Дисертації з теми "SHTG"
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Sanchez, Washington. "Modulation of the SHBG signalling axis." Queensland University of Technology, 2009. http://eprints.qut.edu.au/28604/.
Повний текст джерелаSanchez, Washington Yamanda. "Modulation of the SHBG signalling axis." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/28604/2/Washington_Sanchez_Thesis.pdf.
Повний текст джерелаGrishkovskaya, Irina. "Kristallographische Studie zum Sexualhormon-bindenden Globulin (SHBG)." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/66/index.html.
Повний текст джерелаDUMOULIN, SYLVIE. "Effet des hormones thyroidiennes sur les glycoproteines de transport des steroides, shbg et cbg sur le rapport gbg/shbg." Toulouse 3, 1993. http://www.theses.fr/1993TOU31535.
Повний текст джерелаAebiacher, Nicholas J. "Aspects of the biology of the shag (Palacrocorax aristotelis)." Thesis, Durham University, 1985. http://etheses.dur.ac.uk/7880/.
Повний текст джерелаHall, Margaret Emily. "Senescence and reproductive performance in the European shag (Phalacrocorax aristotelis)." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404641.
Повний текст джерелаJänne, Marja. "Regulation of human sex hormone-binding globulin gene (shbg) expression." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/janne/.
Повний текст джерелаKing, Ruth. "Bayesian model discrimination in the analysis of capture-recapture and related data." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391229.
Повний текст джерелаПетровський, А. А., та І. О. Товкач. "Модуль захисту авторизації системи «ПОЛІДАР» на основі гібридного алгоритму W-SHAG". Thesis, Cумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47084.
Повний текст джерелаPodeur, Vincent. "Modélisation expérimentale et numérique du power take-off d’un bassin houlomoteur." Electronic Thesis or Diss., Brest, École nationale supérieure de techniques avancées Bretagne, 2022. http://www.theses.fr/2022ENTA0005.
Повний текст джерелаThe present work aims at studying the power take-off of a wave energy converter (WEC). This system is composed of a set of connected tanks. Rubber flaps are installed at tanks inlet and outlet to ensure a one-way flow direction. Thanks to wave induced motions of the supporting platform, sloshing appears inside the WEC tanks which feed a cylindrical basin with a centered drain hole at its bottom. Then, a bathtub vortex flow appears within this tank, where a vertical axis turbine is installed to harvest kinetic energy from the flow. The first phase of this research focuses on studying the steady bathtub flow. To do so, a dedicated experiment is built. Velocity field within the cylindrical basin, with and without the turbine, is studied via Particle Image Velocimetry (PIV). In addition, power production from the turbine and water level inside the tank are measured. These results are used to define starting hypothesis for developing a numerical model of the turbine. The second phase of this research focuses on studying the unsteady bathtub flow. For this purpose, a second experiment is built. This setup provides a more realistic environment, closer to what can be observed with the WEC system. PIV measurements are also used extensively to study the flow with and without the turbine. The last stage of this research focuses on the numerical modelling of the vertical axis turbine. The model is based on the potential flow theory. First, a two-dimensional approach is used to validate the early pieces of the model. Secondly, a three-dimensional approach is adopted to account for more complex flow features. Finally, numerical and experiment results are compared
Heeg, Bauke. "An electrochemical and SHG study of corrosion inhibition." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625055.
Повний текст джерелаMausch, Kersten Magdalena. "Pubertätsgynäkomastie Östrogen- und Progesteronrezeptorbestimmung bei Pubertätsgynäkomastie- und Vergleichsgewebe ; pathophysiologische Bedeutung, SHBG, Histologie /." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=960458484.
Повний текст джерелаJanusiewicz, Anna. "A Product of Womanism: Shug Avery in Alice Walker's The Color Purple." Thesis, Högskolan i Gävle, Avdelningen för humaniora, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-19243.
Повний текст джерелаGebhardt, Philipp. "Kosten-Nutzenanalyse in der SHT (Schädel-Hirn-Trauma) - Diagnostik." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-156917.
Повний текст джерелаHutchison, J. "Interfacial dynamics of surfactants studied using SHG and ellipsometry." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604860.
Повний текст джерелаMoore, Sam S. B. Massachusetts Institute of Technology. "Implementation of side-fringe locking in an SHG cavity." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105652.
Повний текст джерелаPages 36-39 are missing. Cataloged from PDF version of thesis.
Includes bibliographical references (pages 40-41).
