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Добірка наукової літератури з теми "SCREENED FLAVONOIDS"

Автор: Grafiati

Опубліковано: 11 вересня 2023

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Статті в журналах з теми "SCREENED FLAVONOIDS"

de Almeida, Vitor Martins, and Osvaldo Andrade Santos-Filho. "Identification of Potential Allosteric Site Binders of Indoleamine 2,3-Dioxygenase 1 from Plants: A Virtual and Molecular Dynamics Investigation." Pharmaceuticals 15, no. 9 (September 2, 2022): 1099. http://dx.doi.org/10.3390/ph15091099.

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Ligand and structure-based computational screenings were carried out to identify flavonoids with potential anticancer activity. Kushenol E, a flavonoid with proven anticancer activity and, at the same time, an allosteric site binder of the enzyme indoleamine 2,3-dioxygenase-1 (IDO1), was used as the reference compound. Molecular docking and molecular dynamics simulations were performed for the screened flavonoids with known anticancer activity. The following two of these flavonoids were identified as potential inhibitors of IDO1: dichamanetin and isochamanetin. Molecular dynamics simulations were used to assess the conformational profile of IDO1-flavonoids complexes, as well as for calculating the bind-free energies.

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Park, Seon-Joo, Varun Jaiswal, and Hae-Jeung Lee. "Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis." Antioxidants 11, no. 1 (December 27, 2021): 53. http://dx.doi.org/10.3390/antiox11010053.

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Flavonoids and carotenoids are bioactive compounds that have protective effects against depressive symptoms. Flavonoids and carotenoids are the two main types of antioxidant phytochemicals. This study investigated the association between flavonoid and carotenoid intake and depressive symptoms in middle-aged Korean females. We analyzed the mechanism of these associations using an in silico method. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II), and flavonoid and carotenoid intake were assessed using a semi-quantitative food frequency questionnaire. Using a multivariate logistic regression model, we found that flavones, anthocyanins, individual phenolic compounds, lycopene, and zeaxanthin were negatively associated with depressive symptoms. In silico analysis showed that most flavonoids have high docking scores for monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB), which are two important drug targets in depression. The results of the docking of brain-derived neurotrophic factor (BDNF) and carotenoids suggested the possibility of allosteric activation of BDNF by carotenoids. These results suggest that dietary flavonoids and carotenoids can be utilized in the treatment of depressive symptoms.

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Qi, Zengxing, Ran Zhao, Jing Xu, Yanrui Ge, Ruofan Li, and Ruili Li. "Accumulation Pattern of Flavonoids during Fruit Development of Lonicera maackii Determined by Metabolomics." Molecules 26, no. 22 (November 16, 2021): 6913. http://dx.doi.org/10.3390/molecules26226913.

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Lonicera maackii (Caprifoliaceae) is a large, upright shrub with fruits that contain many bioactive compounds. Flavonoids are common active substances in L. maackii. However, there is a dearth of information about the accumulation of these flavonoids and their possible medicinal value. We used targeted metabolomics analysis based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze five developmental stages of L. maackii fruit. A total of 438 metabolites were identified in the five developmental stages, including 81 flavonoids and derivatives. The 81 flavonoids included 25 flavones and derivatives, 35 flavonols and derivatives, two isoflavones, three cyanidins and derivatives, eight procyanidins, and eight flavanones. In addition, we outlined the putative flavonoid biosynthesis pathway and screened their upstream metabolites. More importantly, we analyzed the accumulation patterns of several typical flavones and flavonols. The results reported here improved our understanding of the dynamic changes in flavonoids during fruit development and contributed to making full use of the medicinal value of L. maackii fruit.

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Huang, Xiaolong, Guilian Sun, Qiaohong Li, and Huiqing Yan. "Transcriptome Analysis Reveals Regulatory Networks and Hub Genes in the Flavonoid Metabolism of Rosa roxburghii." Horticulturae 9, no. 2 (February 9, 2023): 233. http://dx.doi.org/10.3390/horticulturae9020233.

