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Статті в журналах з теми "San Diego Convention Center"

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Автор: Grafiati

Опубліковано: 27 липня 2024

Оновлено: 28 липня 2024

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1

Akins, Meridith. "June 26-30, 2004 San Diego Convention Center San Diego, California." Journal of the American Society of Echocardiography 17, no. 9 (September 2004): A16—A17. http://dx.doi.org/10.1016/j.echo.2004.07.003.

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2

Cowan, Michael. "Boundary as Center: Inventing an American Studies Culture." Prospects 12 (October 1987): 1–20. http://dx.doi.org/10.1017/s0361233300005512.

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When the American Studies Association chose “Boundaries of American Culture” as the theme and San Diego as the site of its 1985 biennial convention, it made a particularly appropriate match between theme and site. Seen from my hotel balcony in a hazy autumnal glow, San Diego appeared a boundary city in at least three senses of relevance to the Association's work. First, lying at the border of the United States and Mexico, it hinted at the rich possibilities available to an American Studies willing to reach imaginatively beyond national boundaries, both north and south, toward a genuinely pan-American studies. Second, as a three-block walk to the beach from the convention hotel amply confirmed, San Diego borders what several commentators have called “the Mediterranean of the future”–a major arena of the globe too long and too much neglected by most Americans and Americanists. It was stimulating to welcome to the convention distinguished visitors from a dozen Asian and South Pacific countries, and more than a few speakers expressed the hope that such interaction would significantly further the comparativist and internationalist perspectives that they believed increasingly incumbent upon a nonparochial American Studies. Certainly the heartening presence in San Diego of both long-time and new colleagues from Europe, Canada, Latin America, Asia, and the South Pacific reflected a slowly but steadily growing impulse in the Association, a concrete dramatization of the premise that ideas and values, not to mention trade and power, do not stop at a nation's borders, although they may be often slowed down or even transformed at those borders.

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3

Wittgrove, Alan C. "21st Annual Meeting American Society for Bariatric Surgery San Diego Convention Center, San Diego, CA, USA, June 13-18, 2004." Obesity Surgery 13, no. 6 (December 1, 2003): 816–17. http://dx.doi.org/10.1381/096089203322618579.

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4

Souza-Smith, Flavia M., Charles H. Lang, Laura E. Nagy, Shannon M. Bailey, Loren H. Parsons, and Gary J. Murray. "Physiological processes underlying organ injury in alcohol abuse." American Journal of Physiology-Endocrinology and Metabolism 311, no. 3 (September 1, 2016): E605—E619. http://dx.doi.org/10.1152/ajpendo.00270.2016.

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This review summarizes the American Physiological Society (APS) Presidential Symposium 1 entitled “Physiological Processes Underlying Organ Injury in Alcohol Abuse” at the 2016 Experimental Biology meeting. The symposium was organized by Dr. Patricia Molina, past president of the APS, was held on April 3 at the Convention Center in San Diego, CA, and was funded by the National Institute on Alcohol Abuse and Alcoholism. The “Physiological Processes Underlying Organ Injury in Alcohol Abuse Symposium” assembled experts and leaders in the field and served as a platform to discuss and share knowledge on the latest developments and scientific advances on the mechanisms underlying organ injury in alcohol abuse. This symposium provided unique, interdisciplinary alcohol research, including several organs, liver, muscle, adipose, and brain, affected by excessive alcohol use.

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5

Courey, Mark. "Management of Unilateral Vocal Fold Paralysis/Paresis: A Laryngologist's Perspective." Perspectives on Voice and Voice Disorders 22, no. 3 (November 2012): 121–30. http://dx.doi.org/10.1044/vvd22.3.121.

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This manuscript is a follow up to a panel presentation on “Vocal Fold Paresis & Paralysis: Controversies in Evaluation & Management,” which was held during the 2011 American Speech-Language-Hearing Association (ASHA) Convention in San Diego, California. In addition to me, the other members of the panel included Sarah L. Schneider, MS, CCC-SLP, Director, Speech-Language Pathology Service, UCSF Voice and Swallowing Center; Nelson Roy, PhD, Professor, Speech & Language Pathology, Department of Communication Sciences & Disorders, University of Utah; and Marshall Smith, MD, Professor of Otolaryngology, Department of Surgery, University of Utah. During the panel, I was tasked with presenting the reasons for controversies in the diagnosis and management of vocal fold paralysis. In this manuscript, I will summarize my portion of that presentation and will provide additional information on management options for unilateral vocal fold paralysis (UVFP) from the perspective of a laryngologist.

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6

Perkins, G. A., C. W. Renken, S. J. Young, S. Lindsey, M. H. Ellisman, and T. G. Frey. "Use of High-Performance Computing Algorithms in Combination With Parallel Computing for Tomography." Microscopy and Microanalysis 3, S2 (August 1997): 1123–24. http://dx.doi.org/10.1017/s1431927600012502.

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The electron microscope is essential for resolving complex biological structures, such as mitochondria, which are too small to be viewed in detail with the light microscope. In contrast to a conventional instrument, the High-Voltage Electron Microscope (HVEM) located at the National Center for Microscopy and Imaging Research (NCMIR) can obtain images from relatively thick specimens that contain substantial three-dimensional structure. Though a single image acquired with the HVEM represents a projection through the specimen, tomographic methods can be applied to a set of images acquired from different orientations to derive a three-dimensional representation of its biological structure. Tomography requires extensive computation and considerable processing time on conventional workstations in order to reconstruct the typically large HVEM volumes from the tilt series.In order to expedite tomographic processing, we have implemented both the commonly used singleaxis tilt, R-weighted backprojection algorithm and two iterative reconstruction methods, algebraic reconstruction (ART) and simultaneous iterative reconstruction (SIRT) on the massively parallel Intel Paragon at the San Diego Supercompter Center.

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7

Gupta, Rajesh K., and Yan Liu. "KDD 2020 Highlights." ACM SIGKDD Explorations Newsletter 22, no. 2 (January 17, 2021): 1. http://dx.doi.org/10.1145/3447556.3447558.

