Дисертації з теми "Several mechanisms"
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Wolf, Edward. "Impact damage mechanisms in several laminated material systems." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/12823.
Повний текст джерелаYau, Desmond. "Analysis of coupling, guiding and radiation mechanisms on several microwave structures /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16164.pdf.
Повний текст джерелаSeehamart, Kompichit. "Investigation of the diffusion mechanisms of several hydrocarbons in the Metal-Organic-Framework Zn(tbip)." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-68125.
Повний текст джерелаGurevic, Ilya. "Studies on the hydride transfer and other aspects of several thymidylate synthase variants." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6586.
Повний текст джерелаCasalena, Lee. "Multimodal Nanoscale Characterization of Transformation and Deformation Mechanisms in Several Nickel Titanium Based Shape Memory Alloys." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1499568013015563.
Повний текст джерелаSeehamart, Kompichit [Verfasser], Jörg [Akademischer Betreuer] Kärger, and Berend [Akademischer Betreuer] Smit. "Investigation of the diffusion mechanisms of several hydrocarbons in the Metal-Organic-Framework Zn(tbip) / Kompichit Seehamart. Gutachter: Jörg Kärger ; Berend Smit. Betreuer: Jörg Kärger." Leipzig : Universitätsbibliothek Leipzig, 2011. http://d-nb.info/1020088958/34.
Повний текст джерелаCawthorn, Christopher John. "Several applications of a model for dense granular flows." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/245044.
Повний текст джерелаJones, Christopher David Stanford. "On the cross-sectional form of the patella in several primates." Title page, table of contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phj764.pdf.
Повний текст джерелаKong, Dali. "Analytical and numerical studies of several fluid mechanical problems." Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/3651.
Повний текст джерелаNunes, da Silva Ana Sofia. "Characterization of the molecular mechanisms involved in severe malaria pathogenesis." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC065.
Повний текст джерелаSequestration of infected erythrocytes (IEs) is the prime mediator of disease and is mediated by members of the highly diverse PfEMP1. The aim of this thesis was to characterize the molecular mechanisms associated to pregnancy associated malaria (PAM) and severe malaria, in order to design new intervention strategies to protect patients against severe malaria clinical symptoms. PfEMP 1 -VAR2CSA stands today as the leading vaccine candidate aiming to protect future pregnant women against the severe clinical outcomes of PAM. In order to better characterize the interactions between PfEMPI-VAR2CSA and its receptor CSA, we generated VAR2CSA specific nanobodies. Following immunization of a Ilama with the full-length VAR2CSA recombinant protein, we obtained 19 nanobodies, mainly targeting the DBL1X. Four nanobodies targeting DBL1X reproducibly inhibited CSA adhesion of erythrocytes infected with the homologous NF54-CSA parasite strain, providing evidences that DBL1X domain is part or close to the CSA binding site. Severe malaria was recently associated with binding of IEs, expressing domain cassettes DC8 and DC13, to Endothelial Protein C Receptor (EPCR) pr'sent in the host endothelium. In this study we demonstrated that the IT4VAR19-DC8 binds to EPCR with a greater affinity than the CIDRa1. L domain alone and also the binding to EPCR-expressing endothélial cell line (HBEC5i) is more pronounced. We observed that although IT4VAR19 is the preferentially selected EPCR-binding variant from IT4 strain, the humoral immunity against the EPCR binding IT4VAR19-DC8 cassette or the CIDRa1. 1 domain is not boosted during a severe pediatric malaria episode in Benin. In conclusion, this thesis provide new insights on the molecular mechanisms underlying the binding of P. Falciparum infected erythrocytes to the host endothelium that will help in the development of anti-adhesive strategies to protect patients against severe malaria clinical outcomes
Nieto-Silleras, Olmo. "Device-independent randomness generation from several Bell estimators." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271365.
Повний текст джерелаL'approche indépendante des appareils ("device-independent" en anglais) est une nouvelle approche en informatique quantique. Cette nouvelle approche exploite la non-localité de la physique quantique afin de certifier le bon fonctionnement d'une tâche sans faire appel à des suppositions sur les appareils menant à bien cette tâche. Cette thèse traite de la certification et la génération d'aléa indépendante des appareils pour des applications cryptographiques. L'existence de cet aléa repose sur une relation fondamentale entre le caractère aléatoire de la théorie quantique et sa non-localité, mise en lumière dans le cadre des tests de Bell. Les protocoles de génération d'aléa et de distribution quantique de clés indépendants des appareils mesurent en général l'aléa produit en fonction de la violation d'une inégalité de Bell donnée. Cependant les probabilités qui caracterisent les résultats de mesures dans un test de Bell sont plus riches que le degré de violation d'une seule inégalité de Bell. Dans ce travail nous montrons qu'une évaluation plus exacte de l'aléa présent dans les corrélations nonlocales peut être faite si l'on tient compte de plusieurs expressions de Bell à la fois ou de l'ensemble des probabilités (ou comportement) caractérisant l'appareil testé. De plus nous montrons qu'à chaque comportement correspond une expression de Bell optimale permettant de certifier la quantité maximale d'aléa présente dans ces corrélations. À partir de ces resultats, nous introduisons une famille de protocoles de génération d'aléa indépendants des appareils, sécurisés contre des adversaires classiques, et reposant sur l'évaluation de l'aléa à partir d'un nombre arbitraire d'expressions de Bell, ou même à partir des fréquences expérimentales des résultats de mesure. Les protocoles proposés permettent aussi d'évaluer l'aléa à partir d'un sous-ensemble de choix de mesure, ce qui peut être avantageux lorsque l'on considère des corrélations pour lesquelles certains choix de mesure produisent plus d'aléa que d'autres. Nous fournissons des exemples numériques illustrant l'avantage de cette méthode pour des données finies et montrons qu'asymptotiquement cette méthode résulte en un taux de génération d'aléa optimal à partir des données expérimentales, sans devoir supposer à priori que l'expérience viole une inégalité de Bell spécifique.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Oliveira, Jena Hanay Araujo de. "Aspectos psicol?gicos de obesos grau III antes e depois de cirurgia bari?trica." Pontif?cia Universidade Cat?lica de Campinas, 2006. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/376.
