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Статті в журналах з теми "RSA advisors":
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Heller, Jason E., Benjamin F. Cummings, and Jason Martin. "Distribution channel effects on advisor managed investment performance." Financial Services Review 30, no. 2 (June 30, 2022): 145–64. http://dx.doi.org/10.61190/fsr.v30i2.3479.
Анотація:
This study focuses on the effects that business models have on advisor managed portfolio per- formance by attempting to determine if advisors at Registered Investment Advisory (RIA) firms pro- duce higher net investment results compared with advisors employed at dually registered Independent Broker/Dealer (IBD) firms. Using data from one of the largest investment advisory plat- forms in the United States, we found qualified supporting evidence that advisors at RIAs outper- formed advisors at IBDs in higher-risk portfolios through the use of Turnkey Asset Management Programs and Unified Managed Accounts.
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Hall-Yannessa, Stacey L., and Scott Forrester. "Impact of Advisor Interaction on the Development of Leadership Skills in Club Sports Officers." Recreational Sports Journal 29, no. 1 (May 2005): 9–21. http://dx.doi.org/10.1123/rsj.29.1.9.
Анотація:
Club sports are an important component of a comprehensive recreational sports program. Participation in club sports and student organizations has been of particular interest to student services professionals who relate this type of involvement to increased skills development and other dimensions of personal growth. For years, club sports programs have required an advisor for each club sport. While there is a growing body of knowledge on the personal growth and development that students experience from faculty and staff academic advising, there is little, if any, empirical research examining the impact of club sports advisors on the development of club sports officers. This study attempts to identify differences in leadership-skills development of club sport officers based on the number of hours the officers spend consulting with their advisor. The researchers surveyed 94 officers using the Student Leadership Skills Inventory eight months after their leadership role had begun. Analysis of the self-reported data reveals a positive correlation between leadership-skills development, and the amount of time spent with the advisor. Suggestions for future research are made in the context of the limitations of the study.
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P. Bramnik, Robert, and Mauro M. Wolfe. "SEC targets investment adviser community." Journal of Investment Compliance 15, no. 1 (February 27, 2014): 45–47. http://dx.doi.org/10.1108/joic-01-2014-0004.
Анотація:
Purpose – To draw attention to the US Securities and Exchange Commission's (SEC) disciplinary focus on the investment adviser community Design/methodology/approach – Describes six recent enforcement cases for disclosure, custody, supervisory, procedural, and other rule violations and compliance failures; explains changes in registered investment adviser (RIA) exemptions following enactment of the Dodd-Frank Act; discusses recent SEC announcements concerning inspections and examinations of RIAs. Findings – The SEC's recent announcements and enforcement actions signal that all advisers (both registered investment advisers and exempt reporting advisers) may want to pay particular attention to their compliance programs and supervisory procedures. Originality/value – Practical advice from experienced financial services lawyers.
4
Gaspar, Raquel M., and Madalena Oliveira. "Robo Advising and Investor Profiling." FinTech 3, no. 1 (February 3, 2024): 102–15. http://dx.doi.org/10.3390/fintech3010007.
Анотація:
The rise of digital technology and artificial intelligence has led to a significant change in the way financial services are delivered. One such development is the emergence of robo advising, which is an automated investment advisory service that utilizes algorithms to provide investment advice and portfolio management to investors. Robo advisors gather information about clients’ preferences, financial situations, and future goals through questionnaires. Subsequently, they recommend ETF-based portfolios tailored to match the investor’s risk profile. However, these questionnaires often appear vague, and robo advisors seldom disclose the methodologies employed for investor profiling or asset allocation. This study aims to contribute by introducing an investor profiling method relying solely on investors’ relative risk aversion (RRA), which, in addition, allows for the determination of optimal allocations. We also show that, for the period under analysis and using the same ETF universe, our RRA portfolios consistently outperform those recommended by the Riskalyze platform, which may suffer from ultraconservadorism in terms of the proposed volatility.
5
Daar, Eric, Edwin DeJesus, Peter Ruane, Gordon Crofoot, Godson Oguchi, Catherine Creticos, Jurgen K. Rockstroh, et al. "Phase 3 Randomized, Controlled Trial of Switching to Fixed-dose Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) from Boosted Protease Inhibitor-based Regimens in Virologically Suppressed Adults: Week 48 Results." Open Forum Infectious Diseases 4, suppl_1 (2017): S735. http://dx.doi.org/10.1093/ofid/ofx180.003.
Анотація:
Abstract Background Boosted protease inhibitor regimens (bPIs) are effective and often used in HIV-infected individuals with difficulties with adherence, but they can have drug–drug interactions and GI adverse effects. Bictegravir (B), a novel, potent integrase strand transfer inhibitor with a high barrier to resistance and low potential for drug–drug interactions, was coformulated with the recommended nucleoside reverse transcriptase inhibitor backbone emtricitabine (FTC)/tenofovir alafenamide (F/TAF) and demonstrated high efficacy and tolerability in randomized studies in treatment-naïve adults. This randomized Phase 3 study assesses efficacy and safety of switching to B/F/TAF from a multi-tablet regimen containing a bPI. Methods HIV-infected adults suppressed on regimens of boosted atazanavir (ATV) or darunavir (DRV) + abacavir/lamivudine (ABC/3TC) or FTC/tenofovir disoproxil fumarate (TDF) were randomized 1:1 to continue their current bPI regimen or switch to open-label coformulated B/F/TAF (50/200/25 mg) once daily. Primary endpoint was proportion with HIV-1 RNA ≥50 copies/mL (c/mL) at W48 (FDA snapshot). Noninferiority was assessed through 95.002% confidence intervals (CI) using a margin of 4%. Secondary endpoints included proportion with HIV-1 RNA <50 c/mL and safety measures at W48. Results A total of 577 participants were randomized and treated with B/F/TAF (n = 290) or current bPI regimens (n = 287): 17% women, 26% Black, median age 48 years. Most were receiving a bPI with FTC/TDF (85%) at screening. At W48, switching to B/F/TAF was noninferior to continuing bPI with 1.7% in each group having HIV-1 RNA ≥50 c/mL (difference −0.0%; 95.002% CI −2.5% to 2.5%, P = 1.00); the proportion with HIV-1 RNA <50 c/mL was 92.1% in B/F/TAF vs. 88.9% in bPI. No participant on B/F/TAF developed resistance to study drugs. One participant on DRV/ritonavir + ABC/3TC developed a treatment-emergent L74V mutation. Incidence of grade 3 or 4 AEs was similar (B/F/TAF 4%, bPI regimens 6%). No renal discontinuations or tubulopathy cases occurred with B/F/TAF. Conclusion Adults switching to B/F/TAF from a boosted PI maintained high rates of virologic suppression without resistance. B/F/TAF was safe and well tolerated. Disclosures E. Daar, Bristol-Myers Squibb: Consultant, Consulting fee. Gilead Sciences, Inc.: Consultant, Grant Investigator and Scientific Advisor, Consulting fee and Research support. Janssen: Consultant, Grant Investigator and Scientific Advisor, Consulting fee and Research support. Merck: Consultant, Grant Investigator and Scientific Advisor, Consulting fee and Research support. Teva Pharmaceuticals: Consultant and Scientific Advisor, Consulting fee. ViiV: Consultant, Grant Investigator and Scientific Advisor, Consulting fee and Research support. E. DeJesus, Abbott Laboratories; Achillion Pharmaceuticals, Avexa, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Hoffmann LaRoche, Idenix, Janssen, Merck, Pfizer, Sangamo, Taimed, Tobira, and Vertex: Grant Investigator, Research grant. Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, and Vertex: Scientific Advisor, Consulting fee. P. Ruane, Gilead: Investigator, Scientific Advisor and Shareholder, Consulting fee and Research support. Merck: Speaker’s Bureau, Speaker honorarium. Boehringer: Investigator, Scientific Advisor and Speaker’s Bureau, Consulting fee, Research support and Speaker honorarium. Janssen: Investigator, Scientific Advisor and Speaker’s Bureau, Consulting fee, Research support and Speaker honorarium. Abbott: Investigator, Scientific Advisor and Speaker’s Bureau, Research support and Speaker honorarium. Idenix: Investigator, Research support. ViiV: Scientific Advisor and Speaker’s Bureau, Consulting fee and Speaker honorarium. BMS: Consultant, Investigator and Speaker’s Bureau, Consulting fee, Research support and Speaker honorarium. G. Crofoot, Gilead: Investigator and Scientific Advisor, Advisory honorarium and Research grant. ViiV: Investigator and Scientific Advisor, Advisory honorarium, Research grant and Research support. C. Creticos, Thera Technologies and ViiV Healthcare: Scientific Advisor, Consulting fee. Gilead sciences, Merck, and ViiV Healthcare: Investigator, Research support. Pfizer: Speaker’s Bureau, Speaker honorarium. J. K. Rockstroh, Abbvie: Consultant and Investigator, Consulting fee and Speaker honorarium. Gilead: Consultant, Investigator and Scientific Advisor, Consulting fee and Speaker honorarium. ViiV: Scientific Advisor, Consulting fee. Janssen: Investigator and Speaker at educational event, Speaker honorarium. J. M. Molina, Gilead, ViiV, Merck, Janssen, BMS and TEVA: Scientific Advisor, Speaker honorarium. Y. P. Liu, Gilead: Employee and Shareholder, Salary and Shareholder. K. Andreatta, Gilead: Employee and Shareholder, Salary and Shareholder. H. Graham, Gilead Sciences: Employee and Shareholder, Salary. A. Cheng, Gilead: Employee and Shareholder, Salary. H. Martin, Gilead Sciences: Employee, Salary. E. Quirk, Gilead: Employee and Shareholder, Salary
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Largeaud, Laetitia, Sarah Bertoli, Emilie Berard, Suzanne Tavitian, Muriel Picard, Stephanie Dufrechou, Naïs Prade, et al. "Genomics of Hyperleukocytic Acute Myeloid Leukemia." Blood 138, Supplement 1 (November 5, 2021): 1294. http://dx.doi.org/10.1182/blood-2021-147497.