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KDD made history in 2020. It was planned to be held in the San Diego Convention Center in an environment that would attract a large number of participants, companies to an attractive location. The program planners also made a concerted effort to broaden the intellectual scope of the forum as well as participation by diverse communities. In particular, the conference planned for offering complimentary full-time daycare to enable participation by women and parents with young children. The emergence of COVID-19 disease in March, however, caused considerable uncertainty leading to a final determination for a first-ever entirely virtual conference. This shift was dramatic at multiple levels since KDD is more than a meeting of presenters and their audience. It is also a place for demonstrations, chance encounters and a very engaging floor exhibition with its own ongoing events. Without exhibitors, their sponsors, and missing attendees, KDD won't be KDD. And it will also have a significant financial liability to the conference for the event contracts already in place. With significant cooperation from ACM and support from SIGKDD Executive Committee the team not only avoided financial impact but emerged with a net positive financial outcome even after reducing the registration fees by over 80%.

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8

Witt, J. Dale, Stuart L. Warren, Thomas G. Ranney, and James R. Baker. "Biorational and Conventional Plant Protectants Reduce Feeding by Adult Japanese Beetles." Journal of Environmental Horticulture 17, no. 4 (December 1, 1999): 203–6. http://dx.doi.org/10.24266/0738-2898-17.4.203.

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Abstract Nine commercial plant protectants were tested for efficacy against feeding by adult Japanese beetles (Popillia japonica Newman). Treatments included an endotoxin from a bacterium [Bacillus thuringiensis (Berl.) var. san diego]; microencapsulated pyrethrum extracted from pyrethrum [Tanacetum cinnerariifolium (Trev.) Schultz-Bip.], two extracts from neem (Azadirachta indica A. Juss); an extract from cayenne pepper (Capsicum annuum L. var. annuum Longum Group); an extract from garlic (Allium sativum L.); rotenone extracted from galedupa (Derris trifoliata Lour.) and barbasco [Lonchocarpus sericeus (Poiret) Kunth] or timbo (L. nicou Aublet D.C.); carbaryl (1-napthyl methylcarbamate); and the pyrethroid, fenpropathrin. Experimental plots were located at the Horticulture Field Laboratory (HFL), Raleigh, and the Mountain Horticultural Crops Research and Extension Center (MHCREC), Fletcher, NC. Himalayan birches [Betula utilis var. jacquemontii (Spach) Winkl.] were used as host plants. Treatments were applied twice, 2 weeks apart. Five weeks after initial application, trees treated with fenpropathrin averaged 2% defoliation vs. 40% defoliation for the control trees at HFL; and 3% defoliation vs. 100% defoliation for the control trees at MHCREC. Rotenone treatments averaged 10% defoliation at HFL and 92% defoliation at MHCREC. The following treatments were not significantly different from the control at week 5 at either location: garlic extract, neem extracts, cayenne pepper extract, microencapsulated pyrethrum, encapsulated bacterial endotoxin, and carbaryl.

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9

Noble, Charissa. "‘Extended’ vocal techniques in the institution: The Extended Vocal Techniques Ensemble at the Center for Musical Experiment at UCSD." Journal of Interdisciplinary Voice Studies 7, no. 2 (December 1, 2022): 137–62. http://dx.doi.org/10.1386/jivs_00062_1.

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In the decades following the Second World War, novel sound technologies and the proliferation of ethnomusicological field recordings ignited curiosity and experimentation among many musicians; these cultural phenomena also sparked a re-examination of conventional Euro-American musical sound sources. Classically trained instrumentalists and singers – particularly those associated with the ‘experimental tradition’ – cultivated intentionally idiosyncratic musical practices and widened their range of sonic possibility; this cultural zeitgeist included a heightened interest in so-called extended vocal techniques. In this article, I examine the research and creative output of the Extended Vocal Techniques Ensemble (EVTE) of the University of California at San Diego (UCSD). Drawing from published literature, interviews and archival sources to write this account of the EVTE’s multifaceted work, I contextualize the group’s activities within UCSD’s interdisciplinary emphasis as well as in the broader social–historical discourses of ‘extended vocal techniques’. Furthermore, I address the implications of their story within the broader politics of vocal aesthetics and pedagogy in Euro-American classical music contexts. By unearthing the EVTE’s interdisciplinary vision for vocal study, I hope to not only spark interest in this ensemble’s contributions, but also to revive (and build upon) their vision of a radically reimagined vocal artistry and study in academic music and beyond.

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10

Dwaipayan Samaddar, Md. Rijwan Alam, and Jaya Bagchi Samaddar. "Negative pressure wound therapy and conventional wound management at a rural tertiary care center – A comparative study." Asian Journal of Medical Sciences 14, no. 5 (May 1, 2023): 218–24. http://dx.doi.org/10.3126/ajms.v14i5.51791.

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Background: Wounds are a major source of morbidity and sometimes, mortality and there are several ways to treat them. Negative pressure wound therapy (NPWT) is one way, and this involves the use of a suction device to aspirate and remove fluids, debris, and infectious materials from the wound bed to promote the formation of granulation tissue and wound healing. Another way is with the use of conventional wound dressings. Aims and Objectives: The aim was to compare NPWT and conventional wound dressings for the poor in a rural setting. Materials and Methods: Sixty consecutive cases clinically presenting with wounds between March 2018 and August 2019 were examined and divided into NPWT or conventional wound dressing groups. Outcome was measured by recording wound scores on day 7 or thereafter. Cases and controls were studied from admission until complete healing. Outcome and complications of NPWT and conventional wound dressings were noted. Results were tabulated in MS excel and evaluated using Graphpad Prism 9 software (San Diego, CA, USA). Results: Many patients (33.33%) were in the 5th and 6th decades of life and most (77%) were male. Many wounds were located on the foot (40%). Those patients younger than 40 years of age with a wound <10 days old had a better median wound score in both the groups. The majority of wounds (43.33%) were traumatic. Wound healing was better in non-diabetics and non-smokers. There was a considerable reduction in the organism load in the NPWT group (P=0.0078). Complications were minor. The NPWT group had a significantly shorter mean hospital stay (P=0.0001). Conclusion: NPWT enhanced granulation tissue formation leading to earlier wound healing and faster recovery compared to conventional wound dressings.