Повний текст джерелаEvaluates depression, anxiety, psychopathologic symptoms, alexithymia and defensive style of grade III obese patients, before and after bariatric surgery, as well as estimates the level of association among such variables. Methodological study design was correlational crosssectional type. 65 patients took part in the study (Group 1: surgical candidates vs. Group 2: postoperative patients), mainly females (92,3%), who answered the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Symptoms Assessment Scale (EAS- 40), and the version in Portuguese of The Toronto Alexithymia Scale (TAS-26) and of the Defensive Style Questionnaire (DSQ-40). Gr 1 showed mild anxiety and depression levels and Gr 2 minimum level (respectively, p< 0,001 e p< 0,01). The total average score for EAS- 40 and F2 and F3 (obesity-compulsion and somatization) were higher in Gr 1 when compared to Gr 2 (repetitively, p< 0,005, p< 0,005 e p< 0,001). On TAS, the total average score for F1 (ability to identify and describe feelings and distinguish them from bodily sensations) were higher in Gr 1 than in Gr 2 (respectively, p< 0,01 e p< 0,005). According to DSQ-40, there was a tendency for an immature defensive style in Gr 1 in comparison to Gr 2 (p< 0,02). In relation to the association between the variables and BMI, the correlations were negative for Gr 1 and F2 of TAS (daydreaming, p < 0,05) and for the mature factor of DSQ- 40 and Gr 2 (p < 0,05), which shows a trend towards a more mature and adaptive style in Gr 2. Correlations were positive and significant in relation to immature defenses - acting out (Gr 1: p<0,005 and Gr 2: p<0,05) and in the autistic fantasy in Gr 1 (p<0,05). The results show the psychological status of the participants, who are apt for bariatric surgery and point to a decrease in psychopathological symptoms proportional to weight loss after surgery.
Avalia depress?o, ansiedade, sintomas psicopatol?gicos, alexitimia e o estilo defensivo de pacientes obesos grau III, antes e depois de cirurgia bari?trica, e estima o grau de associa??o entre essas vari?veis. O delineamento metodol?gico foi correlacional de tipo cross-sectional. Participaram do estudo 65 pacientes (Gr 1: pr?-cir?rgico vs. Gr 2: p?scir?rgico), predominantemente do sexo feminino (92,3%), que responderam o Invent?rio de Depress?o de Beck (BDI), o Invent?rio de Ansiedade de Beck (BAI), a Escala de Avalia??o de Sintomas (EAS-40), a Vers?o em Portugu?s da Escala de Alexitimia de Toronto (TAS-26) e a Vers?o em Portugu?s da Defensive Style Questionnaire (DSQ-40). O Gr 1 apresentou n?vel de depress?o e ansiedade leve e o Gr 2 n?vel m?nimo (respectivamente, p< 0,001 e p< 0,01). O escore m?dio total da EAS-40 e de F2 e F3 (obsessividade-compulsividade e somatiza??o) foram mais elevados no Gr 1 quando comparados aos do Gr 2 (respectivamente, p< 0,005, p< 0,005 e p< 0,001). Na TAS, o escore m?dio total e de F1 (habilidade de identificar e descrever sentimentos e distingui-los de sensa??es corporais) foram maiores no Gr 1 do que no Gr 2 (respectivamente, p< 0,01 e p< 0,005). De acordo com o DSQ-40, houve tend?ncia a um estilo defensivo imaturo no Gr 1 quando comparado ao Gr 2 (p< 0,02). Em rela??o ? associa??o das vari?veis com o IMC, as correla??es foram negativas no Gr 1 e o F2 da TAS (sonhar acordado, p < 0,05) e no fator maduro do DSQ-40 e o Gr 2 (p < 0,05), apontando uma propens?o de estilo mais maduro e adaptativo no Gr 2. As correla??es foram positivas e significantes nas defesas imaturas acting out (Gr 1: p<0,005 e Gr 2: p<0,05) e na fantasia aut?stica no Gr 1 (p<0,05). Os resultados mostram o modo de funcionamento psicol?gico dos participantes aptos ? cirurgia bari?trica e assinalam uma diminui??o da sintomatologia psicopatol?gica na propor??o da perda de peso ap?s a cirurgia.
Chell, Benjamin James. "Psychological mechanisms underpinning severe performance loss in sport : applying theory to practice." Thesis, Sheffield Hallam University, 2005. http://shura.shu.ac.uk/20641/.
Повний текст джерелаIseri, Erkut Inan. "Exciton Simulations Of The Optical Properties Of Several Photosynthetic Light-harvesting Complexes." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605040/index.pdf.
Повний текст джерелаMills, Nathan (Nathan Matthew). "Design and testing of a pan-tilt mechanism for severe environments." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104300.
Повний текст джерелаThesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 210).
U.S. Navy ships have non-rotating radar and electronic warfare devices installed, which are often supported and trained by two-axis gimbals. In current shipboard solutions the payloads are often placed on a platform above the gimbal drive train, which results in high moment loads on drive components during a wave impact. As the payloads grow in size, the moment grows as well, and the current gimbal design is insufficient to support some payload geometries. This thesis presents a novel design for a low-mass two-axis machine that supports large payloads without large impact moments by locating the center of action along the axis of rotation. A functional prototype intended for shipboard installation was manufactured, assembled, and characterized in laboratory tests. The prototype was also subjected to environmental testing to military standards for temperature, vibration, and shock. Future improvements in machine function, promising areas for optimization, and an initial direction for taking the machine from prototype to product are presented.
by Nathan Mills.
Nav. E.
S.M.
Hall, Sara L. M. S. "Molecular Mechanisms of Synergy Between IL-13 and IL-17A in Severe Asthma." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125099399164.
Повний текст джерелаLeung, Hiu-lan Nancy, and 梁曉灡. "Mechanism of antibody-dependent enhancement in severe acute respiratory syndrome coronavirus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47327066.
Повний текст джерелаpublished_or_final_version
Microbiology
Master
Master of Philosophy
Li, Siran. "Analysis of several non-linear PDEs in fluid mechanics and differential geometry." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:20866cbb-e5ab-4a6b-b9dc-88a247d15572.
