Дисертації з теми "Serum 25D"
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Wyatt, Candy. "Serum 25-hydroxyvitamin D concentration in relation to melanoma progress." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/62441/2/Candy_Wyatt_Thesis.pdf.
Повний текст джерелаEskandarani, Hamza A. "Isolation and characterisation of a 25Kd fibronectin-binding growth factor from bovin serum." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328548.
Повний текст джерелаYener, Mahmut Akkaş Selami. "Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri /." Isparta : SDÜ Tıp Fakültesi, 2005. http://tez.sdu.edu.tr/Tezler/TT00216.pdf.
Повний текст джерелаOrel, V. E., A. D. Shevchenko, V. O. Melnik, O. Yu Rykhalskyi, and A. V. Romanov. "Magnetic Nanotherapy by Magnetosensitive Nanocomplexes with Different Magnetic Properties of the Walker 256 Carcinosarcoma." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/42645.
Повний текст джерелаGuenther, Isabel. "The relationship between serum leptin, 25-hydroxyvitamin D₃, and body composition." Connect to this title, 2008. http://scholarworks.umass.edu/theses/196/.
Повний текст джерелаRockell, Jennifer, and n/a. "Serum 25-hydroxyvitamin D concentrations and their determinants in the New Zealand population." University of Otago. Department of Nutrition, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080929.142611.
Повний текст джерелаMorioka, Travis Y. "The association of serum 25-hydroxyvitamin D status and statin-associated musculoskeletal symptoms." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12534.
Повний текст джерелаObjectives: In this study, we investigated the relationship between serum vitamin D status and the prevalence of musculoskeletal pain among individuals on statin therapy. We hypothesized that lower serum vitamin D concentration would be associated with a higher odds of self-reported musculoskeletal pain among statin users. Background: HMG-CoA reductase inhibitors, or statins, are widely used lipid-lowering drugs that significantly reduce morbidity and mortality associated with heart disease. Statin use is associated with a higher prevalence of self-reported musculoskeletal pain in the general population. Non-blinded studies have shown improvement in statin-associated myalgia symptoms and increased tolerance to statin therapy after treatment of vitamin D deficiency. Methods: We performed secondary data analyses using the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Employing SAS and SUDAAN, we carried out logistic regression to evaluate whether vitamin D deficiency modified the relationship between statin use and musculoskeletal pain. Based on a priori assumptions, we adjusted for the effects of demographics, selected disease states, and health habits in the logistic regression model. We also explored concentration-related trends of the effect of vitamin D on musculoskeletal pain. Results: Among 5941 participants age 40 years and older, the mean serum vitamin D concentration was 23.5 ng/mL [95% Confidence Interval (CI) 22.4, 24.2]. There was no significant difference in the mean serum vitamin D concentration between statin users (23.3 ng/mL, 95% CI 22.3, 24.3) and non-statin users (23.5 ng/mL, 95% CI 22.8, 24.2). Statin users had higher odds [adjusted odds ratio (aOR) 1.57, 95% CI 1.15, 2.13)] of self-reported musculoskeletal pain in any area (specifically including the lower extremities, lower back, upper extremities, and upper back) compared with non-users. Vitamin D deficiency was not a predictor of musculoskeletal pain (aOR 0.95, 95% CI 0.70, 1.28) in the overall sample. However, we found vitamin D deficiency to have a significant interaction with statin use for the outcome of musculoskeletal pain (p for interaction = 0.01). After stratifying the sample according to statin use, we found that compared to statin users with a vitamin D concentration of 15 ng/mL or higher, those using statins with vitamin D concentration less than 15 ng/mL demonstrated substantially higher odds of musculoskeletal pain (aOR 2.56, 95% CI 1.25, 5.25). Assessment of vitamin D as a continuous variable did not reveal a concentration-related trend between increasing vitamin D concentrations and musculoskeletal pain (p for trend = 0.4). Conclusions: After controlling for multiple confounders, our analyses showed that serum vitamin D concentration less than 15 ng/mL was associated with musculoskeletal pain among statin users. However, among those not using statins, no association between serum vitamin D levels and self-reported musculoskeletal pain was demonstrated. We showed that vitamin D deficiency modifies the relationship between statio use and musculoskeletal pain. Treating vitamin D deficiency has other proven benefits including, bone health and skeletal muscle function. Our data suggests it may be reasonable to identify and treat vitamin D deficiency in patients who report musculoskeletal pain, using statins.
Martineau, Bernadette. "Associations of Serum Vitamin D Concentrations with Dietary Patterns in US Children." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/33.
Повний текст джерелаTommie, Jessica. "Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945.
Повний текст джерелаMorris, Carolyn W. "The Relationship Between Serum 25-Hydroxyvitamin D, Vitamin D and Calcium Intake, and Adiposity in Infants." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/nutrition_theses/46.
Повний текст джерелаKrenzel, Eileen Susan. "Identification of fatty acid and bilirubin binding sites on human serum albumin by 2D-NMR spectroscopy." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12457.
Повний текст джерелаIn circulation human serum albumin (HSA) is the principal carrier for endogenous lipophilic compounds, primarily non-esterified long chain fatty acids (FA). Since FA bind multiple binding sites with varying affinities, it would be useful to probe the relative affinities for FA binding sites with a method that distinguishes individual binding sites. NMR spectroscopy is a powerful approach for studying interactions of FA with HSA and FA-competitive drugs. In the physiologically relevant solution state, 2D-NMR provides a unique view of HSA-ligand binding in a site-specific manner. Here we show nine, well-resolved peaks in 1H-13C-NMR spectra of 18-13C-oleic acid (OA)/HSA complexes. Different NMR signals arise, representing FA bound at different sites throughout the protein, with the varying intensities corresponding to the different relative affinities of HSA for OA. This investigation probes the site-specific FA binding sites with four approaches: (i) observation of order of filling with increasing FA molar ratios to HSA; (ii) addition of FA acceptors to observe the dissociation of FA from HSA; (iii) addition of drugs known to bind to low affinity FA sites; and (iv) development and use of HSA mutants that disrupt the binding of FA at high affinity sites. From the order of filling, the three highest affinity-binding sites are clearly differentiated from the six lower/medium affinity-binding sites at the physiologically relevant FA:HSA molar ratio- 4:1 . Methyl-β-cyclodextrin (MβCD) extracted FA from individual sites, in a concentration dependent manner, with the highest concentrations removing FA from the highest affinity sites. Relative affinities determined as above were consistent with the binding of drugs to previously defined primary drug binding sites, which displaced bound FA from specific lower affinity sites. HSA mutants were successfully expressed and purified, but FA binding to these proteins did not yield interpretable data. The other aim of this study was to identify the binding location of bilirubin on HSA, for it remains elusive despite intensive study. Unlabeled bilirubin competition suggested binding at primary drug binding sites, while directly probing the bilirubin-binding site with 13C-bilirubin analogs suggested binding in subdomain IB. These studies provide a methodological approach for further analysis of site-specific binding on HSA.
Frings, Christina Maria. "Bedeutung von Zytokinen in Serum und Atemkondensat bei Patienten vor und nach Lungenresektion wegen eines Bronchialkarzinoms - eine Pilotstudie." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-54492.
Повний текст джерелаPereira, Cristiane de Pauli. "Avaliação clínica e da hepatotoxicidade do veneno de Crotalus durissus terrificus e do soro antiofídico em ratos Wistar." Universidade do Oeste Paulista, 2012. http://bdtd.unoeste.br:8080/tede/handle/tede/258.