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11

Uffen, Ellen. "San Diego: ASHA’s 2005 Convention." ASHA Leader 10, no. 8 (June 2005): 6–33. http://dx.doi.org/10.1044/leader.acc.10082005.6.

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12

Ueno, Toshiaki, Brandon R. Macias, William T. Yost, and Alan R. Hargens. "Noninvasive assessment of intracranial pressure waveforms by using pulsed phase lock loop technology." Journal of Neurosurgery 103, no. 2 (August 2005): 361–67. http://dx.doi.org/10.3171/jns.2005.103.2.0361.

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✓ Elevated intracranial pressure (ICP) is a major factor associated with incidences of morbidity and mortality in patients with neurological disorders. The use of conventional methods for ICP monitoring is currently limited to patients with severe neurological conditions because of the methods' invasive nature. The authors have developed an ultrasonic device capable of monitoring ICP waveforms noninvasively by using a pulsed phase lock loop (PPLL) technique. The PPLL device records skull movement (several meters) associated with ICP pulsations. The purpose of this study was to correlate PPLL waveforms with invasively measured ICP waveforms in patients at the University of California San Diego Medical Center (13 patients). A linear regression analysis revealed a high correlation between PPLL waveforms and invasively measured ICP waveforms during the same time domain (r2 = 0.88). A coherence function analysis, which provides the fractional portion of the mean square value at the output that is contributed by the input at a certain frequency, showed medium to high correlations (r2 = 0.50–0.90) between PPLL waveforms and invasively measured ICP waveforms at each harmonic wave components. Furthermore, there was a significant correlation (r2 = 0.680, p < 0.01) in the harmonic distortion ratio (an index representing how much a given waveform is distorted from a pure sine wave) between PPLL waveforms and invasively measured ICP waveforms. In conclusion, PPLL technology enables the noninvasive evaluation of ICP dynamics in clinical settings.

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13

Sandip Kumar Sengupta, Rupsha Dutta Pal, Dwaipayan Samaddar, Jaya Bagchi Samaddar, and Bidyut Krishna Goswami. "Comparative analysis of different cervical screening methods with special reference to the WHO recommended human papillomavirus detection at a rural tertiary care center - A pilot study." Asian Journal of Medical Sciences 15, no. 2 (February 1, 2024): 178–83. http://dx.doi.org/10.3126/ajms.v15i2.60320.

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Background: Cervical cancer (Ca Cx) the 4th common cancer has a high mortality rate. Human Papilloma Virus (HPV) is chiefly responsible for a long latent period to progress from preinvasive to invasive Ca Cx. So it can be prevented by screening procedures such as visual inspection with acetic acid (VIA), conventional cervical PAP smear (CP), liquid-based cytology (LBC), and high-risk (HPV-hr) detection along with vaccination. Aims and Objectives: The study aims to determine the socio-demographic profile of Ca Cx and the most appropriate cost-effective community screening method. Materials and Methods: A prospective observational study with 80 symptomatic women of reproductive and peri/postmenopausal age groups attending the Gynecology Department who underwent VIA, CP, and LBC and thereby detected positive along with screened negative but clinically suspicious women were tested for HPV-hr detection. Results were tabulated into an Excel sheet and screening methods were compared using Chi-square test, gold standard being cervical histopathology (P<0.5 significant). Statistical software used - Graphpad Prism 9 (San Diego, CA). Results: The mean age was 43.3 years. Multiparity and early marriage were seen in 80% and 45% respectively. Inflammatory lesions were best diagnosed by CP but epithelial cell abnormality and more satisfactory smears by LBC (P<0.05). Sensitivity was highest (93.75%) in VIA, positive predictive value, and specificity in CP (91.66%, 75%). negative predictive value was highest in VIA and HPV-hr DNA (50%). Conclusion: VIA with CP/LBC is an economically viable and effective screening method for Ca Cx in developing countries along with HPV vaccination.

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14

Siddiqui, Dilnawaz. "The 20th Annual Conference of the AMSS." American Journal of Islam and Society 9, no. 1 (April 1, 1992): 126–31. http://dx.doi.org/10.35632/ajis.v9i1.2598.

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The third decade of the Association of Muslim Social Scientists' (AMSS)existence witnessed the collective effort by some of its members to identify majorareas for inclusion in its research agenda. Besides taking stock of past performance,the main determinants included those recent events in the ummah whichhave affected it as a whole and the ensuing problems calling for immediateattention.Following established tradition, the AMSS and one of its sister professionalorganizations, the Association of Muslim Scientists and Engineers (AMSE),convened their conferences at the same time and place.This year's banquet speaker was H.R.H. Crown Prince Hasan bin Talalof Jordan, whose address was delivered in his absence by Mohammad A.Hamadan, former Minister of Education of Jordan. The main thrust of PrinceHasan's address was the need for cooperation among the ummah's varioussegments in the service of professional and human resource development. TheIsma'il and Lamya al Fariiqi Memorial Lecture was given by Zafar I. Ansari,Director General, Islamic Research Center, Islamabad, Pakistan. The AMSEkeynote speaker was Ali Nayfeh, Virginia Polytechnic Institute and State University,Blacksburg, VA. Nayfeh suggested practical ways of fostering scientificand technological advancement in the ummah through intra-ummah as well asinternational collaboration.The main program consisted of seventeen thematic panels organized intoeleven sessions. The opening session was chaired by Sayyid M. Syeed, GeneralSecretary of the AMSS. It consisted of the welcome speeches of S. ImtiazAhmad, Conference Chair and President of the Islamic Society of NorthAmerica (ISNA); Sulayman Nyang, President of the AMSS; and MohammadZohdy, President of the AMSE. The Convention Chair also read out the felicitousmessages received from the White House, the State House, and the localgovernment. The program preview was given by its co-chairs, Mumtaz Ahmadand Dilnawaz Siddiqui (AMSS), and Sayed A. Nassar (AMSE).The second session had two concurrent panels: 1) "History of Muslim Communitiesin North America;' organized and moderated by Salahuddin Malik,State University of New York (SUNY ) at Brockport, Brockport, NY, and 2)'J\ndragogy: Education of Adults;' which was chaired by Mushtaqur Rahman,University oflowa at Ames, Ames, IA. The history panel featured Anwar Dil,U.S. International University, San Diego, CA, who traced the history of Muslim ...