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Rosa roxburghii Tratt, the most popular fruit that blooms in the southwest of China, has high antioxidant properties and is rich in different flavonoids. However, the regulatory network and critical genes that regulate the flavonoid biosynthesis of R. roxburghii are still unknown. In this study, HPLC analysis revealed that total flavonoids, anthocyanins, and catechin were enriched in mature fruits, flowers, and leaves, respectively. Differentially expressed genes (DEGs) between five organs of R. roxburghii involved in flavonoid metabolism were obtained by transcriptome sequencing. A total of 1130 DEGs were identified, including 166 flavonoid pathway biosynthesis genes, 622 transcription factors (TFs), 301 transporters, and 221 cytochrome P450 proteins. A weighted gene co-expression network analysis (WGCNA) of the DEGs was conducted to construct co-expression networks. Regarding enzymes in the biosynthesis of flavonoids, cytochrome P450 CYP749A22 and CYP72A219 were highlighted in the regulation of total flavonoids of mature fruits. Anthocyanin 3-O-glucosyltransferase and F3′H were the top two critical enzymes for anthocyanin accumulation in flowers. By contrast, caffeic acid 3-O-methyltransferase, 4-coumarate-CoA ligase, and shikimate O-hydroxycinnamoyltransferase were essential for catechin accumulation in leaves. Additionally, we analyzed the eigengene network of the “black” module, which had high correlations with total flavonoids (r = 0.9, p = 5 × 10−6). There were 26 eigengenes in the “black” module, consisting of 6 flavonoid biosynthesis, 14 TFs, and 6 transporters. Among them, the transcription factors RrWRKY45 (DN142829_c1_g5), RrTCP20 (DN146443_c1_g1), and RrERF118 (DN141507_c3_g2) were screened as the hub genes, which significantly correlated with total flavonoids in R. roxburghii. The present biochemical and transcriptomic data provide insights into functional genomics for breeding R. roxburghii with flavonoid accumulation.

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Xu, Sherry L., Cathy W. C. Bi, Roy C. Y. Choi, Kevin Y. Zhu, Abudureyimu Miernisha, Tina T. X. Dong, and Karl W. K. Tsim. "Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes: A Signaling Response Mediated by Estrogen Receptor." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/127075.

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Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating neurotrophic factors were analyzed in cultured rat astrocytes. Astrocyte is a major secreting source of neurotrophic factors in the brain. Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF). The inductions were in time- and dose-dependent manners. In cultured astrocytes, the phosphorylation of estrogen receptor was triggered by application of flavonoids. The phosphorylation was blocked by an inhibitor of estrogen receptor, which in parallel reduced the flavonoid-induced expression of neurotrophic factors. The results proposed the role of flavonoids in protecting brain diseases, and therefore these flavonoids could be developed for health food supplement for patients suffering from neurodegenerative diseases.

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Xu, Haishun, Xue Dai, Xue Hu, Haizheng Yu, Ying Wang, Bingsong Zheng, Juan Xu, and Xueqian Wu. "Phylogenetic Analysis of R2R3-MYB Family Genes in Tetrastigma hemsleyanum Diels et Gilg and Roles of ThMYB4 and ThMYB7 in Flavonoid Biosynthesis." Biomolecules 13, no. 3 (March 15, 2023): 531. http://dx.doi.org/10.3390/biom13030531.

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Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is an extensively used Chinese folk herb with multiple bioactivities. Among these bioactivities, flavonoids are recognized as the representative active ingredients. We previously found an elevated accumulation of flavonoids in T. hemsleyanum under water stress; however, the mechanism remains unclear. R2R3-MYB transcription factors play vital roles in the plant response to environmental stress and the regulation of secondary metabolites. Herein, a systematic transcriptome identification of R2R3-MYB family genes under water stress in T. hemsleyanum was performed to explore their potential function in the biosynthesis of flavonoids. A total of 26 R2R3-MYB genes were identified, most of which were clustered into functional branches of abiotic stress. ThMYB4 and ThMYB7 were then screened out to be associated with the biosynthesis of flavonoids through a protein-protein interaction prediction. An expression correlation analysis based on RNA-seq further confirmed that ThMYB4 and ThMYB7 were positively related to the flavonoid biosynthetic pathway genes of T. hemsleyanum. In ThMYB4- and ThMYB7-overexpression hairy roots, it was found that the expression of ThCHS and ThCHI was significantly increased, suggesting that ThMYB4 and ThMYB7 may act as regulators in flavonoid biosynthesis. This will shed new light on the promotion of flavonoid production and the medicinal value of T. hemsleyanum by manipulating transcription factors.

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Rahayu, Dyah Utami Cahyaning, Regina Ainunnisa Hakim, Shofi Airiza Mawarni, and Andhina Rizkya Satriani. "Indonesian Cinnamon (Cinnamomum burmannii): Extraction, Flavonoid Content, Antioxidant Activity, and Stability in the Presence of Ascorbic Acid." Cosmetics 9, no. 3 (June 1, 2022): 57. http://dx.doi.org/10.3390/cosmetics9030057.