Повний текст джерелаTorrance, Hew D. T. "Immune dysfunction following severe polytrauma & major surgery : exploring mechanisms & identifying potential therapies." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24865.
Повний текст джерелаBeautyman, Michael John Jr. "Load bearing interface design for a pan-tilt mechanism for severe marine environments." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111896.
Повний текст джерелаThesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 123-125).
The Naval Research Laboratory (NRL) requested the design of a two-axis gimbal device for the shipboard support of a sensor payload. Previous design efforts presented a low-mass two-axis (pan and tilt) machine. Vibration and shock testing induced failure in the interface between the payload and the tilt shaft, through which the control cabling connected to the sensors, taking the system out of service and creating a hazard for Sailors. This thesis proposes a tapered, hollowed shaft and flange interface connected by an interference fit that is preloaded and retained by a single hollowed bolt for ease of maintenance at sea. This simplified design is a departure from existing rotary tapered interfaces, such as seen in machine tooling, and focuses on connecting massive payloads to their actuators when subjected to severe loading. This design is uniquely suited to withstand large bending moments and loading as demanded by military standards for shock. A custom rig was designed and constructed to subject reduced-scale designs to military standard environmental testing for shock in the laboratory. These test results were analyzed using moving average filtering to develop confidence intervals to validate the design mathematics. A full-scale prototype was manufactured and subjected to shock testing and analysis. The design exceeded all requirements and is ready for immediate integration into the gimbal. This research also revealed the potential for tapered interfaces to connect massive payloads to their actuators in industry.
by Michael John Beautyman, Jr.
Nav. E.
S.M.
Golde, Sabrina Helena [Verfasser]. "Neurobiological mechanisms of emotion inhibition under stress in severe early life trauma / Sabrina Helena Golde." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223929027/34.
Повний текст джерелаClark, Jessica Ann. "NEUROPSYCHOLOGICAL CORRELATES AND UNDERLYING CORTICAL MECHANISMS OF WORKING MEMORY IN MODERATE TO SEVERE TRAUMATIC BRAIN INJURY." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/3.
Повний текст джерелаFisher, Rebecca. "The underlying mechanisms : an investigation of attachment and mentalization within adolescent severe and enduring mental ill health." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/6000.
Повний текст джерелаGrampa, Valentina. "Characterization of the pathophysiological mechanisms associated with NEK8/NPHP9 mutations identified in patients with severe renal ciliopathies." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB099.
Повний текст джерелаCiliopathies are a group of genetic multi-systemic disorders related to dysfunction of the primary cilium, a sensory organelle present at the cell surface that regulates key signaling pathways during development and tissue homeostasis. In order to identify novel genes whose mutations would cause severe developmental ciliopathies, ~500 patients/fetuses were analyzed by a targeted high throughput sequencing approach allowing exome sequencing of > 1200 ciliary genes. We have identified eight novel mutations in NEK8/NPHP9 in five independent families with severe overlapping syndromic disorders. NEK8/NPHP9 encodes a NIMA-related kinase that localizes at the inversin compartment of the primary cilium and acts as a regulator of Hippo signaling, a pathway that is essential for control of organ size during development. We show for the first time that NEK8 mutations are associated with renal agenesis and hypodysplasia, and our work highlights a genotype/phenotype correlation with NEK8 loss-of-function mutations leading to enlarged cystic kidney, pancreas and liver, whereas NEK8 gain-of-function (missense) mutations cause renal hypodysplasia, cardiopathy and paucity of bile ducts. The first part of my thesis project focuses on the study of the impact of these NEK8 missense mutations on various cellular processes and NEK8-dependent signaling pathways. We demonstrate that NEK8 missense mutations impair the Inversin (INVS) compartment composition and ciliogenesis, and also alter the nuclear localization of the main Hippo signalling effector, YAP, as well as expression of its target genes in patient fibroblasts and renal cell lines. We also demonstrated that this Hippo pathway imbalance causes epithelial morphogenesis defects in 3D matrigel culture. Indeed, mIMCD3 cells depleted for NEK8 showed persistent YAP and Ki-67 staining and formed bigger spheres compared to control cells. Abnormal sphere volume was also observed in cells re-expressing NEK8-GFP mutations, suggesting their pathogenicity. We confirm these data in vivo in Jck mice, a model of polycystic kidney disease bearing a Nek8 missense mutation. Finally, treatment with Verteporfin, a specific inhibitor of YAP transcriptional activity, improves the mutant phenotype of both cellular models and zebrafish embryos overexpressing human NEK8, further supporting the involvement of YAP dysregulation in the pathogenic cellular mechanisms. Surprisingly, in patient fibroblasts, we showed that mutated NEK8 accumulates at the Golgi that appeared dispersed. NEK8 recruitment at the Golgi apparatus is dependent on ARF1 (Brefeldin A sensitive), a small GTPase involved in protein trafficking between Golgi compartments and ER. We notably demonstrated that NEK8 mostly interacts and localizes with the dominant negative form of ARF1 (T31N), suggesting that NEK8 could act as an activator (GEF) of ARF1 to promote vesicular trafficking of ciliary proteins. The second part of my project focuses on a new candidate gene for which a missense homozygous mutation has been identified in 3 individuals presenting a late onset NPH with hepatic fibrosis. This gene encodes ANKS3, an evolutionarily conserved protein whose function is still poorly characterized. Interestingly, ANKS3 has been reported to be a partner of NEK8, even though we showed it does not localize at the INVS compartment with NEK8 but is rather present at the base of cilia in fibroblasts. We showed that the missense mutation does not affect ANKS3 localization but leads to longer cilia and abnormal accumulation of NEK8 at the cilium base in patient fibroblasts and kidney tubules. Altogether, my work focused on NEK8 and its partners, ANKS6 and ANKS3, each of whose related gene is mutated in patients presenting a broad clinical spectrum of phenotypes. (...)
Mohseni, Hamidreza Materials Science & Engineering Faculty of Science UNSW. "Microstructural development and thermal stability of aluminium-based composites processed by severe plastic deformation." Awarded by:University of New South Wales. School of Materials Science and Engineering, 2006. http://handle.unsw.edu.au/1959.4/26793.
