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Статті в журналах з теми "Ribosome biogensis"
Moraleva, Anastasia A., Alexander S. Deryabin, Yury P. Rubtsov, Maria P. Rubtsova, and Olga A. Dontsova. "Eukaryotic Ribosome Biogenesis: The 40S Subunit." Acta Naturae 14, no. 1 (May 10, 2022): 14–30. http://dx.doi.org/10.32607/actanaturae.11540.
Повний текст джерелаMoraleva, Anastasia A., Alexander S. Deryabin, Yury P. Rubtsov, Maria P. Rubtsova, and Olga A. Dontsova. "Eukaryotic Ribosome Biogenesis: The 60S Subunit." Acta Naturae 14, no. 2 (July 21, 2022): 39–49. http://dx.doi.org/10.32607/actanaturae.11541.
Повний текст джерелаSulima, Sergey, Kim Kampen, and Kim De Keersmaecker. "Cancer Biogenesis in Ribosomopathies." Cells 8, no. 3 (March 11, 2019): 229. http://dx.doi.org/10.3390/cells8030229.
Повний текст джерелаKonikkat, Salini, and John L. Woolford,. "Principles of 60S ribosomal subunit assembly emerging from recent studies in yeast." Biochemical Journal 474, no. 2 (January 6, 2017): 195–214. http://dx.doi.org/10.1042/bcj20160516.
Повний текст джерелаPecoraro, Annalisa, Martina Pagano, Giulia Russo, and Annapina Russo. "Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins." International Journal of Molecular Sciences 22, no. 11 (May 23, 2021): 5496. http://dx.doi.org/10.3390/ijms22115496.
Повний текст джерелаLavdovskaia, Elena, Kärt Denks, Franziska Nadler, Emely Steube, Andreas Linden, Henning Urlaub, Marina V. Rodnina, and Ricarda Richter-Dennerlein. "Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes." Nucleic Acids Research 48, no. 22 (December 2, 2020): 12929–42. http://dx.doi.org/10.1093/nar/gkaa1132.
Повний текст джерелаSlimane, Sophie Nait, Virginie Marcel, Tanguy Fenouil, Frédéric Catez, Jean-Christophe Saurin, Philippe Bouvet, Jean-Jacques Diaz, and Hichem C. Mertani. "Ribosome Biogenesis Alterations in Colorectal Cancer." Cells 9, no. 11 (October 27, 2020): 2361. http://dx.doi.org/10.3390/cells9112361.
Повний текст джерелаJovanovic, Bogdan, Lisa Schubert, Fabian Poetz, and Georg Stoecklin. "Tagging of RPS9 as a tool for ribosome purification and identification of ribosome-associated proteins." Archives of Biological Sciences, no. 00 (2020): 57. http://dx.doi.org/10.2298/abs20120557j.
Повний текст джерелаTemaj, Gazmend, Silvia Chichiarelli, Margherita Eufemi, Fabio Altieri, Rifat Hadziselimovic, Ammad Ahmad Farooqi, Ilhan Yaylim, and Luciano Saso. "Ribosome-Directed Therapies in Cancer." Biomedicines 10, no. 9 (August 26, 2022): 2088. http://dx.doi.org/10.3390/biomedicines10092088.
Повний текст джерелаPelava, Andria, Claudia Schneider, and Nicholas J. Watkins. "The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease." Biochemical Society Transactions 44, no. 4 (August 15, 2016): 1086–90. http://dx.doi.org/10.1042/bst20160106.
Повний текст джерелаДисертації з теми "Ribosome biogensis"
Dator, Romel P. "Characterization of Ribosomes and Ribosome Assembly Complexes by Mass Spectrometry." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1382373082.
Повний текст джерелаBurlacu, Elena. "Probing ribosomal RNA structural rearrangements : a time lapse of ribosome assembly dynamics." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/17072.
Повний текст джерелаGartmann, Marco. "Structural characterization of ribosomal complexes involved in ribosome biogenesis and protein folding." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-120476.
Повний текст джерелаZakari, Musinu. "The SMC loader Scc2 promotes ncRNA biogenesis and translational fidelity in Saccharomyces cerevisiae." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066148/document.