Повний текст джерелаThis study evaluated the effects of the venom from Crotalus durissus terrificus and snakebite serum on the clinical signs and liver function in 120 Wistar rats by performing physical examinations, laboratory and histopathology tests. The animals were divided into four experimental groups of thirty animals in each group. The control group (C) - received only solution of sodium chloride 0.9%; Group venom (V) - received 1mg/kg venom; Group snakebite serum (S) - received the indicated dose snakebite serum to neutralize the poison; Poison and serum group (VS) - received venom and the snakebite serum six hours later. The clinical evaluation and specimen obtained for laboratory and histological examinations were performed at time 2 hours, 8 hours and 24 hours in all groups. It was observed for the S Group elevation of serum enzyme alkaline phosphatase (FA), inflammatory reaction, changes in Kupffer cells, necrosis and hyaline degeneration; Group V heart rate decrease over time, increase in rectal temperature (TR), increased FA, increase of serum aspartate aminotransferase (AST), inflammatory infiltrate, changes in Kupffer cells, necrosis and hyaline degeneration; Group VS increased TR and also respiratory rate, elevated serum FA, AST and alanine aminotransferase (ALT), inflammatory reaction, changes in Kupffer cells, necrosis and hyaline degeneration. The results indicate that the venom and snakebite serum alter the clinical parameters and cause liver damage at the doses and times studied. However, further studies with the venom and antivenom to be able to understand the effect of time and changes in the percentage contribution of hepatotoxicity in serum isolated. In addition, to investigate the need for additional treatments to protect the liver.
Este estudo avaliou os efeitos hepatotóxicos do veneno de Crotalus durissus terrificus e soro antiofídico em 120 ratos Wistar, através da realização de exames físico, laboratorial e histopatológico. Os animais foram divididos em quatro grupos experimentais, com trinta animais em cada grupo, sendo: grupo controle (C) - recebeu solução de cloreto de sódio 0,9%; grupo veneno (V) - recebeu veneno crotálico 1mg/Kg; grupo soro antiofídico (S) - recebeu soro antiofídico na dose indicada para neutralizar o veneno; grupo veneno e soro (VS) - recebeu veneno crotálico e após 6 horas o soro antiofídico. A avaliação clínica e a colheita de material para exames laboratorial e histopatológico do fígado foram realizadas nos momentos 2 horas (n=10), 8 horas (n=10) e 24 horas (n=10) para todos os grupos. Observou-se para o grupo S elevação sérica da enzima fosfatase alcalina (FA), infiltrado inflamatório, alterações nas células de Kupffer, necrose e degeneração de hialina; Grupo V diminuição da frequência cardíaca no decorrer do tempo, aumento na temperatura retal (TR), elevação da FA, elevação sérica da aspartato aminotransferase (AST), infiltrado inflamatório, alterações nas células de Kupffer, necrose e degeneração de hialina; Grupo VS aumento da TR e na frequência respiratória, elevação sérica da FA, elevação sérica da AST, elevação sérica da alanina aminotransferase (ALT), infiltrado inflamatório, alterações nas células de Kupffer, necrose e degeneração de hialina. Os resultados encontrados indicam que o veneno crotálico e o soro antiofídico, associados ou não, alteram os parâmetros clínicos e provocam danos hepáticos nas doses e momentos estudados. No entanto, são necessários novos estudos com o veneno crotálico e a soroterapia para que se possa entender o efeito do tempo nas alterações e a porcentagem de contribuição do soro isolado na hepatotoxicidade. Além disso, investigar a necessidade de tratamentos complementares para a proteção hepática.
Nilsson, Tilde. "Metodjämförelse mellan Immulite® 2000 XPi och Phadia® 250 för analys av IgE-antikroppar i serum : En studie med avseende på IgE-medierad allergi." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-71473.
Повний текст джерелаAllergy is nowadays a public health problem that’s affecting 20 % of the Swedish population. A very common allergen that is related to 40% of all the allergic cases is pollen. Allergic reactions occur when an individual is repeatedly exposed to an allergenic substance called allergene. IgE antibodies then form and bind to basophilic granulocytes and mast cells. The allergic reaction or type I hypersensitivity reaction, occurs when an allergen such as pollen comes into direct contact with IgE antibodies on mast cells or basophilic granulocytes. IgE is produced by plasma cells under the influence of CD4+ T lymphocytes. The IgE antibodies synthesized then sensitize the mast cells and basophilic granulocytes which are the most active cell types involved in allergic reactions. Allergic individuals have a higher concentration of IgE antibodies in the blood than non-allergic. Normal serum IgE concentration in non-allergic patients is <0.35 kU / L. The aim of the study was to compare two immunochemical instruments, Siemens Immulite® 2000 XPi and Thermo Fisher Phadia® 250, by analyzing 50 serum samples to detect possible presence of IgE antibodies directed against an inhalation panel and a single allergen (IgE against birch). The study material consisted of 50 patients between the ages of 18-80, 17 men (34%) and 33 women (66%). The results showed that overall the two methods yielded consistent results due to positive and negative IgE values, but the measured values of the methods lacked concordance. The analysis results from the two methods generally yielded good correlation in the analysis of specific IgE against birch (R = 0.977) but a weaker correlation in the inhalation panel analysis (R = 0.609). Man-Whitney u-test showed a significant difference in IgE analysis against birch (p = 0.0006). However, a significant difference between the IgE values of the methods against the inhalation panels (p = 0.22398) was not observed. To be able to evaluate whether Phadia® 250 could be used as an alternative to the routine method, a larger population of samples and more analytical occasions is required.
Bandzaitė, Virginija. "Vitamino D, kalcitonino ir parathormono kiekių kaita karvių kraujo serume bei reikšmė mineralinių medžiagų apykaitos procesams." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20051230_125132-51108.
Повний текст джерелаScherf, Kayla K. "Vitamin D Status of American Adults Age 18 Years and Older: National Health And Nutrition Examination Survey 2001-2002 and 2003-2004." Bowling Green, Ohio : Bowling Green State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1225454830.
Повний текст джерелаNelson, Monica. "Serum 25-Hydroxyvitamin D Response to Daily Oral Supplementation with 800 IU Cholecalciferol in Premenopausal Women Living in Maine." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/NelsonM2007.pdf.
Повний текст джерелаMilone, Cristiana. "Association between Serum Vitamin D Concentrations and Depression in the US Population: National Health and Nutrition Examination Survey, 1988-1994." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/nutrition_theses/5.
Повний текст джерелаShaikh, Nida I. "Serum Vitamin Concentrations are Associated with Metabolic Syndrome and Insulin Resistance in US Children." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/nutrition_theses/20.
Повний текст джерелаWoolard, Christopher Lee. "Identification of Potential Protein Biomarkers of Low Level Kidney Degradation." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1247498817.
Повний текст джерелаFlohr, Joshua Richard. "The effects of various sources and levels of supplemental vitamin D3 on growth performance and serum 25(OH)D3 of young pigs." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15196.