Анотація:
Abstract Hyperleukocytic AML (HL-AML) is characterised by a high risk of early death and poor prognosis. We previously reported the impact of adding dexamethasone (DEX) to intensive chemotherapy in this situation (Bertoli et al, Haematologica 2018). The aim of this study was to give a comprehensive description of HL-AML at the molecular level and to investigate interactions between molecular lesions and DEX treatment. In the earlier study which included 160 patients (pts) (18 - 75 years old) with WBC > 100 x 10 9/L or > 50 x 10 9/L with leukostasis symptoms, multivariate analyses had shown that DEX treatment was significantly associated with better DFS, EFS and OS (Bertoli S, Haematologica 2018). In this pre-midostaurin registration patient cohort (2004-2015), no pt received a FLT3 inhibitor. Diagnostic samples for NGS analyses were available for 154 pts (96.3% of the initial cohort), 59 pts who received DEX with 3+7 induction chemotherapy and 95 pts who did not. The presence of FLT3-ITD was tested as described (Larochelle O, Oncotarget 2011). CEBPA screening was performed by Sanger sequencing (Pabst T, Nat Genet 2001). Extended DNA resequencing was performed using an Illumina NextSeq500 and Sureselect target enrichment system (Agilent, Santa Clara, CA), targeted on the complete coding regions of 79 genes commonly mutated in myeloid malignancies. The cytogenetic risk was favorable, intermediate or adverse in 15 (9.7%), 121 (78.6%) and 18 (11.7%) pts. A total of 616 mutations were identified with an average of 4 mutations/pt (0 to 10 mutations/pt). Only one pt with inv(16) had no mutation detected. The most frequently mutated genes were FLT3 (62%), NPM1 (53%), DNMT3A (34%), TET2 (23%), NRAS (21%), IDH2 (12%), WT1 (11%), PTPN11 (10%), RUNX1 (10%), KRAS (9%) and IDH1 (9%). Of the 71 pts (46%) with FLT3-ITD mutations, 32 (45.1%) had an allelic ratio > 0.5. Mutations in the RAS pathway were detected in 67 pts (44%), including NRAS (n=32, 21%), PTPN11 (n=15, 10%), KRAS (n=14, 9%) and NF1 (n=6, 4%). Overall, a large majority of pts had mutations in signaling genes (n=131, 85.1%). Drug-actionable mutations such as FLT3 (n=96), IDH2 (n=17), IDH1 (n=14), KIT (n=11), TP53 (n=4) or JAK2 (n=1) were detected in 113 patients (73.4%). In patients with FLT3 mutations (n=96), 12 had co-mutations in IDH1 and 12 pts had co-mutations in IDH2. The prognostic impact of the AML genomic classification (Papaemmanuil E, NEJM 2018), NPM1/FLT3-ITD/DNMT3A status, functional gene categories (Bullinger L, JCO 2017) ELN 2017 classification and individual genes was assessed. AML with inv(16)/CBFB-MYH11, CEBPA mutations, NPM1 mutations and myeloid transcription factor gene fusions or mutations were significantly and independently associated with better OS whereas the chromatin-modifying gene subset, NPM1/FLT3-ITD/DNMT3A triple mutations, ELN 2017-adverse risk and DNMT3A mutations were associated with poorer OS. NPM1/FLT3-ITD/DNMT3A triple mutations were observed in 25 pts (16%), 23 of whom died. Compared to this triple mutated subset, lower HRs were found in double mutant NPM1mut/FLT3-ITD (HR, 0.43; 95%CI: 0.19-0.97; P=0.041) or NPM1mut/DNMT3Amut (HR, 0.47; 95% CI: 0.21-1.07; P=0.074). The prognostic impact of each individual gene was assessed using the LASSO statistical method. CBFB-MYH11 (HR, 0.10; 95% CI: 0.02-0.43; P=0.002), CEBPA (HR, 0.22; 95% CI: 0.09-0.53; P=0.001), NPM1 (HR, 0.33; 95% CI: 0.19-0.58; P<0.001) and surprisingly, RUNX1 mutations (HR, 0.40; 95% CI: 0.18-0.92; P=0.030) were independently associated with better OS. DNMT3A mutations were independently predictive of poor OS (HR, 1.76; 95% CI: 1.02-3.03; P=0.043). Median DFS (13.6 months vs 66.3, P=0.002), EFS (11.3 vs 39.4, P=0.002) and OS (18.3 vs not reached, P=0.006) were significantly better in pts who received DEX. In multivariate analyses, no significant interaction between DEX and classifications or gene mutations was found, indicating that the effect of DEX did not differ significantly between the various genetic subsets. This may be due to insufficient numbers or DEX may have broader effects on biological phenomena such as inflammation. Since more than 80% of pts have mutations in signaling genes, inhibition of signaling pathways could improve prognosis of HL-AML. The impact of midostaurin will be interesting to analyse in this setting. Inhibition of the RAS pathway could also be a valuable avenue. Figure 1 Figure 1. Disclosures Bertoli: Astellas: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees; Daiichi-Sankyo: Honoraria, Membership on an entity's Board of Directors or advisory committees; Jazz Pharmaceuticals: Honoraria, Membership on an entity's Board of Directors or advisory committees; Sanofi: Honoraria, Membership on an entity's Board of Directors or advisory committees. Tavitian: Novartis: Consultancy. Vergez: Pierre Fabre Laboratory: Research Funding; Roche: Research Funding. Huguet: Novartis: Other: Advisor; Jazz Pharmaceuticals: Other: Advisor; Celgene: Other: Advisor; BMS: Other: Advisor; Amgen: Other: Advisor; Pfizer: Other: Advisor. Delabesse: Novartis: Consultancy; Astellas: Consultancy. Recher: Daiichi Sankyo: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Honoraria; Janssen: Honoraria; Jazz: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS/Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; MaatPharma: Research Funding; Macrogenics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees; Astellas: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Agios: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. OffLabel Disclosure: dexamethasone in hyperleukocytic AML.