Повний текст джерелаThe Scc2-Scc4 complex is essential for loading the cohesin complex onto DNA. Cohesin generates cohesion between sister chromatids, which is critical for chromosome segregation. Scc2 (also known as NIPBL) is mutated in patients with Cornelia de Lange syndrome, a multi-organ disease characterized by developmental defects in head, limb, cognition, heart, and the gastrointestinal tract. How mutations in Scc2 lead to developmental defects in patients is yet to be elucidated. One hypothesis is that the binding of Scc2/cohesin to different regions of the genome will affect transcription. In budding yeast, Scc2 has been shown to bind to RNA Pol III transcribed genes (tRNAs, and spliceosomal), as well as RNA Pol II-transcribed genes encoding small nuclear and nucleolar RNAs (snRNAs and snoRNAs) and ribosomal protein genes. Here, we report that Scc2 is important for gene expression. Scc2 and the transcriptional regulator Paf1 collaborate to promote the production of Box H/ACA snoRNAs which guide pseudouridylation of RNAs including ribosomal RNA. Mutation of Scc2 was associated with defects in the production of ribosomal RNA, ribosome biogenesis, and splicing. While the scc2 mutant does not have a general defect in protein synthesis, it shows increased frameshifting and reduced internal ribosomal entry site (IRES) usage/cap-independent translation. These findings suggest Scc2 normally promotes a gene expression program that supports translational fidelity. We hypothesize that translational dysfunction may contribute to the human disorder Cornelia de Lange syndrome, which is caused by mutations in Scc2
Ramesh, Madhumitha. "Analysis of Ribosome Biogenesis from Three Standpoints: Investigating the Roles of Ribosomal RNA, Ribosomal Proteins and Assembly Factors." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/609.
Повний текст джерелаTherizols, Gabriel. "Rôle des ribosomes et de leur biogenèse dans la tumorigenèse et la réponse aux traitements chimiothérapeutiques." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10083/document.
Повний текст джерелаCancer cells produce large amounts of ribosomes to synthesize the proteins required for their rapid proliferation. The mechanisms leading to this increase in ribosome production are only partly understood, but they are related to the acquisition of the tumor phenotype. In addition, a new theory proposes that ribosomes are not neutral effectors of translation, but have a direct role in the regulation of gene expression. This theory is based on the observation that ribosome composition is heterogeneous in different cell types and according to environmental conditions. In this context, I have analyzed the relationships between changes in signals that control ribosome biogenesis, both quantitatively and qualitatively, and the development of the tumor phenotype. This manuscript reports three studies made during this PhD program. These studies identified: i) a novel regulator of the amount of ribosomes, the LN-Netrin-1 and ii) changes in the ribosome composition and function induced by genetic alterations (loss of activity of p53) and by the use of a chemotherapeutic molecule, the 5-Fluorouracil. These perturbations of the amount and the function of ribosomes modify the translation control and cell growth, cell proliferation and cell survival. From these results it can be conclude that ribosomes are elements involved in the regulation of gene expression and play a role in cancer pathology and response to chemotherapy
G, C. Keshav. "Investigation of the Role of Bacterial Ribosomal RNA Methyltransferase Enzyme RsmC in Ribosome Biogenesis." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1621868567263046.
Повний текст джерелаBouffard, Stéphanie. "Study of ribosome biogenesis factors in zebrafish neural progenitors." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS228/document.
Повний текст джерелаWhile ribosome biogenesis has been consideredas an ubiquitous mechanism, steps of thisprocess have recently been shown to be tissuespecific. Zebrafish optic tectum (OT) is asuitable model to study cell proliferation sincecells at different differentiation states arespatially partitioned.During my PhD, I examined whether ribosomebiogenesis genes may have specific roles inneuroepithelial progenitor cells (NePCs).Taking advantage of a previous transcriptomicanalysis, I first screened for new candidatesaccumulated in NePCs. I decided to focus onproliferation-associated 2G4 (pa2g4/ebp1),which was expressed preferentially in NePCs.This gene promotes or represses cellproliferation in normal organisms or duringtumorigenesis. I designed a strategy for theinducible expression and cell specificexpression of this gene.Fibrillarin (Fbl), a small nucleolarmethyltransferase is also preferentiallyexpressed in NePCs. It plays an important rolein cancer. I showed that fbl mutants displayedspecific OT defects linked to a massiveapoptosis and an absence of neuraldifferentiation. I also demonstrated deficienciesin the ribosome translational activity.Additionally, fbl mutants showed impaired Sphaseprogression. Our data suggest that fbl isessential for the proliferation of zebrafishneuronal progenitors
Deraze, Jérôme. "Epigenetic control of ribosome biogenesis homeostasis." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066342/document.
