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1

Terner, Jordan S., Roberto Travieso, Su-shin Lee, Antonio J. Forte, Anup Patel, and John A. Persing. "Combined metopic and sagittal craniosynostosis: is it worse than sagittal synostosis alone?" Neurosurgical Focus 31, no. 2 (August 2011): E2. http://dx.doi.org/10.3171/2011.6.focus11100.

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Object Combined metopic and sagittal craniosynostosis is a common variant of the nonsyndromic, multiplesuture synostoses. It is unknown whether this combined form causes reduced intracranial volume (ICV) and potentially more brain dysfunction than sagittal synostosis alone. This study is a volumetric comparison of these 2 forms of craniosynostosis. Methods The authors conducted a retrospective chart and CT review of 36 cases of isolated sagittal synostosis or combined metopic and sagittal synostosis, involving patients seen between 1998 and 2006. Values were obtained for the intracranial compartment, brain tissue, CSF space, and ventricular volumes. Patients with craniosynostosis were then compared on these measures to 39 age- and sex-matched controls. Results In patients with isolated sagittal synostosis and in those with combined metopic and sagittal synostosis, there was a trend toward smaller ICV than in controls (p < 0.1). In female patients older than 4.5 months of age, there was also a trend toward smaller ICV in patients with the combined form than in those with sagittal synostosis alone (p < 0.1), and the ICV of patients with the combined form was significantly smaller than the volume in controls in the same age group (p < 0.05). Brain tissue volume was significantly smaller in both patient groups than in controls (p < 0.05). Ventricular volume was significantly increased (compared with controls) only in the patients with isolated sagittal synostosis who were younger than 4.5 months of age (p < 0.05). Overall CSF space, however, was significantly larger in both patient groups in patients younger than 4.5 months of age (p < 0.05). Conclusions These findings raise concerns about intracranial and brain volume reduction in patients with sagittal and combined metopic and sagittal synostoses and the possibility that this volume reduction may be associated with brain dysfunction. Because the ICV reduction is greater in combined metopic and sagittal synostosis in patients older than 4.5 months of age than in sagittal synostosis in this age group, the potential for brain dysfunction may be particularly true for these younger infants.
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2

Jane, John A., Kant Y. Lin, and John A. Jane. "Sagittal synostosis." Neurosurgical Focus 9, no. 3 (September 2000): 1–6. http://dx.doi.org/10.3171/foc.2000.9.3.4.

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Sagittal synostosis causes predictable malformations depending on the specific suture location that fuses. Anterior fusion causes frontal bossing, whereas posterior fusion causes an occipital knob. Complete sagittal synostosis results in deformity both anteriorly and posteriorly. Variants of each type exist and therefore surgical correction must be tailored to the individual patient. Examples of the different forms of sagittal synotsosis are discussed, and the various surgical techniques available are detailed.
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3

Haug, R. H. "Sagittal synostosis." Journal of Oral and Maxillofacial Surgery 53, no. 4 (April 1995): 489. http://dx.doi.org/10.1016/0278-2391(95)90740-8.

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4

Ocampo, Renato V., and John A. Persing. "Sagittal Synostosis." Clinics in Plastic Surgery 21, no. 4 (October 1994): 563–74. http://dx.doi.org/10.1016/s0094-1298(20)30724-0.

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5

Posnick, Jeffrey C., Kant Y. Lin, Philip Chen, and Derek Armstrong. "Sagittal Synostosis." Plastic and Reconstructive Surgery 92, no. 6 (November 1993): 1015–24. http://dx.doi.org/10.1097/00006534-199311000-00003.

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6

Posnick, Jeffrey C., Kant Y. Lin, Philip Chen, Derek Armstrong, and Charles H. Thorne. "Sagittal Synostosis." Plastic and Reconstructive Surgery 92, no. 6 (November 1993): 1025–26. http://dx.doi.org/10.1097/00006534-199311000-00004.

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7

Masand, M. "Sagittal synostosis." Case Reports 2010, oct01 1 (October 4, 2010): bcr0520103026. http://dx.doi.org/10.1136/bcr.05.2010.3026.

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8

Huang, Martin H. S., Wendy E. Mouradian, Steven R. Cohen, and Joseph S. Gruss. "The Differential Diagnosis of Abnormal Head Shapes: Separating Craniosynostosis from Positional Deformities and Normal Variants." Cleft Palate-Craniofacial Journal 35, no. 3 (May 1998): 204–11. http://dx.doi.org/10.1597/1545-1569_1998_035_0204_tddoah_2.3.co_2.