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Nicolini, Franck E., Gabriel Etienne, Francoise Huguet, Agnès Guerci-Bresler, Aude Charbonnier, Martine Escoffre-Barbe, Viviane Dubruille, et al. "Treatment-Free Remissions in Newly Diagnosed CP CML Patients Treated with the Combination of Nilotinib + Pegylated Interferon Alpha 2a Versus Nilotinib Alone in the National Phase III Petals Trial." Blood 138, Supplement 1 (November 5, 2021): 2553. http://dx.doi.org/10.1182/blood-2021-146412.
Анотація:
Abstract Aims: Combining 2GTKI+pegylated IFN-a (Peg-IFN) represents an attractive approach for first-line treatment of CP CML, while providing somewhat light additional AEs, it induces high rates of deep molecular responses. We evaluated nilotinib (NIL) alone versus NIL+Peg-IFN in newly diagnosed CP-CML patients (pts) in a randomised phase III trial (PETALs, EudraCT 2013-004974-82) and analysed here the proportion of patients reaching Treatment-Free Remission (TFR) and outcome. Methods: Newly diagnosed CP CML pts ≤65 years, without vascular history were randomized 1:1 to get NIL 300 mg BID alone [M0 to M72 (unless TFR), arm A] vs Peg-IFN alone for 30 days (M-1→M0) 30 mg/wk, prior to NIL 300 mg BID + Peg-IFN 30 mg/wk 2 wks, upgraded to 45 mg/wk thereafter, for up to 2 y (M0 to M24, arm B) followed by NIL alone until M72 unless TFR. The primary endpoint was the rate of MR4.5 by M12, and after amendment, the trial was extended to 72 months follow-up in order to add, as a secondary endpoint, the TFR rate in pts reaching MR4.5 ≥2 y. The trigger for treatment resumption was loss of MMR. All molecular assessments were centralised until M36, and in case of TFR, MR4.5 was centrally confirmed at M0 TFR, and further molecular follow-up was then performed locally. All molecular quantifications are expressed as BCR-ABL1/ABL1 (IS) in % with ≥32,000 copies of ABL1 as control in the central lab and in the local labs all involved to the pluri-annual French external quality controls. Results are analysed in intention-to-treat. Results: As previously reported, 200 pts were randomized (99 in A, 101 in B), 130 M and 35 F in each arm, median age of 46 (18-66) y. The median follow-up (FU) since diagnosis is now 47.5 (33.77-62.39) Mo. and the median FU since discontinuation is 9.86 (5.8-23) Mo. in arm A and 15.57 (12.62-22.77) Mo. in arm B. Sokal and ELTS scores were high in 25% and 2.5%, intermediate in 33% and 16.5% and low in 42% and 81% pts respectively, equally balanced. All pts harboured a "Major" BCR transcript. We have previously shown that by M12, the rate of MR4.5 was 15.9% vs 21.5% (primary endpoint met, p=0.049) and that the overall cumulative incidence of MR4.5 was somewhat superior in arm B (54.6 [43.7-65.5] %) vs A (44 [31.5-54] %), p=0.05. Two pts died, one from myeloid blast crisis before TFR (arm A), one from a solid tumour (arm A). Overall, 40 pts (20%) reached the TFR criteria, 21 in arm A with a median FU of 9.86 (5.8-23) Mo. and 19 in arm B with a median FU since Nilo cessation of 15.57 (12.62-22.77) Mo, partly related to slightly different time for obtaining sustained MR4.5 in favour of arm B (16 vs 13 Mo.). For these 40 pts reaching TFR criteria, there was no statistical difference in terms of age at diagnosis and age at TFR, gender, Sokal, ELTS, FU since diagnosis, undetectability at cessation, BCR-ABL1 levels at 3 Mo. after cessation between the 2 arms. The survival without loss of MMR after cessation is illustrated in Figure 1. It looks superior in arm B over arm A, but did not reach statistical difference (p=0.445), but the FU is very short after cessation yet, especially in arm A. Once NIL was resumed in the pts that failed TFR, all pts recovered MMR within 6 Mo., with no difference between arms (p=1.00). In univariate analysis, we did not identify significant factor impacting on the TFR success (age at cessation, sex, undetectability at cessation, Sokal, ELTS) except the BCR-ABL1 value at M3-TFR (undetectable versus detectable, HR 7.15 [2.06-24.75], p=0.002), and the duration of MR4.5 before discontinuation (HR 1.11 [1.03-1.19], p=0.004). During this TFR phase 7 SAEs were reported in arm A (2 pregnancies, 1 obstructive sleep apnea, 1 fever episode, 1 carotid stenosis and 1 femoral stenosis in the same patient at 2 Mo. after cessation, 1 lung carcinoid tumor) and 2 in arm B (1 persistent atrial fibrillation, 1 cholecystectomy). Conclusions: The combination of NIL + Peg-IFN induces higher MR4.5 rates by M36 in newly diagnosed CP CML pts that may translate in higher successful TFR rates, however a longer follow-up is needed to see consistent significant differences. Updated data will be presented. Figure 1 Figure 1. Disclosures Nicolini: Kartos Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: travel, accommodations, expenses, Research Funding; Incyte Biosciences: Honoraria, Other: travel, accommodations, expenses, Research Funding, Speakers Bureau; Sun Pharma Ltd.: Consultancy, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria. Etienne: Incyte: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau. Huguet: Novartis: Other: Advisor; Jazz Pharmaceuticals: Other: Advisor; Celgene: Other: Advisor; BMS: Other: Advisor; Amgen: Other: Advisor; Pfizer: Other: Advisor. Guerci-Bresler: Novartis: Speakers Bureau; Incyte: Speakers Bureau. Charbonnier: Incyte: Speakers Bureau; Novartis: Speakers Bureau. Rousselot: Incyte, Pfizer: Consultancy, Research Funding. Deconinck: Stemline Therapetutics: Membership on an entity's Board of Directors or advisory committees; Imunogen: Membership on an entity's Board of Directors or advisory committees; Chugai: Research Funding; Novartis: Research Funding; Pfizer: Other: Travel Grants, Research Funding; Abbevie: Research Funding. Rea: Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees.
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Adamia, Sophia, Zuzana Chyra, Morgan O'Keefe, Shruti Bhatt, Kenneth Wen, Geoffrey G. Fell, Yu-Tzu Tai, et al. "Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma." Blood 138, Supplement 1 (November 5, 2021): 2688. http://dx.doi.org/10.1182/blood-2021-152986.
