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Статті в журналах з теми "S-NO-HSA"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Tsiountsioura, Melina, Gerhard Cvirn, Axel Schlagenhauf, et al. "The Antiplatelet Action of S-Nitroso Human Serum Albumin in Whole Blood." Biomedicines 10, no. 3 (2022): 649. http://dx.doi.org/10.3390/biomedicines10030649.

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Nitric oxide donors (NO-donors) have been shown to have therapeutic potential (e.g., ischemia/reperfusion injury). However, due to their release rate/antiplatelet properties, they may cause bleeding in patients. We therefore studied the antiplatelet effects of the two different NO-donors, i.e., S-NO-Human Serum Albumin (S-NO-HSA) and Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA-NONOate) in whole blood (WB) samples. WB samples were spiked with S-NO-HSA or DEA-NONOate (100 µmol/L or 200 µmol/L), and the NO release rate (nitrite/nitrate levels via HPLC) and antiplatelet e

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2

Jakubovics, Nicholas S., Steven W. Kerrigan, Angela H. Nobbs, et al. "Functions of Cell Surface-Anchored Antigen I/II Family and Hsa Polypeptides in Interactions of Streptococcus gordonii with Host Receptors." Infection and Immunity 73, no. 10 (2005): 6629–38. http://dx.doi.org/10.1128/iai.73.10.6629-6638.2005.

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ABSTRACT Streptococcus gordonii colonizes multiple sites within the human oral cavity. This colonization depends upon the initial interactions of streptococcal adhesins with host receptors. The adhesins that bind salivary agglutinin glycoprotein (gp340) and human cell surface receptors include the antigen I/II (AgI/II) family polypeptides SspA and SspB and a sialic acid-binding surface protein designated Hsa or GspB. In this study we determined the relative functions of the AgI/II polypeptides and Hsa in interactions of S. gordonii DL1 (Challis) with host receptors. For an isogenic mutant with

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3

Nakajima, G., K. Uchida, K. Hayashi, Y. Xi, K. Takasaki, and J. Ju. "Non-coding microRNA hsa-let-7g as a novel chemoresponse biomarker for S-1 in colon cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13513. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13513.

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13513 Background: MicroRNAs (miRNAs) are small non-cording RNAs (∼ 22 nucleotide) that regulate gene expression by suppressing their target mRNAs at post-transcriptional level. Previous studies from our group have identified a number of dis-regulated miRNAs due to the loss of p53 tumor suppressor in cancer cell lines. As part of the efforts to further investigate the in vivo biological significance of these miRNAs, the expression of both hsa-let-7g and hsa-miR-200c were investigated using formalin-fixed paraffin embedded (FFPE) colon cancer specimens to evaluate the potential correlation with

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4

Rogóż, Wojciech, Jadwiga Pożycka, Aleksandra Owczarzy, Karolina Kulig, and Małgorzata Maciążek-Jurczyk. "Comparison of Losartan and Furosemide Interaction with HSA and Their Influence on HSA Antioxidant Potential." Pharmaceuticals 15, no. 5 (2022): 499. http://dx.doi.org/10.3390/ph15050499.

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Serum albumin (HSA) is the most important protein in human body. Due to the antioxidant activity, HSA influences homeostasis maintenance and transport of drugs as well as other substances. It is noteworthy that ligands, such as popular drugs, modulate the antioxidant activity of HSA. The aim of this study was to analyze the influence of losartan (LOS) and furosemide (FUR) on HSA antioxidant properties as well as the interaction between these drugs and protein using calorimetric and spectroscopic methods. LOS and FUR showed the high affinity for human serum albumin, and the binding reactions be

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5

Neumayer, C., A. Fügl, J. Nanobashvili, et al. "S-NITROSO HUMAN SERUM ALBUMIN (S-NO-HSA) REDUCES ISCHEMIA/REPERFUSION INJURY OF SKELETAL MUSCLE - HISTOMORPHOMETRIC ASPECTS." Shock 12, Supplement (1999): 58–59. http://dx.doi.org/10.1097/00024382-199911001-00182.

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6

Kerrigan, Steven W., Nick S. Jakubouvics, Gerardene Meade, Howard F. Jenkinson та Dermot M. Cox. "A Novel GPIbα Binding Protein on Streptococcus Gordonii Induces Platelet Rolling at Low Shear." Blood 104, № 11 (2004): 3663. http://dx.doi.org/10.1182/blood.v104.11.3663.3663.

