Дисертації з теми "SbyD"
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Löffelmannová, Romana. "Návrh financování revitalizace bytového domu SBD Macocha." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222794.
Повний текст джерелаBemeleit, Derk Julius. "Structural characterization of the DNA repair protein complex SbcC-SbcD of thermotoga maritima." Diss., kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8072/.
Повний текст джерелаFujii, Drielli Gomes Vital. "Aplicação de planejamento baseado na estrutura do receptor na busca de inibidores de cisteíno-proteases parasitárias (cruzaína (T. cruzi) e PCB (Leishmanioses))." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-26072018-160153/.
Повний текст джерелаNeglected diseases are caused by parasites and infectious agents and affect mainly people in poor areas being prevalent in 149 countries and causing 534,000 deaths per year. Among neglected diseases we can highlight Chagas Disease and Leishmaniasis, both have a high rate of morbidity and mortality and both are addressed in this project in the search of new drugs against a NTD. Nowadays, the search for new drugs involves the selection of biological pathways essential for parasite survival, in this class of parasites we can suggest the cysteine proteases, a proteases family present in Trypanosoma cruzi and and Leishmania ssp. In order to obtain a new agent against Neglected Disease in this work was obtained the model of the enzyme CPB2.8 of L. mexicana using the comparative modeling technique, due to the unavailability of the crystallographic structure in the Protein Data Bank (PDB). In order to refine the constructed model was performed the molecular dynamics simulation of 100ns, stabilization was achieved from 80ns. Molecular dynamics simulation was validated using the Ramachandran graph, radius of rotation graph, RMSD, hydrophobic surface area graph. The molecular interaction fields were calculated in the GRID program to cruzain, CPB2.8, cathepsin B and cathepsin L. Based on molecular interaction fields generated pharmacophoric models were constructed using information about the active site of the enzymes cruzain and CPB2.8. The pharmacophoric model of cruzain was validated by ROC curve presenting AUC value of 61%. Virtual screening was performed for both proteins and 369 compounds were obtained for cuzain and 225 compounds for CPB2.8. Docking studies of these compounds was performed in order to decrease the amount of compounds to be evaluated experimentally.
Mitchell, Sophie Lousie. "A fragment-based drug discovery approach for the development of selective inhibitors of protein kinase CK2." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278650.
Повний текст джерелаFerreira, Glaucio Monteiro. "Busca por inibidores seletivos de Sirtuína 2 de T. cruzi empregando técnicas de planejamento de fármacos baseadona estrutura do receptor." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-08032019-174942/.
Повний текст джерелаChagas disease, caused by the parasite Trypanosoma cruzi, affects between 6 and 8 million people worldwide. Also known as American trypanosomiasis, because it is considered endemic only in Latin America, but has spread to other continents due to migratory movements. It is estimated that 56,000 new cases and about 12,000 deaths from complications related to Chagas disease annually. The chemotherapy available for treatment consists of only two drugs, nifurtimox and benznidazole, however these are poorly effective in the chronic phase. These drugs also have serious adverse effects and resistance from strains of the parasite. Faced with this scenario, the need to search for new drugs against T. cruzi is imminent. For the drug planning for new antiparasitic chemotherapics, the identification and characterization of metabolic pathways essential to the survival of parasites is fundamental. Therewith, the sirtuin 2 - Silent Information Regulator 2 (Sir2) enzyme has an important role for T. cruzi infection, since Sir2 in the parasite is totally involved in its cell cycle. This is an NAD+-dependent enzyme of class III histone deacetylases, and it shows an interesting biochemical target for the development of antichagasic. The availability of Sir2 genomic sequencing allows us to use SBDD (Structure Based Drug Design) strategies in identifying drug candidates for this disease. Among the modern techniques of SBDD used, virtual screening makes it possible to identify and select potent and selective enzyme inhibitors for the chosen target. The model of the T. cruzi Sir2 enzyme was constructed using the comparative modeling technique. A molecular dynamics simulation of 200ns was performed to ascertain the stability of the obtained model. Considering the stabilization of the model from 100ns, it was validated using cluster analysis, Root-mean-square Deviation (RMSD) and hydrogen bond frequency analyzes with Cofator (NAD+) and the amino acids of the catalysis site were observed, these simulation and validation steps were performed in the DESMOND program. With the robust model, the molecular interaction fields (MIFs) were generated in the GRID program (Molecular Discovery v2.1) in order to elucidate the regions favorable to the interaction with the enzyme in relation to the physicalchemical properties of Sir2. From the MIFs favorable to Sir2 of T. cruzi it was possible to construct two pharmacophoric models, which was based on the interactions of Cofator (NAD+) and the catalysis site (Nicotinamide). It was also applied as a Virtual screening filter in the UNITY program of the SYBYL X 2.0 platform, using the ZINC15 and GSK databases. Screening resulted in the selection of 8 inhibitor candidate compounds. Six compounds were obtained from the screening, because they were considered more promising, and were tested against T. cruzi Sri2 enzyme. After the assay it was possible to evaluate the potency of 4 compounds, the most promising compound being CDMS-01 (IC50 = 39.9 µM) that will be submitted to molecular optimization processes.
Costa, J?nior Carlos Antonio Mendes da. "Especifica??es e concep??es de front-end UHF integrado e multipadr?o em tecnologia CMOS 130nm." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19680.
