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Статті в журналах з теми "Salivary gland mass"
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Bourgeois, Jacqueline M., Jasim Radhi, Lisa Elden, and Gerald Gill. "Plexiform Neurofibroma of the Submandibular Salivary Gland in a Child." Canadian Journal of Gastroenterology 15, no. 12 (2001): 835–37. http://dx.doi.org/10.1155/2001/675485.
Повний текст джерелаАнотація:
Plexiform neurofibromas in major salivary glands are rarely described. In the literature, most reported tumours have been present in the parotid gland region. A three-year-old boy with a family history of neurofibromatosis presented with a rapidly growing left submandibular mass. The clinical diagnosis was that of a neurofibroma rather than a primary salivery gland tumour. Resection of the lesion revealed a plexiform neurofibroma involving the submandibular gland. Although these tumours have a neurogenic rather than a salivary gland origin, they must be considered in the differential diagnosis of a salivary gland lesion in a patient with a history of neurofibromatosis.
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Ribeiro, J. M. "Characterization of a vasodilator from the salivary glands of the yellow fever mosquito Aedes aegypti." Journal of Experimental Biology 165, no. 1 (April 1, 1992): 61–71. http://dx.doi.org/10.1242/jeb.165.1.61.
Повний текст джерелаАнотація:
Salivary gland homogenates and oil-induced saliva of the mosquito Aedes aegypti dilate the rabbit aortic ring and contract the guinea pig ileum. The vasodilatory activity is endothelium-dependent, heat-stable, sensitive to both trypsin and chymotrypsin treatments, and both smooth muscle activities cross-desensitize to the tachykinin peptide substance P. Both bioactivities co-elute when salivary gland homogenates are fractionated by reversed-phase HPLC. Molecular sieving chromatography indicates a relative molecular mass of 1400. A monoclonal antibody specific to the carboxy terminal region of tachykinins reacts with material in the posterior part of the central lobe of paraformaldehyde-fixed salivary glands. The presence of a vasodilatory peptide of the tachykinin family in the salivary glands of A. aegypti is proposed and its role in blood feeding is discussed.
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Lokesh, Lokesh, Smita Manchanda, Ashu Seith Bhalla, and Barun Bagga. "Unilateral submandibular gland aplasia with contralateral hypertrophy: an unusual neck mass." BMJ Case Reports 14, no. 2 (February 2021): e240835. http://dx.doi.org/10.1136/bcr-2020-240835.
Повний текст джерелаАнотація:
The congenital absence of major salivary glands is an infrequent disorder, in which several glands are usually involved at the same time. Aplasia of unilateral submandibular (SM) gland is a very rare finding. Clinical presentation is variable. While some patients have no symptoms, others report difficulty in chewing and swallowing due to dry mouth, and even dental caries. Diagnosis of salivary gland aplasia can be made with a variety of imaging techniques, which include sonography, CT or MRI, sialography or isotope scans (technetium T99m-pertechnetate). We report the case of a 30-year-old man presenting with a gradually progressive neck mass, because of unilateral SM gland hypertrophy associated with contralateral SM gland aplasia.
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Lau, D. P. C., M. J. Goddard, I. D. Bottrill, and D. A. Moffat. "Epithelial-myoepithelial carcinoma of the parotid gland. An unusual cause of ear canal stenosis." Journal of Laryngology & Otology 110, no. 5 (May 1996): 493–95. http://dx.doi.org/10.1017/s0022215100134085.
Повний текст джерелаАнотація:
AbstractEpithelial-myoepithelial carcinoma (EMC) accounts for approximately one per cent of salivary gland tumours. This tumour is gaining wider recognition following inclusion into the WHO histological classification of salivary gland tumours in 1990. Salivary gland tumours characteristically present with an enlarging mass. We describe an unusual presentation of a salivary gland tumour with stenosis of the external ear canal in the absence of a palpable mass. EMC usually arises from the salivary glands but isolated cases have been described arising primarily from the paranasal sinuses, trachea and lacrimal gland. The management of this tumour is still evolving with surgical excision being the main-stay of treatment. The efficacy of radiotherapy has not yet been established but high local recurrence rates despite apparently adequate excision and the possibility of a multicentric origin of the tumour may herald an increasing role for radiotherapy in the future. We stress the importance of awareness of adjacent structures when considering the cause of cartilaginous canal stenosis.