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Abstract Infective endocarditis is associated with considerable morbidity and mortality and oral Streptococci are the priniciple causative organism. Platelet adhesion and subsequent aggregation play a critical role in the pathogenesis and dissemination of the infective process. The mechanism by which S. gordonii interacts with and subsequently leads to platelet activation is currently unknown. Previously we described the ability of Streptococcus sanguis to induce platelet aggregation via the platelet vonWillebrand factor receptor, GPIbα, however identification of the bacterial protein involved

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7

Mahata, Shibendu, Suman Kumar Saha, Rajib Kar, Durbadal Mandal, and Nilotpal Banerjee. "A Heuristic Approach to Design Discrete Fractional Order Integrators without Using s-to-z Transform." Solid State Phenomena 261 (August 2017): 386–93. http://dx.doi.org/10.4028/www.scientific.net/ssp.261.386.

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In this paper, a heuristic optimization technique called Harmony Search Algorithm (HSA) is efficiently employed to design Infinite Impulse Response (IIR) Discrete Fractional Order Integrators (DFOIs). Unlike the methods reported in the literature, no discretization (s-to-z transform) operator is necessary to obtain the DFOIs by using the proposed approach. To investigate the design efficiency, the HSA-based DFOIs have been evaluated against the designs based on Real coded Genetic Algorithm (RGA), Particle Swarm Optimization (PSO), and Differential Evolution (DE) using different frequency respo

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8

Bahlis, Nizar J., Carolyn J. Owen, Paola Neri, et al. "A miRNA Risk Score for the Prediction of Response to Rituximab-CHOP Therapy and Survival of Patients with Diffuse Large B-Cell Lymphoma." Blood 116, no. 21 (2010): 324. http://dx.doi.org/10.1182/blood.v116.21.324.324.

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Abstract Abstract 324 Background: Diffuse large B-cell lymphoma (DLBCL) may be curable with current immuno-chemotherapy, however nearly 30% of patients fail to benefit from this therapeutic approach. Gene expression profiling studies identified lymphocyte as well as stroma-based mRNA signatures that are predictive of response to R-CHOP; however the need for optimally cryopreserved samples has limited their clinical applicability. MicroRNAs (miRNA) are highly preserved non-coding RNAs that act post-transcriptionally to regulate gene expression by binding to the 3′UTR of mRNAs. To date multiple

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9

Rungatscher, A., S. Hallström, D. Linardi, et al. "595 Cardioprotective Effects of S-Nitroso Human Serum Albumin (S-NO-HSA) during Cardioplegic Arrest and Cold Storage in a Working Heart Heterotopic Transplant Model." Journal of Heart and Lung Transplantation 30, no. 4 (2011): S199—S200. http://dx.doi.org/10.1016/j.healun.2011.01.607.

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10

Lodi, Tiziana, Barbara Neglia, and Claudia Donnini. "Secretion of Human Serum Albumin by Kluyveromyces lactis Overexpressing KlPDI1 and KlERO1." Applied and Environmental Microbiology 71, no. 8 (2005): 4359–63. http://dx.doi.org/10.1128/aem.71.8.4359-4363.2005.

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ABSTRACT The control of protein conformation during translocation through the endoplasmic reticulum is often a bottleneck for heterologous protein production. The core pathway of the oxidative folding machinery includes two conserved proteins: Pdi1p and Ero1p. We increased the dosage of the genes encoding these proteins in the yeast Kluyveromyces lactis and evaluated the secretion of heterologous proteins. KlERO1, an orthologue of Saccharomyces cerevisiae ERO1, was cloned by functional complementation of the ts phenotype of an Scero1 mutant. The expression of KlERO1 was induced by treatment of

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11

Agarwal, Rupesh, Barbara A. Bensing, Dehui Mi, et al. "Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa." Biochemical Journal 477, no. 19 (2020): 3695–707. http://dx.doi.org/10.1042/bcj20200332.

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Infective endocarditis (IE) is a cardiovascular disease often caused by bacteria of the viridans group of streptococci, which includes Streptococcus gordonii and Streptococcus sanguinis. Previous research has found that serine-rich repeat (SRR) proteins on the S. gordonii bacterial surface play a critical role in pathogenesis by facilitating bacterial attachment to sialylated glycans displayed on human platelets. Despite their important role in disease progression, there are currently no anti-adhesive drugs available on the market. Here, we performed structure-based virtual screening using an

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12

Lhiaubet-Vallet, Virginie. "Photosensitization by chiral drugs: Looking for stereodifferentiating photoprocesses in the presence of biomolecules." Pure and Applied Chemistry 77, no. 6 (2005): 995–1000. http://dx.doi.org/10.1351/pac200577060995.