Анотація:
Abstract Background: RAS/CDK-dependent pathways play essential roles in multiple myeloma (MM) pathogenesis. Targeting these pathways represents a novel therapeutic strategy in MM. Our ongoing studies (>420 patients) demonstrate that aberrantly spliced transcript expressions can predict MM patient survival outcomes better than gene expression alone, indicating a significant role of splicing mechanism in MM pathophysiology. These studies also identified intron retentions as the predominant recurrent alterations (~32% of spliced genes were retained introns) in MM. We evaluated splicing alterations associated with pathway-level responses after RAS/CDK inhibition in order to identify and validate novel molecular targets. Methods/results: MM cells were treated with selected Erk1/2 and CDK4/6 inhibitors (Ei, Ci) to inhibit RAS and CDK pathways. Our studies demonstrated strong synergistic (IC<0.5) MM cytotoxicity triggered by this combination treatment, which triggered dose-dependent manner G0/G1 phase growth arrest. We assessed early death cascade in MM cells after Ei+Ci treatment, and demonstrated significant priming to selective peptides BIM, BAD, and MS1 or HRK, suggesting dependency on BCL2 and MCL1 or on BCL-XL proteins. Our studies showed that Ei+Ci treatment induced inhibition of key target molecules in Erk1/2 and CDK4/6 signaling including c-myc, p-RSK, p-S6, p-RB, and E2F1, suggesting on-target activity of Ei and Ci. Patient MM cells co-cultured with or without autologous BM stromal cells remain equally sensitive to Ei+Ci, suggesting that this combination can overcome the protective effects of the MM BM milieu. Moreover, our in vivo study demonstrated a significant (P=0.0004) MM burden decrease in Ei+Ci-treated mice. We evaluated the effect of Ei+Ci treatment on target gene expression in BM cells isolated from flushed femurs of treated animals with Ei, Ci or Ei+Ci, and observed downregulation of Erk1/2-CDK4/6-dependent gene signature. Therefore, we suggest that these inhibitors selectively target Erk1/2, CDK4/6 and their downstream substrates both in vitro/vivo. We next evaluated aberrantly spliced transcript expression in MM cells, with/without Erk1/2 knockdown (KD) or with Ei+Ci treatment. Unsupervised clustering of deregulated genes showed dose-dependent treatment effects. This observation was further supported by principal component analyses: upregulation in response to Erk1/2 KD and downregulation due to treatment with Ei+Ci were considered spliced gene-signatures linked to RAS/CDK modulation. Gene/pathway enrichment analyses of these genes showed their involvement in cell proliferation and regulation of epigenetic networks in MM. Importantly, these analyses suggest that overexpression of RAVER1/SNRPB core splicing regulator genes are associated with RAS/CDK pathway regulation. These genes encode subunits of U1/2/4/5 spliceosome complex and are involved in intron retention processes, a marker of malignant transformation. We compared signature-gene expressions from 558 MM patient samples to the signature-genes in plasma cells from normal donors and observed significant (p<2e-11) upregulation of genes with progression from MGUS to sMM, and, also to overt MM . SNRPB overexpression is associated with shorter overall patient survival (p<0.01), while RAVER1 is linked with poor outcomes. SNRPB proteins are also overexpressed in MM cells. Our studies evaluating SNRPB effects on RNA splicing showed both upregulation of transcripts with full intron retention and transcripts with cryptic stop codons utilizing intronic sequences causing their partial retention. We evaluated RAVER1 and SNRPB expression in BM cells from animals treated with Ei and Ci alone or in combination. We observed significant downregulation of RAVER1/SNRPB (p=0.001) in BM samples obtained from animals treated with Ei+Ci. We observed decreased intron retention events in genes in treated samples, consistent with our in vitro analyses in MM cell lines and patient samples. Thus, RAVER1/SNRPB overexpression contributes to the aberrant transcriptome splicing associated with RAS/CDK cascade in MM. Conclusions: Our studies 1) show an association between RNA processing and RAS-CDK pathways in MM, 2) identify a core splicing protein, SNRPB/RAVER1, as a novel target for modulating this cascade, and 3) suggest that targeting spliceosome complexes represents a promising therapy in MM. Disclosures Letai: Zentalis Pharmaceuticals: Other: equity holding member of the scientific advisory board; Dialectic Therapeutics: Other: equity holding member of the scientific advisory board; Flash Therapeutics: Other: equity holding member of the scientific advisory board. Anderson: Bristol Myers Squibb: Membership on an entity's Board of Directors or advisory committees; Millenium-Takeda: Membership on an entity's Board of Directors or advisory committees; Gilead: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Sanofi-Aventis: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Scientific Founder of Oncopep and C4 Therapeutics: Current equity holder in publicly-traded company, Current holder of individual stocks in a privately-held company; AstraZeneca: Membership on an entity's Board of Directors or advisory committees; Mana Therapeutics: Membership on an entity's Board of Directors or advisory committees.
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Wexler, Mark N., and Judy Oberlander. "Robo-advisors (RAs): the programmed self-service market for professional advice." Journal of Service Theory and Practice 31, no. 3 (January 8, 2021): 351–65. http://dx.doi.org/10.1108/jstp-07-2020-0153.
Анотація:
PurposeThis conceptual paper draws together an interdisciplinary approach to robo-advisors (RAs) as an example of an early and successful example of automated, programmed professional services.Design/methodology/approachLittle is known about the forces driving this change in the delivery of professional service. This work explores the drivers of RAs, the degree of disruption incurred by the introduction of RAs, and how, as RAs advance, trust in algorithmic authority aids in legitimating RAs as smart information.FindingsFrom the firms' perspective, the drivers include rebranding occasioned by the financial crisis (2008), the widening of the client base and the “on-trend” nature of algorithmic authority guided by artificial intelligence (AI) embedded in RAs. This examination of the drivers of RAs indicates that professional service automation is aligned with information society trends and is likely to expand.Practical implicationsExamining RAs as an indicator of the future introduction of programmed professional services suggests that success increases when the algorithmic authority in the programmed serves are minimally disruptive, trustworthy and expand the client base while keeping the knowledge domain of the profession under control of the industry.Originality/valueTreating RAs as an early instance of successfully embedding knowledge in AI and algorithmically based platforms adds to the early stages of theory and practice in the monetization and automation of professional knowledge-based services.
10
Carande, Robert. "Reference Advisory Systems (RAS): Some Practical Issues." Reference Services Review 17, no. 3 (March 1989): 87–90. http://dx.doi.org/10.1108/eb049069.
Дисертації з теми "RSA advisors":
1
Gohin, Audrey. "Variabilité des pratiques professionnelles des conseillers/référents RSA. Le rôle de la représentation de l'employabilité, du sentiment de reconnaissance et des conflits de rôles et de valeurs perçus." Electronic Thesis or Diss., Toulouse 2, 2023. http://www.theses.fr/2023TOU20066.