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Kessler, Alexander T., and Alok A. Bhatt. "Review of the Major and Minor Salivary Glands, Part 2: Neoplasms and Tumor-like Lesions." Journal of Clinical Imaging Science 8 (November 15, 2018): 48. http://dx.doi.org/10.4103/jcis.jcis_46_18.
Повний текст джерелаАнотація:
The salivary glands are small structures in the head and neck, but can give rise to a wide variety of benign and malignant pathology. When this occurs, patients may present with palpable swelling, although it is quite common that they are asymptomatic and a salivary gland mass was discovered as an incidental finding on imaging performed for another reason. It is, therefore, critical that radiologists pay careful attention to the salivary glands and have working knowledge of the key differentiating features of the most common neoplastic and nonneoplastic etiologies of salivary gland masses. The purpose of this review is to provide a succinct image-rich article illustrating the various causes of salivary gland masses via an extensive review of the primary literature. In Part 2, we discuss neoplasms and tumor-like lesions of the salivary glands with a key emphasis on specific imaging features of the most common pathologic entities.
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Ugur, Kader, and Suleyman Aydin. "Saliva and Blood Asprosin Hormone Concentration Associated with Obesity." International Journal of Endocrinology 2019 (March 27, 2019): 1–8. http://dx.doi.org/10.1155/2019/2521096.
Повний текст джерелаАнотація:
Background. The aim was to investigate the amounts of saliva and serum asprosin in order to determine whether it is related to obesity and whether salivary glands synthesize asprosin or not.Methods. A total of 116 underweight, normal weight, overweight, and obese (class I, class II, and class III) volunteers participated in the study. Saliva and blood samples were collected simultaneously from the participants. The amounts of asprosin in saliva, salivary gland tissue supernatants, and bloods were determined by ELISA, whereas asprosin synthesis sites of salivary gland tissues were determined immunohistochemically.Results. The amount of asprosin from the lowest to the highest was in the order as follows: underweight, normal weight (control), overweight, and obese classes I and III. The lowest level of asprosin was detected in underweight individuals. It was also found that the interlobular striated ducts and the interlobular ducts of the submandibular and parotid salivary glands produce asprosin. According to these data, the asprosin level is related with obesity as the amount increases in accordance with increasing body mass index (BMI). On the other hand, there is also a relationship between the underweight and asprosin because the amount decreases with BMI decrease.Conclusions. Asprosin, a new adipokine, may be a novel indicator of adipose tissue mass. Therefore, we anticipate that antiasprosin preparations may be an alternative in the treatment of obesity in the future.
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Wahida, O. Nurul, and Paul D. Cooper. "Feeding and the salivary gland response in free-ranging yellow-winged grasshoppers (Gastrimargus musicus)." Australian Journal of Zoology 62, no. 5 (2014): 393. http://dx.doi.org/10.1071/zo14068.
Повний текст джерелаАнотація:
Yellow-winged grasshoppers (Gastrimargus musicus) were captured in the field to examine the morphology and amine immunohistochemistry of their salivary glands. Fifty-eight grasshoppers were collected, with only five being males. Eight of 53 female grasshoppers had food in their crop, and the salivary glands of those insects were significantly heavier than those of grasshoppers without food in their crops. The salivary gland of the yellow-winged grasshopper was an acinar-type gland, similar to gland descriptions for other Orthoptera. The primary secretory part of acini of each gland is composed of zymogen and parietal cells. Staining patterns indicated that serotonin and dopamine could act as neurotransmitters and/or neurohormones to stimulate the glands. The pattern of staining of serotonin in the salivary gland suggested that serotonin stimulates both zymogen and parietal cells. Only the parietal cells were positively stained with dopamine. Comparing staining of glands of grasshoppers with food in their crop with the glands of grasshoppers with empty crops suggested a reduction in staining for serotonin in the latter. The differential staining pattern suggests that these amines have different roles in the salivary gland of G. musicus. The lack of difference in structure but increased mass with feeding suggests that all glands were active, but that secretion was actively occurring only in animals with the heavier glands.
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Barbosa, António, Álvaro Rodrigues, Teresa Corrales, and Sónia Viegas. "Myoepithelioma of Minor Salivary Gland: A Case Report." European Journal of Dental and Oral Health 3, no. 4 (September 18, 2022): 4–5. http://dx.doi.org/10.24018/ejdent.2022.3.4.131.
