Дисертації з теми "Shin module"
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Salerno, Benjamin D. "Controller design, analysis, and prototype for ship service converter module." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1996. http://handle.dtic.mil/100.2/ADA313846.
Повний текст джерелаGray, Weston L. "DC to DC power conversion module for the all-electric ship." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68166.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 91-92).
The MIT end to end electric ship model is being developed to study competing electric ship designs. This project produced a model of a Power Conversion Module (PCM)- 4, DC-to-DC converter which interfaces with the MIT model. The focus was on the Medium Voltage DC (MVDC) architecture, and therefore, the PCM-4 converts a MVDC bus voltage of 3.3, 6.5 or 10 kVDC to 1 kVDC. The design describes the transient and steady-state behavior, and investigates the naval architecture characteristics. A modular architecture, similar to SatCon Applied Technology's Modular Expandable Power Converters, was selected as the best balance for the wide variation in loads experienced. The model consists of a standard module that can be paralleled internally to provide for a wide range of system power requirements. Naval architecture parameters, such as weight, volume, efficiency, and heat load, were compiled into a parametric format allowing a reasonable approximation of actual weight and volume as a function of rating and efficiency and heat load as a function of loading. All of the parameters were evaluated for dependence on the MVDC bus voltage. Verification of the model was pursued through comparison to available simulations of similar power electronics to ensure that the model provided reasonable time response and shape. Finally, the model met all requirements with the exception of efficiency which was slightly lower than the requirement although several ideas were presented to improve efficiency.
by Weston L. Gray.
S.M.
Nav.E.
Barnum, Usher L. "Business process re-engineering: application for littoral combat ship mission module acquisition." Monterey, California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/10121.
Повний текст джерелаThe purpose of this MBA Project is to investigate the possibility/feasibility of re-engineering the Littoral Combat Ship Mission Module (PMS-420) business process to function more efficiently. The Defense Acquisition system is designed to support the National Security Strategy by managing the technologies and programs that produce weapons system for the United States Armed Forces. Although the overall acquisition system functions well as designed, the purpose of this paper is to investigate the business process within PMS-420, and whether another design is more efficient. This paper will review the genesis of PEO LMW and its basic functionality as well as discuss in detail the unique business process of PMS-420 and its varied inter-agency relationships. This paper will discuss the efficient business processes of two other acquisition programs within PEO LMW; 1) Naval Special Warfare (PMS-340) and 2) Explosive Ordnance Disposal (PMS-408). While discussing these other acquisition programs this paper will note the particular business processes and management policies that promote efficiency, and whether these attributes can be applied to PMS-420. The final portion of this paper will be a summary of the findings and recommendations to PMS 420 in order for it to function more efficiently.
Ault, William R. "Design and implementation of an operations module for the ARGOS paperless ship system." Thesis, Monterey, California. Naval Postgraduate School, 1989. http://hdl.handle.net/10945/26969.
Повний текст джерелаThe "paperless' ship is an idea wvhich has been advocated at the highest levels in the Navy. The goal is to eliminate the enormous amount of paper required in the normal operation of a modern naval warship. The ARGOS system under development at the Naval Postgraduate school is a prototype solution which uses HyperCard/HyperTalk for prototype development. The operations functional area, including sections for training, scheduling, message generation, and publication management is an important part of this development.
http://archive.org/details/designimplementa00ault
Руденко, Павло Андрійович. "Технологічне забезпечення токарного оброблення деталей складної конструкції". Master's thesis, КПІ ім. Ігоря Сікорського, 2019. https://ela.kpi.ua/handle/123456789/30836.
Повний текст джерелаStructure and scope of work. The master's thesis includes an introduction, 4 sections, general conclusions, a list of used literature. The work consists of 96 pages of text, 21 tables, 43 drawings and 10 literary sources. Actuality of theme. For modern production, one of the most important aspects is the time of machining of parts, because this direction has an impact on the economic component. For the manufacturing of components for lower limb prostheses, time is the main problem because parts are sold through a tender that has certain time limits for execution. Therefore, the author had to provide recommendations for reducing operating time by 20%. The purpose and objectives of the study. To analyze the existing method of manufacturing a part of complex construction "Hull". Analyze and provide recommendations for the modernization of the technological process through the use of modern technological equipment. Investigate, optimize, and deploy new production tools. The object of study - is the technological process of manufacturing the module of the shin of the adjustable-connecting node, which has a complex design. The subject of the study- is the reduction of operating time for the manufacture of one part. Research methods: familiarization and analysis of the technological process, investigation of the problems of the technological system used, analysis of the catalogs of leading equipment manufacturing companies to obtain complete information on the use of modern technologies, the study of equipment operating modes to be able to make optimization recommendations. Scientific novelty of the obtained results: 1. Investigation of the recommended operating modes of technological equipment on the example of a working production, optimization of these modes and establishment of an error for its further use when introducing new equipment. 2. Development of a universal method for determining the coordinates of the axis of the cutting tool when using gearboxes with a rotating angle of the spindle axis and its implementation in real production. The practical significance of the results obtained. The obtained results were implemented at the production of the enterprise of DO"Impulse" Co., Ltd and are fully used in the working process. There is a production certificate on which the results of work are implemented. A copy of the experimental study is also available to confirm the workability of the results.
Структура и объем работы. В магистерскую диссертацию входить введение, 4 главы, выводы, список использованной литературы. Работа состоит из 96 страниц текста, 21 таблиц, 43 рисунков и 10 литературных источников. Актуальность темы. Для современного производства одним из важнейших аспектов есть время обработки деталей, потому что это напрямую влияет на экономическую составляющию. Для производства которое производит составляющие для протезов нижних конечностей, время является самой главной проблемою из-за того, что реализация деталей происходит за счет проведения тендера у которого есть определенные сроки времени на выполнение. Поэтому автору необходимо было предоставить рекомендации для сокращения операционного времени на 20%. Цель и задачи исследования. Проанализировать имеющийся метод изготовления детали сложной конструкции «Корпус». Проанализировать и предоставить рекомендации по модернизации технологического процесса за счет использование современного технологического оборудования. Иследовать, оптимизировать, и внедрить в работу новые средства производства. Объект исследования - технологический процесс изготовления модуля голени регулировано-соединительного узла который имеет слжную конструкцию. Предмет исследования - сокращение операционного времени для изготовления одной детали. Методы исследования: Ознакомление и анализ технологического процесса, исследования возникновение проблем технологической системы которая используется, анализ каталогов ведущих компаний по производству оснастки для получение полной информации использование современных технологий, исследования режимов работы оборудования для возможности сделать рекомендации по оптимизации. Научная новизна полученных результатов: 1. Исследование рекомендованных режимов работы технологического оборудования на примере работающего производства, оптимизация этих режимов и установления погрешности для дальнейшего ее использование при внедрении нового оснащения. 2. Разработка универсального метода определения координат оси инструмента во время использование редукторов с поворотным углом оси шпинделя и его внедрение в условиях реального производства. Практическое значение полученных результатов. Полученные результаты были внедрены на производстве предприятия ООО «КБ« Импульс »и в полную меру используются в рабочем процессе. В наличии есть справка от производства на котором внедрены результаты работы. Также в наличии имеется экземпляр экспериментального исследования для подтверждения работоспособности результатов.