Анотація:
Depuis la sortie des Trente Glorieuses, les politiques de l’emploi et de lutte contre l’exclusion s’efforcent de résorber le chômage de masse (Zoberman, 2011). Aux échelles nationale et départementale, les dispositifs d’aide à l’insertion se multiplient et se succèdent. Cette diversité rend peu lisible le « maquis institutionnel » qui caractérise le secteur de l’insertion professionnelle (DARES, 2008) malgré une volonté gouvernementale de réduire ce millefeuille par la voie de « France Travail » (2023). Si nombre de travaux scientifiques se sont centrés sur la construction (Ebersold, 2005 ; Trindade-Chadeau, 2012) et sur les effets de ces dispositifs sur les demandeurs d’emploi (Hamzaoui, 2005 ; Wuhl, 1996), peu de travaux se sont intéressés aux acteurs du secteur de l’insertion qui œuvrent en bout de chaîne des politiques de l’emploi. Partant de ce constat, notre thèse, ancrée en psychologie sociale du travail et des organisations, vise à analyser la variabilité des pratiques professionnelles d’une population spécifique d’acteurs de l’insertion : « les conseillers/référents du Revenu de Solidarité Active (RSA) ». Le champ professionnel de l’insertion a la particularité de se situer à la croisée de logiques gestionnaires qui visent à réduire le nombre de demandeurs d’emploi (Bajoit, 2005 ; Zwick Monney, 2015b) et de valeurs plus humanistes héritées du secteur du social, plus à même de tenir compte de la singularité des situations des demandeurs d’emploi (Brégéon, 2008). Dans ce contexte particulier, comment les conseillers/référents RSA exercent-ils et se représentent-ils leur rôle professionnel ? Certains conseillers RSA vont, par exemple, davantage adapter leur pratique aux prescriptions institutionnelles en matière d’employabilité. D’autres vont davantage chercher à se dégager une marge de manœuvre afin de tenir compte de la spécificité des situations des personnes accompagnées. Inscrite dans une perspective psychosociale, la thèse vise à décrire et à rendre compte de la variabilité des pratiques professionnelles à travers l’orientation de rôle des conseillers/référents RSA. En référence au modèle théorique d’une socialisation plurielle et active (Baubion-Broye et al., 2013 ; Malrieu, 1989), nous postulons que l’orientation du rôle professionnel de ces conseillers/référents ne dépend pas de façon linéaire des prescriptions institutionnelles mais qu’il relève d’une activité subjective complexe – d’intersignification - mettant en perspective leurs représentations professionnelles - de l’employabilité et du cadre institutionnel prescrit -, leur rapport à soi et aux autres (sentiment de reconnaissance) et leurs propres valeurs qui peuvent être parfois cohérentes entre elles ou parfois concurrentes et source de conflits intrapersonnels. Cette activité – non exempte de doutes, de remises en question – génère une orientation du rôle spécifique à chaque conseiller. Pour rendre compte de cette variabilité, nous avons utilisé une méthodologie mixte qui articule deux volets empiriques : une étude qualitative exploratoire et une étude extensive. L’étude qualitative a été menée par entretiens semi-directifs auprès de 12 référents RSA. Une double analyse des entretiens – thématique et lexicométrique via AlcesteEducation2018 - montre deux orientations du rôle professionnel prédominantes chez les référents RSA. L’étude extensive menée par questionnaire auprès de 211 conseillers/référents RSA nous a permis de montrer que les conseillers/référents RSA s’inscrivent soit dans une dynamique conflictuelle dans l’orientation de leur rôle professionnel, soit dans une dynamique de reconnaissance de l’orientation de ce rôle. Les deux volets empiriques montrent une population majoritairement à l’aise dans l’orientation de son rôle professionnel mais qui développe toutefois des inquiétudes pour l’avenir de son secteurSince the end of « the 30-year post-war boom », the french employment and fight against exclusion policies have been trying to reduce the mass employment (Zoberman, 2011). At national and local levels, job integration plans are happening with greater frequency. However, this diversity make understandable the « insititutional confusing » typical for french job integration system (DARES, 2008) despite the government's desire to reduce this maze through « France Travail » (2023). While a number of academic studies have focused on buildings plans (Ebersold, 2005 ; Trindade-Chadeau) and evaluate the effects of theses plans on job-seekers (Hamzaoui, 2005 ; Wuhl, 1996), few studies have examined the actors in the integration sector, at the end of the employment policy chain. Based on this observation, our thesis, rooted in Work and Organizations Psychology, aims to analyze the professional practice of a specific population of insertion actors : "Revenu de Solidarité Active (RSA) advisors/referents". The french integration system is unique, it is at the crossroads between managerial logics aimed at reducing the number of jobseekers (Bajoit, 2005 ; Zwick Monney, 2015b) and more humanistic values herited from the social sector, which are better to take account of the singularity of jobseekers situations (Brégéon, 2008). In this particular context, how do RSA advisors/referents exercise and represente their professional role? Some RSA advisors/referents, for example, are more likely to adapt their practices to institutional prescriptions on employability. Others are more likely to seek a certain flexibility to take account of the specific situations of the people they support. Inscribed in a psychosocial perspective, the thesis aims to describe and account for the variability of guidance practices through the role orientation of RSA advisors/referents. With reference to the theoretical model of plural and active socialization (Baubion-Broye and al., 2013 ; Malrieu, 1989),we postulate hat the orientation of the professional role of these advisors/referents does not depend in a linear way based on institutional prescriptions, but is the result of a complex subjective activity - of intersignification - putting into perspective values, representations of self, others and work, which can sometimes be coherent with each other, or sometimes competing and a source of intrapersonal conflicts. This activity - not free from doubts and questioning - gives rise to a role orientation specific to each advisor. To account for this variability, we have developed a mixed methodology that articulates two empirical strands : an exploratory qualitative study and an extensive study. The qualitative exploratory study consists of semi-structured interviews with 12 RSA referents. A double analysis of the interviews - thematic and lexicometric via AlcesteEducation2018 - shows two predominant professional role orientations among RSA referents. An extensive questionnaire survey of 211 RSA advisors/referents showed that RSA advisors/referents are either involved in a conflictual dynamic in the orientation of their professional role, or in a dynamic of recognition of the orientation of this role. Both studies show a population that is mostly comfortable in their orientation in its professional role but that develops concerns for the future of its sector
2
Silva, Juliano Pedro da. "Uma an?lise explorat?ria sobre o (a) conselheiro (a) municipal de sa?de dos conselhos da Regi?o de Sa?de de Diamantina-MG." UFVJM, 2017. http://acervo.ufvjm.edu.br/jspui/handle/1/1613.
Анотація:
Na Folha de Aprova??o consta o t?tulo: "Conselheiro municipal de sa?de, necessidade para a efetiva??o do Controle Social no SUS: an?lise da Regi?o de Sa?de de Diamantina".Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-03-26T13:17:57Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) juliano_pedro_silva.pdf: 5905952 bytes, checksum: 4787696694520b924bd7cf66d18d0c7e (MD5)
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A Participa??o Popular/Controle Social ? um princ?pio estrat?gico e estruturante do Sistema ?nico de Sa?de (SUS), garantido na Constitui??o Federal de 1988 e reafirmado com os resultados da 8? Confer?ncia Nacional de Sa?de, com a publica??o da Lei Federal n? 8.142 de 1990. Este trabalho teve como objetivo principal compreender se os conhecimentos culturais e sociais, bem como o tempo de atua??o do conselheiro de sa?de definem a sua efetividade deliberativa no Controle Social do SUS. Para o desenvolvimento da pesquisa foi realizado um contato pr?vio com os munic?pios selecionados, foram realizadas visitas programadas e agendadas nos munic?pios selecionados para aplica??o de um question?rio semiestruturado aos conselheiros(as) indicados pelo Conselho Municipal de Sa?de; o question?rio com perguntas abertas e fechadas foi respondido por escrito em local indicado pelo participante; foram realizadas tamb?m pesquisas bibliogr?ficas, que se somaram ao conhecimento pr?prio do pesquisador sobre o tema ?Participa??o Popular e Controle Social no SUS?; ap?s a coleta, os dados foram analisados, sistematizados e classificados. Foram abrangidos os Conselhos Municipais de Sa?de da Regi?o Ampliada de Sa?de do Jequitinhonha, que ? composta por 15 munic?pios. No transcurso deste trabalho foi abordado um breve hist?rico da sa?de p?blica no Brasil, no qual descrevemos a participa??o popular e o controle social na sa?de; relatamos sobre a Regi?o de Sa?de de Diamantina; apresentamos nossas an?lises e discuss?es contemplando: a estrutura e funcionamento do conselho; as a??es e atribui??es do conselho de sa?de; a identifica??o e perfil do conselheiro de sa?de; e concluindo com as considera??es finais. Foi poss?vel identificar o perfil dos conselheiros de sa?de, analisar os conselhos de sa?de e atribuir a atua??o dos conselheiros de sa?de frente ?s pol?ticas p?blicas de sa?de do SUS. Tratamos das a??es e atribui??es do conselheiro de sa?de, como agente pol?tico de relev?ncia p?blica, suas compet?ncias para deliberar sobre quest?es de sa?de p?blica e a necessidade de um processo de melhor forma??o do conselheiro de sa?de.
Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ensino em Sa?de, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017.