An alternative method for locking a second-harmonic generation (SHG) cavity on resonance is described and implemented. The usual method, Pound-Drever-Hall locking, is prone to long-term power fluctuations from power variations in the incident laser. When using the second harmonic field for squeezing, these power fluctuations need to be stabilized with an additional control loop (usually a Mach-Zender interferometer). The alternative method, side-fringe locking, involves a simple DC offset on the second-harmonic signal at the desired power to generate the error signal. This thesis demonstrates the insensitivity of side-fringe locking to such long-term power fluctuations and that the noise spectrum is comparable to PDH locking-explained largely due to PZT noise length fluctuations off-resonance..
by Sam Moore.
S.B.
Sáez, López Cristina. "Mecanismos moleculares que regulan la expresión de la shbg: implicaciones en la obesidad." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/392712.
Повний текст джерелаSex Hormone-Binding Globulin (SHBG) is synthesized by human liver and secreted into the blood, where it binds with high affinity androgens and estrogens, regulating their bioavailability and accesibility at tissue level. SHBG levels are low in obese people of all age and are negatively correlated with body mass index. Besides obesity, plasma SHBG levels are low in other metabolic pathologies such as type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and predict the risk of cardiovascular disease (CVD). In this thesis, we have described the molecular mechanisms that regulate SHBG expression during obesity development through the generation of a new transgenic mouse model. Besides, we have searched for new factors that regulate SHBG production and the molecular mechanisms involved have been studied. Finally, we have studied whether SHBG plays a role in the development and progression of NAFLD, one of the obesity-related pathologies. In the first place, through the development of a double transgenic mouse model which is obese and diabetic and that expresses SHBG (SHBG-db/db mouse), we have observed that at hepatic level, PPARγ upregulation and HNF-4α downregulation are responsible for the decrease in SHBG levels during obesity development. Besides, by using this SHBG-db/db mouse model, which presents NAFLD, and a NAFLD model induced by high fructose diet, we have demonstrated that SHBG overexpression downregulates hepatic lipogenesis and protects them against fatty liver development. By the use of the cell line HepG2 as in vitro model, we have confirmed that the modulation of SHBG levels affects lipogenesis. We have concluded that SHBG reduction in NAFLD patients would play a role in the development of this disease. In the second place, we have found new factors that regulate SHBG production: adiponectin as metabolic factor and oleic acid as nutritional factor, and we have described the molecular mechanisms involved in such regulation. In the case of adiponectin, given the positive correlations between SHBG and adiponectin plasma levels, and that their levels are decreased in obese patients, we have studied whether this relation is causal. By the use of HepG2 cells, we have found that adiponectin increases SHBG hepatic expression through the activation of AMPK, which produces an increase in fatty acid oxidation and a decrease in lipogenesis, giving rise to an increase of HNF-4α hepatic levels, thus activating SHBG expression. Furthermore, in hepatic biopsies and human plasma, the correlation between adiponectin levels and SHBG and HNF-4α was confirmed. On the other hand, the study of SHBG regulation by oleic acid originates from the fact that low SHBG plasma levels constitute an independent indicator of CVD risk, and olive oil consumption, rich in oleic acid, protects against the development of CVD. Because of this, our objective was to investigate whether the cardioprotective effect of olive oil is mediated in part by SHBG increase. In colaboration with the Endocrinology and Nutrition Group from Carlos Haya Hospital (Málaga) in the frame of the study PIZARRA, we observed that olive oil consumption increased plasma SHBG levels in men. In HepG2 cells, this increment was confirmed and it was demonstrated that it is due to PPARγ downregulation induced by oleic acid.
杜偉麒 and Wai-ki Alex Tu. "Molecular cloning and characterization of rabbit sex hormone binding globulin (SHBG) complementary DNA." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31213716.
Повний текст джерелаDaunt, Francis H. J. "The effects of parental age on reproductive performance in the shag Phalacrocorax aristotelis." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340330.
Повний текст джерелаTu, Wai-ki Alex. "Molecular cloning and characterization of rabbit sex hormone binding globulin (SHBG) complementary DNA /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14786965.
Повний текст джерелаGrist, Hannah. "Patterns and consequences of variation in winter location in a partially migratory population of European shags." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225313.
Повний текст джерелаSantos, Carla Sofia Veríssimo Duarte dos. "A formação em SHT vs. sinistralidade laboral na limpeza urbana." Master's thesis, Escola Superior de Ciências Empresariais, 2013. http://hdl.handle.net/10400.26/4432.