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Photoreactivity of chiral carprofen (CP) and ofloxacin in the presence of two biomolecules, namely, DNA and human serum albumin (HSA), has been reported. Analysis of the photosensitization of 2'-deoxyguanosine and thymidine (Thd) by high-performance liquid chromatograpy has shown that racemic ofloxacin and levofloxacin [its (S)-stereoisomer] acts by a mixed type I/type II mechanism, while CP does not lead to significant degradation of the nucleosides. Studies on DNA relaxation have revealed formation of single-strand breaks and specific alterations of DNA bases. Ofloxacin and levofloxacin phot

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13

Hajouj, Hanin, Ali Khattib, Dana Atrahimovich, Sanaa Musa, and Soliman Khatib. "S-Nitrosylation of Paraxonase 1 (PON1) Elevates Its Hydrolytic and Antioxidant Activities." Biomolecules 12, no. 3 (2022): 414. http://dx.doi.org/10.3390/biom12030414.

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Covalent binding between nitric oxide (NO) and a protein’s free thiol group (SH) is termed protein S-nitrosylation. Protein S-nitrosylation is involved in cellular regulation mechanisms that underlie a wide range of critical functions, such as apoptosis, alteration of enzyme activities, and transcription-factor stability. Impaired protein S-nitrosylation is associated with a growing list of pathophysiological conditions, such as cardiovascular disease, multiple sclerosis, pulmonary hypertension, and sickle cell disease. The enzyme paraoxonase 1 (PON1) binds to high-density lipoprotein to provi

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14

Jimenez, Camilo, Bennett B. Chin, Richard A. Noto, et al. "Biochemical Tumor Marker Status and Its Role in Treatment Response in Patients Who Received High-Specific-Activity I-131 MIBG in Advanced Pheochromocytoma and Paraganglioma (PPGL): Results From a Pivotal Phase 2 Clinical Trial." Journal of the Endocrine Society 5, Supplement_1 (2021): A164—A165. http://dx.doi.org/10.1210/jendso/bvab048.333.

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Abstract Background: High-specific-activity iodine-131 meta-iodobenzylguanidine (HSA I-131 MIBG; AZEDRA®) has been approved for the treatment of adult and pediatric patients (pts) 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic PPGL who require systemic anticancer therapy. We have previously presented data showing improved biomarker responses in pts treated with HSA I-131 MIBG. Here we report the impact of biomarker status on the study primary endpoint and objective tumor response. Methods: Pts with iobenguane-avid PPGL who were ineligible for sur

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15

Petersen, Helen J., Ciara Keane, Howard F. Jenkinson, et al. "Human Platelets Recognize a Novel Surface Protein, PadA, on Streptococcus gordonii through a Unique Interaction Involving Fibrinogen Receptor GPIIbIIIa." Infection and Immunity 78, no. 1 (2009): 413–22. http://dx.doi.org/10.1128/iai.00664-09.

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ABSTRACT The concept of an infectious agent playing a role in cardiovascular disease is slowly gaining attention. Among several pathogens identified, the oral bacterium Streptococcus gordonii has been implicated as a plausible agent. Platelet adhesion and subsequent aggregation are critical events in the pathogenesis and dissemination of the infective process. Here we describe the identification and characterization of a novel cell wall-anchored surface protein, PadA (397 kDa), of S. gordonii DL1 that binds to the platelet fibrinogen receptor GPIIbIIIa. Wild-type S. gordonii cells induced plat

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16

Bennette, Caroline Savage, Wei-Jhih Wang, Scott David Ramsey, and Jean A. McDougall. "Trends in the geographic distribution of cancer clinical trials in the US: 2008-2015." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6515. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6515.

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6515 Background: Access to and patient enrollment in cancer clinical trials is likely strongly impacted by where trial enrollment sites are located. Our objective was to evaluate temporal trends in the geographic location of cancer clinical trials launched in the US. Methods: We obtained the recruiting location(s) of all public- and privately-funded phase II/ III cancer clinical trials launched in the US between 2008 and 2015 from the ClinicalTrials.gov database. We linked the recruiting location(s) of each trial to the relevant hospital service area (HSA), which are defined by ZIP codes as lo

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17

Olszowska, Anna, Jacek Waniewski, Andrzej Werynski, Björn Anderstam, Bengt Lindholm, and Zofia Wankowicz. "Peritoneal Transport in Peritoneal Dialysis Patients Using Glucose-Based and Amino Acid-Based Solutions." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 27, no. 5 (2007): 544–53. http://dx.doi.org/10.1177/089686080702700514.

