Дисертації з теми "RNA localization and translation"
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Ciolli, Mattioli Camilla. "Post-transcriptional mechanisms contributing to RNA and protein localization: study of local translation and alternative 3′UTRs in induced neurons." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20702.
Повний текст джерелаAsymmetric distribution of mRNA and proteins inside a cell defines polarity, which allow tight regulation of gene expression in space and time. In this thesis I investigated how asymmetric distribution characterizes the somatic and neuritic compartments of in induced neurons, in terms of transcriptome and translatome. Spatial ribosome profiling analysis revealed that half of the local proteome is defined by mRNA localization and local translation. These, are processes accomplished by the synergistic activity of trans- and cis-acting elements. I focused on MOV10 as trans-acting element, and on alternative 3′UTRs as cis-elements, to investigate their role in asymmetry. MOV10 is an RNA helicase which participates to many aspects of RNA metabolism. With RIP and PAR-CLIP I showed that MOV10 targets are localized to the neurites, consistently with MOV10-neuritic localization, and that MOV10 might be involved in translational repression. Indeed, among MOV10 protein interactors, I identified several proteins involved in translational repression, i.e. AGO2, FMR1, and TRIM71. On the side of cis-elements, I performed mapping of alternative 3′UTRs. This analysis identified several genes expressing differentially localized 3′UTR isoforms. In particular, I focused on Cdc42. I showed that the two isoforms of Cdc42 are differentially localized at mRNA level, and that the 3′UTR is the driver of mRNA and protein localization. Moreover, I identified several RBPs that might be involved in Cdc42 localization. This analysis points to usage of alternative 3′UTR isoforms as a novel mechanism to provide for differential localization of functionally diverse alternative protein isoforms.
Rongo, Christopher Gabriel. "The role of RNA localization and translational regulation in Drosophila germ cell determination." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10562.
Повний текст джерелаVicario, Annalisa. "Analysis of the molecular mechanisms of BDNF mRNA localization and traslation in neurons." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3664.
Повний текст джерелаLa regolazione dell’espressione genica rappresenta uno fenomeno fondamentale per garantire la sopravvivenza e la corretta funzione cellulare. In strutture complesse ed altamente specializzate come il sistema nervoso, la grande varietà morfologica e funzionale, la rapidità di interscambio di comunicazioni e di adattamento richiede un’altrettanto fine regolazione spazio-temporale dell’espressione genica. I livelli di regolazione sono molteplici e includono lo splicing alternativo, la regolazione del turnover degli mRNA, modifiche post-traduzionali ed il controllo traduzionale. La segregazione dei trascritti in diversi compartimenti subcellulari rappresenta un ulteriore meccanismo che permette di concentrare le proteine in specifici domini cellulari mediante traduzione localizzata. A partire dagli anni ’80 sono stati scoperti numerosi mRNA a livello dendritico, tra cui i trascritti codificanti Brain Derived Neurotrophic Factor (BDNF) ed il suo recettore TrkB (Tongiorgi et al., 1997). L’mRNA per BDNF si localizza nei dendriti in risposta all‘attività elettrica e al BDNF in vitro e in seguito a crisi epilettogeniche indotte in vivo (Tongiorgi et al., 1997, 2004; Righi et al., 2000). La segregazione degli mRNA nei neuriti presuppone la potenziale traduzione in loco a seguito di specifici stimoli. A tal supporto vi è la dimostrazione della presenza di fattori coinvolti nella sintesi proteica (poliribosmi, tRNA, eIFs, eEFs, marker del reticolo endoplasmatico e del golgi) alla base delle spine dendritiche (Steward