Повний текст джерелаO presente estudo tem como objetivo principal identificar a relação entre a formação na área da segurança e higiene do trabalho e a ocorrência de acidentes de trabalho na função de cantoneiro de limpeza, ou seja, perceber se a formação ministrada tem efeitos na diminuição da sinistralidade laboral. Este estudo foi realizado na Câmara Municipal de Lisboa, especificamente na Divisão de Limpeza Urbana, tendo sido utilizada como metodologia, a análise de uma amostra do total de cantoneiros de limpeza, bem como a realização de uma entrevista semiestruturada a elementos da unidade orgânica em questão, com relevância ao nível do processo formativo. Dos resultados obtidos constata-se principalmente que não existe uma relação direta e evidente entre a formação ministrada em SHT aos cantoneiros de limpeza e a sinistralidade laboral nessa função, havendo no entanto outras variáveis que podem contribuir para a ocorrência de acidentes de trabalho. Os resultados obtidos poderão permitir, face ao tema abordado, percecionar a adequabilidade e eficácia do processo formativo em segurança e higiene do trabalho, relativamente à função de cantoneiro de limpeza.
This study's main objective is to identify the relationship between training in safety and hygiene at work and the occurrence of accidents in the function of street cleaning, ie perceiving that the training provided has effects in reducing accidents at work. This study was conducted at the Lisbon City Council, specifically the Division of Urban Cleaning, having been used as a methodology, analysis of a representative sample of the total street cleaners as well as conducting a semistructured interview to elements of the organizational unit in question with relevance to the level of the training process. From the results it is clear that there isn’t a direct and evident relation between the training provided in safety and hygiene at work to street cleaners and work accidents in this role, however there are other variables that may contribute to the occurrence of accidents. The results may allow, given the subject matter, understand the adequacy and effectiveness of the training process in safety and hygiene in relation to the function of street cleaning.
Shephard, Emily Laura Cairns. "Strategies for efficient foraging in a deep-diving bird, the imperial shag (Phalacrocorax atriceps)." Thesis, Swansea University, 2009. https://cronfa.swan.ac.uk/Record/cronfa42298.
Повний текст джерелаKsianzou, Viachaslau. "Second-order nonlinear optical interactions and cascading effects in thinorganic films." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4918/.
Повний текст джерелаDie vorliegende Arbeit beschreibt neue Konzepte für schnelle photonische Schaltelemente. Diese Elemente basieren auf optischer Wellenleitung im sichtbaren und nahen infraroten Spektralbereich. Die Arbeit ist auf organische Wellenleiter aus transparenten, farbstoffdotierten Polymeren fokussiert, welche Chromophore mit besonders großen optischen Nichtlinearitäten zweiter Ordnung enthalten. Insbesondere wird dargestellt, wie nichtlineare optische Prozesse in derartigen Bauelementen genutzt werden können, wenn man elektrische oder optische Steuersignale einsetzt. Es wird der gesamte Her-stellungszyklus verschiedener integrierter photonischer Bauelemente betrachtet. Die Arbeit umfasst weiterhin eine detaillierte theoretische Analyse der Wellenausbreitung in Medien mit großer nichtlinearer optischer Suszeptibilität zweiter Ordnung bei hoher Lichtintensität. Unter Annahme optischer Materialkonstanten, welche den experimentell ermittelten Werten entsprechen, erfolgte eine quantitative Abschätzung für das Auftreten von Szenarien, bei denen messbare Abwei-chungen der Strahlausbreitung vom linearen Regime auftreten, z:B. das Auftreten von zeitlichen, räumlichen und spektralen Satteliten zu den im Material propagierenden Laserpulsen. Es gelang, we-sentliche Aspekte der Strahlpropagationsprozesse durch Anwendung von Jacobi-Integralfunktionen in geschlossener mathematischer Form darzustellen. Darüber hinausgehende theoretische Untersuchungen nutzten die Finite-Elemente-Methode, um die Verteilung des elektromagnetischen Feldes im Inneren optischer Wellenleiter für verschiedene Pro-pagationsmoden zu analysieren. Ein weiterer