Повний текст джерелаFerron, Joëlle C. Strom-Gottfried Kim. "Psychological mechanisms to treatment adherence among people with severe mental illness validating treatment motivation and working alliance measures /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1473.
Повний текст джерелаTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Social Work." Discipline: Social Work; Department/School: Social Work.
Lennard, A. T. "An investigation of drought in the Severn Trent Water region : re-evaluating drought severity, characteristics and generating mechanisms." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004783/.
Повний текст джерелаSchneider, Nathan A. "Prediction of surface ship response to severe underwater explosions using a virtual underwater shock environment." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2003. http://library.nps.navy.mil/uhtbin/hyperion-image/03Jun%5FSchneider.pdf.
Повний текст джерелаThesis advisor(s): Young S. Shin. Includes bibliographical references (p. 161-162). Also available online.
Takemi, Tetsuya. "Studies on the Structure, Evolution, and Maintenance Mechanism of a Severe Squall Line in an Arid Region." 京都大学 (Kyoto University), 1998. http://hdl.handle.net/2433/86315.
Повний текст джерелаShi, Haijian. "Nonlinear finite element modeling and characterization of guyed towers under severe loading." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4703.
Повний текст джерелаThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 29, 2008) Vita. Includes bibliographical references.
Biserova, Tahchieva Alisiya. "Estudio del comportamiento del acero inoxidable dúplex y superdúplex después de deformación plástica severa." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672573.
Повний текст джерелаDuplex stainless steels (DSS) are characterized by their attractive properties of mechanical strength and corrosion resistance, due to the balanced microstructure of ferrite (δ) and austenite (γ). However, they are susceptible to secondary phase precipitation during uncontrolled manufacturing processes or heat treatments. The formation of these phases, particularly sigma (σ) phase, enriched in Cr and Mo, and intermetallic nitrides/carbides (Cr2N, M23C6), occurs in the range of 600ºC and 900ºC during different time. They are particularly investigated since they can decrease the mechanical properties and corrosion resistance of the material, depending on their amount in the microstructure. Unlike the conventional processes that are carried out to obtain these steels, severe plastic deformation process (SPD) by high-pressure torsion (HPT) provides extraordinary mechanical properties to the material due the obtained nanostructure, maintaining to a certain point its initial dimensions. Obtaining an ultra-fine grain microstructure or nanostructure entails internal changes from the thermodynamic point of view, an increase in internal energy due to the increments of grain boundaries. Consequently, the precipitation of the secondary phases would be altered. On the other hand, the introduction of interstitial elements from the surface to the inner part of the material by diffusion, mainly by thermochemical methods, such as nitriding or carburizing, can influence the formation of the undesirable phases. Consequently, the precipitation in the microstructure is affected and it is opportune to determine the influences of these modifications. The current thesis proposes the study and microstructural analysis of duplex stainless steel UNS S32205 and superduplex stainless steel UNS S32750 after being deformed by high-pressure torsion. A comparison between the annealed materials and the deformed materials is carried out to see the influence of the mechanical process on the evolution of secondary phase precipitation. The characterization of the different phases has been realized by using Scanning Electron Microscope - SEM, as well as the Electron Basckscatter Diffraction – EBSD technique to determine the distribution of the phases and their crystalline orientation. In addition, Transmission Electron Microscope - TEM and the Precession Electron Diffraction - PED technique as a high-resolution techniques have been used for a better interpretation of the secondary phases. The use of the Automatic Crystal Orientation Measurements – ACOM method has been required after observing the limitation of EBSD for the distribution and crystalline orientation determination of the nanostructured samples, being deformed by HPT. The improvement in mechanical properties has been determined by microhardness tests and the influence of the secondary phases has been analysed on the general corrosion behaviour of the materials. The results showes that the precipitation in both duplex and superduplex stainless steel is basically of sigma phase (σ) and of chromium nitrides (Cr2N), observed after an isothermal treatment after the severe plastic deformation. The increase in shear deformation causes a nanostructure and after an isothermal treatment, the secondary phases increase considerably in quantity, especially in the superduplex stainless steel. This contributes to the increase in the hardness of the material due to the phenomenon of aging by deformation, compared to the same material without having been deformed by HPT. In both cases, precipitation is considered as an invariant transformation, where sigma phase is a product of a solid- state initial phase with different crystalline structure. The general corrosion behaviour of both stainless steels is not deteriorated and it shows stable passivation due to the nanostructuring of the materials. Nitriding and carburizing as thermochemical processes considerably influence the increase in sigma phase precipitation, without significantly altering the corrosion behaviour.
Gilby, Krista Lynn. "An investigation into the mechanism responsible for Clomethiazole-induced neuroprotection in a rat model of severe global ischemia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0016/NQ57363.pdf.
Повний текст джерелаAlbertsson, Pontus. "Occupant casualties in bus and coach traffic : injury and crash mechanisms." Doctoral thesis, Umeå : Deptartment of Surgical and Perioperative Sciences, Division of surgery, Umeå university, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-482.
Повний текст джерелаHogan, Lynne. "An exploration of the coping mechanisms of caregivers of persons diagnosed with severe mental illness, in the Western Cape, South Africa." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20701.
Повний текст джерелаSuleman, Farhana. "Characterisation of the Phenotype and Disease Mechanisms in a Knock-In Mouse Model of Severe Pseudoachondroplasia Resulting from a D469 Comp Mutation." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518430.
Повний текст джерелаMantovani, Rocco. "Modelling complex systems in the severely undersampled regime: a Bayesian model selection approach." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18019/.
Повний текст джерелаTan, Evren. "Severe Plastic Deformation Of Age Hardenable Aluminum Alloys." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614968/index.pdf.