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Objective To evaluate peritoneal transport of fluid and solutes in continuous ambulatory peritoneal dialysis (CAPD) patients using amino acid (AA)-based versus glucose-based dialysis solutions. Methods Using iodine-labeled human serum albumin (125I-HSA) as intraperitoneal volume marker, peritoneal transport was investigated in a group of 20 clinically stable patients (11 females and 9 men, age 53 ± 15 years) on CAPD for 15 – 101 months. Two paired 4-hour dwells, one with 1.36% glucose and one with 1.1% AA dialysis solution, were performed in each patient. Intraperitoneal dialysate volume, flui

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18

Ganesan, Saravanan, Hamenth Kumar Palani, Vairavan Lakshmanan, et al. "Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells." Blood 128, no. 22 (2016): 5062. http://dx.doi.org/10.1182/blood.v128.22.5062.5062.

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Abstract There are numerous reports on bone marrow micro-environment mediated drug resistance (EM-DR) in cancer. We had previously reported, that there was significant EM-DR to ATO in APL. We had also shown that the effect of cross talk between leukemic cells and stromal cells leads to increased activation of NF-kB pathway in the leukemic cells. There are very limited data available on the effect of leukemic cell interaction on the stromal cells. We undertook a study to evaluate the changes induced by leukemic cells (NB4 cell line) on the HS-5 stromal cell line. After 2 days of co-culture with

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19

Vanhie, A., D. O, D. Peterse, et al. "Plasma miRNAs as biomarkers for endometriosis." Human Reproduction 34, no. 9 (2019): 1650–60. http://dx.doi.org/10.1093/humrep/dez116.

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Abstract STUDY QUESTION Can plasma miRNAs be used for the non-invasive diagnosis of endometriosis in infertile women? SUMMARY ANSWER miRNA-based diagnostic models for endometriosis failed the test of independent validation. WHAT IS KNOWN ALREADY Circulating miRNAs have been described to be differentially expressed in patients with endometriosis compared with women without endometriosis, suggesting that they could be used for the non-invasive diagnosis of endometriosis. However, these studies have shown limited consistency or conflicting results, and no miRNA-based diagnostic test has been vali

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20

Ishima, Yu, Ulrich Kragh-Hansen, Toru Maruyama, and Masaki Otagiri. "Poly-S-Nitrosated Albumin as a Safe and Effective Multifunctional Antitumor Agent: Characterization, Biochemistry and Possible Future Therapeutic Applications." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/353892.

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Nitric oxide (NO) is a ubiquitous molecule involved in multiple cellular functions. Inappropriate production of NO may lead to disease states. To date, pharmacologically active compounds that release NO within the body, such as organic nitrates, have been used as therapeutic agents, but their efficacy is significantly limited by unwanted side effects. Therefore, novel NO donors with better pharmacological and pharmacokinetic properties are highly desirable. TheS-nitrosothiol fraction in plasma is largely composed of endogenousS-nitrosated human serum albumin (Mono-SNO-HSA), and that is why we

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21

Lobjakas, Wiljar, Jaak Nerut, Heili Kasuk, et al. "Investigation of Oxygen Reduction on Platinum Nanoparticles Deposited Onto Peat-Derived Carbon Carrier." ECS Meeting Abstracts MA2022-01, no. 35 (2022): 1498. http://dx.doi.org/10.1149/ma2022-01351498mtgabs.

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Carbon supported platinum catalysts for proton exchange membrane fuel cell (PEMFC) applications have been studied intensively in the scientific community.1,2 The catalytic activity of the catalyst depends on the characteristics of the carbon support material3 and on the Pt depositing method4,5. The aim of the study was to investigate the oxygen reduction reaction (ORR) on Pt nanoparticles deposited on peat-derived carbon. The Pt nanoparticles were deposited on the carbon support material by three different methods using NaBH4 (NBH), ethylene glycol (EG) and isopropyl alcohol (IA) as a reducing

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22

Fichelson, S., I. Vigon, I. Dusanter, et al. "In vitro transformation of murine pro-B and pre-B cells by v-mpl, a truncated form of a cytokine receptor." Journal of Immunology 154, no. 4 (1995): 1577–86. http://dx.doi.org/10.4049/jimmunol.154.4.1577.