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Cinnamon (Cinnamomum burmannii) is a potential source used in cosmetics to prevent skin aging due to its flavonoids and antioxidant properties. This research aims to determine the best solvent for extracting flavonoids, to conduct a large-scale isolation of flavonoids, and to evaluate the effect of ascorbic acid and temperature on the extract’s stability for 16 weeks. Various solvents for small-scale extraction were screened based on the polarity index, and one of the best for use in large-scale maceration was selected based on the AlCl3 colorimetric flavonoid content and DPPH antioxidant activity. The stability test was performed by treating cinnamon with and without ascorbic acid at selected temperatures. This test measured physical stability, evaluated flavonoid content and antioxidant activity, and analyzed volatile and non-volatile compounds using GC-MS and LC-MS. The most excellent solvent to extract flavonoids was ethanol due to its high yield (21.50%), flavonoid content (0.01749 ± 8.0 × 10−5 mg QE/g extract), and antioxidant activity (IC50 0.0162 + 7.5 × 10−4 mg/mL). The ascorbic acid addition at both temperatures affected the stability of the pH and chemical constituents. The vast majority of the extract’s flavonoid content and antioxidant activity continued to increase until the end of the observation week. This study revealed that ethanol was the best extraction solvent, and ascorbic acid can be recommended as a stabilizer of cinnamon extract for use in cosmetics for further application.

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Ram, Baga, and Navdeep S. Bains. "Antimicrobial activity of flavonoids from in vitro tissue culture and plant parts of two plant species of Western Rajasthan." Indian Journal of Pharmaceutical and Biological Research 2, no. 02 (June 30, 2014): 18–21. http://dx.doi.org/10.30750/ijpbr.2.2.4.

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Extract of flavonoids from plant parts and callus tissues of Glinus lotoides (molluginaceae) and Psoralea odorata (fabaceae) were screened against microbes’ viz., Bacillus cerus, Escherchia coli, Salmonella typhimurium, Staphylococcus aureus and Candida albicans adopting disc diffusion method. Results were compared with the zone of inhibition produced by commercially available standard antibiotics. Maximum activity was observed in flavonoid of callus tissue as compared to plant parts of both plant species.

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Bambrana, Vanishree, Dayanand Cd, and Sheela Sr. "EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY BY FLAVONOIDS FROM PONGAMIA PINNATA LINN." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (March 1, 2017): 360. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16303.

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ABSTRACTObjective: Flavonoids from the crude seeds extract of Pongamia pinnata L., dried fruit powder of Morinda citrifolia L., bark of Mangifera indica L., andrhizome of Zingiber officinale Rosc. were screened for xanthine oxidase (XO) inhibition at different concentration. The inhibitory potential of quercetinand allopurinol were used for the determination of 50% inhibitory concentration (IC50) and Ki values.Methods: Isolation of flavonoids from the plant extracts was processed by column chromatography and tested for XO inhibitory activity in the rangeof 6-800 μg/ml.Results: The results demonstrated that optimized flavonoids extract of P. pinnata L. exhibited promising XO inhibition. P. pinnata L., M. indica L., andZ. officinale Rosc. had IC50 in the concentration of 8.74 mM, 1.09 mM, 5.4 mM and Ki 0.35 mM, 1.73 mM, 2.7 mM, respectively.Conclusion: The study showed that plant species under investigation exhibited XO inhibition by optimized flavonoid extract. P. pinnata L. indicatedpromising XO inhibition compared to other plant extracts. Flavonoids can be used as a potent inhibitor of XO an alternative to allopurinol.Keywords: Xanthine oxidase, Quercetin, Allopurinol, Pongamia pinnata, Oxidative stress.

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Krishna Kumar, H. N., and Jyoti Bala Chauh. "Phytochemical screening and anticancer activity of leaf extracts of Physalis minima." JOURNAL OF ADVANCES IN NATURAL SCIENCES 3, no. 2 (October 31, 2016): 283–87. http://dx.doi.org/10.24297/jns.v3i2.3971.

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Physalis minima a medicinally important plant of the family Solanaceae has been screened for its anticancer activity. The results of preliminary phytochemical screening of the leaf extract revealed the presence of flavonoids, alkaloids, tannins, saponins, steroids, cardiac glycosides, reducing sugars and terpenoids. Determination of total phenolic contents revealed that methanolic extract showed 78.3 mg/g of phenolic compounds. Evaluation of total flavonoid content showed 61.3 mg/g of flavonoid. It was found that the % viability of HeLa cell line & Hep2 cell line are 80% & 71.8% respectively. The percentage of growth inhibition of methanolic extract in SRB assay was found to be increase with increasing concentration against both HeLa and Hep2cell lines (68 and 58% respectively). The methanolic extract showed the strongest growth inhibitory effect on both HeLa and Hep2 cell lines (85 and 73% respectively) in MTT assay. Flavonoids have been isolated and purified from the methanolic leaf extract.