Teil der Arbeit beschäftigt sich mit organischen Kompositmaterialen, welche große opti-sche Nichtlinearitäten aufweisen. Mittels quantenchemischer Verfahren erfolgte eine detaillierte Un-tersuchung der Zusammenhänge zwischen der molekularen Struktur und den linearen sowie den nichtlinearen optischen Eigenschaften der untersuchten Farbstoffmoleküle und Polymere. In Bezug auf die Probenpräparation sind unterschiedliche Verfahren zur Schichtbildung und zur molekularen Orientierung miteinander verglichen und bewertet worden, da letztere eine Voraussetzung für das Auftreten nichtlinearer optischer Prozesse zweiter Ordnung bildet. Die Untersuchungen erstreckten sich auf Vakuumaufdampfschichten aus niedermolekularen Chromophoren und auf Polymerschich-ten, welche durch Vakuumabscheidung sowie durch Spincoating oder andere Flüssigphasenabschei-dungsverfahren hergestellt worden sind. Auf orientierenden Substraten (z.B. geriebene Schichten aus Polytetrafluoräthylen) konnte eine spontane Orientierung der deponierten Chromophore nachgewie-sen werden. Die Chromophore in Polymerschichten wurden durch Coronapolung orientiert. In der Arbeit ist zum ersten Mal vorgeschlagen worden, eine räumliche Modulation der nichtlinearen optischen Eigenschaften durch gezielte lokale Coronapolung oder andere Orientierungstechniken derart zu generieren, dass die Abfolge gepolter Domänen dem Bildungsgesetz einer modifizierten Fibonacci-Reihe mit gebrochen rationalen Zahlen gehorcht. Der Vorteil von optischen Wellenleitern mit dieser Struktur darin, dass diese mehrere unterschiedli-che nichtlineare optische Prozesse gleichzeitig unterstützen und somit eine Vielzahl neuartiger Phä-nomene auftreten kann, welche man in neuartigen photonischen Bauelementen, z.B. für die optische Informations- und Kommunikationstechnik nutzen kann. Der letzte Teil der Arbeit beschreibt den Aufbau verschiedener integrierter optischer Modulatoren und Schalter, die sich mit Hilfe das neu entwickelten Verfahrens herstellen lassen. Zukünftige Entwicklungen in der Photonik, insbesondere der optischen Informations- und Kommuni-kationstechnik werden im abschließenden Teil der Arbeit diskutiert.
Vismer, Michael John. "An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19887.
Повний текст джерелаENGLISH ABSTRACT: The aim of this study was to build a mathematical model that describes the binding of 17- -estradiol (E2) to estrogen receptor (ER- ) and the influence the sex hormone binding globulin (SHBG) has on this interaction. The influence of SHBG on the transactivation of an estrogen response element, via ligand bound ER- , was also studied. COS-1 cells, derived from the kidney of a green african monkey, were used to study the binding of E2 to ER- in the absence of SHBG. The influence of SHBG on the binding of E2 to ER- was studied using Hep89 cells, human hepatacoma carcinoma, which express SHBG endogenously and are stably transfected with the ER- gene. Human pregnancy plasma was used to study the interaction of E2 with SHBG in the absence of ER- . The results of this study have shown that the Kd (E2) for ER- was determined as between 3.4nM and 4.4nM in the absence of SHBG. With respect to the binding of E2 to ER- it was not possible to determine the Kd app and Bmax for ER- using the Hep89 experimental system. The Kd (E2) for SHBG was not determined using the human pregnancy plasma experimental system. With the aid of mathematical modelling, a model of the Hep89 and human pregnancy plasma experimental systems, was built. The results of the numerical modelling, using mathematical modelling, showed that the presence of albumin together with SHBG was the reason that the Kd app (E2) could not be determined in the Hep89 experimental system. With respect to the use of human pregnancy plasma to determine the Kd (E2) for SHBG it was shown that if the plasma was diluted 200 times it would have been possible to determine the Kd app (E2) for SHBG, in the presence of albumin. Ligand independent transactivation of an estrogen response element was shown to be a problem in the COS-1 cell system when promoter reporter gene assays were undertaken. As COS-1 cells were used as a control for the absence of SHBG no further promoter reporter gene assays were undertaken using the Hep89 experimental system.