Повний текст джерелаDepartment of Animal Sciences and Industry
Jim Nelssen
Seven experiments using a total of 3,251 preweaned pigs, nursery pigs, and sows were used to determine the effects of: 1) supplemental vitamin D[subscript]3 on suckling and nursery pig growth, and maternal performance, and 2) high sulfate water, dietary zeolite and humic substance on nursery pig performance. Also, a web-based survey was developed to question pork producers and advisors of the swine industry on their knowledge of feed efficiency. Experiment 1 tested an oral dose of either; none, 40,000 or 80,000 IU vitamin D[subscript]3 given to pigs 24 to 48 h after farrowing. No differences in growth performance or bone mineralization were observed, but vitamin D[subscript]3 supplementation increased serum 25(OH)D[subscript]3 on d 10, 20, and 30, but returned to control values by d 52. Experiments 2 and 3 evaluated an oral dose of vitamin D[subscript]3 to pigs just before weaning, as well as added D[subscript]3 in nursery diets and in drinking water. There were no effects on growth performance; however, serum 25(OH)D[subscript]3 increased with all sources of vitamin D[subscript]3 supplementation. Experiment 4 evaluated if pigs had a preference to 1 of 3 dietary concentrations of vitamin D[subscript]3. Pigs ate less feed from diets containing very high levels of vitamin D[subscript]3 compared to commonly supplemented levels. Experiment 5 evaluated 3 levels of vitamin D[subscript]3 in sow diets. There were no effects on sow productivity, subsequent pig performance, or piglet bone ash content. However, increasing vitamin D[subscript]3 increased sow serum 25(OH)D[subscript]3, milk vitamin D, and pig serum 25(OH)D[subscript]3. Experiment 6 and 7 evaluated the effects of dietary zeolite and humic substances in nursery pigs drinking high sulfate water. Ultimately, pigs drinking high sulfate water had increased fecal moisture content and decreased growth performance, and feed additives evaluated were ineffective in ameliorating these negative effects. Finally, data collected from the feed efficiency survey suggest that there are knowledge gaps about practices that effect feed efficiency. Results from this survey will help extension educators better target specific industry segments with current information and provide more specific areas of future research where lack of information has been identified.
Handley, Simon Alfred. "Measurement of hepcidin-20, -22, -24, and -25 in human serum by liquid chromatography-high resolution-mass spectrometry and its clinical application." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/measurement-of-hepcidin20-22-24-and25-in-human-serum-by-liquid-chromatographyhigh-resolutionmass-spectrometry-and-its-clinical-application(469cf3da-46c9-4450-8f55-c878941a1abd).html.
Повний текст джерелаVan, Fleit William E. III. "Self-Reported Medical Conditions and Demographic, Behavioral and Dietary Factors Associated with Serum 25(OH)-Vitamin D Concentration in the US Adult Population." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/math_theses/114.
Повний текст джерелаConnell, David. "Assessment of the relationship between serum 25-hydroxyvitamin D3, human alveolar macrophage function, and in vitro and in vivo outcomes of M. tuberculosis exposure." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/50692.
Повний текст джерелаCerom, Jaqueline Lourenço. "Podem os distúrbios de fala de crianças com fissura labiopalatina serem justificadas pelas alterações das habilidades auditivas centrais?" Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/25/25143/tde-05092016-161354/.
Повний текст джерелаChildren with cleft lip and palate usually have speech-language disorders with manifestations in various aspects of communication and supply. With regard to auditing, children with cleft palate tend to have fluid buildup in the middle ear due to malfunction of the opening and closing mechanism of the Eustachian tube. The table may develop into Otitis, which is one of the most common causes of hearing loss in children up to 10 years with cleft lip and palate. This hearing loss is usually conductive type and bilateral. Normal hearing is essential for the acquisition of oral language and effective verbal communication and that deficits of the auditory system, congenital or acquired, affect the transmission and perception of sound. Any hearing loss offers sensory deprivation and may thus lead alteration in different hearing abilities.Scientific studies related to the auditory abilities in children with cleft lip and palate are increasing, however, there is a paucity of studies linking central auditory skills with speech disorders in the cleft lip and palate. Thus hypothesized dry the central auditory skills in children with cleft lip and palate who have speech disorders would be different from the skills of children with cleft lip and palate speechless change and also that could be a relationship between speech disorders related to velopharyngeal dysfunction and central auditory skills .The objective of this study is investigate the association between central auditory skills and speech disorders resulting from the velopharyngeal dysfunction (hypernasality and nasal air emission) and compensatory articulations in children with cleft palate. In this research it performed a prospective study of 45 patients, subdivided into 3 groups. All enrolled in the Craniofacial Anomalies Rehabilitation Hospital of the University of São Paulo, with operated cleft lip and palate. They were initially investigated in medical records data on the velopharyngeal dysfunction and use of compensatory articulations in order to compose the three study groups: the G1 with speech disorders resulting from the velopharyngeal dysfunction and compensatory articulations, G2 with speech disorders resulting from the velopharyngeal dysfunction But without compensatory articulations and G3 (control group) without speech disorders resulting from the velopharyngeal dysfunction and no compensatory articulations. Later the subjects underwent a peripheral audiological evaluation and auditory processing tests. The compensatory articulation was the most frequent glottal stop, followed by pharyngeal fricative and plosive average back palatal. The G1 was the group that had the highest number of subjects with altered auditory skills, followed by G2 and G3. Found statistically significant association between the group with speech disorders resulting from VPD and CA with the figure-ground skills and temporal skills. The temporal resolution skill was altered in all groups of this study.
Gironda, Carlos Condarco. "Potencial anti-erosivo de uma nova cistatina derivada da cana-de-açúcar: definindo concentrações e veículos a serem utilizados." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-01102018-164447/.
Повний текст джерелаDental erosion has a multifactorial etiology, thus, there are several preventive and therapeutic possibilities. Saliva is one of the most important biological factors involved, having a protective role against erosive challenges and contributing to the formation of the acquired enamel pellicle. The incorporation of proteins in the acquired enamel pellicle, by their addition to dental products such as mouthwashes or gels, for example, can affect its ability to protect against erosion. Preliminary experiments from our group have shown that a sugar cane-derived protein that was recently cloned, known as CaneCPI-5 has a strong interaction force with the enamel and is capable of protecting it against initial erosion. The aim of this study was to evaluate the effect of solutions or gels containing CaneCPI-5, in different concentrations, on the protection against initial enamel erosion in vitro. Bovine enamel blocks (n=150) (4X4 mm) were prepared. For each of the vehicles tested (solution or gel) 5 groups (one control, constituted by deionized water or placebo gel and four experimental) were constituted. For the solutions, the experimental groups were constituted of: 0.27% mucin + 0.5% casein, 0.025 g/L CaneCPI-5, 0.1 g/L CaneCPI-5 or 1.0 g/L CaneCPI-5. For the gels, they were: 0.27% mucin + 0.5% casein, 0.1 g/L CaneCPI-5, 1.0 g/L CaneCPI-5 or 2.0 g/L CaneCPI-5. The specimens were treated with the solutions for 2 h at 30°C under stirring or with the gels for 1 min. Stimulated saliva was collected from three volunteers and the acquired enamel pellicle was formed for 2 h. Then the specimens were incubated in a solution of 0.65% citric acid (pH = 3.4) for 1 min at 30°C under stirring. Each specimen was treated once a day for 3 days. Surface hardness analysis (SHM) was made and changes in SMH (SHM baseline - posterosion SMH; %SHC) was calculated on days 1 and 3. Data were analyzed by Kruskall-Wallis and Dunn´s tests (p<0.05). The solutions containing 0.1 and 1.0 g/L CaneCPI-5 significantly reduced %SHC when compared with the other treatments, for both experimental periods, without significant difference between them. As for the gels, similar results were obtained but only at the first day of treatment. After 3 days, the protective effect was lost. In conclusion, the treatment with solution containing 0.1g/L CaneCPI-5 seems to be a good alternative to prevent initial enamel erosion, what needs to be confirmed using experimental conditions that more closely resemble the clinical situation.
Borradale, David. "Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/26359/1/David_Borradale_Thesis.pdf.
Повний текст джерелаBorradale, David. "Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland." Queensland University of Technology, 2008. http://eprints.qut.edu.au/26359/.