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The correct differential diagnosis of an abnormal head shape in an infant or a child is vital to the management of this common condition. Establishing the presence of craniosynostosis, which warrants surgical correction, versus non-synostotic causes of head deformity, which do not, is not always straightforward. This paper deals with three groups of abnormal head shape that may cause diagnostic confusion: the spectrum of metopic synostosis; the dolicho-cephaly of prematurity versus sagittal synostosis; and the differential diagnosis of plagiocephaly. Special emphasis has been placed on the problem of posterior plagiocephaly, in the light of recent evidence demonstrating that lambdoid synostosis has been overdiagnosed. Metopic synostosis presents as a wide spectrum of severity. Although only severe forms of the disorder are corrected surgically, all cases should be monitored for evidence of developmental problems. The dolichocephalic head shape of preterm infants is non-synostotic in origin and is managed nonsurgically. The scaphocephalic head shape resulting from sagittal synostosis requires surgical intervention for correction. Posterior plagiocephaly may be due to unilambdoid synostosis or positional molding, which have very different clinical and imaging features. True lambdoid synostosis is rare. Most cases of posterior plagiocephaly are due to positional molding, which can usually be managed nonsurgically. Regardless of the suture(s) involved, all children with confirmed craniosynostosis should be monitored for increased intracranial pressure and developmental problems.
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9

Piatt, Joseph H. "Sagittal synostosis and ossified scalp hematoma: cause or consequence?" Journal of Neurosurgery: Pediatrics 6, no. 1 (July 2010): 29–32. http://dx.doi.org/10.3171/2010.3.peds09487.

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In this paper, the author presents 2 cases of sagittal synostosis with scaphocephaly that featured ossified scalp hematomas straddling the sagittal suture in the midparietal region. These ossified lesions were originally cephalohematomas. Collection of blood under the pericranium across the midline was possible in these cases because sagittal synostosis had obliterated the sagittal suture and its dense attachment to overlying periosteum. Scaphocephaly very likely exacerbated the difficulty of the deliveries and contributed to the causation of the scalp hemorrhages. The alternative hypothesis, that ossification of a scalp hematoma immobilized the suture and caused synostosis, is not tenable for reasons that are reviewed. Sagittal synostosis in these 2 instances was not a complication of birth trauma.
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10

Mooney, Mark P., H. Wolfgang Losken, Michael I. Siegel, Janice F. Lalikos, Albert Losken, Annie M. ,. Burrows, and Tim D. Smith. "Development of a Strain of Rabbits with Congenital Simple Nonsyndromic Coronal Suture Synostosis Part II: Somatic and Craniofacial Growth Patterns." Cleft Palate-Craniofacial Journal 31, no. 1 (January 1994): 8–16. http://dx.doi.org/10.1597/1545-1569_1994_031_0008_doasor_2.3.co_2.

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In the March 1993 issue of The Cleft Palate-Craniofacial Journal we reported a female rabbit born in our laboratory with complete bilateral coronal suture (CS) synostosis. This follow-up study presents our attempts to breed the animal and establish a strain of craniosynostotic rabbits. The second part of this study presents longitudinal somatic and craniofacial growth data in offspring with coronal suture synostosis. Serial growth data from 72 animals were collected for the present study. The sample consisted of 11 animals (10 offspring and the original female) with complete nonsyndromic unilateral (plagiocephalic) or bilateral (brachycephalic) CS synostosis, 19 animals with partial CS synostosis, and 42 unaffected control litter mates. At 10 days of age, all animals had radiopaque amalgam markers placed on either side of the frontonasal, coronal, anterior lambdoidal, and sagittal sutures. Body weights and serial lateral and dorsoventral head radiographs were taken at 1.5 (10 days), 6, 12, and 18 weeks of age. All animals showed similar body weights at 1.5 weeks of age, while completely synostosed animals exhibited a slight (about 12%), but significantly (p < .001) lowered body weight by 18 weeks of age. Results revealed that by 1.5 weeks of age the completely synostosed animals already exhibited brachycephalic cranial vaults, mid-facial hypoplasia, and increased flattening of the cranial base compared to unaffected siblings. This pattern continued through 18 weeks of age, with the partially synostosed animals exhibiting Intermediate morphologies. Compensatory overgrowths were noted primarily at the sagittal and frontonasal sutures, especially for completely synostosed animals. Findings revealed that the craniosynostotic rabbits followed predictable compensatory craniofacial growth patterns and exhibited secondary deformities similar to those reported for cases of human coronal suture synostosis. Such findings support continued efforts at developing this model to help understand, In part, the etiopathogenesis of this condition in human populations.
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11

Doumit, Gaby D., Frank A. Papay, Neal Moores, and James E. Zins. "Management of Sagittal Synostosis." Journal of Craniofacial Surgery 25, no. 4 (July 2014): 1260–65. http://dx.doi.org/10.1097/scs.0b013e3182a24635.

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12

Boltshauser, E. "Sagittal synostosis ? clinical significance?" Child's Nervous System 5, no. 2 (April 1989): 53. http://dx.doi.org/10.1007/bf00571108.

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13

Posnick, Jeffrey C., Derek Armstrong, and Uldis Bite. "Metopic and Sagittal Synostosis." Plastic and Reconstructive Surgery 96, no. 2 (August 1995): 299–309. http://dx.doi.org/10.1097/00006534-199508000-00007.