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Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq
O Sistema Brasileiro de Coleta de Dados Ambientais (SBCDA) ? respons?vel pela coleta e transmiss?o de dados meteorol?gicos e ambientais, utilizados por dezenas de institui??es e organiza??es nacionais. O segmento espacial do sistema, composto pelos sat?lites de coleta de dados, ? uma pe?a fundamental para seu funcionamento. Para garantir a continuidade e qualidade desses servi?os, esfor?os s?o voltados para o desenvolvimento de alternativas para a constru??o de novos sat?lites. Visando reduzir o tamanho do atual transponder brasileiro, ? proposto neste trabalho a integra??o de uma interface de r?dio frequ?ncia (do ingl?s FrontEnd) a ser embarcado nos receptores da pr?xima gera??o dos sat?lites SBCDA. O circuito ? concebido respeitando os requisistos do padr?o de coleta de dados internacional, ARGOS, e do SBCDA. Este trabalho foca, portanto, na integra??o de um amplificador de baixo ru?do e dois misturadores na faixa UHF em tecnologia CMOS padr?o. As especifica??es de projeto s?o primeiramente descritas e ent?o as topologias dos circuitos s?o escolhidas. A concep??o dos circuitos ? analisada e os seus par?metros de projeto s?o derivados. Finalmente, seu layout ? concebido e os resultados finais s?o divulgados. O chip ser? fabricado utilizando a tecnologia CMOS padr?o de 130 nm da STmicroelectronics.
The Brazilian Environmental Data Collecting System (SBCDA) collects and broadcasts meteorological and environmental data, to be handled by dozens of institutions and organizations. The system space segment, composed by the data collecting satellites, plays an important role for the system operation. To ensure the continuity and quality of these services, efforts are being made to the development of new satellite architectures. Aiming a reduction of size and power consumption, the design of an integrated circuit containing a receiver front-end is proposed, to be embedded in the next SBCDA satellite generations. The circuit will also operate under the requirements of the international data collecting standard ARGOS. This work focuses on the design of an UHF low noise amplifier and mixers in a CMOS standard technology. The specifi- cations are firstly described and the circuit topologies presented. Then the circuit conception is discussed and the design variables derived. Finally, the layout is designed and the final results are commented. The chip will be fabricated in a 130 nm technology from ST Microelectronics.
Lopez, Alejandro, and Mario Garcia. "Simulator-Based Design in Practice." Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12164.
Повний текст джерелаThe automotive field is becoming more and more complex and cars are no longer just pure mechanical artifacts. Today much more than 50 % of the functionality of a car is computerized, so, a modern car system is obviously based on mixed technologies which emphasize the need for new approaches to the design process compared to the processes of yesterday. A corresponding technology shift has been experienced in the aerospace industry starting in the late sixties and today aircraft could not fly without its computers and the pilots’ environment has turned to a so called glass cockpit with no iron-made instrumentation left. A very similar change is still going on in the automotive area.
Simulator-Based Design (SBD) refers to design, development and testing new products, systems and applications which include an operator in their operation. Simulator-Based Design has been used for decades in the aviation industry. It has been a common process in this field. SBD may be considered as a more specific application of simulation-based design, where the specific feature is a platform, the simulator itself. The simulator could consist of a generic computer environment in combination with dedicated hardware components, for instance a cockpit. This solution gives us the possibility of including the human operator in the simulation.
The name of the project is Simulator-Based Design in Practice. The purpose of this master thesis is to get a complete practice in how to use a human-in-the-loop simulator as a tool in design activities focusing on the automotive area. This application area may be seen as an example of systems where an operator is included in the operation and thus experience from the car application could be transferred to other areas like aviation or control rooms in the process industry.
During the performance of the project we have gone through the main parts of the SBD process. There are many steps to complete the whole cycle and many of them have iterative loops that connect these steps with the previous one. This process starts with a concept (product/system) and continues with a virtual prototyping stage followed by implementation, test design, human-in-the-loop simulation, data analysis, design synthesis and in the end a product/system decision. An iterative process approach makes the cycle flexible and goal oriented.
We have learnt how to use the simulator and how to perform the whole cycle of SBD. We first started getting familiar with the simulator and the ASim software and then we were trying to reduce the number of computers in the simulator and changing the network in order to find good optimization pf the computer power. The second step has been to implement a new application to the simulator. This new application is the rear mirror view and consists of a new LCD monitor and the rear view vision that must be seen in the new monitor. Finally we updated the cockpit to the new language program Action Script 3.0.
The information gathering consisted of the course Human-System interaction in the University, the introduction course to ASim software and the course of Action Script 3.0.
Aqar, Dhia Y. "Modelling and Optimization of Conventional and Unconventional Batch Reactive Distillation Processes. Investigation of Different Types Batch Reactive Distillation Columns for the Production of a Number of Esters such as Methyl Lactate, Methyl Decanoate, Ethyl Benzoate, and Benzyl Acetate using gPROMS." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17139.
Повний текст джерелаThe Higher Committee for Education Development in Iraq (HCED)
Martins, João Paulo Machado. "Triagem virtual de inibidores da enzima di-hidrofolato redutase de Schistosoma mansoni (SmDHFR)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-18102017-152832/.