Повний текст джерелаАнотація:
Introduction: The myoepithelioma is a rare form of salivary glands tumors. The conservative surgery is the treatment of choice. Case Report: 49 years old male with a submucosa mass of the inferior lip with over 20 years of evolution without progressive growth, bleeding or pain. The patient had no risk factors except history of smoking (34 pack-years). At physical examination the patient presented a consistent submucosa mass of the inferior lip at the right, mobile, painless and without visual signs of abnormal mucosa over the mass. An excisional biopsy was performed and the piece had a reniform shape and rubberish consistency with 30 x16 mm dimension. The histology exam revealed a myoepithelioma of minor salivary gland. Discussion: Tumors with an exclusive constitution of myoepithelial cells are rare. The majority is located at parotid gland. Conclusion: Myoepithelioma of minor salivary glands are rare and the number of reported cases is limited. The differential diagnosis with pleomorphic adenoma is important.
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FAIZAL, Felice, Ankur AHUJA, and R. CHATTERJEE. "Pleomorphic Adenoma of Three Different Sites: a Consecutive Case Series." Medicina Moderna - Modern Medicine 28, no. 2 (June 30, 2021): 253–56. http://dx.doi.org/10.31689/rmm.2021.28.2.253.
Повний текст джерелаАнотація:
Background: Pleomorphic adenomas are benign salivary gland tumors predominantly arising from the superficial lobe of the parotid gland and rarely from the small salivary glands located at various locations including parotid, lacrimal duct, lip, floor of the mouth etc. Surgical excision of the tumor mass is the treatment of choice with utmost care taken to preserve the facial nerve in cases involving the parotid gland. Case details: This case series highlights three consecutive cases of pleomorphic adenoma arising from three different locations. Conclusion: Pleomorphic adenoma is the commonest salivary gland tumor characterized by diverse histomorphological features and can occur at any site where salivary tissue is present. Careful histopathological analysis should be done in all tumors arising especially in the head and neck region.
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Muddaiah, Dechu, Srinivas Venkatarangaiah, Prashanth V, and Mohammed Adil Hussain M. "Schwannoma of the Submandibular Gland." Bengal Journal of Otolaryngology and Head Neck Surgery 28, no. 1 (April 30, 2020): 80–83. http://dx.doi.org/10.47210/bjohns.2020.v28i1.178.
Повний текст джерелаАнотація:
Introduction
Mesenchymal tumours of submandibular gland are extremely rare. Schwannoma of the salivary glands is a particularly rare form of an extracranial neurogenic tumour.
Case Report
Here, we present an unusual case of schwannoma of submandibular gland in a 16 year old girl, who underwent total excision of mass with submandibular gland excision with no cranial nerve deficits. The details of the histopathologic features are present .
Discussion
Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumour. Our case indicates good prognosis in a case of submandibular gland schwannoma after surgical excision.
Дисертації з теми "Salivary gland mass"
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Jones, Matthew Leslie. "The subnuclear localisation of Notch responsive genes." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274909.
Повний текст джерелаАнотація:
Title: The subnuclear localisation of Notch responsive genes. Candidate Name: Matthew Jones Notch signalling is a highly conserved cell-cell communication pathway with critical roles in metazoan development and mutations in Notch pathway components are implicated in many types of cancer. Notch is an excellent and well-studied model of biological signalling and gene regulation, with a single intracellular messenger, one receptor and two ligands in Drosophila. However, despite the limited number of chemical players involved, a striking number of different outcomes arise. Molecular studies have shown that Notch activates different targets in different cell types and it is well known that Notch is important for maintaining a stem cell fate in some situations and driving differentiation in others. Thus some of the factors affecting the regulation of Notch target genes are yet to be discovered. Previous studies in various organisms have found that the location of a gene within the nucleus is important for its regulation and genome reorganisation can occur following gene activation or during development. Therefore this project aimed to label individual Notch responsive loci and determine their subnuclear localisation. In order to tag loci of interest a CRISPR/Cas9 genome-editing method was established that enabled the insertion of locus tags at Notch targets, namely the well-characterized Enhancer of split locus and also dpn and Hey, two transcription factors involved in neural cell fate decisions. The ParB/Int system is a recently developed locus tagging system and is not well characterised in Drosophila. It has a number of advantages over the traditional LacO/LacI-GFP locus tagging system as it does not rely on binding site repeats for signal amplification and can label two loci simultaneously in different colours. This thesis characterised the ParB/Int system in the Drosophila salivary gland and larval L3 neuroblast. Using 3D image segmentation hundreds of nuclei were reconstructed and a volume based normalisation method was applied to determine the subnuclear localisation of several Notch targets with and without genetic manipulations of the Notch pathway.