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Abstract v-mpl is a constitutively activated, truncated form of a cytokine receptor that has been transduced in a murine retrovirus, the myeloproliferative leukemia virus (MPLV). Expression of this oncogene results in the factor-independent proliferation of myeloid, erythroid, megakaryocytic, and mast precursor cells, which retain the ability to differentiate. However, no lymphoid disease was ever reported. To determine whether MPLV could infect and transform very early B cells and their precursors (BCPs), lymphoid long-term bone marrow cultures were infected with a helper-free MPLV. Within 3

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23

Dantham, Subrahamanyam, Achal Srivastava, Sheffali Gulati, and Moganty Rajeswari. "Differentially Regulated Cell-Free MicroRNAs in the Plasma of Friedreich's Ataxia Patients and Their Association with Disease Pathology." Neuropediatrics 49, no. 01 (2017): 035–43. http://dx.doi.org/10.1055/s-0037-1607279.

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AbstractFriedreich's ataxia (FRDA) is a multisystem disease affecting the predominately nervous system, followed by muscle, heart, and pancreas. Current research focused on therapeutic interventions aimed at molecular amelioration, but there are no reliable noninvasive signatures available to understand disease pathogenesis. The present study investigates the alterations of plasma cell-free microRNAs (miRNAs) in FRDA patients and attempts to find the significance in relevance with the pathogenesis. Total RNA from the plasma of patients and healthy controls were subjected to miRNA microarray an

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24

Gounari, Maria, Stavroula Ntoufa, Charles C. Chu, et al. "Promiscuous Antigen Reactivity May Underlie Clinical Aggressiveness and Increased Risk for Richter's Syndrome in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-39/IGKV1(D)-39 B Cell Receptors." Blood 120, no. 21 (2012): 561. http://dx.doi.org/10.1182/blood.v120.21.561.561.

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Abstract Abstract 561 Mounting evidence suggests that the molecular classification of CLL into subsets with stereotyped B cell receptors (BcRs) is functionally and clinically relevant. In fact, cases of the same subset can share not only BcR sequence motifs but also biological and clinical features as well. This suggests that the functional antigen reactivity profile of the BcR can be critical in determining the clinical features and outcome even independently of IGHV gene mutational status, at least for selected subsets. A distinctive CLL stereotyped subset, known as subset #8, is defined by

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25

von Grothusen, Carolina, Caroline Frisendahl, Vijayachitra Modhukur, et al. "Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure." Human Reproduction 37, no. 4 (2022): 734–46. http://dx.doi.org/10.1093/humrep/deac019.

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Abstract STUDY QUESTION Is the composition of microRNAs (miRNAs) in uterine fluid (UF) of women with recurrent implantation failure (RIF) different from that of healthy fertile women? SUMMARY ANSWER The composition of miRNAs in UF of women with RIF is different from that of healthy fertile women and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation. WHAT IS KNOWN ALREADY It has previously been demonstrated that the miRNAs secreted from endometrial cells into the UF contribute to the achievement of endometrial receptivity. Endometrial miRNAs ar

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26

Krowiorz, Kathrin, Razan Jammal, Stephan Emmrich, et al. "The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia." Blood 126, no. 23 (2015): 1244. http://dx.doi.org/10.1182/blood.v126.23.1244.1244.

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Abstract MicroRNAs (miRNAs) are essential for maintenance and differentiation of normal hematopoietic cells and their dysregulation is strongly implicated in leukemias. In order to identify tumor suppressor miRNAs in the context of hematological malignancies, we performed two complementary miRNA expression screenings in normal hematopoiesis as well as in childhood and adult acute myeloid leukemias (AML). We reasoned that tumor suppressor miRNAs are upregulated in mature myeloid cells, as compared to normal hematopoietic stem and progenitor cells (HSPCs), and downregulated in AML. Based on this

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27

Roth, Robert I. "Hemoglobin Enhances the Binding of Bacterial Endotoxin to Human Endothelial Cells." Thrombosis and Haemostasis 76, no. 02 (1996): 258–62. http://dx.doi.org/10.1055/s-0038-1650565.