Повний текст джерелаSchistosomiasis is one of morbidity\'s main causes in tropical and subtropical countries, which leads to serious socioeconomic consequences. Praziquantel and oxamniquina are the drugs currently available for treating this disease, but reports points that the parasite has been resistant to both drugs, which suggests the need for new therapeutic strategies for the treatment of this disease. However, there is little interest in the pharmaceutical industry in developing drugs against neglected tropical diseases, including schistosomiasis. Due to these factors, the present work has the general objective to use computational tools to identify SmDHFR inhibitors which could be good candidates for developing new drugs. Evaluation of the exclusive characteristics of the S. mansoni protein were performed by FASTA sequence analyses in comparison to DHFR from other organisms. In order to guarantee the selective action of these molecules against the parasite enzyme, the molecular interaction fields selective for SmDHFR were calculated and used in the construction of the pharmacophoric model, which was further used in the virtual screening of SmDHFR inhibitors. Computational studies were performed and those led us to 20 molecules with a good complementarity with the pharmacophoric model that was previously generated and with potential to be SmDHFR inhibitors.
Bergström, Frida, and Marika Björkvall. "Simulation based product development and competitiveness : How does a simulation based product development affect a company’s overall future competitiveness?" Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119830.
Повний текст джерелаDen gradvis ökande konkurrens som uppstår på mogna marknader driver företagen att finna nya sätt att konkurrera. Ju mer mogen marknaden blir desto högre blir kraven på konkurrens. För Scania har faktorn hög kvalitet tills nu betraktas som en konkurrensfördel, men utveckling sker istället mot att det kommer att vara en faktor som är nödvändig att uppfylla för att ens kunna agera på marknaden. Företag som Scania måste således utvecklas över hela organisationen. Ett sätt att tänja på gränserna för FoU och produktutveckling (PD) är, baserat på detta arbete och annan tidigare forskning, att genomföra en förändring mot en simulering baserad produktutvecklings-process (SBPD). Syftet med detta examensarbete har varit att, genom att tillämpa en quality function deployment (QFD) modell, visa effekten en SBPD-process kan ha på ökad konkurrenskraft. Genom att kombinera tidigare publicerad litteratur inom området med empiriska resultat, mestadels insamlat genom intervjuer, kunde nio komponenter som utgör en SBPD-process finnas. Dessa komponenter karakteriserades i följande kategorier: IT-infrastruktur, design, modellera och testa och organisatorisk. Beroende på graden av uppfyllnad på dessa komponenter blir den SBPD-processen mer eller mindre implementerad inom företaget. De två komponenterna som anses viktigast för Scania i form av både ökad konkurrenskraft och en eventuell övergång till en SBPD-process är Virtuell representation av produkten och processen genom hela PD-processen och Ett modellbaserat/ modelldrivet arbetssätt används. Arbetet har också visat i korrelation med tidigare publicerad litteratur, att en SBPD-process kommer att minska ledtiden och kostnaden för utveckling avsevärt och samtidigt öka kunskapen om produkten och processen. Denna studie har också visat att en SBPD-process kan förbättra både interna och externa samarbeten. Men att uppnå en sådan process där dessa konkurrens-fördelar kan vinnas kommer att påverka hela organisationen, det sätt som utveckling utförs på och också hur resurserna används. En fullt implementerad SBPD-process har visat positivt påverkan följande konkurrens faktorer; frekvens av produktlanseringar, ledtiden för utveckling, PD-processflexibilitet, innovationsgrad, anpassning av erbjudandet, samarbete med interna och externa partners, kunskap om produkter och processer, FoU kostnader, tillverkningskostnad, fokus på kundernas driftsekonomi, produktkvalitet, produktsäkerhet och miljöpåverkan av både produkten och processen. För att få en positiv inverkan på alla dessa faktorer måste alla komponenter som utgör en SBPD-process implementeras och tillämpas. Dessutom så presenteras även ett ramverk för andra företag att utvärdera effekterna en SBPD-process skulle ha på deras konkurrenskraft. Analysmodellen syftar till att vägleda företag som vill övergå till en SBPD-process. Ramverket kan ange hur en SBPD-process skulle kunna påverka företagets konkurrensstrategi men också ge vägledning om vilka komponenter som kan vara viktigare att börja implementera för att nå en konkurrenskraftig SBPD-process.
Radoux, Christopher John. "The automatic detection of small molecule binding hotspots on proteins : applying hotspots to structure-based drug design." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/275133.
Повний текст джерелаSalmaso, Veronica. "Exploring protein flexibility during docking to investigate ligand-target recognition." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3421817.
Повний текст джерелаI modelli di riconoscimento ligando-proteina si sono evoluti nel corso degli anni: dal modello chiave-serratura a quello di fit-indotto e selezione conformazionale, il ruolo della flessibilità proteica è diventato via via più importante. Capire il meccanismo di riconoscimento è di grande importanza nella progettazione di nuovi farmaci, perchè può dare la possibilità di razionalizzare l’attività di ligandi noti e di ottimizzarli. L’applicazione di tecniche computazionali alla scoperta di nuovi farmaci risale agli anni ‘80, con l’avvento del cosiddetto “Computer-Aided Drug Design”, o, tradotto, progettazione di farmaci aiutata dal computer. Negli anni sono state sviluppate molte tecniche che hanno affrontato il problema della flessibilità proteica. Questo lavoro propone una strategia per considerare la variabilità delle strutture proteiche nel docking, attraverso un approccio combinato ligand-based/structure-based e attraverso lo sviluppo di una procedura completamente automatizzata di docking incrociato. In aggiunta, viene proposta una piena esplorazione della flessibilità proteica durante il processo di legame attraverso la Dinamica Molecolare Supervisionata. L’applicazione di un algoritmo simil-tabu alla dinamica molecolare classica accelera il processo di riconoscimento dalla scala dei micro-millisecondi a quella dei nanosecondi. Nel presente lavoro è stata fatta un’implementazione di questa algoritmica per studiare il processo di riconoscimento peptide-proteina.