Повний текст джерелаm and re-adjustment of process parameters for each alloy type is evaluated as disadvantage. Therefore, recently there have been many research studies for development of alternative manufacturing techniques for aluminum alloys. Research activities have shown that it is possible to improve the strength of Al-alloys remarkably by severe plastic deformation which results in ultra-fine grain size. This study aims to design and manufacture the laboratory scale set-ups for severe plastic deformation of aluminum alloys, and to characterize the severely deformed samples. The stages of the study are summarized below: First, for optimization of die design and investigation of parameters affecting the deformation finite element modeling simulations were performed. The effects of process parameters (die geometry, friction coefficient) and material properties (strain hardening, strain-rate sensitivity) were investigated. Next, Equal Channel Angular Pressing (ECAP) system that can severely deform the rod shaped samples were designed and manufactured. The variations in the microstructure and mechanical properties of 2024 Al-alloy rods deformed by ECAP were investigated. Finally, based on the experience gained, a Dissimilar Channel Angular Pressing (DCAP) system for severe plastic deformation of flat products was designed and manufactured
then, 6061 Al-alloy strips were deformed. By performing hardness and tension tests on the strips that were deformed by various passes, the capability of the DCAP set-up for production of ultra-fine grain sized high-strength aluminum flat samples were investigated.
Nakajima, Tamie, Yukio Yamori, Katsumi Ikeda, Satoru Tsuchikura, Xiaofang Jia, Hazuki Tamada, Nozomi Yamagishi, et al. "Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat." Thesis, Springer, 2012. http://hdl.handle.net/2237/16803.
Повний текст джерелаMandala, Wilson Lewis. "Immunological mechanisms that determine why some African children develop severe malarial anaemia while others develop cerebral malaria in response to infection with Plasmodium falciparum." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485895.
Повний текст джерелаLütticke, Ashley L. [Verfasser], and Thomas [Akademischer Betreuer] Schulze. "Understanding the involvement of environmental exposures, genetic risk, and epigenetic mechanisms in the course of severe mental illness / Ashley L. Lütticke ; Betreuer: Thomas Schulze." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1216417806/34.
Повний текст джерелаAl, Mashhadani Mahmood Yaseen Hachim [Verfasser]. "The use of integrative OMICs to decipher heterogeneous chronic complex disease mechanism : severe asthma as a model / Mahmood Yaseen Hachim Al Mashhadani." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1227545096/34.
Повний текст джерелаTort, Morgan. "The effects of severe plastic deformation on an age hardenable Al-2.5Cu-1.5Mg alloy." Thesis, Clermont-Ferrand 2, 2015. http://www.theses.fr/2015CLF22578.
Повний текст джерелаThe effects of equal channel angular pressing (ECAP), a severe plastic deformation (SPD) technique, were investigated in an age hardenable Al-2.5Cu-1.5Mg (weight percent (wt.%)) alloy precipitating in the α + S phase field. A variety of microscopy, calorimetry and analytical techniques were employed to characterize and quantify the microstructure, including transmission kikuchi diffraction (TKD), transmission electron microscopy (TEM), differential scanning calorimetry (DSC) and atom probe tomography (APT). Four different initial heat-treatments were conducted to achieve four different microstructures, containing either no precipitates, Cu-Mg clusters or/and Al2CuMg intermetallics. Each specimen was subjected to ECAP at room temperature and the related effects on the microstructure and mechanical properties were analysed. Compression experiments for small strains (less than 7%) were also undertaken on the as-quenched samples to investigate the effects of compression on the formation of clusters.After quenching and compression, Cu-Mg clusters were found in the matrix and it was elucidated that the formation of clusters was triggered by pressing. The volume fraction of clusters was found to be correlated to the strain applied: the higher the strain, the higher the volume fraction.After ECAP, the microstructure was constituted of long nanocrystalline bands separated by large undeformed grains for the samples containing only clusters before deformation, while the presence of S phase, prior to ECAP, lead to microstructures constituted of both coarse and refined zones distributed homogeneously throughout the sample. Although the samples presented clearly different microstructures after ECAP, implying that different strengthening mechanisms were active, the yield strength was found to lie above 500 MPa. The yield strength of the ECAP processed samples was modelled by superposing the different strengthening mechanisms altogether and by inputting the microstructural parameters coming from characterisation in the model. It was demonstrated that a very good correlation existed between the modelled and experimental yield strength values
Zemaryalai, Khatera. "Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4461.
Повний текст джерелаKoç, Gamze [Verfasser], Annegret H. [Akademischer Betreuer] Thieken, Attila [Akademischer Betreuer] Çiner, Annegret H. [Gutachter] Thieken, Attila [Gutachter] Çiner, and Johann [Gutachter] Stötter. "A comprehensive analysis of severe flood events in Turkey : event documentation, triggering mechanisms and impact modelling / Gamze Koç ; Gutachter: Annegret H. Thieken, Attila Çiner, Johann Stötter ; Annegret H. Thieken, Attila Çiner." Potsdam : Universität Potsdam, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517853.
Повний текст джерелаTavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
Повний текст джерелаThe Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.