AFRIKAANSE OPSOMMING: Die doel van hierdie studie was die bou van ‘n wiskundige model wat die verbinding van E2 met die estrogeenreseptor (ER- ) en die invloed wat die geslagshormoon-verbindingglobulien (SHBG) op hierdie interaksie het, beskryf. Die effek van SHBG op die transaktivering van ‘n estrogeen responselement, via die ligandverbonde ER- , is ook bestudeer. COS-1-selle uit die nier van ‘n groen afrika-aap is gebruik om die verbinding van E2 met ER- in die afwesigheid van SHBG te bestudeer. Die invloed van SHBG op die verbinding van E2 met ER- , is bestudeer deur gebruik te maak van Hep89-selle, die menslike lewergeswelkarsinoom, wat SHBG uitwendig afgee en wat stabiel getransfesteer kan word met die ER- geen. Menslike swangerskapplasma is gebruik om die interaksie van E2 met SHBG in die afwesigheid van ER- te bestudeer. Die uitslag van hierdie studie toon aan dat die Kd (E2) vir ER- vasgestel tussen 3.4nM en 4.4nM in die afwesigheid van SHBG. Met betrekking tot die verbinding van E2 met ER- , was dit nie moontlik om die Kd (E2) en Bmax app vir ER- met die gebruik van die Hep89 eksperimentele stelsel vas te stel nie. Die Kd (E2) vir SHBG is nie vasgestel deur die gebruik van die menslike swangerskapplasma eksperimentele stelsel nie. ‘n Model van die Hep89 en menslike swangerskapplasma eksperimentele stelsels is met behulp van wiskundige modellering gebou. Die uitslag van die numeriese modellering, met gebruik van wiskundige modellering, toon dat die teenwoordigheid van albumien, saam met SHBG, die rede was dat die Kd app (E2) nie in die Hep89 eksperimentele stelsel vasgestel kon word nie. Wat betref die gebruik van menslike swangerskapplasma om die Kd (E2) vir SHBG vas te stel, is daar aangetoon dat, indien die plasma 200 maal verdun was, dit moontlik sou gewees het om die Kd app (E2) vir SHBG in die teenwoordigheid van albumien vas te stel. Promotor verkilkkergeen toetse het ligandonafhanklike transaktiveering van ‘n estrogeen responselement aangetoon as ‘n probleem in die COS-1-selle stelsel. Omdat COS-1-selle gebruik is as ‘n kontrole vir die afwesigheid van SHBG, is geen verdere promotor verkilkkergeen toetse onderneem met die gebruik van die Hep89 eksperimentele stelsel nie.
DE, GLISEZINSKI ISABELLE. "Interet du dosage de la shbg dans l'evaluation du statut nutritionnel chez la personne agee." Toulouse 3, 1993. http://www.theses.fr/1993TOU31555.
Повний текст джерелаYin, Yan. "Silica Fiber with Large and Thermodynamically Stable Second Order Optical Nonlinearity." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32266.
Повний текст джерелаMaster of Science
Martínez, Selvas David. "Accions alternatives de la proteïna transportadora d'esteroids sexuals (SHBG/ABP) a l'espermatogènesi i al càncer de pròstata." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/3466.
Повний текст джерела1) A l'espermatogènesi s'ha treballat amb dos models diferents, un és el ratolí transgènic que sobreexpressa la SHBG/ABP de rata i l'altre el ratolí transgènic que sobreexpressa la SHBG/ABP humana.
a) Ratolí transgènic per la SHBG/ABP de rata. La sobreexpressió del transgen de rata a nivell del testicle provoca un bloqueig parcial de la primera divisió meiòtica i un augment de la mort cel.lular programada o apoptosi de les cèl.lules germinals, especificament d'espermatocits primaris i cèl.lules en meiosi. Aquestes cèl.lules apoptòtiques sobreexpressen el mRNA i la proteïna del receptor d'estrògens beta. La proteïna, a més a més, s'acumula a nivell del citoplasma d'aquestes cèl.lules apoptòtiques.
b) Ratolí transgènic per la SHBG/ABP humana. El trànscrit que s'expressa a nivell del testicle de la linia shbg11 prové del promotor alternatiu i conté l'exó alternatiu. A més a més, aquest trànscrit l'expressen les cèl.lules germinals . La proteïna SHBG/ABP humana es troba a nivell de l'acrosoma de les cèl.lules germinals durant tota la fase d'elongació de l'espermatogènesi, i a nivell de l'acrosoma dels espermatozous epididimaris.
2) Al càncer de pròstata s'ha treballat amb diferents linies cel.lulars de pròstata i amb mostres de pacients amb càncer de pròstata.
a) Linies cel.lulars de càncer de pròstata. S'ha treballat amb dues linies cel.lulars tumorals com són les PC3 i les LNCaP i dues linies cel.lulars normals com són les CAHVP10 i les PZHVP7. Les linies PC3 i LNCaP sobreexpressen 3 trànscrits que codifiquen per a la SHBG/ABP humana. El trànscrit majoritari dona lloc a la proteïna secretada, mentres que els dos trànscrits que falten els exons 6 i 6-7 respectivament, donen lloc a una proteïna intracel.lular. La diferència entre la linia PC3 (androgen-independent) i la linia LNCaP (androgen-depenent) és que la linia PC3 expressa la isoforma cx del receptor de estrògens beta.
b) Pacients afectats de càncer de pròstata. En 4 dels 6 pacients analitzats s'expressa la SHBG/ABP humana, en 3 d'ells s'expressa el receptor d'estrògens i en tots es sobreexpressa la P450 aromatasa.