Wampfler, Beat. "Beziehungen zwischen klinischen Untersuchungsbefunden und Indizes abgeleitet aus dem "Single breath diagram für CO2" (SBD-CO2) bei gesunden Pferden und Patienten mit chronisch obstruktiver Bronchitis : eine Studie an 66 Pferden /." [S.l.] : [s.n.], 2000. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаHASSAN, AMAL. "FROM PROTEIN STRUCTURE TO DRUG DESIGN (DISCOVERY): TARGETING THE ION CHANNEL ASIC1 AND A PATHOGENIC VARIANT OF HUMAN GELSOLIN." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/629877.
Повний текст джерелаKnowledge of the three-dimensional structure of therapeutically relevant proteins paves the way for novel strategies in pharmacological research (such as the structure-based drug design (SBDD) method) and establishes the foundations for structural bioinformatics. In this context, during my PhD Thesis, two therapeutically relevant proteins have been studied. First, a membrane protein, Acid Sensing Ion Channel (ASIC) isoform 1, a validated target in neurodegenerative disorders, was selected. Previous studies showed that diminazene aceturate (DA) is a potent small-molecule inhibitor of ASIC channels. Here, several DA analogues were screened by molecular docking and the best binders were tested in cell-based assays to further assess their efficacy. In order to determine the inhibitory capability of the synthesized analogues in vitro on the purified protein, the expression of ASIC1 was undertaken, using different organisms of expression. The protein purification was performed in a high-throughput approach in order to recover enough protein for crystallization, with the final aim of studying the mechanism of action of DA analogs, and support the design of new, isoform-selective and brain-penetrant drugs. Secondly, the soluble protein Gelsolin (GSN), responsible for a familial degenerative disease (AGel amyloidosis) was studied. Aim of this project was to understand the impact of the D187N mutation on GSN structure and its propensity to aberrant aggregation and/or degradation. D187N GSN mutant was the first identified in man, but its crystal structure had until now eluded any characterization. Conversely, a nanobody (Nb11) was shown to protect GSN from aberrant proteolysis, but its mechanism of protection remained unclear. Here, the structure of the Nb11:D187N complex was solved at 1.9 Å resolution, enabling the characterization of the Nb11action mechanism. The structural data were complemented with biophysical and biochemical characterisations. These studies were then extended to two recently identified pathological variants of GSN (G167R and N184K).
Mason, Mark R. "The Panarchy of Peace." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1205937818.
Повний текст джерелаDriche, Khaled. "Diamond unipolar devices : towards impact ionization coefficients extraction." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAT115/document.
Повний текст джерела97% of the published climate studies articles agree with the fact that recent global warming is entirely caused by human activities. The gases emitted to produce electrical energy plus other gases rejected by cars impact considerably on the atmosphere by greenhouse effect (without referring other factors). A solution to this problem is the development of components with lower power conduction losses and higher breakdown characteristics that could be used in nuclear power plants, high power commutation cells, hybrid (electric) cars and so on.The choice of the material to reach low power conduction losses and higher breakdown is of great importance. Nowadays, silicon-based devices control about 95% of all electronic components. Silicon carbide SiC and gallium nitride GaN are at present under research and development and start to be integrated into some electronic circuits. Other materials like Ga2O3, AlN or diamond are under research for power electronic application. The last ones are known as ultra wide bandgap materials and they seem to be the required solution to low power losses. Diamond is recognized as the ultimate material for the next next-generation of power devices owing to its exceptional physical properties such as high breakdown field (>10 MV/cm) to use the device for high power control, high carrier mobility (2000 cm^2/V.s for holes) for fast switching and high frequency devices, high saturation velocity, high thermal conductivity (22 W/cm.K) for a perfect heat dissipation and low dielectric constant. Theoretically, diamond is the best semiconducting material showing the best trade-off between on-resistance and breakdown voltage. Especially, due to the incomplete ionization of the dopant, it is even more efficient at high temperature. Various diamond Schottky barrier diodes (SBDs) with good forward and reverse performances (7.7 MV/cm) were reported. In addition to SBDs, switches diamond field effect transistors (FETs) were also investigated through metal-oxide-semiconductor FETs (MOSFETs) using either an H-terminated diamond surface with high current densities in on-state or an O-terminated one with high blocking characteristics. For the high blocking voltage devices, one needs to properly terminate the edge of the electrode at the surface in order to avoid premature breakdown of the devices due to electric field crowding at the borders. In that aim, edge termination (ET) techniques are used to push the limit of the devices and reach ideal features. The obvious task before any device fabrication if the simulation part that predicts the device optimization and expected characteristics. A good device prediction requires knowledge of the material parameters. Important parameters for device breakdown in the off-state are the impact ionization coefficients. At present, several ionization coefficients were reported for diamond, however, they were extracted by fitting non-optimized structures and hence there is a lack of accuracy.In this study, two edge terminations structures for Schottky barrier diodes called field plate (FP) oxide and floating field rings were investigated. Their effectiveness in surface field distribution via electron beam induced current (EBIC) analysis was observed. In addition, normally-on FETs were fabricated and characterized, a MESFET and a reverse blocking (RB)-MESFET. The FETs exhibited a high BV, up to 3 kV and a low on-resistance. The development of transistors is inseparable from the Schottky diode since both are required to fabricate commutation cells. And finally, impact ionization coefficients for electrons were measured using EBIC for a field >0.5 MV/cm in a defect-free region. The measured values are (in a Chynoweth form) an = 971 /cm and bn = 2.39x10^6 V/cm. These values are close to the experimentally measured coefficients reported in the literature
Gerrer, Louis. "Impact du claquage progressif de l'oxyde sur le fonctionnement des composants et circuits élémentaires MOS : caractérisation et modélisation." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00631364.