Повний текст джерелаOs polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanhos de alto peso molecular contendo nitrogénio, designados de melanoidinas. As melanoidinas do café apresentam diversas atividades biológicas e efeitos benéficos para a saúde. No entanto, a sua estrutura exata e os mecanismos envolvidos na sua formação permanecem desconhecidos, bem como a relação estrutura-atividade biológica. A utilização de sistemas modelo e a análise por espectrometria de massa permitem obter uma visão global e, simultaneamente, detalhada das modificações estruturais nos polissacarídeos do café promovidas pela torra, contribuindo para a elucidação das estruturas e mecanismos de formação das melanoidinas. Com base nesta tese, oligossacarídeos estruturalmente relacionados com a cadeia principal das galactomananas, (β1→4)-Dmanotriose (Man3), e as cadeias laterais das arabinogalactanas, (α1→5)-Larabinotriose (Ara3), isoladamente ou em misturas com ácido 5-Ocafeoilquínico (5-CQA), o ácido clorogénico mais abundante nos grãos de café verde, e péptidos compostos por tirosina e leucina, usados como modelos das proteínas, foram sujeitos a tratamento térmico a seco, mimetizando o processo de torra. A oxidação induzida por radicais hidroxilo (HO•) foi também estudada, uma vez que estes radicais parecem estar envolvidos na modificação dos polissacarídeos durante a torra. A identificação das modificações estruturais induzidas por tratamento térmico e oxidativo dos compostos modelo foi feita por estratégias analíticas baseadas principalmente em espectrometria de massa, mas também em cromatografia líquida. A cromatografia de gás foi usada na análise de açúcares neutros e ligações glicosídicas. Para validar as conclusões obtidas com os compostos modelo, foram também analisadas amostras de polissacarídeos do café obtidas a partir de resíduo de café e café instantâneo. Os resultados obtidos a partir dos oligossacarídeos modelo quando submetidos a tratamento térmico (seco), assim como à oxidação induzida por HO• (em solução), indicam a ocorrência de despolimerização, o que está de acordo com estudos anteriores que reportam a despolimerização das galactomananas e arabinogalactanas do café durante a torra. Foram ainda identificados outros compostos resultantes da quebra do anel de açúcares formados durante o tratamento térmico e oxidativo da Ara3. Por outro lado, o tratamento térmico a seco dos oligossacarídeos modelo (individualmente ou quando misturados) promoveu a formação de oligossacarídeos com um maior grau de polimerização, e também polissacarídeos com novos tipos de ligações glicosídicas, evidenciando a ocorrência de polimerização através reações de transglicosilação não enzimática induzidas por tratamento térmico a seco. As reações de transglicosilação induzidas por tratamento térmico a seco podem ocorrer entre resíduos de açúcares provenientes da mesma origem, mas também de origens diferentes com formação de estruturas híbridas, contendo arabinose e manose como observado nos casos dos compostos modelo usados. Os resultados obtidos a partir de amostras do resíduo de café e de café instantâneo sugerem a presença de polissacarídeos híbridos nestas amostras de café processado, corroborando a ocorrência de transglicosilação durante o processo de torra. Além disso, o estudo de misturas contendo diferentes proporções de cada oligossacarídeo modelo, mimetizando regiões do grão de café com composição distinta em polissacarídeos, sujeitos a diferentes períodos de tratamento térmico, permitiu inferir que diferentes estruturas híbridas e não híbridas podem ser formadas a partir das arabinogalactanas e galactomananas, dependendo da sua distribuição nas paredes celulares do grão e das condições de torra. Estes resultados podem explicar a heterogeneidade de estruturas de melanoidinas formadas durante a torra do café. Os resultados obtidos a partir de misturas modelo contendo um oligossacarídeo (Ara3 ou Man3) e 5-CQA sujeitas a tratamento térmico a seco, assim como de amostras provenientes do resíduo de café, mostraram a formação de compostos híbridos compostos por moléculas de CQA ligadas covalentemente a um número variável de resíduos de açúcar. Além disso, os resultados obtidos a partir da mistura contendo Man3 e 5-CQA mostraram que o CQA atua como catalisador das reações de transglicosilação. Por outro lado, nas misturas modelo contendo um péptido, mesmo contendo também 5-CQA e sujeitas ao mesmo tratamento, observou-se uma diminuição na extensão das reações transglicosilação. Este resultado pode explicar a baixa extensão das reações de transglicosilação não enzimáticas durante a torra nas regiões do grão de café mais ricas em proteínas, apesar dos polissacarídeos serem os componentes maioritários dos grãos de café. A diminuição das reações de transglicosilação na presença de péptidos/proteínas pode dever-se ao facto de os resíduos de açúcares redutores reagirem preferencialmente com os grupos amina de péptidos/proteínas por reação de Maillard, diminuindo o número de resíduos de açúcares redutores disponíveis para as reações de transglicosilação. Além dos compostos já descritos, uma diversidade de outros compostos foram formados a partir dos sistemas modelo, nomeadamente derivados de desidratação formados durante o tratamento térmico a seco. Em conclusão, a tipificação das modificações estruturais promovidas pela torra nos polissacarídeos do café abre o caminho para a compreensão dos mecanismos de formação das melanoidinas e da relação estrutura-atividade destes compostos.
Polysaccharides are the major components of green and roasted coffee beans, and coffee brew. The most abundant ones are galactomannans, followed by arabinogalactans. During the roasting process, galactomannans and arabinogalactans undergo structural modifications that are far to be completely elucidated due to their diversity and complexity of the compounds formed. During the roasting process, galactomannans and arabinogalactans react with proteins, chlorogenic acids, and sucrose, originating high molecular weight brown compounds containing nitrogen, known as melanoidins. Several biological activities and beneficial health effects have been attributed to coffee melanoidins. However, their exact structures and the mechanisms involved in their formation remain unknown, as well as the structure-biological activity relationship. The use of model systems and mass spectrometry analysis allow to obtain an overall view and, simultaneously, detailed, of the structural modifications in coffee polysaccharides promoted by roasting, contributing to the elucidation of the structures and formation mechanisms of melanoidins. Based on this thesis, oligosaccharides structurally related to the backbone of galactomannans, (β1→4)-D-mannotriose, and the side chains of arabinogalactans, (α1→5)-Larabinotriose, alone or in mixtures with 5-O-caffeoylquinic acid, the most abundant chlorogenic acid in green coffee beans, and dipeptides composed by tyrosine and leucine, used as models of proteins, were submitted to dry thermal treatments, mimicking the coffee roasting process. The oxidation induced by hydroxyl radicals (HO•) was also studied, since these radicals seem to be involved in the modification of the polysaccharides during roasting. The identification of the structural modifications induced by thermal and oxidative treatment of the model compounds was performed mostly by mass spectrometry-based analytical strategies, but also using liquid chromatography. Gas chromatography was used in the analysis of neutral sugars and glycosidic linkages. To validate the conclusions achieved with the model compounds, coffee polysaccharide samples obtained from spent coffee grounds and instant coffee were also analysed. The results obtained from the