La proteïna SHBG/ABP s'acumula a l'interior de les cèl.lules epitelials de les glandules tumorals en les seccions prostàtiques dels pacients analitzats.
The aim of this thesis is to study the alternative funcions of the sex hormone-binding globulin / androgen-binding protein (SHBG/ABP) during the espermatogenesis and prostate cancer.
1) In the study of the espermatogenesis we have used two different models: the transgenic mice overexpressing the rat SHBG/ABP, and the transgenic mice overexpressing the human SHBG/ABP.
a) Transgenic mice overexpressing rat SHBG/ABP. The overexpression of rat SHBG/ABP in the testis induces a parcial arrest of the first meiotic division and an increase of germ cell apoptosis, involving specifically primary spermatocytes and cells at metaphase. The apoptotic cells are overexpressing the mRNA and the protein for the estrogen receptor beta, and the protein acumalates in the citoplasm of this apoptotic cells.
b) Transgenic mice overexpressing human SHBG/ABP. The shbg11 mouse line overexpress the mRNA for the human SHBG/ABP in the testis, and this mRNA contains the alternative exon 1 (exon A). The human mRNA is expressed by germ cells, and the protein is located in the acrosome during all the elongation sattges of spermatogenesis.
2) In the sutdy of the prostate cancer we have used prostatic tumor cell lines (PC3 and LNCaP) and prostatic normal cell lines (CAHVP10 and PZHVP7) and samples from patients with prostate cancer.
a) Prostate cell lines. The tomurogenic cell lines PC3 and LNCaP overexpress three human SHBG/ABP transcripts, most abundant transcript produce secreted human SHBG/ABP protein. The other two transcripts lacking exon 6 and exon 6-7, produce intracelular human SHBG/ABP protein. The main difference between the PC3 cell line (androgen-independent) and the LNCaP cell line (androgen-dependent) is that PC3 cells are express the cx isoform of the estrogen receptor beta.
b) Patients with prostate cancer. Four of the six patients analized express human SHBG/ABP mRNA. Three of them co-express the estrogen receptor beta and all of them express the P450 aromatase.
The human SHBG/ABP protein is located in the epitelial cells from the tumoral glands in all the prostate sections analized from the patients with prostate cancer.
Forges, Thierry. "Etude de l'expression de la sex hormone-binding globulin (SHBG) dans les cellules de la granulosa humaines." Nancy 1, 2004. http://www.theses.fr/2004NAN11310.
Повний текст джерелаJasieczek, Christina Bozena. "Investigation of hydrogen bonding and SHG activity of organic salts and co-crystals." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318504.
Повний текст джерелаSchnitzbauer, Andreas. "Ligandbindungsstudien des humanen Steroidhormon-bindenden Globulins in einem Biosensorsystem." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974915815.
Повний текст джерелаBarlow, Emily J. "Ecological and genetic perspectives on dispersal in European shags (Phalacrocorax aristotelis)." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=182248.
Повний текст джерелаGranroth-Wilding, Hanna Maria Veronica. "Parasitism, family conflict and breeding success." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8243.
Повний текст джерелаLaurent, Guillaume. "Mélange d'ondes dans des nano-structures plasmoniques hybrides." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAY046/document.
Повний текст джерелаNonlinear nanophotonics offers a unique opportunity to open new path toward a wide range of pratical applications in sensors, quantum computers, cryptography devices. The main challenge is to enhance nonlinear response of nanosized particles in order to integrate them in optical components. On this purpose, we want to combine the electromagnetic field enhancement in metals (due to a phenomenon called plasmonic resonances) with non linear efficiency of non centrosymmetric nanocrystals.In this thesis, we present a numerical approach for simulating linear and non linear optical processes (second harmonic generation and spontaneous numerical down conversion) in hybrid nanostructures in order to “ tune “ plasmonic resonances and optimize light/matter coupling. The study predicts an enhancement by several orders of magnitude of the non linear phenomena modeled in composite nano particles
Limmer, Mark David. "I don't shag dirty girls : the impact of masculinity and social exclusion on young mens' sexual risk-taking." Thesis, Lancaster University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538581.
Повний текст джерелаSteel, William Hobbs. "Investigations of solvent polarity at liquid/liquid interfaces by SHG spectroscopy using molecular rulers." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1371.