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14

Posnick, Jeffrey C., Derek Armstrong, and Uldis Bite. "Metopic and Sagittal Synostosis." Plastic and Reconstructive Surgery 96, no. 2 (August 1995): 310–15. http://dx.doi.org/10.1097/00006534-199508000-00008.

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15

Jacobsen, Petra A., Devra Becker, Daniel P. Govier, Steven G. Krantz, and Alex Kane. "Ellipsoid Analysis of Calvarial Shape." Cleft Palate-Craniofacial Journal 46, no. 5 (September 2009): 487–93. http://dx.doi.org/10.1597/06-194.1.

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Purpose: The purpose of this research was to develop a novel quantitative method of describing calvarial shape by using ellipsoid geometry. The pilot application of Ellipsoid Analysis was to compare calvarial form among individuals with untreated unilateral coronal synostosis, metopic synostosis, and sagittal synostosis and normal subjects. Methods: The frontal, parietal, and occipital bones of 10 preoperative patients for each of the four study groups were bilaterally segmented into six regions using three-dimensional skull reconstructions generated by ANALYZE™ imaging software from high-resolution computed tomography scans. Points along each segment were extracted and manipulated using a MATLAB®-based program. The points were fit to the least-squares nearest ellipsoid. Relationships between the six resultant right and left frontal, parietal, and occipital ellipsoidal centroids (FR, FL, PR, PL, OR, and OL, respectively) were tested for association with a synostotic group. Results: Results from the pilot study showed meaningful differences between length ratio, angular, and centroid distance relationships among synostotic groups. The most substantial difference was exhibited in the centroid distance PL-PR between patients with sagittal synostosis and metopic synostosis. The measures most commonly significant were centroid distances FL-PR and FL-PL and the angle OR-FR-PR. Derived centroid relationships were reproducible. Conclusion: Ellipsoid Analysis may offer a more refined approach to quantitative analysis of cranial shape. Symmetric and asymmetric forms can be compared directly. Relevant shape information between traditional landmarks is characterized. These techniques may have wider applicability in quantifying craniofacial morphology with increase in both specificity and general applicability over current methods.
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16

Hong, Brian Y., Emily S. Ho, Elizabeth Zellner, John H. Phillips, and Christopher R. Forrest. "Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis." Cleft Palate-Craniofacial Journal 56, no. 7 (December 11, 2018): 944–52. http://dx.doi.org/10.1177/1055665618815400.

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Introduction: Assessment of cranial dysmorphism in sagittal synostosis is often subjective but objective measures can be applied. These include cephalic index (CI) and midsagittal vector analysis (MSVA). Objective: To assess discriminant validity, construct validity, and responsiveness of CI and MSVA measured from computed tomography (CT) in patients with sagittal synostosis. Methods: Patients with nonsyndromic isolated sagittal synostosis with complete preoperative (n = 30) and postoperative (n = 13) CT data were included. Age-matched control group (n = 24) comprised of normocephalic patients who underwent CT for reasons related to trauma. Outcome Measures: Retrospective CT evaluation of CI and MSVA was conducted and correlated with a dysmorphism numeric rating scale (D-NRS) that measured surgeon-rated severity of sagittal synostosis. Responsiveness of CI and MSVA was evaluated using dysmorphism global rating of change (D-GRC). Results: Thirty patients with sagittal synostosis were demographically similar to 24 normocephalic patients. The difference in CI and MSVA was statistically significant between normocephalic and scaphocephalic patients. Cephalic index had a good correlation with D-NRS ( r = −0.665, ρ = −0.667), but not with MSVA ( r = 0.250, ρ = 0.203). Change in CI ( r = 0.738, ρ = 0.657) was well correlated with D-GRC, but not with MSVA ( r = −0.409, ρ = −0.301). Conclusion: Cephalic index appears to quantify the severity of sagittal synostosis better than MSVA. Cephalic index also has better responsiveness than MSVA to measure a reduction in severity of disease; however, MSVA is a better descriptive craniometric measurement. Midsagittal vector analysis was able to quantify the shift in morphology in sagittal synostosis following surgical treatment.
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17

Fischer, Andrew S., William M. Weathers, Erik M. Wolfswinkel, Robert J. Bollo, Larry H. Hollier, and Edward P. Buchanan. "Ellis—van Creveld Syndrome with Sagittal Craniosynostosis." Craniomaxillofacial Trauma & Reconstruction 8, no. 2 (June 2015): 132–35. http://dx.doi.org/10.1055/s-0034-1393733.