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Soumya. "Accuracy of core needle biopsy compared to fine needle biopsy for the diagnosis of malignancy in patients with suspected head and neck cancers: A systematic review and meta-analysis of diagnostic test accuracy and comparison of adverse effects." Thesis, 2020. http://hdl.handle.net/2440/126065.
Повний текст джерелаАнотація:
Objective: The objective of this review was to compare the diagnostic accuracy of core needle biopsy and fine needle aspiration cytology for patients with a head and neck mass for a diagnosis of malignancy using surgical histopathology as a reference test and to compare the risks and adverse events associated with each technique. Introduction: A proportion of head and neck neoplasms are malignant which can only be determined by a tissue diagnosis. Options for tissue biopsy include - surgical biopsy, fine needle aspiration (FNA), and core needle biopsy (CNB). Insufficient tissue for a diagnosis results in additional delays in patient management. The diagnostic sensitivity and specificity of each option for tissue biopsy in diagnosing a head and neck malignancy has not been evaluated in a meta-analysis. Our review aimed to compare and review the diagnostic accuracy of FNA and CNB for head and neck lesions and assess the risk and adverse events associated with each technique. Inclusion criteria: Studies that compared ultrasound guided CNB and/or FNAC to investigate lumps suspicious for head and neck malignancy in thyroid, cervical lymph nodes, or salivary gland in adult patients were included. The comparator test was definitive histology in the form of surgical biopsy/excision. Methods MEDLINE, EMCARE, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews were searched. Studies were critically appraised by two independent reviewers for methodological quality using the modified critical appraisal instrument QUADAS2 using JBI – SUMARI software. Data was extracted from papers included in the review using a modified data extraction tool available in the JBI Reviewer’s Manual. Meta-analysis was performed using a random-effects model. Comparison of accuracy of the two techniques was achieved by comparing pooled sensitivity and specificity using a bivariable model. The inadequacy rate and inconclusive rate were also pooled for comparison. Summary receiver operating characteristic (ROC) graphs were created to confirm diagnostic accuracy. Narrative review of adverse effects was conducted. Results: Majority of the patients in the included studies compared FNA and CNB for thyroid masses. Data on a total of 1229 patients for FNA and 1135 patients for CNB from six studies met the inclusion criteria and were included in the final meta-analysis. The studies were of moderate-low or unknown quality. While CNB and FNA had similar sensitivity and specificity in diagnosing thyroid malignancy, the non-diagnostic and inadequacy rate for CNB was significantly lower: sensitivity 0.91 (95% CI: 0.79 to 0.96) vs 0.75 (95% CI: 0.66 to 0.83) respectively, specificity 1.00 (95% CI: 0.98 to 1.00) vs 1.00 (95% CI: 0.60 to 1.00) respectively, non-diagnostic rate 0.043 (95% CI: 0.016 to 0.07) vs 0.164 (95% CI: 0.083 to 0.245) respectively, inadequacy rate 0.112 (95% CI: 0.087 to 0.137) vs 0.17 (95% CI: 0.106 to 0.233) respectively (p<0.001). There were no substantial differences in complication rates noted. Conclusion: Sensitivity and specificity of FNA and CNB for diagnosis of thyroid malignancy for FNA and CNB are high. The inadequacy rate and inconclusive rate for CNB is lower than FNA for thyroid malignancy. CNB could be used instead of FNA for diagnosis of thyroid nodules if found to be cost effective. These results need to be treated with caution as the methodological quality of included studies was generally poor, introducing a high risk of bias; while substantial differences in study characteristics resulted in significant between study heterogeneity. Further verification of these results with high quality studies is required.Thesis (MClinSc) -- University of Adelaide, School of Public Health, 2020
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BUČINSKÁ, Lenka. "Analýza glykoproteinů ze slinných žláz klíštěte \kur{Ixodes ricinus}." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-52563.