Повний текст джерелаAlm, Torbjörn. "Simulator-Based Design : Methodology and vehicle display application." Doctoral thesis, Linköpings universitet, Industriell arbetsvetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8465.
Повний текст джерелаRahimova, Rahila. "Structure-based drug design of allosteric ecto-5'-nucleotidase inhibitors : application to cancer treatment." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT039.
Повний текст джерелаCancer burden still remains a major worldwide health problem. To date, several types of conventional anticancer treatments are widely used in clinical. However, the alternative effects of these treatments often leave patients impaired. Therefore, it is required to understand the unique medical needs of individual patients and to conduct effective, high–quality research focusing on the not yet identified oncotargets.The first part of my thesis is dedicated to decipher molecular basis of cN-II reaction. This study characterizes the steady state and transient state kinetics of cN-II wild type and hyperactive mutant which involved in cancer treatment resistance. Furthermore, the characterization of the rate-limiting step and reaction intermediates gave insights into the binding mechanisms and the development of small molecules inhibitors of cN-II.In the second part of this work, we aimed to investigate allosteric inhibitors of CD73 using structure-based drug design approach. In this study the suitable protein expression system was established for the production of sufficient quantities of fully active CD73. This work followed by in silico studies, including molecular dynamics, virtual screening, and hits identification and in vitro hits validations and kinetics characterizations. The cytotoxicity of the most powerful inhibitors exhibited on different cell types was determined. SAR studies gave insights into the binding mode of best compounds and function
川田, 基生. "1.新教育課程と"学校に基礎をおく教育課程開発"(教育課程分科会)(共同研究 : 総合テーマ 教育活動の総合化 : 国際理解と平和の教育を軸として)". 名古屋大学教育学部附属中学校 : 名古屋大学教育学部附属高等学校, 1991. http://hdl.handle.net/2237/4911.
Повний текст джерелаCaha, Matěj. "Modelem řízený návrh konferenčního systému." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236187.
Повний текст джерелаChen, Chih-Wei, and 陳治維. "Investigation of High Power SBD with Lateral Super Junction edge Termination." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/38213598049648927959.
Повний текст джерела國立成功大學
微電子工程研究所碩博士班
91
Schottky barrier diodes (SBDs) with low forward voltage drop (VF), low reverse leakage current (IR), low power loss and high breakdown voltage (VBD), etc., have been urgently required in electronic industry. Essentially, VF and IR of SBDs are key factors in determining the power loss of SBDs for power applications, which strongly depend on the Schottky barrier height (SBH). In general, a larger SBH would result in a lower IR but a larger VF, while a lower SBH shows an inverse situation. How to solve or release the trade-off problem between VF and IR, how to improve the breakdown voltage of SBDs to approach its theoretical value, and how to minimize the power loss of SBDs without sacrificing other device properties, are still open problems in the SBDs fabrication. In this thesis, a novel device design with a RESURF type lateral super-junction for edge termination, a novel polysilicon (poly-Si) guarding ring and related fabrication process including Boron ion implantation for IR reduction and VBD enhancement are presented to tackle the open problems mentioned above. Both theoretical and experimental studies including optimum device design and device fabrication process have been conducted in this study. Special emphasis for the theoretical study is focused on the design and simulation of edge termination with super-junction, poly-Si floating ring, guard ring, and field plate. Influence of device structural parameters used in the device geometry was investigated in detail. In this thesis, technology related to high breakdown voltage device design and fabrication process has been established. It is found that the device and fabrication technology developed in the present study could be successfully applicable to the realization of SBDs with VBD > 110V, IR < 10uA/cm2,VF < 0.5V @1A/cm2 and an adjustable SBH (0.778~0.796 V).
Bemeleit, Derk Julius [Verfasser]. "Structural characterization of the DNA repair protein complex SbcC-SbcD of Thermotoga maritima / Derk Julius Bemeleit." 2008. http://d-nb.info/990179877/34.
Повний текст джерелаLing-Hui, Liu, and 劉玲慧. "An Actoin Research of Business Curriculum Reform in a Vocatonal School:Development and Application of a SBCD." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/19159014548834998692.