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SummaryHuman endothelial cells, when incubated with bacterial endotoxin (lipopolysaccharide, LPS), modify their surface in association with prominent production of procoagulant tissue factor (TF) activity. This deleterious biological effect of LPS has been shown previously to be enhanced approximately 10-fold by the presence of hemoglobin (Hb), a recently recognized LPS binding protein that causes disaggregation of LPS and increases the biological activity of LPS in a number of in vitro assays. The present study was performed to test the hypothesis that Hb enhances the LPS-induced procoagulant

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Barros Junior, Edson Alves de, Marisa de Cassia Registro Fonseca, Salomão Chade Assan Zatiti, Abimael Caetano do Nascimento, Luis Guilherme Rosifini Alves Rezende, and Nilton Mazzer. "Os efeitos do ultrassom na cicatrização de tendões flexores de coelhos após reparo." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (2020): 651–54. http://dx.doi.org/10.21270/archi.v9i6.5279.

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Introdução: O efeito terapêutico do ultrassom no processo cicatricial dos tendões flexores permanece controverso na literatura. Objetivo: Avaliar morfologicamente os efeitos do ultrassom terapêutico na cicatrização de tendões flexores profundos de coelhos submetidos a tenotomia e posterior tenorrafia. Métodos: 30 coelhos foram divididos em dois grupos para tratamento com ultrassom e outro apenas para tenotomia. O ultrassom foi iniciado no 1º dia após tenorrafia e mantido até o 7º dia. Foram utilizadas frequência de 3MHz, intensidade de 0.4Wcm2 (SATA), ciclo de trabalho de 20% por 06 minutos. C

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Zhang, Qing-Bin, Si-Da Ruan, Yong Wu, Jin-Hua Zhang, Jian-Guang Lu, and Jun Feng. "Extending the in vivo Half-Life of Adalimumab Fab via Sortase A-Mediated Conjugation of Adalimumab Fab with Modified Fatty Acids." Pharmaceutical Fronts 02, no. 04 (2020): e160-e167. http://dx.doi.org/10.1055/s-0041-1728817.

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AbstractAdalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated conjugation of its Fab with fatty acid (FA). In our study, adalimumab Fab analog was prepared by adding an SrtA recognition sequence (LPETGG) and His6 tag to the heavy chain C-terminal of the Fab via (G4S)3 linker. Four FA motifs with different linkers were designed and synthesized by solid-phase methodology, then conjugated with the F

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Eide, Christopher A., Stephen E. Kurtz, Andy Kaempf, et al. "Simultaneous Kinase Inhibition with Ibrutinib and BCL2 Inhibition with Venetoclax As a Therapeutic Strategy for Acute Lymphoblastic Leukemia." Blood 134, Supplement_1 (2019): 3950. http://dx.doi.org/10.1182/blood-2019-131288.

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Background: In patients with acute lymphoblastic leukemia (ALL), patient outcomes vary considerably by patient age group, specific genetic subtypes, and treatment regimen. Large-scale sequencing efforts have uncovered a spectrum of mutations and gene fusions in ALL, suggesting that combinations of agents will be required to treat these diseases effectively. Previous preclinical studies have shown efficacy of the BCL2 inhibitor venetoclax alone or in combination in ALL cells (Chonghaile et al., Can Disc 2014; Leonard et al, STM 2018), and the multi-kinase inhibitor ibrutinib (approved for patie

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Chen, Jacky, Jay Wunder, Kim Tsoi, Nalan Gokgoz, and Irene Andrulis. "168 Expanding and characterizing tumor infiltrating lymphocytes from myxofibrosarcoma and undifferentiated pleomorphic sarcoma." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A178—A179. http://dx.doi.org/10.1136/jitc-2021-sitc2021.168.

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BackgroundSarcoma is a group of rare bone and soft tissue tumors with over 50 distinct subtypes. Survival rate ranges widely due to the lack of efficacious treatments. Immunotherapy, such as adoptive cell therapy (ACT), has drawn significant interest due to its minimal toxicity. In ACT, tumor infiltrating lymphocytes (TILs) are isolated from patients, expanded, and autologously infused back. We recently observed TILs’ presence in Undifferentiated Pleomorphic Sarcoma (UPS) and Myxofibrosarcoma (MFS) tumors and found that tumor’s PD-L1 overexpression is correlated with better clinical outcome in

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Dzilic, E., M. Kreibich, D. Santer, et al. "New NO Donor S-NO-HSA improves cardioplegic solutions." Thoracic and Cardiovascular Surgeon 60, S 01 (2012). http://dx.doi.org/10.1055/s-0031-1297417.