Повний текст джерелаАнотація:
I characterized several potential glycoproteins in salivary gland extracts from unfed and partially fed females of ticks Ixodes ricinus using enzyme deglycosylation and lectin labeling. Affinity-based (chromatografic) analysis was applied for isolations of glycoproteins with specificity for GNA (mannose), HPA (N-acetylgalactosamine) and MAA II (sialic acid) lectins. GNA specific 120 kDa glycoprotein was isolated from partially fed females and is modified with N-linked glycans containing {$\alpha$}1,3-mannose. Mass spectrometry analyses confirmed the presence carboxypeptidase M in elution fraction gain with GNA affinity chromatography. GNA specific proteins were purified from unfed female salivary gland extracts. MS analyses identified them as proteins similar to arylsulfatase B and cytoskeletal Sojo protein. Proteins (85 and 56 kDa) isolated with HPA affinity chromatography were characterized as Trappin 12, which is a host protein. MAA II lectin was used for labelling and isolation of 100 kDa protein. N-terminal sequence of the MAA II specific protein predicted similarity with a host protein, Siglec 1. Fucose in salivary gland extract was detected with the labelling of AAA, AAL, UEA I and LTL lectins. Results showed that salivary gland extracts contain {$\alpha$}1,2-; {$\alpha$}1,3- and {$\alpha$}1,6- N-linked fucose and O-linked fucose probably as well. GNA specific proteins were detected in partially fed salivary glands acini type II and III using electron transmission microscopy. Fucose was detected on gut and salivary gland structures using fucose-specific lectin AAL.
Частини книг з теми "Salivary gland mass"
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Hellquist, Henrik, and Alena Skalova. "Mammary Analogue Secretory Carcinoma (MASC)." In Histopathology of the Salivary Glands, 363–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-540-46915-5_14.
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Lequerica-Fernández, Paloma, Ignacio Peña, Fernando Sánchez Lasheras, Francisco Javier Iglesias Rodrigez, Carlos González Gutiérrez, and Juan Carlos De Vicente. "Outcome Prediction for Salivary Gland Cancer Using Multivariate Adaptative Regression Splines (MARS) and Self-Organizing Maps (SOM)." In International Joint Conference SOCO’17-CISIS’17-ICEUTE’17 León, Spain, September 6–8, 2017, Proceeding, 361–70. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67180-2_35.
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"Applied Physiology of the Parotid Gland." In Diagnostic Techniques and Therapeutic Strategies for Parotid Gland Disorders, 24–33. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5603-0.ch004.
Повний текст джерелаАнотація:
The major function of salivary glands is the production of saliva, which performs many functions including lubrication of the food bolus, maintaining the oral cavity pH within 6 to 7, maintaining teeth integrity, fighting bacteria, aiding taste and digestion, and providing a continuous lavaging biofilm for the oral cavity. Saliva is actively produced in high volumes relative to the mass of the salivary glands and is almost completely controlled extrinsically by both parasympathetic and sympathetic divisions of the autonomic nervous system. Some researchers used bilateral tympanic neurectomy for patients with ptyalism (drooling) with good initial results. Others advocated bilateral parotid duct rerouting ± bilateral submandibular gland excision for long-term treatment of drooling. Intra-glandular Botulinum toxin may also have good results for patients with hyper-sialorrhea. Most resting salivary gland flow arises from the submandibular glands and surgery should focus on this gland to control uncontrolled sialorrhea.
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"Evaluation of the Parotid Gland." In Diagnostic Techniques and Therapeutic Strategies for Parotid Gland Disorders, 34–59. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5603-0.ch005.
Повний текст джерелаАнотація:
This chapter describes the clinical, laboratory, imaging, endoscopic, and histological methods for evaluation of the parotid gland. Diagnostic approaches of parotid gland disorders include clinical evaluation in the form of history-taking (complaints, demographic data, medical profile, medications, and history of the parotid mass itself) and physical examination (intra-oral, extra-oral, and bidigital examination). Laboratory tests entail saliva collection for detection of changes in salivary flow and/or composition. Parotid gland imaging include plain x-ray, sialography, ultrasound (US), computed tomography (CT) scan and CT-sialography, magnetic resonance imaging (MRI), and MR-sialography. Other studies include endoscopy (sialoendoscopy) and parotid biopsy (core-biopsy, frozen-section) and fine needle aspiration cytology (FNAC).
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"Benign Tumors of the Parotid Gland." In Diagnostic Techniques and Therapeutic Strategies for Parotid Gland Disorders, 175–94. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5603-0.ch011.
Повний текст джерелаАнотація:
Benign tumors of the salivary glands are varied and named after their cell type. They occur most commonly in the parotid gland, and the majority (approximately 80%) are pleomorphic adenoma. This benign tumor arises from the superficial lobe of the gland in approximately 80% of cases. Less commonly, the mass presents as a cheek mass overlying the masseter muscle, arising from the accessory parotid lobe. If the tumor arises from the deep lobe, it presents as a para-pharyngeal mass with a completely different clinical presentation. In this instance, the patient will complain of snoring and difficultly in swallowing. Physical examination will reveal a soft palate and tonsillar, diffuse bulge, which is firm in consistency. Malignant transformation is extremely rare. Ultrasonography, computed tomography scan and magnetic resonance imaging are the best imaging tools. Treatment is usually through superficial or total conservative parotidectomy, with preservation of the facial nerve.