Stallings, Brad L. "Design of a ship service converter module for a reduced-scale prototype integrated power system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2001. http://handle.dtic.navy.mil/100.2/ADA392078.
Повний текст джерелаThesis advisor(s): Ciezki, John G. ; Ashton, Robert W. "December 2001." Includes bibliographical references (p. 201-202). Also available in print.
Wilson, Stephen K. "The mathematics of ship slamming." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:7bc325cf-e6a1-45d2-add2-100d9968354c.
Повний текст джерелаObisesan, Abayomi. "Stochastic damage modelling of ship collisions." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231845.
Повний текст джерелаMelvin, James E. "AUV fault detection using model based observer residuals." Thesis, Monterey, Calif. : Naval Postgraduate School, 1998. http://bosun.nps.edu/uhtbin/hyperion-image.exe/NPS-ME-98-004.pdf.
Повний текст джерелаTitle from cover. Thesis advisor(s): Anthony J. Healey. "June 1998."--Cover. "NPS-ME-98-004"--Cover. Includes bibliographical references (p. 117-118). Also available online.
繆泉明 and Quanming Miao. "Effect of submerged vertical structures on ship waves." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3025176X.
Повний текст джерелаGong, Qi, and 龔綺. "Gerber-Shiu function in threshold insurance risk models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40987966.
Повний текст джерелаSaavedra, Cayan Atreio Portela Bárcena. "Um aplicativo shiny para modelos lineares generalizados." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/11/11134/tde-22012019-174209/.
Повний текст джерелаRecent technological and computational advances have brought alternatives that have led to changes in the way data analyzes and visualizations are done. One of these changes is characterized by the use of interactive platforms and dynamic graphics to carry out such analyzes. In this way, data analyzes and visualizations are no longer limited to a static environment, so exploring this dynamic interactivity can enable a wider range of data exploration and presentation. The present work aims to propose an interactive application, easy to use and with user-friendly interface, which enables studies and descriptive analysis and fit generalized linear models. This application is made using the shiny package in the R environment of statistical computing. The purpose of the application is to act as a support tool for statistical research and teaching. Users with no familiarity in programming can explore the data and perform the fit of generalized linear models without typing a single code line. Regarding teaching, the dynamics and interactivity of the application gives the student an uncomplicated way to investigate the methods involved, making it easier to assimilate concepts related to the subject.
Jacobson, Kevin Robert. "The Littoral Combat Ship (LCS) Surface Warfare (SUW) module determining the best mix of surface-to-surface and air-to-surface missiles." Thesis, Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/5207.
Повний текст джерелаAsymmetric threats pose increasing challenges to the United States Navy in littoral environments. To address the Navy's need for a new platform to serve in this area, the Littoral Combat Ship (LCS) was designed and put into service. What still has yet to be determined is what surface-to-surface capability the LCS will have as well as what air-tosurface capability the LCS helicopter/unmanned aerial vehicle (UAV) will have. This study uses freely available data to build a simulation utilizing an agent-based modeling platform known as MANA. The simulation is exercised over a broad range of different weapon systems types with their capabilities ranged across the spectrum of possibilities based on their effectiveness as well as potential difficulties in targeting small boat threats. Using linear regression and partition trees, an analysis is performed on the resulting dataset to address the research question. The results show that the NLOS system is the best surface-to-surface missile system for the LCS as long as the expected rate of fire is obtained. The best air-tosurface missile system is either APKWS or LOGIR, depending on which can obtain a rate of fire of one missile every nine seconds or faster. Lastly, the rate of fire has been shown to be the most important factor in determining the effectiveness of the different missiles.
Gutierrez, Louis Michael. "Agent-based simulation of disease spread aboard ship." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Mar%5FGutierrez.pdf.
Повний текст джерелаThesis Advisor(s): Chris Darken. Includes bibliographical references (p. 47-48). Also available online.
Eigelaar, Lerika Susan. "Scale model validation of QUAYSIM and WAVESCAT numerical models of ship motions." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96758.
Повний текст джерелаENGLISH ABSTRACT: Various numerical modelling software packages are available for predicting moored ship motions and forces. The focus of this study was to validate the numerical models QUAYSIM and WAVESCAT and how these models together form a procedure for predicting moored ship motions and forces under the impact of high and low frequency waves. The validation procedure applied in the study involved numerical modelling of a given physical model situation in which moored ship motions and forces were measured under both high and low frequency wave conditions. A physical model with built-in bathymetry was provided by the Council for Scientific and Industrial Research (CSIR) Hydraulics Laboratory in Stellenbosch. The model consisted of a moored container vessel at a jetty, with various mooring lines and fenders. A JONSWAP spectrum, which combines high and low frequency wave components, was used to simulate wave conditions for the modelling of ship motions. The wave periods and wave heights were measured at observation stations located at specific points in the basin. Other measurements such as those of the forces in the fenders and mooring lines were also determined. A multi-step approach was used to numerically predict the ship motions and forces. Firstly, the coastal processes occurring within the basin, which was set up to simulate the physical model wave behaviour, were measured to calibrate the SWAN Delft3D-WAVE model. The wave heights and periods for the respective observation stations were obtained and compared to the physical model measurements. The Delft3D-FLOW SURFBEAT model was used to calculate the low frequency waves in the coastal area. Low frequency waves are the main cause of larger ship motions and forces, therefore it is important to investigate them as part of the ship motion prediction procedure. After the waves had been computed, wave forces acting on the vessel needed to be determined for both high and low frequency waves. These wave forces were modelled with the combinations SURFBEAT/LF-STRIP (low frequency waves) and SWAN/WAVESCAT (high frequency waves). LF-STRIP provided the link between low frequency wave models and ship motion models, converting the low frequency waves into long wave forces acting on the vessel. WAVESCAT converted the high frequency waves to short wave forces. The calculated long wave forces and short wave forces served as the input required to run the ship motion model QUAYSIM to determine the movements of the moored ship as well as the restraining forces in the lines and fenders. The ship motions and forces were compared to the physical model, with the intention of possibly validating the QUAYSIM/WAVESCAT approach for predicting moored ship motions. The study provides an overview of both the setup and results of the physical and numerical model. A description of each of the numerical models SWAN, SURFBEAT, LF-STRIP, WAVESCAT and QUAYSIM is provided, along with a comparison between the physical and numerical models for each procedure. The validation procedure provided useful documentation of the quality of these numerical modelling approaches, already in use in some design projects. The numerical models WAVESCAT and QUAYSIM models of ship motion have shown to provide a good correlation between the physical model and the numerical approach. However, improvements are still required. Good comparisons were obtained for the long wave motions (horizontal movements - surge, sway and yaw). The surge and sway motions were slightly overestimated by QUAYSIM. The magnitude of the yaw was comparable but the not well represented in spectral plots.