Повний текст джерелаTranslation is an essential metabolic activity carried by ribosomes. These complexes are synthetized in the nucleolus, and require the coordinated expression of 4 ribosomal RNA, 80 ribosomal proteins, and more than 200 assembly factors. Indeed, their biogenesis is complex and expensive, consuming more than half of the energy in proliferating cells. As the cellular need for ribosomes varies with environmental or metabolic conditions, their synthesis is tightly regulated in response to a number of cues. Many mechanisms ensure that the intensity of ribosome biogenesis is coupled to cell homeostasis. Such is the ability of ribosomal proteins to regulate gene expression at many levels, from translation specificity to activation or repression of transcription. Many such functions are carried off the ribosome, and are thus termed extraribosomal. Our team discovered a new extraribosomal function of ribosomal protein uL11 in Drosophila. Indeed, when trimethylated on lysine 3 (uL11K3me3), it associates with Corto, a transcription factor of the Enhancers of Trithorax and Polycomb family. By studying their genome-wide binding profile on chromatin, we show that these proteins are distributed along different patterns, and that uL11K3me3 specifically binds a subset of active genes enriched in ribosome biogenesis components. Additionally, we generated the first genetic alleles for Drosophila uL11 and describe the molecular screening method that we employed. Last, we studied the uL11 alleles that delete or replace lysine 3. We describe that their Minute-like phenotypes suggest an essential role for the N-terminal domain of uL11, though it may be independent of its association with Corto
Nguyen, Van Long Flora. "Altérations de composition des ribosomes dans les cancers du sein : analyses de cohortes humaines et modèles cellulaires." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1095/document.
Повний текст джерелаRibosomes are responsible of translating mRNAs to proteins. Alterations of ribosome composition modify its translation activity and favour tumourigenesis. Identification of ribosomes composition alterations in breast cancers might correspond to a new mechanism responsible of mammary tumourigenesis and might open up novel therapeutic approaches. Indeed breast cancers represent the first cause of women mortality due to cancers and their heterogeneity induces an important therapeutic problem.In this context, alterations of ribosomes composition were determined in human cohorts and in EMT (Epithelial to Mesenchymal Transition) cellular models, the EMT being a process involved in mammary tumourigenesis. This studies identify : (i) two factors involved in ribosome biogenesis, FBL (fibrillarin) and NCL (nucleolin) whose expression variations are associated with poor prognosis in patients and (ii) variations of ribosome composition and its translational activity in EMT. Altogether, this data support the presence of ribosomes composition alterations in breast cancers
Книги з теми "Ribosome biogensis"
Entian, Karl-Dieter, ed. Ribosome Biogenesis. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9.
Повний текст джерелаThe nucleolus and ribosome biogenesis. Wien: Springer-Verlag, 1985.
Знайти повний текст джерелаHadjiolov, Asen A. The Nucleolus and Ribosome Biogenesis. Vienna: Springer Vienna, 1985. http://dx.doi.org/10.1007/978-3-7091-8742-5.
Повний текст джерелаHadjiolov, A. A. Nucleolus and Ribosome Biogenesis. Springer, 2012.
Знайти повний текст джерелаRibosome Biogenesis: Methods and Protocols. Springer, 2022.
Знайти повний текст джерелаHadjiolov, A. A. The Nucleolus and Ribosome Biogenesis. Springer, 2011.
Знайти повний текст джерелаEntian, Karl-Dieter. Ribosome Biogenesis: Methods and Protocols. Springer, 2022.
Знайти повний текст джерелаSteinbauer, Robert. Regulation of ribosome biogenesis and RNA polymerase I transcription: How nutrients control the synthesis of ribosomes. Südwestdeutscher Verlag für Hochschulschriften, 2011.
Знайти повний текст джерелаLondei, Paola, Anna La Teana, and Sébastien Ferreira-Cerca, eds. Archaeal Ribosomes: Biogenesis, Structure and Function. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-141-0.
Повний текст джерелаHadjiolov, A. A. The Nucleolus and Ribosome Biogenesis (Cell Biology Monographs). Springer, 1985.
Знайти повний текст джерелаЧастини книг з теми "Ribosome biogensis"
Oborská-Oplová, Michaela, Ute Fischer, Martin Altvater, and Vikram Govind Panse. "Eukaryotic Ribosome assembly and Nucleocytoplasmic Transport." In Ribosome Biogenesis, 99–126. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_7.
Повний текст джерелаBlanchet, Sandra, and Namit Ranjan. "Translation Phases in Eukaryotes." In Ribosome Biogenesis, 217–28. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_13.
Повний текст джерелаJüttner, Michael, and Sébastien Ferreira-Cerca. "A Comparative Perspective on Ribosome Biogenesis: Unity and Diversity Across the Tree of Life." In Ribosome Biogenesis, 3–22. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_1.
Повний текст джерелаBraun, Christina, Robert Knüppel, Jorge Perez-Fernandez, and Sébastien Ferreira-Cerca. "Non-radioactive In Vivo Labeling of RNA with 4-Thiouracil." In Ribosome Biogenesis, 199–213. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_12.