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Kreibich, M., E. Dzilic, D. Santer, et al. "NO-donor S-NO-HSA preserves cardiac function during local and global ischemia." Thoracic and Cardiovascular Surgeon 61, S 01 (2013). http://dx.doi.org/10.1055/s-0032-1332461.

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Mejia, O. A. V., R. C. Souza, B. Meneghini, et al. "Circulating miRNA-770-5p and miRNA-30d-5p as potential biomarkers in vasoplegic syndrome after on-pump coronary artery bypass surgery – PREVENT trial." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.2144.

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Abstract Introduction Vasoplegic syndrome (VS) is one of the most common unexpected complications following cardiothoracic surgery, approaching a 25% mortality rate. No standardized methods for diagnosing VS are available. A biomarker is a valuable tool in all fields of medicine, especially in cardiovascular disease when the patient has to undergo invasive surgery as on-pump CABG. MicroRNAs (miRNAs) have been studied and employed as biomarkers for numerous diseases, however, there are no studies regarding their expression in VS. Purpose To discover a new predictor of VS by comparing the miRNA

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Liao, Xian-min, Zheng Guan, Zhen-jin Yang, et al. "Comprehensive analysis of M2 macrophage-derived exosomes facilitating osteogenic differentiation of human periodontal ligament stem cells." BMC Oral Health 22, no. 1 (2022). http://dx.doi.org/10.1186/s12903-022-02682-5.

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Abstract Background The role of periodontal ligament stem cells (PDLSCs) and macrophage polarization in periodontal tissue regeneration and bone remodeling during orthodontic tooth movement (OTM) has been well documented. Nevertheless, the interactions between macrophages and PDLSCs in OTM remain to be investigated. Consequently, the present study was proposed to explore the effect of different polarization states of macrophages on the osteogenic differentiation of PDLSCs. Methods After M0, M1 and M2 macrophage-derived exosomes (M0-exo, M1-exo and M2-exo) treatment of primary cultured human PD

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Cometta, Silvia, Nathalie Bock, Sinduja Suresh, Tim R. Dargaville, and Dietmar W. Hutmacher. "Antibacterial Albumin-Tannic Acid Coatings for Scaffold-Guided Breast Reconstruction." Frontiers in Bioengineering and Biotechnology 9 (March 31, 2021). http://dx.doi.org/10.3389/fbioe.2021.638577.

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Infection is the major cause of morbidity after breast implant surgery. Biodegradable medical-grade polycaprolactone (mPCL) scaffolds designed and rooted in evidence-based research offer a promising alternative to overcome the limitations of routinely used silicone implants for breast reconstruction. Nevertheless, as with any implant, biodegradable scaffolds are susceptible to bacterial infection too, especially as bacteria can rapidly colonize the biomaterial surface and form biofilms. Biofilm-related infections are notoriously challenging to treat and can lead to chronic infection and persis

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Guan, R., K. Zeng, Y. Q. Liu, et al. "Potential role of circulating exosome miRNAs in left ventricular remodeling of patients with ST-segment elevation myocardial infarction." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.763.

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Abstract Background Left ventricular remodeling (LVR) in patients with ST-segment elevation myocardial infarction (STEMI) may lead to poor prognosis in which circulating exosome miRNAs play a critical role. The aim of the present study is to identify specific exosome miRNAs for LVR in patients with STEMI. Method Plasma exosome miRNAs were assessed in 20 patients (90% male, mean age of 66.95±1.65 years) 3–6 months after STEMI and 24 healthy individuals (83% male, mean age of 33.2±0.93 years) by using qPCR. Of the 20 patients, 8 had post-STEMI LVR according to echocardiographic evaluation, and t

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Нерсисян, С. А. "Izoformy mikrornk miR-148a i miR-203a predpolozhitel'no igrayut rol' supressorov kolorektal'nogo raka." Вестник Российского государственного медицинского университета, no. 2022(3) (May 2022). http://dx.doi.org/10.24075/vrgmu.2022.028.