AFRIKAANSE OPSOMMING: Daar is verskeie numeriese modellering-sagtewareprogramme beskikbaar waarmee skipbewegings en -kragte voorspel kan word. Die fokus van hierdie studie was om die numeriese modelle QUAYSIM en WAVESCAT te valideer. Saam vorm hierdie twee modelle ’n prosedure om vasgemeerde skipbewegings en -kragte veroorsaak deur lang- en kortgolfaksie te bepaal. Die validasieprosedure wat in hierdie studie gebruik is, behels ’n numeriese modelering van ’n fisiese situasie waar ’n vasgemeerde skip se bewegings en kragte onder kort- en langgolfkondisies gemeet is. ’n Fisiese model met ingeboude batimetrie is voorsien deur die Council for Scientific and Industrial Research (CSIR) se hidroliese laboratorium in Stellenbosch. Die model bestaan uit ’n vasgemeerde houerskip by ’n pier met verskeie ankerlyne en bootbuffers. ’n JONSWAPspektrum, wat kort- en langgolfkomponente kombineer, is gebruik om golfomstandighede vir die modellering van skipbewegings te simuleer. Golfperiodes en golfhoogtes is by spesifieke waarnemingstasies in die gesimuleerde hawe-area gemeet. Verdere opmetings, soos dié van die kragte in die bootbuffers en ankerlyne, is ook gedoen. ’n Stap-vir-stap benadering is gevolg om die skipbewegings numeries te voorspel. Eerstens is die kusprosesse wat in die gesimuleerde hawe plaasvind, gekalibreer met die numeriese paket SWAN Delft3D-WAVE. Die golfhoogtes en golfperiodes vir elke waarnemingstasie is bereken en vergelyk met die fisiese model se opmetings. Die SURFBEAT-module van Delft3D-FLOW is gebruik om die lae-frekwensie golwe in die kusarea te bereken. Lae-frekwensie golwe is die hoofoorsaak van skipbewegings en daarom is dit belangrik om dit te ondersoek gedurende die voorspellingsprosedure van skipbewegings. Na die golwe bereken is, moes die kragte wat beide kort en lang golwe op die skip uitoefen ook bereken word. Hierdie golfkragte is gemodelleer deur middel van die kombinasies SURFBEAT/LFSTRIP (langgolwe) en SWAN/WAVESCAT (kortgolwe). LF-STRIP het die skakel tussen golfmodelle en skipbewegingsmodelle verskaf en die lae-frekwensie golwe omgeskakel in langgolfkragte wat op die skip uitgeoefen is. WAVESCAT het die hoë-frekwensiegolwe omgeskakel in kortgolfkragte wat op die skip uitgeoefen is. Die berekende langgolf- en kortgolfkragte is ingevoer op die skipbewegingsmodel QUAYSIM om die skipbewegings en inperkingskragte in die bootbuffers en ankerlyne te bepaal sodat dit vergelyk kon word met die fisiese model, met die doel om moontlik die QUAYSIM/WAVESCAT-prosedure om gemeerde skipbewegings te voorspel te valideer. Die studie verskaf ’n oorsig van die opstel en resultate van die fisiese en numeriese modelle. Elk van die numeriese modelle SWAN, SURFBEAT, LF-STRIP, WAVESCAT en QUAYSIM word beskryf en vergelykings word getref tussen die numeriese en fisiese modelle vir elke prosedure. Die validasieprosedure verskaf nuttige dokumentasie van die kwaliteit van hierdie numeriese modeleringsprosedures wat reeds in sekere ontwerpprojekte gebruik word. Die numeriese WAVESCAT en QUAYSIM modelle van skipbewegings het ’n goeie korrelasie tussen die fisiese model en die numeriese benadering gelewer. Verbeteringe is wel steeds nodig. Goeie vergelykings is verkry vir langgolfbewegings (horisontale bewegings – stuwing (“surge”), swaai (“sway”) en gier (“yaw”)). Die stu- en swaaibewegings was effens oorskat met QUAYSIM. Die grootte van die gier was wel vergelykbaar maar is nie grafies goed uitgebeeld nie.
Rhoades, Mark M. "A study of the airwake aerodynamics over the flight deck of an AOR model ship." Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA241008.
Повний текст джерелаThesis Advisor(s): Healey, J. Val. Second Reader: Schmidt, L. V. "September 1990." Description based on title screen as viewed on December 18, 2009. DTIC Descriptor(s): Velocity, Air Flow, Flight Decks, Shear Properties, Measurement, Position(Location), Ships, Models, Layers, Edges, Boundary Layer, Flow Visualization, Tunnels, Curvature, Smoke, Stationary, Bubbles, Patterns, Helium, Flow, Ship Models, Video Signals, Anemometers, Earth Atmosphere, Deflectors, Photographic Equipment. DTIC Identifier(s): Wake, Naval Vessels(Support), Turbulence, Helicopters, Atmospheric Motion, Air Flow, Ship Models, Replenishment at sea, AOR Class Vessels, H-56 Aircraft, Wind Direction, Oilers(Naval Vessels), Rotor Blates(Rotary Wings), Impact, Vertical Replenishment, Blade Strike, Theses, Wind Tunnel Models. Author(s) subject terms: Flow Visualization, Simulated Atmospheric Boundary Layer, Helium Bubble Flow Visualization, Smoke Visualization, AOR Class ship. Includes bibliographical references (p. 84-85). Also available in print.
Baeza, Fernández Damian Francisco. "Diseño y simulación de un sistema para el control del estado metabolico de células animales en cultivo." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/111533.
Повний текст джерелаIngeniero Civil Químico
Resultados experimentales señalan que las células animales pueden alcanzar múltiples estados metabólicos con distintas razones de tasa de producción de lactato a tasa de consumo de glucosa (DL=DG), lográndose razones muy por debajo de la razón estequiométrica igual a 2 [mol=mol]. En el presente trabajo de tesis se planteó y ajustó un modelo metabólico que describe el metabolismo de un cultivo de control y se corroboró su falta de capacidad de alcanzar más de un estado estacionario a través de la comparación con datos experimentales y un análisis de estabilidad posterior. La simplificación de dicho modelo inicial, la obtención de un único punto atractor como estado estacionario y el análisis de variaciones de niveles de expresión génica de ciertas enzimas glicolíticas permitió el planteamiento de un modelo de regulación que varía la concentración de la enzima lactato deshidrogenasa (LDH) con el cual se simuló un cultivo hasta alcanzar estado metabólico alterado (DL=DG <0,1 [mol=mol]). El modelo metabólico regulado se utilizó para la simulación de un cultivo continuo alterado para el diseño y ajuste de controladores proporcional (P), basado en modelo lineal y basado en modelo no lineal para la regulación de la concentración de glucosa de entrada frente a perturbaciones en el crecimiento celular. La simulación de la respuesta de lazo cerrado del sistema mostró una fuerte interacción de lazos con el lazo de control de crecimiento celular y los análisis de robustez y de sensibilidad permitieron concluir que el controlador P posee una mayor robustez que el controlador basado en modelo lineal, pero que este último posee una mejor respuesta frente a limitantes que podrían existir a nivel industrial. Por otra parte, el pobre desempeño del controlador basado en modelo no lineal demuestra un desafío de ajuste del mismo producto de las múltiples posibles fuentes del mal desempeño. Como línea de trabajo futuro se puede mejorar la respuesta simulada de los controladores basados en modelo, analizando la eliminación de offset para el caso lineal y los problemas de rendimiento del basado en modelo no lineal.
Zhang, Lu. "Lecture sémiotique du Sou shen ji de Gan Bao : modèles théoriques et interprétations du discours." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPC0018/document.