Повний текст джерелаKaul, Anne [Verfasser], Nele [Akademischer Betreuer] Friedrich, Nele [Gutachter] Friedrich, and Holger [Gutachter] Schulz. "Assoziationen zwischen Serum 25-Hydroxyvitamin D und kardiopulmonaler Leistungsfähigkeit sowie Lungenfunktion und deren potentielle Mediation durch gesundheitsrelevante Einflussfaktoren / Anne Kaul ; Gutachter: Nele Friedrich, Holger Schulz ; Betreuer: Nele Friedrich." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1187444030/34.
Повний текст джерелаRiedel, Johanna Christina [Verfasser], Vanadin R. [Akademischer Betreuer] [Gutachter] Seifert-Klauss, and Marion B. [Gutachter] Kiechle. "25-Hydroxyvitamin D im Serum und Biopsieergebnisse bei Frauen mit auffälliger Mammographie / Johanna Christina Riedel ; Gutachter: Vanadin R. Seifert-Klauss, Marion B. Kiechle ; Betreuer: Vanadin R. Seifert-Klauss." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1143826132/34.
Повний текст джерелаAntonoglou, G. (Georgios). "Vitamin D and periodontal infection." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209166.
Повний текст джерелаTiivistelmä Tutkimuksen tarkoituksena oli selvittää seerumin 25-hydroksivitamiini D:n [25(OH)D, D-vitamiinin varastomuoto] ja 1,25-dihydroksivitamiini D:n [1,25(OH)2D, D-vitamiinin aktiivinen muoto] tasojen yhteyttä parodontiumin alueen infektiosairauksiin. Tulokset perustuvat kolmeen tutkimusasetelmaan: tapaus-verrokki-tutkimus (63 parodontiitti-potilasta, 30 verrokkia), interventio-tutkimus [80 tyypin 1 diabetes mellitus (T1DM) potilasta, joista 65 osallistui seurantaan parodontologisen hoidon jälkeen] ja poikittaistutkimus Terveys 2000 tutkimuksen osa-aineistossa (1262 30-49 vuotiasta tupakoimatonta ei-diabeetikkoa). Tapaus-verrokki- ja interventiotutkimuksissa tutkittiin myös seerumin parathormoonin (PTH) yhteyttä parodontaali-infektioon sekä PTH:n vaikutusta seerumin 1,25(OH)2D tasoon infektion hoidon jälkeen. D-vitamiinin ja PTH:n tasot määritettiin immunologisin menetelmin. Yhteyksiä tutkittiin käyttäen vakioituja monimuuttujamalleja. Tapaus-verrokki-tutkimuksessa yksilöt, joilla seerumin 1,25(OH)2D taso oli alhainen, kuuluivat todennäköisemmin parodontiitti- kuin verrokkiryhmään. Interventiotutkimuksen alkutilanteessa seerumin 1,25(OH)2D:n ja parodontaali-infektion vaikeusasteen välillä vallitsi tilastollisesti merkittävä käänteinen yhteys ja taso nousi merkittävästi infektion hoidon jälkeen. Myös seerumin PTH taso nousi parodontaali-infektion hoidon jälkeen; nousu oli tilastollisesti merkittävä (p = 0.016) pitkälle edennyttä parodontiittia sairastavilla. Interventiotutkimuksen tulokset viittaavat kausaaliseen yhteyteen 1,25(OH)2D:n ja parodontaali-infektion välillä. Alhainen seerumin 1,25(OH)2D pitoisuus infektion vallitessa voi selittyä sen suurella käytöllä immuunipuolustukseen infektion aikana tai lisääntyneellä hajoamisella. Tason nousu hoidon jälkeen tukee edellä mainittua. PTH on 25(OH)D:n hydroksylaation pääsäätelijä ja 1,25(OH)2D:n nousua hoidon jälkeen voi osittain selittää myös seerumin PTH tason kohoaminen. Seerumin 25(OH)D:n ja parodontaali-infektion välillä havaittu yhteys oli heikko, mutta ei täysin sulje pois 25(OH)D:n suojaavaa vaikutusta. Käänteinen yhteys löytyi vain interventiotutkimuksen alkutilanteessa T1DM potilailla. Infektion hoito ei vaikuttanut 25(OH)D tasoon. Terveys 2000 tutkimuksen osa-aineistossa havaittiin hyvän suuhygienian omaavilla jonkin verran alhaisempi määrä syventyneitä ientaskuja ylemmissä kuin alemmissa 25(OH)D kvintiileissä
Lee, Alice Ming Chin. "The role of dietary vitamin D and calcium in determining bone health and strength." Thesis, 2011. http://hdl.handle.net/2440/72062.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, 2011
Guenther, Isabel L. "The Relationship between Serum Leptin, 25-hydroxyvitamin D3, and Body Composition." 2008. https://scholarworks.umass.edu/theses/196.
Повний текст джерелаBian, Shiying. "the Relationship between Vitamin D Statuses and Young Adult Women Asthma." 2011. https://scholarworks.umass.edu/theses/568.
Повний текст джерела"Gas chromatography-mass fragmentographic analysis of serum 1[alpha], 25-dihydroxyvitamin D3." Chinese University of Hong Kong, 1991. http://library.cuhk.edu.hk/record=b5886886.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 1991.
Includes bibliographical references.
ACKNOWLEDGEMENT --- p.1
ABSTRACT --- p.2
CONTENTS
Chapter 1. --- INTRODUCTION --- p.4
Chapter 1.1 --- Discovery of vitamin D
Chapter 1.2 --- Bioavailability of vitamin D and its metabolites
Chapter 1.3 --- Metabolism of vitamin D and its metabolites
Chapter 1.4 --- Mode of action of vitamin D
Chapter 1.5 --- Vitamin D-related diseases
Chapter 2. --- METHODS OF MEASURING VITAMIN D AND ITS METABOLITES --- p.32
Chapter 2.1 --- Deproteinization
Chapter 2.2 --- Extraction
Chapter 2.3 --- Separation
Chapter 2.4 --- Quantitation
Chapter 3. --- OBJECTIVES --- p.51
Chapter 4. --- MATERIALS & METHODS --- p.52
Chapter 4.1 --- Materials
Chapter 4.2 --- General methods
Chapter 4.3 --- Blood collection
Chapter 4.4 --- Radioreceptor assay
Chapter 4.5 --- Serum treatment
Chapter 4.6 --- High Performance Liquid Chromatography (HPLC)
Chapter 4.7 --- Gas Chromatography-Mass Spectrometry (GC-MS)
Chapter 4.8 --- "Serum 1α,25-dihydroxyvitamin D3 analysis"
Chapter 4.9 --- Application of the established GC-MS method
Chapter 4.10 --- Study on hypercalcaemia of tuberculosis
Chapter 5. --- RESULTS --- p.66
Chapter 5.1 --- Analysis of vitamin D3 standard
Chapter 5.2 --- "Analysis of 1α,25-dihydroxyvitamin D3 standard"
Chapter 5.3 --- Separation of vitamin D3 metabolites
Chapter 5.4 --- "Analysis of lα,25-dihydroxyvitamin D3 in serum samples"
Chapter 5.5 --- Study on hypercalcaemia of tuberculosis
Chapter 6. --- DISCUSSIONS --- p.118
Chapter 6.1 --- Derivatization
Chapter 6.2 --- Optimization of GC-MS parameters
Chapter 6.3 --- Sample pre-treatment
Chapter 6.4 --- "GC-MS analysis of serum lα,25-dihydroxyvitamin D3"
Chapter 6.5 --- Study on hypercalcaemia of tuberculosis
Chapter 7. --- CONCLUSION --- p.129
LIST OF ABBREVIATIONS --- p.131
LIST OF FIGURES --- p.134
LIST OF TABLES --- p.137
REFERENCES --- p.139
Craveiro, Vanda Luzia Abreu. "Association of serum 25-hydroxyvitamin D concentration with pulmonary function in young adults." Master's thesis, 2017. https://hdl.handle.net/10216/105758.