model oligosaccharides when submitted to thermal treatment (dry) or oxidation induced by HO• (in solution) indicate the occurrence of depolymerization, which is in line with previous studies reporting the depolymerization of coffee galactomannans and arabinogalactans during roasting. Compounds resulting from sugar ring cleavage were also formed during thermal treatment and oxidative treatment of Ara3. On the other hand, the dry thermal treatment of the model oligosaccharides (alone or when mixed) promoted the formation of oligosaccharides with a higher degree of polymerization, and also polysaccharides with new type of glycosidic linkages, evidencing the occurrence of polymerization via non-enzymatic transglycosylation reactions induced by dry thermal treatment. The transglycosylation reactions induced by dry thermal treatment can occur between sugar residues from the same origin, but also of different origins, with formation of hybrid structures, containing arabinose and mannose in the case of the model compounds used. The results obtained from spent coffee grounds and instant coffee samples suggest the presence of hybrid polysaccharides in these processed coffee samples, corroborating the occurrence of transglycosylation during the roasting process. Furthermore, the study of mixtures containing different proportions of each model oligosaccharide, mimicking coffee bean regions with distinct polysaccharide composition, subjected to different periods of thermal treatment, allowed to infer that different hybrid and non-hybrid structures may be formed from arabinogalactans and galactomannans, depending on their distribution in the bean cell walls and on roasting conditions. These results may explain the heterogeneity of melanoidins structures formed during coffee roasting. The results obtained from model mixtures containing an oligosaccharide (Ara3 or Man3) and 5-CQA and subjected to dry thermal treatment, as well as samples derived from spent coffee grounds, showed the formation of hybrid compounds composed by CQA molecules covalently linked to a variable number of sugar residues. Moreover, the results obtained from the mixture containing Man3 and 5-CQA showed that CQA acts as catalyst of transglycosylation reactions. On the other hand, in the model mixtures containing a peptide, even if containing 5-CQA and subjected to the same treatment, it was observed a decrease in the extent of transglycosylation reactions. This outcome can explain the low extent of non-enzymatic transglycosylation reactions during roasting in coffee bean regions enriched in proteins, although polysaccharides are the major components of the coffee beans. The decrease of transglycosylation reactions in the presence of peptides/proteins can be related with the preferential reactivity of reducing residues with the amino groups of peptides/proteins by Maillard reaction, decreasing the number of reducing residues available to be directly involved in the transglycosylation reactions. In addition to the compounds already described, a diversity of other compounds were formed from model systems, namely dehydrated derivatives formed during dry thermal treatment. In conclusion, the identification of the structural modifications in coffee polysaccharides promoted by roasting pave the way to the understanding of the mechanisms of formation of melanoidins and structure-activity relationship of these compounds.
Fenollosa, Artés Felip. "Contribució a l'estudi de la impressió 3D per a la fabricació de models per facilitar l'assaig d'operacions quirúrgiques de tumors." Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667421.
Повний текст джерелаLa presente tesis doctoral se ha centrado en el reto de conseguir, mediante Fabricación Aditiva (FA), modelos para ensayo quirúrgico, bajo la premisa que los equipos para obtenerlos tendrían que ser accesibles al ámbito hospitalario. El objetivo es facilitar la extensión del uso de modelos como herramienta de preparación de operaciones quirúrgicas, transformando la práctica médica actual de la misma manera que, en su momento, lo hicieron tecnologías como las que facilitaron el uso de radiografías. El motivo de utilizar FA, en lugar de tecnologías más tradicionales, es su capacidad de materializar de forma directa los datos digitales obtenidos de la anatomía del paciente mediante sistemas de escaneado tridimensional, haciendo posible la obtención de modelos personalizados. Los resultados se centran en la generación de nuevo conocimiento para conseguir equipamientos de impresión 3D multimateriales accesibles que permitan la obtención de modelos miméticos respecto a los tejidos vivos. Para facilitar la buscada extensión de la tecnología, se ha focalizado en las tecnologías de código abierto como la Fabricación por Hilo Fundido (FFF) y similares basadas en líquidos catalizables. Esta investigación se alinea dentro de la actividad de desarrollo de la FA en el CIM UPC, y en este ámbito concreto con la colaboración con el Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloque de la tesis incluye la descripción del estado del arte, detallando las tecnologías existentes y su aplicación al entorno médico. Se han establecido por primera vez unas bases de caracterización de los tejidos vivos – principalmente blandos – para dar apoyo a la selección de materiales que los puedan mimetizar en un proceso de FA, a efectos de mejorar la experiencia de ensayo de los cirujanos. El carácter rígido de los materiales mayoritariamente usados en impresión 3D los hace poco útiles para simular tumores y otras referencias anatómicas. De forma sucesiva, se tratan parámetros como la densidad, la viscoelasticidad, la caracterización de materiales blandos en la industria, el estudio del módulo elástico de tejidos blandos y vasos, la dureza de los mismos, y requerimientos como la esterilización de los modelos. El segundo bloque empieza explorando la impresión 3D mediante FFF. Se clasifican las variantes del proceso desde el punto de vista de la multimaterialidad, esencial para hacer modelos de ensayo quirúrgico, diferenciando entre soluciones multiboquilla y de mezcla en el cabezal. Se ha incluido el estudio de materiales (filamentos y líquidos) que serían más útiles para mimetizar tejidos blandos. Se constata como en los líquidos, en comparación con los filamentos, la complejidad del trabajo en procesos de FA es más elevada, y se determinan formas de imprimir materiales muy blandos. Para acabar, se exponen seis casos reales de colaboración con el HJSD, una selección de aquellos en los que el doctorando ha intervenido en los últimos años. El origen se encuentra en la dificultad del abordaje de operaciones de resección de tumores infantiles como el neuroblastoma, y en la iniciativa del Dr. Lucas Krauel. Finalmente, el Bloque 3 desarrolla numerosos conceptos (hasta 8), actividad completada a lo largo de los últimos cinco años con el apoyo de los medios del CIM UPC y de la actividad asociada a trabajos finales de estudios de estudiantes de la UPC, llegándose a materializar equipamientos experimentales para validarlos. La investigación amplia y sistemática al respecto hace que se esté más cerca de disponer de una solución de impresión 3D multimaterial de sobremesa. Se determina que la mejor vía de progreso es la de disponer de una pluralidad de cabezales independientes, a fin de capacitar la impresora 3D para integrar diversos conceptos estudiados, materializándose una posible solución. Para cerrar la tesis, se plantea cómo sería un equipamiento de impresión 3D para modelos de ensayo quirúrgico, a fin de servir de base para futuros desarrollos.
Mallangi, Siva Sai Reddy. "Low-Power Policies Based on DVFS for the MUSEIC v2 System-on-Chip." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-229443.