Повний текст джерела國立雲林科技大學
技術及職業教育研究所碩士班
91
The purpose of this study was to develop a vocational school’s new business curriculum by applying a school-based curriculum development (SBCD) model. An action research approach was employed to conduct the study. The uniqueness of this study is that it treats a business program, instead of the whole school’s curriculum, as the study unit for curriculum reform practice. Another feature of this study is that it is a bottom-up , spontaneous-oriented curriculum reform action. The literature review shows the successive changes of business department curriculum. It also shows the theory of technological and vocational education curriculum and the developing mode. The school-based curriculum theory practice, and related methods are presented as well develops the suitable theory basis and application modes to develop a new business curriculum. Then this study applies the develop of mode to the real situation. At the final stage, the researcher examines the feasibility of the curriculum develop of mode and the effectiveness of the finding in this study by helding a conference with experts. The study takes place in the school in which researcher teaches. The participants of the study include teachers, school staffs, students and community members. Data used in the study comprises students’ questionnaires, interview records, meeting records, observation records, etc. After a thorough research and cross analysis ,this study aims to obtain objective interpretations. The six conclusions of the study are as follows. I.The successive changes of vocational business curriculum is modified with the demand of economical composition. In the 89th academic year credit curriculum structure the "school-decided curriculum" appears for the first time. It’s a new age era for school-based curriculum of vocational senior high school II.The modes that are applicable to business curriculum development in senior high vocational school are those of Lo-dah harn’s , Li-long cherng’s (APIE), Lin-chun yen, Weng-shang chin, and Yang-min rong,Huang-meng liang’s (PPDEE), and Yang-min rong’s . III.There are five stages of “the mode of school-based curriculum developing for business departments”. The five stages and they are strategy planning, curriculum planning, curriculum designing, curriculum implementation, and curriculum evaluation. IV.The purpose of the strategy planning is to organize a work team for planning curriculum of business departments, analyzing the difference between the current and future curriculum, evaluating the demands, and deciding the future features of the business departments. As for the stage of curriculum planning, it aims to establish the committee for developing business department curriculum, to set up the curriculum framework of the school-decided curriculum, including the way of implementation, teachers human resources planning of business departments, and space and facility planning. V.The practical achievement of curriculum developing contain of the decision of curriculum name after transforming (Business Information Department), goals and features of the department, 3-year curriculum flowchart, teaching outlines of some subjects, weekly teaching hours sheet. Total 13 documents and forms of all the stages are presented in this study. VI.The problems the researcher encountered in the process of the curriculum developing can be categorized into three parts: educational policy, business department curriculum development, and the design of consistent curriculum. A. ational policy (1)It’s too hasty to give subordinates the authority of curriculum planning for technological and vocational education system. (2)There’s no network system of curriculum developing B.Business department curriculum development (1)Tachers don’t have the ability to develop the curriculum. (2)Teachers don’t have enough time. (3)Teachers don’t have enthuiasm about the curriculum development, and they think that it is an extra burden besides teaching. (4)It’s hard to evaluate the quality of curriculum developing. (5)The leader of curriculum developing should possess the professional ability and persistent personality. (6)Affected by the College Entrance Exam, the curriculum developing is exam-oriented. C.Design of continued curriculum, (1)The problems caused by school-decided curriculum, (2)The problems of the required curriculum by Education Ministry only for single semester, (3)Confusion about teaching new curriculum to business department of vocational high school, such as “Case Study”. According to the conclusions mentioned above, this study offer the following suggestions I.Suggestions for the administration authorized (1)The concept of school-based curriculum has to be broadcast widely to make the senior high vocational schools prepare the curriculum developing in advance. 2)Teaches rofessional ability for curriculum developing should be developed, including a work team, seed teachers and holding continuous speech or committee for curriculum developing. (3) Teacher education institutes should emphasize on developing pre-teachers' curriculum design competence. (4) Take consideration of reducing teaching hours of senior high vocational school curriculum planning team members, which can upgrade the quality of school-decided curriculum. (5) The curriculum developing centers should have their own websites, on which it provides the relevant documents or tools to solve the problems in the process of senior high curriculum developing. II. Suggestions for vocational senior high schools (1) If the principal or assistant principal can play an aggressive role in the process of curriculum developing, it will be helpful to decrease the related resistance. (2) Encourage teachers to participate in the committees for curriculum developing or refresher courses to equip some teachers with the curriculum develop of competence. III. Suggestions for further studies (1) The further studies of the process of action research can be extended to practical teaching and the evaluation. (2) The members of school-based curriculum developing can involve parents and community members. However, the plan should be formulated cautiously in order to make the members participate willingly.
Ke, Tsung-Yu, and 柯宗佑. "A 600V AlGaN/GaN Schottky Barrier Diode(SBD)on Si Substrate with Fast Reverse Recovery Time." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/57545138488455527148.
Повний текст джерела國立中央大學
電機工程研究所
99
Lateral AlGaN/GaN Schottky Barrier Diodes (SBDs) on Si substrate have been fabricated and characterized. AlGaN/GaN hetero-junction layers were grown on 4-inch p-type Si (111) substrate with 2 ?m buffer layer. The measurement of etching pit density (EPD) of GaN films on Si substrate is about 1.92×109 cm-2 by atomic force microscopy (AFM). The full width at half maximum value (FWHM) of x-ray diffraction rocking curve for the GaN film on Si (111) substrate is 536 arc-sec (002 reflection), which is related to the screw type dislocation and resulted leakage current. The Hall measurement showed the mobility of 1430 cm2 /V-s with a sheet carrier density of 9.8?1012 cm-2 for the AlGaN/GaN structure across the wafer. The AlGaN/GaN SBDs were implemented by Ti/Al/Ni/Au Ohmic and Ni/Au Schottky contacts. The Ohmic contacts were deposited on both side of Schottky contact with equal distance. The Schottky-to-Ohmic contact distance (LGS) was varied from 10 to 30 ?m in this study. The specific on-state resistance (RON) was 1.3 m?-cm2, while the forward turn-on voltage was 1.4 V at the current density of 100 A/cm2 for device with LGS = 10 ?m. The measured reverse breakdown voltage (VB) at room temperature was up to 600 V without edge terminal scheme. The measured VB is not function of LGS, which mainly depends on the buffer layer structure. The figure-of-merit is defined (VB)2/RON, that was 277 MWcm-2. And reverse recovery time was < 10 ns for device (without package) switched from a forward current density of ~720 A/cm2 (1 A) to a reverse bias of 30 V with di/dt of 100 A/?s.