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15

Taylor, P. "The San Diego Supercomputer Center." IEEE Computational Science and Engineering 1, no. 3 (1994): 10. http://dx.doi.org/10.1109/mcse.1994.313161.

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16

Rodriguez, Renato. "San Diego History Center Research Archive." California History 96, no. 1 (2019): 125–29. http://dx.doi.org/10.1525/ch.2019.96.1.125.

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17

Maisel, Merry. "Science At the San Diego Supercomputer Center." International Journal of Supercomputing Applications 1, no. 2 (June 1987): 6–10. http://dx.doi.org/10.1177/109434208700100202.

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18

Tapson, Victor F., William Auger, Peter Fedullo, Eckhard Mayer, and Christopher McGregor. "Surgically Curable Pulmonary Hypertension: A View From the Experts." Advances in Pulmonary Hypertension 2, no. 1 (January 1, 2003): 21–25. http://dx.doi.org/10.21693/1933-088x-2.1.21.

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Five physicians addressed important issues in the diagnosis and management of patients with pulmonary thromboembolic disease. The roundtable discussion was moderated by Victor F. Tapson, MD, Associate Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, and included William Auger, MD, Professor of Clinical Medicine, University of California, San Diego, Medical Center, San Diego, California; Peter Fedullo, MD, Clinical Professor of Medicine, University of California, San Diego, Medical Center; Eckhard Mayer, MD, Professor of Thoracic Surgery, Department of Cardio-Thoracic Surgery, University Hospital, Mainz, Germany; and Christopher McGregor, MD, Professor of Surgery, Consultant in Cardio-Thoracic Surgery, and Director of the Mayo Clinic William J von Liebig Transplant Center, Rochester, Minnesota.

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19

Baird, Samuel G., Jason P. Caffrey, James D. Bomar, Christine L. Farnsworth, Justin R. Ryan, Parham Gholami, and Vidyadhar V. Upasani. "Comparison of Acetabular Morphology Changes After Pediatric Pelvic Osteotomies Using Patient-Specific 3-D Models." Journal of the Pediatric Orthopaedic Society of North America 4, no. 3 (August 1, 2022): 1–10. http://dx.doi.org/10.55275/jposna-2022-0079.

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Background: Surgical management to improve hip joint morphology in immature patients with acetabular dysplasia includes Pemberton, Dega, San Diego, and Salter acetabular osteotomies. This study evaluates acetabular morphology between these osteotomies using patient-specific 3-D printing technology. Methods: Preoperative computed tomography scans (CTs) from patients with acetabular dysplasia were rendered into 3-D printable formats. Quadruplicate pelvis models for each patient received Pemberton, Dega, San Diego, and Salter osteotomies. CTs were obtained of each model before and after osteotomy. Acetabular volume and regional coverage angles were computed and compared before and after each osteotomy. Results: Fourteen hips (14 patients) were included; 1 male, 13 female; age 5.4±1.3 years (3.9-7.5 years). Acetabular volume decreased following each osteotomy (Pemberton by 14%, Dega by 19%, San Diego by 19%, and Salter by 6%), with smaller volume reduction for Salter than the others (p<0.05). Volume change was similar between Pemberton, Dega, and San Diego (p=0.32). Pemberton increased coverage in Superior and Anterior regions, Dega increased coverage in Superior, Superior-Anterior, and Anterior regions, San Diego increased coverage in Posterior, Superior-Posterior, and Superior regions, and Salter increased coverage in Superior region (p<0.05). Conclusions: Acetabular volume changes found in this study support the convention that redirectional osteotomies such as Salter are more volume neutral than incomplete osteotomies such as Pemberton, Dega, and San Diego. However, even the Salter decreased acetabular volume. This study re-demonstrated that each osteotomy studied changes acetabular coverage in different regions. Based on this, a surgeon’s osteotomy decision should be based on the dysplastic acetabulum morphology.

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Channick, Richard, Hap Farber, Nicholas Hill, and Robert Schilz. "Pulmonary Hypertension Roundtable." Advances in Pulmonary Hypertension 4, no. 2 (May 1, 2005): 24–29. http://dx.doi.org/10.21693/1933-088x-4.2.24.

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This discussion was moderated by Richard Channick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California. The physicians participating included Hap Farber, MD, Director, Pulmonary Hypertension Center, Boston University Medical Center, Boston, Massachusetts; Nicholas Hill, MD, Chief, Pulmonary, Critical Care and Sleep Division, Tufts-New England Medical Center, Boston, Massachusetts; and Robert Schilz, PhD, DO, Director of Lung Transplantation and Advanced Lung Disease, and Assistant Professor of Medicine, Case Western Reserve University, Cleveland, Ohio.

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21

Herold, Christopher D., Robert L. Fitzgerald, David A. Herold, and Taiwei Lu. "Neural Network." Laboratory Automation News 1, no. 3 (July 1996): 16–17. http://dx.doi.org/10.1177/221106829600100304.

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A hybrid neural network (HNN) developed by Physical Optics Corporation (Torrance, CA) is helping a team of scientists with the San Diego Veterans Administration Medical Center and University of California, San Diego Pathology Department automate the detection and identification of Tuberculosis and other mycobacterial infections.

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22

&NA;. "National Nursing Staff Development Organization Convention in San Diego in 2010." Journal for Nurses in Staff Development (JNSD) 26, no. 2 (March 2010): 90–92. http://dx.doi.org/10.1097/nnd.0b013e3181d46f5a.

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23

McLaughlin, Vallerie V., Richard N. Channick, Ivan M. Robbins, and Victor F. Tapson. "Pulmonary Hypertension Roundtable: Recapping 5 Years, Exploring Emerging Approaches." Advances in Pulmonary Hypertension 5, no. 4 (December 1, 2006): 32–39. http://dx.doi.org/10.21693/1933-088x-5.4.32.

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This discussion was moderated by Vallerie V. McLaughlin, MD, Associate Professor of Medicine and Director, Pulmonary Hypertension Program, University of Michigan Health System, Ann Arbor, Michigan. Panel members included Richard N. Channick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California; Ivan M. Robbins, MD, Director of the Pulmonary Hypertension Center, Vanderbilt University, Nashville, Tennessee; and Victor F. Tapson, MD, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina.