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Ellis—van Creveld syndrome (EVC) is a rare disorder (the incidence is estimated at around 7/1,000,000) characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia, and cardiac anomalies. Sagittal synostosis is characterized by a dolichocephalic head shape resulting from premature fusion of the sagittal suture. Both are rare disorders, which have never been reported together. We present a case of EVC and sagittal synostosis. We report the clinical features of a Hispanic boy with EVC and sagittal craniosynostosis who underwent cranial vault remodeling. The presentation of this patient is gone over in detail. A never before reported case of EVC and sagittal synostosis is presented in detail.
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18

Kuang, Anna A., Tina Jenq, Ryne Didier, Lauren Moneta, Dianna Bardo, and Nathan R. Selden. "Benign Radiographic Coronal Synostosis After Sagittal Synostosis Repair." Journal of Craniofacial Surgery 24, no. 3 (May 2013): 937–40. http://dx.doi.org/10.1097/scs.0b013e31828dcf24.

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19

Whitton, Alaina, Sharon L. Hyzy, Chelsea Britt, Joseph K. Williams, Barbara D. Boyan, and Rene Olivares-Navarrete. "Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis." Journal of Neurosurgery: Pediatrics 18, no. 1 (July 2016): 83–91. http://dx.doi.org/10.3171/2015.12.peds15414.

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OBJECTIVE The aim of this study was to examine messenger RNA (mRNA) levels of bone morphogenetic protein (BMP) ligands, receptors, and soluble inhibitors in cells isolated from single-suture synostoses from fused coronal, metopic, sagittal, and lambdoid sutures. METHODS Cells were isolated from bone collected from patients undergoing craniotomies at Children's Healthcare of Atlanta. Real-time polymerase chain reaction was used to examine mRNA levels in cells isolated from fused sutures or patent sutures in comparison with levels in normal bone from the same patient. RESULTS Cells isolated from fused sutures in cases of sagittal and coronal synostosis highly expressed BMP2, while cells isolated from fused metopic or lambdoid synostosis expressed high BMP4. Noggin, a BMP inhibitor, was lower in fused sutures and had high expression in patent sutures. CONCLUSIONS These results suggest that BMPs and inhibitors play a significant role in the regulation of suture fusion as well in the maintenance of patency in the normal suture.
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20

Persing, John A. "Immediate correction of sagittal synostosis." Journal of Neurosurgery: Pediatrics 107, no. 5 (November 2007): 426. http://dx.doi.org/10.3171/ped-07/11/426.

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21

Jane, John A., Milton T. Edgerton, J. William Futrell, and Tae Sung Park. "Immediate correction of sagittal synostosis." Journal of Neurosurgery: Pediatrics 107, no. 5 (November 2007): 427–32. http://dx.doi.org/10.3171/ped-07/11/427.

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22

Olds, M. V., B. Storrs, and M. L. Walker. "Surgical treatment of sagittal synostosis." Neurosurgery 18, no. 3 (March 1986): 345???7. http://dx.doi.org/10.1097/00006123-198603000-00016.

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23

Moore, Mark H., Amanda H. Abbott, David J. Netherway, Robert Menard, and Ahmad Hanieh. "Bilambdoid and Posterior Sagittal Synostosis." Journal of Craniofacial Surgery 9, no. 5 (September 1998): 417–22. http://dx.doi.org/10.1097/00001665-199809000-00003.

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24

Tubbs, Shane R., John C. Wellons, and Jerry W. Oakes. "Sagittal synostosis in twin girls." Child's Nervous System 18, no. 9-10 (October 1, 2002): 526–27. http://dx.doi.org/10.1007/s00381-002-0635-7.

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25

Marsh, Jeffrey L., Arthur Jenny, Miroslav Galic, Selwyn Picker, and Michael W. Vannier. "Surgical Management of Sagittal Synostosis." Neurosurgery Clinics of North America 2, no. 3 (July 1991): 629–40. http://dx.doi.org/10.1016/s1042-3680(18)30724-1.

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26

Olds, Meredith V., Bruce Storrs, and Marion L. Walker. "Surgical Treatment of Sagittal Synostosis." Neurosurgery 18, no. 3 (March 1, 1986): 345–47. http://dx.doi.org/10.1227/00006123-198603000-00016.

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Abstract A technique for the correction of scaphocephaly is described. It is safe, is technically straightforward, and rapidly corrects the deformity. The results of a standardized operative procedure in 50 patients are reviewed.
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27

Jimenez, David F., and Constance M. Barone. "Endoscopic technique for sagittal synostosis." Child's Nervous System 28, no. 9 (August 8, 2012): 1333–39. http://dx.doi.org/10.1007/s00381-012-1768-y.

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28

Rangel-Castilla, Leonardo, Steven W. Hwang, Andrew Jea, William E. Whitehead, Daniel J. Curry, Thomas G. Luerssen, and Robert C. Dauser. "Development of secondary unilateral coronal suture synostosis with a sagittal suture synostosis in a nonsyndromic patient." Journal of Neurosurgery: Pediatrics 9, no. 2 (February 2012): 116–18. http://dx.doi.org/10.3171/2011.11.peds11320.