and Levi,1982; Tiedge and Brosius, 1996). Le dinamiche del trasporto coinvolgono elementi in trans, le RNA binding proteins, , ed elementi in cis, riconosciuti dalle proteine di trasporto. Questi ultimi sono solitamente confinati nella regione 3’UTR (Bashirullah et al., 1998), in misura inferiore all’interno della regione codificante (CDS) (Mohr, 1999; Chiaruttini et al., 2009) e dei 5’UTR (Muslimov et al., 1997). Tra le più comuni RBPs annoveriamo CPEB, ZBP, hnRNP, Staufen, FMRP, Translin e le proteine ELAV. Ricordiamo come molte di queste proteine di trasporto degli mRNA siano in realtà repressori della traduzione, al fine di prevenirne l’espressione ectopica durante il trasporto. Le RBPs che si legano all’mRNA di BDNF non sono ancora note, tuttavia nel corso di questo studio, mediante ibridazioni in situ non radioattiva su colture ippocampali/sezioni di cervello di topo è stata scoperta un serie di elementi in cis che regolano la localizzazione del trascritto. Alla luce dei risultati ottenuti, emerge un complesso quadro di regolazione post-trascrizionale e traduzionale di BDNF. L’RNA endogeno si localizza nel compartimento dendritico distale in seguito ad attività elettrica ed applicazione di BDNF od NT-3. I segnali di trasporto sensibili sono molteplici e distribuiti in diverse regioni dell’mRNA: un segnale costitutivo a carico della CDS(riconosciuto da translin), due segnali inducibili a livello del 3’UTR short (KCL ed NT-3, riconosciuti da CPEB1 e 2, ELAV2 e 4) ed altrettanti a livello 3’UTR long (KCl e BDNF, target di ELAV e CPEB), in aggiunta ad un segnale di ritenzione all’interno della stessa regione (osservato anche in topi KO per FXR2 ed FMRP). La modulazione del trasporto del 3’UTR long è di gran lunga più finemente regolata rispetto alla variante short, e ricorda il comportamento del 3’UTR della CaMKII (Mori et al., 2000), anch’esso coinvolto nella plasticità e potenziamento sinaptici. Dal punto di vista traduzionale, la distinzione tra 3’UTR short e long è netta: per quanto riguarda il primo, il meccanismo è piuttosto lineare e viene attivato dalla cascata del glutammato/Aurora chinasi/CPEB, mentre per il secondo, scarsamente traducibile, sembra sia necessaria la compresenza di più stimoli per attivarne la corretta traduzione, suggerendo come il 3’UTR long possa rappresentare un “coincidence detector“ che viene attivato solo in particolari contesti, a traccia di una complessa attività sinaptica. Dagli studi condotti siamo stati in grado di costruire un modello che possa spiegare come un trascritto così complesso possa rispondere a diversi stimoli. La CDS contiene un segnale di trasporto costitutivo mediato da translin, che in condizioni basali viene soppresso da un elemento inibitorio all’interno del 3’UTR long. In seguito ad attivazione viene meno la repressione in modo da favorire il trasporto del trascritto mediato dai due segnali di targeting (CDS e 3’long). Per quanto riguarda i trascritti contenenti la variante short, invece, sembra non vi siano segnali di ritenzione, bensì elementi di trasporto che vengono attivati in seguito ad uno specifico stimolo extracellulare (KCL od NT3).
XXII Ciclo
1982
Ohler, Uwe [Gutachter], Florian [Gutachter] Heyd, and Chakrabarti [Gutachter] Sutapa. "Post-transcriptional mechanisms contributing to RNA and protein localization: study of local translation and alternative 3′UTRs in induced neurons / Gutachter: Uwe Ohler, Florian Heyd, Chakrabarti Sutapa." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1199930695/34.
Повний текст джерелаMaderazo, Alan Baer. "A Study on the Cellular Localization of Factors Involved in Yeast Nonsense-Mediated mRNA Decay and their Mechanisms of Control on Nonsense mRNA Translation: a Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/105.
Повний текст джерелаEliscovich, Carolina. "Spindle-Localized CPE-Mediated Translation Controls Mediotic Chromosome Segregation." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7123.