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24

Payne, James R., Eric Terrill, Melissa Carter, Mark Otero, William Middleton, Andy Chen, Walter Nordhausen, et al. "FIELD MEASUREMENTS OF FLUORESCEIN DYE DISPERSION TO INFORM DISPERSED-OIL PLUME SAMPLING AND PROVIDE INPUT FOR OIL-TRANSPORT MODELING1." International Oil Spill Conference Proceedings 2008, no. 1 (May 1, 2008): 515–25. http://dx.doi.org/10.7901/2169-3358-2008-1-515.

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ABSTRACT The California Department of Fish and Game Office of Spill Prevention and Response (CA OSPR) is utilizing oil-spill fate and transport modeling to develop the time and spatial scales, and equipment needs, for a formal Dispersed Oil Monitoring Plan (DOMP). When fully implemented, the DOMP will aid in documenting hydrocarbon concentrations in the water column, potentially exposed organisms (zooplankton), and the impacts of entrained oil and dissolved hydrocarbons with and without dispersant applications. Fluorescein dye studies off San Diego, California (USA) have been completed to test the operational framework for repeated sampling of dispersed oil plumes as outlined in the DOMP, to allow evaluation of high-frequency radar (HP-Radar) for providing surface current input data to oil spill models, and to provide verification of model-predicted movement of subsurface oil (dye) by comparison with drogue movement and measured dye concentrations over three dimensions and time. Aerial photodocumentation, subsurface drogues, dye transport, and HF-Radar were used to measure near-surface current fields at varying depths. High-resolution subsurface dye-plume structure was mapped using an in situ GPS-coupled towed fluorometer equipped with pressure sensors to provide dye concentration data as a function of time, position, and depth. In addition, data from the more traditional Special Monitoring of Applied Response Technology (SMART) protocols utilized by the U.S. Coast Guard (USCG) were compared with the in situ towed-fluorometer measurements, and conventional CTD data were collected to determine the mixed layer depth, an important variable in monitoring dispersion of oil in the water column. As a result of these efforts, significant progress has been made on developing and testing sampling protocols for the DOMP, and nearly continuous and synoptic data have been obtained from seven cruises conducted over a 12-month period. These data sets (available on-line through the Coastal Response Research Center (CRRC) website: http://www.crrc.unh.edu/) are being analyzed and integrated to support oil spill model development and verification with direct applicability to spill response decision making, net environmental benefit analysis, natural resource damage assessments, and educating the spill community and public.

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Chung, Chih-Hung, and Muh-Hwa Yang. "Abstract 1388: Spatial transcriptome analysis of EMT trait and corresponding immune composition study in HNSCC." Cancer Research 84, no. 6_Supplement (March 22, 2024): 1388. http://dx.doi.org/10.1158/1538-7445.am2024-1388.

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Abstract Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant cancer worldwide. Conventional treatments for this type of cancer involve surgical resection, radiation therapy, and chemotherapy. However, in cases where the tumor recurs or metastasizes distantly, rendering surgical resection or radiation therapy impractical, the only viable option is the utilization of targeted drugs in conjunction with chemotherapy. Despite such interventions, the prognosis remains grim. Hence, the identification of genetic characteristics or biomarkers associated with easy metastasis or recurrence in the early stages of the tumor has become imperative for effective head and neck cancer treatment. The objective of this study is to analyze tumor specimens from the primary site and lymph node metastasis post-surgical resection in HNSCC patients. We employed the GeoMx Digital Spatial Profiler (DSP) for imaging-based digitized gene expression analysis. The DSP provides gene expression information at specific locations we selected, such as the primary tumor center core, primary tumor invasion borders, and lymph node metastasis specimens. The GeoMx DSP spatial analysis tool illustrates the cancer transcriptome atlas (CTA), encompassing the expression of 1825 genes related to cancer and immunity from the primary site to the metastatic site. We identified tissue-specific EMT gene expression patterns in paired tumor regions of interest (ROIs). ITGB1 emerged as the most significant co-expression marker in the primary outer tumor and metastatic tumor. Distinct EMT signature genes expressed in the HNSCC primary site and lymph node metastatic site were also discovered. Additionally, we conducted CTA profiling in correlated stroma ROIs. Through myeloid activity analysis in HNSCC paired samples, we identified distinct myeloid activation signatures in primary and metastatic site stroma cells. These results will provide crucial insights into head and neck cancer treatment strategies based on different tumor site characteristics. Citation Format: Chih-Hung Chung, Muh-Hwa Yang. Spatial transcriptome analysis of EMT trait and corresponding immune composition study in HNSCC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1388.

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26

&NA;. "SAN ANTONIO CONVENTION CENTER & THE PLAZA HOTEL SAN ANTONIO, TEXAS." Clinical Nuclear Medicine 20, no. 1 (January 1995): 87. http://dx.doi.org/10.1097/00003072-199501000-00030.

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27

Channick, Richard, Kenneth R. McCurry, Ronald Pearl, and Stuart Rich. "Meeting the Challenge of Surgery and Pulmonary Hypertension: How to Manage the “Hemodynamic Environment” to Optimize Outcomes." Advances in Pulmonary Hypertension 6, no. 2 (April 1, 2007): 92–95. http://dx.doi.org/10.21693/1933-088x-6.2.92.

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This discussion was moderated by Richard Chan-nick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California. Panel members included Kenneth R. McCurry, MD, Assistant Professor of Surgery, Division of Cardiothoracic Surgery, Director, Lung and Heart-Lung Transplantation Programs, University of Pittsburgh Department of Surgery, Pittsburgh, Pennsylvania; Ronald Pearl, MD, PhD, Professor and Chair, Anesthesia Department, Stanford University School of Medicine, Stanford, California; and Stuart Rich, MD, Professor of Medicine, Section of Cardiology, Center for Pulmonary Hypertension, University of Chicago, Chicago, Illinois.

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28

Feder, Toni. "San Diego Center Theorizes About the Physics of Biology." Physics Today 56, no. 1 (January 2003): 23. http://dx.doi.org/10.1063/1.1554131.