Aqar, D. Y., Nejat Rahmanian, and Iqbal M. Mujtaba. "Integrated Batch Reactive Distillation Column Configurations for Optimal Synthesis of Methyl Lactate." 2016. http://hdl.handle.net/10454/8802.
Повний текст джерелаAlthough batch reactive distillation process outperforms traditional reactor-distillation processes due to simultaneous reaction and separation of products for many reaction systems, synthesis of Methyl lactate (ML) through esterification of lactic acid (LA) with methanol in such process is very challenging due to difficulty of keeping the reactants together when one of the reactants (in this case methanol) has the lowest boiling point than the reaction products. To overcome this challenge, two novel reactive distillation column configurations are proposed in this work and are investigated in detail. These are: (1) integrated conventional batch distillation column (i-CBD) with recycled methanol and (2) integrated semi-batch and conventional batch distillation columns (i-SBD) with methanol recovery and recycle. Performances of each of these configurations are evaluated in terms of profitability for a defined separation task. In i-SBD column, an additional constraint is included to avoid overflow of the reboiler due to continuous feeding of methanol into the reboiler as the reboiler is initially charged to its maximum capacity. This study clearly indicates that both integrated column configurations outperform the traditional column configurations (batch or semi-batch) in terms of batch time, energy consumption, conversion of LA to ML, and the achievable profit.
Aqar, D. Y., Nejat Rahmanian, and Iqbal M. Mujtaba. "Synthesis of methyl decanoate using different types of batch reactive distillation systems." 2017. http://hdl.handle.net/10454/11701.
Повний текст джерелаMethyl Decanoate (MeDC) is a Fatty Acid Methyl Ester (FAME) and is an important chemical compound with global production of 31 million tons per year. However, synthesis of methyl decanoate (MeDC) via esterification of Decanoic Acid (DeC) with methanol by reactive distillation is operationally challenging due to difficulty of keeping the reactants together in the reaction zone as methanol being the lightest component in the mixture can separate itself easily form the other reactant deteriorating significantly the conversion of DeC using either conventional batch or continuous distillation column. This is probably the main reason for not applying the conventional route for MeDC synthesis. Whether Semi-batch Distillation column (SBD) and the recently developed Integrated Conventional Batch Distillation column (i-CBD) offer the possibility of revisiting such chemical reactions for the synthesis of MeDC is the focus of this paper. The minimum energy consumption (Qtot) as the performance measure is used to evaluate the performances of each of these reactive column configurations for different range of methyl decanoate purity and the amount of product. It is observed that the use of i-CBD column provides much better performance than SBD column in terms of the production time and the maximum energy savings when excess methanol is used in the feed. However, the SBD column is found to perform better than the i-CBD column when both reactants in the feed are in equal amount. Also, the optimization results for a given separation task show that the performance of two-reflux intervals strategy is superior to the single-reflux interval in terms of operating batch time, and energy usage rate in the SBD process at equimolar ratio.
Lim, Jang-Kwon. "Simulation and Electrical Evaluation of 4H-SiC Junction Field Effect Transistors and Junction Barrier Schottky Diodes with Buried Grids." Doctoral thesis, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-173340.
Повний текст джерелаKiselkarbid (SiC) har en högre genombrottsfältstyrka än kisel, vilket möjliggör tunnare och mer högdopade driftområden jämfört med kisel. Följaktligen kan förlusterna reduceras jämfört med kiselbaserade omvandlarsystem. Dessutom tillåter SiC drift vid temperatures upp till 250 oC. Dessa utsikter gör att SiC anses vara halvledarmaterialet för moderna effekthalvledarkomponenter för hög verkningsgrad, hög temperature och hög kompakthet. Förutom materialegenskaperna är också komponenttypen avgörande för att bestämma systemets prestanda. Jämfört med SiC MOSFETen och bipolärtransistorn i SiC är SiC JFETen en mycket lovande component, eftersom den är spänningsstyrd och saknar tillförlitlighetsproblem med oxidskikt. Dess kanal styrs an en PNövergång. Emellertid är dagens JFETar inte optimerade med hänseende till on-state resistans, styrbarhet av tröskelspänning och Miller-kapacitans. I denna avhandling introduceras state-of-the-art SiC JFETar med buried-grid (BG) teknologi. Denna åstadkommes genom epitaxi och etsningsprocesser. Medelst simulering undersöks nya concept för normally-on och normally-off BG JFETar med blockspänningen 1200 V. Såvä statiska som dynamiska egenskper undersöks. Dessutom görs två fallstudier vad avser totalförluster på systemnivå. Dessa undersökningar kan vara värdefulla för en konstruktör för att till fullo utnyttja fördelarna av komponenterna. Dessutom kan resultaten från undersökningarna användas som komponentmodeller och anvisningar vad gäller switch-egenskaper. BG konceptet som använts för JFETar har också använts för vidareutveckling av så kallade JBS-dioder. Speciellt ger denna konstruktion stora fördelar vid höga temperature genom en effektiv skärmning av Schottkyövergången mot höga elektriska fält. Genom simuleringar har komponentstrukturer med implanterade och epitaxiella grids jämförst med hänseende till tröskelspänning, genombrottspänning och maximalt elektriskt fält vid Schottky-övergången. Resultaten visar att den epitaxiella varianten kan vara mer effektiv än den implanterade vid höga temperaturer. För att realisera detta concept optimerades en komponent med implanterat grid med hjälp av simuleringar. Denna component tillverkades sedan och verifierades genom experiment. BG JBS-dioden visar tydligt att läckströmmen är fyra storleksordningar lägre än för en ren Schottky-diod vid 175 oC, och två till tre storleksordningar lägre än för kommersiella JBS-dioder. Slutligen utvärderas kommersiella vertical trench-JFETar bade genom simuleringar och experiment, eftersom det är viktigt att bestämma gränserna för existerande JFETar och studera parallelkoppling. Speciellt studeras inverkan av obestämda parametrar och kretsens konfigurering på switchegenskaperna. Arbetet utförs bade genom simuleringar och experiment.