Повний текст джерелаSou shen ji is the most representative and influential work of the zhiguai genre, its historic and artistic value is unmatchable, compaired with other works of the same genre. The author, Gan Bao, is a very famous historian and scholar in Dong Jin dynasty. Among his numerous historical and literary works, it is Sou shen ji, who has had the biggest success. This work collects around four hundred and sixty-four stories independent one from each other, and the subjects are also very various, reflecting to some extent the mentality and the beliefs of the Chinese of the time. In this thesis, we have studied this work in a semiotic perspective, using the semiotic theory of Greimas. In the discursive part, we have done some analyses, from a discoursive and a cultural point of view, of the chinese conception of shen, from four categories : the gods who have a function (shen神), the immortals (xian仙), the ghosts (gui鬼), and the yaoguai妖怪, in order to draw a clearer picture of the conception of shen to the chinese. We can see that in the chinese culture, the conception of shen, located at the intersection of the religion, the politics, and the ethics, is not a concept defined in theological and transcendental termes. In the narrative part, we focus on the narrative features of the stories in Sou shen ji, and at the same time, we also try to build a narrative model which is more applicable to these stories and to the description of the intersubjective relationship
NEILDEZ, OLIVIER. "Etude de la transmission sexuelle du vih dans le modele du macaque infecte experimentalement par le siv ou un virus chimere shiv." Paris 7, 1999. http://www.theses.fr/1999PA077182.
Повний текст джерелаTian, Lu. "Isolement et caractérisation de cellules souches cancéreuses dans un modèle murin de tumorigénèse mammaire." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S001/document.
Повний текст джерелаBreast cancer is the most common cancer in women worldwide. The isolation and characterization of breast cancer stem cells (CSC) are crucial for understanding cancer biology and revealing potential therapeutic targets. One of the major issues in the study of CSC is the lack of reliable markers. A transgenic mouse model (Tg 11.5kb–GFP) was generated using the 11.5kb s-SHIP (stem-SH2-containing 5’-Inositol Phosphatase) promoter that specifically expressed enhanced green fluorescent protein (GFP) in embryonic and various tissue stem cells. In the mammary gland, previous experiments showed that GFP labels puberty cap cells and pregnancy basal alveolar bud cells, and it has been demonstrated that these mammary GFP+ cells are activated tissue stem cells. In order to determine if s-SHIP promoter expression could also mark mammary cancer stem cells, we generated a bi-transgenic mouse model by crossing Tg 11.5kb-GFP mice with Tg C3(1)/Tag mice. Tg C3(1)/Tag mice express SV40 T antigen under the regulatory control of the rat prostatic steroid binding protein C3(1) gene. In female mice, the transgene is expressed primarily in the mammary gland. Mice develop mammary hyperplasia by 3 months of age with subsequent development of mammary adenocarcinoma by 6 months of age.Here we show the presence of a rare population of GFP+ cells, which are also CD24+/CD49f+/CD29+ in mammary tumors of female bi-transgenic mice. As compared to GFP- cells, GFP+ cells exhibit both a higher tumor sphere-forming potential, and a higher tumorigenicity when transplanted into SCID and FVB recipient mice. Moreover, upon subsequent transplantation, the GFP+ cells generated heterogeneous tumors that displayed properties similar to the primary tumor. Transcriptomic analysis of these GFP+ vs GFP- cells revealed several differentially expressed genes including one protein implicated in the Notch pathway. In addition, from the murine mammary tumor, I have derived a cell line containing a s-SHIP/GFP+ subpopulation that shows resistance to chemotherapy and radiation. I have further studied this subpopulation and found that synuclein gamma could confer radiation resistance to breast cancer cells. Altogether, these results demonstrate that s-SHIP promoter expression is a marker of mammary CSC that enables their identification and isolation via a single consistent parameter
Hittel, Steven George. "An experimental analysis of the hydrodynamic characteristics of the monoform: a novel hull form." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/91119.
Повний текст джерелаM.S.
Goodman, William K. Infante Isaia Benette E. Rodriguez Roland G. "Item Unique Identification (IUID) marking for a littoral combat ship (LCS) class mission module (MM) at the mission package support facility (MPSF) implementation analysis and development of optimal marking procedures /." Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/MBAPR/2010/Jun/10Jun%5FGoodman%5FMBA.pdf.
Повний текст джерелаAdvisor(s): Ferrer, Geraldo ; Brinkley, Douglas. "June 2010." "MBA Professional report"--Cover. Description based on title screen as viewed on July 14, 2010. Author(s) subject terms: Item Unique Identification, Littoral Combat Ship, Mission Package Support Facility, Unique Identification, Unique Item Identifier Includes bibliographical references (p. 83-87). Also available in print.
Goodman, William K., Roland G. Rodriguez, and Isaia Benette E. Infante. "Item Unique Identification (IUID) marking for a littoral combat ship (LCS) class mission module (MM) at the mission package support facility (MPSF): implementation analysis and development of optimal marking procedures." Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/10524.
Повний текст джерелаThe purpose of this MBA project is to implement an effective solution to the DoD's mandatory January 2004 IUID policy for LCS MPs at the Port Hueneme MPSF. Our methodology was to analyze the item marking process to determine the optimal marking procedure for items that bypassed the MPSF. Logical Decisionsᆰ for Windows was utilized to determine the best course of action with regard to cost, crew burden, compliance achievement, and reduced mistakes. It was determined that, among five possible courses of action, waiting for a maintenance availability was the optimal solution.
Irwin, Shaun George. "Optimal estimation and sensor selection for autonomous landing of a helicopter on a ship deck." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95894.
Повний текст джерелаENGLISH ABSTRACT: This thesis presents a complete state estimation framework for landing an unmanned helicopter on a ship deck. In order to design and simulate an optimal state estimator, realistic sensor models are required. Selected inertial, absolute and relative sensors are modeled based on extensive data analysis. The short-listed relative sensors include monocular vision, stereo vision and laser-based sensors. A state estimation framework is developed to fuse available helicopter estimates, ship estimates and relative measurements. The estimation structure is shown to be both optimal, as it minimises variance on the estimates, and flexible, as it allows for varying degrees of ship deck instrumentation. Deck instrumentation permitted ranges from a fully instrumented deck, equipped with an inertial measurement unit and differential GPS, to a completely uninstrumented ship deck. Optimal estimates of all helicopter, relative and ship states necessary for the autonomous landing on the ship deck are provided by the estimator. Active gyro bias estimation is incorporated into the helicopter’s attitude estimator. In addition, the process and measurement noise covariance matrices are derived from sensor noise analysis, rather than conventional tuning methods. A full performance analysis of the estimator is then conducted. The optimal relative sensor combination is determined through Monte Carlo simulation. Results show that the choice of sensors is primarily dependent on the desired hover height during the ship motion prediction stage. For a low hover height, monocular vision is sufficient. For greater altitudes, a combination of monocular vision and a scanning laser beam greatly improves relative and ship state estimation. A communication link between helicopter and ship is not required for landing, but is advised for added accuracy. The estimator is implemented on a microprocessor running real-time Linux. The successful performance of the system is demonstrated through hardware-in-the-loop and actual flight testing.