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Brooker, Jewel Spears. "A Conversation with Denise Levertov." Christianity & Literature 45, no. 2 (March 1996): 217–24. http://dx.doi.org/10.1177/014833319604500205.

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The Conference on Christianity and Literature sponsored a reading by Denise Levertov at the 1994 Annual Convention of the Modern Language Association in San Diego. In addition, CCL presented the poet with a Lifetime Achievement Award, and president Jewel Spears Brooker interviewed her for Christianity and Literature. The interview, which had to be conducted by mail, was completed in November 1995.

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McLaughlin, Vallerie V., Richard N. Channick, Ivan M. Robbins, and Victor F. Tapson. "Pulmonary Hypertension Roundtable." Advances in Pulmonary Hypertension 4, no. 3 (August 1, 2005): 26–30. http://dx.doi.org/10.21693/1933-088x-4.3.26.

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In this discussion four experts shared insights on what might be considered the “gestalt” of diagnosing and monitoring pulmonary arterial hypertension. They ranged over a broad spectrum of issues that included thromboembolic pulmonary hypertension, exercise testing, hemodynamics, imaging studies, and response to therapy. The discussion was moderated by Vallerie V. McLaughlin, MD, Associate Professor of Medicine, Director, Pulmonary Hypertension Program, University of Michigan Health System, Ann Arbor, Michigan. The participants included Richard N. Channick, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California; Ivan M. Robbins, MD, Director, Pulmonary Hypertension Center, Vanderbilt University, Nashville, Tennessee; and Victor F. Tapson, MD, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina.

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31

SoRelle, Ruth. "San Diego Family Justice Center Coordinates Services for Abuse Victims." Emergency Medicine News 25, no. 12 (December 2003): 33. http://dx.doi.org/10.1097/00132981-200312000-00023.

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32

McGoon, Michael, Victor F. Tapson, Richard N. Channick, Valerie V. McLaughlin, Ronald J. Oudiz, and Ivan M. Robbins. "Recapping Highlights from Pulmonary Hypertension Association Scientific Sessions and Identifying Key Issues Driving Translational Research." Advances in Pulmonary Hypertension 3, no. 3 (August 1, 2004): 23–27. http://dx.doi.org/10.21693/1933-088x-3.3.23.

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This discussion was moderated by Michael McGoon, MD, Professor of Medicine and Consultant in the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota. Participants included members of the Editorial Advisory Board of Advances in Pulmonary Hypertension: Victor F. Tapson, MD, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, and Editor-in-Chief of the journal; Richard N. Channick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California; Vallerie V. McLaughlin, MD, Associate Professor of Medicine, Director, Pulmonary Hypertension Program, University of Michigan Health System, Ann Arbor, Michigan; Ronald J. Oudiz, MD, Associate Professor of Medicine, UCLA School of Medicine, and Director, Liu Center for Pulmonary Hypertension, Division of Cardiology, Harbor-UCLA Medical Center, Torrance, California; and Ivan M. Robbins, MD, Director, Pulmonary Hypertension Center, Vanderbilt University, Nashville, Tennessee.

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33

Smith, MacKenzie, and Reagan Moore. "Digital Archive Policies and Trusted Digital Repositories." International Journal of Digital Curation 2, no. 1 (December 2, 2008): 92–101. http://dx.doi.org/10.2218/ijdc.v2i1.16.

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The MIT Libraries, the San Diego Supercomputer Center, and the University of California San Diego Libraries are conducting the PLEDGE Project to determine the set of policies that affect operational digital preservation archives and to develop standardized means of recording and enforcing them using rules engines. This has the potential to allow for automated assessment of “trustworthiness” of digital preservation archives. We are also evaluating the completeness of other efforts to define policies for digital preservation such as the RLG/NARA Trusted Digital Repository checklist and the PREMIS metadata schema. We present our results to date.

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34

Taps, Jennifer. "RTI Services for Children With Mild Articulation Needs: Four Years of Data." Perspectives on School-Based Issues 9, no. 3 (October 2008): 104–10. http://dx.doi.org/10.1044/sbi9.3.104.

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Abstract This article summarizes 4 years of data from San Diego Unified School District's Speech Improvement Class model for students with mild articulation needs. The district made a gradual shift from special education to general education. Data demonstrate that most students complete the class in 17-20 treatment hours. Three factors have been fundamental to the success of this program: the Articulation Resource Center, ongoing professional development, and a well-defined set of procedures. Challenges and concerns are also discussed. Overall, speech-language pathologists in San Diego Unified are implementing this class effectively and have branched out into other response to intervention supports.

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35

Fondad, Kenneth D., Dwight Correia, and Jack Swerlein. "STARTUP EXPERIENCE OF THE SAN DIEGO METRO BIOSOLIDS CENTER DEWATERING PROCESS." Proceedings of the Water Environment Federation 2000, no. 1 (January 1, 2000): 531–50. http://dx.doi.org/10.2175/193864700785377663.

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36

Parker, Barbara A., Maria Clemence Schwaederle, Richard B. Schwab, Gregory A. Daniels, David Eric Piccioni, Teresa L. Helsten, Lyudmila Bazhenova, Paul T. Fanta, Scott Michael Lippman, and Razelle Kurzrock. "Precision oncology: the UC San Diego Moores Cancer Center PREDICT experience." Journal of Clinical Oncology 33, no. 15_suppl (May 20, 2015): 11103. http://dx.doi.org/10.1200/jco.2015.33.15_suppl.11103.

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37

Schwaederle, Maria, Barbara A. Parker, Richard B. Schwab, Gregory A. Daniels, David E. Piccioni, Santosh Kesari, Teresa L. Helsten, et al. "Precision Oncology: The UC San Diego Moores Cancer Center PREDICT Experience." Molecular Cancer Therapeutics 15, no. 4 (February 12, 2016): 743–52. http://dx.doi.org/10.1158/1535-7163.mct-15-0795.

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38

Nagao, Azusa. "Clinical internship at UC San Diego Hemophilia and Thrombosis Treatment Center." Japanese Journal of Thrombosis and Hemostasis 34, no. 5 (2023): 593–95. http://dx.doi.org/10.2491/jjsth.34.593.