Повний текст джерелаEn este trabajo que derivó en mi tesis doctoral, hemos demostrado que la activación traduccional localizada en el huso mitótico de mRNAs regulados por CPEB que codifican para proteinas con una conocida función en aspectos estructurales del ciclo celular como la formación del huso mitótico y la segregación cromosómica, es esencial para completar la primera división meiótica y para la correcta segregación cromosómica en oocitos de Xenopus.
Reynolds, Joanna Elizabeth. "Initiation of hepatitis C virus RNA translation." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264546.
Повний текст джерелаHunt, Sarah Louise. "Cellular proteins required for rhinovirus RNA translation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313880.
Повний текст джерелаLempke, Carola. "Internal initiation of translation of cardiovirus RNA." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624267.
Повний текст джерелаDonlevy, Alison. "Regulation of RNA translation by phenethyl isothiocyanate." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/362491/.
Повний текст джерелаIwakawa, Hirooki. "Translation and RNA replication mechanisms of Dianthovirus." Kyoto University, 2010. http://hdl.handle.net/2433/120491.
Повний текст джерела0048
新制・課程博士
博士(農学)
甲第15448号
農博第1833号
新制||農||982(附属図書館)
学位論文||H22||N4547(農学部図書室)
27926
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 奥野 哲郎, 教授 遠藤 隆, 教授 荒木 崇
学位規則第4条第1項該当
Saini, Harleen. "Intron and Small RNA Localization in Mammalian Neurons." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1044.
Повний текст джерелаJohnston, Julie Catherine. "In vitro translation of cucumber necrosis virus RNA." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28969.
Повний текст джерелаLand and Food Systems, Faculty of
Graduate
Starmer, Joshua Mr. "What can RNA hybrids tell us about translation?" NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-10202006-155443/.
Повний текст джерелаHowell, Michael Terence. "The mechanism of initiation of poliovirus RNA translation." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386094.
Повний текст джерелаBorman, Andrew Mark. "Internal initiation of translation of human rhinovirus RNA." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281908.
Повний текст джерелаQin, Daoming. "Role of 16S Ribosomal RNA in Translation Initiation." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299007063.
Повний текст джерелаLeipuvienė, Ramunė. "Frameshifting as a tool in analysis of transfer RNA modification and translation /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-302.
Повний текст джерелаDaughenbaugh, Katie Finney. "The role of VPg in translation of calicivirus RNA." Diss., Montana State University, 2005. http://etd.lib.montana.edu/etd/2005/daughenbaugh/DaughenbaughK1205.pdf.
Повний текст джерелаMéthot, Nathalie. "RNA and protein interactions by eIF4B during translation initiation." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40401.
Повний текст джерелаBrown, E. C. "Cellular proteins involved in translation of human rhinovirus RNA." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596963.
Повний текст джерелаDeumer, Claudia D. "RNA-binding proteins in yeast mitochondria." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2002. http://nbn-resolving.de/urn:nbn:de:swb:14-1035897639531-83407.
Повний текст джерелаPizzinga, Mariavittoria. "Granules of translation factor mRNAs and their potential role in the localisation of the translation machinery to regions of polarised growth." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/granules-of-translation-factor-mrnas-and-their-potential-role-in-the-localisation-of-the-translation-machinery-to-regions-of-polarised-growth(9cb42e69-3c8c-4f10-b79f-ba8261be4430).html.
Повний текст джерелаDoyle, Olivia E. "Cajal bodies sites of RNA polymer II localization and modification /." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080652.
Повний текст джерелаButsch, Melinda Sue. "Control of Retroviral Translation and Relationship to Genomic RNA Packaging." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1029510697.
Повний текст джерелаDienstbier, Martin. "Recognition of mRNA localization signals in Drosophila development." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608472.
Повний текст джерелаBourdeau-Julien, Isabelle. "ALS-associated RNA-binding protein FUS and mRNA translation regulation." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/68742.