AFRIKAANSE OPSOMMING: Hierdie tesis bied ’n volledige sensorfusie- en posisieskattingstruktuur om ’n onbemande helikopter op ’n skeepsdek te laat land. Die ontwerp van ’n optimale posisieskatter vereis die ontwikkeling van realistiese sensormodelle ten einde die skatter akkuraat te simuleer. Die gekose inersie-, absolute en relatiewe sensors in hierdie tesis is op grond van uitvoerige dataontleding getipeer, wat eenoogvisie-, stereovisieen lasergegronde sensors ingesluit het. ’n Innoverende raamwerk vir die skatting van relatiewe en skeepsposisie is ontwikkel om die beskikbare helikopterskattings, skeepskattings en relatiewe metings te kombineer. Die skattingstruktuur blyk optimaal te wees in die beperking van skattingsvariansie, en is terselfdertyd buigsaam aangesien dit vir wisselende mates van skeepsdekinstrumentasie voorsiening maak. Die toegelate vlakke van dekinstrumentasie wissel van ’n volledig geïnstrumenteerde dek wat met ’n inersiemetingseenheid en ’n differensiële globale posisioneringstelsel (GPS) toegerus is, tot ’n algeheel ongeïnstrumenteerde dek. Die skatter voorsien optimale skattings van alle vereiste helikopter-, relatiewe en skeepsposisies vir die doeleinde van outonome landing op die skeepsdek. Aktiewe giro-sydige skatting is by die posisieskatter van die helikopter ingesluit. Die proses- en metingsmatrikse vir geruiskovariansie in die helikopterskatter is met behulp van ’n ontleding van sensorgeruis, eerder as gebruiklike instemmingsmetodes, afgelei. ’n Volledige werkingsontleding is daarna op die skatter uitgevoer. Die optimale relatiewe sensorkombinasie vir landing op ’n skeepsdek is met Monte Carlo-simulasie bepaal. Die resultate toon dat die keuse van sensors hoofsaaklik van die gewenste sweefhanghoogte gedurende die voorspellingstadium van skeepsbeweging afhang. Vir ’n lae sweefhanghoogte is eenoogvisie-sensors voldoende. Vir hoër hoogtes het ’n kombinasie van eenoogvisie-sensors en ’n aftaslaserbundel ’n groot verbetering in relatiewe en skeepsposisieskatting teweeggebring. ’n Kommunikasieskakel tussen helikopter en skip is nie ’n vereiste vir landing nie, maar word wel aanbeveel vir ekstra akkuraatheid. Die skatter is op ’n mikroverwerker met intydse Linux in werking gestel. Die suksesvolle werking van die stelsel is deur middel van hardeware-geïntegreerde simulasie en werklike vlugtoetse aangetoon.
Kreider, Marc Alan. "A numerical investigation of the global stability of ship roll : invariant manifolds, Melnikov's method, and transient basins /." Thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-03142009-040740/.
Повний текст джерелаSwahn, Inger, and Anneli Forsum. "Sjuksköterskors uppfattning om omvårdnadshandledning." Thesis, Jönköping University, HHJ, Dep. of Nursing Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-1672.
Повний текст джерелаHandledaren är en nyckelperson i studenternas utveckling till professionella sjuksköterskor. Syftet med denna studie var att undersöka och beskriva sjuksköterskors uppfattning om omvårdnadshandledning av sjuksköterskestudenter. Fokusgruppsintervjuer valdes som metod. Nitton sjuksköterskor deltog i intervjuerna. Materialet bearbetades. Två huvudkategorier formulerades: Egenskaper och Kompetens med ett övergripande tema: Handledningens kvalitet. I resultatet av intervjuerna framkom faktorer som har betydelse för en god handledning och utveckling av handledarrollen: handledarens- studentens och organisationens egenskaper samt pedagogisk- yrkes och social kompetens. Det framkom att viktiga kvaliteter både hos handledare och student är intresse och motivation samt ett gemensamt ansvar för studenternas lärande. Det efterfrågas faktorer som tid och acceptans för handledning från organisationen. En professionell sjuksköterska som är en bra förebild för studenten och har en god pedagogisk kompetens är bra handledare. För att kunna utvecklas i sin handledarroll efterlyser sjuksköterskorna feedback från sina studenter. Uppfattningen var att det är roligt att vara handledare och att det är en tillfredsställelse att lyckas föra en människa framåt i sitt lärande.
The preceptor is a key person in the students development to professional nurses. The purpose with this study was to examine and describe how nurses thinking of the preceptor ship for nurse students. Focus group interviews were chosen as method. Nineteen nurses participated in the interviews. The interviews were analysed. Two main categories were developed: Characteristics and Competence with a comprehensive theme regarding the nurses understanding of the quality of preceptor ship. The result of interviews showed factors of significance for the quality and development of the preceptor ship role: the preceptor, students and the organisations characteristics as well as pedagogical, professional and social competence. It was made clear that the interest and motivation as well as a mutual responsibility for the students learning is important qualities for both the preceptor and the student. Preceptors requested factors such as time and acceptance for preceptor ship from the organisation. A good preceptor is a professional nurse that is a good model for students and has a well developed pedagogical competence. To be able to develop one’s role as a preceptor, nurses are making inquiries about feedback from their students. The opinion of the preceptors was that it is amusing to be a preceptor and that it is satisfactory to succeed in leading a human forward in her development.
Teichman, Jason A. "Automated Sea State Classification from Parameterization of Survey Observations and Wave-Generated Displacement Data." ScholarWorks@UNO, 2016. http://scholarworks.uno.edu/td/2199.
Повний текст джерелаAgarwal, Richa. "Network design and alliance formation for liner shipping." Diss., Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-07082007-213229/.
Повний текст джерелаProfessor Michael D. Meyer, Committee Member ; Professor Ozlem Ergun, Committee Chair ; Professor Ellis Johnson, Committee Member ; Professor George L. Nemhauser, Committee Member ; Professor H. Venkateswaran, Committee Member.
Linde, Florian. "3D modelling of ship resistance in restricted waterways and application to an inland eco-driving prototype." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2389/document.
Повний текст джерелаAn eco-driving prototype, named EcoNav, is developed with the aim of optimizing a vessel speed in order to reduce fuel consumption for a given itinerary. EcoNav is organized in several modules : - a 2D hydraulic model simulating the flow conditions (current speed and water depth) along the itinerary; - a ship resistance model calculating the thrust necessary to counteract the hydrodynamic forces ; - a fuel consumption model calculating the fuel consumption corresponding to the thrust input; - a non linear optimization algorithm calculating the optimal speed profile. In order to evaluate the fuel consumption of an inland vessel, a ship resistance numerical model is developed in the first part of this PhD. This 3D numerical model simulates the flow around an inland self-propelled vessel and evaluates the hydrodynamic forces acting on the hull. A RANS solver is coupled with a quasi-Newton approach to find the equilibrium position and calculate ship sinkage. This method is validated by comparing the results of numerical simulations to towing tank tests. The numerical results with and without sinkage are also compared to study the influence of sinkage on ship resistance and on the accuracy of the method. Additionally, some empirical models are investigated and compared with the accuracy of the numerical method. Finally, the numerical model is used to determine if channel with and water depth restriction contribute to the same amount of ship resistance increase for the same level of restriction. The results of that investigation give insight to whether channel restriction can be characterized by a unique parameter (for instance the blockage ratio) or two parameters to distinguish water depth and channel with effects. In the second part of this PhD, the numerical methods used in the speed optimization model are described and validated. The speed optimization model is then used to simulate a real case: the itinerary of the self-propelled ship Oural on river Seine, between Chatou and Poses (153 km). The optimized fuel consumption is compared with the non-optimized fuel consumption, based on AIS speed profile retrieved on this itinerary. The effects of the ship trajectory and travel duration on fuel consumption are also investigated. The results of those investigations showed that optimizing the ship speed lead to an average fuel saving of 8 % and that using an optimal track and including real time information such as lock availability and river traffic can lead to additional fuel savings
To, Suk-kwan. "The effectiveness of a reading module in enhancing junior students' reading motivation and conceptual knowledge Ti sheng chu zhong xue sheng yue du dong ji ji wen hua zhi shi dan yuan jiao xue cheng xiao yan jiu /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B40039985.