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Multiple-suture synostosis is typically associated with syndromic craniosynostosis but has been occasionally reported in large series of nonsyndromic children. The diagnosis of multiple fused sutures usually occurs at the same time, but rarely has the chronological development of a secondary suture synostosis been noted. The development of secondary bicoronal suture synostosis requiring surgical intervention has only been reported, to date, after surgical intervention and is hypothesized to arise from a disruption of inhibitory factors from the dura. The disinhibition of these factors permits the sutures to then fuse at an early stage. The authors report on a patient who developed secondary unilateral coronal synostosis after the diagnosis of an isolated sagittal synostosis. The secondary synostosis was identified at the time of the initial surgical intervention and ultimately required a second procedure of a frontoorbital advancement. The clinical appearance of this phenomenon may be subtle, and surgeons should monitor for the presence of secondary synostosis during surgery as it may require intervention. Failure to identify the secondary synostosis may necessitate another surgery or result in a poor cosmetic outcome. The authors recommend close clinical follow-up for the short term in patients with isolated sagittal synostosis.
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29

Adamo, Matthew A., and Ian F. Pollack. "A single-center experience with symptomatic postoperative calvarial growth restriction after extended strip craniectomy for sagittal craniosynostosis." Journal of Neurosurgery: Pediatrics 5, no. 1 (January 2010): 131–35. http://dx.doi.org/10.3171/2009.8.peds09227.

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Object Sagittal synostosis accounts for the most common form of craniosynostosis, occurring with an incidence of 1 in 2000–5000 live births. In most cases of single-suture, nonsyndromic sagittal synostosis, a single operation is all that is required to achieve a reasonable cosmetic result. However, there are a number of patients who may experience symptomatic postoperative calvarial growth restriction secondary to fibrosis of newly formed bone and pericranium that replace the surgically removed sagittal suture, or due to fusion of other previously open sutures leading to increased intracranial pressure, necessitating a second operation. Methods A retrospective review was conducted of all cases involving infants who had undergone an extended sagittal strip craniectomy with bilateral parietal wedge osteotomies at our institution between 1990 and 2006 for single-suture, nonsyndromic sagittal craniosynostosis. The frequency with which subsequent operations were required for cranial growth restriction was then defined. Results There were a total of 164 patients with single-suture nonsyndromic sagittal synostosis. Follow-up data were available for 143 of these patients. The average age at time of initial operation was 5.25 months, and the mean duration of follow-up was 43.85 months. There were 2 patients (1.5%) who required a second operation for symptomatic postoperative calvarial growth restriction. Conclusions Recurrence of synostosis with resultant increased intracranial pressure in cases of single-suture, nonsyndromic sagittal craniosynostosis is an uncommon event, but does occur sporadically and unpredictably. Therefore, we recommend routine neurosurgical follow up for at least 5 years, with regular ophthalmological examinations to assess for papilledema.
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30

Cetas, Justin S., Morad Nasseri, Targol Saedi, Anna A. Kuang, and Nathan R. Selden. "Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic single-suture synostosis." Journal of Neurosurgery: Pediatrics 11, no. 6 (June 2013): 661–66. http://dx.doi.org/10.3171/2013.3.peds12525.

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Object Delayed intracranial hypertension may occur after cranial vault remodeling for synostosis and may result in visual loss and developmental delay. Delayed intracranial hypertension is relatively common in children with syndromic, multisuture synostosis, but the incidence is poorly defined in children with single-suture nonsyndromic synostosis. This study evaluates the frequency of reoperation for delayed intracranial hypertension after single-suture synostosis repair. Methods Patients who had undergone cranial vault remodeling for nonsyndromic single-suture synostosis and were treated at a single tertiary pediatric hospital between July 2000 and December 2010 were analyzed for the occurrence of delayed intracranial hypertension and reoperation for cranial vault remodeling. Results Eighty-one patients with clinical follow-up of at least 3 years were analyzed from a total of 156 consecutive patients. The average patient age at the initial operation was 9.1 months. Five (6.2%) of 81 patients presented with delayed clinical and ophthalmological signs and symptoms of intracranial hypertension following initial cranial vault reconstruction, confirmed indirectly in each case by CT findings and directly by intracranial pressure monitoring. These 5 patients underwent repeat cranial vault reconstruction. Conclusions Calvarial growth restriction and intracranial hypertension occur sporadically following primary cranial vault reconstruction for single-suture nonsyndromic cranial synostosis. In this series, delayed intracranial hypertension occurred only in male patients who underwent primary repair of isolated sagittal synostoses at an age less than or equal to 5 months.
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31

Smyth, Matthew D., and Kamlesh B. Patel. "Endoscopic-assisted repair for sagittal synostosis." Neurosurgical Focus: Video 4, no. 2 (April 2021): V9. http://dx.doi.org/10.3171/2021.1.focvid2044.