Повний текст джерелаMutations in several genes have been linked to amyotrophic lateral sclerosis (ALS),particularly in the gene coding for the Fused in Sarcoma protein (FUS). Those mutations are found in the part encoding for the nuclear localization signal, making the protein abnormallyabundant in the cytoplasm. Combined with other observations, it suggests that a toxic gainof function of FUS in the cytoplasm would be the cause of the neurodegeneration. ALS is a neurodegenerative disease that affects motor neurons and causes progressive paralysis. The molecular mechanisms causing the disease are still unknown. One of the hypotheses is the disruption of local translation of mRNAs, which allows synapses to respond quickly and independently from the cell body. Insufficient local translation to support long-term synapticactivity would lead to synaptic loss and neurodegeneration. Thereby, the objective of mystudy is to determine the role of FUS in the regulation of mRNA translation by characterizing its interaction with translational components and evaluate its function in an ALS-linked condition. I have shown that FUS is associated with stalled polyribosomes, which suggests that it plays a role in regulating mRNA translation by interacting with the core of translation.There is also an increase in the presence of FUS in the cytoplasm and in its interaction with polyribosomes following inhibition of translation through mTOR, suggesting its role as anegative regulator. In addition, ALS-related mutations amplify FUS inhibitory function bymaking FUS cytoplasmic and reducing protein synthesis. My results show that the FUSprotein would have a role as a translation inhibitor when it is cytoplasmic. There fore, increasing the presence of FUS in the cytoplasm in ALS would result in significant translation inhibition, at a level insufficient to support synaptic activity.
Yoon, Young J. "Role of Xenopus staufen and kinesin I in vegetal RNA localization /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174705.
Повний текст джерелаHalsell, Susan Richardson Lipshitz Howard D. Lipshitz Howard D. "Expression and localization of Hsp83 RNA in the early Drosophila embryo /." Diss., Pasadena, Calif. : California Institute of Technology, 1995. http://resolver.caltech.edu/CaltechETD:etd-10092007-075248.
Повний текст джерелаRIBEIRO, GABRIELA CASTELO BRANCO. "MACHINE TRANSLATION EVALUATION FOR THE SOFTWARE LOCALIZATION INDUSTRY: A CASE STUDY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9105@1.
Повний текст джерелаEste estudo foi motivado pela utilização, ainda em caráter experimental, de um tradutor automático por uma empresa multinacional de localização de software. A fim de contribuir para essa iniciativa pioneira no país, propomos uma avaliação do programa, enfocando as implicações da utilização desta tecnologia no processo de localização de software. Empregamos a taxonomia proposta pelo FEMTI (Framework for the Evaluation of Machine Translation in ISLE), desenvolvida especialmente para a avaliação de tradução automática, com base nas normas ISO/IEC de qualidade de software. São considerados aspectos operacionais, como a integração do sistema de tradução automática às ferramentas de memória de tradução, bem como questões relacionadas à linguagem. O corpus utilizado para a avaliação foi um manual de usuário de um telefone celular. Além dos problemas lingüísticos recorrentes na maioria das ferramentas de tradução automática disponíveis atualmente, são analisados os desvios relacionados à tradução da interface com o usuário, mais especificamente aos menus do telefone celular. Esses desvios são discutidos dentro das categorias pertinentes da taxonomia do FEMTI e, sempre que possível, foram sugeridas soluções. Para complementar a análise lingüística, apresentamos outros três estudos realizados para o português. Nossos resultados indicam que o sistema pode ser bem-sucedido neste mercado em função principalmente da delimitação do domínio e da adoção dos procedimentos impostos pelo processo de localização. Esse sucesso depende da integração do tradutor automático às memórias de tradução e de investimentos relativamente pequenos na atualização dos recursos lingüísticos (regras gramaticais e dicionários) para refletir as características próprias do domínio e do tipo de texto.