Повний текст джерелаGomit, Guillaume. "Développement de techniques de mesure de surfaces libres par moyens optiques : Application à l'analyse de l'écoulement généré par un modèle de bateau en bassin des carènes." Phd thesis, Université de Poitiers, 2013. http://tel.archives-ouvertes.fr/tel-01062934.
Повний текст джерелаPloé, Patrick. "Surrogate-based optimization of hydrofoil shapes using RANS simulations." Thesis, Ecole centrale de Nantes, 2018. http://www.theses.fr/2018ECDN0012/document.
Повний текст джерелаThis thesis presents a practical hydrodynamic optimization framework for hydrofoil shape design. Automated simulation based optimization of hydrofoil is a challenging process. It may involve conflicting optimization objectives, but also impose a trade-off between the cost of numerical simulations and the limited budgets available for ship design. The optimization frameworkis based on sequential sampling and surrogate modeling. Gaussian Process Regression (GPR) is used to build a predictive model based on data issued from fluid simulations of selected hydrofoil geometries. The GPR model is then combined with other criteria into an acquisition function that isevaluated over the design space, to define new querypoints that are added to the data set in order to improve the model. A custom acquisition function is developed, based on GPR variance and cross validation of the data.A hydrofoil geometric modeler is also developed to automatically create the hydrofoil shapes based on the parameters determined by the optimizer. To complete the optimization loop, FINE/Marine, a RANS flow solver, is embedded into the framework to perform the fluid simulations. Optimization capabilities are tested on analytical test cases. The results show that the custom function is more robust than other existing acquisition functions when tested on difficult functions. The entire optimization framework is then tested on 2D hydrofoil sections and 3D hydrofoil optimization cases with free surface. In both cases, the optimization process performs well, resulting in optimized hydrofoil shapes and confirming the results obtained from the analytical test cases. However, the optimum is shown to be sensitive to operating conditions
Daniel, Aang. "Routing and Scheduling with Time Windows: Models and Algorithms for Tramp Sea Cargos and Rail Car-Blocks." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19698.
Повний текст джерелаCommittee Chair: Al-Khayyal, Faiz; Committee Member: Barnes, Earl; Committee Member: Johnson, Ellis; Committee Member: Karimi, IA; Committee Member: Sokol, Joel.
Linder, Jonas. "Indirect System Identification for Unknown Input Problems : With Applications to Ships." Doctoral thesis, Linköpings universitet, Reglerteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134126.
Повний текст джерелаTill skillnad från många andra industrier där avancerade styrsystem har haft en omfattande utveckling under de senaste decennierna så har styrsystem för skepps- och marinindustrin inte alls utvecklats i samma utsträckning. Det är framförallt under de senaste 10 åren som lagkrav och stigande driftskostnader har ökat intresset för effektivitet och säkerhet genom användning av styrsystem. Rederier och den marina industrin är nu intresserade av hur de avancerade styrsystem som används inom andra områden kan tillämpas för marina ändamål. Huvudmålet är typiskt att minska den totala energianvändningen, och därmed också bränsleförbrukningen, genom att hela tiden planera om hur skeppet skall användas med hjälp av ny information samt styra skeppet och dess ingående system på ett sätt som maximerar effektiviteten. För många av dessa avancerade styrsystem är det grundläggande att ha en god förståelse för beteendet hos det systemet som skall styras. Ofta används matematiska modeller av systemet för detta ändamål. Sådana modeller kan skapas genom att observera hur systemet reagerar på yttre påverkan och använda dessa observationer för att finna eller skatta den modell som bäst beskriver observationerna. Observationerna är mätningar som görs med så kallade sensorer och tekniken att skapa modeller från mätningarna kallas för systemidentifiering. Detta är i grunden ett utmanande problem och det kan försvåras ytterligare om de sensorer som behövs inte finns tillgängliga eller är för dyra att installera. I denna avhandling föreslås en ny teknik där de mätningar som finns tillgängliga används på ett nytt och annorlunda sätt. Detta kan minska mängden nödvändiga sensorer eller möjliggöra användandet av alternativa sensorer i modell-framtagningen. Med hjälp av denna nya teknik kan enkla sensorer användas för att skatta en matematisk modell för en del av skeppet på ett sätt som inte är möjligt med traditionella metoder. Genom att skatta denna modell kan fysikaliska egenskaper hos skeppet, så som dess massa och hur massan är fördelad över skeppet, övervakas för att upptäcka förändringar. Just dessa två egenskaper har stor inverkan på hur skeppet beter sig och om skeppet är fellastat kan det i värsta fall kapsejsa. Vetskapen om dessa fysikaliska egenskaper kan alltså utöver effektivisering användas för att varna besättningen eller påverka styrsystemen så att farliga manövrar undviks. För att visa att tekniken fungerar i verkligheten har den använts på mätningar som har samlats in från ett skalenligt modellskepp. Experimenten utfördes i bassäng och resultaten visar att tekniken fungerar. Denna nya teknik är inte specifik för marint bruk utan kan också vara användbar i andra typer av tillämpningar. Även i dessa tillämpningar möjliggörs användandet av färre eller alternativa sensorer för att skatta modeller. Tekniken kan vara speciellt användbar när en modell av ett system eller process som verkar i ett nätverk av många system är av intresse, något som också diskuteras i avhandlingen.
Зайцев, В. В. "Наукові основи ефективного транспортування стиснутого природного газу морськими акваторіями". Thesis, Івано-Франківський національний технічний університет нафти і газу, 2013. http://elar.nung.edu.ua/handle/123456789/4625.