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Abd-Alla, A. M. M., M. H. Kariithi, and M. Bergoin. "Managing Pathogens in Insect Mass-Rearing For the Sterile Insect Technique, With the Tsetse Fly Salivary Gland Hypertrophy Virus as an Example." In Sterile Insect Technique, 317–54. CRC Press, 2020. http://dx.doi.org/10.1201/9781003035572-10.
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Mitchell, Graham. "The Machinery of Digestion." In How Giraffes Work, 147–86. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197571194.003.0008.
Повний текст джерелаАнотація:
This chapter discusses the machinery of digestion in giraffes. The shape of the mouth of giraffes, the shape and number of their teeth, the shape and size of their tongue and the arrangement of the muscles of eating are unique and have evolved to be perfectly suited to the task of browsing. Comminution of browse is eased by large volumes of saliva secreted from salivary glands that relative to body mass are small. The digestive tract of giraffes consists of a rumen, reticulum, and omasum in addition to the usual stomach and intestines found in any mammal. The forestomachs are smaller and the small and large intestines are longer than those of grazer-ruminants. The quality, succulence and consistency of browse reduces the need for prolonged rumination. Movement of browse through the rumen-reticulum is fast, and it is likely that a mixture of plant cell contents and saliva, can bypass the rumen via an esophageal groove, and be deposited directly into the stomach. 40% of daily energy (mainly in the form of volatile fatty acids) is provided by microbial fermentation of browse in the rumen, and 60% derives from intestinal digestion mainly of glucose), rather than the reverse as found in grazer-ruminants. Significant fermentation of undigested fiber (mainly hemicellulose) occurs in the large intestine. The combination of digestive processes results in very efficient use of the nutrients and an apparent digestibility of ~85%, which is high. To provide the browse needed to meet daily energy demand giraffes need a home range of ~60 km2.
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Turner, Helen E., Richard Eastell, and Ashley Grossman. "Principles of endocrinology." In Endocrinology (Oxford Desk Reference), 1–24. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199672837.003.0001.
Повний текст джерелаАнотація:
This chapter discusses the principles of endocrinology, starting with a description of the anatomy of endocrine glands, hormone structures, and hormone receptors. It similarly provides information on hormone measurements, such as immunoassays, mass spectrometry, hormonal-binding proteins, and biological matrices from serum, urine, and saliva. It relates autoimmunity to the endocrine system, and provides examples of studies of genetic endocrine disorders, such as linkage studies, complex endocrine disease-related case control studies, and genome-wide association studies. Providing information on the endocrine epidemiology, this chapter describes ethnic and geographic variation in disorders such as iodine deficiency, thyroid cancer, vitamin D deficiency, pituitary disease, diabetes, and multiple endocrine neoplasia.
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Farne, Hugo, Edward Norris-Cervetto, and James Warbrick-Smith. "Neck lump." In Oxford Cases in Medicine and Surgery. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780198716228.003.0010.
Повний текст джерелаАнотація:
Considering the anatomy and associated pathology, the lump may represent: • Artery: carotid artery aneurysm, subclavian artery aneurysm, carotid body tumour (i.e. chemodectoma or paraganglioma of the carotid body) • Nerves: neurofibroma, schwannoma • Lymphatics: lymphatic malformations • Lymph nodes: infective, neoplastic (primary or metastatic), granulomatous • Salivary glands: infective, autoimmune, neoplastic • Larynx: laryngocele • Pharynx: pharyngeal pouch • Branchial arch remnant: branchial cyst/sinus/fistula • Skin/superficial subcutaneous: lipoma, epidermal cyst, abscess, dermoid cyst • Muscle/cartilage/bone: sarcomas (e.g. rhabdomyosarcoma, fibrosarcoma, osteosarcoma), cervical rib, torticollis The age of the patient has an enormous bearing upon the pathology you should expect to encounter: • In children, about 75% of neck lumps are benign. Congenital and inflammatory lumps are most common. Thus the differential diagnosis will be weighted in favour of branchial cleft cysts, lymphatic malformations, and lymphadenitis. If malignancy is diagnosed in paediatric neck lumps, it is usually a lymphoma or sarcoma, or sometimes a papillary thyroid carcinoma. • In adults over 40, as many as 75% of lateral neck lumps are malignant. Of the malignant neck lumps, about 80% are metastases and the rest are mostly lymphomas. In fact, ▲ in the absence of signs of infection, a lateral neck mass in an adult is lymphadenopathy due to metastatic carcinoma (usually squamous cell) until proven otherwise. • How long has the lump been there? ■ Less than a few weeks: most likely infective or inflammatory lymphadenopathy, although some patients will present with malignant neck lumps that have only been noticed within the last few days. ■ More than a few weeks: must exclude malignancy. ■ Years, with little change: most likely benign. ■ Note that congenital neck lumps, despite being ‘congenital’, may only ‘appear’ later in life as they may fluctuate in size (e.g. following an infection). • Has the lump got bigger, smaller, or stayed the same size? A lump that is gradually increasing in size must be regarded as a malignancy until proven otherwise. Remember that a progressive increase in size of a malignant neck lump may be reported as a sudden appearance by the patient.