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Izoformy mikroRNK — klass korotkih nekodiruyushchih RNK, osushchestvlyayushchih regulyaciyu ekspressii genov. Izoformy mikroRNK otlichayutsya ot kanonicheskih mikroRNK neskol'kimi nukleotidami na koncah molekuly, prichem variacii s 5′-koncov mikroRNK izmenyayut mnozhestvo genov-mishenej. Cel'yu raboty bylo provesti analiz funkcional'noj aktivnosti 5′-izoform mikroRNK v tkanyah kolorektal'nogo raka. Misheni 5′-izoform mikroRNK byli predskazany s pomoshch'yu bioinformaticheskih programm miRDB i TargetScan. Poluchennye dannye o mishenyah 5′-izoform mikroRNK byli integrirovany s dannymi sekvenirov

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Ferraldeschi, Michela, Silvia Romano, Simona Giglio, et al. "Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study." Frontiers in Neurology 12 (May 5, 2021). http://dx.doi.org/10.3389/fneur.2021.657973.

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The momentum of gene therapy in Huntington's disease (HD) deserves biomarkers from easily accessible fluid. We planned a study to verify whether plasma miRNome may provide useful peripheral “reporter(s)” for the management of HD patients. We performed an exploratory microarray study of whole non-coding RNA profiles in plasma from nine patients with HD and 13 matched controls [eight healthy subjects (HS) and five psychiatric patients (PP) to minimize possible iatrogenic impact on the profile of non-coding RNAs]. We found an HD-specific signature: downregulation of hsa-miR-98 (fold change, −1.5,

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Yang, Jun, Xiaolong Yang, Joan M. Wrobel, et al. "Is there a sub-parsec-scale jet base in the nearby dwarf galaxy NGC 4395?" Monthly Notices of the Royal Astronomical Society, June 24, 2022. http://dx.doi.org/10.1093/mnras/stac1753.

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Abstract NGC 4395 is a dwarf galaxy at a distance of about 4.3 Mpc (scale: ∼0.021 pc mas−1). It hosts an intermediate-mass black hole (IMBH) with a mass between ∼104 and ∼105 solar masses. The early radio observations of NGC 4395 with the very long baseline interferometry (VLBI) network, High Sensitivity Array (HSA), at 1.4 GHz in 2005 showed that its nucleus has a sub-mJy outflow-like feature (E) extending over 15 mas. To probe the possibility of the feature E as a continuous jet with a base physically coupled with the accretion disc, we performed deep VLBI observations with the European VLBI

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Ibañez-Perez, Jone, María Díaz-Nuñez, Marc Clos-García, et al. "microRNA-based signatures obtained from endometrial fluid identify implantative endometrium." Human Reproduction, August 27, 2022. http://dx.doi.org/10.1093/humrep/deac184.

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Abstract STUDY QUESTION Is it possible to use free and extracellular vesicle-associated microRNAs (miRNAs) from human endometrial fluid (EF) samples as non-invasive biomarkers for implantative endometrium? SUMMARY ANSWER The free and extracellular vesicle-associated miRNAs can be used to detect implantative endometrium in a non-invasive manner. WHAT IS KNOWN ALREADY miRNAs and extracellular vesicles (EVs) from EF have been described as mediators of the embryo–endometrium crosstalk. Therefore, the analysis of miRNA from this fluid could become a non-invasive technique for recognizing implantati

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Almutlaq, A., X. Gonzalez, R. Odia, et al. "P-239 Embryonic quality assessment from microRNA profiling." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.229.

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Abstract Study question Does the microRNA expression profile in blastocysts change with different embryonic quality parameters? Summary answer MicroRNA expression showed significant changes when aneuploidy was present, in day-6 compared to day-5 blastocysts and with different trophectoderm (TE) morphology grades. What is known already MicroRNA (miRNA) is a gene expression regulatory mechanism used as a diagnostic marker for some conditions. Despite the great magnitude of studies investigating the miRNA role in implantation and pregnancy complications, limited work has been done to evaluate it

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Gimenez-Escamilla, I., L. Perez-Carrillo, M. Portoles, L. Martinez-Dolz, E. Tarazon, and E. Rosello-Lleti. "Golgi Apparatus fragmentation in dilated cardiomyopathy and its relationship with the alteration of vesicular transport." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.2966.

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Abstract Background The Golgi Apparatus (GA) is an important membrane-bound organelle implied in many physiological events, as trafficking, processing and sorting of newly membrane and secretory proteins and lipids. Nevertheless, these functions can be dysregulated in a diversity of pathologies due to the alteration of the GA morphology, such as cardiovascular diseases. Previously, we described in dilated cardiomyopathy (DCM) alterations in shape and size of the secretion vesicles of GA that was related to a worse functional situation. The patients had smaller, more ellipsoidal and more numero

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