Popular participation/Social Control is a strategic and structuring principle of the unified health system (SUS), guaranteed in the Federal Constitution of 1988 and reaffirmed with the results of the 8th National Conference on health, with the publication of the Federal Law No. 8,142 of 1990. This work aimed to understand whether the main cultural and social skills, as well as the time of operation of the Counsellor of health define your effectiveness deliberative in Social control of the SUS. For the development of the survey was carried out a previous contact with the municipalities selected, planned and scheduled visits were carried out in the municipalities selected for implementation of a semi-structured questionnaire to directors (the) appointed by the Council Municipal health; the questionnaire with open and closed questions was answered in writing in the location indicated by the participant; also were carried out bibliographic research, which amounted to the attention of the researcher on the topic "Participation and Social control in the SUS"; after collection, the data were analyzed, systematized and classified . Were covered the municipal health Councils in the region Expanded the Jequitinhonha, which consists of 15 municipalities. In the course of this work was covered a brief history of public health in Brazil, in which we describe popular participation and social control in health; report on the health of Diamantina; We present our analysis and discussions contemplating: the structure and functioning of the Council; the actions and responsibilities of the Board of health; the identification and health advisor profile; and concluding with the final considerations. It was possible to identify the profile of the health advisors, analyzing the health boards and assign the actions of health counselors face the public health policies of the SUS. We treat the actions and responsibilities of the health counselor, as political agent of public relevance, their competence to deliberate on public health issues and the need for a process of better training of Health Advisor.
3
Pereira, Patrícia Alexandra Justino. "The corporate social responsability: focusing on consulting/advisory, banking and retail business sectors." Master's thesis, 2019. http://hdl.handle.net/10071/20956.
Анотація:
The Corporate Social Responsibility (CSR) theme has increasingly debated, reaching greater relevance in the society in which we are living. This thematic is frequently present in the policies and decisions of managers in the organizations they are leading, namely in the three main dimensions, economic, social, and environmental, due to the change and demands that society imposes.
However, there is still a devaluation of workers' opinions regarding the implementation of CSR policies by managers who oversee decision making. In that way, this study was based on a literature review to understand the critics’ opinions of this theme. Then, a survey was applied to workers who currently are working in consulting companies, in the banking area, or retail companies, and the data was submitted to quantitative treatment. The focal objective of this survey was to understand the importance that workers give to the practice of CSR policies and what impact these actions would have on the organization by employees’ perspective.
The results indicated that the employees, regardless of the industry which they are working for, considered that the implementation of good CSR policies is an added value for the employee if they are consistent with his needs.
Regarding questions related to the impact of these practices would have on the organization, all respondents agree that the implementation of these policies can meet the needs of workers and maximize the reputation of the organization. Still, around 91% of the respondents acknowledge that good CSR practices could improve companies' financial performance and profitability by providing quality goods and services.O tema da Responsabilidade Social Corporativa (RSC) é cada vez mais debatido, ganhando maior relevância na sociedade em que vivemos. Esta temática está progressivamente mais presente nas políticas e decisões dos gestores, nomeadamente nas três principais dimensões, económica, social e ambiental, devido à mudança e exigências que a sociedade impõe. Contudo, verifica-se ainda a desvalorização da opinião dos trabalhadores em relação à implementação de políticas de RSC por parte dos gestores. Neste sentido, este estudo teve por base uma revisão da literatura de modo a ser percebida a opinião dos críticos desta temática. De seguida, foi aplicado um questionário a trabalhadores que atualmente desempenham funções em empresas de Consultoria, na área da Banca ou que trabalham em empresas de Retalho, cujos dados foram submetidos a um tratamento quantitativo. O principal objetivo deste inquérito foi perceber a importância que os trabalhadores dão à prática de políticas de RSC e qual seria o impacto que estas ações teriam na organização, na perspectiva dos colaboradores. Os resultados indicaram que os trabalhadores, independentemente do ramo de atividade, consideraram que a implementação de boas políticas de RSC são uma mais-valia para o próprio, caso estas sejam coerentes com as suas necessidades. De acordo com as questões relativas ao impacto que estas práticas teriam na organização, a totalidade dos inqueridos concorda que a implementação destas políticas podem satisfazer as suas necessidades e maximizar a reputação da organização, e ainda cerca de 91% dos inquiridos reconhece que boas práticas podem melhorar o desempenho financeiro e a lucratividade das empresas, fornecendo bens e serviços de qualidade.
Книги з теми "RSA advisors":
1
AdvisorBenchmarking, Inc. The changing face of RIA firms: A comprehensive analysis of the RIA marketplace, 1999-2002. 2nd ed. Rockville, MD: AdvisorBenchmarking, 2003.
2
Samet, Jonathan M. Clean Air Scientific Advisory Committee's (CASAC) review of EPA's Risk and Exposure Assessment (REA) to support the review of the SO₂ Primary National Ambient Air Quality Standard: Second draft. Washington, D.C: U. S. Environmental Protection Agency, Office of the Administrator, Science Advisory Board, 2009.
3
Regional Programme for Industrial Automation of the Capital Goods Sector in Latin America (1st 1991 Caracas, Venezuela). Programme on inudstrial automation of the capital goods industry of Latin America US/RLA/90/004: Final report of the Official Opening Meeting, First Meeting Regional Technical Secretariat (SETERE) and First MeetingExternal Advisory Group (GAEX), Caracas, Venezuela, 15-18 July 1991. [Vienna, Austria]: United Nations Industrial Development Organization, Industrial Institutions and Services Division, 1992.
4
Carande, Robert. Reference advisory systems (RAS): Some practical issues. 1989.
5
Orr, Cynthia. Crash Course in Readers' Advisory. ABC-CLIO, LLC, 2014. http://dx.doi.org/10.5040/9798400633041.
Анотація:
One of the key services librarians provide is helping readers find books they'll enjoy. This "crash course" will furnish you with the basic, practical information you need to excel at readers' advisory (RA) for adults and teens. The question "can you recommend a good book?" can be one of the most daunting you face, notwithstanding the fact that recommender tools are ubiquitous. Often, uncertainty arises because, although librarians are called on to perform such services daily, readers' advisory is a skill set in which most have no formal training. This guide will remedy that. It is built around understanding books, reading, and readers and will quickly show you how to identify reading preferences and advise patrons effectively. You'll learn about multiple RA approaches, such as genre, appeal features, and reading interests and about essential tools that can help with RA. Plus, you'll discover tips to help you keep up with this ever-changing field. There is no other professional book that covers the full spectrum of skills needed to perform the RA service that is in such great demand in libraries of all kinds. Helping readers find what they want is a sure way to serve patrons and build your library's brand. You will come away from this easy-to-understand crash course with the solid background you need to do both.
6
Greenfield, Cynthia, and Greg Friedman. Integrating Culture in Successful RIA Mergers and Acquisitions: The Guide for Financial Advisors. Springer International Publishing AG, 2021.
7
Greenfield, Cynthia, and Greg Friedman. Integrating Culture in Successful RIA Mergers and Acquisitions: The Guide for Financial Advisors. Springer International Publishing AG, 2022.
8
Programme on industrial automation of the capital goods industry of Latin America, US/RLA/90/004: Final report of the official opening meeting, first meeting, Regional Technical Secretariat (SETERE) and first meeting, External Advisory Group (GAEX), Caracas, Venezuela, 15-18 July 1991. [S.l]: United Nations Industrial Development Organization, Industrial Planning Branch, Industrial Institutions and Services Division, 1992.
Частини книг з теми "RSA advisors":
1
Jangir, Kshitiz, Vikas Sharma, Munish Gupta, Priya Grover, and Sanjay Taneja. "Efficiency Boost and Adoption." In Robo-Advisors in Management, 90–103. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-2849-1.ch006.
Анотація:
Robotic Process Automation is in its nascent stages, where it is still being explored for various business purposes and the functions for which it can be utilized. With the same effect on various processes as that of technology, RPA tends to decrease the monotonous, repetitive work, time, and cost and increase the efficiency by which an organization can work. This study aims to explore the effect of RPA in accounting. The study uses a technology adoption model to determine the factors that play an important role in adopting of robotic process automation in accounting fielding by professional accountants. The study also introduced one new dimension for the adoption of TAM, i.e., the increase in efficiency. The analysis of data was done through PLS-SEM (structural equation modelling). The results show that all the hypotheses were supported. The study could be helpful for managers, organizations, and individuals inthe adoption of technologies in processes like accounting.