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39

Ellisman, Mark H., Stephen J. Young, G. Y. Fan, Guy Perkins, Steve Lamont, and Maryann E. Martone. "Highlights of Selected Microscopy Research Resource Activities at San Diego." Microscopy and Microanalysis 3, S2 (August 1997): 275–76. http://dx.doi.org/10.1017/s1431927600008266.

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The intermediate high-voltage electron microscope (IVEM) located at the National Center for Microscopy and Imaging Research at San Diego (NCMIR) can image relatively thick specimens that contain substantial three-dimensional (3-D) structure. Electron tomography is an important tool used at NCMIR for deriving 3-D cellular and subcellular structure from IVEM images. Reconstruction algorithms commonly used in electron tomography include weighted back projection, and iterative algebraic reconstruction techniques such as ART and SIRT. Improvements in reconstruction quality are possible using the iterative algorithms. Because these algorithms are computationally intensive, we have ported them to massively parallel computers at the San Diego Supercomputer Center, reducing the computation time over that required with workstation level machines.The quality of tomographic data for the 3-D reconstruction of biological structures is also being enhanced by NCMIR projects to improve the microscope. We have designed and constructed special electron optics and microscope control systems for the JEOL 4000EX.

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40

Maddela, Joanna Joyce, Maria Castaneda, Petra den Hollander, Nick Kuburich, and Sendurai Mani. "Abstract LB225: Regulation of breast cancer stem cell identity by PLK1 and FOXC2." Cancer Research 84, no. 7_Supplement (April 5, 2024): LB225. http://dx.doi.org/10.1158/1538-7445.am2024-lb225.

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Abstract One of the main drivers for the drastic reduction in survival rates caused by metastatic breast cancer is attributed to Epithelial-to-Mesenchymal Transition (EMT). During embryonic development and wound healing, EMT plays a vital role and during cancer pathogenesis, cancer cells reactivate this program to gain plasticity, migration, and invasion promoting metastasis. In addition, EMT also plays a crucial role in generating a subpopulation of highly resilient tumor cells known as cancer stem cells (CSCs). Moreover, following conventional treatment, residual tumor cells that remain after treatment tend to exhibit CSC properties. EMT-induced cancer stem cells exhibit heightened plasticity and stemness, significantly fueling the metastatic spread of cancer and enhancing the endurance and adaptability throughout the process of metastasis. Thus, understanding the molecular intricacies governing stem cell properties holds immense potential for developing targeted therapies to target metastasis and the development of resistance to treatments. To further elucidate EMT-induced cancer stem cell generation, our lab has demonstrated that the Polo-like kinase 1 (PLK1), an important G2/M regulator, plays an important role in the generation of CSCs through Forkhead box protein C2 (FOXC2). Most importantly, we have shown that the FOXC2 transcription factor, known to be crucial in embryonic development, now has emerging roles in metastatic cancer progression. FOXC2 is positioned at the center of the complex network of signal transduction pathways and functions downstream of most EMT-inducing transcription factors. FOXC2 is necessary for the acquisition and maintenance of stem cell property. In addition, we found that phosphorylation of FOXC2 by PLK1 stabilizes, and inhibition of PLK1 causes a decrease in FOXC2 and stemness in cancer cells. This led us to hypothesize that EMT-induced CSC generation is driven by the PLK1-FOXC2 axis. By expressing phosphomimetic and non-phosphorylatable FOXC2 mutants in breast cancer cell lines, we show that PLK1 phosphorylation is necessary for gaining stemness and an increase in symmetric self-renewal type of stem cell division. Evidence will be presented as to how we are targeting the PLK1-FOXC2 axis to make tumors sensitive to standard-of-care treatments. Citation Format: Joanna Joyce Maddela, Maria Castaneda, Petra den Hollander, Nick Kuburich, Sendurai Mani. Regulation of breast cancer stem cell identity by PLK1 and FOXC2 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB225.

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41

Costello, Caitlin L., Edward D. Ball, Sue Corringham, Hongying Li, and Karen Messer. "Impact of Deletion 17p On the Outcome of Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma." Blood 120, no. 21 (November 16, 2012): 3099. http://dx.doi.org/10.1182/blood.v120.21.3099.3099.

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Abstract Abstract 3099 Background: The development of a risk-stratification model that relies on molecular cytogenetic markers to assess disease aggressiveness and provide therapeutic guidance would be beneficial for the management of patients with multiple myeloma (MM). High-risk cytogenetic abnormalities, including deletion 17p (del17p), are known to confer a poor prognosis. Intensified consolidation with high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) following induction therapy has been proposed as the preferred initial treatment for high-risk MM, such as del17p. With this background, we report the impact of del17p on the timing and outcome of transplant in patients with MM. Methods: We performed a retrospective review of 226 patients with MM who underwent HDT/ASCT at the University of California, San Diego Moores Cancer Center between 1/2000 and 7/2011. Conventional cytogenetic analyses were utilized for all patients either at diagnosis or at relapse, but prior to ASCT. Fluorescence in situ hybridization was also assessed when available. The primary objective was to evaluate the impact of del17p, a known high-risk chromosomal abnormality, on the overall survival (OS) and progression-free survival (PFS) after ASCT, compared with patients without chromosomal abnormalities. A secondary objective was to assess the OS and PFS for patients with del17p who received ASCT within a year of diagnosis, compared with those who underwent ASCT more than 12 months from diagnosis. Results: In 226 patients with conventional cytogenetic data prior to ASCT, chromosomal abnormalities were noted in 82 (36%) patients. Of these, 21 (25%) patients harbored a del17p abnormality. Table 1 shows the patient characteristics and ASCT outcomes. Prior to undergoing ASCT, 4 (19%)patients with del17p achieved a complete remission (CR) or stringent complete remission (sCR), and 6 (29%) achieved a CR or sCR after ASCT. In patients without chromosomal abnormalities, 19 (13%) achieved CR or sCR prior to ASCT, and 45 (31%) achieved it after ASCT. Median follow-up of surviving patients was 47 months (range 5–283). Median PFS after ASCT in patients with del17p and normal cytogenetics were 8.3 months (95%CI: 4.6-N/A) and 33 months (95%CI: 21.7–61.8), respectively (HR 2.15, 95%CI: 1.19–3.89; p=0.011) (Figure 1). Median OS after ASCT in patients with del17p and normal cytogenetics were 47.5 months (95%CI: 19.9-N/A) and 68 months (95%CI 51.1-N/A), respectively (HR: 2.27, 95%CI 1.15–4.48; p=0.018) (Figure 2). Median PFS in patients with del17p who received an ASCT after 12 months and within 12 months from diagnosis was 6.13 months (95%CI: 2.7-NA) and 22.6 months (95%CI: 5.4-NA), respectively (HR=1.22, 95%CI 0.40–3.82; p=0.71). Median OS in del17p patients who received an ASCT after 12 months and within 12 months from diagnosis was 65.6 months (95%CI: 19.3-NA) and 47.5 months (95%CI: 19.9-NA), respectively (HR=0.97, 95%CI 0.26–3.62; p=0.96). Conclusions: In this single center study with long follow up, we demonstrate that a del17p abnormality in MM confers a shorter PFS and OS after ASCT. Furthermore, the use of HDT/ASCT as part of the upfront treatment plan within 12 months of diagnosis does not significantly affect the outcome in patients with a del17p abnormality. Further studies are required to better define a risk-stratified treatment plan for this subset of high-risk multiple myeloma. Disclosures: No relevant conflicts of interest to declare.