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The craniofacial team at St. Louis Children's Hospital has been performing endoscopy-assisted synostosis surgery since 2006. Most infants with single-suture synostosis younger than 6 months of age are candidates. The sphinx position is used, with two incisions: one posterior to the bregma and one anterior to the lambda. The endoscope is incorporated primarily for epidural dissection and bone edge cauterization. Blood products are available but rarely needed with single suturectomies. Patients are managed on the floor after surgery and discharged to home on postoperative day 1, with helmet therapy coordinated and initiated immediately after surgery and continued until about 12 months of age. The video can be found here: https://vimeo.com/513939623
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32

Kulkarni, Abhaya V., and Ruth Donnelly. "Editorial. Neurodevelopmental outcome and sagittal synostosis." Journal of Neurosurgery: Pediatrics 23, no. 4 (April 2019): 432–33. http://dx.doi.org/10.3171/2018.9.peds18531.

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33

Pianetti, Geraldo. "Surgical treatment of premature sagittal synostosis." Arquivos de Neuro-Psiquiatria 54, no. 1 (March 1996): 156. http://dx.doi.org/10.1590/s0004-282x1996000100026.

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Pianetti, Geraldo. "Surgical treatment of premature sagittal synostosis." Arquivos de Neuro-Psiquiatria 55, no. 3A (September 1997): 403–7. http://dx.doi.org/10.1590/s0004-282x1997000300008.

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A series of 50 consecutive children with premature sagittal synostosis is reported. All were treated surgically; 43 were male, 47 were leukodermic and two are siblings. In the pre-operative examination, the head shape, skull measurements and radiologic findings were evaluated; 38 children were operated on before six months of age and 12 of them, between six and 12 months of age. The surgical technique used was a wide biparietal craniectomy. Blood transfusions were occasional, being necessary for only six (12%) children. The children were admitted at the day of surgery and discharged between the second and the third post-operative day. No local or general complications were observed and no one died. The aesthetic result was considered good. The altered skull measurements before surgery reached normalization as far as the end of the first year after the treatment. It may be concluded that wide biparietal craniectomy is a procedure of great effectiveness in the treatment of the premature fusion of the sagittal suture.
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35

Driessen, Caroline, Irene Mathijssen, and Marie-Lise van Veelen. "Update on Treatment of Sagittal Synostosis." Journal of Craniofacial Surgery 28, no. 3 (May 2017): 589–90. http://dx.doi.org/10.1097/scs.0000000000003372.

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36

Sun, James, Netanja S. ter Maaten, Daniel M. Mazzaferro, Ari M. Wes, Sanjay Naran, Scott P. Bartlett, and Jesse A. Taylor. "Spring-Mediated Cranioplasty in Sagittal Synostosis." Journal of Craniofacial Surgery 29, no. 3 (May 2018): 632–35. http://dx.doi.org/10.1097/scs.0000000000004233.

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Liu, Tian-Jia, Shui-Hua Wu, Shuang-Shi Fan, Zhao-Hui Chen, and Shuo Gu. "A New Technique for Sagittal Synostosis." Journal of Craniofacial Surgery 29, no. 8 (November 2018): 2065–69. http://dx.doi.org/10.1097/scs.0000000000004791.

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38

van de Beeten, Stephanie D. C., Irene M. J. Mathijssen, Nathalie W. Kamst, and Marie-Lise C. van Veelen. "Headache in Postoperative Isolated Sagittal Synostosis." Plastic and Reconstructive Surgery 143, no. 4 (April 2019): 798e—805e. http://dx.doi.org/10.1097/prs.0000000000005481.

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39

Gerety, Patrick A., Marten N. Basta, John P. Fischer, and Jesse A. Taylor. "Operative Management of Nonsyndromic Sagittal Synostosis." Journal of Craniofacial Surgery 26, no. 4 (June 2015): 1251–57. http://dx.doi.org/10.1097/scs.0000000000001651.

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40

Johnston, Susan A. "Calvarial Vault Remodeling for Sagittal Synostosis." AORN Journal 74, no. 5 (November 2001): 632–47. http://dx.doi.org/10.1016/s0001-2092(06)61762-6.

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41

Kaufman, Bruce A., Cheryl A. Muszynski, Anne Matthews, and Nancy Etter. "The circle of sagittal synostosis surgery." Seminars in Pediatric Neurology 11, no. 4 (December 2004): 243–48. http://dx.doi.org/10.1016/j.spen.2004.11.006.

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42

Hassler, Werner, and Josef Zentner. "Radical Osteoclastic Craniectomy in Sagittal Synostosis." Neurosurgery 27, no. 4 (October 1, 1990): 539–43. http://dx.doi.org/10.1227/00006123-199010000-00006.

