups to calculate the distance required to read and respond to a traffic sign, including 1) Stop required, 2) Reduction in speed required, 3) Read the message provided, and 4) Change of lane required. For symbol signs, the minimum required visibility distance (MRVD) was determined for the sign group and for text signs, the viewing distance at a legibility index (LI) of 30 ft/in was found. At these distances, the author calculated the supply luminance and then compared it to the demand luminance levels to determine the performance level. The author developed the Retroreflective Sheeting Selection Spreadsheet (RSSS) to allow others to use the methodology presented in this thesis. RSSS allows users to input the roadway data, vehicle data, and sign data. RSSS takes this information and looks up the supply luminance for the scenario. RSSS then compares the supply luminance to the demand luminance levels and outputs the retroreflective sheeting performance level for the scenario.

Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia
Ensaios de fase I são os primeiros estudos farmacológicos em humanos, sem objetivos terapêuticos e frequentemente incluem indivíduos saudáveis administrados com um medicamento experimental ou um placebo. A minimização do risco ao nível mais baixo possível implica a implementação de medidas de segurança, particularmente em estudos pioneiros em humanos com um novo composto sob investigação. O estado de saúde dos participantes e o cumprimento dos critérios de elegibilidade deve ser avaliado no início do estudo, durante o período de triagem, para garantir e proteger o bem-estar de todos os indivíduos. As avaliações de triagem incluem, em geral, a história médica, exame físico, sinais vitais, exames laboratoriais e eletrocardiograma. Em todas as circunstâncias, o investigador é responsável pela vigilância clínica e cuidados médicos. Atualmente, nenhuma diretriz define os intervalos aceitáveis para os principais parâmetros de segurança que permitem a participação de um sujeito saudável em ensaios clínicos de fase I. Pequenos desvios dos intervalos de referência podem ser aceites no contexto de elegibilidade para um ensaio, por não serem necessariamente patológicos. Os parâmetros de segurança escolhidos para elegibilidade e os valores definidos como aceitáveis dependerão sempre do risco do medicamento, considerando os órgãos alvo de toxicidade. Ao longo deste trabalho, será discutido um intervalo de aceitabilidade para sinais vitais e parâmetros do eletrocardiograma de um centro de fase I. Os dados recolhidos de 16 estudos serão utilizados para analisar anormalidades morfológicas do eletrocardiograma no mesmo coorte saudável, fornecendo informações fidedignas acerca da segurança dos participantes.
Phase I trials are the first pharmacological studies in humans, without therapeutic objectives and often include healthy subjects administered either an active investigational drug or a placebo. Risk minimization to the lowest possible level implies the implementation of safety measures, particularly in first-in-human studies with a new compound under investigation. The health status of participants and the compliance with the eligibility criteria must be assessed at the beginning of the trial, during the screening period, to ensure and protect the well-being of all subjects. Screening assessments include, in general, medical history, physical examination, vital signs, laboratory tests and electrocardiogram. At all times, the investigator is responsible for the clinical surveillance and medical care. Currently, no guidelines define the acceptable ranges for the main safety parameters used for the participation of a healthy subject in a phase I clinical trial. Minor deviations from the reference ranges may be accepted in the context of eligibility for a trial as they are not necessarily pathological. The safety parameters chosen for eligibility and the values defined as acceptable will always depend on the risk of the drug, considering the target organs of toxicity. Throughout this work, an acceptability range for vital signs and electrocardiogram parameters in one phase I center will be discussed. Data collected from 16 studies will be used to analyze electrocardiogram morphological abnormalities in the same healthy cohort, providing reliable information on subjects’ safety.

The rediscovery of the Sing-Akademie of Berlin manuscript collection in Kiev and its eventual repatriation in 2001, has had a significant impact upon music scholarship. In addition to discoveries of new sources from leading composers, the collection sheds light on the output of more obscure composers of the eighteenth and nineteenth centuries. Among the 5,100 autograph scores and manuscript copies are a number of mid-eighteenth-century works featuring obbligato bassoon. This doctoral research has focused on five unpublished works from the collection: a Trio for Oboe, Bassoon and Continuo attributed to Telemann; a Quartet for Oboe, Violin, Bassoon and Violoncello by Christian Gottfried Krause, and three compositions of Johann Christian Roellig—a Concerto for Bassoon and two Partitas featuring obbligato Bassoon. This research has been conducted to enable and inform performances of these works included in the folio that forms part of this submission. Critical editions were prepared based on manuscripts now held in the Staatsbibliothek zu Berlin–Preußischer Kulturbesitz enabling the first modern performances of these works presented throughout four public recitals on period instruments. The critical editions are included as appendices to the exegesis, which contextualises the research underpinning these outcomes. The exegesis provides an overview of the provenance of the manuscripts, the editorial process, and discusses the musical style and historically informed interpretation of these newly discovered works as documented in the folio recordings. Outcomes include insights into mid-eighteenth-century performance practices and original findings relating to the identification of the primary source material of the two Partitas by Johann Christian Roellig. These five new critical editions constitute an important contribution to the bassoon repertoire. The world premiere recordings included in this thesis vi demonstrate historically informed interpretations and new insights into performing practice that will inspire further performances, advocating for their return to the repertory.

In my thesis I deal with a biblical "myth" of the original sin and with a question how this topic can demonstrate the genesis of gender duality in a sense of superiority and inferiority using the authors catholic and feminist theology and subsequent data collection. The topic of the original sin is being analysed from a gender view -first in the theoretical part of the thesis that has helped me to continue to the following part of a research. The research consists of semi-structured interviews with a group of people belonging to a specific community. These people were born in the Czech villages in Romania and live nowadays in the Czech Republic. The original sin and its "myth" are still being presented at the level of a myth. His consequences remain in the background of the society and public attention. That is why I decided to deal with this topic. In this way I connect my own interest with this group, which includes a minority of a society with special characteristics. The aim of this thesis is to present the consequences of the original sin on a theoretical level and in terms of research, which I also contribute to with my interviews. And so to answer the research question regarding the influence of minority companies mostly from the standpoint of faith.