2
Svensjo, Tor, Feng Yao, Bohdan Pomahac, and Elof Eriksson. "Gene therapy applications of growth factors." In Growth Factors and Receptors, 227–52. Oxford University PressOxford, 1998. http://dx.doi.org/10.1093/oso/9780199636471.003.0010.
Анотація:
Abstract Gene therapy (GTh) involves transfer of DNA to somatic cells with the purpose of getting those cells to express certain proteins or antisense RNA. Currently all protocols for GTh are experimental, but with the ultimate goal of curing patients. Remarkable progress has marked the field of GTh in the past decade. Since the first Recombinant DNA Advisory Committee (RAC) approved treatment that employed gene transfer (GTr) to study and treat human disease (1) the number of clinical trials involving GTh has increased exponentially, and as of March 1996 there were 145 approved human GTh protocols in the USA (2). Diseases that have been targeted include several congenital disorders (e.g. adenosine deaminase (ADA) deficiency, cystic fibrosis, and familial hypercholesterolaemia) and acquired immunodeficiency syndrome (AIDS), but more commonly the therapies are targeted at cancer (3).
3
Roz Faraco, Carmen Cecilia, and Nazaret Martínez-Heredia. "Formation of Practical Experience With Teachers of Physical Education in the Room of Psychomotricity in Childish Education." In Advances in Early Childhood and K-12 Education, 167–86. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-7585-7.ch010.
Анотація:
The main objective of this research is the design of a training program for teachers of education physics in the institution of psychomotor circuits within the psychomotor room in the Educational Center Santa Rosa School (Venezuela) using a methodology based on participatory action research capable of handling the most elementary and obvious didactic situations determined and delimited by the actors themselves based on the implementation of the cycle model—reflection-practice-observation-execution—which transforms the teachers in protagonist and integrates the figure of the educational advisor in the process of formation. The results show the change from a poorly supported pedagogical practice to an enriched one where the creation of a method of systematization of information stands out, which made his work more effective due to the creation of a series of formats for evaluation and observation relevant to the population and its performance.
4
Hoock, Holger. "A Year In The Life Of Joseph Farington, R.A." In The King’s Artists, 225–34. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199266265.003.0010.
Анотація:
Abstract The year 1798 was a tremendously busy one for landscape painter Joseph Farington. His painting practice and active social life apart, he was central to many Academy projects. Though he did not hold any office, as a natural and astute administrator and chief adviser to President West, Farington pulled the strings behind the scenes at Somerset House. The year started with celebrations: Farington, West, and Robert Smirke had successfully lobbied Parliament to grant Academicians an exemption from Pitt’s dramatic trebling of assessed taxes. Throughout the spring, Farington then kept an eye on a copyright bill to protect British sculptors from plagiarism, which was being steered smoothly through Parliament with the President’s support. Over the summer, West consulted Farington on the best ways of advising the Privy Council on designs for a new coinage, and later Farington was a contact for colleagues who were sub mitting drawings and models. At the same time, negotiations which he had been conducting with Treasury officials since the annual dinner in 1796 began to bear fruit, as the government commissioned Academicians to submit designs for national military monuments in St Paul’s Cathedral.
Тези доповідей конференцій з теми "RSA advisors":
1
Martins, Márcia, and Afshin Ashofteh. "A Systematic Review on Robo-Advisors in Fintech." In 23ª Conferência da Associação Portuguesa de Sistemas de Informação. Associação Portuguesa de Sistemas de Informação, APSI, 2023. http://dx.doi.org/10.18803/capsi.v23.160-185.
Анотація:
Technology has been the main driver for the financial sector. Fintech tools emerged to support the provision of financial services, especially Robo-Advisors (RAs), which allow the automation of the investment management process. The main functions are the creation of an investment portfolio and allocating assets, and daily management of investment portfolios based on a machine learning algorithm. This paper presents a literature review to summarise the importance of RAs in the financial sectors as well as the perception of investors. Also, this literature review presents the main algorithm’s characteristics behind the intelligence of RAs and the primary concerns. The Scopus and Web of Science databases revealed 114 research papers. It was found that investor acceptance of these technologies is affected by aspects of high volatility, which includes financial markets. The algorithm's mathematical models and system architecture might be improved so that this instrument can better suit the needs of investors.
2
"National Advisory Committee." In 2006 IEEE/RSJ International Conference on Intelligent Robots and Systems. IEEE, 2006. http://dx.doi.org/10.1109/iros.2006.282114.
3
"IROS 2006 Advisory Council." In 2006 IEEE/RSJ International Conference on Intelligent Robots and Systems. IEEE, 2006. http://dx.doi.org/10.1109/iros.2006.282115.
4
Mercader-Trejo, Flora. "Practice In The Industry as a Mean of Social Integration of Metrologists." In NCSL International Workshop & Symposium. NCSL International, 2015. http://dx.doi.org/10.51843/wsproceedings.2015.16.
Анотація:
Polytechnic University of Santa Rosa Jáuregui (UPSRJ) is a Mexican public institution where a new generation of metrologists is finishing the second year of studies leading to a bachelor degree as Industrial Metrology Engineers. The curriculum of the undergraduate program is based on the development of skills and to achieve this goal, the curriculum aims to develop two halftime stays at the end of the first and second year of study. Finally, the students complete their studies by a 600 hours full time third stay in the productive sector. The objective of practices is that students apply the skills acquired in school integrating theory and practice by case-based learning. The stay is performed under real-life conditions inside a company or in a research center or within a testing and calibration laboratory. The condition is that students develop short projects related to what they learned in college in the field of metrology and quality. During each stay, a university professor and a technical advisor belonging to the company guide the student. The professor will conduct the evaluation of the stay jointly by his counterpart in the company taking into account performance criteria previously defined. As part of the evidence of this process, the student will submit a report of the project results. This paper is a reflection of the results obtained through the experience of the students after the end of the second period of practical in-company. This practice ensures skilled metrologists with real-life training, but also facilitates the young people's transition into the labor market. This training strategy is a way to facilitate the social integration of the new generation in the workplace.
5
Twombly, Jeffrey G., Eric D. Cutright, and Kenneth K. Jackson. "Cost-Effective Risk Assessment of PTC Systems per FRA Rule 49CFR236 Subpart H." In 2009 Joint Rail Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/jrc2009-63020.
Анотація:
The US rail industry is charged with developing and implementing interoperable Positive Train Control (PTC) on many lines by 2015. It will be a challenge to assure the overall design safety of this next generation of train control, and there are significant issues with accommodating varying operating methods and different territories. The Federal Railroad Administration (FRA) will also require the railroads to meet the processor-based train control standards in FRA Rule 49CFR236 Sub-Part H (hereinafter FRA Rule 236H) [1], including the requirement for a comparative risk assessment, preferably quantitative. This paper provides an overview of the safety assurance process mandated by the FRA and discusses a cost-effective approach to performing risk assessments on large PTC systems. The paper also recognizes the current FRA and Railroad Safety Advisory Committee (RSAC) effort in developing the new PTC-specific FRA Rule 49CFR236 Sub-Part I to meet the recent PTC legislation requirements. The FRA Rule 236H requires railroads to use a comprehensive approach to generating a risk based, safety case for all PTC-type systems. Following the FRA Rule 236H guidelines helps ensure that all aspects of system safety are addressed, and that a safety conclusion can be successfully drawn from the documented evidence. The FRA requirements for building a safety case are based on time-tested traditional safety analyses which are enhanced to address system-wide safety. A critical new requirement of this standard is the development of a quantitative comparative risk assessment for the system as the formal mechanism for summarizing the safety argument. The FRA Rule 236H requires the comparison of the risk of the new PTC system with the historical risk of the existing system, which will be extremely challenging for the nationwide implementation of interoperable PTC where differing operating methods may be employed on multiple railroads with differing levels of appropriate historical data to reference. These factors must be carefully considered in the risk assessment approach and in the formulation of the overall system safety case argument for this Federally-mandated implementation. The risk assessment process described in this paper is uniquely different from existing quantitative safety assessment approaches that have primarily concentrated on producing a Mean Time Between Hazardous Events (MTBHE) for the various train control components in the system. In contrast to an MTBHE method, FRA rule-compliant comparative risk assessment approaches must evaluate PTC safety in the context of the overall comprehensive system operation, considering the effects of human errors, operating rules/procedures, training practices, system maintenance, equipment failures including any time/sequence dependencies, and the movement of trains and their exposure to potentially hazardous conditions. These considerations have prompted the development of a comprehensive FRA Rule 236H-compliant risk assessment methodology that goes far beyond traditional safety analyses and is well-suited for the assessment of interoperable PTC systems.