Повний текст джерелаCraveiro, Vanda Luzia Abreu. "Association of serum 25-hydroxyvitamin D concentration with pulmonary function in young adults." Dissertação, 2017. https://hdl.handle.net/10216/105758.
Повний текст джерелаOmand, Jessica Ann. "Predictors of 25-hydroxyvitamin D Serum Concentrations among Non-western Immigrant Preschool Children." Thesis, 2013. http://hdl.handle.net/1807/35132.
Повний текст джерелаMarumo-Ngwenya, Kuda. "Impact of a soy feeding programmme on the nutritional status of an elderly community in Sharpeville." Thesis, 2014. http://hdl.handle.net/10352/254.
Повний текст джерелаMain Purpose of the study: To evaluate the impact of soy protein feeding intervention over a period of six months on the nutritional status of an elderly (≥60 years old) community of Sharpeville, in which poverty, household food security and malnutrition were prevalent. Methods: An experimental design that had no control group but a comparison between hypercholesterolaemic (HC) and normocholesterolaemic (NC) groups was used with 134 randomly selected elderly respondents. The first stage involved a baseline survey which determined the prevalence of risk factors for cardiovascular disease (CVD) and nutritional status among participants. Measurements included biochemical indices (serum lipids, vitamin B12, folate and homocysteine), anthropometry (weight, height and waist circumference) and dietary intake using 24h-recall and 7-day dietary diversity questionnaire. Socio-demographic information gathered from previous studies on the same subjects was used. The second stage was the preparation, formulation, and implementation of a nutrition education programme to assess its impact on nutrition knowledge after the nutrition education intervention. The nutrition education was conducted in two sections, namely an exploratory study and an experimental study. An exploratory study was conducted to assess the nutrition education needs of the elderly and was followed by the experimental study, which assessed nutrition knowledge before and after the intervention. The third stage was the implementation of the 10 grams soy protein daily feeding intervention for a period of six months and evaluation of its impact on risk factors for cardiovascular disease and on nutritional status. Sensory tests, compliance and the same measurements conducted at baseline were used at follow-up (feeding intervention). A comparison of the findings of the baseline study and follow-up study was conducted. Also to provide deeper insight into the effect of soy on the risk factors for CVD and nutritional status, respondents were further stratified into HC and NC groups based on their LDL-C levels at baseline study and results were also presented as such. The data analyses included descriptive statistics and t-tests on SPSS version 21.0. Results: From the baseline study, the dietary intake results revealed a poor dietary intake which contributed to inadequate estimated average requirements (EAR) and adequate intakes (AI) of nutrients. A mainly carbohydrate-based diet was consumed with minimal intake of dairy and legumes despite a medium dietary diversity score. The anthropometric indices at baseline indicated over-nutrition based on the reported waist circumference 97.32±10.32 (80.6%) above substantial risk of CDL, obesity (75.3%) and hypertension (56.7%), with the highest percentages for both waist circumference of substantial risk and overweight/obesity found among the women (80.9% and 79.9% respectively) and for hypertension among the men (79.1%). For the biochemical results at baseline, the prevalence of risk factors for CVD was observed as abnormal mean serum lipids such as LDL-cholesterol (3.6±1.1), HDL-cholesterol (0.73±0.4), total cholesterol:HDL-cholesterol ratio (7.9±2.9), triglyceride:HDL-cholesterol ratio (2.7±2.1) and homocysteine (17.1±9.2) in the total group. The women had high TC (5.2±1.1) indicating borderline risk of CVD as compared with men who had lower TC (4.5±0.8) and this was significantly different (p=0.049). The nutrition education programme was effective in increasing knowledge with an improvement of 14.5 percent from pre- (62.3%) to post-test (76.8%) for the total group which was statistically significant (p=0.000). The results for the soy protein feeding intervention, the dietary intake for the total group indicated a statistically significant decrease in energy intake (p=0.001), by about 20.4 percent form baseline to follow-up, while energy intake at baseline was already below the EAR. Also a statistically significant decrease was seen from baseline to follow-up for total dietary fat (p=0.004), cholesterol (p=0.008) and animal protein (p=0.000), with a statistically significant increase only on dietary folate (p=0.001) and iron (0.001). These dietary changes were also observed for the HC and NC groups after the intervention with only fat not decreasing significantly for the HC group. For the anthropometry indices, and hypertension no significant impact after the intervention for the total group and also for the HC and NC groups was observed. The biochemical results indicated a beneficial effect of the soy-based products on the following serum lipids: a significant improvement in LDL-C (p=0.000), HDL-C (p=0.000) and TC:HDL ratio (p=0.000) for the HC group while only TC:HDL ratio showed a significant improvement for the NC group after the intervention. However, high risk factors for CVD in this elderly group were still observed, with a significant decrease after the intervention of serum folate (p=0.000) below the recommended level and a significant increase in homocysteine (p=0.000) above the recommended level. Significant differences between the HC and NC groups were seen in TC, LDL-C, LDL:HDL-C ratio and TC:HDL-C ratio at the beginning of the intervention (baseline). However, at the end of the intervention (follow-up), significant differences were observed only in TC, LDL-C and homocysteine. Conclusion: Although the energy intake reduced significantly, only three of the micro-nutrients (pantothenate, Niacin and selenium) had a significant decrease between baseline and follow-up. Therefore the nutritional status of these elderly was not affected as it was also observed that there was no significant impact on anthropometric indices that took place. However this intervention had a significant impact on iron intake, which was one of the deficiencies identified amongst this elderly people from previous study. Also the nutrition education and a daily consumption of at least 10g of soy had a significant beneficial effect on LDL-C, HDL-C and TC:HDL ratio for the HC groups, thus reducing risk of CVD. Although soy had a beneficial effect on blood lipid profile no effect on hypertension was observed. The guideline of a 25g intake of soy should be encouraged as recommended by FDA as an effective cholesterol-lowering food item.
Lang, Cheng-Lin, and 郎正麟. "T cell differentiation correlates with serum 25-hydroxyvitamin D level in chronic hemodialysis patients." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06535220698309384325.