This study was motivated by the trial implementation of a machine translation engine by a multinational software localization company. In order to contribute to this innovative experiment in the Brazilian market, we evaluate the engine, focusing on the implications of its implementation in the software localization industry. We use the FEMTI (Framework for the Evaluation of Machine Translation in ISLE) taxonomy, which is based on the ISO/IEC guidelines for software evaluation. Operational aspects, such as the engine s integration with translation memory tools, are taken into consideration, as well as language issues. Our evaluation is based on the machine translated version of a mobile phone user guide. In addition to the language problems common to most machine translation engines currently available, we analyze issues related to the user interface, particularly to the phone menus. These problems are discussed as examples of each related FEMTI topic and we suggest solutions whenever possible. To add to our language evaluation, we present three other studies dedicated to Portuguese. Our results indicate the engine can be successful in this industry mainly in terms of domain restriction and localization workflow procedures. Its success depends on its integration to translation memory tools and requires relatively little investment in updating the language resources (rules and dictionaries) to reflect the language characteristics specific to domain and text type.
Kumari, Sunita. "Role of RNA G-quadruplexes within 5' UTRs in translation regulation." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612262.
Повний текст джерелаSwift, Michael A. "Identification of RNA-binding proteins associated with H19 lncRNA translation avoidance." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1302.
Повний текст джерелаSweet, Thomas Jeffrey. "New Insights Into the Relationship Between Messenger RNA Translation and Degradation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1321298653.
Повний текст джерелаLeen, Eoin. "Structural insights into the transcription and translation of murine norovirus RNA." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11173.
Повний текст джерелаSARAWANEEYARUK, SIRIRUK. "Studies on Cap-Independent Translation and RNA Replication Mechanisms of Dianthovirus." Kyoto University, 2010. http://hdl.handle.net/2433/131903.
Повний текст джерела0048
新制・課程博士
博士(農学)
甲第15733号
農博第1845号
新制||農||985(附属図書館)
学位論文||H22||N4468(農学部図書室)
28278
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 奥野 哲郎, 教授 遠藤 隆, 教授 左子 芳彦
学位規則第4条第1項該当
Karakasiliotis, Ioannis. "Analysis of RNA-protein interactions involved in calicivirus translation and replication." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/1304.
Повний текст джерелаKrech, Sabine. "Translation of the genomic RNA of hepatitis A virus in vitro /." [S.l : s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаNashchekin, Dmitri. "A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-811-8/.
Повний текст джерелаPresnyak, Vladimir. "Effects of Codon Usage on mRNA Translation and Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427387336.
Повний текст джерелаGillespie, Doreen. "The role of homeless in RNA transport and localization during Drosophila oogenesis /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10305.
Повний текст джерелаZimmermann, C. "Regulation of mRNA localization, stability and local translation in sympathetic neuron axons." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1405619/.
Повний текст джерелаCridge, Andrew Graham, and n/a. "Characterization of the eukaryotic translation termination sequence element." University of Otago. Department of Biochemistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20060804.095722.
Повний текст джерелаCrandall, Jacob N. "Ribosomal RNA Mutations that Inhibit the Activity of Transfer-Messenger RNA of Stalled Ribosomes." Diss., CLICK HERE for online access, 2010. http://contentdm.lib.byu.edu/ETD/image/etd3535.pdf.
Повний текст джерелаGill, Kirsty. "Elucidating the molecular mechanism that determines the specific localisation of gurken mRNA during Drosophila development." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:01e61a3d-b29f-4766-b8c8-81552e5cd11d.
Повний текст джерелаBilali, Loubna. "Localization Training: Towards an Industry-based Requirements-Gathering Model." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532649023272877.
Повний текст джерелаLeipuviene, Ramune. "Frameshifting as a tool in analysis of transfer RNA modification and translation." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-302.
Повний текст джерелаFred, Rikard G. "The Role of RNA Binding Proteins in Insulin Messenger Stability and Translation." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130234.
Повний текст джерелаSubhan, Syed Abdus. "Dissecting the initiation factors required for translation initiation on feline calicivirus RNA." Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543924.
Повний текст джерелаChuang, Ray-Yuan. "Requirement of a putative RNA helicase, ded1p, for translation in saccharomyces cerevisiae /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948158625166.
Повний текст джерелаSartor, Francesca. "Regulation of translation initiation and RNA decay is important for neuronal differentiation." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=.
Повний текст джерела