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Abstract We report our experience in the surgical treatment of sagittal synostosis using radical osteoclastic craniectomy in 60 consecutive patients. After surgery in children aged 6 months or younger (Group I), reossification usually started 2 weeks postoperatively and was complete within 6 months, resulting in an optimal skull contour. In children aged 7 to 12 months (Group II), reossification was prolonged and lasted for 12 months or longer. The skull contour normalized in its biparietal width and improved in sagittal diameter, remaining, however, slightly abnormal. In children older than 12 months (Group III), the skull contour partly improved in the biparietal diameter but did not change in the sagittal direction. Reossification was incomplete with persistent pseudosutures. Enlarged frontal subarachnoid spaces were reversible or improved in all patients independent of age at the time of surgery. We encountered no complications in our series. In our opinion, radical osteoclastic craniectomy is the simplest, most efficient, and most physiologically sound method for the treatment of sagittal synostosis in patients up to 6 months of age. This procedure allows the rapidly growing brain to form its skull vault, thus providing optimal cosmetic results. In older children, osteoplastic morcellation procedures should be the treatment of choice.
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43

Mackenzie, Katarzyna A., Charles Davis, Arthur Yang, and Martin R. MacFarlane. "Evolution of Surgery for Sagittal Synostosis." Journal of Craniofacial Surgery 20, no. 1 (January 2009): 129–33. http://dx.doi.org/10.1097/scs.0b013e318190e1cf.

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44

Patel, Kamlesh B., Gwendolyn M. Hoben, Gary Skolnick, Sybill Naidoo, Matthew D. Smyth, and Albert S. Woo. "Endoscopic-Assisted Management of Sagittal Synostosis." Plastic and Reconstructive Surgery 132 (October 2013): 113–14. http://dx.doi.org/10.1097/01.prs.0000435991.03190.f9.

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45

Persad, Amit, Keith Aronyk, Wendy Beaudoin, and Vivek Mehta. "Long-term 3D CT follow-up after endoscopic sagittal craniosynostosis repair." Journal of Neurosurgery: Pediatrics 25, no. 3 (March 2020): 291–97. http://dx.doi.org/10.3171/2019.10.peds19297.

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OBJECTIVESurgical treatment of sagittal synostosis involves various surgical modalities. Long-term follow-up issues include increased intracranial pressure, secondary sutural fusion, incomplete reossification, and suboptimal cosmetic appearance. The authors’ objective in this study was to review their long-term endoscopic surgical results in children with sagittal synostosis using 3D CT.METHODSThe authors reviewed the long-term results of their first 38 patients who underwent endoscopic sagittal synostosis repair at age 16 weeks or younger. A standard vertex craniectomy with biparietal wedges was done in each case. After surgery, the children were fitted with a helmet, which they wore until 8 months of age. Patients were followed up for 5 years or longer, at which point a 3D CT scan was obtained. The authors examined data on the cranial index, area of bony defect, presence or absence of secondary sutural fusion, neosuture formation, and scalloping of the inner table of the skull.RESULTSThirty-two of 38 children met inclusion criteria. There was a small but significant recession of the cranial index after the completion of helmeting (from 0.772 after completion of helmeting to 0.755 at 5 years). Of 32 children, 14 had a bony defect area > 4 cm2. Three children had secondary sutural fusion (two unilateral coronal, one bicoronal). Ten of 32 patients had partial neosuture formation.CONCLUSIONSThe authors report their experience with 32 of their first 38 children who underwent endoscopic sagittal synostosis repair at 16 weeks of age or younger. With a minimum duration of 5 years, this is the longest clinicoradiological follow-up utilizing 3D CT to date in children with sagittal synostosis treated with endoscopic surgery. The authors report detailed measurements of bony loss, adjacent sutural fusion, and neosuture formation.
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46

Salehi, Afshin, Katherine Ott, Gary B. Skolnick, Dennis C. Nguyen, Sybill D. Naidoo, Alex A. Kane, Albert S. Woo, Kamlesh B. Patel, and Matthew D. Smyth. "Neosuture formation after endoscope-assisted craniosynostosis repair." Journal of Neurosurgery: Pediatrics 18, no. 2 (August 2016): 196–200. http://dx.doi.org/10.3171/2016.2.peds15231.

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OBJECTIVE The goal of this study was to identify the rate of neosuture formation in patients with craniosynostosis treated with endoscope-assisted strip craniectomy and investigate whether neosuture formation in sagittal craniosynostosis has an effect on postoperative calvarial shape. METHODS The authors retrospectively reviewed 166 cases of nonsyndromic craniosynostosis that underwent endoscope-assisted repair between 2006 and 2014. Preoperative and 1-year postoperative head CT scans were evaluated, and the rate of neosuture formation was calculated. Three-dimensional reconstructions of the CT data were used to measure cephalic index (CI) (ratio of head width and length) of patients with sagittal synostosis. Regression analysis was used to calculate significant differences between patients with and without neosuture accounting for age at surgery and preoperative CI. RESULTS Review of 96 patients revealed that some degree of neosuture development occurred in 23 patients (23.9%): 16 sagittal, 2 bilateral coronal, 4 unilateral coronal, and 1 lambdoid synostosis. Complete neosuture formation was seen in 14 of those 23 patients (9 of 16 sagittal, 1 of 2 bilateral coronal, 3 of 4 unilateral coronal, and 1 of 1 lambdoid). Mean pre- and postoperative CI in the complete sagittal neosuture group was 67.4% and 75.5%, respectively, and in the non-neosuture group was 69.8% and 74.4%, respectively. There was no statistically significant difference in the CI between the neosuture and fused suture groups preoperatively or 17 months postoperatively in patients with sagittal synostosis. CONCLUSIONS Neosuture development can occur after endoscope-assisted strip craniectomy and molding helmet therapy for patients with craniosynostosis. Although the authors did not detect a significant difference in calvarial shape postoperatively in the group with sagittal synostosis, the relevance of neosuture formation remains to be determined. Further studies are required to discover long-term outcomes comparing patients with and without neosuture formation.
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47