Повний текст джерелаThesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Hohbach, Jan [Verfasser], Sascha [Gutachter] Flohé, and Bernd [Gutachter] Bittersohl. "Das Schwere SHT im Traumanetzwerk der DGU / Jan Hohbach ; Gutachter: Sascha Flohé, Bernd Bittersohl." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1190350750/34.
Повний текст джерелаDamianos, Dimitrios. "Génération de seconde harmonique (SHG) pour la caractérisation des interfaces entre diélectriques et semiconducteurs." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAT072/document.
Повний текст джерелаThis PhD work was developed in the context of research for novel characterization methods for ultra-thin dielectric films on semiconductors and their interfacial quality. Second harmonic generation (SHG) is a very promising non-invasive technique based on nonlinear optics. A laser emitting at the fundamental frequency is incident upon the sample which responds through its 2nd order polarization, generating a signal at twice the fundamental frequency. For centrosymmetric materials such as c-Si, amorphous SiO2 or Al2O3, the SHG signal is mainly due to the defects and to the static electric field Edc present at the interface (due to pre-existing charges Qox and/or photo-injected charge trapping/detrapping at interface traps Dit). Thus, SHG measurement gives access to the quality of dielectric/semiconductor interfaces. Nevertheless, the SHG signal is also dependent on multilayer optical propagation phenomena. For this reason, we have developed a simulation program which accounts for the optical phenomena and the static electric fields at the interfaces. We have used SHG to monitor the passivation quality of Al2O3/Si structures prepared with different processes and showed a correlation between SHG and minority carrier lifetime measurements. Qox and Dit were extracted from capacitance-voltage measurements and helped calculating the Edc values. The optical simulation, fed with known Edc values reproduced the experimental SHG data in these structures. The SHG was also used for Silicon-on-Insulator (SOI) substrates characterization. In thick SOI structures, both simulations and experimental results show that the SHG response is mainly given by optical interferences (Edc has no impact). In ultrathin SOI, the interfaces are electrically coupled and Edc is needed as input in the simulation in order to reproduce the experimental SHG data. This implies that in ultrathin SOI, SHG can access the interface electric fields in a non-destructive way
Sono, Tleyane J. "The study of surface SHG and polygonal microcavity design for nonlinear applications on LiNbO3." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/70939/.
Повний текст джерелаRossi, Giuliano. "Desenvolvimento de cavidade laser em 532nm para uso oftalmológico." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-17112009-085705/.
Повний текст джерелаThis work presents the research and the development of a solid state laser cavity with second harmonic generation for ophthalmological purpose. The laser cavity is part of a major project intended to produce a handle photocoagulator. This medical equipment is applied in several clinical protocols related to retinal and anterior chamber pathologies, such as diabetic retinopathy, retinopathy of prematurity, glaucoma, macular edema and retinal detachment. The present cavity is composed by three mirrors disposed in a V shape architecture. One laser diode pumps the Nd:YAG crystal to generate the 1064nm laser that is converted by second harmonic generation in 532nm through the KTP crystal (green laser). The coupling system attached in the cavity is able to collimate until 90% of the laser beam inside a optical fiber with 100 \'mü\'m core. The developed cavity produces a beam with wavelength of 532nm, spectral width of 0.5nm, maximum power around 2.5W in the end of the optical fiber and maximum pulse duration of 3s. Those parameters are requirements for ophthalmological treatments related to this kind of equipment. It is important to declare that the cavity was projected and developed in Brazil. This is the first work in this country that becomes effectively a device to clinical application. Besides the cavity design project, in this work also describes the mechanical and electronic sub systems that was responsible to the laser control and photocoagulator assembler. This product was tested in patients eyes from UNIFESP (Escola Paulista de Medicina), and showed similar results compared to the systems on the market.
Schick, Ariane [Verfasser]. "Einfluss von Steatosis hepatis, metabolischem Syndrom und weiteren Parametern auf den biologischen Serum-Marker Sexualhormonbindendes Globulin (SHBG) / Ariane Schick." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/105077163X/34.
Повний текст джерелаRoche, Didier. "Intérêts des dosages de l'IGF-1 et de la SHBG dans l'évaluation du statut nutritionnel de la personne âgée." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M221.
Повний текст джерелаGrira, Sarra Esling Claude. "Microstructure, texture et propriétés supraconductrices d'oxydes supraconducteurs haute température critique SHTc YBCO couches minces et NBCO and YBCO massifs /." Metz : Université de Metz, 2009. ftp://ftp.scd.univ-metz.fr/pub/Theses/2009/Grira.Sarra.SMZ0905.pdf.