Повний текст джерела國立臺灣大學
臨床醫學研究所
99
Background The cellular and humoral immune responses in patients on chronic hemodialysis (HD) are impaired. To achieve an adequate immune response, the naïve T-cells will be differentiated to T helper cell and then to Th1 and Th2 cells after they are stimulated by pathogen. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the activated form vitamin D is widely used in HD patients with secondary hyperparathyroidism (SHPT) and also is a well known immunomodulatory agent. Here we investigated the T cells differentiation and cytokines expression in different serum 25-hydroxyvitamin D (25(OH)D) levels patients, the T cell differentiation and cytokine results after treatment with activated vitamin D in the SHPT patients, and patient’s clinical manifestation. Material and methods: 57 patients on chronic HD over 3 months were enrolled during January 1st, 2009 to June 30th, 2010 in Cardinal Tien Hospital and Yung-Ho Branch. Patients with systemic infection, malignancy, taking immunosuppressive medication and who took activated vitamin D or analogues in the past 3 months were all excluded. The peripheral blood mononuclear cells (PBMCs) and sera were collected while mid-week predialysis. The PBMCs were cultured and stimulated by mitogens in different time point. Then the T cells were triplely stained by surface and intracellular cytokine markers and the differentiation was analyzed by flow cytometry. The 25(OH)D level in the sera was detected by enzyme-linked immunosorbent assay (ELISA). The Th1 (interleukin (IL)-2 and interferon (IFN)-γ) and Th2 (IL-4 and IL-5) cytokine levels in the sera and culture supernatants were also evaluated by enzyme-linked immunosorbent assay (ELISA) methods. In the SHPT patients, we prescribed the different dosage of activated vitamin D (Calcijex®, Abbott.) according to the NKF K/DOQI guideline for 3 months. Repeated previous cell culture and ELISA exam were done after 3 months later. Patient’s outcome and clinical condition would be followed and analyzed during study period. Results We divided the patients into 2 groups (vitamin D deficiency (VDD): <20 ng/ml in vitamin D and non-vitamin D deficiency (NVDD): ≧20 ng/ml in vitamin D) according to their 25(OH)D level. In the VDD group, the Th2 cytokine (IL-4 and IL-5) were lower in the sera, and the Th1 cytokine (IL-2 and IFN-γ) were higher and Th2 cytokine (IL-4 and IL-5) were lower in the culture supernatant. Besides, the T cell differentiation was towards to Th1 type in the VDD group, but Th2 type in the NVDD group. The T cell differentiation was not influenced by biochemistry examinations, such as albumin, hematocrit, calcium, phosphate, creatinine or dialysis vintage. After treatment with activated vitamin D in the SHPT patients, the serum iPTH and 25(OH)D level were not significant difference. However, the level in Th1 cytokines was decreased and that of Th2 cytokines were both increased in the sera and the culture supernatant. The T cell differentiation was also more towards to Th2 phenotype than Th1 phenotype. The mortality cases were found with prevalent Th1 cell differentiation and vitamin D deficiency. Conclusion Our finding indicated that the T-cell differentiation is only correlated with serum 25(OH)D level. The higher vitamin D in the sera, the more prevalent in Th2 cytokines and Th2 differentiation was found. Treatment with activated vitamin D also influenced the T cell differentiation and cytokines expression in the SHPT patients. Because Th2 cell has the anti-inflammatory effect, activated vitamin D treatment may not only have therapeutic potential for secondary hyperparathyroidism, but also can improve the immune response in the chronic HD patients.
Stein, Elizabeth Michelle. "Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States." 2005. http://purl.galileo.usg.edu/uga%5Fetd/stein%5Felizabeth%5F200508%5Fms.
Повний текст джерелаMcGill, Lauren Elyse. "Serum concentration levels of 25(OH)D and injury reports in NCAA Division I football players." Thesis, 2014. http://hdl.handle.net/2152/26341.
Повний текст джерелаtext
"Maternal serum level of 25(OH)D in Hong Kong Chinese pregnant women and its relationship with pregnancy outcome." 2013. http://library.cuhk.edu.hk/record=b5549764.
Повний текст джерела共有237名單胎妊娠婦女以及62名多胎妊娠的婦女在2010年8月至2011年11月間參加本研究中的隊列研究,分別在參加研究時(<20 孕周)、24-28孕周、31-36孕周以及産後6-11周進行抽血測量血清25(OH)D以及PTH水平,同時填寫一份包括對每月攝取含維生素D的食物以及營養補充劑頻度、接受日照情況及喜好、以及肌肉不適等情況的問卷,并在24-28孕周進行75克口服葡萄糖耐量試驗。參與隊列研究的單胎孕婦在20周前、31-36孕周以及産後隨訪時接受用定量超聲測量非優勢手的橈骨遠端以及中指近掌指骨的骨質超聲速率(SoS)。在産後複查時,對其嬰兒左側腓骨中部的骨質SoS進行測量。記錄婦女各次檢查時的體重、抽血月份紫外線輻射強度的歷史記錄、以及妊娠結局。另外募集一批孕婦參加病例對照研究,比較患早產(PTB)、子癇前期(PET)、妊娠糖尿病 (GDM)以及胎兒生長受限(FGR)併發癥的婦女與對照組 (體重指數以及抽血時紫外線強度配對)的血清25(OH)D水平。
孕婦在孕期的平均25(OH)D水平在44.7 ± 12.6 至48.9 ± 17.1 nmol/l範圍,25(OH)D水平與體重指數、維生素D營養補充劑、抽血時紫外線強度以及個人對陽光的喜好情況有關,而與胎兒數量、孕次、孕周以及終止妊娠無關。
單胎妊娠的孕婦三個孕期的血清25(OH)D與PTH水平均負相關,但在多胎妊娠中,二者無明顯相關性。PTH在孕期以及産後的變化相對不受25(OH)D影響。孕婦25(OH)D的水平與孕婦肌肉酸痛癥狀、産後恢復、孕期及產褥期骨質流失以及嬰兒骨質無關。患早期PTB(< 34孕周)、PET或FGR的孕婦的血清25(OH)D比對照組低,但GDM患者的25(OH)D水平與對照組無差別。血清25(OH)D低於34.3 nmol/l者的早期早產以及子癇前期的風險增高,低於50 nmol/l者發生胎兒生長受限的風險增高。服用維生素D補充劑情況可能影響25(OH)D與FGR的關係。
總而言之,血清25(OH)D水平不足以全面完全反映孕期維生素D的情況,對預測不良妊娠結局的作用有限。
This prospective study explored the maternal serum level of 25(OH)D in Chinese pregnant women in Hong Kong and the factors affecting 25(OH)D level. It also explored the correlation between maternal 25(OH)D with PTH level, maternal musculoskeletal complaints, adverse pregnancy outcome, maternal bone turnover during pregnancy and postpartum, and the bone development of the offspring, aiming to explore and establish a normal range of 25(OH)D level in pregnancy for the Hong Kong Chinese women.
A total of 237 women with singleton pregnancy and 62 women with multiple pregnancies were recruited for the cohort study from August, 2010 to November, 2011. Maternal blood samplings for 25(OH)D and PTH measurements were performed at recruitment, 24-28 weeks, 31-36 weeks of gestation, and 6-11 weeks postpartum respectively. A questionnaire which included the monthly dietary and supplement intake of vitamin D, questions about sunlight exposure, and musculoskeletal complaints was administered on each visit. A 75g oral glucose tolerance test (OGTT) was performed on cohort cases at 24-28 weeks of gestation. Measurements of the speed of sound (SoS) at the distal one third of the maternal radius and the proximal phalanx of the third finger of the non-dominant side were performed with quantitative ultrasonography (QUS) measurement during the visits at the first and third trimesters, and postnatal period. The SoS at the left mid-shaft tibia of the offspring was determined during the postnatal visit. Maternal characteristics, ultraviolet radiation (UVR) intensity at blood sampling, and pregnancy outcome, were also recorded. Cases with pregnancy complications were recruited for case-control studies, and maternal 25(OH)D level was examined with respect to preterm birth (PTB), preeclampsia (PET), gestational diabetes (GDM), and fetal growth restriction (FGR, birthweight below the 10th percentile of the customized estimated birthweight). The controls were matched for booking body mass index (BMI) and UVR intensity at blood sampling.
The mean 25(OH)D level in ranged from 44.7 ± 12.6 to 48.9 ± 17.1 nmol/l in the three trimesters, and was related to BMI, vitamin D supplementation, UVR intensity at blood sampling, and the acceptance of sunlight exposure, but not the number of fetus, parity, gestational age, or the completion of pregnancy.