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Більше джерел

Дисертації з теми "SCREENED FLAVONOIDS"

GUPTA, KAMLENDRA. "IN-SILICO DOCKING STUDIES OF PLANT DERIVED NATURAL COMPOUNDS TO IDENTIFY POTENTIAL TARGET FOR THE TREATMENT OF EBOLA VIRUS." Thesis, 2016. http://dspace.dtu.ac.in:8080/jspui/handle/repository/15194.

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Ebola virus is a negative sense, single stranded RNA virus that leads to acute hemorrhagic fever in humans and nonhuman primates. This virus is impervious to a big portion of the known antiviral drugs and there is no effective treatment as on date for disease caused by this pathogen. Looking into its capability to create a pandemic scenario across globe, there is an ultimate need for new drugs and therapy to combat this infection. The recent study deals with the assessment of the inhibitory activity of flavonoids contrary to the four selected Ebola virus receptor proteins, using in-silico studies. The viral protein VP35 was docked with small molecules obtained from flavonoid class and its derivatives, assessed on the basis of energetics, stereochemical considerations and pharmacokinetic properties to isolate potential lead compounds. The results exposed that the top ranking screened flavonoids i.e., and shown well docking charge and binding energies in all the EBOV receptors when matched with that of the described compound. All the screened flavonoids have known antiviral activity, suitable pharmacokinetic property and are being used on human, hence can be taken as anti-Ebola treatment without the time lag for clinical trial. Ligands were identified based on the active sites and docked subsequently to find out the best ligand, 7-hydroxyflavone. This ligand has better binding energy than the all other ligands. Further, Lipinski’s filters, various others physicochemical properties and toxicity studies were also done to check the bioavailability and toxicity of the top ligands.

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Частини книг з теми "SCREENED FLAVONOIDS"

Uthman, Taofik Olatunde. "The Role of Plant Secondary Metabolites in Health Management." In Therapeutic Use of Plant Secondary Metabolites, 1–20. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050622122010004.

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Plant secondary metabolites (PSM) are bioactive compounds produced by plants for protection against predatory organisms and to attract insects for pollination.Recently, greater attention is being focused on PSM due to their perceived ability toelicit pharmacological activities, including antihypertensive, antiarrhythmic,antimalarial, anticancer, analgesic, antispasmodic, antidiabetic, and antimicrobialeffects. Therefore, many plant species are continually screened for PSM, such asalkaloids, flavonoids, terpenes, saponins, cardiac glycosides, fatty acids, steroids, andtannins with a view to exploiting them in the manufacture of drugs andpharmaceuticals. In this review, the pharmacological activities and possiblemechanisms of action of selected PSM are discussed.

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Zainal-Abidin, Rabiatul-Adawiah, and Zeti-Azura Mohamed-Hussein. "Computational Analysis of Rice Transcriptomic and Genomic Datasets in Search for SNPs Involved in Flavonoid Biosynthesis." In Recent Advances in Rice Research [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94876.

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This chapter describes the computational approach used in analyzing rice transcriptomics and genomics data to identify and annotate potential single nucleotide polymorphism (SNPs) as potential biomarker in the production of flavonoid. SNPs play a role in the accumulation of nutritional components (e.g. antioxidants), and flavonoid is one of them. However, the number of identified SNPs associated with flavonoid nutritional trait is still limited. We develop a knowledge-based bioinformatic workflow to search for specific SNPs and integration analysis on the SNPs and their co-expressed genes to investigate their influence on the gain/loss of functional genes that are involved in the production of flavonoids. Raw files obtained from the functional genomics studies can be analyzed in details to obtain a useful biological insight. Different tools, algorithms and databases are available to analyze the ontology, metabolic and pathway at the molecular level in order to observe the effects of gene and protein expression. The usage of different tools, algorithms and databases allows the integration, interpretation and the inference of analysis to provide better understanding of the biological meaning of the resutls. This chapter illustrates how to select and bring together several software to develop a specific bioinformatic workflow that processes and analyses omics data. The implementation of this bioinformatic workflow revealed the identification of potential flavonoid biosynthetic genes that can be used as guided-gene to screen the single nucleotide polymorphisms (SNPs) in the flavonoid biosynthetic genes from genome and transcriptomics data.

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