Повний текст джерелаДиссертация посвящена решению важной народнохозяйственной проблемы - быстрого альтернативного снабжения Украины природным газом. Цель исследования - разработка научных основ эффективной транспортировки сжатого природного газа морскими акваториями с помощью специальных судов-газовозов, судов-контейнеровозов и барж. Методы исследования приняты аналитические и численные. Ожидаемый годовой экономический эффект составляет 500...700 млн. дол. США. Установлено, что на сегодня отсутствуют результаты теоретических исследований о транспортировке сжатого природного газа с помощью подвижных трубопроводов на судах-носителях, публикации по определению технико-экономических показателей подвижных трубопроводов, расчетные эксперименты, позволяющие выявлять особенности процесса нагружения подвижного трубопровода внутренним давлением от транспортируемого сжатого газа. Отсутствуют на сегодня как теоретические, так и экспериментальные работы, которые бы позволили исследовать НДС подвижных трубопроводов и их элементов. Исследованы такие задачи: проведение анализа методов транспортировки природного газа морскими акваториями; разработка теоретико-методологических принципов формирования технологий транспортировки сжатого природного газа через морские акватории и концептуальных решений такой транспортировки судами-контейнеровозами, баржами и носителями на воздушной подушке; разработка основ расчетов и проектирования элементов подвижных трубопроводов для транспортировки сжатого газа; разработка основ расчетов и проектирования CNG-модулей с баллонами высокого давления и исследование их массогабаритных характеристик; разработка принципов размещения модулей на судах и их объединения в подвижный трубопровод; разработка основ расчетов и проектирования судов-носителей подвижных трубопроводов, их устройств и систем; проведение экономической оценки системы морской транспортировки сжатого природного газа с использованием контейнеровозов и барж. В диссертационной работе впервые разработана концепция транспортировки сжатого природного газа с помощью специализированных контейнеровозов, подвижных трубопроводов на барже, на СВП и с помощью подводного носителя подвижного трубопровода. Впервые разработаны комплексные основы проектирования и расчетов элементов CNG-мoдyлeй, в том числе коническо-цилиндрических и коническо-сферических. Доказано, что для CNG-газовозов целесообразно использовать баллоны, изготовленные из композиционных полимерных материалов, что увеличивает долю массы природного газа в общей массе баллона с газом по сравнению с металлическими баллонами. Практическое значение исследований определяется тем, что математические модели, методы расчетов и проектирования подвижных трубопроводов, полученные в работе результаты, могут быть использованы не только для контейнеровозов, барж, но и для других типов носителей подвижных трубопроводов. Использование полученных в работе результатов исследований, а именно, методов расчетов прочности элементов подвижных трубопроводов, методов для анализа процесса транспортировки CNG с помощью подвижного трубопровода, НДС элементов подвижного трубопровода с помощью МКЭ дают возможность инженерам, конструкторам, проектировщикам и студентам проводить анализы прочности подвижных трубопроводов, а также выявлять и использовать их резервы прочности, конструировать и строить подвижные трубопроводы на основе достоверных и современных методов. Приведены практические рекомендации по проектированию и эксплуатации подвижных трубопроводов и их носителей и элементов. Достоверность результатов исследований подтверждена корректным применением соответствующих методов научных исследований, к которым относятся: теория тонких оболочек, теория мягких оболочек и метод конечных элементов, соответствием результатов расчетов проведенных с помощью аналитических методик результатам, полученными с помощью МКЭ.
Dissertation is dedicated to important National Economy problem - rapid alternative natural gas supply of Ukraine. The purpose of research - development of scientific bases for effective transportation of compressed natural gas through marine areas with the help of special gas carriers, container ships and barges. In dissertational work first time developed the concept of transporting CNG by container ships, movable pipelines on a barges, on hovercrafts and using underwater carrier of movable pipeline. The first time developed the foundations of design and analysis of elements of CNG-modules. It is proved that for CNG-gas carriers advisable to use cylinders made from polymer materials, which increases the proportion of the mass of gas to the total weight of cylinder as compared to metal cylinders.
Rizvi, Syed. "Physical and computational models of the gloss exhibited by the human hair tress : a study of conventional and novel approaches to the gloss evaluation of human hair." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/physical-and-computational-models-of-the-gloss-exhibited-by-the-human-hair-tress-a-study-of-conventional-and-novel-approaches-to-the-gloss-evaluation-of-human-hair(feba6616-b83c-4a03-83f6-32c8b7009cc8).html.
Повний текст джерелаErny, Carole. "Prévision de l'amorçage de fissures de fatigue dans des assemblages soudés pour applications navales." Brest, 2010. http://www.theses.fr/2010BRES2063.
Повний текст джерелаShip structures are usually built by using welding process and are submitted to some variable and complex loadings. The welding process induces specific geometries at the weld toe where local stress concentrations are generated and also creates various mechanical properties in the heat affected zone. Accordingly, welded joints could be a critical area for fatigue damage. In a previous work, a methodology to predict fatigue life has been developed and tested on butt-welded joints. To go further, the present work focuses on more complex assemblies in order to validate this strategy and be able to estimate the fatigue life of representative ship structures. First, the methodology consists of the elastic shakedown study of the structure and then of a post-treatment which predicts the fatigue crack initiation. A comparison between experimental and numerical results is proposed in order to present the accuracy of the proposed strategy to predict fatigue life time of welded assemblies typical of shipbuilding applications
Suphaphiphat, Karunasinee. "Anti-viral immune response in the semen of cynomolgus macaques and inhibition of cell to cell transmission by broadly neutralizing antibodies in an SIV/SHIV model of infection SHIV162P3 transmission by semen 1 leukocytes is efficiently 2 inhibited by broadly neutralizing antibodies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS599.
Повний текст джерелаHIV-1 sexual transmission occurs mostly through contaminated semen, which contains both free virions and infected leukocytes. Moreover, factors in seminal plasma (SP) can influence both semen infectivity and host’s response. Therefore, we used the experimental model of Simian Immunodeficiency Virus (SIV) infection of macaques, to investigate semen cells infectivity and the antiviral immune responses and to evaluate the potency of broadly neutralizing antibodies (bNAbs) to block cell-to-cell virus transmission.In SIVmac251 infected cynomolgus macaques, we investigated SIV-specific innate and adaptive responses in semen, including CD8+ T cell response, humoral response and levels of cytokines, chemokines and growth factors. SIV infection induced pro-inflammatory and immunoregulatory cytokines in semen and a concomitant upregulation of activated CD69+ CD8+ T cells and CCR5+ CXCR3+ CD8+ T cells. Neither SIV-specific CD8+ T-cell responses nor humoral responses controlled seminal viral shedding. Failure to control viral replication in SIV-infected semen is related to a general inflammation and immune activation, which possibly mirrors what happen in the male genital tract and which could lead to enhanced HIV/SIV transmission.Moreover, we developed cell-to-cell transmission assays, using either TZM-bl or human PBMC as target cells and SHIV162P3-infected splenocytes and CD45+ semen leukocytes as donor cells, and evaluated bNAbs-mediated inhibition. The bNAb panel included four 1st generation bNAbs and eight 2nd generation bNAbs. A combination of 1st generation bNAbs (2F5+2G12+4E10) was able to efficiently inhibit CAV transmission, while double combination or single bNAbs showed reduced potency. Of note, individual 2nd generation bNAbs inhibited transmission as efficiently as bNAbs combinations. An anti-V3 bNAb has been selected to evaluate its potential to block cell-to-cell transmission in vivo
Robert, Marie. "Modélisation numérique du comportement hydroélastique des navires sur houle non linéaire." Thesis, Ecole centrale de Nantes, 2017. http://www.theses.fr/2017ECDN0047.
Повний текст джерелаThe increase of large ships dimensions shifts their structural natural frequencies towards common wave frequencies, inducing more interactions between the classic seakeeping response and the structural response. Accurate modeling of wavestructure interactions becomes a key issue for architects and classification societies during the design of a ship. In this respect, a new numerical tool for fluidstructure interaction is developed, combining a finite difference RANSE description of the fluid domain with ICARE-SWENSE and an analytic beam model, within a modal approach. Thanks to the use of a simple formulation for the structure part, the tool inherits ICARE-SWENSE tolerance properties with regard to large time steps, while still taking into account hydrodynamic nonlinear effects. Results presented for a flexible barge in diffraction and radiation according to flexible modes validate the first steps of the coupling procedure. Special consideration is given to hydrodynamic non linearities threshold and their impact on the structural response. A first implementation is shown for the resolution of the equation of motion for the elastic degrees of freedom. Parametric studies on ship resistance in both regular and bichromatic waves are included as a stepping stone towards future simulations of ship hydroelasticity in irregular waves
Linot, Fabrice. "Apport des Surfaces à Haute Impédance à la conception d'antennes réseaux compactes et d'antennes réseaux à très large bande passante." Phd thesis, Télécom ParisTech, 2011. http://pastel.archives-ouvertes.fr/pastel-00617270.