Albright, A. Leland. "Operative Normalization of Skull Shape in Sagittal Synostosis." Neurosurgery 17, no. 2 (August 1, 1985): 329–31. http://dx.doi.org/10.1227/00006123-198508000-00016.

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Abstract The skull shape of most infants with sagittal synostosis can be normalized intraoperatively by combining sagittal strip, occipital circular, and parietal wedge craniectomies. The technique is associated with minimal morbidity.
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48

Ridgway, Emily B., John Berry-Candelario, Ronald T. Grondin, Gary F. Rogers, and Mark R. Proctor. "The management of sagittal synostosis using endoscopic suturectomy and postoperative helmet therapy." Journal of Neurosurgery: Pediatrics 7, no. 6 (June 2011): 620–26. http://dx.doi.org/10.3171/2011.3.peds10418.

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Object Suturectomy as a treatment for craniosynostosis was largely replaced in the late twentieth century by more extensive, but predictable, cranial remodeling procedures. Recent technical innovations, such as using the endoscope combined with postoperative orthotic reshaping, have led to a resurgence of interest in suturectomy as a safer, less invasive method. Methods A retrospective chart review was performed for all cases of sagittal synostosis treated with endoscopic sagittal suture strip craniectomy and helmet therapy between 2004 and 2008. Data collected included gestational age, genetic evaluations and syndromic status, age at operation, duration of procedure, need for blood transfusions, length of hospital stay, preoperative and postoperative head circumference percentile and cranial index, duration of helmet use, length of follow-up, complications, and revisions. Results Fifty-six patients with isolated sagittal synostosis were treated using endoscopic suturectomy and completed helmet therapy. Mean age at time of procedure was 3.24 months. Mean operative duration was 45.32 minutes. Mean hospital stay was 1.39 days. There were 2 transfusions and no deaths. The mean length of follow-up was 2.34 years. Helmet therapy was instituted for a mean of 7.47 months. Head circumference percentile increased from 61.42% to 89.27% over 2 years of follow-up. Cranial index increased from a preoperative mean of 0.69 to 0.76 over 2 years of follow-up. Reoperations for synostosis included 1 sagittal suture refusion and 2 cases in which other sutures fused. Conclusions Sagittal synostosis can be safely treated with endoscopic suturectomy and helmet therapy. Improvements in cranial volume and shape are comparable to open procedures and are enduring.
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Burrows, Annie M., Mark P. Mooney, Timothy D. Smith, H. Wolfgang Losken, and Michael I. Siegel. "Growth of the Cranial Vault in Rabbits with Congenital Coronal Suture Synostosis." Cleft Palate-Craniofacial Journal 32, no. 3 (May 1995): 235–46. http://dx.doi.org/10.1597/1545-1569_1995_032_0235_gotcvi_2.3.co_2.

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Craniofacial growth data from craniosynostotic children have shown that suture immobilization results in predictable restrictions of cranial vault growth in a direction perpendicular to the affected suture and compensatory growth at sutures perpendicular to the affected one. This study tests these predictions by using rabbits with nonsyndromic congenital coronal suture synostosis. Data were collected from 96 rabbits divided into three groups: 42 unaffected litter mate controls, 33 partially synostosed rabbits, and 21 completely synostosed rabbits. Markers were placed bilaterally on either side of the vault sutures at 1.5 weeks of age. Serial radiographs were taken at 1.5, 6, 12, and 18 weeks of age for assessment of growth at the vault sutures and of various cranial landmarks. Results revealed that completely synostosed animals had significantly (p <.05) shorter cranial vaults, reduced growth at the coronal suture, and increased growth at the sagittal, frontal, and squamosal sutures compared with unaffected rabbits. Results also showed that the calvarial growth observed in this craniosynostotic rabbit model closely reflects predicted compensatory patterns seen in human clinical populations and that this rabbit model is valuable for understanding the pathogeneses and craniofacial growth patterns of humans with premature cranial suture synostosis.
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50

Gociman, Barbu, Jason Marengo, Jian Ying, John R. W. Kestle, and Faizi Siddiqi. "Minimally Invasive Strip Craniectomy for Sagittal Synostosis." Journal of Craniofacial Surgery 23, no. 3 (May 2012): 825–28. http://dx.doi.org/10.1097/scs.0b013e31824dbcd5.

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