QC 20150915
Adiga, Aniruddha. "Sparsity Motivated Auditory Wavelet Representation and Blind Deconvolution." Thesis, 2017. http://etd.iisc.ernet.in/2005/3987.
Повний текст джерелаDesprez, Delphine. "Interactions protéiques et relation dynamique entre phosphorylation / sumoylation / ubiquitination des protéines TIF1α, β et PML: détection in vivo par BRET". Thèse, 2007. http://hdl.handle.net/1866/2785.
Повний текст джерелаThree TRIM proteins (TRIpartite Motif), TIF1α, β (Transcriptional Intermediary Factor 1) and PML (ProMyelocytic Leukaemia¬), were studied in this thesis. TIF1α is a nuclear receptor coactivator and TIF1β is the universal corepressor of the KRAB-zinc finger repressor family of which, ZNF74 is studied here as a prototypic member. PML functions as a tumor suppressor and is the essential organiser of PML-NBs (PML-Nuclear Bodies) which are very dynamic nuclear macrostructures containing more than 40 proteins. The function of these three TRIM proteins is regulated by sumoylation, a post-translational modification involving the covalent linkage of SUMO (Small Ubiquitin like MOdifier) to specific targets lysine. In this thesis, we propose to develop new methods based on BRET (Bioluminescence Resonance Energy Transfer) to detect non-covalent nuclear protein interactions but also covalent linkage to SUMO in real time in living cells. To date, BRET was never used to assess non-covalent or covalent nuclear protein interactions. Studying transcriptionally active protein interactions represents a challenge by classical methods in particular when proteins have a tendency to aggregate (TRIM family) or when characterizing nuclear matrix proteins (ZNF74). In the first article, homo- and heterodimerisation of TIF1 α and β as well as their interaction with ZNF74 was assessed by BRET using full length proteins in living mammalian cells. We ascertained the heterodimerisation of TIF1α and β. Whereas ZNF74 interacts strongly with TIF1β, no interaction was detected with TIF1α. However, we unravelled the existence of ternary complexes involving ZNF74, TIF1α and TIF1β. This suggested that a mechanisms for cross-talk between nuclear receptors and KRAB-zinc finger proteins. Thus, we showed that BRET can be advantageously used as a non-transcription-based interaction system for studying transcriptionally active proteins, including nuclear matrix proteins, in living cells. Previous studies have shown that the sumoylation of PML (a tumour suppressor) is involved in its proteasome degradation that is As2O3-inducible and dependent on the polySUMO E3 ubiquitin ligase, RNF4. In the second article, we describe the development of a new application of the BRET method for the detection of covalent and non-covalent interactions with SUMO. Owing to this SUMO BRET assay, we established that the As2O3 / RNF4-mediated degradation of PML, not only depends on PML sumoylation as previously demonstrated, but also on the integrity of its SUMO binding domain. We also demonstrated that As2O3 which increases PML sumoylation, also enhances PML / RNF4 interaction. Our study revealed that most PML SBD non covalent interactions with sumoylated proteins required the phosphorylation of serines within PML SBD that were previously described as target sites for CK2 kinase and involved in PML degradation. Despites the involvement of PML SBD in RNF4-mediated degradation, these serines which function as an SBD phospho-switch, were not required for RNF4-mediated degradation. This suggested that CK2- and RNF4-mediated PML degradation represents two distinct pathways triggering PML ubiquitin / proteasome-dependent degradation. At last, our study led to the hypothesis that the recruitment of sumoylated PML at PML-Nuclear Bodies subnuclear structures via the PML SBD and / or possibly an E3 ubiquitin ligase activity other than RNF4 (PML itself being candidate) may favour PML degradation. Our study also stresses the dynamic involvement of three PML post-translational modifications, phosphorylation, sumoylation and ubiquitination in its degradation. A third article addressing the role of TIF1β sumoylation is presented in the Appendix. We characterized the 6 SUMO targets lysine of TIF1β and demonstrated that sumoylation is required for TIF1β transcriptional repressive activity. This is in part explained by the fact that TIF1β sumoylation is a pre-requisite for histone deacetylases recruitment since TIF1β repressive activity is partly dependent on histone deacetylases. We found that TIF1β sumoylation does not influence its homodimerisation or interaction with the KRAB box of KRAB zinc finger proteins recruiting TIF1β to promoters. TIF1β sumoylation is however relying on the integrity of TIF1β PHD finger and on its self-oligomerisation. Interestingly, we demonstrated that TIF1β sumoylation is positively regulated by its interaction with KRAB domain. It is thus suggested that KRAB-zinc finger proteins recruit TIF1β at DNA promoters where they trigger increase of TIF1β sumoylation and thus enhance its repressive activity.