Повний текст джерелаThèse soutenue en co-tutelle. Titre provenant de l'écran-titre. Notes bibliographiques. Index.
Gebhardt, Philipp [Verfasser], and Karl-Georg [Akademischer Betreuer] Kanz. "Kosten-Nutzenanalyse in der SHT (Schädel-Hirn-Trauma) - Diagnostik / Philipp Gebhardt. Betreuer: Karl-Georg Kanz." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1036095428/34.
Повний текст джерелаWheadon, C. J. D. (Christopher James Daniel), and n/a. "A systemic approach to understanding prehistoric shell-bearing deposits in New Zealand: a case study from Shag Point, North Otago." University of Otago. Department of Anthropology, 2002. http://adt.otago.ac.nz./public/adt-NZDU20070507.115526.
Повний текст джерелаThorsteinson, Nels. "Computational ligand discovery for the human and zebrafish sex hormone binding globulin." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/943.
Повний текст джерелаWilliamson, Patricia Catherine. "Squaraine dyes." Thesis, Cranfield University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323902.
Повний текст джерелаKassab, Diana. "Localisation du site de liaison des stéroïdes de la protéine plasmatique de transport des stéroïdes ("Sex Hormone-Binding Globulin", "SHBG") de lapin et de mouton par photomarquage d'affinité avec la Δ6-testostérone et étude du rôle du stéroïde dans la dimérisation de fragments recombinants de SHBG humaine". Lyon 1, 1998. http://www.theses.fr/1998LYO1T145.
Повний текст джерелаAït-Belkacem, Dora. "Microscopie polarimétrique du collagène de type I par génération de second harmonique dans des systèmes modèles et tissus." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30029.
Повний текст джерелаSecond harmonic generation (SHG) is a non-linear process which consists in coupling two photons at the same frequency to generate one photon at the twice frequency. It generally occurs in non-centrosymmetric samples such as crystals or molecular assemblies. The manipulation of the optical field polarization gives access to structural and microscopic informations. Moreover, using polarized detection allows to determine physical effects in molecular assemblies.In this Phd thesis, we are particulary interested in studying polarized SHG signals from collagen type I fibers in model samples and tissues. We extend our work to the investigation of the interaction of the fibers with their cellular environment. We also address the problematic of cancerous tissues.Finally, we propose several models for the microscopic structure of collagen, evaluated by a method based on the Fourier decomposition of the polarized SHG signal, to provide a quantitative diagnosis of biological samples
Santos, Moisés Oliveira dos. "Ablação de pele queimada com laser de pulsos ultra-curtos para promoção da cicatrização. Avaliação por tomografia por coerência óptica, histologia, μATR-FTIR e microscopia não-linear." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-08032013-135443/.
Повний текст джерелаBurns cause changes in the anatomical structure of the skin associated with trauma. The severity of the burn injury is divided into first, second and third-degree burns. The third-degree burns have been a major focus of research in search of more conservative treatments and faster results in repair for a functional and cosmetically acceptable. The conventional treatment is the use of topical natural or synthetic skin graft. An alternative therapy is the laser ablation process for burned tissue necrosis removal due to the no mechanical contact, fast application and access to difficult areas. The purpose of this study is to evaluate the feasibility of using high intensity femtosecond lasers as an adjunct treatment of burned patients. For this study, 65 Wistar rats were divided into groups of five animals: healthy skin, burned skin, two types of treatment (surgical debridement or femtosecond laser ablation) and four different times in the healing process monitoring. Three regions of the back of the animals were exposed to steam source causing third-degree burn. On the third day after the burn, one of the regions was ablated with high intensity ultrashort laser pulses (λ = 785 nm, 90 fs, 2 kHz and 10 μJ/ pulse), the other received surgical debridement, and the last was considered the burn control. The regions were analyzed by optical coherence tomography (OCT), histology, attenuated total reflectance infrared spectroscopy using Fourier transform (μ-ATR-FTIR), two-photon excitation fluorescence microscopy (TPEFM) and second harmonic generation technique (SHG) on days 3, 5, 7 and 14 pos-treatments. The results showed that with the laser irradiation conditions used it was possible to remove debris from third degree burn. The techniques used to characterize the tissue allowed to verify that all treatments promoted wound healing. On the fourteenth day, the regeneration curve showed that the attenuation coefficient of laser ablated tissue converges to the values of healthy skin, but collagen fibers have not yet reached the same organization of those in the healthy skin