Повний текст джерелаPinz, Sophia, Eva Doskocil, and Wolfgang Seufert. "Thermofluor-Based Analysis of Protein Integrity and Ligand Interactions." In Ribosome Biogenesis, 247–57. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_15.
Повний текст джерелаSharma, Sunny, and Karl-Dieter Entian. "Chemical Modifications of Ribosomal RNA." In Ribosome Biogenesis, 149–66. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_9.
Повний текст джерелаKern, Michael, and Sébastien Ferreira-Cerca. "Differential Translation Activity Analysis Using Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) in Archaea." In Ribosome Biogenesis, 229–46. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_14.
Повний текст джерелаMerkl, Philipp E., Christopher Schächner, Michael Pilsl, Katrin Schwank, Catharina Schmid, Gernot Längst, Philipp Milkereit, Joachim Griesenbeck, and Herbert Tschochner. "Specialization of RNA Polymerase I in Comparison to Other Nuclear RNA Polymerases of Saccharomyces cerevisiae." In Ribosome Biogenesis, 63–70. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_4.
Повний текст джерелаBlanchet, Sandra, and Namit Ranjan. "In Vitro Assembly of a Fully Reconstituted Yeast Translation System for Studies of Initiation and Elongation Phases of Protein Synthesis." In Ribosome Biogenesis, 259–80. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_16.
Повний текст джерелаYang, Jun, Peter Watzinger, and Sunny Sharma. "Mapping of the Chemical Modifications of rRNAs." In Ribosome Biogenesis, 181–97. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_11.
Повний текст джерелаТези доповідей конференцій з теми "Ribosome biogensis"
Menoyo, Sandra, Antonio Gentilella, and George Thomas. "Abstract B05: Characterization of the pre-ribosomal complex, which mediates the p53 Impaired Ribosome Biogenesis Checkpoint (IRBC)." In Abstracts: AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; October 27-30, 2016; San Francisco, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.transcontrol16-b05.
Повний текст джерелаLessard, Frédéric, Véronique Bourdeau, Xavier Deschênes-Simard, Sebastian Igelmann, Marinieve Montero, and Gerardo Ferbeyre. "Abstract 2246: Senescence as a result of impaired ribosome biogenesis." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2246.
Повний текст джерелаDong, Zhixiong, Changjun Zhu, and Wei Jiang. "Abstract 835: hRrp15, a ribosome RNA processing protein, has profound function on nucleoli construction, ribosome biogenesis and cell proliferation." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-835.
Повний текст джерелаShakirov, Yevgeniy. "Ribosome biogenesis pathway underlies establishment of telomere length set point in Arabidopsis." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1375852.
Повний текст джерелаPearson, Richard B., Jennifer R. Devlin, Katherine M. Hannan, Nadine Hein, Megan J. Bywater, Gretchen Poortinga, Donald Cameron, et al. "Abstract 2735: Multi-point targeting of the synthetic lethal interactions between Myc, ribosome biogenesis and ribosome function cooperates to treat B-cell lymphoma." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2735.
Повний текст джерелаSun, Xiao-Xin, and Mushui Dai. "Abstract 1104: Perturbation of 60S ribosomal biogenesis results in ribosomal protein L5 and L11-dependent p53 activation." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1104.
Повний текст джерелаSheppard, Karen E., Natalie Brajanovski, Katherine M. Hannan, Jessica Ahearn, Jason Ellul, Denis Drygin, Sean O'Brien, Grant McArthur, Ross D. Hannan, and Richard B. Pearson. "Abstract 2718: Targeting ribosome biogenesis with CX5461 as a potential treatment for melanoma and ovarian cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2718.
Повний текст джерелаPenzo, Marianna, Lucia Casoli, Laura Sicuro, Alice Galibiati, Daniela Pollutri, Marzia Govoni, Claudio Ceccarelli, et al. "Abstract 5145: KDM2B expression regulates ribosome biogenesis and cancer cell growth in a p53-dependent manner." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5145.
Повний текст джерелаLessard, Frédéric, Véronique Bourdeau, Sebastian Igelmann, Xavier Deschênes-Simard, Marinieve Montero, and Gerardo Ferbeyre. "Abstract 1270: Ribosome biogenesis is reduced by oncogenic stress in normal cells and is sufficient to trigger cellular senescence." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1270.
Повний текст джерелаDevlin, Jennifer R., Richard J. Rebello, Katherine M. Hannan, Carleen Cullinane, Denis Drygin, Gail P. Risbridger, Luc Furic, Ross D. Hannan, and Richard B. Pearson. "Abstract 4809: Combination therapy targeting ribosome biogenesis and mRNA translation provides a novel and potent therapeutic approach to treat MYC-driven malignancy." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4809.
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