6
Carolan, Michael, A. Benjamin Perlman, and David C. Tyrell. "Criteria and Procedures for Assessing Occupied Volume Integrity." In ASME 2010 Rail Transportation Division Fall Technical Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/rtdf2010-42022.
Анотація:
With the potential for tremendous growth in the passenger rail industry, providing for the safety of the train-riding public and the crews who transport them becomes an ever-greater priority. To provide for safety while making best use of its resources and to facilitate passenger rail industry growth, the Federal Railroad Administration (FRA), in consultation with the rail industry, has developed alternative Criteria and Procedures for assessing the crashworthiness and occupant protection measures of rail passenger equipment. These Criteria and Procedures are intended to be applicable to a wide range of equipment designs, particularly equipment designs not complying with current U.S. standards and regulations. Because the latest technology in rail equipment crashworthiness has been used to develop the Criteria and Procedures, aspects of the resulting Criteria and Procedures are fundamentally different from their corresponding regulations. While technical results from sophisticated analyses and tests have been necessary, judgment was also needed to develop the Criteria and Procedures. This judgment was provided by the Engineering Task Force (ETF), and ultimately accepted by FRA. The ETF is a government/industry working group, organized under the auspices of the Railroad Safety Advisory Committee (RSAC). The Criteria and Procedures are intended to provide an engineering-based methodology for comparing the crashworthiness of alternatively-designed equipment with that of compliant designs. One particularly important aspect of passenger car crashworthiness is occupied volume integrity (OVI). It is essential that all passenger vehicles meet some base minimum level of OVI. A primary goal of crashworthiness is to maintain a volume for occupants to ride out a collision. In the U.S., this base level has been demonstrated through a vehicle’s ability to react a quasi-static load of 800,000 pounds along its line of draft without experiencing permanent deformation. This car-level requirement has existed, in some form, since the early 20th century. However, alternatively-designed vehicles may not be able to demonstrate the ability to support this load, but may still prove to be equivalently crashworthy. Based on analyses performed on conventional and alternatively-designed passenger equipment, three options have been developed to demonstrate the OVI of alternatively-designed equipment. These options consist of three load magnitudes placed along the collision load path with a corresponding pass/fail criterion for each load. OVI may be demonstrated by sustaining an 800,000 pound load with no permanent deformation, a 1,000,000 pound load with limited permanent deformation, or a 1,200,000 pound load without exceeding the crippling load of the occupied volume. This paper discusses the pass/fail criteria associated with each option, the analysis and test procedures used in applying each option, and the technical basis used in developing the Criteria and Procedures for OVI evaluation. By applying such techniques, the results of evaluations of alternatively-designed equipment can be compared with the Criteria values for compliant designs. In this manner, the crashworthiness performance of alternatively-designed equipment can be assessed relative to the performance of compliant designs. A companion paper to this one discusses the development of the train-level Criteria and Procedures.
7
Carolan, Michael, Benjamin Perlman, and David Tyrell. "Crippling Test of a Budd Pioneer Passenger Car." In 2012 Joint Rail Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/jrc2012-74087.
Анотація:
This research program was sponsored by the Federal Railroad Administration (FRA) Office of Research and Development in support of the advancement of improved safety standards for passenger rail vehicles. FRA and the Volpe National Transportation Systems Center (Volpe Center) have conducted a research program to develop alternative methods for demonstrating occupied volume integrity (OVI) of passenger rail cars using a combination of testing and analysis. Previous publications have addressed the planning and progress of a series of tests intended to examine the collision load path through the occupant volume of passenger cars equipped with crash energy management (CEM) systems. This program has included an elastic 800-kip buff strength test, two quasi-static tests that loaded a passenger car to its ultimate (crippling) capacity, and corresponding finite element (FE) analyses of each test. This paper discusses the two crippling tests and the companion FE analyses. One alternative method for evaluating OVI moves the applied loads from the line of draft to the collision load path. This alternative methodology also permits a combination of testing and analysis to be used to demonstrate the car’s OVI, in contrast to the conventional methodology (as prescribed in existing FRA regulations) which only permits testing. The alternative methodology was adopted as the recommendations developed by the Railroad Safety Advisory Committee’s (RSAC) Engineering Task Force (ETF) in its “Technical Criteria and Procedures for Evaluating the Crashworthiness and Occupant Protection Performance of Alternatively-Designed Passenger Rail Equipment for Use in Tier I Service.” The research program was undertaken to verify the efficacy of using a combination of elastic testing and plastic analysis to evaluate the OVI of a passenger car loaded along its collision load path as prescribed in the ETF report. Earlier in this research program an elastic test of a Budd Pioneer car was used to validate an FE model of the car, per the ETF’s procedures. This model was then modified to reflect the condition of the car in its crippling test configuration. The model was used to simulate the crippling behavior of the car, following the ETF’s procedures. Two Pioneer cars were then tested to crippling to provide additional data to validate the FE model and the proposed alternative OVI evaluation. Because the test cars used in this research program were equipped with CEM systems, the alternative evaluation loads were placed at the locations where the energy-absorbing components attached to the occupant volume. During both crippling tests, loads were measured at each energy-absorber support location on the live and restrained ends of the car. Additional instrumentation used in the second crippling test included strain gages on the major longitudinal structural members, displacement transducers at each load location, and vertical, lateral, and longitudinal displacement transducers on the underframe of the car. The results of the FE analysis compare favorably with the results of the crippling tests. In particular, the crippling loads are consistent between the tests and analysis: crippling loads for the first and second cars tested were 1.15 and 1.19 million pounds respectively, and the pre-test FEA estimated a crippling load of 1.19 million pounds. The research program has established a technical basis for the alternative OVI requirements and methodology.
Звіти організацій з теми "RSA advisors":
1
Baudais, Virginie, Annelies Hickendorff, Jaïr van der Lijn, Igor Acko, Souleymane Maiga, and Hussein Yusuf Ali. EU Military Training Missions: A Synthesis Report. Stockholm International Peace Research Institute, May 2022. http://dx.doi.org/10.55163/lfle9658.
Анотація:
This paper draws overarching conclusions based on a synthesis of previously published case studies that examined the impact of EU military training missions (EUTMs) in Somalia (EUTM Somalia, 2010–), Mali (EUTM Mali, 2013–), the Central African Republic (CAR) (EUTM RCA, 2016–). It concludes that EUTMs are relevant niche operations. Despite difficult circumstances beyond the control of the missions, EUTM training and advisory efforts have increased the effectiveness of partner armed forces. While these gains have been marginal in CAR and Somalia, they have been a bit more pronounced in Mali. Yet, broader security sector reform and defence sector reform efforts to improve the accountability and governance of defence and security sectors have become bogged down. The main challenge is that EUTMs are generally mandated to implement largely technical and tactical agendas in contexts where the ongoing armed conflict and the politics of the security sector are not conducive to building professional national security forces. As a consequence EUTMs find themselves caught up in interlinked and partially overlapping dilemmas. This study concludes with seven partly overlapping recommendations to EU member states and to EUTMs to address the main limitations that are restricting the impact of the missions.