Повний текст джерелаNuförtiden så har multifunktionella bärbara hälsoenheter fått en betydande roll. Dessa enheter drivs vanligtvis av batterier och är därför begränsade av batteritiden (från ett par timmar till ett par veckor beroende på tillämpningen). På senaste tiden har det framkommit att dessa enheter som används vid en fast spänning och frekvens kan användas vid flera spänningar och frekvenser. Genom att byta till lägre spänning och frekvens på grund av effektbehov så kan enheterna få enorma fördelar när det kommer till energibesparing. Dynamisk skalning av spänning och frekvens-tekniker (såkallad Dynamic Voltage and Frequency Scaling, DVFS) har visat sig vara användbara i detta sammanhang för en effektiv avvägning mellan energi och beteende. Hos Imec så använder sig bärbara enheter av den internt utvecklade MUSEIC v2 (Multi Sensor Integrated circuit version 2.0). Systemet är optimerat för effektiv och korrekt insamling, bearbetning och överföring av data från flera (hälso) sensorer. MUSEIC v2 har begränsad möjlighet att styra spänningen och frekvensen dynamiskt. I detta examensarbete undersöker vi hur traditionella DVFS-tekniker kan appliceras på MUSEIC v2. Experiment utfördes för att ta reda på de optimala effektlägena och för att effektivt kunna styra och även skala upp matningsspänningen och frekvensen. Eftersom att ”overhead” skapades vid växling av spänning och frekvens gjordes också en övergångsanalys. Realtidsoch icke-realtidskalkyler genomfördes baserat på dessa tekniker och resultaten sammanställdes och analyserades. I denna process granskades flera toppmoderna schemaläggningsalgoritmer och skalningstekniker för att hitta en lämplig teknik. Genom att använda vår föreslagna skalningsteknikimplementering har vi uppnått 86,95% effektreduktion i jämförelse med det konventionella sättet att MUSEIC v2-chipets processor arbetar med en fast spänning och frekvens. Tekniker som inkluderar lätt sömn och djupt sömnläge studerades och implementerades, vilket testade systemets förmåga att tillgodose DPM-tekniker (Dynamic Power Management) som kan uppnå ännu större fördelar. En ny metod för att genomföra den djupa sömnmekanismen föreslogs också och enligt erhållna resultat så kan den ge upp till 71,54% lägre energiförbrukning jämfört med det traditionella sättet att implementera djupt sömnläge.
Seng, Shin Chen, and 施振聖. "Mechanisms of Gastric Mucosal Hemorrhagic Ulceration Induced by Arecoline-seizure : Protection by Several Drugs." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/15531626408773747925.
Повний текст джерела國立成功大學
藥理學研究所
87
Seizure is commonly and frequently found in many diseases and drug-intoxication. When seizure occurs, patients may suffer from tremor, tonic-clonic convulsion, oxidative stress and coma. These manifestations of seizure may nonspecifically damage various organs, including liver, heart, and lungs. Several chemicals, including pennicillin, kainic acid, pentylenetetrazole and cholinergic agonists also are able to induce seizures. Arecoline (ACL), one of the ingredients of betel quid chewing, possesses potent cholinergic effect. In the present study, we induced seizure by intracerebroventricular injection of graded doses of arecoline (0, 1, 3 and 10 mg/kg in 10 ml of ACSF solution) to SD rats. The present proposal is aimed to study: (1) whether seizure may influence the integrity of gastric mucosa ; and (2) the pharmacolo-gical effects of several mucosal protective drugs on gastric mucosa in seizure rats. Rats were deprived food but allowed free access to water for 24 h. Under ether anesthesia, gastric surgical procedures were performed and the stomachs were cleansed. After recoverd from anesthesia, arecoline was injected and the rats stomachs were irrigated for 2h with an acid solution containing 100mM HCl and 54 mM NaCl. The duration and scores of seizure induced by arecoline were recorded. Gastric mucosal glutathione (GSH) concentrations, histamine levels, lipid peroxide (LPO) generations as well as luminal hemoglogin contents and stomach ulcers also were determined. The results showed that (1) gastric hemorragic ulcer can be produced by central ACL- seizure in rat stomachs irrigated with an acid solution; (2) the ulcerogenesis of ACL-seizure is associated with lower mucosal GSH levels and augmentation of mucosal histamine release and LPO production; (3) seizure induced by ACL can be abolished or prevented by pre-treatment with muscarinic receptor antagonists; (4) central ACL seizure-induced gastric hemorrhagic lesions in acid perfused stomachs may at least via vagal mediation; (5) several drugs, including histamine receptor antagonists and antioxidants, are able to ameliorate gastric hemorrhagic damages during seizure in rats.
Chen, Chun-Yu, and 陳俊宇. "Mechanisms of Gastric Mucosal Hemorrhagic Ulceration in Salmonella typhimurium-infected Rats:Protection by Several Drugs." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/abtx9z.
Повний текст джерела國立成功大學
藥理學研究所
90
Salmonella species are a common pathogenic bacteria. When they enter into body, they will cause damages of many organs including liver、kidney、intestine and other important organs. Salmonella typhimurim are a kind of Salmonella species, they can infect many kinds of animals including human, poultry, livestock, experimental animals, etc. Effects of Salmonella species are often studied for many organs in human, but studies for stomach are less. Because studies for stomach are not enough, we interest in gastric effects during infection of Salmonella species. 1ml 1x109 CFU/ml Salmonella typhi- murim were injected into male Wistar rats by intravenous from femoral vein. After 21 hours, the animal were deprived of food for 24 hr to empty food from stomach. Gastric vagotomy was performed, followed by irrigation the stomachs for 3hr with a physiological acid containing 100mM HCl plus 54mM NaCl and 600mg/L pepsin. The ulcerogenic parameters including gastric acid back-diffusion, ulcer area, mucosal lipid peroxide (LPO)、glutathione (GSH) and histamine concentrations, and luminal hemoglobin (Hb) contents were determined. Our results show that a marked increase in acid back- diffusion and in hemorrhagic ulceration was found in infected rats. A significant enhancement in mucosal lipid peroxide and histamine concen- tration, and marked decrease in mucosal glutathione levels in infected rats. Because of oxygen radical and histamine played an important role, we hypothesis that several drugs including free radical scavenger, mast cell stabilizer, histamine receptor antagonist may be used during infection. Our results suggest the gastric damages will be improved after treatment of these drugs.