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42

Nguyen, Uyen-Sa D. T., Kenneth J. Rothman, Serkalem Demissie, Debra J. Jackson, Janet M. Lang, and Jeffrey L. Ecker. "Transfers Among Women Intending A Birth Center Delivery in the San Diego Birth Center Study." Journal of Midwifery & Women's Health 54, no. 2 (March 4, 2009): 104–10. http://dx.doi.org/10.1016/j.jmwh.2008.11.002.

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43

Fonda, Kenneth D., Dwight Corriea, and Jack Swerlein. "STARTUP EXPERIENCE OF THE SAN DIEGO METRO BIOSOLIDS CENTER CENTRIFUGE THICKENING PROCESS." Proceedings of the Water Environment Federation 2002, no. 3 (January 1, 2002): 261–77. http://dx.doi.org/10.2175/193864702785302780.

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44

Williams, Ebonee P. M. "Case Study #5: University of California San Diego – Gordon Engineering Leadership Center." New Directions for Student Leadership 2022, no. 173 (March 2022): 109–11. http://dx.doi.org/10.1002/yd.20491.

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45

WONG-STAAL, FLOSSIE. "Highlights from the University of California San Diego Center for AIDS Research." AIDS Research and Human Retroviruses 13, no. 2 (January 20, 1997): 117–20. http://dx.doi.org/10.1089/aid.1997.13.117.

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46

Kerwick, Kit, Nancy Hilyard, Judith Schnack, Kathryn St. Morris, Cathy Verkaaik, and Martha Wiley. "ON THE SCENE: Department of Veterans Affairs Medical Center, San Diego, California." Nursing Administration Quarterly 19, no. 3 (1995): 45–73. http://dx.doi.org/10.1097/00006216-199501930-00009.

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47

Kallen, Alexander J., Timothy J. Driscoll, Scott Thornton, Patrick E. Olson, and Mark R. Wallace. "Increase in Community-Acquired Methicillin-Resistant Staphylococcus aureus at a Naval Medical Center." Infection Control & Hospital Epidemiology 21, no. 3 (March 2000): 223–26. http://dx.doi.org/10.1086/501750.

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AbstractA retrospective review of methicillin-resistant Staphylococcus aureus isolates from the Naval Medical Center, San Diego, for the years 1994 through 1997, found that the annual number of community-acquired MRSA isolates increased during the period. These outpatient isolates were more likely than inpatient isolates to be sensitive to a greater number of antibiotics.

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Aviña Cerecer, Gustavo. "The Dispossessed of Necropolitics on the San Diego-Tijuana Border." Social Sciences 9, no. 6 (May 29, 2020): 91. http://dx.doi.org/10.3390/socsci9060091.

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This article presents results of a first-hand investigation that took a year of ethnographic work (methods of observation and interviews) during 2016–2017, with the post-structural theoretical framework of Gilles Deleuze, on the United States–Mexico border, in the San Diego-Tijuana corridor. The Center for Iberian and Latin American Studies of the University of California San Diego, PREVENCASA A. C., and Universidad Autónoma de San Luis Potosi supported this research. In this research, statistical data, observations, and synthesis of in-depth interviews were utilized about those defined as the ‘dispossessed’: users of hard drugs, and/or in homelessness conditions of discrimination in a highly contrasting border such as that of the United States and Mexico. Among the main results are the relations between mental and embodiment limits, necropolitics and territory, as well as the approach of post-structural political discourses about the body and mind that allow us to understand the subjectivities in question, proposing two types of homelessness.

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Woo, Benjamin, Brian Johnson, Bart Beaty, and Miranda Campbell. "Theorizing comic cons." Journal of Fandom Studies 8, no. 1 (March 1, 2020): 9–31. http://dx.doi.org/10.1386/jfs_00007_1.

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When comics fandom emerged as a distinct media-oriented community in the 1960s, one of the things it brought with it from science-fiction fandoms was the convention. Buoyed by the synergistic relationship between Hollywood and the San Diego Comic-Con and the growing prominence of ‘geek’ culture, comic conventions, comic art festivals and related media fandom events across North America have enjoyed enhanced prestige, attention and attendance over the last fifteen to twenty years. But what kind of event are these ‘con events’? This article builds on a cultural mapping survey of convention organizers. The survey’s goal was to suggest something of the scope and diversity of the contemporary sector. Behind this variation, we define the con event as an organizational and cultural form that is (1) oriented to media, (2) audience-facing and (3) concerned with circulation.

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Sierra, Christine Marie. "Latino Politics in California. Edited by Aníbal Yáñez Chávez. San Diego: Center for U.S.-Mexican Studies, University of California, San Diego, 1996. 142p. $12.95." American Political Science Review 92, no. 2 (June 1998): 475–76. http://dx.doi.org/10.2307/2585720.

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