Повний текст джерелаZouaoui-Elloumi, Salma. "Reconnaissance de comportements de navires dans une zone portuaire sensible par approches probabiliste et événementielle : application au Grand Port Maritime de Marseille." Phd thesis, Ecole Nationale Supérieure des Mines de Paris, 2012. http://pastel.archives-ouvertes.fr/pastel-00737678.
Повний текст джерелаChiu, Yi-Ming, and 邱意明. "Application of Wireless Transmission Module to the Measurement of Ship Motions." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/40215435391642194866.
Повний текст джерела國立臺灣大學
工程科學及海洋工程學研究所
97
The purpose of this research is to investigate the feasibility of application of wireless transmission module to the measurement of ship motions. This research includes collocation and design of the wireless transmission module and the sensors, as well as the establishment of wireless communication mode. C programming language is used to control the micro-controller MSP430F1611, and the design of structure in wireless transmission module. Star topology is used as the frame of wireless communication to the measurement of ship motions. The wired measurement system might disturb the operation of crew. By the design of wireless transmission methods improve the problem just mentioned before.
Hopkins, Dwayne H. "Ship/model correlation study /." 2003.
Знайти повний текст джерелаYA-LING, CHEN, and 陳雅玲. "Create Champions Cradle of Taiwan High School Soccer:The Training Management Module Case Studies in Chung Shan Industrial and Commercial School Women's Soccer Team." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/bbn334.
Повний текст джерела康寧大學
休閒管理研究所
104
The soccer is most popular sport and common language in the world, Asian teams unable to reach top three of FIFA World Cup, Taiwan team more difficult to achieve the target, Taiwan soccer sport obviously being neglected compared to the other sport. In Taiwan Mulan women's soccer team had let soccer become the trend in the 70 's ,Because no players and lack of funds and government neglect and social factors, resulting Mulan women's soccer team was to halt recruitment. Now, in the world ranking Taiwan's women's soccer better than men's soccer but trend biased towards males. must rectify the defects from basic education. This paper uses qualitative field research methods, through interviews and case study on successful experiences in the training model and team management. This paper provides recommendations for basic training school on how to train soccer players, according to the times of changing into different management models and methods. A case in this thesis is often won the championship trophy women's soccer team of the Chung Shan Industrial and Commercial School the case has gone through a lot of difficulties but never give up and continue to overcome all difficulties. It received three League Championship trophies in five years. became champions cradle of Taiwan High School women's Soccer team. This paper will hope remind the Government attaches Taiwan's soccer environment, promote the professionalization of women's soccer development in the country and finally towards the international forward.
Woo, Jae-Kyung. "Gerber-Shiu analysis in some dependent Sparre Andersen risk models." Thesis, 2010. http://hdl.handle.net/10012/5343.
Повний текст джерелаPothina, Dharhas. "A multimodel approach to modeling bay circulation in shallow bay-ship channel systems." 2009. http://hdl.handle.net/2152/17394.
Повний текст джерелаtext
"A hedonic price model for commodity housing in Guang Zhou, China." 2001. http://library.cuhk.edu.hk/record=b5890742.
Повний текст джерелаThesis submitted in: November 2000.
Thesis (M.Phil.)--Chinese University of Hong Kong, 2001.
Includes bibliographical references (leaves 65-68).
Abstracts in English and Chinese.
Acknowledgements --- p.i
Abstract --- p.ii
摘要 --- p.iii
Table of Contents --- p.iv
List of Tables --- p.vi
List of Figures --- p.vi
Chapter Chapter 1 --- Introduction --- p.1
Chapter Chapter 2 --- Literature Review --- p.4
Chapter 2.1 --- Theoretical Model --- p.4
Chapter 2.2 --- Empirical Investigation --- p.9
Chapter 2.2.1 --- Choice of The Functional Form --- p.9
Chapter 2.2.2 --- Choice of Variables --- p.13
Chapter 2.2.3 --- Estimation of Supply and Demand Functions --- p.16
Chapter 2.2.4 --- Test of Heteroskedasticity --- p.17
Chapter 2.2.5 --- Test of Multicollinearity --- p.18
Chapter 2.2.6 --- Application of The Hedonic Price Model to Developing Countries --- p.20
Chapter 2.3 --- Concluding Remarks --- p.21
Chapter Chapter 3 --- Introduction of The Housing Market in Guang Zhou --- p.23
Chapter 3.1 --- Development and Current Situation --- p.23
Chapter 3.2 --- Some Caveats --- p.26
Chapter Chapter 4 --- Empirical Results --- p.30
Chapter 4.1 --- The Data --- p.30
Chapter 4.1.1 --- Dependent Variable --- p.34
Chapter 4.1.2 --- Locational Variables --- p.34
Chapter 4.1.3 --- Structural Variables --- p.35
Chapter 4.1.4 --- Neighbourhood Variables --- p.37
Chapter 4.2 --- The Results --- p.38
Chapter 4.2.1 --- Regression Results and Possible Interpretation --- p.40
Chapter 4.2.2 --- Test of Multicollinearity --- p.48
Chapter 4.2.3 --- Test of Heteroscedasticity --- p.50
Chapter 4.2.4 --- Test of Alternative Functional Forms --- p.55
Chapter 4.3 --- Possible Sources of Estimation Bias --- p.57
Chapter 4.4 --- Concluding Remarks --- p.59
Chapter Chapter 5 --- Conclusion --- p.61
References --- p.65
Ben, Salah Zied. "Some Applications of Markov Additive Processes as Models in Insurance and Financial Mathematics." Thèse, 2012. http://hdl.handle.net/1866/9066.
Повний текст джерелаThis thesis consists mainly of three papers concerned with Markov additive processes, Lévy processes and applications on finance and insurance. The first chapter is an introduction to Markov additive processes (MAP) and a presentation of the ruin problem and basic topics of Mathematical Finance. The second chapter contains the paper "Lévy Systems and the Time Value of Ruin for Markov Additive Processes" written with Manuel Morales and that is published in the European Actuarial Journal. This paper studies the ruin problem for a Markov additive risk process. An expression of the expected discounted penalty function is obtained via identification of the Lévy systems. The third chapter contains the paper "On a Generalization of the Expected Discounted Penalty Function to Include Deficits at and Beyond Ruin" that is submitted for publication. This paper presents an extension of the expected discounted penalty function in a setting involving aggregate claims modelled by a subordinator, and Brownian perturbation. This extension involves a sequence of expected discounted functions of successive minima reached by a jump of the risk process after ruin. It has important applications in risk management and in particular, it is used to compute the expected discounted value of capital injection. Finally, the fourth chapter contains the paper "The Minimal Entropy Martingale Measure (MEMM) for a Markov-Modulated Exponential" written with Romuald Hérvé Momeya and that is published in the journal Asia Pacific Financial Market. It presents new results related to the incompleteness problem in a financial market, where the risky asset is driven by Markov additive exponential model. These results characterize the martingale measure satisfying the entropy criterion. This measure is used to compute the price of the option and the portfolio of hedging in an exponential Markov-modulated Lévy model.