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Robinson, Max, Keith Hunter, Michael Pemberton, and Philip Sloan. "Diseases of the oral mucosa." In Soames' & Southam's Oral Pathology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199697786.003.0007.
Повний текст джерелаАнотація:
The oral mucosa lines the oral cavity and comprises a surface squamous epithelium with underlying lamina propria. Below the mucosa is the submucosa, which is composed of fibrous tissue and adipose tissue, and contains lobules of minor salivary glands and neurovascular bundles. In places, there is no submucosa and the lamina propria is continuous with periosteum, forming the resilient mucoperiosteum that covers the maxilla and mandible. The squamous epithelium is composed of keratinocytes arranged in layers: there is a basal cell layer that rests on the basement membrane, a prickle cell layer, and usually a keratinized layer. The keratinocytes are attached to each other by desmosomes and the basal keratinocytes are attached to the basement membrane by hemi- desmosomes. The basement membrane is important in maintaining the integrity of the mucosa by sticking the squamous epithelium to the underlying lamina propria. There are two patterns of keratinization: parakeratosis and orthokeratosis. In parakeratinized epithelium the surface keratinocytes become flattened and the nucleus becomes dark and shrunken (pyknotic). These terminally differentiated squamous cells are eventually lost at the surface by desquamation. In orthokeratinization, there is a granular cell layer (containing numerous keratohyaline granules) between the prickle cell layer and the keratinized layer. The surface squames become flattened and do not contain any discernible nuclear material. Whilst the majority of cells in squamous epithelium are keratinocytes, there are also accessory cells such as melanocytes, Langerhans cells, and neurosensory cells (Merkel cells and taste buds). The lamina propria is the connective tissue that lies immediately below the epithelium. It is divided into the superficial papillary layer (sometimes referred to as the corium) and the deeper reticular layer. The lamina propria is composed of fibrous tissue with a rich neurovascular supply and contains fibroblasts that elaborate collagen and elastin fibres along with other extracellular matrix proteins. The lamina propria also contains components of the mucosal immune defence system such as Langerhans cells, macrophages, mast cells, and lymphocytes. The clinical appearance of the oral mucosa is dependent on the thickness of the epithelium, the amount of surface keratinization, melanin (and other) pigmentation, and the vascularity of the lamina propria.
Тези доповідей конференцій з теми "Salivary gland mass"
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Li, Wanze, Zhuoqun Zhang, Zhuohong He, Parth Vora, Alan Lai, Balazs Vagvolgyi, Simon Leonard, et al. "Progress in Development of an Automated Mosquito Salivary Gland Extractor: A Step Forward to Malaria Vaccine Mass Production." In 2021 IEEE 17th International Conference on Automation Science and Engineering (CASE). IEEE, 2021. http://dx.doi.org/10.1109/case49439.2021.9551500.
Повний текст джерела
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Leffers, D., C. Idel, L. Tharun, S. Perner, and K.-L. Bruchhage. "(Mammary analog) Secretory Carcinoma (MASC) of the salivary glands." In 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1728911.
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Costa, Raisa Ferreira, and Claúdia Malheiros Coutinho Camillo. "TUMORES DE GLÂNDULAS SALIVARES: MODELOS PDX E CULTURA DE CÉLULA." In I Congresso Nacional Multidisciplinar de Oncologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1553.