Inverse correlation between PTH and 25(OH)D were observed in singleton, but not in multiple, pregnancy. The change in maternal PTH level is found to be relatively independent from that of 25(OH)D. There was no correlation between maternal 25(OH)D level with musculoskeletal complaints, postnatal recovery, bone turnover during and after pregnancy, or the bone density of the offspring. Maternal 25(OH)D level was lower in women with early PTB ( < 34 weeks), PET, and FGR, but not for GDM. A maternal 25(OH)D level of lower than 34.3nmol/l and 50 nmol/l was associated with increased risk of early PTB, PET, and FGR respectively. But the correlation between maternal 25(OH)D level with FGR might be affected by supplementation.
In conclusion, serum level of 25(OH)D is insufficient in reflecting maternal vitamin D status and metabolism in pregnancy, and is of limited use in predicting adverse pregnancy outcome.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Hu, Zhiyang.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.
Includes bibliographical references (leaves 201-223).
Abstracts and appendixes also in Chinese.
Thesis dedication --- p.i
Acknowledgments --- p.ii
Abstract --- p.v
Abstract (Chinese) --- p.viii
List of Abbreviation --- p.x
Table of contents --- p.xiii
List of Figures --- p.xxii
List of Tables --- p.xxiv
Chapter Chapter 1: --- Literature Review --- p.1
Chapter 1.1 --- The synthesis and metabolism of vitamin D --- p.3
Chapter 1.1.1 --- The synthesis of vitamin D --- p.3
Chapter 1.1.2 --- The metabolism of vitamin D --- p.4
Chapter 1.1.3 --- Vitamin D binding protein --- p.10
Chapter 1.1.4 --- Factors related to 25(OH)D level --- p.11
Chapter 1.2 --- Function of vitamin D --- p.13
Chapter 1.2.1 --- Mechanism of vitamin D function --- p.13
Chapter 1.2.2 --- Classic function --- p.14
Chapter 1.2.3 --- Non-classic function --- p.16
Chapter 1.2.3.1 --- Immune system --- p.17
Chapter 1.2.3.2 --- Cardiovascular system --- p.18
Chapter 1.2.3.3 --- Cell proliferation and differentiation --- p.18
Chapter 1.2.3.4 --- Neurological system --- p.19
Chapter 1.2.3.5 --- Reproductive system --- p.20
Chapter 1.2.3.6 --- Fetal development --- p.21
Chapter 1.3 --- The definition of vitamin D deficiency --- p.21
Chapter 1.4 --- Vitamin D status and pregnancy --- p.24
Chapter 1.4.1 --- Alteration in vitamin D metabolism during pregnancy --- p.24
Chapter 1.4.2 --- Factors affecting maternal serum level of 25(OH)D --- p.25
Chapter 1.4.3 --- Vitamin D and bone resorption during pregnancy and lactation --- p.27
Chapter 1.4.3.1 --- Alteration of calcium metabolism, bone absorption and the role of vitamin D --- p.27
Chapter 1.4.3.2 --- Measurement of bone density in pregnant women and babies --- p.33
Chapter 1.4.4 --- Current studies on maternal vitamin D status and pregnancy outcome --- p.35
Chapter 1.4.4.1 --- Birthweight --- p.35
Chapter 1.4.4.2 --- Infection --- p.37
Chapter 1.4.4.3 --- Preterm delivery --- p.39
Chapter 1.4.4.4 --- Diabetes (DM) and gestational diabetes (GDM) --- p.39
Chapter 1.4.4.5 --- Hypertension and preeclampsia --- p.41
Chapter 1.4.4.6 --- Multiple pregnancy, muscular symptoms --- p.42
Chapter 1.4.4.7 --- Vitamin D supplementation and pregnancy outcome --- p.44
Chapter 1.5 --- Defining vitamin D deficiency in pregnancy --- p.45
Chapter 1.6 --- Objective of the study --- p.46
Chapter Chapter 2: --- Study design and methods --- p.48
Chapter 2.1 --- Case recruitment and study design --- p.48
Chapter 2.1.1 --- Longitudinal singleton study --- p.49
Chapter 2.1.2 --- Cross-sectional study --- p.50
Chapter 2.1.2.1 --- Preterm birth (PTB) --- p.51
Chapter 2.1.2.2 --- Preeclampsia (PET) --- p.51
Chapter 2.1.2.3 --- Gestational diabetes (GDM) --- p.52
Chapter 2.1.3 --- Multiple pregnancy study --- p.52
Chapter 2.2 --- Measurements --- p.53
Chapter 2.2.1 --- Hormonal analysis of serum levels of 25(OH)D and PTH --- p.53
Chapter 2.2.2 --- Calculation of monthly intake of vitamin D from diet --- p.55
Chapter 2.2.3 --- SoS measurements --- p.56
Chapter 2.2.4 --- Ultraviolet radiation strength assessment --- p.59
Chapter 2.3 --- Statistical analysis --- p.60
Chapter Chapter 3 --- Longitudinal Study on the Level of and Factors Affecting Vitamin D in Singleton Pregnancy --- p.62
Chapter 3.1 --- Introduction --- p.62
Chapter 3.2 --- Material and method --- p.63
Chapter 3.3 --- Statistics --- p.64
Chapter 3.4 --- Results --- p.65
Chapter 3.4.1 --- Demographic data of the subjects --- p.65
Chapter 3.4.2 --- Maternal levels of 25(OH)D and PTH, and the factors affecting their levels --- p.66
Chapter 3.4.2.1 --- Distribution of 25(OH)D level and PTH level in the four visits --- p.66
Chapter 3.4.2.2 --- Dietary intake of vitamin D and supplementation --- p.69
Chapter 3.4.2.3 --- Seasonality and sunlight exposure --- p.73
Chapter 3.4.2.4 --- Parity --- p.76
Chapter 3.4.3 --- Changes of maternal levels of 25(OH)D and PTH in pregnancy --- p.78
Chapter 3.4.4 --- Independent factors related to maternal 25(OH)D level in pregnancy --- p.79
Chapter 3.4.5 --- Maternal and fetal 25(OH)D level at delivery --- p.80
Chapter 3.4.6 --- Muscular symptoms and other complaints in pregnancy, pregnancy outcome, and their relationships with maternal 25(OH)D level --- p.81
Chapter 3.4.7 --- Postnatal recovery and factors related to postnatal level of 25(OH)D and PTH --- p.86
Chapter 3.4.7.1 --- Postnatal symptoms and relationship with 25(OH)D and PTH --- p.86
Chapter 3.4.7.2 --- The postnatal level of 25(OH)D and PTH in women with different feeding mode --- p.88
Chapter 3.4.7.3 --- Independent factors related to postnatal 25(OH)D and PTH level --- p.89
Chapter 3.4.7.4 --- Factors related to the change of 25(OH)D and PTH after delivery --- p.90
Chapter 3.4.8 --- Correlation between 25(OH)D with PTH in pregnancy and postnatal period --- p.91
Chapter 3.5 --- Discussion --- p.92
Chapter 3.5.1 --- 25(OH)D level in Chinese pregnant women --- p.92
Chapter 3.5.2 --- Factors related to maternal 25(OH)D level --- p.93
Chapter 3.5.2.1 --- Dietary and supplementation --- p.93
Chapter 3.5.2.2 --- Seasonality and outdoor activity --- p.96
Chapter 3.5.2.3 --- Gestational age --- p.98
Chapter 3.5.2.4 --- Age and parity --- p.98
Chapter 3.5.3 --- Relationship of 25(OH)D level in the cord blood with maternal 25(OH)D level --- p.99
Chapter 3.5.4 --- 25(OH)D level and muscular complains in pregnancy --- p.100
Chapter 3.5.5. --- Postnatal recovery and 25(OH)D level --- p.101
Chapter 3.5.6 --- PTH level in pregnancy and postnatal period --- p.101
Chapter 3.6 --- Conclusion --- p.102
Chapter Chapter 4 --- Longitudinal Study on the Relationship between Maternal 25(OH)D level with Changes of Maternal Bone Density in Pregnancy and Lactation, and Factors Affecting Bone Density of newborn Infants --- p.105
Chapter 4.1 --- Introduction --- p.105
Chapter 4.2 --- Material and method --- p.106
Chapter 4.3 --- Statistics --- p.108
Chapter 4.4 --- Results --- p.108
Chapter 4.4.1 --- Demographic data --- p.108
Chapter 4.4.2 --- Maternal bone density and the changes in pregnancy and postnatal recovery --- p.109
Chapter 4.4.2.1 --- Maternal bone density in the first trimester and related factors --- p.109
Chapter 4.4.2.2 --- Maternal bone density in the three visits --- p.109
Chapter 4.4.2.3 --- The change in maternal bone density in the three visits --- p.110
Chapter 4.4.2.4 --- Diversity in the change of bone density in pregnant women --- p.112
Chapter 4.4.3 --- Factors related to the changes in bone density --- p.114
Chapter 4.4.3.1 --- Changes between the first and the third trimesters --- p.114
Chapter 4.4.3.2 --- Change between the third trimester and postnatal visits --- p.116
Chapter 4.4.4 --- The bone density in infants and related factors --- p.120
Chapter 4.5 --- Discussion --- p.122
Chapter 4.5.1 --- Maternal bone density changes in pregnancy and postnatal period --- p.122
Chapter 4.5.2 --- Factors related to the maternal bone density changes in pregnancy and postnatal period --- p.124
Chapter 4.5.2.1 --- Initial bone density, parity, and BMI --- p.125
Chapter 4.5.2.2 --- 25(OH)D and PTH level --- p.126
Chapter 4.5.2.3 --- Supplement --- p.127
Chapter 4.5.2.4 --- Lactation --- p.128
Chapter 4.5.2.5 --- Height --- p.129
Chapter 4.5.3 --- Factors related to bone density of the infant. --- p.130
Chapter 4.5.3.1 --- Maternal 25(OH)D level --- p.130
Chapter 4.5.3.2 --- Gestational age and birthweight --- p.131
Chapter 4.5.3.3 --- Maternal bone density change --- p.131
Chapter 4.5.3.4 --- The gender of the offspring and feeding method --- p.132
Chapter 4.6 --- Conclusion --- p.133
Chapter Chapter 5 --- Maternal 25(OH)D Level in Multiple Pregnancy --- p.134
Chapter 5.1 --- Introduction --- p.134
Chapter 5.2 --- Material and method --- p.135
Chapter 5.3 --- Statistics --- p.136
Chapter 5.4 --- Results --- p.137
Chapter 5.4.1 --- Demographic data of the subjects --- p.137
Chapter 5.4.2 --- The level of 25(OH)D in multiple pregnancy and singleton pregnancy --- p.137
Chapter 5.4.3 --- Supplementation in multiple pregnancy --- p.140
Chapter 5.4.4 --- The change of maternal 25(OH)D and PTH levels in the three trimesters --- p.141
Chapter 5.4.5 --- 25(OH)D level in cord blood and its correlation with 25(OH)D level of the sibling --- p.143
Chapter 5.4.6 --- Correlation between 25(OH) with PTH in pregnancy --- p.143
Chapter 5.5 --- Discussion --- p.144
Chapter 5.5.1 --- 25(OH)D level in multiple pregnancy and singleton pregnancy --- p.144
Chapter 5.5.2 --- Supplementation in multiple pregnancy --- p.146
Chapter 5.5.3 --- Changes of maternal levels of 25(OH)D and PTH in the three trimesters in multiple pregnancy --- p.146
Chapter 5.5.4 --- The PTH/25(OH) correlation --- p.147
Chapter 5.6 --- Conclusion --- p.148
Chapter Chapter 6 --- Maternal level of 25(OH)D in complicated pregnancy --- p.150
Chapter 6.1 --- Introduction --- p.150
Chapter 6.2 --- Method --- p.153
Chapter 6.2.1 --- Preterm birth --- p.155
Chapter 6.2.2 --- Preeclampsia --- p.155
Chapter 6.2.3 --- Gestational diabetes --- p.156
Chapter 6.2.4 --- Fetal growth restriction --- p.157
Chapter 6.2.5 --- The association between 25(OH)D level with pregnancy complication --- p.158
Chapter 6.3 --- Statistics --- p.159
Chapter 6.4 --- Results --- p.160
Chapter 6.4.1 --- Setting of the cutoff values of hypovitaminosis D --- p.160
Chapter 6.4.2 --- Preterm birth --- p.160
Chapter 6.4.3 --- Preeclampsia --- p.164
Chapter 6.4.4 --- Gestational diabetes --- p.168
Chapter 6.4.4.1 --- Case-control study --- p.168
Chapter 6.4.4.2 --- Factors affecting OGTT results --- p.170
Chapter 6.4.5 --- Fetal growth restriction --- p.173
Chapter 6.5 --- Discussion --- p.179
Chapter 6.5.1 --- Adjustment for confounders for case-control study --- p.179
Chapter 6.5.2 --- PTB and 25(OH)D level --- p.181
Chapter 6.5.3 --- PET and 25(OH)D level --- p.182
Chapter 6.5.4 --- GDM and 25(OH)D level --- p.186
Chapter 6.5.5 --- FGR and 25(OH)D level --- p.189
Chapter 6.5.6 --- Defining vitamin D deficiency in pregnancy --- p.192
Chapter 6.6 --- Conclusion --- p.195
Chapter Chapter 7 --- Summary --- p.196
References --- p.201
Chapter Appendix 1 --- Antenatal questionnaire (English/Chinese) --- p.224
Chapter Appendix 2 --- Postnatal questionnaire (English/Chinese) --- p.238
Chang, Kuang-Wei. "Seasonal changes and serum 25-hydroxyvitamin D levels among community-dwelling elders who live in Boston, Massachusetts and Stockholm, Sweden." Thesis, 2017. https://hdl.handle.net/2144/26663.
Повний текст джерела吳秀珠. "Characterization of Cu, Zn, Cd, Co-containing Biomolecules in Rabbit Serum and Supplement by 2D SEC/RPLC Chromatographic Techniques coupled with ICP-MS and ESI-MS Detection." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/11640354438277429767.
Повний текст джерелаGabuza, Kwazikwakhe. "Identification of differentially expressed proteins in obese rats fed different high fat diets using proteomics and bioinformatics approaches." 2013. http://hdl.handle.net/11394/3954.
Повний текст джерелаObesity is a medical condition in which an energy imbalance leads to excessive accumulation of body fat. Obesity leads to a reduction in life expectancy through its association with chronic diseases of lifestyle. The prevalence of obesity is rapidly increasing throughout the world. It is now accepted that most cases of obesity result from an interaction between genetic and environmental factors. This rapid increase in obesity generally leads to an increase in morbidity and mortality from chronic diseases such as cardiovascular disease, type 2 diabetes, osteoarthritis and cancer of which obesity is a risk factor. There is a lack of information in molecular research to explain how obesity predisposes individuals to these diseases. Proteomics is a molecular tool and a set of techniques used to identify changes at protein level from a diseased state. This study aims to identify differentially expressed proteins in serum of obese rats fed different isocaloric diets using proteomics.