Повний текст джерелаАнотація:
Introdução: Tumores de glândula salivares são raros e poucos frequentes, e apresentam quantidade de lesões diferentes dificultando o diagnóstico desta doença. O tratamento para essas neoplasias requer cirurgia e radioterapia e para o tratamento metastático, a quimioterapia. Essas poucas opções de tratamento ainda apresentam baixa taxa de sobrevida. Objetivos: O presente estudo de revisão narrativa objetivou abordar mecanismos possíveis envolvidos na gênese dos tumores, usando como base o uso de modelos experimentais como o modelo PDX e cultura de célula para o tratamento e diagnóstico precoce, possível para esses tumores. Materiais e métodos: Foi realizado um levantamento na literatura, no período de 2015 a 2021, em diferentes bases de dados, SciELO, da U.S. National Library of Medicine e do National Institutes Health (PubMed) e das bases de dados Web of Science. Como estratégia de busca, foram utilizados os seguintes termos: "Salivary gland tumors" and "model experiments" selecionados em consulta com o Medical Subject Headings (MeSH). 19 artigos foram selecionados para esta revisão. Resultados: Estudos apontam que há poucos modelos celulares disponíveis e considerando as opções de terapia personalizada e terapias-alvo, torna-se fundamental o desenvolvimento de novos modelos para identificação das alterações moleculares e a elucidação do papel delas nestes tumores, permitindo o delineamento de terapêuticas mais adequadas para cada caso e o entendimento da fisiopatologia da tumorigênese. Conclusão: Sendo assim, sugere-se que esses modelos conseguem replicar a heterogeneidade dos tumores com o dos pacientes, podendo ser uma ferramenta importante de pesquisa para se melhor entender os eventos da tumorigênese, a morfologia e biologia tumoral e a identificação de perfis de expressão gênica e alterações moleculares para o desenvolvimento de novas abordagens terapêuticas para os tumores de glândulas salivares.
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Pratt, Sheila Alhana, Valeria Sanabria, Ana Soskin, Aurora Rocio Rizzi, and Marcos Cabrera. "ADENOID CYSTIC CARCINOMA OF THE BREAST." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1014.
Повний текст джерелаАнотація:
Introduction: Adenoid cystic adenoid carcinoma (ACC) of the breast is a rare variant that occurs in large series only in less than 1% of the patients. It has favorable prognosis and morphological resemblance to tumors originating in the salivary glands. Histopathological diagnosis is based on a mixture of proliferating glands, which correspond to the adenoid component and the replication of the basal membrane in the form of cylinders established by the pseudoglandular component. It usually occurs in adult women. Its form of clinical presentation is a painless breast nodule, located in the retroareolar region, without compromise of skin or nipple secretion, of small size and circumscribed limits. Treatment of ACC is not protocolized, although it is accepted that conservative surgery is applicable in most cases. Our goal is to publicize the clinical case of a patient treated in our service and to show some clinical and histopathological aspects of this same rare pathology. Case report: 63-year-old patient, with no history of cancer in the family, menarche at 16 years of age, three full births, 24 months of lactation, menopause at 46 years of age, no hormone replacement therapy. Hypertensive and diabetic, a right breast nodule was self-detected six months before; slow and painless growth that then fistulizes the skin and is accompanied by serohematic secretion of a gelatinous consistency. On physical examination, a 7 cm nodule is felt in lower quadrants, showing elastic consistency and poorly defined edges. No adenopathies in the armpits or neck. Sectional biopsy performed in another service. Pathological anatomy: differential diagnosis between Cystic Hypersecretory Carcinoma and Cystic Secretory Hyperplasia. With the diagnosis of ACC of the right breast, T2N0Mx stage IIa. Mammography: breasts type b, at the junction of lower quadrants of the right breast, dense delimited mass measuring 5x4 cm, no retraction or skin edema. BIRADS V. Ecograph: A mass located in H6 to 3 cm of the nipple with well delimited edges, with heterogeneous characteristics with liquid and solid areas of 5.71 cm x 4.06 cm. BIRADS V. Extensive resection and sentinel node biopsy is performed. Histopathological result revealed ACC G1 of 5.5 cm with no associated in situ carcinoma. No vascular plungers or perineural invasion are observed. Free surgical limits. pT3 Nx.Mx. Immunohistochemistry: RE-; RP-; HER2-;ki67 <14%. Our case showed a neoplastic proliferation consisting of two types of cavity formation; true glandular lights (adenoid component) and pseudo lumens that produce basal membrane material (cylinder component) with eosinophilic basal membrane material, the adenoid component with basophilic mucin and surrounded by myoepithelial cells. Three negative lymph nodes metastasis. Radiation therapy was decided as an adjuvant treatment.